BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| CBP-iminomethylenevancomycin | CBP-iminomethylenevancomycin is an analogue of vancomycin which overcomes the drug resistance and induces cell permeability. It significantly increases the antibacterial activity and decreases the side effects. Uses: Antibacterial agent. Synonyms: CBP iminomethylenevancomycin. |  |
| CBS9106 (BMS566419) | Cas No. 1076235-04-5. | |
| CC0651 | CC0651, a Cdc34 ubiquitin-conjugating enzyme allosteric inhibitor, has been found to restrain the cell proliferation at some extent in cancer cell lines PC-3. IC50: 1.72 uM (inhibited the ubiquitination of p27 Kip1). Uses: Cc0651 is a cdc34 ubiquitin-conjugating enzyme allosteric inhibitor that has been found to restrain the cell proliferation at some extent in cancer cell lines pc-3. ic50: 1.72 um (inhibited the ubiquitination of p27 kip1). Synonyms: CC0651;CC 0651; CC-0651; (2R, 3S, 4S)-5-[4-(3, 5-dichlorophenyl)phenyl]-2, 3-dihydroxy-4-[(2-methoxyacetyl)amino]pentanoicacid; CC0651; 1319207-44-7; 4, 5-Dideoxy-5-(3', 5'-Dichlorobiphenyl-4-Yl)-4-[(Methoxyacetyl)amino]-L-ArabinonicAcid; U94; SCHEMBL14884531. Grades: 95%. CAS No. 1319207-44-7. Molecular formula: C20H21Cl2NO6. Mole weight: 442.29. | |
| CC-115 | CC-115, a DNA-PK and mTOR inhibitor, has been found to have probable anticarcinoma effect. IC50:13 nM and 21 nM for DNA-PK and mTOR respectively. Uses: Cc-115 is a dna-pk and mtor inhibitor and has been found to have probable anticarcinoma effect. Synonyms: 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one; CC115 ; CC-115; CC 115. Grades: 98%. CAS No. 1228013-15-7. Molecular formula: C16H16N8O. Mole weight: 336.35. | |
| CC-115 hydrochloride | The hydrochloride salt form of CC-115 which is a mTOR / DNA-PK inhibitor that probably has antineoplastic effect through influencing the cellular proliferation of cancer cells. IC50: 21 nM and 13 nM for mTOR and DNA-PK respectively. Uses: The hydrochloride salt form of cc-115 which is a mtor / dna-pk inhibitor that probably has antineoplastic effect through influencing the cellular proliferation of cancer cells. Synonyms: CC115 hydrochloride ; CC-115 hydrochloride; CC 115 hydrochloride. Grades: 98%. CAS No. 1300118-55-1. Molecular formula: C16H17ClN8O. Mole weight: 372.81. | |
| CC-90002 | CC-90002 is a humanized anti-CD47 monoclonal antibody. CC-90002 binds to CD47 and inhibits CD47-SIRPα interaction. CC-90002 has been used in the research of acute myeloid leukemia. Synonyms: CC 90002; CC90002. CAS No. 2085844-54-6. | |
| CCG-1423 | CCG-1423 is a potent inhibitor of RhoA/C-mediated gene transcription. It suppressed invasion of PC-3 prostate cancer cells in a matrigel model of metastasis. It induces intermediate mesoderm differentiation from ESCs. Synonyms: CCG 1423; N-[1-(4-chloroanilino)-1-oxopropan-2-yl]oxy-3,5-bis(trifluoromethyl)benzamide. Grades: >98%. CAS No. 285986-88-1. Molecular formula: C18H13ClF6N2O3. Mole weight: 454.75. | |
| CCG-224406 | CCG-224406 is a highly selective and potent inhibitor of G Protein-Coupled Receptor Kinase 2 (IC50= 130 nM), with 700-fold selectivity over other GRK subfamilies, and no detectable inhibition of ROCK1. Synonyms: CCG 224406; CCG224406; N-(1H-Indazole-5-yl)-2-oxo-4-[3-(2,6-dimethoxybenzylcarbamoyl)-4-fluorophenyl]-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide. Grades: >98%. CAS No. 1870843-22-3. Molecular formula: C29H27FN6O5. Mole weight: 558.57. | |
| CCT244747 | CCT244747 is a novel potent, highly selective, orally active ATP-competitive CHK1 inhibitor with potential anticancer activity. CCT244747 inhibited cellular CHK1 activity (IC(50) 29-170 nmol/L), significantly enhanced the cytotoxicity of several anticancer drugs, and abrogated drug-induced S and G(2) arrest in multiple tumor cell lines. CCT244747 represents the first structural disclosure of a highly selective, orally active CHK1 inhibitor and warrants further evaluation alone or combined with genotoxic anticancer therapies. Synonyms: CCT-244747; CCT 244747; 3-{[(2R)-1-(Dimethylamino)-2-propanyl]oxy}-5-{[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino}-2-pyrazinecarbonitrile; 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile; (R)-3-((1-(dimethylamino)propan-2-yl)oxy)-5-((4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)amino)pyrazine-2-carbonitrile. Grades: ≥98%. CAS No. 1404095-34-6. Molecular formula: C20H24N8O2. Mole weight: 408.46. | |
| CCT-251236 | CCT-251236 is an orally active Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen, which exhibited efficacy in a human ovarian carcinoma xenograft model. Uses: The potential treatment of ovarian carcinoma. Synonyms: CCT251236; CCT 251236; N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide; N-[5-(2,3-dihydro-1,4-benzodioxine-6-amido)-2-methylphenyl]-2-[2-(pyrrolidin-1-yl)ethoxy]quinoline-6-carboxamide; 6-Quinolinecarboxamide, N-[5-[[(2,3-dihydro-1,4-benzodioxin-6-yl)carbonyl]amino]-2-methylphenyl]-2-[2-(1-pyrrolidinyl)ethoxy]-. Grades: ≥95%. CAS No. 1693731-40-6. Molecular formula: C32H32N4O5. Mole weight: 552.62. | |
| CDDO-2-P-Im | CDDO-2-P-Im is an orally active inhibitor of necroptosis. Synonyms: CDDO-2P-Im. Grades: 98%. CAS No. 1883650-96-1. Molecular formula: C39H46N4O3. Mole weight: 618.8. | |
| CDDO-3-P-Im | CDDO-3-P-Im is an orally active inhibitor of necroptosis. Synonyms: CDDO-3P-Im. Grades: 98%. CAS No. 1883650-95-0. Molecular formula: C39H46N4O3. Mole weight: 618.8. | |
| CDDO-TFEA | CDDO-TFEA is an Nrf2/ARE pathway activator. CDDO-TFEA inhibits BACH1 via reducing BACH1 nuclear levels while accumulating its cytoplasmic form. Synonyms: 2-cyano-3,12-dioxo-N-(2,2,2-trifluoroethyl)-oleana-1,9(11)-dien-28-amide; CDDO-trifluoroethyl-amide. CAS No. 932730-52-4. Molecular formula: C33H43F3N2O3. Mole weight: 572.7. | |
| CDK4-IN-1 | CDK 4/6 Inhibitor is a part of a group of compounds that exhibits selective inhibitory properties towards Cyclin-Dependent Kinases 4 & 6. These compounds are most commonly used to treat patients with breast cancer. Synonyms: CDK4 IN 1; LEE011 analog; CDK4-IN-1; CDK4IN-1; CDK4-IN1; CDK4IN1; CDK4 IN 1; 4-[5-Chloro-3-(1-methylethyl)-1H-pyrazol-4-yl]-N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-2-pyrimidinamine. Grades: >98%. CAS No. 1256963-02-6. Molecular formula: C22H29ClN8. Mole weight: 440.97. | |
| CDKI-83 | CDKI-83 is a potent CDK9 inhibitor. The compound shows effective anti-proliferative activity in human tumour cell lines with GI50 <1 μM, and is capable of inducing apoptosis in A2780 human ovarian cancer cells as determined by the activated caspase-3, Annexin V/PI double staining and accumulated cells at the sub-G1 phase of cellcycle. The research results suggest that combined inhibition of CDK9 and CDK1 may result in the effective induction of apoptosis and CDKI-83 has the potential to be developed as an anti-cancer agent. Synonyms: CDKI83; CDKI 83. CAS No. 1189558-88-0. Molecular formula: C21H23N7O3S2. Mole weight: 485.58. | |
| CE-224535 | CE-224535 is a Purinergic receptor antagonist originated by Pfizer. Phase-II/III for Rheumatoid arthritis and Phase-II for Osteoarthritis were discontinued. Uses: Osteoarthritis; rheumatoid arthritis. Synonyms: CE-224535; CE 224535; CE224535; CE-224,535; CE 224,535; CE224,535; 2-(4-Chloro-3-(3-(1-hydroxycycloheptyl)propanoyl)phenyl)-4-((2R)-2-hydroxy-3-methoxy-propyl)-1,2,4-triazine-3,5-dione. Grades: 98%. CAS No. 724424-43-5. Molecular formula: C23H30ClN3O6. Mole weight: 480.95. | |
| CE-326597 | CE-326597 is a selective type 1 cholecystokinin receptor (CCK1R)agonist. In Mar 2009, Phase-II for Obesity in World was discontinued. Uses: Obesity. Synonyms: CE-326597; CE326597; CE 326597. (S)-2-(4-((1H-indol-3-yl)methyl)-5-oxo-1-phenyl-4,5-dihydro-6H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-6-yl)-N-benzyl-N-isopropylacetamide. Grades: 98%. CAS No. 870615-40-0. Molecular formula: C37-H34-N6-O2. Mole weight: 594.72. | |
| Ceftolozane | Ceftolozane is a 5th generation cephalosporin antibiotic. It is a semi-synthetic beta-lactam antibiotic and is used for the treatment of infections with gram-negative bacteria, or gram-positive bacteria that have become resistant to conventional antibiotics. It is also used for the treatment of complicated urinary tract infections and complicated intra abdominal infections combined with the β-lactamase inhibitor tazobactam. Uses: Ceftolozane is used for the treatment of infections with gram-negative bacteria, or gram-positive bacteria that have become resistant to conventional antibiotics. it is also used for the treatment of complicated urinary tract infections and complicated in. Synonyms: 7-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-3-[ (5-amino-4-{[(2-aminoethyl)carbamoyl]amino}-1-methyl-1H-pyrazol-2-ium-2-yl)methyl]-3,4-didehydrocepham-4-carboxylate; CXA-101; CXA101. Grades: 98%. CAS No. 689293-68-3. Molecular formula: C23H30N12O8S2. Mole weight: 666.69. | |
| Celecoxib Carboxylic Acid-Acyl-beta-D-Glucuronide | Celecoxib Carboxylic Acid Acyl-β-D-glucuronide is a glucuronide metabolite of Celecoxib, a Cox-2 inhibitor. Synonyms: 1-[4-[1-[4-(Aminosulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl]benzoate] b-D-glucopyranuronic Acid. Grades: > 95%. CAS No. 264236-79-5. Molecular formula: C23H20F3N3O10S. Mole weight: 587.48. | |
| Celiptium | Celiptium, also known as elliptinium acetate, a topoisomerase II inhibitor, is the acetate salt of elliptinium, a derivative of the alkaloid ellipticine isolated from species of the plant family Apocynaceae, including Bleekeria vitensis, a plant with anti-cancer properties. As a topoisomerase II inhibitor and intercalating agent, elliptinium stabilizes the cleavable complex of topoisomerase II and induces DNA breakages, thereby inhibiting DNA replication and RNA and protein synthesis. Check for active clinical trials or closed clinical trials using this agent. Uses: Antineoplastic agents. Synonyms: Ellipticine acetate; Elliptinium acetate; Celiptium; 9-HME; HME; NMHE; 9-hydroxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazol-2-ium acetate. Grades: 98%. CAS No. 58337-35-2. Molecular formula: C20H20N2O3. Mole weight: 336.39. | |
| Cellobiuronic acid | Cellobiuronic acid is a remarkably multifaceted biocompound, standing as an instrumental medicinal compound harnessed to study afflictions of the urinary tract and gastrointestinal disturbances. Synonyms: 4-O-b-D-Glucopyranuronosyl-D-glucose. CAS No. 5551-59-7. Molecular formula: C12H20O12. Mole weight: 356.28. | |
| Cemadotin | Cemadotin is a synthetic analogue of Dolastatin 15 with potent antiproliferative and preclinical antitumor activity. It is also a promising cancer chemotherapeutic agent. Synonyms: LU 103793; LU-103793; LU103793; NSC D-669356; N,N-dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-L-prolinebenzylamide. CAS No. 159776-69-9. Molecular formula: C35H56N6O5. Mole weight: 640.87. | |
| Cemiplimab | Cemiplimab is a PD-1 monoclonal antibody that blocks PD-1/PD-L1-mediated T-cell suppression. Cemiplimab has been approved for the treatment of metastatic cutaneous squamous cell carcinoma (CSCC). Synonyms: Libtayo. CAS No. 1801342-60-8. | |
| Cenegermin | Cenegermin is a recombinant human nerve growth factor that has the healing effect on eye and repair corneal damage. It was granted orphan drug designation in 2015. Uses: Repair corneal damage. CAS No. 1772578-74-1. Molecular formula: C583H908N166O173S8. Mole weight: 13266.94. | |
| CEP-11981 | CEP-11981 is an orally bioavailable inhibitor of vascular endothelial growth factor receptor (VEGFR) and Tie2 receptor tyrosine kinases with potential antiangiogenic and antineoplastic activities. Pan-VEGFR/Tie2 tyrosine kinase inhibitor CEP-11981 selectively binds to VEGFR and Tie2 receptor tyrosine kinases, which may result the inhibition of endothelial cell migration, proliferation and survival and the inhibition of tumor cell proliferation and tumor cell death. VEGFR and Tie2 are frequently overexpressed by a variety of tumor cell types and play crucial roles in the regulation of angiogenesis and the maintenance of tumor blood vessels. Tie2 (tyrosine kinase with immunoglobulin-like and EGF-like domains) is activated by angiopoietin-1 (Ang-1). Synonyms: CEP-11981; CEP 11981; CEP11981. CAS No. 856691-93-5. Molecular formula: C28H27N7O. Mole weight: 477.57. | |
| CEP-1612 | CEP-1612, a dipeptidyl proteasome inhibitor, induces apoptosis and inhibits tumor growth of the human lung cancer cell line A-549 in an in vivo model. Synonyms: N-[(2S)-5-[[amino(nitramido)methylidene]amino]-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]-2-cyclopentyl-10-(1,3-dioxoisoindol-2-yl)decanamide; CEP-1612; CEP 1612; CEP1612; UNII-9K6U075027. Grades: >98%. CAS No. 189036-01-9. Molecular formula: C35H53N7O7. Mole weight: 683.84. | |
| CEP33779 | CEP-33779 is a highly selective, orally active inhibitor of JAK2. It induces regression of established colorectal tumors, angiogenesis, and proliferation of tumor cells. Synonyms: CEP-33779; N-[3-(4-methylpiperazin-1-yl)phenyl]-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine. Grades: >98%. CAS No. 1257704-57-6. Molecular formula: C24H26N6O2S. Mole weight: 462.572. | |
| CEP-5214 | CEP-5214 is a potent, low-nanomolar pan inhibitor of human VEGF-R tyrosine kinases, displaying IC(50) values of 16, 8, and 4 nM for VEGF-R1/FLT-1, VEGF-R2/KDR, and VEGF-R3/FLT-4, respectively, with cellular activity equivalent to the isolated enzyme activity. Compound 21 exhibited good selectivity against numerous tyrosine and serine/threonine kinases including PKC, Tie2, TrkA, CDK1, p38, JNK, and IRK. Synonyms: CEP 5214; CEP5214; 3-(5,6,7,13-tetrahydro-9-((1-methylethoxy)methyl)-5-oxo-12h-indeno(2,1-a)pyrrolo(3,4-c)carbazol-12-yl)propanol; 12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-tetrahydro-5H-indeno[2,1-a]pyrrolo[4,3-c]carbazol-5-one. CAS No. 402857-39-0. Molecular formula: C28H28N2O3. Mole weight: 440.54. | |
| CEP-6800 | CEP-6800 is a potent PARP inhibitor with potential anticancer activity. CEP-6800 could be used as a chemopotentiating agent with a variety of clinically effective chemotherapeutic agents. Synonyms: CEP 6800; CEP6800; 10-(aminomethyl)-4,5,6,7-tetrahydro-1H-cyclopenta[a]pyrrolo[3,4-c]carbazole-1,3(2H)-dione; 8-aminomethyl-1,2,3,11-tetrahydro-5,11-diaza-benzo[a]trindene-4,6-dione. Grades: 98%. CAS No. 609848-02-4. Molecular formula: C18H15N3O2. Mole weight: 305.34. | |
| CEP-7055 | CEP-18770 is An orally bioavailable synthetic P2 threonine boronic acid inhibitor of the chymotrypsin-like activity of the proteasome, with potential antineoplastic activity. Proteasome inhibitor CEP 18770 represses the proteasomal degradation of a variety of proteins, including inhibitory kappaBalpha (IkappaBalpha), resulting in the cytoplasmic sequestration of the transcription factor NF-kappaB; inhibition of NF-kappaB nuclear translocation and transcriptional up-regulation of a variety of cell growth-promoting factors; and apoptotic cell death in susceptible tumor cell populations. In vitro studies indicate that this agent exhibits a favorable cytotoxicity profile toward normal human epithelial cells, bone marrow progenitors, and bone marrow-derived stromal cells relative to the proteasome inhibitor bortezomib. The intracellular protein IkappaBalpha functions as a primary inhibitor of the proinflammatory transcription factor NF-kappaB. Synonyms: CEP 7055; CEP7055; 3-(9-isopropoxymethyl-5-oxo-6,7,12,13-tetrahydro-5H-indeno[2,1-a]pyrrolo[4,3-c]carbazol-12-yl)propyl 2-dimethylaminoacetate. CAS No. 402857-58-3. Molecular formula: C32H35N3O4. Mole weight: 525.65. | |
| CEP-9722 | CEP-9722 is a small-molecule prodrug of CEP-8983, a novel 4-methoxy-carbazole inhibitor of the nuclear enzymes poly(ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration and conversion from CEP-9722, CEP-8983 selectively binds to PARP 1 and 2, preventing repair of damaged DNA via base excision repair (BER). This agent enhances the accumulation of DNA strand breaks and promotes genomic instability and apoptosis. CEP-8983 may potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and can be activated by single strand breaks in DNA. Synonyms: CEP 9722; CEP9722; 11-methoxy-2-((4-methylpiperazin-1-yl)methyl)-4,5,6,7-tetrahydro-1H-cyclopenta[a]pyrrolo[3,4-c]carbazole-1,3(2H)-dione. CAS No. 916574-83-9. Molecular formula: C24H26N4O3. Mole weight: 418.49. | |
| Cerebrosides | Synonyms: Cerebroside; Glycosphingosides; Ceramides, glyco-; Cerebrosides, nonhydroxy fatty acid-containing; Glycolipids, cerebrosides; Glycosides, cerebrosides; Glycosylceramides; Nonhydroxy fatty acid-containing cerebrosides; Sphingosines, glycosyl, N-acyl. Grades: 95%. CAS No. 85116-74-1. | |
| Cerebrosides (Brain) | Cerebrosides are glycosphingolipids with either glucose or galactose as a polar head group. Cerebrosides are amphipathic in nature. They comprise the major component of the myelin lipids. Cerebrosides are part of non-neural cells including the epithelial cells associated with skin and the digestive system. Synonyms: Total Cerebrosides (Brain, Porcine). Grades: >99%. CAS No. 383906-25-0. Molecular formula: C48H93NO8. Mole weight: Average: 781.953. | |
| Cerebroside sulfate | Cerebroside sulfate is a remarkable biomedical compound, exhibiting prodigious potential for studying diverse neurological disorders such as Alzheimer's disease, Parkinson's disease and multiple sclerosis. Its distinctive configuration and inherent characteristics render it an alluring contender for novel drug development aiming at the central nervous system. Encouraging outcomes from preclinical investigations substantiate its capacity to transform the research landscape of these incapacitating illnesses. Synonyms: Sulfatides; Ceramide-galactoside-3-sulfate; 3-O-sulfo-b-D-C24-galactosylceramide. CAS No. 85496-63-5. Molecular formula: C42H80NNaO11S. Mole weight: 830.14. | |
| cerliponase alfa | Cerliponase alfa, known as Brineura, is an enzyme replacement therapy for Batten disease. In April 2017, Brineura was approved by FDA to slow loss of walking ability in symptomatic children over three years old with late infantile neuronal ceroid lipofuscinosis type 2 (CLN2), tripeptidyl peptidase 1 (TPP1) deficiency. Uses: An enzyme replacement therapy for batten disease. Synonyms: Brineura. CAS No. 151662-36-1. Molecular formula: C2657H4042N734O79S11. Mole weight: ~59000. | |
| Certolizumab | Certolizumab is a monoclonal antibody that targets TNF-&alpha. Certolizumab has been approved for the treatment of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and Crohn's disease. Synonyms: Certolizumab pegol; Cimzia. CAS No. 428863-50-7. | |
| Cevipabulin succinate | Cevipabulin is a Tubulin polymerisation inhibitor. It can bind to tubulin at the vinca site and promote the polymerization of tubulin into microtubules. Cevipabulin can stabilize tubulin and inhibit microtubule disassembly. This leads to cell cycle arrest at the G2/M phase. Phase I clinical trials for the treatment of solid tumor were discontinued. Uses: Solid tumours. Synonyms: TTI237; TTI 237; TTI-237; D06576; D 06576; D-06576; 5-chloro-6-(2,6-difluoro-4-(3-(methylamino)propoxy)phenyl)-N-((1S)-2,2,2-trifluoro-1-methylethyl)(1,2,4)triazolo(1,5-a)pyrimidin-7-amine (1:1), dihydrate. Grades: 98%. CAS No. 852954-81-5. Molecular formula: C18H18ClF5N6O. Mole weight: 618.94. | |
| CFG920 | CFG920 is a Steroid 17-alpha-hydroxylase inhibitor originated by Novartis. It has potential antiandrogen and antineoplastic activities. It may inhibit cell proliferation of androgen-dependent tumor cells. In Jan 2013, Phase-I clinical trials in Prostate cancer in Spain was on-going, but now clinical trials for Prostate cancer is discontinued. Uses: Prostate cancer. Synonyms: CFG920; CFG 920; CFG-920; 1-(2-chloropyridin-4-yl)-3-(4-methylpyridin-3-yl)imidazolidin-2-one. Grades: 98%. CAS No. 1260006-20-9. Molecular formula: C14H13ClN4O. Mole weight: 288.73. | |
| CFM 4 | CFM 4 is a CARP-1 mimetic compound that inhibits CARP-1 binding to APC-2. It causes apoptosis and inhibition of cell growth in cancer cells. Synonyms: CFM-4; CFM 4; CFM4; 1-[(2-Chlorophenyl)methyl]-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one. Grades: ≥99% by HPLC. CAS No. 331458-02-7. Molecular formula: C22H16ClN3OS. Mole weight: 405.9. | |
| CG200745 | CG200745 is a novel hydroxamate-based pan-histone deacetylase inhibitor (HDACI). Like other inhibitors, CG200745 has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. CG200745 inhibited deacetylation of histone H3 and tubulin as much as vorinostat and belinostat did. CG200745 also inhibited growth of prostate cancer cells, increased sub-G1 population, and activated caspase-9, -3 and -8 in LNCaP, DU145 and PC3 cells. These results indicate that CG200745 induces apoptosis. The preclinical results show that combination treatment with docetaxel and new HDACI, CG200745, potentiated anti-tumor effect in hormone-refractory prostate cancer (HRPC) cells via activation of apoptosis. Synonyms: Ivaltinostat; CG-200745; CG-2; (E)-N1-(3-(dimethylamino)propyl)-N8-hydroxy-2-((naphthalen-1-yloxy)methyl)oct-2-enediamide. CAS No. 936221-33-9. Molecular formula: C24H33N3O4. Mole weight: 427.55. | |
| CGC-11047 | CGC-11047 is a second generation polyamine analogue, synthesized through the restriction of molecular conformations of parent polyamine compounds, with potential antineoplastic activity. Polyamine analogue PG11047 may displace endogenous polyamines from DNA binding sites, thereby interfering with cell cycle processes dependent upon polyamine binding and function, and resulting in cell-cycle arrest, induction of apoptosis, depletion of polyamines, and interference with gene and ligand-receptor activities involved with cell growth. This agent may exhibit decreased toxicity and enhanced cytotoxicity profiles compared to first-generation polyamine compounds. In tumor cells, there is an increase dependence on polyamines as well as a dysregulated polyamine metabolic pathway resulting in abnormal or sustained tumor growth. Synonyms: CGC 11047; CGC11047; SL 11047; SL 47; SL47. CAS No. 206991-64-2. Molecular formula: C14H36Cl4N4. Mole weight: 402.27. | |
| CGI560 | CGI560 is a potent BTK inhibitor with IC50 = 400 nM for BTK. Synonyms: CGI-560; CGI 560; 4-(tert-Butyl)-N-(3-(8-(phenylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)benzamide. CAS No. 845269-74-1. Molecular formula: C29H27N5O. Mole weight: 461.57. | |
| CGK733 | CGK733, a thiourea-containing compound, was originally identified as a specific inhibitor of ATR and ATM kinases (IC50 = ~ 200 nM). In prematurely senescent breast, lung, and colon cancer cells CGK733 reportedly suppresses ATM-mediated p21 expression required for survival, resulting in cell death. Synonyms: CGK733; CGK-733; CGK 733. CAS No. 905973-89-9. Molecular formula: C23H18Cl3FN4O3S. Mole weight: 555.84. | |
| Cgp-11130 | Cgp-11130 is a GABAB receptor agonist which was never marketed. It is selective for the GABAB receptor over the GABAA receptor (IC50 = 1.70 μM and > 100 μM, respectively). Synonyms: Cgp 11130; Cgp11130; β-(Aminomethyl)-4-fluorobenzenepropanoic acid. Grades: 98%. CAS No. 52237-19-1. Molecular formula: C10H12FNO2. Mole weight: 197.21. | |
| Cgp-11952 | Cas No. 64078-09-7. | |
| Cgp 45688 | Cgp 45688 is an non-steroidal aromatase inhibitor originated byNovartis. It has anti-tumor effects, but no development for treatment of cancer was reported. Uses: Cancer. Synonyms: Cgp 45688; Cgp45688; Cgp-45688. 4,4'-(2H-tetrazol-2-ylmethylene)bis-Benzonitrile. Grades: 98%. CAS No. 134520-88-0. Molecular formula: C16H10N6. Mole weight: 286.30. | |
| Cgp 47645 | Cgp 47645 is non-steroidal aromatase inhibitor with anti-tumor and endocrine effects. It is orally active. Uses: Anti-tumor. Synonyms: Cgp 47645; Cgp47645; Cgp-47645; Leflutrozole; UNII-RCX0IE6EJZ;4,4'-(fluoro-1H-1,2,4-triazol-1-ylmethylene)bis-Benzonitrile. Grades: 98%. CAS No. 143030-47-1. Molecular formula: C17H10FN5. Mole weight: 303.30. | |
| CGP52421 | Cas No. 179237-49-1. | |
| Cgp 6809 | Cgp 6809 is a new methylnitrosoureido-sugar derivative. It is active against a broad spectrum of transplantable tumours in mice and rats. But Phase I clinical trials for the treatment of solid tumor were discontinued. Uses: Cancer. Synonyms: Cgp 6809; Cgp6809; Cgp-6809; ethyl-6-deoxy-3,5-di-O-methyl-6-(3-methyl-3-nitrosoureido)glucofuranoside. Grades: 98%. CAS No. 84069-38-5. Molecular formula: C12H23N3O7. Mole weight: 321.33. | |
| CGP 77675 | CGP 77675 is a potent Src kinase inhibitor. It can be used to maintain mouse embryonic stem cell (mESC) in combination with CHIR99021. Uses: Protein kinase inhibitors. Synonyms: CGP-77675; 1-(4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenethyl)piperidin-4-ol. Grades: >98%. CAS No. 234772-64-6. Molecular formula: C26H29N5O2. Mole weight: 443.55. | |
| Cgp-8065 | Cgp-8065 is a filaricidal compound and a dithiocarbamate-derivative of amoscanate. Synonyms: Cgp 8065; Cgp8065; N-(4-(4'-Nitroanilino)phenyl) S-(beta-carboxyethyl)dithiocarbamate. Grades: 98%. CAS No. 62939-04-2. Molecular formula: C16H15N3O4S2. Mole weight: 377.43. | |
| CH100 | CH100 is a Chinese herbal medicine. It is previously used in the treatment of human hepatitis C. Uses: Ch100 is used in the treatment of human hepatitis c. Synonyms: CH 100; CH-100; 2-Propanamine, N-(1-methylethyl)-, (4-chlorophenoxy)acetate; Acetic acid, (4-chlorophenoxy)-, compd. with N-(1-methylethyl)-2-propanamine (1:1). Grades: 98%. CAS No. 51346-20-4. Molecular formula: C14H22ClNO3. Mole weight: 287.78. | |
| CH-102 | CH-102 is an isoquinoline derivative. It could inhibit platelet aggregation. Uses: Ch-102 could inhibit platelet aggregation. Synonyms: CH 102; CH102; (3z)-3-imino-8,9-dimethoxy-5,6-dihydro[1,3]thiazolo[4,3-a]isoquinoline-1-carbonitrile; 5,6-Dihydro-3-imino-8,9-dimethoxythiazolo[4,3-a]isoquinoline-1-carbonitrile. Grades: 98%. CAS No. 55393-37-8. Molecular formula: C14H13N3O2S. Mole weight: 287.34. | |
| CH-200 | CH-200 is used as a new antiarrhythmic drug. It suppressed arrhythmia more effectively than did procainamide and lidocaine in beagle dogs. Uses: Ch-200 is used as a new antiarrhythmic drug. Synonyms: CH200; CH 200; 5-Phenacylthieno(3,2-c)pyridinium chloride; 5-(2-Oxo-2-phenylethyl)thieno(3,2-c)pyridinium chloride. Grades: 98%. CAS No. 64955-45-9. Molecular formula: C15H12ClNOS. Mole weight: 289.78. | |
| CH-223191 | CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist with IC50 of 30 nM.CH223191 can prevent 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental pollutant with many toxic effects, including endocrine disruption, reproductive dysfunction, immunotoxicity, liver damage, and cancer. CH223191 potently inhibits TCDD-induced AhR-dependent transcription. In addition, CH-223191 blocked the binding of TCDD to AhR and inhibited TCDD-mediated nuclear translocation and DNA binding of AhR. These inhibitory effects of CH-223191 prevented the expression of cytochrome P450 enzymes, target genes of the AhR. CH-223191, may be a useful agent for the study of AhR-mediated signal transduction and the prevention of TCDD-associated pathology. Synonyms: CH223191; CH-223191; CH 223191. Grades: >98%. CAS No. 301326-22-7. Molecular formula: C19H19N5O. Mole weight: 333.39. | |
| CH-401Na | CH-401Na is a bio-active chemical compound. Synonyms: CH 401Na; CH-401-Na; CH401-Na; 1-(2-Hydroxy-4-(3-sulfopropyloxy)phenyl)-3-(3-hydroxy-4-methoxyphenyl)-1-propanone sodium salt. Grades: 98%. CAS No. 59881-19-5. Molecular formula: C19H21NaO8S. Mole weight: 432.42. | |
| CH5015765 | CH5015765 is a novel potent and selective HSP90 inhibitor. CH5015765, which showed high affinity for Hsp90 and antitumor activity in human cancer xenograft mouse models. Synonyms: CH-5015765; CH 5015765; 4-(5-chloro-1,3-dihydrobenzo[de]isochromen-6-yl)-6-(methylthio)-1,3,5-triazin-2-amine. Grades: 98%. CAS No. 959766-47-3. Molecular formula: C16H13ClN4OS. Mole weight: 344.82. | |
| CH5164840 | CH5164840 is a potent and selective HSP90 inhibitor. CH5164840 showed remarkable antitumor activity against NSCLC cell lines and xenograft models. CH5164840 has potent antitumor activity and is highly effective in combination with erlotinib against NSCLC tumors with EGFR overexpression and mutations. Synonyms: CH5164840; CH-5164840; CH 5164840. Grades: 98%. CAS No. 1052645-73-4. Molecular formula: C19H23N5O2S. Mole weight: 385.49. | |
| CHARANTIN(NEW)(P) | Charantin is a potent natural compound derived from bitter melon primarily used in the biomedical industry for the research of diabetes mellitus and related conditions. Synonyms: CHARANTIN(NEW)(P); Monordica Charantia. Grades: 98%. CAS No. 57126-62-2. Molecular formula: A - C35H58O6; B - C35H60O6. | |
| Charantoside | | |
| CHF 5074 | CHF 5074 is a novel γ-secretase modulator. It reduces Aβ42 and Aβ40 secretion with IC50 values of 3.6 and 18.4 μM respectively. It protects SH-SY5Y human neuronal-like cells from amyloidbeta 25-35 and tumor necrosis factor related apoptosis inducing ligand toxicity in vitro. Uses: Chf5074 induces microglia alternative activation in plaque-free tg2576 mice and primary glial cultures exposed to beta-amyloid. it restores visual memory ability and pre-synaptic cortical acetylcholine release in pre-plaque tg2576 mice. it is a non-steroidal anti-inflammatory derivative holding disease-modifying potential for the treatment of alzheimer's disease. it significantly reduces the apoptosis in hippocampal neurons exposed to ogd, as revealed by cleaved-caspase-3 immunoreactivity and tunel staining. Synonyms: CHF-5074; Itanapraced; 1-[4-(3,4-dichlorophenyl)-3-fluorophenyl]cyclopropane-1-carboxylic acid. Grades: >98%. CAS No. 749269-83-8. Molecular formula: C16H11Cl2FO2. Mole weight: 325.16. | |
| CHF-6366 | CHF-6366 is a dual-acting antagonist of muscarinic acetylcholine receptor M3 and beta-2 adrenergic receptor (MABA) being developed as inhalable bronchodilator. Stusies in vivo and in vitro showed that CHF-6366 is a promising drug for the treatment of chronic obstructive pulmonary disease with long-acting, low toxic and potent activity. Uses: The potential treatment of chronic obstructive pulmonary disease. Synonyms: CHF 6366; CHF6366. CAS No. 1615208-41-7. Molecular formula: C42H48N6O8. Mole weight: 764.87. | |
| CHIR-98014 | CHIR-98014 is a GSK3 inhibitor with IC50 values of 0.65 nM and 0.58 nM for GSK-3α and GSK-3β respectively. It can activate Wnt/β-catenin pathway in mouse embryonic stem cells (mESCs). Synonyms: CHIR98014; 6-N-[2-[[4-(2,4-dichlorophenyl)-5-imidazol-1-ylpyrimidin-2-yl]amino]ethyl]-3-nitropyridine-2,6-diamine. Grades: >98%. CAS No. 252935-94-7. Molecular formula: C20H17Cl2N9O2. Mole weight: 486.31. | |
| CHIR-98024 | CHIR98014 is a reversible, cell-permeable inhibitor of GSK3α and GSK3β (IC50 = 0.65 and 0.58 nM, respectively). It is inactive against a series of other serine/threonine or tyrosine kinases. Synonyms: CHIR98014; CHIR-98014; CHIR 98014; CT 98024; CT-98024; CT98024. Grades: 98%. CAS No. 556813-39-9. Molecular formula: C20H17Cl2N9O2. Mole weight: 486.31. | |
| Chloramphenicol 1-O-b-D-galactopyranoside | Chloramphenicol 1-O-b-D-galactopyranoside is an esteemed compound, serving as a formidable warrior against malevolent bacterial infections. Functioning as a procompound, it elegantly transforms into Chloramphenicol is an unparalleled broad-spectrum antibiotic that effectively obstructs bacterial protein development. This exquisitely tailored derivative demonstrates remarkable enhancements in terms of solubility, stability and bioavailability. Synonyms: D-(-)-threo-2-Dichloroacetamido-3-b-D-galactopyranosyl-1-(p-nitrophenyl)-1,3-propaneodiol). CAS No. 191476-32-1. Molecular formula: C17H22N2O10Cl2. Mole weight: 485.27. | |
| CHMFL-BMX-078 | CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor that exhibits an IC50 of 11 nM against BMX kinase and exhibits great selectivity over kinases such as BTK, JAK3, EGFR, and MAP2K7 that bore a structurally identical cysteine residue in BMX kinase. Uses: Protein kinase inhibitors. Synonyms: CHMFL-BMX-078; CHMFL-BMX 078;CHMFL BMX 078; CHMFLBMX078; 4- (methylamino) -2-[4-methyl-3- (prop-2-enoylamino) anilino]-N-[2-methyl-5-[ (3, 4, 5-trimethoxybenzoyl) amino]phenyl]pyrimidine-5-carboxamide; 2-((3-acrylamido-4-methylphenyl)amino)-N-(2-methyl-5-(3,4,5-trimethoxybenzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide. CAS No. 1808288-51-8. Molecular formula: C33H35N7O6. Mole weight: 625.67. | |
| Cholan-24-oic acid, 3,7,12,23-tetrahydroxy-, (3α, 5β, 7α, 12α, 23S)- | Cas No. 181139-68-4. Molecular formula: C24H40O6. Mole weight: 424.57. | |
| Cholesterol β-D-Glucoside | Cholesterol β-D-glucoside is a derivative of cholesterol that contains β-D-glucose. It is formed from cholesterol and glucosylceramide by β-glucosidase 1. It is a lipid mediator in heat stress responses in animals, showing anti-ulcer effect. It activates heat shock transcription factor 1 (Hsf1) in response to heat shock, which increases the expression of heat shock protein 70 (Hsp70) in TIG-3 human fetal lung fibroblasts when used at a concentration of 10 μM. Synonyms: β-ChlGlc; Cholesteryl Glucoside; GluChol; Glucosyl Cholesterol; β-D-glucosyl cholesterol. Grades: ≥95%. CAS No. 7073-61-2. Molecular formula: C33H56O6. Mole weight: 548.79. | |
| CHR-3996 | CHR-3996 is an orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor CHR-3996 inhibits HDAC, resulting in an accumulation of highly acetylated histones, the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes; these events may result in the inhibition of tumor cell division and the induction of tumor cell apoptosis. This agent may upregulate HSP70 and downregulate anti-apoptotic Bcl-2 proteins more substantially than some first-generation HDAC inhibitors. HDACs, upregulated in many tumor cell types, are a family of metalloenzymes responsible for the deacetylation of chromatin histone proteins. Synonyms: CHR3996; CHR 3996; VRx-3996; VRx3996; VRx 3996; Nanatinostat; Tractinostat. CAS No. 1235859-13-8. Molecular formula: C21H20FN5O2. Mole weight: 393.42. | |
| Chrysophanol 8-O-β-D-glucoside | Cas No. 13241-28-6. | |
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