MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| BMS 182874 | BMS 182874 is an orallyactive, highly selective endothelin receptor ( ET A receptor) antagonist, with IC 50 value of 0.150 μM, K i of 0.055 μM. BMS 182874 reduces the arterial pressure of Deoxycorticosterone acetate (HY-B1472) induced hypertension model in rats, and can be used for cardiovascular disease research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 153042-42-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118497. |  |
| BMS-193885 | BMS-193885 is a selective neuropeptide Y1 receptor antagonist (Ki=3.3 nM) that competitively blocks the receptor to inhibit NPY-mediated appetite regulation signaling pathways, reduce food intake and inhibit weight gain. BMS-193885 has good blood-brain barrier penetration and is mainly used in the study of obesity and related metabolic diseases[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 186185-03-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120619. | |
| BMS-202 | BMS-202 is a potent and nonpeptidic PD-1/PD-L1 complex inhibitor with an IC 50 of 18 nM and a K D of 8 μM. BMS-202 binds to PD-L1 and blocks human PD-1/PD-L1 interaction. BMS-202 has antitumor activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1675203-84-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19745. | |
| BMS-214662 | BMS-214662 is a farnesyl transferase inhibitor. BMS-214662 can effectively block the localization and function of Ras protein in the cell membrane by inhibiting the pro-group modification of Ras protein, thereby exerting anti-tumor activity. BMS-214662 has an IC50 value of 1.3 nM for H-Ras and 8.4 nM for K-Ras. BMS-214662 can be used to study Ras-related tumor diseases[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 195987-41-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16111. | |
| BMS-265246 | BMS-265246 is a potent and selective cyclin-dependent kinase CDK1 and CDK2 inhibitor, with IC50 values of 6 and 9 nM, respectively. BMS-265246 inhibits CHI3L1 (chitinase 3-like-1) stimulation of ACE2 (angiotensin converting enzyme 2) and SPP (viral spike protein priming proteases). BMS-265246 can be used for ovarian cancer and COVID-19 research[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 582315-72-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15275. | |
| BMS-303141 | BMS-303141 is a potent, cell-permeable ATP-citrate lyase (ACL) inhibitor with an IC50 of 0.13 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 943962-47-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-16107. | |
| BMS-309403 | BMS-309403 is a potent, orally active and selective adipocyte fatty acid binding protein (also known as FABP4, aP2) inhibitor with Kis of <2, 250, and 350 nM for FABP4, FABP3, and FABP5, respectively. BMS-309403 interacts with the fatty-acid-binding pocket within the interior of the protein and competitively inhibits the binding of endogenous fatty acids. BMS-309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 300657-03-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-101903. | |
| BMS-345541 | BMS-345541 is a selective inhibitor of the catalytic subunits of IKK ( IKK-2 IC 50 =0.3 μM, IKK-1 IC 50 =4 μM). BMS-345541 binds at an allosteric site of IKK. Uses: Scientific research. Group: Signaling pathways. CAS No. 445430-58-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10519. | |
| BMS-345541 hydrochloride | BMS-345541 hydrochloride is a selective inhibitor of the catalytic subunits of IKK ( IKK-2 IC 50 =0.3 μM, IKK-1 IC 50 =4 μM). BMS-345541 binds at an allosteric site of IKK. Uses: Scientific research. Group: Signaling pathways. CAS No. 547757-23-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10518. | |
| BMS453 | BMS453 (BMS-189453), a synthetic retinoid, is a RAR? agonist and a RAR?/RAR? antagonist. BMS453 inhibits breast cell growth predominantly through the induction of active TGF?[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-189453. CAS No. 166977-43-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100608. | |
| BMS493 | BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 increases nuclear corepressor interaction with RARs. BMS493 also could prevent retinoic acid-induced differentiation[1][2]. BMS493 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 215030-90-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108529. | |
| BMS-5 | BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LIMKi 3. CAS No. 1338247-35-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18305. | |
| BMS-509744 | BMS-509744 is a potent, selective and ATP competitive Itk inhibitor with an IC50 of 19 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 439575-02-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11092. | |
| BMS-536924 | BMS-536924 is an orally active, competitive and selective insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IR) inhibitor with IC 50 s of 100 nM and 73 nM, respectively. BMS-536924 has anti-cancer activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 468740-43-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10262. | |
| BMS-561392 formate | BMS-561392 formate is the formate form of BMS-561392 (HY-19667). BMS-561392 is a TNF alpha-converting enzyme (TACE) inhibitor. BMS-561392 is also an ADAM17 blocker. BMS-561392 can be used for research of inflammatory bowel disease[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DPC 333 formate. CAS No. 2922280-85-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-19667A. | |
| BMS-564929 | BMS-564929 is an androgen receptor (AR) agonist, binds to androgen receptor (AR) with a Ki of 2.11±0.16 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 627530-84-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-12111. | |
| BMS-582949 hydrochloride | BMS-582949 hydrochloride is an orally active and highly selective p38α MAPK inhibitor, with an IC 50 of 13 nM. BMS-582949 hydrochloride displays a significantly improved pharmacokinetic profile and is effective in inflammatory disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 912806-16-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14305A. | |
| BMS-599626 Hydrochloride | BMS-599626 Hydrochloride (AC480 Hydrochloride) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC 50 s of 20 and 30 nM, respectively. BMS-599626 Hydrochloride displays ~8-fold less potent to HER4 (IC 50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. BMS-599626 Hydrochloride inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AC480 Hydrochloride. CAS No. 873837-23-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12010. | |
| BMS-754807 | BMS-754807 is a potent and reversible IGF-1R / IR inhibitor ( IC 50 =1.8 and 1.7 nM, respectively; K i =<2 nM for both). BMS-754807 also shows potent activities against Met, RON, TrkA, TrkB, AurA, and AurB with IC 50 values of 6, 44, 7, 4, 9, and 25 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1001350-96-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10200. | |
| BMS 777607 | BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met , Axl , Ron and Tyro3 with IC 50 s of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively, and 40-fold more selective for Met-related targets than Lck, VEGFR-2, and TrkA/B, with more than 500-fold greater selectivity versus all other receptor and non receptor kinases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS 817378. CAS No. 1025720-94-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12076. | |
| BMS-794833 | BMS-794833 is a VEGFR2 and Met inhibitor extracted from patent WO2009094417, compound example 1; has IC50s of 15 and 1.7 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1174046-72-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10497. | |
| BMS-813160 | BMS-813160 is a potent and selective CCR2/5 dual antagonist. BMS-813160 binds with CCR2 and CCR5 with IC 50 s of 6.2 and 3.6 nM, respectively. BMS-813160 can be used for the research of inflammation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1286279-29-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-109593. | |
| BMS-833923 | BMS-833923 (XL-139) is an orally biocompatible Smoothened (Smo) inhibitor with anti-tumor activity. It can inhibit the binding of BODIPY cyclopamine to SMO in a dose-dependent manner with an IC50 of 21 nM[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: XL-139. CAS No. 1059734-66-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13809. | |
| BMS-906024 | BMS-906024 is an orally active and selective ?-secretase (gamma secretase) inhibitor. BMS-906024 is a potent pan-Notch receptors inhibitor with IC50s of 1.6 nM, 0.7 nM, 3.4 nM, and 2.9 nM for Notch1, -2, -3, and -4 receptors, respectively. BMS-906024 demonstrates broad-spectrum antineoplastic activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1401066-79-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-15670. | |
| BMS-911543 | BMS-911543 is a selective JAK2 inhibitor, with IC 50 s of 1.1 nM, less selective at JAK1, JAK3 and TYK2 ( IC 50 , 75, 360, 66 nM, respectively). Uses: Scientific research. Group: Signaling pathways. CAS No. 1271022-90-2. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15270. | |
| BMS-978587 | BMS-978587 (IDO-IN-4) is an indoleamine 2,3-dioxygenase 1 ( IDO-1 ) inhibitor, extracted from patent WO2014150677A1, Compound example 1 enantiomer 1. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IDO-IN-4. CAS No. 1629125-65-0. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18769. | |
| BMS-986020 | BMS-986020 (AM152) is a high-affinity and selective lysophosphatidic acid receptor 1 (LPA1) antagonist[1]. BMS-986020 inhibits bile acid and phospholipid transporters with IC50s of 4.8 ?M, 6.2 ?M, and 7.5 ?M for BSEP, MRP4, and MDR3, respectively[2]. BMS-986020 has the potential for the treatment of idiopathic pulmonary fibrosis (IPF)[3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AM152. CAS No. 1257213-50-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100619. | |
| BMS-986020 sodium | BMS-986020 (AM152) sodium is a high-affinity lysophosphatidic acid receptor 1 (LPA1) antagonist[1]. BMS-986020 sodium inhibits bile acid and phospholipid transporters with IC50s of 4.8 ?M, 6.2 ?M, and 7.5 ?M for BSEP, MRP4, and MDR3, respectively[2]. BMS-986020 sodium has the potential for the treatment of idiopathic pulmonary fibrosis (IPF)[3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AM152 sodium. CAS No. 1380650-53-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100619A. | |
| BMS-986094 | BMS-986094 (INX-08189) is a potent inhibitor of hepatitis C virus (HCV) replication, with an EC 50 of 35 nM at 24 h in Huh-7 cells. BMS-986094 is a phosphoramidate proagent of 6-O-methyl-2-C-methyl guanosine. BMS-986094 can be used for the research of chronic HCV infection [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: INX-08189. CAS No. 1234490-83-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13337. | |
| BMS-986120 | BMS-986120 is a first-in-class oral and reversible protease-activated receptor 4 ( PAR4 ) antagonist, with IC 50 s of 9.5 nM and 2.1 nM in human and monkey blood, respectively. BMS-986120 has potent and selective antiplatelet effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1478712-37-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19837. | |
| BMS-986158 | BMS-986158 is a potent BET inhibitor with IC 50 s of 6.6 and 5?nM in NCI-H211 small cell lung cancer (SCLC) cells and MDA-MB231 triple negative breast cancer (TNBC) cells, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1800340-40-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-101567. | |
| BMS-986187 | BMS-986187 is an δ-opioid receptor -selective positive allosteric modulator (PAM) with an EC 50 of 0.03 μM and a pK B of 6.02 (~1 μM). BMS-986187 has no observable PAM activity at the μ-receptor (EC 50 =3 μM) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 684238-37-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120613. | |
| BMS-986189 | BMS-986189 is a macrocyclic peptide PD-1/PD-L1 interaction with an IC50 of 1.03 nM inhibitor. BMS-986189 can be used for cancer research, such as human lung carcinoma cells L2987[1][2]. Uses: Scientific research. Group: Peptides. CAS No. 1629665-96-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P10375. | |
| BMS-986224 | BMS-986224 is a potent, selective and orally active APJ receptor agonist (Kd = 0.3 nM). BMS-986224 exhibits similar receptor binding and signaling profile to (Pyr1) apelin-13. BMS-986224 has the potential for the research of heart failure[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2055200-88-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139485. | |
| BMS-986235 | BMS-986235 (LAR-1219) is a selective, orally active formyl peptide receptor 2 (FPR2) agonist, with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 has potential for the prevention of heart failure[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LAR-1219. CAS No. 2253947-47-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-131180. | |
| BMS-986278 | BMS-986278 is a potent and orally active lysophosphatidic acid receptor 1 (LPA1) antagonist, with K b s of 6.9 nM and 4.0 nM for human and mouse LPA1, respectively. BMS-986278 can be used for the research of pulmonary fibrotic diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2170126-74-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139853. | |
| BMS-986299 | BMS-986299 (compound 112) is a first-in-class NLRP3 inflammasome agonist with an EC 50 of 1.28 μM. (patent WO2018152396A1). Uses: Scientific research. Group: Signaling pathways. CAS No. 2242952-69-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139396. | |
| BMS-986365 | BMS-986365 (CC-94676) is an orally active and selective targeted androgen receptor ( AR ) PROTAC degrader, capable of inducing cereblon (CRBN) E3 ligase-dependent ubiquitination and degradation of the androgen receptor ( AR ), as well as various AR mutants. BMS-986365 shows significant in vivo potency, degrading AR , inhibiting AR signaling, and restricting tumor growth in animal models of advanced prostate cancer. (Blue: HY-W247437; Black: linker (HY-W126831); Pink: HY-168697) [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CC-94676. CAS No. 2446928-30-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158101. | |
| BMS-986397 | BMS-986397. Uses: Scientific research. Group: Signaling pathways. CAS No. 2564486-44-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-159646. | |
| BMS-P5 | BMS-P5 is a selective and orally active peptidylarginine deiminase 4 (PAD4) inhibitor with an IC50 of 98 nM. BMS-P5 shows selective for PAD4 over PAD1, PAD2, and PAD3. BMS-P5 blocks multiple myeloma (MM)-induced neutrophil extracellular trap (NET) formation and delays progression of MM in a syngeneic mouse model[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1549811-36-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137655. | |
| BMSpep-57 | BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 facilitates T cell function by in creasing IL-2 production in PBMCs[1]. Uses: Scientific research. Group: Peptides. CAS No. 1629655-80-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P3143. | |
| BMVC | BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor with an IC 50 of ~0.2 μM. BMVC inhibits Taq DNA polymerase with an IC 50 of ~2.5 μM. BMVC increases the melting temperature of G4 structure of telomere and accelerates telomere length shortening. Anticancer activities [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 627810-06-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135775. | |
| BMY 14802 | BMY 14802 is a sigma-1 receptor ( σ1R ) antagonist, as well as an agonist at serotonin (5-HT) 1A and adrenergic alpha-1 receptors. BMY 14802 inhibits abnormal involuntary movement (AIM) in rat Parkinson's disease (PD) model, with down-regulating the expression of AIM [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 105565-56-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153091. | |
| BMY-14802 hydrochloride | BMY-14802 hydrochloride (BMY-14802-1) is a selective and orally active sigma receptor antagonist with an IC 50 of 112 nM. BMY-14802 hydrochloride is also a 5-HT1A and adrenergic α1 receptors agonist. BMY-14802 hydrochloride has antipsychotic effects [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMY-14802-1; BMS 181100 hydrochloride. CAS No. 105565-55-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108509. | |
| BMY 7378 | BMY 7378 is a selective antagonist of α 1D -adrenoceptor (α 1D -AR). BMY 7378 binds to membranes expressing the cloned rat α 1D -AR with a >100-fold higher affinity ( K i =2 nM) than binding to either the cloned rat α 1A -AR (K i =800 nM) or the hamster α 1B -AR ( K i =600 nM). BMY 7378 is a 5-HT 1A receptor partial agonist [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 21102-95-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-100554. | |
| BN-104 | BN-104 (BNM-1192) is an effective selective brain membrane protein inhibitor with oral activity, and it's also a Menin inhibitor, it can block the Menin-MLL interaction and leads to the degradation of Menin protein. BN-104 is a weak hERG inhibitor, with an IC 50 greater than 100 μM. BN-104 has anti-tumor activity and can be used in cancer research, such as for acute myeloid leukemia [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BNM-1192; Menin-MLL inhibitor 27. CAS No. 2938995-50-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153714. | |
| BN82002 hydrochloride | BN82002 hydrochloride is a potent, selective and irreversible inhibitor of CDC25 phosphatase family. BN82002 hydrochloride inhibits CDC25A, CDC25B2, CDC25B3, CDC25C CDC25A, and 25C-cat with IC 50 values of 2.4, 3.9, 6.3, 5.4, and 4.6 μM, respectively. BN82002 hydrochloride displays ~20-fold greater selectivity over CD45 tyrosine phosphatase [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1049740-43-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112776A. | |
| BNN6 | BNN6 is a thermoresponsive nitric oxide (NO) donor that often works by binding to a carrier. BNN6 decomposes under the heat stimulation generated by photothermal action, releasing high concentrations of NO, which exerts anti-tumor activity by inducing tumor cell apoptosis and inhibiting their repair. BNN6 can be used to synthesize the multifunctional biosensor BNN6-BiTiS3-iRGD, which exerts a synergistic anti-cancer effect with photothermal therapy (PTT)[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 106476-75-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164117. | |
| BNS | BNS is a cell penetrant, potent and selective PHD2 (prolyl-hydroxylase 2) inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1417440-37-9. Pack Sizes: 5 mg. Product ID: HY-119351. | |
| BNT411 | BNT411 is a selective TLR7 agonist that can induce the release of IFNa both in vivo and in vitro. BNT411 has anticancer activity and can be used in cancer research, including non-small cell lung cancer, pancreatic cancer, and untreated extensive-stage small cell lung cancer (ES-SCLC) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2296821-50-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160715. | |
| BO-264 | BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis. BO-264 has broad-spectrum antitumor activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2408648-20-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135960. | |
| Bobcat339 | Bobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme , with IC 50 s of 33 μM and 73 μM for TET1 and TET2 , respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2280037-51-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-111558. | |
| Bobcat339 hydrochloride | Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme , with the IC 50 s of 33 μM and 73 μM for TET1 and TET2 , respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2436747-44-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-111558A. | |
| BOC-(1R,3S)-3-aminocyclopentane carboxylic acid | BOC-(1R,3S)-3-aminocyclopentane carboxylic acid ( (1S, 3S) -3-[ (tert-Butoxycarbonyl) amino]cyclopentanecarboxylic acid) is a synthetic intermediate useful for pharmaceutical synthesis. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (1S, 3S) -3-[ (tert-Butoxycarbonyl) amino]cyclopentanecarboxylic acid. CAS No. 161660-94-2. Pack Sizes: 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-W004812. | |
| Boc-6-aminohexanoic acid | Boc-6-aminohexanoic acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 6404-29-1. Pack Sizes: 5 g; 10 g; 25 g; 100 g. Product ID: HY-W007529. | |
| Boc-Ala-OMe | Boc-Ala-OMe is an alanine derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 28875-17-4. Pack Sizes: 25 g; 100 g; 500 g. Product ID: HY-W002173. | |
| (±)-Boc-α-phosphonoglycine trimethyl ester | (±)-Boc-α-phosphonoglycine trimethyl ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 89524-98-1. Pack Sizes: 1 g; 5 g. Product ID: HY-W008206. | |
| (Boc-aminooxy)acetic acid | (Boc-aminooxy)acetic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 42989-85-5. Pack Sizes: 10 mM * 1 mL; 5 g; 10 g. Product ID: HY-W019623. | |
| Boc-aminoxy-PEG4-acid | Boc-aminoxy-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2062663-68-5. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-140413. | |
| Boc-Arg(Pbf)-OH | Boc-Arg(Pbf)-OH is an arginine derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 200124-22-7. Pack Sizes: 25 g; 100 g. Product ID: HY-W008389. | |
| Boc-Asp(OMe)-OH | Boc-Asp(OMe)-OH is an aspartic acid derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 59768-74-0. Pack Sizes: 25 g; 100 g; 500 g. Product ID: HY-W007399. | |
| Boc-Asp(OtBu)-OH | Boc-Asp(OtBu)-OH is an aspartic acid derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 1676-90-0. Pack Sizes: 25 g; 100 g. Product ID: HY-W002326. | |
| Boc-β-Ala-OH | Boc-β-Ala-OH is an alanine derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 3303-84-2. Pack Sizes: 500 g. Product ID: HY-W015231. | |
| Boc-β-HoAsp(OBzl)-OH | Boc-β-HoAsp(OBzl)-OH is a glutamic acid derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 254101-10-5. Pack Sizes: 100 mg; 500 mg; 1 g. Product ID: HY-W013210. | |
| Boc-Cys(Npys)-OH | Boc-Cys(Npys)-OH is a cysteine derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 76880-29-0. Pack Sizes: 100 mg; 250 mg; 1 g. Product ID: HY-W141779. | |
| Boc-Cystamine | Boc-Cystamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 485800-26-8. Pack Sizes: 100 mg; 250 mg. Product ID: HY-140098. | |
| Boc-D-2,3-diaminopropionic acid | Boc-D-2,3-diaminopropionic acid (N-t-Boc-amino-D-alanine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize a potent NMDA receptor glycine site agonist with GluN2 subunit-specific activity [1]. Uses: Scientific research. Group: Peptides. Alternative Names: N-t-Boc-amino-D-alanine; Boc-D-Dap-OH. CAS No. 76387-70-7. Pack Sizes: 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-W014692. | |
| Boc-D-alaninol | Boc-D-alaninol is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 106391-86-0. Pack Sizes: 10 mM * 1 mL; 5 g; 10 g. Product ID: HY-W008185. | |
| Boc-D-Asp-OBzl | Boc-D-Asp-OBzl is an aspartic acid derivative [1]. Uses: Scientific research. Group: Peptides. Alternative Names: (R)-2-tert-Butoxycarbonylaminosuccinic acid 1-benzyl ester. CAS No. 92828-64-3. Pack Sizes: 5 g; 10 g; 25 g; 100 g. Product ID: HY-Y0029. | |
| Boc-D-Pyr-Oet | Boc-D-Pyr-Oet (N-Boc-D-pyroglutamic acid ethyl ester) is used as a biochemical assay reagent [1]. Uses: Scientific research. Group: Peptides. Alternative Names: N-Boc-D-pyroglutamic acid ethyl ester. CAS No. 144978-35-8. Pack Sizes: 25 g; 50 g; 100 g. Product ID: HY-W003605. | |
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