MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Catestatin (human) | Catestatin human, a catecholamine release-inhibitory peptide, is a pleiotropic peptide involved in cardiovascular protection with its antihypertensive and angiogenic effects. Catestatin human can be used in the study of inflammatory diseases [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Human chromogranin A 352 - 372. CAS No. 197151-46-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3395. |  |
| Catharanthine | Catharanthine ((+)-3,4-Didehydrocoronaridine), a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca 2+ channel (VOCC). Catharanthine has IC 50 s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine lowers blood pressure (BP), heart rate (HR). Catharanthine has anti-cancer activity [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (+)-3,4-Didehydrocoronaridine. CAS No. 2468-21-5. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-N0252. | |
| Catharanthine Tartrate | Catharanthine ((+)-3,4-Didehydrocoronaridine) Tartrate, a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca 2+ channel (VOCC). Catharanthine Tartrate has IC 50 s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine Tartrate lowers blood pressure (BP), heart rate (HR). Catharanthine Tartrate has anti-cancer activity [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (+)-3,4-Didehydrocoronaridine Tartrate. CAS No. 4168-17-6. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-N0252A. | |
| Cathepsin B, Bovine spleen | Cathepsin B, Bovine spleen is a cysteine protease and is involved in multiple kinds of programmed cell death (including apoptosis, pyroptosis, ferroptosis, necroptosis, and autophagic cell death) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9047-22-7. Pack Sizes: 100 μg. Product ID: HY-P2780. | |
| Cathepsin G, human neutrophils | Cathepsin G, human neutrophils (CTSH; ACC4) a serine protease found in polymorphonuclear neutrophils (PMNs), functions in inflammation [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CTSH; ACC4; ACC5. CAS No. 56645-49-9. Pack Sizes: 100 μg. Product ID: HY-E70227. | |
| Cathepsin G Inhibitor I | Cathepsin G Inhibitor I (compound 7) is an effective, selective, reversible, competitive, non-peptide cathepsin G inhibitor (IC50=53 nM; Ki=63 nM)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 429676-93-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103351. | |
| Cathepsin L | Cathepsin L is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Signaling pathways. CAS No. 60616-82-2. Pack Sizes: 25 μg. Product ID: HY-P2923. | |
| Cathepsin S, human | Cathepsin S, human, is a potent cysteine protease that promotes the degradation of damaged or harmful proteins in the endolysosomal pathway. Cathepsin S, human, is involved in multiple pathological processes, including arthritis, cancer, and cardiovascular disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CTSS. CAS No. 71965-46-3. Pack Sizes: 50 μg. Product ID: HY-E70226. | |
| Catumaxomab | Catumaxomab, a trifunctional IgG2 antibody, is composed of mouse and rat heavy and light chains and binds to human EpCAM and human CD 3 receptors. The Fc region of Catumaxomab region has binding affinity for FcγR1 (CD 64), FcγRIIA (CD 32a), and FcγRIII (CD 16). Catumaxomab can be used for anti-tumor research, especially epithelial cancers [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 509077-98-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9954. | |
| CAU | CAU (FCpApU) is an anticodon of the initiator tRNA (tRNAfMet). CAU is the major determinant for aminoacylation of tRNAfMet by MetRS [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CpApU. CAS No. 3022-32-0. Pack Sizes: 1 mg. Product ID: HY-159850. | |
| Cavosonstat | Cavosonstat (N91115) is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor. Cavosonstat is a CFTR stabilizer, and can be used for cystic fibrosis research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N91115. CAS No. 1371587-51-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109027. | |
| CAY 10462 dihydrochloride | CAY 10434 dihydrochloride is a potent CYP4A hydroxylase inhibitor. CAY 10434 dihydrochloride improves contractile response to angiotensin II with the maximal contractile response (E max ) 6764 mg [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 502656-68-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-120648A. | |
| CAY10464 | CAY10464 (AHR antagonist 7; compound 4j) is a selective and high-affinity aryl hydrocarbon receptor (AhR) antagonist with a K i of 1.4 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AHR antagonist 7. CAS No. 688348-37-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112628. | |
| CAY10499 | CAY10499 (MAGL-IN-5) is a non-selective lipase inhibitor with IC50 values of 144 nM and 14 nM for monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), respectively. Additionally, CAY10499 exhibits anti-inflammatory and antiviral activities[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MAGL-IN-5. CAS No. 359714-55-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119283. | |
| CAY10566 | CAY10566 is a potent, orally bioavailable and selective stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50s of 4.5 and 26 nM in mouse and human enzymatic assays, respectively.CAY10566 also shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50=7.9 nM or 6.8 nM)[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 944808-88-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-15823. | |
| CAY10603 | CAY10603 (BML-281) is a potent and selective HDAC6 inhibitor, with an IC50 of 2 pM; CAY10603 (BML-281) also inhibits HDAC1, HDAC2, HDAC3, HDAC8, HDAC10, with IC50s of 271, 252, 0.42, 6851, 90.7 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BML-281. CAS No. 1045792-66-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18613. | |
| CAY10650 | CAY10650 is a highly potent cytosolic phospholipase A2? (cPLA2?) inhibitor with an IC50 value of 12 nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1233706-88-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10801. | |
| Caylin-2 | Caylin-2, a Nutlin-3 analog, is a MDM2 inhibitor. Caylin-2 can bind to Bcl-X L [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1392830-09-9. Pack Sizes: 1 mg. Product ID: HY-117585. | |
| CB1 agonist 1 | CB1 agonist 1 (compound 22) is an agonist of CB1. CB1 agonist 1 shows affinity to CB1 receptor with an pIC 50 value of 5.7. CB1 agonist 1 can be used for the research of brain disorders [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 851212-80-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148137. | |
| CB1 antagonist 4 | CB1 antagonist 4 (compound 8) is a peripheral selective cannabinoid receptor type 1 (CB1) receptor antagonist. CB1 antagonist 4 shows limited penetrance to the brain in order to minimize or prevent CNS adverse reactions, and preserves potential antiobesity effects. CB1 antagonist 4 reduces propensity for psychiatric side effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1253641-65-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112340. | |
| CB1R antagonist 1 | CB1R Allosteric modulator 5, a selective cannabinoid-1 receptor (CB1R) inverse agonist with an IC 50 value of 4.2 μM and EC 50 value of ?10 μM. CB1R Allosteric modulator 5 can be used for the research of metabolic and obesity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 334668-69-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-150067. | |
| CB-25 | CB-25 is a ligand of CB1 cannabinoid receptors , acting as a partial agonist. CB-25 enhances Forskolin (HY-15371)-induced cAMP formation in cancer cells but not hCB1-CHO cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 869376-63-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121541. | |
| CB2 receptor agonist 10 | CB2 receptor agonist 10 is a CB2 receptor agonist with a K i of 3.7 nM for hCB2 , a K i of 110 nM for hCB1 , and an EC 50 of 0.52 nM for hCB2 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1046140-32-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-113591. | |
| CB2 receptor agonist 2 | CB2 receptor agonist 2 is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor with a K i of 8.5 nM. CB2 receptor agonist 2 has high affinity and selectivity for CB2 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1314230-75-5. Pack Sizes: 5 mg. Product ID: HY-132217. | |
| CB-5083 | CB-5083 is a first-in-class, potent, selective, and orally bioavailable inhibitor of the p97 AAA ATPase / VCP. CB-5083 selectively inhibits p97 through its D2 site with the IC 50 of 11 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1542705-92-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12861. | |
| CB-5339 | CB-5339 is an oral activity potent p97 inhibitor with an IC 50 <30 nM. CB-5339 can be used for leukemia research [1]. CB-5339 extracted from WO2015109285A1 compound FF07. Uses: Scientific research. Group: Signaling pathways. CAS No. 1863952-15-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128724. | |
| CB-6644 | CB-6644 is a selective inhibitor of RUVBL1/2 complex with anti-cancer activity. CB-6644 blocks the ATPase activity of RUVBL1/2 with an IC50 of 15 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2316817-88-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-114429. | |
| CBL0137 | CBL0137, a curaxin compound, is a histone chaperone facilitates chromatin transcription (FACT) inhibitor. CBL0137 downregulates NF- B and activates p53. CBL0137 restores both histone H3 acetylation and trimethylation. CBL0137 is an anticancer agent. CBL0137 induces cancer cell apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Curaxin 137; CBL-C137. CAS No. 1197996-80-7. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18935. | |
| CBL0137 hydrochloride | CBL0137 hydrochloride is an inhibitor of the histone chaperone, FACT. CBL0137 hydrochloride can also activate p53 and inhibits NF-κB with EC 50 s of 0.37 and 0.47 μM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Curaxin-137 hydrochloride; CBL-C137 hydrochloride. CAS No. 1197397-89-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18935A. | |
| Cbl-b-IN-1 | Cbl-b-IN-1 (Example 519) is an inhibitor of Cbl-b, with an IC50 of less than 100 nM. Cbl-b-IN-1 can promote the secretion of cytokines such as IL-2, IFN-?, and TNF-?, facilitate T cell activation, and enhance the TCR signaling pathway. Cbl-b-IN-1 can be used in research on immunomodulation[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2368841-84-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136339. | |
| CBPD-409 | CBPD-409 is an orally active PROTAC degrader for CBP/p300, with DC50 of 0.2-0.4 nM. CBPD-409 exhibits antiproliferative effects in AR+ prostate cancer cell lines VCaP, LNCaP and 22Rv1, with IC50s of 1.2-2.0 nM. CBPD-409 exhibits antitumor efficacy (Red: CBP inhibitor GNE049 (HY-108435); Blue: CRBN/cullin 4A Thalidomide (HY-14658); Black: Linker)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3037549-86-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-158113. | |
| CBP/p300-IN-19 hydrochloride | CBP/p300-IN-19 hydrochloride is a potent and selective p300/CBP HAT inhibitor with IC 50 s of 1.4, 2.2, >100, >100 μM for p300-HAT, CBP-HAT, PCAF, Myst3, respectively. CBP/p300-IN-19 hydrochloride shows antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2592638-14-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146277A. | |
| CBP/p300 ligand 2 | CBP/p300 ligand 2 is a ligand for target protein for PROTAC of dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2484741-78-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138539. | |
| CBR-470-1 | CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP+-induced cytotoxicity through activation of the Keap1-Nrf2 cascade[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2416095-06-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134205A. | |
| CBR-5884 | CBR-5884 is an active, selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC50 of 33 ?M. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 681159-27-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100012. | |
| CC-115 | CC-115 is a potent and dual DNA-PK and mTOR kinase inhibitor with IC50s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling. Uses: Scientific research. Group: Signaling pathways. CAS No. 1228013-15-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16962. | |
| CC260 | CC260 is a selective PI5P4K? and PI5P4K? inhibitor with Kis of 40 nM and 30 nM, respectively. CC260 does not inhibit or weakly inhibits other protein kinases, such as Plk1 and RSK2. CC260 can be used for cell energy metabolism, diabetes and cancer research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2411088-26-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139188. | |
| CC-3060 | CC-3060 is a Cereblon modulator that promotes ZBTB16 degradation. CC-3060 degrades ZBTB16 with a DC50 of 0.47 nM in HT-1080 cells. CC-3060 targets ZBTB16 for degradation by primarily engaging distinct structural degrons on different zinc finger domains[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 444288-86-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-153698. | |
| CC-401 hydrochloride | CC-401 hydrochloride is a potent inhibitor of all three forms of JNK with Ki of 25 to 50 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CC401 HCl. CAS No. 1438391-30-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13022. | |
| CC-671 | CC-671 is a dual TTK protein kinase/CDC2-like kinase (CLK2) inhibitor with IC50s of 0.005 and 0.006 ?M for TTK and CLK2, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1618658-88-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108709. | |
| CC-885 | CC-885 is a cereblon (CRBN) modulator with potent anti-tumour activity. CC-885 is also a known degrader of GSPT1, inhibiting protein translation. Uses: Scientific research. Group: Signaling pathways. CAS No. 1010100-07-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101488. | |
| CC-90001 | CC-90001 is a potent, selective and orally active inhibitor of c-Jun N-terminal kinase (JNK). CC-90001 shows 12.9-fold selectivity for JNK1 over JNK2 in a cell-based model. CC-90001 can be used for the research of idiopathic pulmonary fibrosis[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1403859-14-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138304. | |
| CC-90002 | CC-90002 is a humanized anti-CD47 monoclonal antibody (mAb). CC-90002 has a high affinity for binding to CD47 with a subnanomolar K d value. CC-90002 can be used for the research of hematologic malignancies and solid tumors [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2085844-54-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99172. | |
| CC-90003 | CC-90003 is an irreversible and selective inhibitor of ERK 1/2 with antitumor activity. Uses: Scientific research. Group: Signaling pathways. CAS No. 1621999-82-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112570. | |
| CC-90005 | CC-90005 is a potent, selective and orally active inhibitor of protein kinase C-? (PKC-?), with an IC50 of 8 nM. CC-90005 shows selectivity for PKC-? over PKC-? (IC50=4440 nM). CC-90005 can inhibit T cell activation by inhibiting IL-2 expression[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1799574-70-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132304. | |
| CCCP | CCCP is an oxidative phosphorylation ( OXPHOS ) uncoupler. CCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Carbonyl cyanide 3-chlorophenylhydrazone; Carbonyl Cyanide m-Chlorophenylhydrazone. CAS No. 555-60-2. Pack Sizes: 10 mM * 1 mL; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-100941. | |
| ccc_R08 | ccc_R08 is a non-cytotoxic and orally active cccDNA inhibitor that reduces cccDNA levels in the liver of HBV-infected mice. ccc_R08 can be used in the study of HBV virus (hepatitis B virus) infection[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2919019-72-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148560. | |
| CCD Lipid01 | CCD Lipid01 is a cationic lipid used in the delivery of biologically active agents to cells and tissues[1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 1799316-64-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-46760. | |
| CCF642 | CCF642 is a potent protein disulfide isomerases (PDI) inhibitor with an IC50 of 2.9 ?M. CCF642 causes acute endoplasmic reticulum (ER) stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. CCF642 has broad anti-multiple myeloma activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 346640-08-2. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100430. | |
| CCG-1423 | CCG-1423 is an inhibitor of Rho/MRTF/SRF pathway. CCG-1423 shows activities in several cancer cells. CCG-1423 is a promising lead compound for the development of novel pharmacologic tools, and it can be used for the research of cancer and diabetes [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 285986-88-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13991. | |
| CCG-203971 | CCG-203971 is a second-generation Rho/MRTF/SRF pathway inhibitor. CCG-203971 potently targets RhoA/C-activated SRE-luciferase (IC50 =6.4 ?M). CCG-203971 inhibits PC-3 cell migration with an IC50 of 4.2 ?M. Potential anti-metastasis Agent[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1443437-74-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108361. | |
| CCG258208 hydrochloride | CCG258208 (GRK2-IN-1) hydrochloride is a potent and selective GRK2 (G protein-coupled receptor kinase 2) inhibitor (IC50=30 nM) while maintaining 230-fold selectivity over GRK5 (IC50=7.09 ?M) and more than 2500-fold selectivity over GRK1 (IC50=87.3 ?M), PKA, and ROCK1. CCG258208 hydrochloride can be used in heart failure research[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GRK2-IN-1 hydrochloride. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109562A. | |
| CCG273441 | CCG273441 is a covalent inhibitor of G protein-coupled receptor ( GPCR ) kinase 5 ( GRK5 ) with an IC 50 value of 3.8 nM. CCG273441 is highly selective to GRK5 over GRK2 (IC 50 =4.8 μM) by binding Cys474, a GRK5 subfamily-specific residue, as a covalent handle [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2750414-35-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-47573. | |
| CCG-63802 | CCG-63802 is a selective, reversible and allosteric RGS4 inhibitor. CCG-63802 specifically binds to RGS4 and blocks the RGS4-G?o interaction, with an IC50 value of 1.9 ?M[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 620112-78-9. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-70074. | |
| CCMI | CCMI (AVL-3288) is a potent and selective α7 nAChR -positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. CCMI has potential in CNS diseases with cognitive dysfunction [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AVL-3288; UCI-4083. CAS No. 917837-54-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-12150. | |
| CCPA | CCPA (2-Chloro-N6-cyclopentyladenosine) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis , etc [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2-Chloro-N6-cyclopentyladenosine. CAS No. 37739-05-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103185. | |
| CCR6 antagonist 1 | CCR6 antagonist 1 is a CCR6 antagonist that inhibits the CCL20/CCR6 axis. CCR6 antagonist 1 can be used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 588674-64-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151435. | |
| CCR6 inhibitor 1 | CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC50s of 0.45 and 6 nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC50, > 30000 nM), and CCR7 (IC50, 9400 nM). CCR6 inhibitor 1 markedly blocks ERK phosphorylation. CCR6 inhibitor 1 is used in the research of autoimmune diseases and cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2437547-04-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112701. | |
| CCT018159 | CCT018159, a 3,4-diaryl pyrazoleresorcinol, is a ATP-competitive HSP90 ATPase activity inhibitor with IC50s of 3.2 and 6.6 μM for human Hsp90? and yeast Hsp90, respectively. CCT018159 caused cell cytostasis associated with a G1 arrest and induces apoptosis. CCT018159 inhibits key endothelial and tumor cell functions implicated in invasion and angiogenesis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 171009-07-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-110042. | |
| CCT020312 | CCT020312 is a selective EIF2AK3/PERK activator. CCT020312 elicits EIF2A phosphorylation in cells. Uses: Scientific research. Group: Signaling pathways. CAS No. 324759-76-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119240. | |
| CCT128930 | CCT128930 is a ATP-competitive and selective inhibitor of AKT (IC50=6 nM for AKT2). CCT128930 has 28-fold selectivity over the closely related PKA kinase (IC50=168 nM) through the targeting of Met282 of AKT (Met173 of PKA-AKT chimera), as well as 20-fold selectivity over p70S6K (IC50=120 nM). Antitumor activity. Uses: Scientific research. Group: Signaling pathways. CAS No. 885499-61-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13260. | |
| CCT129957 | CCT129957 is an indole derivative and a potent phospholipase C-? (PLC-?) inhibitor with an IC50 of ~3 ?M and a GC50 of 15 ?M. CCT129957 inhibits Ca2+ release in squamous carcinoma cells at ~15 ?M[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 883098-58-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111208. | |
| CCT241533 hydrochloride | CCT241533 hydrochloride is a potent and selective CHK2 inhibitor with an IC 50 of 3 nM and a K i of 1.16 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1431697-96-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14715B. | |
| CCT245232 | CCT245232 is a potent inhibitor of heat shock factor 1 ( HSF1 ). HSF1 is the master regulator of the heat shock response, in which multiple genes are induced in response to temperature increase and other stresses. CCT245232 has the potential for the research of proliferative diseases, such as cancer (extracted from patent WO2015049535A1) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1693731-14-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144867. | |
| CCT245737 | CCT245737 (SRA737) is an orally active and seletive Chk1 inhibitor, with an IC50 of 1.3 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SRA737. CAS No. 1489389-18-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18958. | |
| CCT251236 | CCT251236 is an orally available pirin ligand from a heat shock transcription factor 1 (hsf1) phenotypic screen with an IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction. Uses: Scientific research. Group: Signaling pathways. CAS No. 1693731-40-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101026. | |
| CCT251545 | CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with an IC50 of 5 nM in 7dF3 cells[1]. CCT251545 is a selective chemical probe for exploring the role of CDK8 and CDK19 in human disease[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1661839-45-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12681. | |
| CCT-251921 | CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor with an IC50 of 2.3 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1607837-31-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19984. | |
| CCT374705 | CCT374705 is an orally active BCL6 inhibitor with potent antiproliferative effects in vitro. CCT374705 effectively inhibits tumor growth in a lymphoma xenograft mouse model [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2640647-90-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153521. | |
| CD1530 | CD1530 is an orally active, selective RAR? agonist and antibacterial agent. CD1530 reduces Smad1/5/8 phosphorylation and overall Smad levels. CD1530 reduces ?-catenin, MMP9 protein, and ROS levels. CD1530 exhibits activities such as inhibiting heterotopic ossification, promoting Achilles tendon healing, and inhibiting muscle fatty infiltration. CD1530 can be used in the research of orthopedic diseases (such as heterotopic ossification, Achilles tendon injury), muscle diseases (such as muscle fatty infiltration-related diseases)[1][2][3][4][5][6]. Uses: Scientific research. Group: Signaling pathways. CAS No. 107430-66-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108527. | |
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