MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Dabrafenib Mesylate | Dabrafenib Mesylate is a potent and selective Raf kinase inhibitor with IC 50 s of 0.6 and 5.0 nM for Raf V600E and c-Raf, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK2118436 Mesylate; GSK 2118436B. CAS No. 1195768-06-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-14660A. |  |
| DACA | DACA inhibits two essential nuclear enzymes in vitro, DNA topoisomerase I and DNA topoisomerase (topo) II. DACA stabilises topo I, topo II alpha, and topo II beta cleavable complexes in human leukaemia CCRF-CEM cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 89459-25-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100777. | |
| Dacarbazine | Dacarbazine is a nonspecific antineoplastic ( antineoplastic ) alkylating agent. Dacarbazine inhibits T and B lymphocyte responses with IC 50 of 50 and 10 μg/mL, respectively. Dacarbazine can be used in the study of metastatic malignant melanoma [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Imidazole Carboxamide. CAS No. 4342-3-4. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 1 g. Product ID: HY-B0078. | |
| Dacetuzumab | Dacetuzumab (SGN-40) is a humanized IgG1, anti-CD40 monoclonal antibody with anti-lymphoma activity. Dacetuzumab kills tumor cells via immune effector functions (antibody-dependent cellular cytotoxicity and phagocytosis [ADCC/ADCP]). Dacetuzumab ((SGN-40) can be used for multiple myeloma research [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 880486-59-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99015. | |
| Daclatasvir | Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC 50 s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC 50 s of 1.5 μM and 3.27 μM, respectively [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-790052; EBP 883. CAS No. 1009119-64-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10466. | |
| Daclatasvir dihydrochloride | Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) is a potent and orally active HCV NS5A protein inhibitor with EC 50 s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir dihydrochloride is also an organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC 50 s of 1.5 μM and 3.27 μM, respectively [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-790052 dihydrochloride; EBP 883 dihydrochloride. CAS No. 1009119-65-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10465. | |
| Daclizumab | Daclizumab (Zenapax) is a humanized, monoclonal antibody that blocks CD25 (α-subunit of the high-affinity interleukin-2 receptor (IL-2R-HA)). Daclizumab (Zenapax) reversibly binds to CD25and prevents the interaction of IL-2 with the IL-2R-HA. Daclizumab (Zenapax) can be used for multiple sclerosis research [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Zenapax; Ro 24-7375. CAS No. 152923-56-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-108738. | |
| DACM | DACM (N-(7-Dimethylamino-4-methyl-3-coumarinyl)maleimide) is a thiol-directed fluorescent dye (Ex=396 nm, Em=468 nm) [1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: N-(7-Dimethylamino-4-methyl-3-coumarinyl)maleimide. CAS No. 55145-14-7. Pack Sizes: 1 mg. Product ID: HY-121030. | |
| Dacomitinib | Dacomitinib (PF-00299804) is a specific and irreversible inhibitor of the ERBB family of kinases with IC 50 s of 6 nM, 45.7 nM and 73.7 nM for EGFR , ERBB2 , and ERBB4 , respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-00299804; PF-299804. CAS No. 1110813-31-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13272. | |
| Dacomitinib hydrate | Dacomitinib (PF-00299804) hydrate is an orally active, irreversible pan- ErbB inhibitor. Dacomitinib hydrate can be used in the research of cancers such as metastatic non-small cell lung cancer (NSCLC) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-00299804 hydrate; PF-299804 hydrate. CAS No. 1042385-75-0. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-118263. | |
| Dactylorhin A | Dactylorhin A, a succinate derivative ester, is isolated from rhizomes of Gymnadenia conopsea. Dactylorhin A exhibits moderate inhibitory effects on NO production effects in RAW 264.7 macrophage cells [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 256459-34-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-125531. | |
| DAF-FM | DAF-FM is a diaminofluorescein, which can be used as fluorescent indicator for nitric oxide (NO) with good pH tolerance [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 254109-20-1. Pack Sizes: 1 mg. Product ID: HY-126774. | |
| DAF-FM DA | DAF-FM DA (Diaminofluorescein-FM diacetate) is a fluorescent probe for the detection and bioimaging of nitric oxide (NO). DAF-FM DA spontaneously crosses the plasma membrane and is subsequently cleaved by esterases to generate intracellular DAF-FM (Ex/Em=495/515 nm) [1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Diaminofluorescein-FM diacetate. CAS No. 254109-22-3. Pack Sizes: 100 μg; 500 μg; 1 mg; 5 mg. Product ID: HY-D0717. | |
| Dagrocorat | Dagrocorat (PF-00251802) is an orally active and selective high-affinity partial agonist of the glucocorticoid receptor. Dagrocorat is also a time-dependent reversible inhibitor of CYP3A ( IC 50 =1.3 μM in human liver microsomes) and CYP2D6 ( K i =0.57 μM in human liver microsomes). Dagrocorat can be used for the research of rheumatoid arthritis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-00251802. CAS No. 1044535-52-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16718. | |
| Dagrocorat hydrochloride | Dagrocorat (PF-00251802) hydrochloride is an orally active and selective high-affinity partial agonist of the glucocorticoid receptor. Dagrocorat hydrochloride is also a time-dependent reversible inhibitor of CYP3A ( IC 50 =1.3 μM in human liver microsomes) and CYP2D6 ( K i =0.57 μM in human liver microsomes). Dagrocorat hydrochloride can be used for the research of rheumatoid arthritis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-00251802 hydrochloride. CAS No. 1044535-61-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16718A. | |
| Daidzein | Daidzein is a soy isoflavone, which acts as a PPAR activator. Uses: Scientific research. Group: Natural products. CAS No. 486-66-8. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-N0019. | |
| Daidzein (Standard) | Daidzein (Standard) is the analytical standard of Daidzein. This product is intended for research and analytical applications. Daidzein is a soy isoflavone, which acts as a PPAR activator. Uses: Scientific research. Group: Natural products. CAS No. 486-66-8. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-N0019R. | |
| Daidzin | Daidzin is an isoflavone with antioxidant, anticancer, and antiatherosclerotic activities. Daidzin is a potent and selective inhibitor of mitochondrial ALDH-2. Daidzin reduces ethanol consumption [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Daidzoside; NPI-031D; Daidzein 7-O-glucoside. CAS No. 552-66-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-N0018. | |
| D-Ala-D-Ala | D-Ala-D-Ala is a bacterial endogenous metabolite. D-Ala-D-Ala constitutes the terminus of the peptide part of the peptidoglycan monomer unit and is involved in the transpeptidation reaction as the substrate. D-Ala-D-Ala is catalyzed by D-Alanine-D-Alanine ligase [1] [2] [3]. Uses: Scientific research. Group: Peptides. CAS No. 923-16-0. Pack Sizes: 100 mg; 250 mg; 1 g; 5 g. Product ID: HY-W015450. | |
| D-Alanine | D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC 50 of 9 mM for GlyR [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (R)-Alanine; Ba 2776; D-α-Alanine. CAS No. 338-69-2. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g. Product ID: HY-41700. | |
| D-Alanine ethyl ester hydrochloride | D-Alanine ethyl ester hydrochloride is an alanine derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 6331-9-5. Pack Sizes: 1 g. Product ID: HY-W017350. | |
| D-Alaninol | H-D-Alaninol is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 35320-23-1. Pack Sizes: 25 g. Product ID: HY-W010646. | |
| Dalbavancin hydrochloride | Dalbavancin hydrochloride (MDL-63397 hydrochloride) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin hydrochloride inhibits Staphylococcus aureus and Bacillus anthracis with MIC 90 s of 0.06 μg/mL and 0.25 μg/mL, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MDL-63397 hydrochloride; BI-397 hydrochloride. CAS No. 2227366-51-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17586. | |
| Dalcetrapib | Dalcetrapib (JTT-705) is an orally active cholesteryl ester transfer protein (CETP) inhibitor with IC 50 s of 204.6 nM and 6 μM against recombinant human (rh) CETP and human plasma CETP, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: JTT-705; RO4607381. CAS No. 211513-37-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-14950. | |
| Dalfopristin | Dalfopristin (RP54476) is a semisynthetic sulfone antibiotic. Dalfopristin alone has limited antibacterial activity, but synergistically with Quinupristin it has significant bactericidal activity against many pathogenic Gram-positive cocci [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RP54476. CAS No. 112362-50-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-A0241. | |
| D-Alloisoleucine | D-Alloisoleucine is an isoleucine derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 1509-35-9. Pack Sizes: 5 g; 10 g; 25 g; 100 g. Product ID: HY-78912. | |
| D-Allose | D-Allose is an endogenous metabolite. Uses: Scientific research. Group: Natural products. CAS No. 2595-97-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg. Product ID: HY-128741. | |
| D-Allothreonine | D-Allothreonine is the D type stereoisomer of Allothreonine. D-Allothreonine is a peptido-lipid derived from bacteria. D-Allothreonine, amide-linked to the D-galacturonic acid, is also a constituent in the polysaccharide [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 24830-94-2. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-W001959. | |
| Dalosirvat | Dalosirvat (SM-04554) is a potent Wnt activator extracted from patent WO2012024404A1, compound 1, has an EC 50 s of 28-29 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SM-04554; Wnt pathway activator 1. CAS No. 1360540-81-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-135516. | |
| Dalotuzumab | Dalotuzumab (MK-0646) is a recombinant humanized monoclonal antibody (IgG1 type) targeting IGF-1R. Dalotuzumab acts by inhibiting IGF-1 - and IGF-2 -mediated tumor cell proliferation, IGF-1R autophosphorylation, and Akt phosphorylation. Dalotuzumab also induces apoptosis and cycle arrest. Dalotuzumab in combination with other anticancer agents such as statins can enhance the antitumor activity of Dalotuzumab in vitro and in vivo [1] [2] [3]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MK-0646; h7C10. CAS No. 1005389-60-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99284. | |
| D-α-Tocopherol acetate | D-α-Tocopherol acetate (D-Vitamin E acetate) can be hydrolyzed to d-alpha-tocopherol (VE) and absorbed in the small intestine [1]. Uses: Scientific research. Group: Natural products. Alternative Names: D-Vitamin E acetate. CAS No. 58-95-7. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g; 10 g; 25 g; 50 g. Product ID: HY-B1278. | |
| D-α-Tocopherol Succinate | D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Vitamin E succinate. CAS No. 4345-3-3. Pack Sizes: 100 mg; 250 mg; 500 mg. Product ID: HY-131553. | |
| D-α-Tocopherylquinone | D-α-Tocopherylquinone (α-Tocopherylquinone) is a quinone, can be isolated from Phaeodactylum tricornutum. D-α-Tocopherylquinone is a oxidation product of α-Tocopherol (vitamin E). D-α-Tocopherylquinone can act as an anticoagulant and as an antioxidant [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: α-Tocopherylquinone. CAS No. 7559-4-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-N2853. | |
| Dalpiciclib | Dalpiciclib (SHR-6390) is an orally active and highly selective inhibitor of CDK4 and 6 with IC 50 values of 12.4 nM and 9.9 nM, respectively [1] [2]. Dalpiciclib shows antitumor activity against breast cancer and esophageal squamous cell carcinoma [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SHR-6390. CAS No. 1637781-04-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-114338. | |
| Dalpiciclib hydrochloride | Dalpiciclib (SHR-6390) hydrochloride is an orally active and highly selective inhibitor of CDK4 and 6 with IC 50 values of 12.4?nM and 9.9?nM, respectively [1] [2]. Dalpiciclib hydrochloride shows antitumor activity against breast cancer and esophageal squamous cell carcinoma [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SHR-6390 hydrochloride. CAS No. 2891598-76-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114338A. | |
| Dalutrafusp alfa | Dalutrafusp alfa (AGEN-1423; GS-1423) is a specific bifunctional antibody against CD73 and TGF-β , which is involved in the immunosuppressive pathway [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: AGEN-1423; GS-1423. CAS No. 2419918-89-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99841. | |
| Damascenone | Damascenone ((E/Z)-Damascenone) is an active compound of Epipremnum pinnatum with anti-inflammatory activity [1]. Damascenone is a mixture complex of E-isomer-Damascenone and Z-isomer Damascenone. Uses: Scientific research. Group: Natural products. Alternative Names: (E/Z)-Damascenone. CAS No. 23696-85-7. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-N2543. | |
| DAMGO | DAMGO is a μ-opioid receptor ( μ-OPR ) selective agonist with a K d of 3.46 nM for native μ-OPR [1]. Uses: Scientific research. Group: Peptides. CAS No. 78123-71-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0210. | |
| DAMGO TFA | DAMGO TFA is a μ-opioid receptor ( μ-OPR ) selective agonist with a K d of 3.46 nM for native μ-OPR [1]. Uses: Scientific research. Group: Peptides. CAS No. 950492-85-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-P0210B. | |
| D-Amino acid oxidase (Immobilized) | D-Amino acid oxidase is an enzyme to metabolize exogenous D-amino acids in animals for detoxifying action. D-Amino acid oxidase also modulates the level of D-serine in brain [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9000-88-8. Pack Sizes: 25 U. Product ID: HY-P2986. | |
| Daminozide | Daminozide, a plant growth regulator, is a selective inhibitor of the human KDM2/7 histone demethylases , with IC 50 s of 0.55, 1.5 and 2.1 μM for PHF8 , KDM2A , and KIAA1718 , respectively. Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 1596-84-5. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-13643. | |
| Damnacanthal | Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56 lck tyrosine kinase activity. Natural Damnacanthal inhibits p56 lck autophosphorylation and phosphorylation of exogenous substrates with IC 50 s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti-inflammatory effects in mice and anti-fungal activity against Candida albicans [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 477-84-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-108485. | |
| Danavorexton | Danavorexton (TAK-925) is an orexin receptor agonist with brain permeability. Danavorexton induces a physiological pattern of OX2R activation in vitro to wake up sleepy mice and improve sleepiness symptoms [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TAK-925. CAS No. 2114324-48-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133898. | |
| Danazol | Danazol inhibits the proliferation of cancer cell MDA-MB-231 and MCF-7 with IC 50 of 65 μg/mL and 31 μg/mL. Danazol arrests the cell cycle at G1 phase, induces apoptosis in MDA-MB-231 through PKCα signaling pathway [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 17230-88-5. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg. Product ID: HY-B1029. | |
| Danicopan | Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with K d value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ACH-4471. CAS No. 1903768-17-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117930. | |
| Danofloxacin | Danofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent. Danofloxacin shows a broad spectrum of activity against most Gram-negative and Gram-positive bacteria , mycoplasma and chlamydia species , and plays an antimicrobial role by inhibition of bacterial DNA-gyrase. Danofloxacinh has the potential for respiratory diseases in cattle, swine, and chickens treatment [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 112398-08-0. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-W011117. | |
| Danofloxacin mesylate | Danofloxacin mesylate (CP 76136-27) is a fluoroquinolone used as a veterinary drug. Danofloxacin mesylate has a broad spectrum of bactericidal activity, mainly inhibiting the DNA cycloenzyme of the bacteria. In addition, Danofloxacin mesylate is a substrate for ATP-dependent efflux transporters ( P-gp and MRP2 ) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CP 76136-27. CAS No. 119478-55-6. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B0501. | |
| Danoprevir | Danoprevir (ITMN-191) is an orally active NS3/4A protease inhibitor for hepatitis C virus (HCV) with an IC 50 of 0.29 nM and is selective for NS3/4A over a panel of 53 proteases ( IC 50 higher than 10 μM). Danoprevir (ITMN-191) inhibits HCV genotypes 1a, 1b, 4, 5, and 6 ( IC 50 s=0.2-0.4 nM) as well as 2b and 3a ( IC 50 s=1.6, 3.5 nM) [1] [2]. Danoprevir is also a SARS-CoV 3CL pro inhibitor with an IC 50 of 0.05 μM [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ITMN-191; R7227; RO5190591; RG7227. CAS No. 850876-88-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10238. | |
| Danshensu | Danshensu (Dan shen suan A), an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu reduces reactive oxygen species ( ROS ) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu displays a potent antiviral activity against SARS-CoV-2 with EC 50 of 0.97?μM. Danshensu has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Dan shen suan A; Salvianic acid A. CAS No. 76822-21-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N1913. | |
| Danshensu sodium | Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu sodium reduces reactive oxygen species ( ROS ) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu sodium displays a potent antiviral activity against SARS-CoV-2 with EC 50 of 0.97?μM. Danshensu sodium has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Dan shen suan A sodium; Salvianic acid A sodium. CAS No. 81075-52-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N1913A. | |
| Dansyl chloride | Dansyl chloride is a reagent that produces stable blue or blue-green fluorescent sulfonamide adducts in the reaction of aliphatic and aromatic amines with primary amino groups, and is widely used for modified amino acids, protein sequencing and amino acid analysis [1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: DNSCl. CAS No. 605-65-2. Pack Sizes: 1 g; 5 g; 10 g. Product ID: HY-D0017. | |
| Dansyl hydrazine | 5-(Dimethylamino)naphthalene-1-sulfonohydrazide is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 33008-06-9. Pack Sizes: 1 g; 5 g. Product ID: HY-W009411. | |
| Danthron | Danthron is a natural product extracted from the traditional Chinese medicine Salvia miltiorrhiza Bunge. Danthron functions in regulating glucose and lipid metabolism by activating AMPK. Uses: Scientific research. Group: Natural products. Alternative Names: Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone. CAS No. 117-10-2. Pack Sizes: 10 mM * 1 mL; 100 mg; 1 g; 5 g. Product ID: HY-B0923. | |
| Dantrolene | Dantrolene is an orally active, non-competitive glutathione reductase inhibitor with a K i of 111.6 μM and an IC 50 of 52.3 μM. Dantrolene is also a calcium channel protein inhibitor. Dantrolene inhibits the release of Ca 2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: F 368. CAS No. 7261-97-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12542. | |
| Dantrolene sodium | Dantrolene sodium is an orally active, non-competitive glutathione reductase inhibitor with a K i of 111.6 μM and an IC 50 of 52.3 μM. Dantrolene sodium is also a calcium channel protein inhibitor. Dantrolene sodium inhibits the release of Ca 2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene sodium offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: F 440. CAS No. 14663-23-1. Pack Sizes: 100 mg; 500 mg. Product ID: HY-14657. | |
| Dantrolene sodium hemiheptahydrate | Dantrolene sodium hemiheptahydrate is an orally active, non-competitive glutathione reductase inhibitor with a K i of 111.6 μM and an IC 50 of 52.3 μM. Dantrolene sodium hemiheptahydrate is also a calcium channel protein inhibitor. Dantrolene sodium hemiheptahydrate inhibits the release of Ca 2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene sodium hemiheptahydrate offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Dantrolene sodium hydrate. CAS No. 24868-20-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-12542A. | |
| Danuglipron | Danuglipron (PF-06882961) is an orally active glucagon-like peptide-1 receptor (GLP-1R) agonist. Danuglipron has the potential for type 2 diabetes research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-06882961. CAS No. 2230198-02-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125824. | |
| DAOS | DAOS, a Trinder's reagent, is a novel highly water-soluble aniline derivative; are widely used in diagnostic tests and biochemical tests. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 83777-30-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg. Product ID: HY-15913. | |
| D-AP5 | D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a K d of 1.4 μM. D-AP5 (D-APV) inhibits the glutamate binding site of NMDA receptors [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: D-APV; D-2-Amino-5-phosphonovaleric acid. CAS No. 79055-68-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100714A. | |
| Dapagliflozin | Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 ( SGLT2 ) inhibitor, which results in excretion of glucose into the urine [1]. Dapagliflozin induces HIF1 expression and attenuates renal IR injury [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-512148. CAS No. 461432-26-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10450. | |
| Dapagliflozin-3-O-β-D-glucuronide | Dapagliflozin-3-O-β-D-glucuronide (BMS-801576) is the metabolite of Dapagliflozin (HY-10450), and is formed in the liver and kidney by uridine diphosphate glucuronosyltransferase-1A9 (UGT1A9). Dapagliflozin is a selective inhibitor for SGLT2 , that can be used to improve glycemic control and attenuate type 2 diabetes [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-801576. CAS No. 1351438-75-9. Pack Sizes: 500 μg; 1 mg. Product ID: HY-125156. | |
| Dapagliflozin impurity | Dapagliflozin impurity is an enantiomer of Dapagliflozin which is a sodium-glucose transporter 2 inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 960404-86-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-128723. | |
| Dapansutrile | Dapansutrile is a potent, orally active and selective NLRP3 inflammasome inhibitor. Dapansutrile has anti-inflammatory activity and decreases immune factor levels. Dapansutrile can be used for research of inflammatory diseases [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: OLT1177. CAS No. 54863-37-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17629. | |
| Daphnetin | Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne , is a potent, oral active protein kinase inhibitor, with IC 50 s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1 , ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: 7,8-Dihydroxycoumarin. CAS No. 486-35-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0281. | |
| DAPI dihydrochloride | DAPI dihydrochloride is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. In addition, because DAPI can pass through intact cell membranes, it can be used to stain both live and fixed cells [1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: 4',6-Diamidino-2-phenylindole dihydrochloride. CAS No. 28718-90-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-D0814. | |
| DAPI (dihydrochloride) (solution) | DAPI dihydrochloride (4',6-Diamidino-2-phenylindole dihydrochloride) (solution) is a DAPI dye. DAPI is a fluorescent dye that can bind strongly to DNA. DAPI binds to the A/T base pairs in the minor groove of double-stranded DNA (1 DAPI molecule can occupy 3 base pairs), which amplifies the fluorescence intensity by about 20 times. By observing the fluorescence intensity, DNA can be quantified. DAPI can also penetrate intact cell membranes and is often used to stain living and fixed cells [1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: 4',6-Diamidino-2-phenylindole dihydrochloride (solution). CAS No. 28718-90-3. Pack Sizes: 500 μg (28.55 μM * 50 mL in DDH2O); 5 mg (28.55 μM * 500 mL in DDH2O). Product ID: HY-D0814A. | |
| DAPI dilactate | DAPI (dilactate) is a blue fluorescent dye that preferentially binds dsDNA and binds to minor groove AT clusters. DAPI (dilactate) is combined with dsDNA, and the fluorescence was enhanced about 20-fold. DAPI (dilactate) can be used to identify the cell cycle and specifically stains the nucleus but not the cytoplasm. DAPI (dilactate) form is more soluble in water than DAPI (dihydrochloride) form. [1] [2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: 4',6-Diamidino-2-phenylindole dilactate. CAS No. 28718-91-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D1738. | |
| Dapiglutide | Dapiglutide (ZP7570) is a long-acting glucagon-like peptide-1 receptor 1R (GLP-1R)/Glucagon-like peptide-2 receptor (GLP-2R) dual agonist. Dapiglutide alleviates intestinal dysfunction in a mouse short bowel model and has anti-obesity effects [1] [2] [3]. Uses: Scientific research. Group: Peptides. Alternative Names: ZP7570. CAS No. 2296814-85-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3291. | |
| Dapiprazole hydrochloride | Dapiprazole hydrochloride is a potent, selective and orally active alpha-1 adrenoceptor antagonist. Dapiprazole hydrochloride suppresses the opioid withdrawal symptoms. Dapiprazole hydrochloride is also used as eye drops for reversing mydriasis [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 72822-13-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0142A. | |
| Dapirolizumab | Dapirolizumab is a monoclonal antibodi against CD40 ligand. Dapirolizumab targets CD40L, blocks its interaction with CD40 receptors, and inhibits adaptive immune activation. Dapirolizumab attenuates systemic lupus erythematosus [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 1416147-64-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99842A. | |
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