BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
A Fmoc protected leucine derivative that may be used in proteomics studies and solid phase peptide synthesis. Synonyms: Fmoc-Leu-ol; Fmoc-Leucinol; (S)-(9H-Fluoren-9-yl)methyl (1-hydroxy-4-methylpentan-2-yl)carbamate; 9H-fluoren-9-ylmethyl N-[(2S)-1-hydroxy-4-methylpentan-2-yl]carbamate. Grades: ≥ 98 % (HPLC). CAS No. 139551-83-0. Molecular formula: C21H25NO3. Mole weight: 339.4.
Fmoc-L-phenylalaninol
Fmoc-L-phenylalaninol (CAS# 129397-83-7) is a useful research chemical. Synonyms: Fmoc-Phe-ol; Fmoc-Phenylalaninol; (S)-(9H-Fluoren-9-yl)methyl (1-hydroxy-3-phenylpropan-2-yl)carbamate; 9H-fluoren-9-ylmethyl N-[(2S)-1-hydroxy-3-phenylpropan-2-yl]carbamate. Grades: ≥ 99 % (HPLC). CAS No. 129397-83-7. Molecular formula: C24H23NO3. Mole weight: 373.40.
Fmoc-O-tert-butyl-L-threoninol (CAS# 189337-28-8) is a useful research chemical. Synonyms: Fmoc-L-Threoninol(tBu); Fmoc-L-Thr(tBu)-ol; (9H-Fluoren-9-yl)methyl ((2R,3R)-3-(tert-butoxy)-1-hydroxybutan-2-yl)carbamate; (2R,3R)-2-(Fmoc-amino)-3-tert-butoxy-1-butanol. Grades: ≥ 98 % (HPLC). CAS No. 189337-28-8. Molecular formula: C23H29NO4. Mole weight: 383.50.
Fmoc-Phe-OH-[15N]
Fmoc-Phe-OH-[15N] is the labelled analogue of L-Phenylalanine-N-FMOC. Phenylalanine is an α-amino acid essential for humans that is found in breast milk of mammals. It is commonly used as a dietary supplement. Synonyms: N-(9-Fluorenylmethoxycarbonyl)-L-phenylalanine-15N; L-Phenylalanine-15N N-Fmoc; Fmoc-[15N]Phe-OH; (((9H-Fluoren-9-yl)methoxy)carbonyl)-L-phenylalanine-15N. Grades: 99% (CP); 98% atom 15N. CAS No. 125700-32-5. Molecular formula: C24H21[15N]O4. Mole weight: 388.42.
Fmoc-piperazine hydrochloride
Fmoc-piperazine hydrochloride (CAS# 215190-22-0) is a useful research chemical. Synonyms: Fmoc-Piz HCl. Grades: > 98 %. CAS No. 215190-22-0. Molecular formula: C19H21N2O2Cl. Mole weight: 344.8.
Fmoc-(R)-3-amino-4-(2,4,5-trifluorophenyl)butyric Acid is an impurity of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Synonyms: N-β-(9-Fluorenylmethoxycarbonyl)-2,4,5-trifluoro-D-β-homophenylalanine; (R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic acid. Grades: >95%. CAS No. 1217818-53-5. Molecular formula: C25H20F3NO4. Mole weight: 455.43.
Synonyms: N-(9-Fluorenylmethoxycarbonyl)-L-valine-15N; Fmoc-Val-OH-15N. Grades: 99% by CP; 98% atom 15N. CAS No. 125700-35-8. Molecular formula: C20H21[15N]O4. Mole weight: 340.38.
FMRF
FMRF is a peptide consisting of 4 amino acid residues. Uses: Membrane transport modulators. Synonyms: L-Phenylalanine, L-phenylalanyl-L-methionyl-L-arginyl-; Phenylalanyl-Methionyl-Arginyl-Phenylalanin; H-Phe-Met-Arg-Phe-OH; H-FMRF-OH. Grades: ≥95%. CAS No. 74012-06-9. Molecular formula: C29H41N7O5S. Mole weight: 599.74.
Formaecin-1
Formaecin-1 is an antibacterial peptide isolated from Myrmecia gulos. It has activity against E.coli but none against other Gram-negative bacteria and Gram-positive bacteria.
Formaecin-2
Formaecin 2 was an antibacterial peptide found in Red bulldog ant Myrmecia gulosa. It has activity against E.coli but none against other Gram-negative bacteria and Gram-positive bacteria. Rich in Proline. Grades: >95% by HPLC.
Formylindole-dT CEP
Formylindole-dT CEP is a crucial compound in biomedicine used to enhance the efficiency of DNA sequencing. It serves as a modified nucleotide in the synthesis of oligonucleotides for research purposes. With its unique structure, Formylindole-dT CEP can be incorporated into DNA strands, allowing for precise identification and analysis of gene mutations associated with various diseases, including cancer and genetic disorders. Molecular formula: C59H70N7O11P. Mole weight: 1084.20.
Fowlicidin-2
Fowlicidin-2, which is composed of 31 amino acids, is widely expressed in the majority of tissues in chickens and has an important role in innate immunity.
Fowlicidin 3
Fowlicidin-3 is an alpha-helical cationic host defense peptide with potent antibacterial and lipopolysaccharide-neutralizing activities. It is highly potent against a broad range of Gram-negative and Gram-positive bacteria in vitro, including antibiotic-resistant strains, with minimum inhibitory concentrations in the range 1-2 microM.
Foxy-5
A Wnt5a peptide mimetic. It has been undergoing clinical trials for the treatment of prostate cancer, colorectal cancer, metastatic colon cancer, metastatic breast cancer, and metastatic prostate cancer. Synonyms: Foxy 5; Foxy5; (2S) -2- [ [ (2S) -4-carboxy-2- [ [ (2R) -2- [ [2- [ [ (2S) -3-carboxy-2- [ [ (2S) -2-formamido-4-methylsulfanylbutanoyl] amino] propanoyl] amino] acetyl] amino] -3-sulfanylpropanoyl] amino] butanoyl] amino] -4-methylpentanoic acid. Grades: >95%. CAS No. 881188-51-8. Molecular formula: C26H42N6O12S2. Mole weight: 694.8.
FR 901379
FR 901379 is an impurity of Micafungin, a lipopeptide compound that acts as an antifungal agent with activity against Aspergillus and Candida species. FR901379 is an echinocandin-like antifungal lipopeptide with inhibitory activity against C. albicans, C. krusei, C. tropicalis, C. utilis, A. fumigatus, and A. niger fungi (IC50s = <0.003-1.9 μg/ml). FR 901379 has a protective effect against C. albicans infection in mice (ED50 = 1.1 mg/kg). It also reduces the number of lung cysts and trophozoites in a mouse model of Plasmodium carinii infection. Synonyms: 1-[(4R,5R)-4,5-Dihydroxy-N2-(1-oxohexadecyl)-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]pneumocandin A0; (2α,3β,4β)-(4R,5R)-4,5-Dihydroxy-N2-(1-oxohexadecyl)-L-ornithyl-L-threonyl-trans-4-hydroxy-L-prolyl-(S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonyl-3-hydroxy-L-glutaminyl-3-hydroxy-4-methyl-L-Proline Cyclic (6?1)-Peptide; 1H-Dipyrrolo[2, 1-c:2', 1'-l][1, 4, 7, 10, 13, 16]hexaazacycloheneicosine Cyclic Peptide Deriv. Grades: ≥90%. CAS No. 144371-88-0. Molecular formula: C51H82N8O21S. Mole weight: 1175.30.
Frenatin-1
Frenatin-1 is an antimicrobial peptide with selective activity. Frenatin-1 is only active against Micrococcus luteus (MIC=25 μg/ml) and not against Bacillus cereus, Escherichia coli, Leuconostoc mesenteroides, Micrococcus luteus, Pastewella haemolytica, Staphylococcus aureus, Streptococcus faecalis and Streptococcus uberis.
Frenatin-2
Frenatin-2 is an antimicrobial peptide with selective activity. Frenatin-2 is only active against Micrococcus luteus (MIMC=50 μg/ml) and not against Bacillus cereus, Escherichia coli, Leuconostoc mesenteroides, Micrococcus luteus, Pastewella haemolytica, Staphylococcus aureus, Streptococcus faecalis and Streptococcus uberis.
Frenatin 3
Frenatin 3 inhibits the production of nitric oxide by the enzyme neuronal nitric oxide synthase at a micromolar concentration by binding to its regulatory protein, Ca2+ calmodulin, a protein known to recognize and bind amphipathic alpha-helices. Grades: >95% by HPLC. Molecular formula: C88H146N24O24S. Mole weight: 1956.31.
Frenatin-3
The peptide frenatin 3 is a major component of the skin secretion of the Australian giant tree frog, Litoria infrafrenata.
FSL-1
FSL 1 is a TLR2/6 peptide agonist (also a putative TLR10 ligand) that activates NF-κB. FSL 1 induces the expression of some pro-inflammatory cytokines such as IL-8, IL-1β, CCL20 and TNF-α in vitro. Synonyms: FSL 1; FSL1; L-Phenylalanine, S-[2,3-bis[(1-oxohexadecyl)oxy]propyl]-L-cysteinylglycyl-L-α-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-; S-[2,3-Bis[(1-oxohexadecyl)oxy]propyl]-L-cysteinylglycyl-L-α-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-L-phenylalanine; FSL-1 lipoprotein, synthetic; Fibroblast-stimulating lipopeptide-1; Pam2-Cys-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe-OH. Grades: ≥95%. CAS No. 322455-70-9. Molecular formula: C84H140N14O18S. Mole weight: 1666.16.
FSLLRY-NH2
FSLLRY-NH2 is a selective PAR2 peptide antagonist. It reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice, also suppresses ERK activation and collagen production in isolated cardiac fibroblasts. Synonyms: [Phe1,Ser2,Tyr6]-PAR-1 (1-6) amide (human). CAS No. 245329-02-6. Molecular formula: C39H60N10O8. Mole weight: 796.97.
Fusaricidin A
Fusaricidin A, a new depsipeptide antibiotic, was isolated from the culture broth of Bacillus polymyxa KT-8 obtained from the rhizosphere of garlic suffering from the basal rot caused by Fusarium oxysporum. Fusaricidin A is active against fungi and Gram-positive bacteria. Synonyms: 1-Oxa-4,7,10,13,16-pentaazacyclononadecane-6-acetamide, 18-[[15-[[(Z)-aminoiminomethyl]amino]-3-hydroxy-1-oxopentadecyl]amino]-9-[(1R)-1-hydroxyethyl]-3,19-dimethyl-12,15-bis(1-methylethyl)-2,5,8,11,1 4,17-hexaoxo-, (3R,6R,9R,12S,15R,18S,19R)-. Molecular formula: C41H74N10O11. Mole weight: 883.08.
Fusaricidin B
Fusaricidins B, a new depsipeptide antibiotic, has been isolated as a minor component from the culture broth of Bacillus polymyxa KT-8 which was obtained from the rhizosphere of garlic suffering from the basal rot caused by Fusarium oxysporum. Fusaricidins B is active against fungi and Gram-positive bacteria almost as well as fusaricidin A. Molecular formula: C42H76N10O11. Mole weight: 897.11.
Fusaricidin C
Fusaricidins C, a new depsipeptide antibiotic, has been isolated as a minor component from the culture broth of Bacillus polymyxa KT-8 which was obtained from the rhizosphere of garlic suffering from the basal rot caused by Fusarium oxysporum. Fusaricidins C is active against fungi and Gram-positive bacteria almost as well as fusaricidin A. Molecular formula: C45H74N10O12. Mole weight: 947.13.
Fusaricidin D
Fusaricidins D, a new depsipeptide antibiotic, has been isolated as a minor component from the culture broth of Bacillus polymyxa KT-8 which was obtained from the rhizosphere of garlic suffering from the basal rot caused by Fusarium oxysporum. Fusaricidins D is active against fungi and Gram-positive bacteria almost as well as fusaricidin A. Molecular formula: C46H76N10O12. Mole weight: 961.15.
Futalosine
A new nucleoside analog, was isolated from a fermentation broth of Streptomyces sp. MK359-NF1. An antibiotic cancer inhibitor. Synonyms: 3-[1,5,6-Trideoxy-1-(1,6-dihydro-6-oxo-9H-purin-9-yl)-β-D-ribo-heptofuranuronoyl]benzoic Acid. CAS No. 210644-32-9. Molecular formula: C19H18N4O7. Mole weight: 414.37.
G280-9
G280-9 is a natural epitope peptide containing 9 amino acids and is also a relevant target for melanoma expression. Synonyms: 95 kDa Melanocyte-Specific Secreted Glycoprotein (256-264) (human, bovine, mouse); Melanocyte Lineage-Specific Antigen GP100 (256-264) (human, bovine, mouse); ME20-M/ME20-S (256-264) (human, bovine, mouse); H-Tyr-Leu-Glu-Pro-Gly-Pro-Val-Thr-Ala-OH; L-tyrosyl-L-leucyl-L-alpha-glutamyl-L-prolyl-glycyl-L-prolyl-L-valyl-L-threonyl-L-alanine; Melanocyte Protein PMEL 17 (256-264) (human, bovine, mouse). Grades: ≥95%. CAS No. 156761-76-1. Molecular formula: C44H67N9O14. Mole weight: 946.05.
Gaegurin-1
The source is Glandirana rugosa. Gaegurin-1 has a non-hemolytic activity. It has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, fungi and protozoa. Synonyms: GGN1.
Gaegurin-2
The source is Glandirana rugosa. Gaegurin-2 has a non-hemolytic activity. It has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, fungi and protozoa. Synonyms: GGN2.
Gaegurin-3
The source is Glandirana rugosa. Gaegurin-3 has a non-hemolytic activity. It has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, fungi and protozoa. Synonyms: GGN3.