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Coenzyme A
Coenzyme A is an essential metabolic cofactor synthesized from cysteine, pantothenate, and ATP. Coenzyme A plays important roles in many metabolic pathways, including the tricarboxylic acid cycle, and the synthesis and oxidation of fatty acids. About 4% of cellular enzymes utilize CoA as a substrate. Synonyms: CoASH; Coenzyme A (free acid); Depot-Zeel; Coenzyme ASH; 3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl] dihydrogen diphosphate}. CAS No. 85-61-0. Molecular formula: C21H36N7O16P3S. Mole weight: 767.53.
Colabomycin A
It is produced by the strain of Streptomyces griseoflavus. It has anti-gram-positive bacterial activity similar to Manumycin, and has the activity of inhibiting leukemic cell L1210. IC50 is 3.4 μg/mL. Synonyms: (2E,4E,6E,8E)-N-[(1beta,6beta)-5alpha-Hydroxy-5-[(1E,3E,5E,7E)-9-[(2-hydroxy-5-oxo-1-cyclopentene-1-yl)amino]-9-oxo-1,3,5,7-nonatetrenyl]-2-oxo-7-oxabicyclo[4.1.0]hepta-3-ene-3-yl]-2,4,6,8-decatetrenamide. CAS No. 117778-57-1. Molecular formula: C30H30N2O7. Mole weight: 530.57.
It is produced by the strain of Bacillus polymyxa var. colistinus and Bac. colistinum Koyama 70-B. It has good anti-gram-negative bacterial activity, but has poor effect on Pseudomonas aeruginosa and Proteus aeruginosa. Colistin B is used as an antibiotic in the treatment of infectious diseases resulting from multi-drug resistant (MDR) gram-negative bacteria. Synonyms: Polymyxin E2; Colistin b; 4,10-anhydro[N-(6-methylheptanoyl)-L-2,4-diaminobutanoyl-L-threonyl-L-2,4-diaminobutanoyl-L-2,4-diaminobutanoyl-L-2,4-diaminobutanoyl-D-leucyl-L-leucyl-L-2,4-diaminobutanoyl-L-2,4-diaminobutanoyl-L-threonine]. Grade: ≥ 95%. CAS No. 7239-48-7. Molecular formula: C52H98N16O13. Mole weight: 1155.43.
Collinemycin
It is produced by the strain of Actinosporaangium sp. C236145. It has anti-gram-positive bacteria and tumor activity. Synonyms: 10-epi-Musettamycin; Musettamycin; 1-Naphthacenecarboxylic acid,1,2,3,4,6,11-hexahydro-6,11-dioxo-2-ethyl-2,5,7,10-tetrahydroxy-4-((2,3,6-trideoxy-4-O-(2,6-dideoxy-alpha-L-lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl)oxy)-, methyl ester, (1S-(1-alpha,2-alpha,4-alpha))-; NSC-304416. CAS No. 72598-49-3. Molecular formula: C36H45NO14. Mole weight: 715.74.
Collinin
Collinin is a coumarin isolated from Flindersia maculosa and other species. Collinin induces apoptosis of human Jurkat T cells and is active against drug-resistant strains of Mycobacterium tuberculosis. Grade: >95% by HPLC. CAS No. 34465-83-3. Molecular formula: C20H24O4. Mole weight: 328.41.
Collinomycin
It is produced by the strain of Streptomyces collinus. It has anti-gram-positive bacterial activity and inhibits human immunodeficiency virus-1 (HIV-1) reverse transcriptase activity. Synonyms: alpha-Rubromycin; Rubromycin; Tuoromycin; Methyl 7,8-dihydroxy-6-[2-(8-hydroxy-5,7-dimethoxy-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-yl)ethyl]-1-oxo-1H-2-benzopyran-3-carboxylate. CAS No. 27267-69-2. Molecular formula: C27H20O12. Mole weight: 536.44.
Collinone
It is produced by the strain of Streptomuces coelicolor CH999. It has anti-gram-positive bacterial activity including methicillin-resistant staphylococcus aureus (MRSA) and vancomycin resistant enterococcus (VRE). MIC is 16-32 μg/mL. It has no effect on gram-negative bacteria, fungi and viruses. It is toxic to HeLa, Vero, MT-4 and other tumor cells. CAS No. 343315-22-0. Molecular formula: C27H18O12. Mole weight: 534.42.
Collismycin A
It is produced by the strain of Streptomyces sp. MQ22. It has the inhibitory effect of dexamethasone-glucocorticoid receptor. IC50 is 1.5 X 10-5 mol/L (rat liver cytosol). It has the anti-tumor cell activity, inhibits rat leukemia cell L1210 with IC50 of 0.08 μg/mL. Synonyms: (E)-4-Methoxy-5-(methylthio)-[2,2'-bipyridine]-6-carbaldehyde oxime; (2E)-4-methoxy-3-methylsulfanyl-2-(nitrosomethylidene)-6-pyridin-2-yl-1H-pyridine. Grade: ≥ 95%. CAS No. 158792-24-6. Molecular formula: C13H13N3O2S. Mole weight: 275.33.
Collismycin B
It is produced by the strain of Streptomyces sp. MQ22. It has the inhibitory effect of dexamethasone-glucocorticoid receptor. IC50 is 1.0 X 10-5 mol/L (rat liver cytosol). It has the anti-tumor cell activity, inhibits rat leukemia cell L1210 with IC50 of 0.12 μg/mL. Synonyms: (2Z)-4-methoxy-3-methylsulfanyl-2-(nitrosomethylidene)-6-pyridin-2-yl-1H-pyridine; 4-methoxy-3-methylsulfanyl-2-(nitrosomethylene)-6-(2-pyridyl)-1H-pyridine. CAS No. 158792-25-7. Molecular formula: C13H13N3O2S. Mole weight: 275.33.
Combimicin A2
It is produced by the strain of Micromonospora sp. K-6993, K-6993-Y-41, NRRL 2958-N-6. It's a kanamycin homolog. CAS No. 72300-83-5. Molecular formula: C20H40N4O9. Mole weight: 480.55.
Combimicin B1
It is produced by the strain of Micromonospora sp. K-6993, K-6993-Y-41, NRRL 2958-N-6. It's a kanamycin homolog. CAS No. 72265-93-1. Molecular formula: C21H43N5O8. Mole weight: 493.59.
Combimicin B2
It is produced by the strain of Micromonospora sp. K-6993, K-6993-Y-41, NRRL 2958-N-6. It's a kanamycin homolog. Synonyms: Combimicin B(sub 2); D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-alpha-D-galactopyranosyl-(1-6)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranosyl-(1-4))-2-deoxy-; 4,6-Diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)hexopyranosyl]oxy}-2-hydroxycyclohexyl 2,6-diamino-2,3,4,6-tetradeoxyhexopyranoside. CAS No. 72265-90-8. Molecular formula: C20H41N5O8. Mole weight: 479.57.
Conagenin
It is produced by the strain of Sreptomyces roseosporus M1696-AF3. It is a low molecular immune modulator. Synonyms: (S)-2-((2R,3S,4R)-2,4-dihydroxy-3-methylpentanamido)-3-hydroxy-2-methylpropanoic acid; N-(3,5-Dideoxy-3-methyl-D-xylonoyl)-2-methyl-L-serine; Conagenine. CAS No. 134381-30-9. Molecular formula: C10H19NO6. Mole weight: 249.26.
Concanamycin D
It is produced by the strain of Streptomyces diastatochromogenes. It has antifungal, antiviral, immunosuppressive, cytotoxic and other activities, and is a specific inhibitor of V-type ATPase, which is an important tool for biochemical research. Synonyms: (3E,5Z,13Z,15Z)-18-[4-[4-[(2S,4R,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-2-hydroxy-5-methyl-6-[(E)-prop-1-enyl]oxan-2-yl]-3-hydroxypentan-2-yl]-8,10-dihydroxy-3,17-dimethoxy-5,7,9,11,13-pentamethyl-1-oxacyclooctadeca-3,5,13,15-tetraen-2-one; 4'-O-de(aminocarbonyl)-8-deethyl-8-methyl-Concanamycin A. CAS No. 144450-34-0. Molecular formula: C44H72O13. Mole weight: 809.03.
Concanamycin E
It is produced by the strain of Streptomyces diastatochromogenes. It has antifungal, antiviral, immunosuppressive, cytotoxic and other activities, and is a specific inhibitor of V-type ATPase, which is an important tool for biochemical research. Synonyms: Concanamycin A, 8-deethyl-; [6-[2-[4-[(4E,6E,14E,16Z)-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6,14,16-tetraen-2-yl]-3-hydroxypentan-2-yl]-2-hydroxy-5-methyl-6-[(E)-prop-1-enyl]oxan-4-yl]oxy-4-hydroxy-2-methyloxan-3-yl] carbamate. CAS No. 144450-35-1. Molecular formula: C44H71NO14. Mole weight: 838.03.
Concanamycin F
It is produced by the strain of Streptomyces diastatochromogenes. It has antifungal, antiviral, immunosuppressive, cytotoxic and other activities, and is a specific inhibitor of V-type ATPase, which is an important tool for biochemical research. Synonyms: Concanamycin A, 23-O-de(4-O-(aminocarbonyl)-2,6-dideoxy-beta-D-arabino-hexopyranosyl)-; concanolide A. CAS No. 144539-92-4. Molecular formula: C39H64O10. Mole weight: 692.92.
Concanamycin G
It is produced by the strain of Streptomyces diastatochromogenes. It has antifungal, antiviral, immunosuppressive, cytotoxic and other activities, and is a specific inhibitor of V-type ATPase, which is an important tool for biochemical research. CAS No. 144730-82-5. Molecular formula: C38H60O9. Mole weight: 660.88.
Confluentic acid
It is produced by the strain of lichens Lecidea confluens, Pertusaria tuberculifera and P. globularis. It is also isolated from L. tumida, L. macrocarpa and Herpothallon sanguineum. Synonyms: NSC 249982; Benzoic acid, 2-hydroxy-4-methoxy-6-(2-oxoheptyl)-, 4-carboxy-3-methoxy-5-pentylphenyl ester; 2-Hydroxy-4-methoxy-6-(2-oxoheptyl)benzoic acid 4-carboxy-3-methoxy-5-pentylphenyl ester; 2-Methoxy-4-[2-(2-oxoheptyl)-4-methoxy-6-hydroxybenzoyloxy]-6-pentylbenzoic acid; Confluentinsaeure; Confluentin. Grade: ≥95%. CAS No. 6009-12-7. Molecular formula: C28H36O8. Mole weight: 500.58.
Confumarprotocetraric acid
Confumarprotocetraric acid exists in most species of the genus Bryophyllum. CAS No. 155214-58-7. Molecular formula: C22H18O12. Mole weight: 474.4.
Congrayanic acid
It has been shown to be a constituent of the Australian lichen Gymnoderma melacarpum (Wils.) Yoshim. Synonyms: Benzoic acid, 3-(2-carboxy-5-methoxy-3-methylphenoxy)-2-heptyl-4,6-dihydroxy-; 2-(3'-carboxy-2'-heptyl-4',6'-dihydroxyphenoxy)-4-methoxy-6-methylbenzoic acid. CAS No. 74683-08-2. Molecular formula: C23H28O8. Mole weight: 432.46.
Coniosetin
It is produced by the strain of Coniochaeta ellipsoidea DSM 13856. It has activity against gram-positive bacteria, including clinical separation of multidrug resistant staphylococcus aureus and resistant to erythromycin streptococcus pneumoniae (MIC is 0.3-0.6 μg/mL), S. pyogenes, dung enterococcus and excrement enterococcus (MIC is 1.2-2.5 μg/mL). It has certain effect on yeast such as Candida albicans (MIC is 3.1 μg/mL). It has weak activity against gram-negative bacteria and other fungi. Synonyms: (5S)-5-[(S)-1-Hydroxyethyl]-3-[[1,2,4abeta,5,6,7,8,8aalpha-octahydro-1beta,3,6alpha-trimethyl-2alpha-[(1E,3E)-1,3-pentadienyl]naphthalene-1-yl]hydroxymethylene]pyrrolidine-2,4-dione. Molecular formula: C25H35NO4. Mole weight: 413.55.
Conocandin
It is produced by the strain of Hormococcus conorium. It has strong antifungal activity. Synonyms: 2-Methylidene-10-methyl-trans-3,4-epoxy-9-hexadecenoic acid. CAS No. 61371-61-7. Molecular formula: C18H30O3. Mole weight: 294.43.
Conorlobaridone
It is the depsidone isolated from the lichen Xanthoparmelia xanthosorediata. Synonyms: 3,8-Dihydroxy-1-pentanoyl-6-propyl-dibenzo[b,e][1,4]dioxepin-11-one; Conlorlobaridon; 11H-Dibenzo[b,e][1,4]dioxepin-11-one, 3,8-dihydroxy-1-(1-oxopentyl)-6-propyl-. CAS No. 71521-80-7. Molecular formula: C21H22O6. Mole weight: 370.40.
Conphysodalic acid
Conphysodalic acid is a secondary metabolite of the lichen Hypogymnia physodes. CAS No. 111720-42-4. Molecular formula: C20H18O10. Mole weight: 418.35.
Conprotocetraric acid
Conprotocetraric acid, the β-orcinol depsidone, has been identified in the lichen, Usnea trichodeoides. Synonyms: 6,14-dihydroxy-7,15-bis(hydroxymethyl)-4,12-dimethyl-10-oxo-2,9-dioxatricyclo[9.4.0.0(3,8)]pentadeca-1(11),3(8),4,6,12,14-hexaene-5-carboxylic acid; 3,8-dihydroxy-4,9-bis(hydroxymethyl)-1,6-dimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepine-7-carboxylic acid. Molecular formula: C18H16O9. Mole weight: 376.31.
Constipatic acid, a fatty acid found in several lichen species, has been isolated from Xanthoparmelia constipata, Parmelia xanthosorediata, Heterodermia appendiculata, Lepraria coriensis, Punctelia negata and Rhizoplaca melanophthalma and so on. Synonyms: 2-(14'-hydroxypentadecyl)-4-methyl-5-oxo-2,5-dihydrofuran-3-carboxylic acid. CAS No. 73036-28-9. Molecular formula: C21H36O5. Mole weight: 368.51.
Consuccinprotocetraric acid
Consuccinprotocetraric acid, the β-orcinol depsidone, has been identified in the lichen, Flavoparmelia succinprotocetrarica. Synonyms: 9-(((3-carboxypropanoyl)oxy)methyl)-3,8-dihydroxy-4-(hydroxymethyl)-1,6-dimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepine-7-carboxylic acid. Molecular formula: C22H20O12. Mole weight: 476.39.
Contortin
It was the first intestinal antigen of the sheep parasite Haemonchus contortus and was used to induce significant levels of protection when inoculated in lambs. Synonyms: 1,1'-(2,2'-dihydroxy-4,4',6,6'-tetramethoxy-5,5'-dimethyl-[1,1'-biphenyl]-3,3'-diyl)bis(ethan-1-one); Ethanone, 1,1'-(2,2'-dihydroxy-4,4',6,6'-tetramethoxy-5,5'-dimethyl(1,1'-biphenyl)-3,3'-diyl)bis-. CAS No. 91925-83-6. Molecular formula: C22H26O8. Mole weight: 418.44.
Convirensic acid
Convirensic acid, a β-orcinol depsidone, has been identified in the lichens, Sulcaria virens. Synonyms: 3,9-dihydroxy-10-(hydroxymethyl)-1,4,7-trimethyl-6-oxobenzo[b][1,4]benzodioxepine-2-carboxylic acid. CAS No. 79586-42-8. Molecular formula: C18H16O8. Mole weight: 360.32.
Coprine
It is produced by the strain of Coprinus atramentarius. It can affect the liver to degrade ethanol. Synonyms: N-(1-hydroxycyclopropyl)-L-glutamine; N(5)-(1-Hydroxycyclopropyl)-L-glutamine. CAS No. 58919-61-2. Molecular formula: C8H14N2O4. Mole weight: 202.21.
It is produced by the strain of Corallococcus (Myxococcus) coralloides. It is a bacterial RNA synthase inhibitor, mainly resistant to gram-positive bacteria. Synonyms: methyl ((R,E)-5-(4-hydroxy-3-((R,2E,4E,9Z,12E)-8-hydroxy-2,5,9-trimethyltetradeca-2,4,9,12-tetraenoyl)-2-oxo-2H-pyran-6-yl)hex-1-en-1-yl)carbamate. CAS No. 93195-32-5. Molecular formula: C30H41NO7. Mole weight: 527.65.
Corallopyronin B
It is produced by the strain of Corallococcus (Myxococcus) coralloides. It is a bacterial RNA synthase inhibitor, mainly resistant to gram-positive bacteria. Synonyms: methyl ((R,E)-5-(4-hydroxy-3-((R,2E,4E,9Z,12E)-8-hydroxy-2,5,9-trimethylpentadeca-2,4,9,12-tetraenoyl)-2-oxo-2H-pyran-6-yl)hex-1-en-1-yl)carbamate. CAS No. 93195-33-6. Molecular formula: C31H43NO7. Mole weight: 541.67.
Corallopyronin C
It is produced by the strain of Corallococcus (Myxococcus) coralloides. It is a bacterial RNA synthase inhibitor, mainly resistant to gram-positive bacteria. Synonyms: [(E)-5-(4-Hydroxy-5-{(E)-2-methyl-4-[2-methyl-5-((1Z,4E)-1-methyl-hexa-1,4-dienyl)-tetrahydro-furan-2-yl]-but-3-enoyl}-6-oxo-6H-pyran-2-yl)-hex-1-enyl]-carbamic acid methyl ester; [5-[4-Hydroxy-3-[2-methyl-1-oxo-4-[tetrahydro-2-methyl-5-(1-methyl-1,4-hexadienyl)furan-2-yl]-3-butenyl]-2-oxo-2H-pyran-6-yl]-1-hexenyl]carbamic acid methyl ester. CAS No. 96717-74-7. Molecular formula: C30H41NO7. Mole weight: 527.65.
Coriolin
It is produced by the strain of Coriolus consors. It has anti-gram-positive bacteria, negative bacteria (weak), yeast and vaginal trichomoniasis activities. Coriolin of 5 μg/mL can inhibit the growth of yoshida sarcoma 61.6%. It had no inhibitory effect on Ehrlich ascites carcinoma in animals. Synonyms: (1aS,3S,7aR)-3bβ,4,5,6,6aβ,7-Hexahydro-4β,7α-dihydroxy-3aα,5,5-trimethylspiro[cyclopenta[4,5]pentaleno[1,6a-b]oxirene-3(3aH), 2'-oxiran]-2(1aH)-one; (3S,7aR)-3aα,5,5-Trimethyl-4β,7α-dihydroxy-1aβ,2,3bβ,4,5,6,6aβ,7-octahydrospiro[cyclopenta[4,5]pentaleno[1,6a-b]oxirene-3(3aH), 2'-oxirane-2-one; (-)-Coriolin; Coriolin A. CAS No. 33404-85-2. Molecular formula: C15H20O5. Mole weight: 280.32.
Coriolin B
It is produced by the strain of Coriolus consors. It has anti-gram-positive bacteria, negative bacteria (weak), yeast and vaginal trichomoniasis activities. Coriolin of 5 μg/mL can inhibit the growth of yoshida sarcoma 61.6%. It had no inhibitory effect on Ehrlich ascites carcinoma in animals. Synonyms: (1aR,3S,7aR)-1aβ,2,3bβ,4,5,6,6aβ,7-Octahydro-2α,7α-dihydroxy-4β-octanoyloxy-3aα,5,5-trimethylspiro[cyclopenta[4,5]pentaleno[1,6a-b]oxirene-3(3aH),2'-oxirane]. CAS No. 33400-89-4. Molecular formula: C23H36O6. Mole weight: 408.53.
Coriolin C
It is produced by the strain of Coriolus consors. It has anti-gram-positive bacteria, negative bacteria (weak), yeast and vaginal trichomoniasis activities. Coriolin of 5 μg/mL can inhibit the growth of yoshida sarcoma 61.6%. It had no inhibitory effect on Ehrlich ascites carcinoma in animals. Synonyms: 3b,4,5,6,6a,7-Hexahydro-7-hydroxy-4-(2-hydroxyoctanoyloxy)-3a,5,5-trimethylspiro[cyclopenta[4,5]pentaleno[1,6a-b]oxirene-3(3aH), 2'-oxiran]-2(1aH)-one. CAS No. 33400-90-7. Molecular formula: C23H34O7. Mole weight: 422.51.
Cornexistin
It is produced by the strain of Paecilomyces variotii SANK 21086. It has the activity of removing annual weeds (0.5 kg/he) and has no antibacterial effect. Synonyms: 14-Dihydroxycornestin; (4R,5S,8S,9Z)-9-ethylidene-5,8-dihydroxy-4-propyl-4,5,7,8,9,10-hexahydro-1H-cyclonona[c]furan-1,3,6-trione. CAS No. 123068-35-9. Molecular formula: C16H20O6. Mole weight: 308.33.
Coronatoquinone
Coronatoquinone is a pyranonaphthazarin from the Lichen Pseudocyphellaria coronata. CAS No. 299190-12-8. Molecular formula: C15H12O8. Mole weight: 320.25.
Coronopilin
Coronopilin is a sesquiterpene lactone. Synonyms: 10αH-Ambros-11(13)-en-12-oic acid, 1,6β-dihydroxy-4-oxo-, γ-lactone (8CI). CAS No. 2571-81-5. Molecular formula: C15H20O4. Mole weight: 264.32.
Cororubicin
It is produced by the strain of Micromonospora sp. JY16. It has anti-tumor cell activity. The IC50 of KB cells and N18-RE-105 cells was 4.3 X 10-6 mol/L and 0.84 X 10-6 mol/L, respectively. CAS No. 160605-92-5. Molecular formula: C48H62N2O21. Mole weight: 1003.00.
Cortinarin A
It is produced by the strain of Cortinarius speciosissimus, C. orellanus and C. orellanoides. It is a peptide antibiotic with vasoconstriction and renal toxicity. CAS No. 88025-84-7. Molecular formula: C58H87N13O12S. Mole weight: 1190.45.
Cortinarin B
It is produced by the strain of Cortinarius speciosissimus, C. orellanus and C. orellanoides. It is a peptide antibiotic with vasoconstriction and renal toxicity. CAS No. 89286-74-8. Molecular formula: C57H85N13O12S. Mole weight: 1176.43.
Cortinarin C
It is produced by the strain of Cortinarius speciosissimus, C. orellanus and C. orellanoides. It is a peptide antibiotic. CAS No. 88025-85-8. Molecular formula: C15H17N3O3. Mole weight: 287.31.
Corynecandin
It is produced by the strain of Coryneum modonium AB 2020T-223. It is a glycolipid antibiotic with antifungal activity. The antifungal spectrum and antifungal activity are similar to Papulacandin. Synonyms: D-Glucitol, 1,5-anhydro-1-C-(2,4-dihydroxy-6-(hydroxymethyl)phenyl)-4-O-(6-O-((2E,4Z)-1-oxo-2,4-decadienyl)-beta-D-galactopyranosyl)-, 3-((2E,4E)-7-hydroxy-2,8-dimethyl-2,4-decadienoate)-. CAS No. 199169-60-3. Molecular formula: C41H60O16. Mole weight: 808.90.
Cosmomycin C
It is an anthracycline antibiotic produced by the strain of Streptomyces cyaneus (A-447). It has anti-tumor and gram-positive bacteria activity. It can inhibit the growth of P388 murine lymphocytic leukemia cells. Synonyms: Antibiotic A-447B; (3''S)-3''-Hydroxycytorhodin A; 3B-Hydroxycytorhodin A; A-447B; β-Rhodomycin S2; 5,12-Naphthacenedione, 8-ethyl-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-10-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2S,5S,6S)-tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl]-a-L-lyxo-hexopyranosyl]-3-(dimethylamino)-a-L-lyxo-hexopyranosyl]oxy]-7-[[2,3,6-trideoxy-3-(dimethylamino)-4-O-[(2S,5S,6S)-tetrahydro-6-methyl-5-[[(2S,5S,6S)-tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl]oxy]-2H-pyran-2-yl]-a-L-lyxo-hexopyranosyl]oxy]-,(7R,8R,10S)-. CAS No. 55945-22-7. Molecular formula: C60H88N2O21. Mole weight: 1173.34.
Cosmomycin D
It is an anthracycline antibiotic produced by the strain of Streptomyces cyaneus (A-447). It has anti-tumor activity. It can inhibit the growth of P388 murine lymphocytic leukemia cells. Synonyms: (3''S,3'''''S)-3'',3'''''-Dihydroxycytorhodin A; 1-Deoxyobelmycin D; 3B,3E-Dihydroxycytorhodin A; A-447A; Antibiotic A-447A; 5,12-Naphthacenedione, 8-ethyl-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-7,10-bis((2,3,6-trideoxy-4-O-(2,6-dideoxy-4-O-((2S,5S,6S)-tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)-alpha-L-lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl)oxy)-, (7R,8R,10S)-. CAS No. 95676-81-6. Molecular formula: C60H88N2O22. Mole weight: 1189.34.
Cotylenin F
It is produced by the strain of Cladosporium sp. It has the function of plant growth regulation. CAS No. 58045-03-7. Molecular formula: C33H54O11. Mole weight: 626.77.
Coumamidine γ1
It is produced by the strain of Saccharopolyspora sp. AB 1167L-65. It is a kind of alkaline water-soluble sugar Cinodine antibiotic, which has broad spectrum antibacterial activity and also has effect on pseudomonas aeruginosa. Synonyms: Coumamidine gamma1; Coumamidine gamma(1). CAS No. 121634-35-3. Molecular formula: C33H49N13O13. Mole weight: 835.82.
Coumamidine γ2
It is produced by the strain of Saccharopolyspora sp. AB 1167L-65. It is a kind of alkaline water-soluble sugar Cinodine antibiotic, which has broad spectrum antibacterial activity and also has effect on pseudomonas aeruginosa. Synonyms: Coumamidine gamma2; Coumamidine gamma(2). CAS No. 121634-34-2. Molecular formula: C33H49N13O13. Mole weight: 835.82.
CP-120509
It is produced by the strain of Actinomadura roseorufa 263606. CP-120509 has anti-gram-positive bacteria, spirochete and spirochete activity, and also has a good anti-coccidiosis effect caused by Eimeria acervulina, E. tenella. Molecular formula: C45H76O17. Mole weight: 889.07.
CP-225917
CP-225917 inhibits Ras farnesyl transferase from the mouse brain and Squalene synthase. Molecular formula: C31H38O10. Mole weight: 570.63.
CP-263114
CP-263114 inhibits Ras farnesyl transferase from the mouse brain and Squalene synthase. CAS No. 186700-09-4. Molecular formula: C31H36O9. Mole weight: 552.61.
CP-35587
CP-35587 is resistant to gram-positive cocci, but it has no effect on penicillin-resistant Staphylococcus aureus and is active against gram-negative bacteria. Synonyms: Benzeneacetamide, alpha-amino-N-(3,3-dimethyl-7-oxo-2-(1H-tetrazol-5-yl)-4-thia-1-azabicyclo(3.2.0)hept-6-yl)-4-hydroxy-, (2S-(2alpha,5alpha,6beta))-. CAS No. 57089-17-5. Molecular formula: C16H19N7O3S. Mole weight: 389.43.
CP 412065
It is originally isolated from Hericium ramosum CL 24240. CP 412065 selectively inhibited κ-opioid receptor binding with IC50 > 200 μnmol/L. Synonyms: Antibiotic CP 412065. Molecular formula: C25H34O6. Mole weight: 430.53.
CP-82009
CP-82009 is a polyether antibiotic originally isolated from Actinomadura sp. It shows strong resistance to chicken coccidiosis, and also has anti-gram-positive bacteria and spirochetes activity. Molecular formula: C49H84O17. Mole weight: 945.18.
CP 91243
CP 91243 is a polyether antibiotic originally isolated from Actinomadura roseorufa. It has anti-gram-positive bacteria, spirochete, treponema activity, and it also has the effect on chicken coccidiosis. CAS No. 135179-21-4. Molecular formula: C50H84O18. Mole weight: 973.19.
CP 91244
CP 91244 is a polyether antibiotic originally isolated from Actinomadura roseorufa. It has anti-gram-positive bacteria, spirochete, treponema activity, and it also has the effect on chicken coccidiosis. Synonyms: Semduramicin, 5-O-(tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)-, (5(2S,5S,6R))-. CAS No. 135215-73-5. Molecular formula: C51H86O18. Mole weight: 987.21.
Cremeomycin
It is produced by the strain of Streptomyces cremeus. It has anti-gram-positive bacteria, negative bacteria, fungi (weak) activity, and has the effect of inhibiting the leukemic cell L-1210 (IC50 is 1.5 μg/mL). Synonyms: Antibiotic U-23643. Molecular formula: C8H6N2O4. Mole weight: 194.14.
Cremimycin
It is produced by the strain of Streptomyces sp. MJ635-86F6. It has anti-gram-positive bacteria activity including methicillin-resistant staphylococcus aureus (MRSA), MIC is 0.2-0.39 μg/mL. It showed cytotoxicity to mouse tumor cell lines P388, L1210, IMC, S180, B16 and SS3 in vitro. Synonyms: Cremimycin (antibiotic); Cyclopent(I)azacyclononadecene-7,11,17(8H,12H,19H)-trione,9,10,13,14,15,16,20,20a-octahydro-19-((2,6-dideoxy-3-O-methylhexopyranosyl)oxy)-15,18-dihydroxy-9-hexyl-2-methyl-. CAS No. 182285-29-6. Molecular formula: C35H53NO9. Mole weight: 631.79.
Crinipellin A
It is produced by the strain of Crinipellis stipitaria. It has anti-gram-positive bacteria and Aldrin ascites carcinoma activity. Synonyms: (1R,3R,6S,8R,9S,11R,12R,13R)-8-hydroxy-7a,9a-dimethyl-3-methylidene-7-(propan-2-yl)hexahydro-1aH,5H-pentaleno[6a',1':5,6]pentaleno[1,6a-b]oxirene-2,9(3H,9aH)-dione. CAS No. 97294-60-5. Molecular formula: C20H26O4. Mole weight: 330.42.
Crinipellin B
It is produced by the strain of Crinipellis stipitaria. It has anti-gram-positive bacteria and Aldrin ascites carcinoma activity. Synonyms: (1aS,3aR,4aS,7R,7aR,9R,9aR,9bR)-9-hydroxy-7-isopropyl-7a,9a-dimethyl-3-methyleneoctahydro-3H,8H-pentaleno[6a',1':5,6]pentaleno[1,6a-b]oxirene-2,8(1aH)-dione. CAS No. 97294-61-6. Molecular formula: C20H26O4. Mole weight: 330.42.
Crisamicin A
It is produced by the strain of Micromonospora purpureochromogenes subsp. lalotolerans. It only has activity against gram-positive bacteria. The activity of samicin C is stronger than Crisamicin A. Synonyms: (3aS)-5β,5'β-Dimethyl-10,10'-dihydroxy-3,3',3aβ,3'aβ,5,5',6,6',11,11',11bβ,11'bβ-dodecahydro-8,8'-bi[2H-furo[3,2-b]naphtho[2,3-d]pyran]-2,2',6,6',11,11'-hexaone; (3aS,3'aS,5S,5'S,11bS,11'bS)-3,3',3a,3'a,5,5',11b,11'b-Octahydro-10,10'-dihydroxy-5,5'-dimethyl-8,8'-bi[2H-furo[3,2-b]naphtho[2,3-d]pyran]-2,2',6,6',11,11'-hexone; CRS-A; (8,8'-Bi-2H-furo(3,2-b)naphtho(2,3-d)pyran)-2,2',6,6'11,11'-hexone,3,3',3a,3'a,5,5',11b,11'b-octahydro-10,10'-dihydroxy-5,5'-dimethyl-, (3aS-(3aalpha,5alpha,8(3aR*,5R*,11bR*),11balpha))-. CAS No. 95828-47-0. Molecular formula: C32H22O12. Mole weight: 598.51.
Crisamicin C
It is produced by the strain of Micromonospora purpureochromogenes subsp. lalotolerans. It only has activity against gram-positive bacteria. The activity of samicin C is stronger than Crisamicin A. Synonyms: CRS-C. CAS No. 100630-79-3. Molecular formula: C32H22O13. Mole weight: 614.51.
Cristatic acid
It is produced by the strain of Albaterllus cristatus. It can resist bacillus, tumor and hemolysis. Synonyms: NSC338268; NSC 338268; Cristatic acid-1. CAS No. 80557-13-7. Molecular formula: C23H28O5. Mole weight: 384.46.
CRM-51005
It is a phospholipase C (PLC) inhibitor originally isolated from fungal MT51005. Synonyms: Benzaldehyde, 3-ethyl-2,4-dihydroxy-6-((1E)-1-methyl-1-pentenyl)-; Benzaldehyde, 3-ethyl-2,4-dihydroxy-6-(1-methyl-1-pentenyl)-, (E)-; 3-ethyl-6-[(E)-hex-2-en-2-yl]-2,4-dihydroxybenzaldehyde. CAS No. 203051-01-8. Molecular formula: C15H20O3. Mole weight: 248.32.
CRM646-A
It is originally isolated from Acremonium sp. MT70646. CRM646-A had a strong inhibitory effect on the movement of B16-H10 melanoma cells with IC50 of 15 μmol/L. Synonyms: CRM-646-A; CHEMBL3347523. Molecular formula: C36H50O13. Mole weight: 690.77.
CRM646-B
It is originally isolated from Acremonium sp. MT70646. CRM646-B had a strong inhibitory effect on the movement of B16-H10 melanoma cells with IC50 of 30 μmol/L. Synonyms: CRM-646-B; 4-[(4-Carboxy-3-hydroxy-5-methylphenoxy)carbonyl]-3-hydroxy-5-pentadecylphenyl methyl β-D-glucopyranosiduronate. Molecular formula: C37H52O13. Mole weight: 704.80.