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Citreamicin γ
It is produced by the strain of Micromonospora citrea. Citreamicin γ has anti-gram-positive aerobic and anaerobic bacterial activities. Synonyms: LL E19085 gamma; Citreamicin gamma; 1-((Acetyloxy)methyl)-3a,4-dihydro-16-hydroxy-11,12-dimethoxy-1,3a-dimethyl-(1)benzopyrano(2',3':6,7)naphth(2,1-g)oxazolo(3,2-b)isoquinoline-2,8,14,15,17(1H)-pentone. CAS No. 128999-31-5. Molecular formula: C33H25NO12. Mole weight: 627.55.
Citreoindole
Citreoindole is a diketopiperazine metabolite isolated from a hybrid cell fusion of two strains of P. citreovirde that is cytotoxic in vitro against HeLa cells at 8.4 μM. Grade: >95% by HPLC. CAS No. 138655-14-8. Molecular formula: C29H28N4O4. Mole weight: 496.56.
Citreomontanin
A metabolite of penicillium pedemontanum. Synonyms: all-E-citreomontanin; Citreomontanine; 2H-Pyran-2-one, 4-methoxy-5-methyl-6-(7,9,11-trimethyl-1,3,5,7,9,11-tridecahexaenyl)-, (all-E)-; 4-methoxy-5-methyl-6-((1E,3E,5E,7E,9E,11E)-7,9,11-trimethyltrideca-1,3,5,7,9,11-hexaen-1-yl)-2H-pyran-2-one. Grade: 95%. CAS No. 74474-66-1. Molecular formula: C23H28O3. Mole weight: 352.47.
Citreoviridin
The dominant analogue of a family of tetraene mycotoxins with potent neurotoxic effects, produced by several species of aspergillus and penicillium. It inhibits mitochondrial ATPase and is a causative agent of cardiac beriberi. Synonyms: Citreoviridin A; Citreoviridine; Citreoviridine A; [2S-[2α(1E,3E,5E,7E),3β,4α,5α]]-4-Methoxy-5-methyl-6-[7-methyl-8-(tetrahydro-3,4-dihydroxy-2,4,5-trimethyl-2-furanyl)-1,3,5,7-octatetraenyl]-2H-pyran-2-one; 2,5-Anhydro-1,6-dideoxy-2-C-[(1E,3E,5E,7E)-8-(4-methoxy-5-methyl-2-oxo-2H-pyran-6-yl)-2-methyl-1,3,5,7-octatetraenyl]-4-C-methyl-D-Iditol. Grade: >97% by HPLC. CAS No. 25425-12-1. Molecular formula: C23H30O6. Mole weight: 402.48.
Citrinin
It is produced by the strain of Penicillum citrinum. Citrinin has the ability of anti-gram positive bacteria, negative bacteria (weak) and mycobacterium (10-100 μg/mL), and can inhibit vaginal trichomonas when diluted with 1:25600 ratio. It can also induce the differentiation of mouse leukemia cells. Synonyms: (-)-Citrinin; UNII-3S697X6SNZ. CAS No. 518-75-2. Molecular formula: C13H14O5. Mole weight: 250.25.
Citrinin hydrate
It is produced by the strain of Penicillum sp. AB 2089ZZD-62 (NRRL 22559). Citrinin hydrate is a human rhinovirus 3C protease inhibitor with the IC50 of 1.0 mmol/L. Synonyms: (1s,3r,4s)-1,6,8-trihydroxy-3,4,5-trimethyl-3,4-dihydro-1h-isochromene-7-carboxylic acid; 3,4-Dihydro-1,6,8-trihydroxy-3,4,5-trimethyl-1H-2-benzopyran-7-carboxylic acid. CAS No. 157643-56-6. Molecular formula: C13H16O6. Mole weight: 268.26.
Citromycin
Citromycin, an antibiotic, is isolated from the cultures of two strains of Streptomyces. Synonyms: 4H,5H-Pyrano[3,2-c][1]benzopyran-4-one, 8,9-dihydroxy-2-methyl-. Grade: ≥98%. CAS No. 37209-30-6. Molecular formula: C13H10O5. Mole weight: 246.22.
CJ-12371
CJ-12371 is a DNA gyrase inhibitor originally isolated from N 983-46. It was resistant to Gram-positive bacteria, including Staphylococcus, Streptococcus, Enterococcus and Ciprofloxacin, with MIC of 25-100 μg/mL. Synonyms: AC1LAGH1; (4S)-3,4-Dihydro-2H-spiro[naphthalene-1,2'-naphtho[1,8-de][1,3]dioxine]-4,5-diol. Molecular formula: C20H16O4. Mole weight: 320.34.
CJ-12372
CJ-12372 is an inhibitor of DNAgyrase produced by an unidentified fungus N 983-46. It has anti-Gram-positive bacteria, including Staphylococcus, Streptococcus, Enterococcus and Ciprofloxacin (Ciprofloxacin) drug-resistant bacteria activity, with MIC of 25-100 μg/mL. CAS No. 157110-17-3. Molecular formula: C20H16O5. Mole weight: 336.34.
CJ-12373
CJ-12373 is produced by the strain of Penicillum sp. CL22557. It inhibits the superhelix and relaxation mediated by DNA gyrase, not form cracking intermediates, also inhibits the relaxation mediated by eukaryotic topoisomerase II. And it also has anti-Gram-positive bacteria, including Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes and Streptococcus agalactiae, which are sensitive and resistant to ciprofloxacin. Molecular formula: C17H24O6. Mole weight: 324.37.
CJ-12954
It is produced by the strain of Phanerochaete velutina CL6387. CJ-12954 has strong anti-helicobacter pylori activity. Synonyms: (3R)-5,7-Dimethoxy-3-{6-[(2R,5R)-7-methyl-1,6-dioxaspiro[4.4]non-2-yl]hexyl}-2-benzofuran-1(3H)-one. Molecular formula: C24H34O6. Mole weight: 418.52.
CJ-13014
It is produced by the strain of Phanerochaete velutina CL6387. CJ-13014 is stereoisomer with CJ-12954 and it has strong anti-helicobacter pylori activity. Molecular formula: C24H34O6. Mole weight: 418.52.
CJ-13136
CJ-13136 is originally isolated from Pseudonocardia sp. CL38489. It has highly selective anti-helicobacter pylori activity. Synonyms: 3-Methyl-2-((2E)-3,7-dimethyl-2,6-octenyl)quinoline-4(1H)-one; SCHEMBL14519803. Molecular formula: C20H25NO. Mole weight: 295.42.
CJ-13981
It is originally isolated from CL15036. CJ-13981 inhibited SSASE in rat liver and human liver with IC50 of 4.4 μmol/L and 2.8 μmol/L respectively. Molecular formula: C18H30O6. Mole weight: 342.43.
CJ 14258
CJ 14258, produced by the strain of Hericium ramosum CL 24240, is a selective binding inhibitor of κ-opioid receptor with IC50 of 32 μmol/L. Synonyms: Antibiotic CJ 14258; (12S,15S)-15-O-Demethyl-10,29-dideoxy-11,12-dihydro-striatin C. Molecular formula: C25H38O6. Mole weight: 434.56.
CJ-14877
It is originally isolated from Marasmiellus sp. CL21624. CJ-14877 inhibited human blood interleukin-1β (IL-1β) production induced by lipoglycan (LPS) with an IC50 of 0.1 μmol/L. Synonyms: 2-Pyridinecarboxylic acid, 5-[(1S,2S)-1,2-dihydroxypropyl]-, methyl ester. Molecular formula: C10H13NO4. Mole weight: 211.21.
CJ-14897
It is originally isolated from Marasmiellus sp. CL21624. CJ-14897 inhibited human blood interleukin-1β (IL-1β) production induced by lipoglycan (LPS) with an IC50 of 0.059 μmol/L. Synonyms: (+)-CJ-14897; 2-Pyridinecarboxylic acid, 5-((1S,2S)-2-(acetyloxy)-1-hydroxypropyl)-, methyl ester; UNII-10M04QP59K. CAS No. 377755-95-8. Molecular formula: C12H15NO5. Mole weight: 253.25.
CJ-15183
CJ-15183 is originally isolated from Aspergillus aculeatus CL38916. It has strong inhibitory activity against rat liver, human liver and Candida albicans SSase, and has antifungal activity against filamentous fungi and yeast-like fungi. Molecular formula: C28H38O13. Mole weight: 582.59.
CJ-15208
CJ-15208 is produced by the strain of Ctenomyces serratus. It selectively inhibits κ-opioid receptor binding with an IC50 of 47 nmol/L. Synonyms: (3S,6S,9S,14aR)-6-((1H-indol-3-yl)methyl)-3,9-dibenzyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone; c[L-Phe-D-pro-L-Phe-L-trp]. CAS No. 210236-47-8. Molecular formula: C34H35N5O4. Mole weight: 577.67.
CJ 15544
CJ 15544 is a potent κ-opioid receptor antagonist from a fungus, Hericium ramosum CL 24240. Synonyms: Antibiotic CJ 15544. Molecular formula: C25H34O6. Mole weight: 430.53.
CJ-15696
CJ-15696 is a furopyridine antibiotic produced by the strain of Cladobotryum varium CL12284. It has moderate activity against gram-positive bacteria, including drug-resistant bacteria. Molecular formula: C19H19NO3. Mole weight: 309.36.
CJ-15801
It is originally isolated from Seimatosporium sp. CL28611. CJ-15801 has only anti-MRSA activity with MIC of 6.25-50 μg/mL. Synonyms: CJ-15,801; BDBM50285609; 3-[[(R)-2,4-Dihydroxy-3,3-dimethylbutanoyl]amino]acrylic acid. Molecular formula: C9H15NO5. Mole weight: 217.22.
CJ-16169
CJ-16169 is a furopyridine antibiotic produced by the strain of Cladobotryum varium CL12284. It has weak activity against gram-positive bacteria. Molecular formula: C19H21NO3. Mole weight: 311.37.
CJ-16170
CJ-16170 is a furopyridine antibiotic produced by the strain of Cladobotryum varium CL12284. It has weak activity against gram-positive bacteria. Molecular formula: C19H21NO3. Mole weight: 311.37.
CJ-16173
CJ-16173 is a furopyridine antibiotic produced by the strain of Cladobotryum varium CL12284. It has weak activity against gram-positive bacteria. Molecular formula: C19H19NO4. Mole weight: 325.36.
CJ-16367
It is originally isolated from CL39457. CJ-16367 is mainly resistant to Gram-positive bacteria, including multi-drug resistant strains, but its activity is weak. Molecular formula: C23H31NO5. Mole weight: 401.49.
CJ-17572
It is produced by the strain of Pezicula sp. CJ-11877. CJ-17572 has anti-MRSA and Enterococcus faecalis activity with MIC of 10-20 μg/mL. Synonyms: 3-[hydroxy(1,2,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)methylidene]-5-(1-hydroxyethyl)-1-methylpyrrolidine-2,4-dione. Molecular formula: C21H31NO4. Mole weight: 361.47.
CJ-17665
CJ-17665 is produced by the strain of Aspergillus ochraceus. It inhibits growth of multi-drug resistant MRSA, Streptococcus pyogenes and Enterococcus faecalis with MIC of 12.5, 12.5 and 25 μg/mL, respectively. Molecular formula: C26H33N3O4. Mole weight: 451.56.
CJ-19784
CJ-19784 is an antibiotic which is mainly resistant to Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. It is produced by the strain of Acanthostigmella sp. CL-12082. Synonyms: 4H-1-Benzopyran-4-one,2-(3-bromo-2-hydroxyphenyl)-5-hydroxy-3,7,8-trimethoxy. CAS No. 399509-71-8. Molecular formula: C18H15BrO7. Mole weight: 423.21.
CJ-21058
CJ-21058 is a SecA inhibitor originally isolated from CL47745. It shows antiprotozoal effects (IC50 = 7 μM, T. brucei) and inhibits post-translational protein transport into the endoplasmic reticulum. It shows antibacterial and antifungal effects in vivo. Synonyms: CHEMBL565009; (5R,Z)-3-(Hydroxy((1R,2S,6S,8aS)-1,3,6-trimethyl-2-((E)-prop-1-en-1-yl)-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl)methylene)-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione. Grade: >98% by HPLC. CAS No. 405072-57-3. Molecular formula: C23H33NO4. Mole weight: 387.51.
CJ-21164
It is produced by the strain of Chloridium sp. CL48903. The IC50 of CJ-21164 inhibiting G6Pase in rat liver microsomes was 1.6 μmol/L. Synonyms: CHEMBL3218304. Molecular formula: C38H37ClO14. Mole weight: 753.14.
CKD-711
It is produced by the strain of Streptomyces sp. CK-4416. CKD-711 strongly inhibited mammalian α-glucosidase activity, but weakly inhibited mammalian α-amylase from microorganism and mammal, which was similar to acarbose in vivo and in vitro. Synonyms: 4-Deoxy-4-{[(1R,2R,3S,4R,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)-7-oxabicyclo[4.1.0]hept-2-yl]amino}-α-D-glucopyranosyl-(1->4)-α-D-glucopyranosyl-(1->4)-D-glucopyranose. Molecular formula: C25H43NO20. Mole weight: 677.60.
Cladospolide A
It is produced by the strain of Cladosporium sp. FT-0012. Cladospolide A has little antibacterial activity. Synonyms: (-)-Cladospolide A; Oxacyclododec-3-en-2-one, 5,6-dihydroxy-12-methyl-, (3E,5R,6S,12R)-. CAS No. 77663-54-8. Molecular formula: C12H20O4. Mole weight: 228.28.
Cladospolide B
It is produced by the strain of Cladosporium sp. FT-0012. Cladospolide B has little antibacterial activity. Synonyms: 4,5-di-epi-Cladospolide C. CAS No. 96443-55-9. Molecular formula: C12H20O4. Mole weight: 228.28.
Cladospolide D
It is produced by the strain of Cladosporium sp. FT-0012. Cladospolide D has the activity against part of fungi. CAS No. 371229-61-7. Molecular formula: C12H18O4. Mole weight: 226.27.
Cladosporide A
It is produced by the strain of Cladosporium sp. IFM 49189. Cladosporide A inhibits Aspergillus fumigatus with IC50 of 0.5-4.0 μg/mL, but it has no effect on other filamentous fungi. CAS No. 310897-84-8. Molecular formula: C25H40O3. Mole weight: 388.58.
Cladosporide B
It is produced by the strain of Cladosporium sp. IFM 49189. Cladosporide B has slightly stronger anti-aspergillus fumigatus activity than A. CAS No. 376368-81-9. Molecular formula: C25H38O3. Mole weight: 386.57.
Clarithromycin related compound C
An impurity found in the macrolide antibiotic, Clarithromycin. Synonyms: 6-O-Methylerythromycin 9-Oxime; Clarithromycin Impurity C. Grade: >95% by HPLC. CAS No. 103450-87-9. Molecular formula: C38H70N2O13. Mole weight: 762.97.
Clasto-Lactacystin β-lactone
Clasto-Lactacystin β-lactone is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome. Clasto-lactacystin β-lactone was later identified as the active metabolite of lactacystin, resulting from the elimination of cysteine and the formation of a reactive β-lactone. It is 20-fold more potent than Lactacystin. Synonyms: β-Clastolactacystin; Omuralide. Grade: ≥95%. CAS No. 154226-60-5. Molecular formula: C10H15NO4. Mole weight: 213.23.
Clavam-2-carboxylate
It is produced by the strain of Strrptomyces clavuligerus. Clavam-2-carboxylate has the activity against part of fungi. Synonyms: SCHEMBL8589184. CAS No. 212268-81-0. Molecular formula: C6H7NO4. Mole weight: 157.12.
Clavamycin A
Clavamycin A is produced by the strain of Streptomyces hygroscopicus NRRL 15846. It has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase. Synonyms: Serine, 3-(7-oxo-4-oxa-1-azabicyclo(3.2.0)hept-3-yl)-N-(3-(7-oxo-4-oxa-1-azabicyclo(3.2.0)hept-3-yl)seryl)-. CAS No. 103059-93-4. Molecular formula: C16H22N4O9. Mole weight: 414.37.
Clavamycin B
Clavamycin B is produced by the strain of Streptomyces hygroscopicus NRRL 15846. It has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase. Synonyms: CHEBI:81031. Molecular formula: C13H22N4O8. Mole weight: 362.34.
Clavamycin C
Clavamycin C is produced by the strain of Streptomyces hygroscopicus NRRL 15846. It has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase. Synonyms: CHEBI:81032. Molecular formula: C13H22N4O8. Mole weight: 362.34.
Clavariopsin A
It is produced by the strain of Clavariopsis aquatica AJ117363. Clavariopsin A has anti-candida albicans, Aspergillus fumigata and Aspergillus Niger activity, and has little effect on bacteria. Synonyms: Clarvariopsin A; 2-{(4S,7S,10S,13S,16S,22S,25S,28R)-3,6,9,12,15,18,21,24,30-Nonaaza-13,16-bis((1S)-1-methylpropyl)-25-[(4-methoxyphenyl)methyl]-3,9,12,15,21-pentamethyl-27-oxa-2,5,8,11,14,17,20,23,26,29-decaoxo-4,7,22,28-tetrakis(methylethyl)bicyclo[28.4.0]tetratriacont-10-yl}acetic acid. Molecular formula: C59H95N9O14. Mole weight: 1154.43.
Clavariopsin B
It is produced by the strain of Clavariopsis aquatica AJ117363. Clavariopsin B has anti-candida albicans, Aspergillus fumigata and Aspergillus Niger activity, and has little effect on bacteria. Synonyms: 2-{(4S,7S,10S,13S,16S,22S,25S,28R)-3,6,9,12,15,18,21,24,30-Nonaaza-13,16-bis((1S)-1-methylpropyl)-25-[(4-methoxyphenyl)methyl]-9,12,15,21-tetramethyl-27-oxa-2,5,8,11,14,17,20,23,26,29-decaoxo-4,7,22,28-tetrakis(methylethyl)bicyclo[28.4.0]tetratriacont-10-yl}acetic acid. Molecular formula: C58H93N9O14. Mole weight: 1140.41.
Clavicoronic acid
Clavicoronic acid is produced by the strain of Clavicorona pyxidata. It can inhibit the reverse transcriptase activity of myeloblastocytosis virus (AMV) and Moloney mouse leukemia virus (MMuLV). Synonyms: (6-Formyl-2,2,4-trimethyl-2,3,3a,7a-tetrahydro-1H-inden-5-yl)(oxo)acetic acid; 1H-Indene-5-acetic acid, 6-formyl-2,3,3a,7a-tetrahydro-2,2,4-trimethyl-alpha-oxo-, (3aS-cis)-. CAS No. 139748-98-4. Molecular formula: C15H18O4. Mole weight: 262.30.
Clavilactone A
Clavilactone A is produced by the strain of Clitocybe clavipes. It can inhibit the germination of seeds. Molecular formula: C15H16O5. Mole weight: 276.28.
Clavilactone C
Clavilactone C is produced by the strain of Clitocybe clavipes. It can inhibit the germination of seeds. Molecular formula: C16H16O6. Mole weight: 304.29.
Clazamycin A
It is produced by the strain of Streptomyces No. NF990-BF4. Clazamycin A has weak activity against gram-positive bacteria, gram-negative bacteria and L1210 cell. Synonyms: (2S-trans)-2-Chloro-5-inino-2,3-dihydro-1H-pyrrolizin-7alpha(5H)-ol. CAS No. 71806-55-8. Molecular formula: C7H9ClN2O. Mole weight: 172.61.
Clecarmycin A1
It is produced by the strain of Streptomyces sp. DO-114. Clecarmycin A1 has anti-gram-positive bacteria activity with MIC 0.04-0.33μg/mL and has stronger anti-gram-negative bacteria and candida albicans than C. Clecarmycin A1 also showed strong cytotoxicity, with IC50 of 6.58 mg/mL against HeLa S3 cells, which was 10-20 times stronger than adriamycin. Molecular formula: C29H24O11. Mole weight: 548.49.
Clecarmycin C
It is produced by the strain of Streptomyces sp. DO-114. Clecarmycin C has anti-gram-positive bacteria activity with MIC 0.04-0.33μg/mL. It also showed strong cytotoxicity, with IC50 of 11.5 mg/mL against HeLa S3 cells, which was 10-20 times stronger than adriamycin. CAS No. 136427-31-1. Molecular formula: C29H26O11. Mole weight: 550.51.
Cleomycin A2
It is produced by the strain of Streptomyces verticillus NK-68-144. It has anti-mycobacterial and HeLa cell activity. Synonyms: 3S,S-Dimethylmercaptopropylaminocleomycin; Bleomycinamide, 16-de(1-hydroxyethyl)-N1-(3-(dimethylsulfonio)propyl)-16-(1-hydroxycyclopropyl)-. CAS No. 754137-61-6. Molecular formula: C56H84N17O21S3. Mole weight: 1427.56.
Cleomycin B2
It is produced by the strain of Streptomyces vericillus NK68-144. Cleomycin B2 has the same structure as the corresponding bleomycin. Synonyms: Bleomycinamide, N(1)-(4-((aminoiminomethyl)amino)butyl)-16-de(1-hydroxyethyl)-16-(1-hydroxycyclopropyl)-, (16S)-. CAS No. 76741-88-3. Molecular formula: C56H84N20O21S2. Mole weight: 1437.51.
Clerocidin
Clerocidin is produced by the strain of Oidiodendron truncatum HL-972. It has anti-gram-positive and negative bacteria activity and inhibits mouse P-388 leukemia. Synonyms: Antibiotic PR-1350. CAS No. 87501-14-2. Molecular formula: C40H56O10. Mole weight: 696.84.
Clethramycin
It is produced by the strain of Streptomyces hygroscopicus TPA0623. Clethramycin has activities against candida, cryptococcus neoforme and aspergillus fumigatus with MIC of 0.5-8 μg/mL. And it also inhibits the growth of Pollen tubes. Synonyms: CHEBI:65643. Molecular formula: C63H99N3O18S. Mole weight: 1218.53.
Clitidine
Clitidine is produced by the strain of Clitocybe acromelalga. hypertoxic substance. Synonyms: Chrytidine; 4-imino-1-beta-ribofuranosyl-1,4-dihydro-3-pyridinecarboxylic acid. CAS No. 63592-84-7. Molecular formula: C11H14N2O6. Mole weight: 270.24.
Clomocycline
It is produced by the strain of Streptomyces aureofaciens. Clomocycline has anti-gram-positive and negative bacteria activity. Synonyms: Chlormethylenecycline; N'-Methylolo-chlortetracycline; 7-Chloro-N-(hydroxymethyl)tetracycline; Megaclor. Grade: 95%. CAS No. 1181-54-0. Molecular formula: C23H25ClN2O9. Mole weight: 508.91.
Clonostachin
Clonostachin is a peptide amino alcohol produced by Clonostachys sp. F5898. It has the effect of inhibiting platelet aggregation. Molecular formula: C78H134N14O25. Mole weight: 1667.97.
Cochinmicin I
Cochinmicin I is produced by the strain of Microbispora sp. Cochinmicin I has the antagonistic effect of endothelin and it is the most active of all components. CAS No. 143728-97-6. Molecular formula: C46H47N7O12. Mole weight: 889.90.
Cochinmicin II
Cochinmicin II is produced by the strain of Microbispora sp. Cochinmicin II has the antagonistic effect of endothelin. CAS No. 143728-98-7. Molecular formula: C46H46ClN7O12. Mole weight: 924.35.
Cochinmicin III
Cochinmicin III is produced by the strain of Microbispora sp. Cochinmicin III has the antagonistic effect of endothelin. CAS No. 143728-99-8. Molecular formula: C46H46ClN7O12. Mole weight: 924.35.
Cochinmicin IV
Cochinmicin IV is produced by the strain of Microbispora sp. Cochinmicin IV has the antagonistic effect of endothelin. Molecular formula: C46H46ClN7O13. Mole weight: 940.35.
Cochinmicin V
Cochinmicin V is produced by the strain of Microbispora sp. Cochinmicin V has the antagonistic effect of endothelin. CAS No. 146925-27-1. Molecular formula: C46H47N7O12. Mole weight: 889.90.
Cochleamycin A
It is produced by the strain of Streptomyces sp. DT136. Cochleamycin A showed strong inhibitory activity against tumor cells, with IC50 (μg/mL) of P388, HL60, K562, COL0205 and HT29 cells of 1.6, 14.0, 6.2, 16.5 and 19.1, respectively. It also has anti-gram-positive bacteria activity. Molecular formula: C21H26O6. Mole weight: 374.43.
Cochleamycin A2
It is produced by the strain of Streptomyces sp. DT136. Cochleamycin A2 has the activity of inhibiting tumor cells and anti-gram-positive bacteria. Molecular formula: C23H30O6. Mole weight: 402.48.
Cochleamycin B
It is produced by the strain of Streptomyces sp. DT136. Cochleamycin B has the activity of inhibiting tumor cells. Molecular formula: C21H26O5. Mole weight: 358.43.
Cochleamycin B2
It is produced by the strain of Streptomyces sp. DT136. Cochleamycin B has the activity of inhibiting tumor cells. Molecular formula: C23H30O5. Mole weight: 386.48.
Cochlioquinone A
It is produced by the strain of Bipolaris zeicila. Cochlioquinone A inhibited DGAT with IC50 of 5.6 μg/mL. Synonyms: Coclioquinone A; Pyrano[3,2-a]xanthene-8,11-dione,9-[(1S,2R,3S)-2-(acetyloxy)-1,3-dimethylpentyl]-1,2,3,4a,5,6,6a,12,12a,12b-decahydro-12-hydroxy-3-(1-hydroxy-1-methylethyl)-6a,12b-dimethyl-,(3R,4aR,6aR,12S,12aS,12bR)-; Luteoleersin. Grade: >99% by HPLC. CAS No. 32450-25-2. Molecular formula: C30H44O8. Mole weight: 532.66.
Cochlioquinone A1
It is produced by the strain of Bipolaris zeicila. Cochlioquinone A1 inhibited DGAT with IC50 of 6.3 μg/mL. Molecular formula: C33H50O9. Mole weight: 590.74.
Cochlioquinone B
It is the minor component of a bioactive pigment isolated from Bipolaris cynodontis and Cochliobolus miyabeanus. It is an NADH-ubiquinone reductase inhibitor. It is also a phytotoxic agent inhibiting root growth. It is closely related to cochlioquinone A which inhibits diacylglycerol acyltransferase and exhibits anti-angiogenic and nematocidal activity. It is an antagonist of the human chemokine receptor, CCR5, in HIV-1. Synonyms: 20-De(acetyloxy)-11-deoxy-20-oxo-cochlioquinone A; 9-(1,3-Dimethyl-2-oxopentyl)-1,2,3,4aα,5,6,6a,12,12aα,12b-decahydro-3β-(1-hydroxy-1-methylethyl)-6aβ,12bβ-dimethyl-pyrano[3,2-a]xanthene-8,11-dione Stereoisomer; (3R,4aR,6aR,12aR,12bR)-9-[(1S,3S)-1,3-Dimethyl-2-oxopentyl]-1,2,3,4a,5,6,6a,12,12a,12b-decahydro-3-(1-hydroxy-1-methylethyl)-6a,12b-dimethylpyrano[3,2-a]xanthene-8,11-dione. Grade: >99% by HPLC. CAS No. 32450-26-3. Molecular formula: C28H40O6. Mole weight: 472.61.