MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| (-)-Bornyl acetate | (-)-Bornyl acetate (L-(-)-Bornyl acetate), isolated from hyssop oil, is a less active enantiomer of (+)-Bornyl acetate. (-)-Bornyl acetate possesses antifungal activity [1]. Uses: Scientific research. Group: Natural products. Alternative Names: L-(-)-Bornyl acetate. CAS No. 5655-61-8. Pack Sizes: 10 mM * 1 mL; 5 g. Product ID: HY-N0756A. |  |
| (+)-Bornyl acetate | (+)-Bornyl acetate is found in pichtae essential oil (Siberian fir needle oil). (+)-Bornyl acetate has a stronger inhibitory effect on root growth of Arabidopsis seedlings [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 20347-65-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-B1918. | |
| Bornyl acetate | Bornyl acetate is a potent odorant, exhibiting one of the highest flavor dilution factor (FD factor). Bornyl acetate possesses anti-cancer activity [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 76-49-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-N0756. | |
| Borocaptate sodium | Borocaptate sodium is a boron-containing compound that can be used as a therapeutic agent in boron neutron capture therapy (BNCT), exhibiting anticancer activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BSH. CAS No. 144885-51-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142041. | |
| Borrelidin | Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor which is a nitrile-containing macrolide antibiotic isolated from Streptomyces rochei[1]. Borrelidin is an inhibitor of Cdc28/Cln2 of the budding yeast, with an IC50 of 24 ?M[2]. Borrelidin is a potent angiogenesis inhibitor, with an IC50 of 0.8 nM. Borrelidin induces apoptosis in the tube-forming cells[3]. Borrelidin has strong antimalarial activities, with IC50s of 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum, respectively[4]. Uses: Scientific research. Group: Natural products. Alternative Names: Treponemycin. CAS No. 7184-60-3. Pack Sizes: 500 ?g; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N6742. | |
| Bortezomib | Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome ( K i =0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PS-341; LDP-341; NSC 681239. CAS No. 179324-69-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10227. | |
| Borussertib | Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1800070-77-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-122913. | |
| BOS-318 | BOS-318 is a potent, slowly dissociating, highly selective, and cell-permeable furin inhibitor with IC50 value of 1.9 nM. BOS-318 protects ENaC from subsequent activation by neutrophil elastase. BOS-318 can be used for the rsearch for CF lung disease[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2387633-15-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147140. | |
| Boscalid | Boscalid is an anti-fungal agent. Boscalid is a succinate dehydrogenase (SDH) inhibitor [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 188425-85-6. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-119976. | |
| Bosentan | Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ET A and ET B receptors with K i of 4.7 nM and 95 nM in human SMC, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 147536-97-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-A0013. | |
| Bosentan hydrate | Bosentan hydrate is a competitive and dual antagonist of endothelin-1 (ET) for the ET A and ET B receptors with K i of 4.7 nM and 95 nM in human SMC, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 157212-55-0. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-A0013A. | |
| Boserolimab | Boserolimab (MK-5890) is a humanized agonist monoclonal antibody that binds to CD27 to provide a costimulatory signal that enhances T-cell - mediated responses [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MK-5890. CAS No. 2444297-08-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990018. | |
| Bosutinib | Bosutinib is an orally active Src/Abl tyrosine kinase inhibitor with IC 50 of 1.2 nM and 1 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SKI-606. CAS No. 380843-75-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10158. | |
| Bosutinib hydrate | Bosutinib hydrate is an oraly activel Src/Abl tyrosine kinase inhibito with IC 50 of 1.2 nM and 1 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SKI-606 hydrate. CAS No. 918639-08-4. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10158A. | |
| Botensilimab | Botensilimab (AGEN 1181), a human anti- cytotoxic T-lymphocyte antigen 4 (CTLA-4) monoclonal antibody, is an innate and adaptive immune activator. Botensilimab can be used for the research of cancer [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: AGEN 1181. CAS No. 2408310-37-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99484. | |
| Bourgeonal | Bourgeonal is a potent agonist of hOR17-4 and acts as a strong chemoattractant in sperm behavioral assays [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 18127-01-0. Pack Sizes: 500 mg. Product ID: HY-31962. | |
| Bovin beta-1,4-galactosyltransferase 1 (Y289L) | Bovin beta-1,4-galactosyltransferase 1 (Y289L) (Bovin B4GALT1 (Y289L)) is a mutated form of bovine-derived galactosyltransferase with a mutation at the Y289L genetic site. Bovin beta-1,4-galactosyltransferase 1 can label O-GlcNAcylated proteins with an N-azidoacetylgalactosamine (GalNAz) group. This labeling method allows for the specific, unbiased, and global labeling of O-GlcNAcylated proteins. After labeling, the appended azide group can react with a wide variety of alkyne-modified chemical probes, facilitating multiple downstream analyses[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Bovin B4GALT1 (Y289L). Pack Sizes: 100 ?g; 1 mg. Product ID: HY-E70289. | |
| Bovine Serum Albumin | Bovine Serum Albumin (BSA) is a 583-residue protein consisting of three homologous all-α domains, organized in a heart-shaped structure. BSA is a globular protein that is used in numerous biochemical applications. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Albumin bovine serum; BSA. CAS No. 9048-46-8. Pack Sizes: 500 mg; 1 g; 5 g; 10 g. Product ID: HY-D0842. | |
| Bovine Serum Albumin (Low Endotoxin,Fatty acid free) | Bovine Serum Albumin (Low Endotoxin,Fatty acid free) (BSA) is a 583 amino acid globular protein and oligonucleotide binding protein composed of three homologous full ? domains. Bovine Serum Albumin (Low Endotoxin,Fatty acid free) (BSA) blocks the overall binding of oligonucleotides to cells. Bovine Serum Albumin (Low Endotoxin,Fatty acid free) (BSA) regulates the development of hamster embryos and induces arthritis[1][2][3][4]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Albumin bovine serum (Low Endotoxin,Fatty acid free); BSA (Low Endotoxin,Fatty acid free). CAS No. 9048-46-8. Pack Sizes: 1 g; 5 g. Product ID: HY-D0842A. | |
| Box5 | Box5 is a potent Wnt5a antagonist. Box5 inhibits Wnt5a signaling and inhibits Wnt5a-mediated Ca 2+ release. Box5 inhibits cell migration. Box5 has the potential for the research of melanoma [1]. Uses: Scientific research. Group: Peptides. CAS No. 1206604-29-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-123071. | |
| BP-1-102 | BP-1-102 is an orally available, small-molecule inhibitor of transcription factor Stat3, with an IC50 of 6.8 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 1334493-07-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-100493. | |
| BPC 157 | BPC 157 is the 15-amino acide fragment of gastric peptide BPC. BPC 157 exhibits wound healing promoting and neuroprotective activity. BPC 157 maintains the integrity of the gastrointestinal mucosa without significant toxicity. BPC 157 acetate counteracts NSAIDs/insulin overdose/copper-induced toxicity. BPC 157 ameliorates specific (over)stimulated/damaged neurotransmitter systems-induced behavioral disorders through serotonergic and dopaminergic systems [1] [2] [3]. Uses: Scientific research. Group: Peptides. CAS No. 137525-51-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105174. | |
| BPDBA | BPDBA is a selective and noncompetitive betaine/GABA transporter ( BGT-1 ) inhibitor with IC 50 s of 20 μM and 35 μM against human BGT-1 and mouse GAT2, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 312281-74-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119591. | |
| BPHA | BPHA is a potent and orally active MMP-2 , MMP-9 and MMP-14 inhibitor with IC 50 s of 12 nM, 16 nM and 17 nM, respectively. BPHA does not inhibit MMP-1, -3, and -7 (the IC 50 s are 974, >1000, and 795 nM, respectively). BPHA has antiangiogenic and antitumor effects [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 193807-60-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114785. | |
| BPI-9016M | BPI-9016M is a potent, orally active, and selective dual c-Met and AXL tyrosine kinases inhibitor. BPI-9016M suppresses tumor cell growth, migration and invasion of lung adenocarcinoma [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1528546-94-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114356. | |
| bPiDDB | bPiDDB is a potent nAChR antagonist. bPiDDB potently ( IC 50 =2 nM) inhibits nicotine-evoked striatal dopamine (DA) release through an interaction with α6β2-containing nAChRs [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 525596-66-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107674. | |
| BPK-25 | BPK-25, an active acrylamide, promotes degradation of nucleosome remodeling and deacetylation (NuRD) complex proteins by a post-translational mechanism involving covalent protein engagement. BPK-25 inhibits TMEM173 activation by the cyclic dinucleotide ligand cGAMP[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2305052-86-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141550. | |
| BPO-27 racemate | BPO-27 racemate is a potent CFTR inhibitor with an IC 50 of 8 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1314873-02-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-19778A. | |
| BPR1R024 | BPR1R024 is an orally active and selective colony-stimulating factor-1 receptor (CSF1R) inhibitor. BPR1R024 has potent CSF1R inhibition activity with an IC 50 value of 0.53 nM. BPR1R024 can be used for the research of immuno-oncology [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2503015-75-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-132935. | |
| BPTES | BPTES is an allosteric and selective glutaminase inhibitor with an IC50 of 0.16 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 314045-39-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-12683. | |
| BPTF-IN-BZ1 | BPTF-IN-BZ1, a BPTF inhibitor, possesses a high potency (Kd = 6.3 nM). Uses: Scientific research. Group: Signaling pathways. CAS No. 2766623-38-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132889. | |
| BpV(HOpic) | BpV(HOpic) is a potent and selective inhibitor of PTEN with an IC50 of 14 nM. Nanocarrier-BpV(HOpic) has neuroprotective activity[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Bisperoxovanadium. CAS No. 722494-26-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-128693. | |
| BpV(phen) trihydrate | BpV(phen) trihydrate, a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP-? and PTP-1B, respectively. BpV(phen) trihydrate inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) trihydrate strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFN?). BpV(phen) trihydrate can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity[1][2][3][4][5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Bisperoxovanadium(phen) trihydrate. CAS No. 171202-16-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122818. | |
| BQ-123 | BQ-123 is a potent and selective endothelin A (ETA) receptor antagonist with an IC 50 of 7.3 nM and a K i of 25 nM. BQ-123 inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells and lowers blood pressure in different rat models of hypertension [1] [2] [3]. Uses: Scientific research. Group: Peptides. CAS No. 136553-81-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-12378. | |
| BQ-788 | BQ-788 is a potent, selective ETB receptor antagonist with IC 50 of 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells, poorly inhibiting the binding to ETA receptors in human neuroblastoma cell line SK-N-MC cells with IC 50 of 1300 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 173326-37-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-15894A. | |
| BQ-788 sodium salt | BQ-788 sodium salt is a potent and selective ETB receptor antagonist, inhibiting ET-1 binding to ETB receptors with an IC 50 of 1.2 nM in human Girrardi heart cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 156161-89-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-15894. | |
| BQCA | BQCA a highly selective allosteric modulator of the M1 mAChR. Uses: Scientific research. Group: Signaling pathways. CAS No. 338747-41-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101858. | |
| Braco-19 | Braco-19 is a potent telomerase/telomere inhibitor, preventing the capping and catalytic action of telomerase. Braco-19 acts as G-quadruplex (GQ) binding ligand, stabilizing G-quadruplexes formation at the 3V telomeric DNA overhang and produce rapid senescence or selective cell death. Braco-19 is also a HAdV virus replication inhibitor[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 351351-75-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15523. | |
| Braco-19 trihydrochloride | Braco-19 trihydrochloride is a potent telomerase/telomere inhibitor, preventing the capping and catalytic action of telomerase. Braco-19 acts as G-quadruplex (GQ) binding ligand, stabilizing G-quadruplexes formation at the 3V telomeric DNA overhang and produce rapid senescence or selective cell death. Braco-19 is also a HAdV virus replication inhibitor[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1177798-88-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15523A. | |
| Bractoppin | Bractoppin is a potent and selective agent-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem(t) BRCT domain (binding IC50: 74 nM). Bractoppin diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51. Bractoppin preferentially inhibits BRCA1 tBRCT-dependent steps in the DNA damage response[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2290527-07-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126020. | |
| Bradanicline | Bradanicline is a highly selective α7 nicotinic acetylcholine receptor (nAChR) agonist (humanα7 nAChR: EC 50 =17 nM; K i = 1.4 nM). Bradanicline is used for the research of cognitive disorders [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TC-5619. CAS No. 639489-84-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18060. | |
| Bradykinin | Bradykinin is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Peptides. CAS No. 58-82-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0206. | |
| Bradykinin (1-5) | Bradykinin (1-5) is a major stable metabolite of Bradykinin, formed by the proteolytic action of angiotensin-converting enzyme (ACE). Uses: Scientific research. Group: Peptides. CAS No. 23815-89-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P1488. | |
| Bradykinin (2-9) | Bradykinin (2-9) is an amino-truncated Bradykinin peptide. Bradykinin (2-9) is a metabolite of Bradykinin, cleaved by Aminopeptidase P. Uses: Scientific research. Group: Peptides. Alternative Names: Des-Arg1-bradykinin. CAS No. 16875-11-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1490. | |
| BRAF inhibitor | BRAF inhibitor is a B-Raf inhibitor with anti-tumor activity extracted from patent WO/2011103196 A1, Compound P-0850. Uses: Scientific research. Group: Signaling pathways. CAS No. 918505-61-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-10247. | |
| Braftide | Braftide is an allosteric inhibitor for BRAF kinase by targeting the dimer interface of BRAF kinase and inhibiting the formation of BRAF dimers. Braftide inhibits wild-type BRAF and oncogenic BRAF G469A with IC 50 of 364 nM and 172 nM, respectively. Braftide inhibits MAPK signaling pathway, inhibits proliferation of KRAS mutant tumor cells ( EC 50 is 7.1 and 6.6 μM, for HCT116 and HCT-15), in combination of TAT sequence [1]. Uses: Scientific research. Group: Peptides. CAS No. 2411851-64-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P10436. | |
| Brain natriuretic peptide | Brain natriuretic peptide inhibits angiotensin II-induced blood pressure. Brain natriuretic peptide can be used in the control of blood pressure [1]. Uses: Scientific research. Group: Peptides. Alternative Names: BNP (1-32), human. CAS No. 114471-18-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-129067. | |
| Brain Natriuretic Peptide-45, mouse | Brain Natriuretic Peptide-45, mouse (BNP-45, mouse) is a circulating form of mouse brain natriuretic peptide isolated from mouse heart with potent hypotensive and natriuretic potency [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: BNP-45, mouse. CAS No. 1816939-52-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2469. | |
| Branaplam | Branaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC 50 of 20 nM for SMN. Branaplam inhibits human-ether-a-go-go-related gene (hERG) with an IC 50 of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LMI070; NVS-SM1. CAS No. 1562338-42-4. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19620. | |
| Branaplam hydrochloride | Branaplam (LMI070; NVS-SM1) hydrochloride is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC 50 of 20 nM for SMN. Branaplam hydrochloride inhibits human-ether-a-go-go-related gene (hERG) with an IC 50 of 6.3 μM. Branaplam hydrochloride elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LMI070 hydrochloride; NVS-SM1 hydrochloride. CAS No. 1562338-39-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19620A. | |
| Branebrutinib | Branebrutinib (BMS-986195) is a highly potent, selective covalent, irreversible inhibitor of Brutons tyrosine kinase (BTK) , with an IC 50 of 0.1 nM [1] [2]. Branebrutinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-986195. CAS No. 1912445-55-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112161. | |
| Brassicasterol | Brassicasterol is a metabolite of Ergosterol and has cardiovascular protective effects. Brassicasterol exerts anticancer effects in prostate cancer through dual targeting of AKT and androgen receptor signaling pathways. Brassicasterol inhibits HSV-1 ( IC 50 =1.2 μM) and Mycobacterium tuberculosis. Brassicasterol also inhibits sterol δ 24-reductase , slowing the progression of atherosclerosis. Brassicasterol is also a cerebrospinal fluid biomarker for Alzheimer's disease [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Natural products. CAS No. 474-67-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-113289. | |
| Brassinazole | Brassinazole is a selective triazole-type brassinosteroid (BR) biosynthesis inhibitor. Brassinazole is used for regulating plant growth and development [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 280129-83-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-121161A. | |
| Brassinin | Brassinin is the metabolism of a phytoalexin from Beassica pekinensis (Lour. ) Rupr. [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Brassinine. CAS No. 105748-59-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-111334. | |
| Brassinolide | Brassinolide is a predominant plant growth modulator that regulate plant cell elongation. Uses: Scientific research. Group: Natural products. Alternative Names: Brassin lactone. CAS No. 72962-43-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0273. | |
| Brazikumab | Brazikumab (AMG 139) is a human IgG2 monoclonal antibody, selectively binds the p19 subunit of IL-23 , with a K D of 0.138 nM for human IL-23. Brazikumab can be used for the research of Crohn's disease [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: AMG 139; MEDI2070. CAS No. 1610353-18-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99485. | |
| Brazilin | Brazilin is a red dye precursor obtained from the heartwood of several species of tropical hardwoods. Brazilin inhibits the cells proliferation, promotes apoptosis , and induces autophagy through the AMPK/mTOR pathway. Brazilin shows chondroprotective and anti-inflammatory activities [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 474-07-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0072. | |
| BrBzGCp2 | BrBzGCp2 is a Glyoxalase 1 (GLO1) inhibitor, with a GC50 of 4.23 ?M in HL-60 cells. BrBzGCp2 possesses antitumor and neuroprotective activity[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: S-p-Bromobenzylglutathione cyclopentyl diester. CAS No. 166038-00-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136684. | |
| BRD0705 | BRD0705 is a potent, paralog selective and orally active GSK3? inhibitor with an IC50 of 66 nM and a Kd of 4.8 ?M. BRD0705 displays increased selectivity for GSK3? (8-fold) versus GSK3? (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML) research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2056261-41-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116830. | |
| BRD3308 | BRD3308 is a highly selective HDAC3 inhibitor with an IC50 of 54 nM. BRD3308 is 23-fold selectivity for HDAC3 over HDAC1 (IC50 of 1.26 ?M) or HDAC2 (IC50 of 1.34 ?M). BRD3308 suppresses pancreatic ?-cell apoptosis induced by inflammatory cytokines or glucolipotoxic stress, and increases functional insulin release. BRD3308 activates HIV-1 transcription and disrupts HIV-1 latency[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1550053-02-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19618. | |
| BRD4 degrader-3 | BRD4 degrader-3 is a potent bromodomain BRD4 degrader extracted from patent WO2020055976A1, example 1a, has IC 50 s of 15.5 and 12.3 nM for BRD4-BD1 and BRD4-BD2, respectively [1]. PROTAC BRD4 Degrader-7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2413382-30-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136857. | |
| BRD4-IN-4 | BRD4-IN-4 (Compound 1) is a BRD4 inhibitor ( IC 50 =6.83 μM). BRD4-IN-4 selectively inhibits MV4-11 cell line proliferation and arrests cell at G1 phase. BRD4-IN-4 can be used for research of MLL leukemia [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 304685-40-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-153751. | |
| BRD4 ligand 6 TFA | BRD4 ligand 6 TFA is the TFA salt form of BRD4 ligand 6 (HY-161651). BRD4 ligand 6 TFA is a BRD4 ligand and can be used for synthesis of BRD4 PROTACs, such as PROTAC BRD4 Degrader-26 (HY-161650) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2763548-61-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161651A. | |
| BRD5529 | BRD5529 is an effective dose-dependent CARD9-TRIM62 protein-protein interaction (PPI) inhibitor with an IC50 value of 8.6 ?M. BRD5529 has potency and complete inhibition of CARD9 ubiquitinylation in vitro, also has favorable solubility. BRD5529 can be used for the research of inflammatory bowel disease (IBD) such as Crohns disease (CD) and ulcerative colitis (UC)[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1358488-78-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115497. | |
| BRD-6929 | BRD-6929 is a potent, selective brain-penetrant inhibitor of class I histone deacetylase HDAC1 and HDAC2 inhibitor with IC50 of 1 nM and 8 nM, respectively. BRD-6929 shows high-affinity to HDAC1 and HDAC2 with Ki of 0.2 and 1.5 nM, respectively. BRD-6929 can be used for mood-related behavioral model research[3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 849234-64-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100719. | |
| BRD7552 | BRD7552, a potent PDX1 transcription factor inducer, upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. BRD7552 increases insulin expression. PDX1 is a key transcription factor involved in pancreas development and ? cell function[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1137359-47-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-19694. | |
| BRD-K98645985 | BRD-K98645985 is a BAF (mammalian SWI/SNF) transcriptional repression inhibitor with an EC50 of ~2.37 ?M. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, without T cell activation or toxicity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1357647-78-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-114268. | |
| Brecanavir | Brecanavir (GW640385) is a novel, potent HIV protease inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GW640385. CAS No. 313682-08-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-121240. | |
| Brefeldin A | Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus [1] [2]. Brefeldin A is also an autophagy and mitophagy inhibitor [3]. Brefeldin A is a CRISPR/Cas9 activator [5]. Brefeldin A inhibits HSV-1 and has anti-cancer activity [5]. Uses: Scientific research. Group: Natural products. Alternative Names: BFA; Cyanein; Decumbin. CAS No. 20350-15-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16592. | |
| Bremelanotide Acetate | Bremelanotide Acetate (PT-141 Acetate), a synthetic peptide analogue of α-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R for the treatment of sexual dysfunction [1]. Uses: Scientific research. Group: Peptides. Alternative Names: PT-141 Acetate. CAS No. 1607799-13-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18678A. | |
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