BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| (Z)-HA-155 | HA-155 is an autotaxin inhibitor. Autotaxin, also known as ectonucleotide pyrophosphatase/phosphodiesterase 2 (NPP2 or ENPP2), is a secreted enzyme converting lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA), which is responsible for tumor cell motility stimulation. Synonyms: (Z)-HA 155; (Z)-HA155; Boronic acid, B-[4-[[4-[[3-[(4-fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-. Grade: >98%. CAS No. 1312201-00-5. Molecular formula: C24H19BFNO5S. Mole weight: 463.3. |  |
| (Z)-JIB-04 | (Z)-JIB-04 is a Z-isomer of JIB-04, which is a small-molecule histone demethylase inhibitor with antitumor activity. JIB-04 selectively inhibits tumor growth via targeting various tumorigenic signaling pathways. Synonyms: 5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine; JIB-04 Z-isomer. CAS No. 199596-24-2. Molecular formula: C17H13ClN4. Mole weight: 308.769. | |
| (Z)-Lanoconazole | (Z)-Lanoconazole is the Z configuration of Lanoconazole, which is a potent and orally active imidazole antifungal agent with a broad spectrum antifungal activities in vitro and in vivo. Synonyms: (2Z)-[4-(2-Chlorophenyl)-1,3-dithiolan-2-ylidene](1H-imidazol-1-yl)acetonitrile; 1H-Imidazole-1-acetonitrile, α-[4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene]-, (αZ)-; (Z)-2-[4-(2-Chlorophenyl)-1,3-dithiolane-2-ylidene]-2-(1-imidazolyl)acetonitrile. Grade: ≥95%. Molecular formula: C14H10ClN3S2. Mole weight: 319.83. | |
| (Z)-Leukadherin-1 | (Z)-Leukadherin-1, an orally active and allosteric CD11b agonist, leads to repolarization of tumor-associated macrophages, reduces the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell response. Synonyms: ADH-503 free base; (Z)-4-(5-((3-benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid; Benzoic acid, 4-[5-[(Z)-[4-oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-; 4-{5-[(Z)-(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-2-furyl}benzoic acid. Grade: ≥98%. CAS No. 2055362-72-4. Molecular formula: C22H15NO4S2. Mole weight: 421.49. | |
| (Z)-MDL 105519 | (Z)-MDL 105519 is the inactive isoform of MDL 105519 which is a high affinity NMDA glutamate receptor antagonist at the glycine site. Synonyms: (Z)-MDL 105519; (Z)-MDL105519; (Z)-MDL-105519. CAS No. 179105-67-0. Molecular formula: C18H11Cl2NO4. Mole weight: 376.19. | |
| (Z)-methyl 3-((2'-(N'-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylate | (Z)-methyl 3-((2'-(N'-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylate is an impurity of Azilsartan, an angiotensin II receptor blocker (ARB) used to treat high blood pressure. Grade: 98%. CAS No. 1499167-72-4. Molecular formula: C23H20N4O4. Mole weight: 416.43. | |
| (Z)-Methyl 3-(((4-(N-methyl-2-(piperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: Nintedanib metabolite M3; Nintedanib impurity I; 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[2-(1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)-. Grade: ≥95%. CAS No. 334951-61-0. Molecular formula: C30H31N5O4. Mole weight: 525.60. | |
| (Z)-Mycophenolic Acid | An impurity of Mycophenolic which inhibits an enzyme needed for the growth of T cells and B cells. Synonyms: (4Z)-6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic Acid. Grade: > 95%. CAS No. 483-60-3. Molecular formula: C17H20O6. Mole weight: 320.35. | |
| (Z)-N-(2,2-Dimethoxyethyl)-2-(2-(tritylamino)thiazol-4-yl)-2-((trityloxy)imino)acetamide | (Z)-N-(2,2-Dimethoxyethyl)-2-(2-(tritylamino)thiazol-4-yl)-2-((trityloxy)imino)acetamide is one of Cefdinir impurities. Cefdinir is a semi-synthetic, broad-spectrum antibiotic, used for soft tissue infections and respiratory tract infections. Molecular formula: C47H42N4O4S. Mole weight: 758.92. | |
| (Z)-O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenyl carbamate | O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenyl carbamate, with its distinctive molecular composition, serves as an exceptional therapeutic agent utilized in the management of diverse pathological conditions. Notably, this invaluable biomedicine demonstrates exceptional effectiveness in counteracting specific malignancies, such as leukemia and solid tumors, making it an invaluable asset in combating neoplastic disorders. Functioning as a targeted remedy, it efficaciously disrupts the proliferation and growth of malignant cells. Synonyms: PugNAc; (Z)-PugNAc; D-Gluconimidic acid, 2-(acetylamino)-2-deoxy-N-[[(phenylamino)carbonyl]oxy]-, δ-lactone, (1Z)-; N-Acetylglucosaminono-1,5-lactone O-(phenylcarbamoyl)oxime; (Z)-O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-Phenylcarbamate; O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenyl carbamate. CAS No. 132489-69-1. Molecular formula: C15H19N3O7. Mole weight: 353.33. | |
| (Z)-Olopatadine N-Oxide | (Z)-Olopatadine N-Oxide is a metabolite of Olopatadine, which is a histamine blocker and mast cell stabilizer. Synonyms: Olopatadine Related Compound B (USP); (Z)-3-(2-(Carboxymethyl)dibenzo(b,E)oxepin-11(6H)-ylidene(-N,N-dimethylpropan-1-amine oxide. Grade: 98%. CAS No. 173174-07-7. Molecular formula: C21H23NO4. Mole weight: 353.41. | |
| (Z)-Orantinib | (Z)-Orantinib is a potent, selective, orally active and ATP competitive Flk-1/KDR, PDGFRβ and FGFR1 inhibitor, with IC50s of 2.1, 0.008 and 1.2 μM, respectively. It is a potent antiangiogenic and antineoplastic agent that induces established tumor regression. Uses: Protein kinase inhibitors. Synonyms: (Z)-SU6668; (Z)-TSU-68; PDGFR Tyrosine Kinase Inhibitor VI; (Z)?-3-(2,?4-Dimethyl-5-((2-oxoindolin-3-ylidene)?methyl)?-1H-pyrrol-3-yl)?propanoic acid; 5-[(Z)?-(1,?2-Dihydro-2-oxo-3H-indol-3-ylidene)?methyl]?-2,?4-dimethyl-1H-pyrrole-3-propanoic Acid; NSC 702827; 1H-Pyrrole-3-propanoic acid, 5-[(Z)-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-. Grade: >97%. CAS No. 210644-62-5. Molecular formula: C18H18N2O3. Mole weight: 310.35. | |
| (Z)-Penicillin F | (Z)-Penicillin F is an impurity of Penicillin. Penicillin belongs to the β-lactam class of antibiotics, is a very common antibacterial drug. Molecular formula: C14H20N2O4S. Mole weight: 312.38. | |
| (Z)-Pitavastatin Calcium Salt | An impurity of Pitavastatin which is a relatively newly developed cholesterol lowering agent used to lower high cholesterol and triglycerides in certain patients. Synonyms: (Z)-Pitavastatin Calcium Salt; 1159588-21-2; (Z,3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate. Grade: > 95%. CAS No. 1159588-21-2. Molecular formula: C50H46F2N2O8.Ca. Mole weight: 881.01. | |
| (Z)-rac-Luliconazole | (Z)-rac-Luliconazole is a stereoisomer of Luliconazole which is an azole antifungal drug. Synonyms: (Z)-α-[4-(2,4-Dichlorophenyl)-1,3-dithiolan-2-ylidene]-1H-imidazole-1-acetonitrile. Grade: > 95%. CAS No. 101529-76-4. Molecular formula: C14H9Cl2N3S2. Mole weight: 354.28. | |
| (Z)-SMI-4a | (Z)-SMI-4a is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM for Pim-1 compared to an IC50 of 100 nM for Pim-2 and with little or no activity against a panel of 50 other kinases tested. Synonyms: SMI-4a; SMI4a; SMI 4a; TCS PIM-1 4a. CAS No. 438190-29-5. Molecular formula: C11H6F3NO2S. Mole weight: 273.229. | |
| (Z)-SU4312 | (Z)-SU4312 is an inhibitor of MAO-B and NOS with IC50s of 0.2 and 19.0 μM, respectively. Synonyms: 2H-Indol-2-one, 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-, (3Z)-; (3Z)-3-[[4-(Dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one; 2H-Indol-2-one, 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-, (Z)-; (Z)-3-(4-(Dimethylamino)benzylidene)indolin-2-one; cis-SU 4312. Grade: ≥95%. CAS No. 90828-16-3. Molecular formula: C17H16N2O. Mole weight: 264.32. | |
| (Z)-Sulindac Sulfide | (Z)-Sulindac Sulfide is a highly potent anti-inflammatory compound, finding essential application in the research of diverse ailments like colorectal cancer, familial adenomatous polyposis (FAP) and numerous inflammatory disorders. This compound's remarkable mechanism entails the inhibition of cyclooxygenase (COX) enzymes, leading to a reduction in prostaglandin production and consequent suppression of inflammatory responses. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylthio)?phenyl]?methylene]?-, (1Z)?-; cis-Sulindac sulfide. Grade: 95%. CAS No. 49627-27-2. Molecular formula: C20H17FO2S. Mole weight: 340.418. | |
| (Z)-tert-Butyl 2-(2-(2-(Tritylamino)thiazol-4-yl)-2-((trityloxy)imino)acetamido)acetate | (Z)-tert-Butyl 2-(2-(2-(Tritylamino)thiazol-4-yl)-2-((trityloxy)imino)acetamido)acetate is one of Cefdinir intermediates. Cefdinir is a semi-synthetic, broad-spectrum antibiotic, used for soft tissue infections and respiratory tract infections. Synonyms: 2-Methyl-2-propanyl N-{(2Z)-2-[2-(tritylamino)-1,3-thiazol-4-yl]-2-[(trityloxy)imino]acetyl}glycinate; Glycine, N-[(2Z)-1-oxo-2-[(triphenylmethoxy)imino]-2-[2-[(triphenylmethyl)amino]-4-thiazolyl]ethyl]-, 1,1-dimethylethyl ester. Molecular formula: C49H44N4O4S. Mole weight: 784.96. | |
| (Z,Z)-5,11-Eicosadienoic Acid-5,6,11,12-[d4] | (Z,Z)-5,11-Eicosadienoic Acid-5,6,11,12-[d4]. Uses: Labelled (z,z)-5,11-eicosadienoic acid. Synonyms: (5Z,11Z)-5,11-Eicosadienoic Acid-d4; (5Z,11Z)-Eicosadienoic Acid-d4; Keteleeronic Acid-d4; all-cis-5,11-Eicosadienoic Acid-d4; (Z,Z)-5,11-Eicosadienoic Acid-d4; (5Z,11Z)-icosa-5,11-dienoic-5,6,11,12-d4 acid; (5Z,11Z)-5,11-Eicosadienoic-5,6,11,12-d4 acid; 5,11-Eicosadienoic-5,6,11,12-d4 acid, (5Z,11Z)-. CAS No. 1268627-54-8. Molecular formula: C20H32D4O2. Mole weight: 312.52. | |
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