BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Dybowskin-2 | Dybowskin-2 has antibacterial and antifungal activity. The source of Dybowskin-2 is Rana dybowskii. Grades: >97% by HPLC. |  |
| Dybowskin-2CDYa | Dybowskin-2CDYa is an antimicrobial peptide. It has activity against the Gram-positive bacterium S.aureus (MIC=6 μM) and the Gram-negative bacterium E.coli (MIC=3 μM). Dybowskin-2CDYa lacks hemolytic activity against human erythrocytes. Grades: >96% by HPLC. | |
| Dybowskin-2CDYb | Dybowskin-2CDYb is an antimicrobial peptide from Rana dybowskii. | |
| Dybowskin-3 | Dybowskin-3 is active against S. aureus, B. cereus, and S. lactis (MIC 37.5 uM), C. albicans (MIC 50 uM), and cancer cells MCF7 cells and Hela cells (IC50 50 uM). Synonyms: Brevinin-2DYc. | |
| Dybowskin-4 | Dybowskin-4 has antibacterial and antifungal activity. Dybowskin-4 was found in Rana dybowskii. Grades: >96% by HPLC. | |
| Dybowskin-5 | Dybowskin-5 has antibacterial and antifungal activity. Dybowskin-4 was found in Rana dybowskii. Grades: >96% by HPLC. | |
| Dybowskin-6 | Dybowskin-6 has antibacterial and antifungal activity. Dybowskin-4 was found in Rana dybowskii. | |
| DyLight 3.5 CEP | DyLight 3.5 CEP is a fluorescent dye used for oligonucleotide labeling. Synonyms: 1-[3-(4-monomethoxy)propyl]-1'-[3 -[(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite]propyl] -3,3,3-',3'-Tetramethyl-4,5-benzoindolecyanine chloride. Grades: ≥85.0%. CAS No. 916753-57-6. Molecular formula: C66H74N4O4PCl. Mole weight: 1053.74. | |
| DyLight 3 CEP | DyLight 3 CEP is a fluorescent dye used for oligonucleotide labeling. Synonyms: 1-[3-(4-monomethoxytrityloxy)propyl]-1'-[3-[(2-cyanoethyl)-(N,N-diisopropyl)phosphoramidityl]propyl]-3,3,3',3'-tetramethylindocarbocyanine chloride; Cyanine 3 Phosphoramidite. Grades: ≥90%. CAS No. 182873-76-3. Molecular formula: C58H70N4O4PCl. Mole weight: 953.64. | |
| DyLight 5 CEP | DyLight 5 CEP is a fluorescent dye used for oligonucleotide labeling. Synonyms: 1-[3-(4-monomethoxytrityloxy)propyl]-1'-[3-[(2-cyanoethyl)-(N,N-diisopropylphosphoramidityl]propyl]-3,3,3',3'-tetramethylindodicarbocyanine chloride; Cyanine 5 Phosphoramidite. Grades: ≥85.0%. CAS No. 182873-67-2. Molecular formula: C60H72N4O4PCl. Mole weight: 979.68. | |
| DyLight DY547 CEP | DyLight DY547 CEP is a fluorescent dye used for oligonucleotide labeling. Grades: ≥90%. Molecular formula: C38H54IN4O2P. Mole weight: 756.74. | |
| DyLight DY677 CEP | DyLight DY677 CEP is a fluorescent dye used for oligonucleotide labeling. Grades: ≥85%. Molecular formula: C55H67N4O5PS. Mole weight: 927.18. | |
| Dynorphin (1-17) | Dynorphin A is a heptadecapeptide derived from the cleavage of prodynorphin and found widely distributed in the central nervous system. It acts as an endogenous kappa receptor agonist with nanomolar binding affinity. It also activates the human novel opioid receptor-like receptor of ORL1. It is resistant to enzymatic degradation and may have antinociceptive functions. Uses: Neurotransmitter agents. Synonyms: Dynorphin A (swine); Dynorphin A (pig); 1-17-Dynorphin; L-Glutamine, L-tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-L-arginyl-L-arginyl-L-isoleucyl-L-arginyl-L-prolyl-L-lysyl-L-leucyl-L-lysyl-L-tryptophyl-L-α-aspartyl-L-asparaginyl-; Dyn-A17; Dynorphin 17; Dynorphin A; Dynorphin A (1-17); Dynorphin A (human); Dynorphin A (porcine); Dynorphin A (rat); Dynorphin A 1-17; Dynorphin-A (Bos taurus); Porcine dynorphin (1-17); Porcine dynorphin A (1-17); Proteins, Dyn-A17; Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln. Grades: ≥95%. CAS No. 80448-90-4. Molecular formula: C99H155N31O23. Mole weight: 2147.51. | |
| Dynorphin A 1-10 | Dynorphin A 1-10 is an endogenous opioid neuropeptide that binds to the extracellular loop 2 of the κ-opioid receptor. It also blocks the NMDA activation current with IC50 of 42.0 μM. Synonyms: Dynorphin A, porcine, fragment 1-10; H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-OH; L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucyl-L-arginyl-L-arginyl-L-isoleucyl-L-arginyl-L-proline; Dynorphin A (1-10), porcine. Grades: ≥95%. CAS No. 79994-24-4. Molecular formula: C57H91N19O12. Mole weight: 1234.45. | |
| Dynorphin B 1-13 | Dynorphin B is a 13-residue opioid peptide, which is derived from the cleavage of prodynorphin and found widely distributed in the central nervous system. It acts as an opioid peptide and a κ-opioid receptor agonists. It has been implicated in antinociceptive functions. It has also been used to prime cardiogenesis in pluripotent embryonic stem cells. Synonyms: Prodynorphin (226-238) (human); Prodynorphin (228-240) (porcine); Rimorphin; Dynorphin B 1-13; H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr-OH; L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucyl-L-arginyl-L-arginyl-L-glutaminyl-L-phenylalanyl-L-lysyl-L-valyl-L-valyl-L-threonine. Grades: ≥95%. CAS No. 83335-41-5. Molecular formula: C74H115N21O17. Mole weight: 1570.84. | |
| E07LKK | E07LKK has antibacterial activity against S. aureus, E.coli. | |
| E10KKL | E10KKL is a synthetic construct peptide. It has antibacterial activity. | |
| E12LLK | E12LLK is a synthetic construct peptide. It has antibacterial activity. | |
| E14KKL | E14KKL is a synthetic construct peptide. It has antibacterial activity. | |
| E14LKK / H14LKK | E14LKK / H14LKK is a synthetic construct peptide. It has antibacterial activity. | |
| E23GIG magainin 2 | E23GIG magainin 2 is a synthetic construct peptide. It has antibacterial activity. Grades: >98% by HPLC. | |
| E3 ligase Ligand-Linker Conjugates 30 | E3 ligase Ligand-Linker Conjugates 30 incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 30 can be used to design PROTAC MDM2 degrade. Synonyms: 4- ( (2- (2- (2- (2-aminoethoxy) ethoxy) ethoxy) ethyl) amino) -2- (2, 6-dioxopiperidin-3-yl) isoindoline-1, 3-dione; Pomalidomide-PEG3-C2-NH2; SCHEMBL19451340; BCP33441; HY-128716; CS-0099510; Cereblon Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 30. Grades: > 98%. CAS No. 2093416-31-8. Molecular formula: C21H28N4O7. Mole weight: 448.47. | |
| EA-CATH1 | EA-CATH1 has antibacterial activity. EA-CATH1 was found in Equus asinus. It appeared to be stable in serum and displayed no toxicity to human erythrocytes. Grades: >97% by HPLC. | |
| EAFP1 | EAFP1 is produced by Eucommia ulmoides. It has antifungal activity against P.infestans, A.lycopersici, V.dahliae, G.zeae, A.nicotianae, F.moniliforme, F.oxysporum and C.gossypii. Synonyms: Antifungal peptide 1. | |
| EAFP2 | EAFP2 is produced by Eucommia ulmoides. The inhibition activity of EAFP2 can be effective on both chitin-containing and chitin-free fungi. Synonyms: Antifungal peptide 2. | |
| EB 47 | EB 47 is a potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1). Poly(ADP-ribose) polymerases (PARPs) play a major role in cellular survival and maintenance of energy stores after genotoxic insult. Synonyms: 5'-Deoxy-5'-[4-[2-[(2,3-dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine; 4-[1-(6-Amino-9H-purin-9-yl)-1-deoxy-β-D-ribofuranuronoyl]-N-(2,3-dihydro-1-oxo-1H-isoindol-4-yl)-1-piperazineacetamide. CAS No. 366454-36-6. Molecular formula: C24H27N9O6. Mole weight: 537.53. | |
| EB 47-d8 | Isotope labelled EB 47 is a potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1). Poly(ADP-ribose) polymerases (PARPs) play a major role in cellular survival and maintenance of energy stores after genotoxic insult. Synonyms: 5'-Deoxy-5'-[4-[2-[(2,3-dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine-d8; 4-[1-(6-Amino-9H-purin-9-yl)-1-deoxy-β-D-ribofuranuronoyl]-N-(2,3-dihydro-1-oxo-1H-isoindol-4-yl)-1-piperazineacetamide-d8. Molecular formula: C24H19D8N9O6. Mole weight: 545.58. | |
| EcAMP1 | EcAMP1 was shown to perform antifungal activity against several phytopathogenic fungi, with the most pronounced effect against members of the Fusarium genus. | |
| EC-hepcidin3 | EC-hepcidin3, a new four-cysteine hepcidin isoform gene, was cloned from the marine-cultured orange-spotted grouper (Epinephelus coioides). | |
| Echistatin, α1 isoform | Echistatin, α1 isoform is a potent and irreversible αVβ3 integrin antagonist (Ki = 0.27 nM). It exhibits inhibitory activity for bone reabsorption (IC50 = 0.1 nM) and prevents ADP-induced platelet aggregation by inhibiting glycoprotein IIb/IIIa (GpIIb/IIIa, αIIbβ3) receptors (IC50 = 30 nM) in vitro. Synonyms: H-Glu-Cys(1)-Glu-Ser-Gly-Pro-Cys(2)-Cys(3)-Arg-Asn-Cys(1)-Lys-Phe-Leu-Lys-Glu-Gly-Thr-Ile-Cys(4)-Lys-Arg-Ala-Arg-Gly-Asp-Asp-Met-Asp-Asp-Tyr-Cys(2)-Asn-Gly-Lys-Thr-Cys(3)-Asp-Cys(4)-Pro-Arg-Asn-Pro-His-Lys-Gly-Pro-Ala-Thr-OH; L-alpha-glutamyl-L-cysteinyl-L-alpha-glutamyl-L-seryl-glycyl-L-prolyl-L-cysteinyl-L-cysteinyl-L-arginyl-L-asparagyl-L-cysteinyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-alpha-glutamyl-glycyl-L-threonyl-L-isoleucyl-L-cysteinyl-L-lysyl-L-arginyl-L-alanyl-L-arginyl-glycyl-L-alpha-aspartyl-L-alpha-aspartyl-L-methionyl-L-alpha-aspartyl-L-alpha-aspartyl-L-tyrosyl-L-cysteinyl-L-asparagyl-glycyl-L-lysyl-L-threonyl-L-cysteinyl-L-alpha-aspartyl-L-cysteinyl-L-prolyl-L-arginyl-L-asparagyl-L-prolyl-L-histidyl-L-lysyl-glycyl-L-prolyl-L-alanyl-L-threonine (2->11),(7->32),(8->37),(20->39)-tetrakis(disulfide). Grades: >98%. CAS No. 154303-05-6. Molecular formula: C217H341N71O74S9. Mole weight: 5417.05. | |
| EcLTP | EcLTP has antibacterial and antifungal activity. EcLTP was found in Echinochloa crusgalli L. | |
| EC-proHep3 | EC-proHep3 has strong, rapid activity against Staphylococcus aureus and Pseudomonas stutzeri. It was found in Epinephelus coioides. | |
| EDA-ATP | EDA-ATP could be used as a ligand for modification with markers like fluorophores. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Adenosine-5'-triphosphate, Sodium salt. Grades: ≥ 95 % by HPLC. CAS No. 173074-70-9. Molecular formula: C13H18N7Na4O14P3. Mole weight: 681.23. | |
| EDTA-C2-dT-CE Phosphoramidite | EDTA-C2-dT-CE Phosphoramidite, a catalyst for biomedical synthesis, is rich in EDTA, ensuring thorough metal ion chelation. Its enhanced stability and selectivity imply potential applications in disease research, including HIV and cancer. Employed mostly in genome editing, it exhibits profound biomedical value through its performance in the synthesis of trace oligonucleotides. Synonyms: 5'-Dimethoxytrityl-5-[N-ethylenediaminetriethylacetate, monoacetylaminoethyl-3-acrylimido]-2'-deoxyUridine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. Molecular formula: C60H81N8O16P. Mole weight: 1201.32. | |
| Ee-CBP | Ee-CBP is a hevein-type antimicrobial peptide from bark of the spindle tree (Euonymus europaeus L.). | |
| Eflornithine | Eflornithine is a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. Synonyms: Ornithine, 2-(difluoromethyl)-; 2-(Difluoromethyl)ornithine; 2-(Difluoromethyl)-DL-ornithine; DL-2-(Difluoromethyl)ornithine; DL-α-(Difluoromethyl)ornithine; DFMO; DFMO (growth regulator); Difluromethylornithine; Elfornithine; MDL 71782; MDL 71782A; Ornidyl; RFI 71782; RMI 71782; α,δ-Diamino-α-(difluoromethyl)valeric acid; α-(Difluoromethyl)-DL-ornithine; α-(Difluoromethyl)ornithine. Grades: ≥95%. CAS No. 70052-12-9. Molecular formula: C6H12F2N2O2. Mole weight: 182.17. | |
| ELA-14 (human) | ELA-14 (human) is a potent apelin (APJ) receptor agonist (Ki = 0.93 nM) stimulating Gαi1 pathway and β-arrestin-2 recruitment. It decreases arterial pressure in rat hearts. Synonyms: Elabela (19-32). CAS No. 1886973-05-2. Molecular formula: C75H119N25O17S2. Mole weight: 1707.03. | |
| Eledoisin | Eledoisin is an undecapeptide of mollusk origin and it belongs to the tachykinin family of neuropeptides. It was first isolated from the posterior salivary glands of two mollusk species Eledone muschata and Eledone aldovandi. Eledoisin has the amino acid sequence pGlu-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2. It is the Potent natural tachykinin receptor ligand. Uses: Neurotransmitter agents. Synonyms: Eledone peptide; Eledoisinum; 5-oxo-L-prolyl-L-prolyl-L-seryl-L-lysyl-L-α-aspartyl-L-alanyl-L-phenylalanyl-L-isoleucylglycyl-L-leucyl-L-methioninamide. Grades: >98%. CAS No. 69-25-0. Molecular formula: C54H85N13O15S. Mole weight: 1188.41. | |
| Eledoisin Related Peptide | Eledoisin-Related Peptide, a substance P analogue, is a tachykinin receptor ligand. Synonyms: Eledoisin-Related Peptide; Eledoisin RP; H-Lys-Phe-Ile-Gly-Leu-Met-NH2; L-lysyl-L-phenylalanyl-L-isoleucyl-glycyl-L-leucyl-L-methioninamide; (S)-2,6-diamino-N-((5S,8S,14S,17S)-14-sec-butyl-5-carbamoyl-8-isobutyl-7,10,13,16-tetraoxo-18-phenyl-2-thia-6,9,12,15-tetraazaoctadecan-17-yl)hexanamide; Lpiglm. Grades: ≥95%. CAS No. 2990-43-4. Molecular formula: C34H58N8O6S. Mole weight: 706.94. | |
| Emtricitabine 5-O-Sulfate | Emtricitabine 5-O-Sulfate is a metabolite of Emtricitabine, a reverse transcriptase inhibitor and an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. Synonyms: 4-Amino-5-fluoro-1-[(2R,5S)-2-hydroxymethyl)-1,3-oxathiolan-5-yl]-2-(1H-pyrimidinone 5-O-Sulfate; (-)-2',3'-Dideoxy-5-fluoro-3'--thiacytidine 5-O-Sulfate; (-)-2'-Deoxy-5-fluoro-3'-thiacytidine 5-O-Sulfate; BW 1592 5-O-Sulfate; BW 524W91 5-O-Sulfate; Coviracil 5-O-Sulfate; Emtriva 5-O-Sulfate; (-)-FTC 5-O-Sulfate. Molecular formula: C8H10FN3O6S2. Mole weight: 327.31. | |
| Emtricitabine 5-O-Sulfate-13C,15N2 | Emtricitabine 5-O-Sulfate-13C,15N2 is the isotope labelled analog of Emtricitabine 5-O-Sulfate; a metabolite of Emtricitabine which is a reverse transcriptase inhibitor and an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. Synonyms: 4-Amino-5-fluoro-1-[(2R,5S)-2-hydroxymethyl)-1,3-oxathiolan-5-yl]-2-(1H-pyrimidinone 5-O-Sulfate-13C,15N2; (-)-2',3'-Dideoxy-5-fluoro-3'-thiacytidine 5-O-Sulfate-13C,15N2; (-)-2'-Deoxy-5-fluoro-3'-thiacytidine 5-O-Sulfate-13C,15N2; BW 1592 5-O-Sulfate-13C,15N2; BW 524W91 5-O-Sulfate-13C,15N2; Coviracil 5-O-Sulfate-13C,15N2; Emtriva 5-O-Sulfate-13C,15N2; (-)-FTC 5-O-Sulfate-13C,15N2. Molecular formula: C7[13C]H10FN[15N]2O6S2. Mole weight: 330.29. | |
| Emtricitabine Monophosphate Triethylammonium Salt | A metabolite of (-)-Emtricitabine. Grades: 96%. Molecular formula: C8H11FN3O6PS xC6H15N. Mole weight: 327.23. | |
| Emtricitabine O-β-D-Glucuronide Sodium Salt | Emtricitabine O-β-D-Glucuronide Sodium Salt is a (-)-Emtricitabine metabolite. Synonyms: (2R-cis)-[5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolan-2-yl]methyl β-D-Glucopyranosiduronic Acid Sodium Salt. Molecular formula: C14H17FN3NaO9S. Mole weight: 445.35. | |
| Emtricitabine Phosphonic Acid Triethylammonium Salt | (-)-Emtricitabine derivative. Grades: 95%. Molecular formula: C14H26FN4O5PS. Mole weight: 412.42. | |
| Emtricitabine Tenofovir Disoproxil Dihydrochloride (>90%) | Emtricitabine Tenofovir Disoproxil Dihydrochloride is a derivative of Emtricitabine. Emtricitabine is a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. Grades: 90%. Molecular formula: C28H40FN8O13PS 2HCl. Mole weight: 778.70. | |
| Emtricitabine Tenofovir Monosoproxil | Emtricitabine Tenofovir Monosoproxil is a derivative of Emtricitabine. Emtricitabine is a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. Synonyms: ( ( ( ( ( (R)-1- (6- ( ( ( (5-Fluoro-1- ( (2R, 5S)-2- (hydroxymethyl)-1, 3-oxathiolan-5-yl)-2-oxo-1, 2-dihydropyrimidin-4-yl)amino)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl) (hydroxy)phosphoryl)oxy)methyl Isopropyl Carbonate. Grades: 95%. Molecular formula: C23H32FN8O10PS. Mole weight: 662.58. | |
| (E)-N'-(5-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-oxo-4,5-dihydro-1,3,5-triazin-2-yl)-N,N-dimethylformimidamide | (E)-N'-(5-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-oxo-4,5-dihydro-1,3,5-triazin-2-yl)-N,N-dimethylformimidamide, a chemical compound with potential anti-cancer properties, is a subject of ongoing biomedicine research. Targeting colon and pancreatic cancers, this compound is believed to work by inhibiting DNA synthesis and triggering cellular apoptosis. Synonyms: (E)-N'-(5-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-oxo-4,5-dihydro-1,3,5-Triazine-2-yl)-N,N-dimethylformamide. CAS No. 183016-17-3. Molecular formula: C11H17N5O4. Mole weight: 283.28. | |
| (E)-N'- (5- ( (2R, 4S, 5R)-5- ( (Bis (4-methoxyphenyl) (phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-4-oxo-4, 5-dihydro-1, 3, 5-triazin-2-yl)-N, N-dimethylformimidamide | (E)-N'- (5- ( (2R, 4S, 5R)-5- ( (Bis (4-methoxyphenyl) (phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-4-oxo-4, 5-dihydro-1, 3, 5-triazin-2-yl)-N, N-dimethylformimidamide, a novel compound with potential biomedical applications, exhibits potent anticancer activity against lung and breast cancer. The compound's mechanism of action is believed to involve inhibiting specific enzymes that promote cancer cell proliferation and dissemination. However, more studies are needed to comprehend the therapeutic value of this intriguing compound fully. Synonyms: CS-0064454. Molecular formula: C32H35N5O6. Mole weight: 585.65. | |
| (E)-N'- (9- ( (2R, 3R, 4R)-5- ( (Bis (4-methoxyphenyl) (phenyl)methoxy)methyl)-3- ( (tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6, 9-dihydro-1H-purin-2-yl)-N, N-dimethylformimidamide | (E)-N'- (9- ( (2R, 3R, 4R)-5- ( (Bis (4-methoxyphenyl) (phenyl)methoxy)methyl)-3- ( (tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6, 9-dihydro-1H-purin-2-yl)-N, N-dimethylformimidamide, a novel molecule with potential applications in cancer therapy, has been shown to act by selectively inhibiting certain proteins critical to cancer cell proliferation and survival. Studies performed in preclinical models demonstrated promising results, and efforts to further develop this compound are currently underway. Defining a precise mechanism of action will require more detailed studies of this complex therapeutic candidate. Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[(dimethylamino)methylene]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, (4ξ)-; (4ξ)-5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-N-[(dimethylamino)methylen]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]guanosine. Molecular formula: C40H50N6O7Si. Mole weight: 754.95. | |
| (E)-N'-(9-((2R,3R,4R,5R)-3-((tert-Butyldimethylsilyl)oxy)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide | (E)-N'-(9-((2R,3R,4R,5R)-3-((tert-Butyldimethylsilyl)oxy)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide is a remarkable pharmaceutical compound that functions as a potent and selective inhibitor of DPP-4, a crucial regulator in glucose metabolism. This characteristic identifies it as a potential therapeutic candidate for treating type 2 diabetes, offering a new avenue of hope to those affected by the condition. Despite its complexity and formidable composition, this product demonstrates unparalleled efficacy and promises to make a significant impact in the field of diabetes care. Synonyms: CS-0046519; (E)-N'-(9-((2R,3R,4R,5R)-3-((tert-Butyldimethylsilyl)oxy)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide. Molecular formula: C19H32N6O5Si. Mole weight: 452.58. | |
| (E)-N'-(9-((2R,3R,4R,5R)-4-(Bis(4-methoxyphenyl)(phenyl)methoxy)-3-((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide | (E)-N'-(9-((2R,3R,4R,5R)-4-(Bis(4-methoxyphenyl)(phenyl)methoxy)-3-((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide, a powerful anticancer drug, effectively targets cancer cells by disrupting DNA replication. By inhibiting DNA polymerase, it interrupts the essential process of cell division, thus making it an effective chemotherapy drug against various tumors. This compound displays immense potential as a potent antineoplastic agent and holds significant promise for advanced cancer treatment. Synonyms: (E)-N'-(9-((2R,3R,4R,5R)-4-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-((tert-butyl Dimethylsilyl)oxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethyl formamidine. Molecular formula: C40H50N6O7Si. Mole weight: 754.95. | |
| ENAP-1 | ENAP-1 has antimicrobial activity against Gram-negative and Gram-positive bacteria. | |
| eNAP-2 | ENAP-2 is a novel cysteine-rich bactericidal peptide from equine leukocytes. | |
| Endomorphin 2 | Endomorphin 2, an andogenous peptide, has high affinity and specificity for the μ-opioid receptor and displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM. Uses: Analgesics, opioid. Synonyms: H-Tyr-Pro-Phe-Phe-NH2; L-tyrosyl-L-prolyl-L-phenylalanyl-L-phenylalaninamide; (2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide. Grades: >95%. CAS No. 141801-26-5. Molecular formula: C32H37N5O5. Mole weight: 571.7. | |
| Endopeptidase L4 | Endopeptidase L4 is an antibacterial peptide produced by Lysobacter sp. (strain XL1). | |
| Endothelin-2, human | Endothelin 2 is a ligand for the endothelin (ET) receptors and a potent vasoconstrictor mainly found in the kidney and intestine. Uses: Vasoconstrictor. Synonyms: Endothelin-2 (human, canine); Human endothelin-2; ET-2 (human); H-Cys(1)-Ser-Cys(2)-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys(2)-Val-Tyr-Phe-Cys(1)-His-Leu-Asp-Ile-Ile-Trp-OH; L-cysteinyl-L-seryl-L-cysteinyl-L-seryl-L-seryl-L-tryptophyl-L-leucyl-L-alpha-aspartyl-L-lysyl-L-alpha-glutamyl-L-cysteinyl-L-valyl-L-tyrosyl-L-phenylalanyl-L-cysteinyl-L-histidyl-L-leucyl-L-alpha-aspartyl-L-isoleucyl-L-isoleucyl-L-tryptophan (1->15),(3->11)-bis(disulfide). Grades: ≥95%. CAS No. 123562-20-9. Molecular formula: C115H160N26O32S4. Mole weight: 2546.92. | |
| Endothelin-3, human, mouse, rabbit, rat TFA | Endothelin-3 is a peptide vasoconstricter and a ligand of the endothelin (ET) receptors ETA and ETB (Kbs = 1.05 and 1.49, respectively). It binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB. Synonyms: Endothelin 3 (Rat,Human) (TFA); ET-3 (Rat,Human) (TFA); H-Cys(1)-Thr-Cys(2)-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys(2)-Val-Tyr-Tyr-Cys(1)-His-Leu-Asp-Ile-Ile-Trp-OH.TFA; L-cysteinyl-L-threonyl-L-cysteinyl-L-phenylalanyl-L-threonyl-L-tyrosyl-L-lysyl-L-alpha-aspartyl-L-lysyl-L-alpha-glutamyl-L-cysteinyl-L-valyl-L-tyrosyl-L-tyrosyl-L-cysteinyl-L-histidyl-L-leucyl-L-alpha-aspartyl-L-isoleucyl-L-isoleucyl-L-tryptophan (1->15),(3->11)-bis(disulfide) trifluoroacetic acid; Endothelin-3 (human, rat) trifluoroacetate salt. Grades: ≥95%. Molecular formula: C121H168N26O33S4.C2HF3O2. Mole weight: 2757.07. | |
| Enhancer of rudimentary homolog | ERH is a small, highly conserved protein that has been found in Sus scrofa. It has antibacterial activity. Synonyms: ERH. | |
| Enkelytin | The antibacterial spectrum shows that enkelytin is active against several Gram-positive bacteria including Staphylococcus aureus, but it is unable to inhibit the Gram-negative bacteria growth. | |
| ent-Abacavir | ent-Abacavir (Abacavir EP Impurity A) is an enantiomer of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. Uses: Anti-hiv agents. Synonyms: (1R,4S)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol;(1R-cis)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; (1R,4S)-Abacavir; Abacavir EP Impurity A; Abacavir Impurities; Ent-Abacavir. Grades: 97%. CAS No. 136470-79-6. Molecular formula: C14H18N6O. Mole weight: 286.33. | |
| ent-Emtricitabine 4-Acetamide 5'-O'-Benzoyl | ent-Emtricitabine 4-Acetamide 5'-O'-Benzoyl is a protected intermediate in the ent-Emtricitabine synthesis, a reverse transcriptase inhibitor that is effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. Molecular formula: C17H16FN3O5S. Mole weight: 393.39. | |
| Enterocin 1071 A | Enterocin 1071 A is isolated from Enterococcus faecalis BFE 1071 and has antibacterial activity. Synonyms: Enterocin EntC1 peptide. | |
| Enterocin 7B | Purified Ent7B is active against spoilage microorganisms and foodborne pathogens, including Clostridium sporogenes, Listeria monocytogenes, and Staphylococcus aureus as well as Brevundimonas diminuta, which has been associated with infections among immune-suppressed cancer patients. Synonyms: Ent7B. | |
| Enterocin A | Enterocin A is a classic IIa bacteriocin isolated firstly from Enterococcus faecium CTC492 with selective antimicrobial activity against Listeria strains. However, the application of enterocin A as an anti-Listeria agent has been limited due to its very low native yield. Synonyms: EntA. Molecular formula: C49H70N14O16. Mole weight: 1111.2. | |
| Enterocin B | Enterocin B is a new bacteriocin from Enterococcus faecium T136 which can act synergistically with enterocin A. | |
| Enterocin EJ97 | Enterocin EJ97 is active on several gram-positive bacteria including enterococci, several species of Bacillus, Listeria, and Staphylococcus aureus. Enterocin EJ97 also has a concentration-dependent bactericidal and bacteriolytic effect on E. faecalis S-47. Synonyms: Enterocin EJ97. Molecular formula: C88H144N20O18S2. Mole weight: 5340. | |
| Enterocin-HF | Enterocin HF is an antilisterial bacteriocin produced by Enterococcus faecium M3K31. Synonyms: EntHF. | |
| Enterocin L50A | Enterocin L50A is an antibacterial peptide isolated from Enterococcus faecium. Synonyms: EntL50A. | |
| Enterocin L50B | Enterocin L50B is an antibacterial peptide isolated from Enterococcus faecium. Synonyms: EntL50B. | |
| Enterocin NKR-5-3D | Enterocin NKR-5-3D is active against select Gram-positive bacteria. In addition, it induces the production of other entericins such as NKR-5-3A, NKR-5-3B, and NKR-5-3C. Enterocin NKR-5-3D was found in Enterococcus faecium. Grades: >95% by HPLC. | |
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