BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
Guanosine, 3'-deoxy-2'-O-(1,1-difluoro-2-methoxyethyl)-3'-[[(4-methoxyphenyl)diphenylmethyl]amino]-N-(2-methyl-1-oxopropyl), 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is a chemical utilized in RNA synthesis. It serves as a modified nucleoside to improve the binding affinity of RNA with therapeutic drugs in treating viral diseases such as HIV and hepatitis C. Synonyms: ( (2S, 3R, 4R, 5R) -5- (6-benzamido-2-isobutyramido-9H-purin-9-yl) -4- (1, 1-difluoro-2-methoxyethoxy) -3- ( ( (4-methoxyphenyl) diphenylmethyl) amino) tetrahydrofuran-2-yl) methyl (2-cyanoethyl) diisopropylphosphoramidite. CAS No. 2299279-99-3. Molecular formula: C46H57F2N8O8P. Mole weight: 918.96.
Guanosine, 3'-deoxy-2'-O-(2-methoxyethyl)-3'-[[(4-methoxyphenyl)diphenylmethyl]amino]-N-(2-methyl-1-oxopropyl) is an exquisite biomedical compound, renowned for its antiviral prowess. It diligently aids to study pernicious viral infections such as hepatitis C and herpes simplex. CAS No. 2299278-41-2. Molecular formula: C37H42N6O7. Mole weight: 682.77.
Guanosine, 3'-deoxy-2'-O-(2-methoxyethyl)-3'-[[(4-methoxyphenyl)diphenylmethyl]amino]-N-(2-methyl-1-oxopropyl)-, 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is an indispensable compound employed extensively in the realm of biomedical exploration, specifically in nucleic acid synthesis. This remarkable compound acts as a modulated foundational unit in the paradigm of solid-phase DNA synthesis, consequently enabling the assimilation of aforementioned guanosine variant into the very fabric of DNA filaments. By virtue of its distinctive phosphoramidite structure, this exemplary specimen facilitates focused inquiry into precise DNA modifications. Synonyms: ( (2S, 3R, 4R, 5R) -5- (6-benzamido-2-isobutyramido-9H-purin-9-yl) -4- (2-methoxyethoxy) -3- ( ( (4-methoxyphenyl) diphenylmethyl) amino) tetrahydrofuran-2-yl) methyl (2-cyanoethyl) diisopropylphosphoramidite. CAS No. 2299278-14-9. Molecular formula: C46H59N8O8P. Mole weight: 882.98.
Guanosine, 3'-deoxy-2'-O-ethyl-3'-[[ (4-methoxyphenyl) ?diphenylmethyl]?amino]?-N- (2-methyl-1-oxopropyl) ?-, 5'-[2-cyanoethyl N,?N-bis(1-methylethyl)?phosphoramidite] is a pivotal constituent, emanates as a linchpin in the explicit domain of nucleic acid synthesis, intently within DNA and RNA exploration. It confers enhanced prospects for manufacturing modified nucleotides as well as derivatives pertaining to nucleic acids, necessitated for investigations encompassing the structural, functional and behavioral attributes pertinent to DNA and RNA molecules, rendering significant insights. Synonyms: 2-cyanoethyl ( ( (2S, 3R, 4R, 5R) -4-ethoxy-5- (2-isobutyramido-6-oxo-1, 6-dihydro-9H-purin-9-yl) -3- ( ( (4-methoxyphenyl) diphenylmethyl) amino) tetrahydrofuran-2-yl) methyl) diisopropylphosphoramidite. CAS No. 2299279-11-9. Molecular formula: C45H57N8O7P. Mole weight: 852.96.
Guanosine, 3'-deoxy-3'-[[(4-methoxyphenyl)diphenylmethyl]amino]-N-(2-methyl-1-oxopropyl)-2'-O-2-propen-1-yl-, 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] serves as an indispensable compound within the biomedical sector, utilized for the synthesis of modified nucleotides. Its paramount importance lies in its significant contribution to the advancement of nucleic acid-based therapeutics, including antisense oligonucleotides, siRNAs and aptamers. Synonyms: ( (2S, 3R, 4R, 5R) -4- (allyloxy) -5- (6-benzamido-2-isobutyramido-9H-purin-9-yl) -3- ( ( (4-methoxyphenyl) diphenylmethyl) amino) tetrahydrofuran-2-yl) methyl (2-cyanoethyl) diisopropylphosphoramidite. CAS No. 2299283-17-1. Molecular formula: C46H57N8O7P. Mole weight: 864.97.
Guanosine, 3'-O-[(1,?1-dimethylethyl)?dimethylsilyl]?-2'-O-methyl-N-(2-methyl-1-oxopropyl)? - the nucleoside analog believed to hold great potential in the fight against a wide range of viral infections and certain cancers. Extensively researched for its ability to disrupt viral or cancerous DNA replication, Guanosine, 3'-O-[(1,?1-dimethylethyl)?dimethylsilyl]?-2'-O-methyl-N-(2-methyl-1-oxopropyl)? has been shown to be effective against HCV, HIV, herpes simplex virus, leukemia and lung cancer - making it a powerful tool in the battle against these debilitating diseases. Synonyms: 3'-O-[(1,1-Dimethylethyl)dimethylsilyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)guanosine. CAS No. 863097-97-6. Molecular formula: C21H35N5O6Si. Mole weight: 481.62.
Guanosine, 4'-?C-?ethenyl-
4'-C-ethenyl-guanosine is an indispensable biomolecule employed in the realm of biomedical investigation. It primarily finds application in the fabrication and research of antiviral compounds, especially for studying maladies instigated by RNA viruses. As a precursor to nucleic acids, this compound plays a pivotal role in restraining viral duplication and studying perilous contagions. CAS No. 1892590-33-8. Molecular formula: C12H15N5O5. Mole weight: 309.28.
Guanosine-5'-[(beta,gamma)-imido]triphosphate sodium salt
Guanosine-5'-[(beta,gamma)-imido]triphosphate sodium salt is a vital compound extensively used in biomedical field for its role as a potent activator of G protein-coupled receptors (GPCRs). It facilitates signal transduction pathways in various cellular processes, including neurotransmission, hormone regulation and immune responses. Synonyms: GMPPNP; GppNHp. Molecular formula: C10H17N6O13P3·xNa. Mole weight: 522.20 (free acid).
Guanosine-5'-[(beta,gamma)-methyleno]triphosphate sodium salt
Guanosine 5'-[beta,gamma-methylene]triphosphate is a nucleoside triphosphate analogue that is guanosine substituted at position 5' by a (beta,gamma-methylene)triphosphate group. It is a conjugate acid of a guanosine 5'-[beta,gamma-methylene]triphosphate(4-). Synonyms: GMPPCP; GppCp. Molecular formula: C11H18N5O13P3·xNa. Mole weight: 521.21 (free acid).
Guanosine-5'-carboxylic acid
Guanosine-5'-carboxylic acid, a pivotal component in the realm of biomedicine, holds immense importance. Its primary role revolves around the exploration and innovation of antiviral pharmaceuticals, with a specific focus on tackling herpes simplex and varicella-zoster viruses. By serving as a fundamental cornerstone for the synthesis of robust antiviral agents, this compound actively drives significant progress in the treatment landscape of viral ailments. Synonyms: 1-(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)-1-deoxy-b-D-ribofuranuronic acid; (2S,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydro-2-furancarboxylic acid; 5'-Guanylsaeure; guanosine-5'-carboxylic acid; 1-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-β-D-1-deoxy-ribofuranuronic acid. Grades: ≥ 95%. CAS No. 15596-14-2. Molecular formula: C10H11N5O6. Mole weight: 297.22.
Guanosine 5'-Diphosphate Triammonium Salt is an intermediate in the eukaryotic messenger ribonucleic acid cap binding protein synthesis. Synonyms: Guanosine 5'-(Trihydrogen Diphosphate), Triammonium Salt; Triammonium Guanosine 5'-Diphosphate. CAS No. 79441-34-2. Molecular formula: C10H16N6O11P2. Mole weight: 458.22.
Guanosine 5'-Monophosphate Ester 6-Deoxytalose Sodium Salt
Guanosine 5'-Monophosphate Ester 6-Deoxytalose Sodium Salt is used in the synthetic preparation of nucleoside monophosphate sugars such as GMP-Fucose. Synonyms: 5'-Guanylic Acid Mono(6-deoxy-α-L-galactopyranosyl) Ester Sodium Salt. Molecular formula: C16H23N5NaO12P. Mole weight: 531.34.
Guanosine-5'-monophosphate triethylammonium salt
Guanosine-5'-monophosphate triethylammonium salt is an indispensable biomedical compound, displays inhibitory efficacy against a wide spectrum of diseases such as cancer and autoimmune disorders. This extraordinary therapeutic exemplar meticulously regulates intricate cellular signaling cascades while actively stimulating prosperous cellular proliferation. Molecular formula: C22H44N7O8P. Mole weight: 565.61.
Guanosine 5'-O-(1-thiotriphosphate) lithium salt
Guanosine 5'-O-(1-thiotriphosphate) lithium salt is an exquisite compound ubiquitous in the biomedical arena aiding in studying a myriad of diseases intricately intertwined with cellular signaling and nucleotide metabolism. Within the realm of scientific exploration, it frequently serves as an indispensable tool for unraveling the mysteries enshrouding G-protein coupled receptor signaling cascades, as well as delving into the profound impact guanine nucleotides bestow upon fundamental cellular phenomena like cellular proliferation and differentiation. Synonyms: a-Thio-GTP. Molecular formula: C10H16N5O13P3S·4Li. Mole weight: 567.01.
Guanosine, 5'-O-[bis (4-methoxyphenyl) ?phenylmethyl]?-2'-O-[ (1, ?1-dimethylethyl) ?dimethylsilyl]?-N- (2-methyl-1-oxopropyl) ?-4'-thio- is an exceptionally intricate and groundbreaking biomedical compound meticulously engineered to inhibit malignancy cells and impede their exponential growth by intricately obstructing vital signaling pathways profoundly involved in the relentless advancement of malignant tumors. CAS No. 2080404-29-9. Molecular formula: C41H51N5O7SSi. Mole weight: 786.02.
Compound XYZ is a biomedical compound embodied with remarkable antioxidant and anti-inflammatory prowess, aiding in studying cancer, cardiovascular diseases and neurodegenerative disorders. CAS No. 2080404-28-8. Molecular formula: C41H51N5O7SSi. Mole weight: 786.02.
Guanosine 5'-Pyrophosphate Ester 6-Deoxytalose (>90%) Disodium Salt
Guanosine 5'-Pyrophosphate Ester 6-Deoxytalose has been used to study guanosine diphosphate-4-keto-D-rhamnose reductase enzyme catalysis. Synonyms: P'-(6-Deoxy-α-D-talopyranosyl) Ester Guanosine 5'-(Trihydrogen Diphosphate) Disodium Salt; Mono(6-deoxy-α-D-talopyranosyl) Ester Guanosine 5'-(Trihydrogen Pyrophosphate) Disodium Salt; Guanosine 5'-Pyrophosphate, Ester α-D-6-Deoxytalopyranosyl Disodium Salt; 6-Deoxytalopyranose 1-Ester Guanosine 5'-(Trihydrogen Pyrophosphate) Disodium Salt. Molecular formula: C16H23N5Na2O15P2. Mole weight: 633.31.
Guanosine 5'-triphosphate tetrasodium salt
Guanosine 5'-triphosphate tetrasodium salt is a paramount compound in the biomedical sector, serving as a pivotal precursor engendering diverse enzymatic reactions. Notably, it finds ubiquitous employment in research laboratories to elucidate G-protein coupled receptor signaling pathways, cellular energy transference and signal transduction mechanisms. Synonyms: Tetrasodium guanosine triphosphate; Guanosine 5'-(tetrasodium triphosphate); Tetrasodium 5'-O- ({[ (phosphonatooxy) phosphinato]oxy}phosphinato) guanosine; Guanosine, 5'-(tetrahydrogen triphosphate), sodium salt (1:4). Grades: ≥97% by HPLC. CAS No. 14356-96-8. Molecular formula: C10H12N5Na4O14P3. Mole weight: 611.11.
Guanosine 5,-triphosphoric aicd disodium salt
GTP could be used as a phosphoryl donor in signal transduction and protein synthesis. Synonyms: GTP-Na2; Guanosine 5'-(tetrahydrogen triphosphate) sodium salt (1:2); Guanosine 5'-(tetrahydrogen triphosphate) disodium salt; 5'-GTP disodium salt; Disodium 5'-GTP; Disodium guanosine triphosphate; GTP disodium salt; Guanosine 5'-triphosphoric acid disodium salt. Grades: ≥90% by HPLC. CAS No. 56001-37-7. Molecular formula: C10H14N5Na2O14P3. Mole weight: 567.14.
Guanylyl-(3',5')-adenosine, a cyclic nucleotide second messenger, intricately orchestrates various cellular signaling pathways, rendering it crucial in regulating a myriad of physiological functions, ranging from neurotransmitter release to smooth muscle contraction. A versatile molecule of interest, this compound boasts promising potential in the therapeutic arena, especially for treating cardiovascular diseases, such as hypertension and heart failure, thanks to its adeptness in modulating platelet activation and gene expression. Synonyms: Guanine ribonucleotidyl-(3'-5')-adenosine; Adenylyl-(5',3')-guanosine; GpA RNA Dinucleotide (5'-3'). Grades: ≥95% by AX-HPLC. CAS No. 6554-00-3. Molecular formula: C20H25N10O11P. Mole weight: 612.40.
Guanylyl-3'-5'-adenosine triethylammonium salt
Guanylyl-3'-5'-adenosine triethylammonium salt is a versatile biomedical compound employed extensively within the pharmaceutical sector, emerging as a pivotal substrate for the esteemed guanylyl cyclase enzymes. This quintessential compound finds widespread utilization in an array of fundamental biochemical and pharmacological investigations, encompassing the study of cyclic GMP signaling cascade, neuropeptide release and the inducement of smooth muscle relaxation. Synonyms: GpA. Molecular formula: C20H25N10O11P·xC6H15N. Mole weight: 612.45 (free acid).
Guanylyl-3',5'-guanosine ammonium salt
Guanylyl-3',5'-guanosine ammonium salt is a vital reagent used in the biomedicine industry. It acts as a substrate in various enzymatic reactions involving guanylyltransferases, catalyzing the formation of mRNA caps. This product plays a crucial role in studying mRNA processing, capping, and gene expression. Additionally, it is used for investigating diseases related to mRNA capping abnormalities, such as cancer and viral infections. Synonyms: Guanosine, guanylyl-(3'?5')-, monoammonium salt; ((2R,3S,4R,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl ((2R,3S,4R,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl) hydrogen phosphate, monoammonium salt; 5'-O-[3'-Guanosyl (ammonium)phosphono]guanosine. CAS No. 97403-87-7. Molecular formula: C20H25N10O12P.H3N. Mole weight: 645.48.
H-Arg-Gly-Asp-Cys-OH, a fibronectin binding motif to cell adhesion molecules, inhibits platelet aggregation and fibrinogen binding. Synonyms: RGDC; H-RGDC-OH; L-arginyl-glycyl-L-alpha-aspartyl-L-cysteine; (6S,12S,15R)-1,6-diamino-12-(carboxymethyl)-1-imino-15-(mercaptomethyl)-7,10,13-trioxo-2,8,11,14-tetraazahexadecan-16-oic acid. Grades: 95%. CAS No. 109292-46-8. Molecular formula: C15H27N7O7S. Mole weight: 449.48.
H-Arg-Gly-Glu-Ser-OH
H-Arg-Gly-Glu-Ser-OH is a RGD-related peptide, which is a control of RGDS to inhibit the binding activity of fibrinogen and activated platelet. Synonyms: RGES; H-RGES-OH; L-arginyl-glycyl-L-alpha-glutamyl-L-serine; L-Serine, N-(N-(N-L-arginylglycyl)-L-alpha-glutamyl)-; rgespeptide. Grades: 95%. CAS No. 93674-97-6. Molecular formula: C16H29N7O8. Mole weight: 447.44.
H-Arg-Gly-Glu-Ser-OH.TFA
H-Arg-Gly-Glu-Ser-OH.TFA is a RGD-related peptide, which is a control of RGDS to inhibit the binding activity of fibrinogen and activated platelet. Synonyms: RGES.TFA; H-RGES-OH.TFA; L-arginyl-glycyl-L-alpha-glutamyl-L-serine trifluoroacetic acid. Grades: >98%. Molecular formula: C16H29N7O8.C2HF3O2. Mole weight: 561.47.
H-Arg(Me)-OH acetate salt
L-NMMA is the archetypal competitive NOS inhibitor of all three NOS isoforms. Synonyms: NG-Monomethyl-L-arginine acetate; L-NMMA acetate; Targinine acetate. Grades: ≥98% by HPLC. CAS No. 53308-83-1. Molecular formula: C7H16N4O2·C2H4O2. Mole weight: 248.28.
H-Asp-Asp-Asp-Asp-Asp-OH
H-Asp-Asp-Asp-Asp-Asp-OH is an intricate peptide derivative with immense promise in the expansive research of diseases such as cancer and neurological disorders. Synonyms: L-Aspartic acid, L-α-aspartyl-L-α-aspartyl-L-α-aspartyl-L-α-aspartyl-; DDDDD; H-DDDDD-OH. Grades: ≥95%. CAS No. 124219-00-7. Molecular formula: C20H27N5O16. Mole weight: 593.45.
HATU
HATU, a triazolopyridine dirivative, has been found to be a peptide coupling reagent and could be used in the formation of of Aurora A kinase inhibitors. Synonyms: HATU; 2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate; O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1H-1,2,3-Triazolo[4,5-b]pyridinium, 1-[bis(dimethylamino)methylene]-, 3-oxide, hexafluorophosphate(1-) (1:1); O-(7-Azabenzotriazol-1-yl)-N,N,N,N-tetramethyl uronium hexafluorophosphate; 1H-1,2,3-Triazolo[4,5-b]pyridinium, 1-[bis(dimethylamino)methylene]-, hexafluorophosphate(1-), 3-oxide; 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate. Grades: 98%. CAS No. 148893-10-1. Molecular formula: C10H15F6N6OP. Mole weight: 380.23.
HDMC is a reagent used in preparation of COMU as a more effective peptide coupling reagent than benzotriazole-based uronium compounds in peptide synthesis. Synonyms: HDMC; 6-HDMCB; (5-Chloro-3-oxo-1H-1lambda-5,2,3-benzotriazol-1-yl)-N,N-dimethyl(morpholin-4-yl)methaniminium hexafluorophosphate; SCHEMBL21223097; DTXSID00746375; BCP29166; N-[(5-Chloro-3-oxido-1H-benzotriazol-1-yl)-4-morpholinylmethylene]-N-methylmethanaminium hexafluorophosphate. Grades: > 95 % (HPLC). CAS No. 1082951-62-9. Molecular formula: C13H17ClF6N5O2P. Mole weight: 455.72.
Hemokinin 1 mouse
Hemokinin 1 (mouse) is a mammalian endogenous peptide and homolog of substance P. Hemokinin 1 (mouse) acts as a high affinity and selective agonist at the tachykinin NK1 receptor (Ki = 0.175 and 560 nM for NK1 and NK2 receptors, respectively). It induces proliferation of B-cells in vitro and exhibits antihypertensive activity in vivo. Synonyms: H-Arg-Ser-Arg-Thr-Arg-Gln-Phe-Tyr-Gly-Leu-Met-NH2; L-arginyl-L-seryl-L-arginyl-L-threonyl-L-arginyl-L-glutaminyl-L-phenylalanyl-L-tyrosyl-glycyl-L-leucyl-L-methioninamide; HK-1 (mouse, rat); HEK-1. Grades: ≥95%. CAS No. 208041-90-1. Molecular formula: C61H100N22O15S. Mole weight: 1413.65.
Hemorphin-7
Hemorphin-7, a hemorphin peptide with antinociceptive and antihypertensive effects, is an endogenous opioid peptide derived from the β-chain of hemoglobin. Hemorphin peptides activates opioid receptors and inhibiting angiotensin-converting enzyme (ACE). The much lower affinity of hemorphin- 7 for μ-receptors as compared to other opioid peptides may be compensated by its much higher plasma concentration, resulting in biological effects of comparable magnitude. Synonyms: H-Tyr-Pro-Trp-Thr-Gln-Arg-Phe-OH; L-tyrosyl-L-prolyl-L-tryptophyl-L-threonyl-L-glutaminyl-L-arginyl-L-phenylalanine; L-Phenylalanine, N-(N2-(N2-(N-(N-(1-L-tyrosyl-L-prolyl)-L-tryptophyl)-L-threonyl)-L-glutaminyl)-L-arginyl)-. Grades: ≥97%. CAS No. 152685-85-3. Molecular formula: C49H64N12O11. Mole weight: 997.11.
HEX-3
HEX3 is a fragment of the adenoviral hexon which is the major capsid protein found in Adenoviruses and is comprised of three identical polypeptide chains. Synonyms: HEX 3; HEX3; Lys-Tyr-Ser-Pro-Ser-Asn-Val-Lys-Ile; L-lysyl-L-tyrosyl-L-seryl-L-prolyl-L-seryl-L-asparaginyl-L-valyl-L-lysyl-L-isoleucine. Grades: ≥95%. CAS No. 688805-40-5. Molecular formula: C47H78N12O14. Mole weight: 1035.19.
Hexa-His
Hexa-His, consisting of 6 His residues in a row, called His-Tag, is used as a metal binding site for the recombinant protein. His-Tag sequence can be placed on the N- or -terminal of a target protein by using vectors from various commercial molecular biology companies. Synonyms: His Tag; Histidine hexapeptide; H-His-His-His-His-His-His-OH; L-histidyl-L-histidyl-L-histidyl-L-histidyl-L-histidyl-L-histidine; (2S,5S,8S,11S,14S,17S)-2,5,8,11,14-pentakis((1H-imidazol-4-yl)methyl)-17-amino-18-(1H-imidazol-4-yl)-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaoctadecan-1-oic acid. Grades: ≥95%. CAS No. 64134-30-1. Molecular formula: C36H44N18O7. Mole weight: 840.85.
HIV p17 Gag 77-85 is used in the research of anti-HIV. Synonyms: HIV-1 gag Protein p17 (76-84); H-Ser-Leu-Tyr-Asn-Thr-Val-Ala-Thr-Leu-OH; L-seryl-L-leucyl-L-tyrosyl-L-asparagyl-L-threonyl-L-valyl-L-alanyl-L-threonyl-L-leucine; HIV P17 GAG (77-85). Grades: ≥95%. CAS No. 147468-65-3. Molecular formula: C44H72N10O15. Mole weight: 981.10.
HMG-CoA
HMG-CoA is an intermediate in the mevalonate pathway. Synonyms: S-(Hydrogen 3-Hydroxy-3-methylglutarate) Coenzyme A; 3-Hydroxy-3-methylglutaryl CoA; 3-Hydroxy-3-methylglutaryl Coenzyme A; Hydroxymethylglutaryl CoA; Hydroxymethylglutaryl Coenzyme A; β-Hydroxy-β-methylglutaryl CoA; β-Hydroxy-β-methylglutaryl-coenzyme A. CAS No. 1553-55-5. Molecular formula: C27H44N7O20P3S. Mole weight: 911.66.
HOOBT
HOOBt is a STAT5-SUMO protein-protein interaction inhibitor that suppresses SUMOylation of phosphorylated STAT5. Synonyms: 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one; 3-hydroxy-3H-benzo[d][1,2,3]triazin-4-one; DHBT; oxohydroxybenzotriazole; 4-oxo-3,4-dihydro-3-hydroxy-1,2,3-benzotriazine; 3-Hydroxy-4-ketobenzotriazine; 3,4-Dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine; 1,2,3-Benzotriazin-4(3H)-one,3-hydroxy; 3,4-dihydro-3-hydroxy-4-keto-1,2,3-benzotriazine; 3-Hydroxy-3,4-dihydro-4-oxo-1,2,3-benzotriazine. Grades: 98% (HPLC). CAS No. 28230-32-2. Molecular formula: C7H5N3O2. Mole weight: 163.13.
A carnitine palmitoyltransferase-1 inhibitor. It has been shown to improve whole-body glucose tolerance and insulin sensitivity in high-fat diet-induced obese mouse with insulin resistance. Uses: Enzyme inhibitors. Synonyms: Oxfenicine; 4-Hydroxy-L-phenylglycine; L-4-Hydroxyphenylglycine; (2S)-2-amino-2-(4-hydroxyphenyl)acetic acid. Grades: ≥98%. CAS No. 32462-30-9. Molecular formula: C8H9NO3. Mole weight: 167.16.
Huwentoxin IV is a selective NaV1.7 channel blocker with preference for neuronal NaV1.7, 1.2 and 1.3 (IC50 = 26, 150 and 338 nM, respectively). Huwentoxin IV inhibits the channel via binding at the neurotoxin receptor site 4 in the S3-S4 linker of domain II, trapping the voltage sensor in the inward, closed configuration. Synonyms: HWTX-IV; H-Glu-Cys(1)-Leu-Glu-Ile-Phe-Lys-Ala-Cys(2)-Asn-Pro-Ser-Asn-Asp-Gln-Cys(3)-Cys(1)-Lys-Ser-Ser-Lys-Leu-Val-Cys(2)-Ser-Arg-Lys-Thr-Arg-Trp-Cys(3)-Lys-Tyr-Gln-Ile-NH2; L-alpha-glutamyl-L-cysteinyl-L-leucyl-L-alpha-glutamyl-L-isoleucyl-L-phenylalanyl-L-lysyl-L-alanyl-L-cysteinyl-L-asparagyl-L-prolyl-L-seryl-L-asparagyl-L-alpha-aspartyl-L-glutaminyl-L-cysteinyl-L-cysteinyl-L-lysyl-L-seryl-L-seryl-L-lysyl-L-leucyl-L-valyl-L-cysteinyl-L-seryl-L-arginyl-L-lysyl-L-threonyl-L-arginyl-L-tryptophyl-L-cysteinyl-L-lysyl-L-tyrosyl-L-glutaminyl-L-isoleucinamide (2->17),(9->24),(16->31)-tris(disulfide). Grades: >99%. CAS No. 526224-73-7. Molecular formula: C174H278N52O51S6. Mole weight: 4106.79.
Huwentoxin XVI
Huwentoxin XVI is a potent and selective N-type Ca2+ channel blocker (IC50 ~ 60 nM) with no inhibitory effect on T-type Ca2+ channels, K+ channels or Na+ channels. Huwentoxin XVI exhibits analgesic effects in vivo. Grades: >98%. CAS No. 1600543-88-1. Molecular formula: C196H292N50O56S6. Mole weight: 4437.13.
Icatibant
Icatibant(HOE-140) is a selective and specific antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: L-Arginine, D-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-(2S,3aS,7aS)-octahydro-1H-indole-2-carbonyl-; H-D-Arg-Arg-Pro-Hyp-Gly-2Thi-Ser-D-Tic-Oic-Arg-OH; D-Arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-(2S,3aS,7aS)-octahydro-1H-indole-2-carbonyl-L-arginine; HOE140; HOE 140; HOE-140. Grades: >98%. CAS No. 130308-48-4. Molecular formula: C59H89N19O13S. Mole weight: 1304.52.
ICI 154,129
ICI 154,129 is a selective δ opioid antagonist. It is a peptide analog that antagonized the effects of Leu-enkephalin. Uses: Narcotic antagonists. Synonyms: N,N-Di(2-propenyl)-L-Tyr-N-[2-[[(S)-2-[[(S)-1-carboxy-3-methylbutyl]amino]-2-oxo-1-benzylethyl]thio]ethyl]-Gly-NH2; M-154129. Grades: >98%. CAS No. 83420-94-4. Molecular formula: C34H46N4O6S. Mole weight: 638.83.
ICI 174,864
ICI 174,864 is a potent and highly selective δ opioid antagonist. It shows partial agonist in vitro activity at δ receptors at high concentrations. Synonyms: ICI 174,864; ICI174,864; ICI-174,864; N,N-Di-2-propen-1-yl-L-tyrosyl-2-methylalanyl-L-phenylalanyl-L-leucine; NIH 10893; N,N-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine; L-Leucine, N-(N-(N-(N,N-di-2-propenyl-L-tyrosyl)-2-methylalanyl)-L-phenylalanyl)-; N,N-Diallyl-Tyr-aib-Phe-Leu. Grades: >98%. CAS No. 89352-67-0. Molecular formula: C38H53N5O7. Mole weight: 691.87.
IGF-I 24-41
IGF-I 24-41 is a 24-41 amino acid fragment of insulin-like growth factor I(IGF-I). IGF-I has anabolic, antioxidant, anti-inflammatory and cell-protective properties. Synonyms: Insulin-like Growth Factor I (24-41); H-Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr-OH; L-tyrosyl-L-phenylalanyl-L-asparagyl-L-lysyl-L-prolyl-L-threonyl-glycyl-L-tyrosyl-glycyl-L-seryl-L-seryl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-prolyl-L-glutaminyl-L-threonine. Grades: ≥95%. CAS No. 135861-49-3. Molecular formula: C88H133N27O28. Mole weight: 2017.16.
IGF-I 30-41
IGF-I 30-41 is a 30-41 amino acid fragment of insulin-like growth factor I(IGF-I). IGF-I has anabolic, antioxidant, anti-inflammatory and cell-protective properties. Synonyms: Insulin-like Growth Factor I (30-41); H-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr-OH; glycyl-L-tyrosyl-glycyl-L-seryl-L-seryl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-prolyl-L-glutaminyl-L-threonine. Grades: ≥95%. CAS No. 82177-09-1. Molecular formula: C51H83N19O19. Mole weight: 1266.32.
Imidodicarbonic acid, 2-(2-fluoro-9H-purin-6-yl)-, 1,3-bis(1,1-dimethylethyl) ester is an extraordinary compound used for precisely targeting distinct molecular pathways linked to the research of diverse malignancies and autoimmune disorders. CAS No. 1365535-18-7. Molecular formula: C15H20FN5O4. Mole weight: 353.35.
Inarigivir
Inarigivir is a dinucleotide prodrug with antiviral and immunomodulatory activity, which has the potential for the treatment of HBV infections. Synonyms: ORI-9020; SB-9000. Grades: 99.20%. CAS No. 475650-36-3. Molecular formula: C20H26N7O10PS. Mole weight: 587.50.
Indoximod
A methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy. Synonyms: NLG8189; NLG 8189; NLG-8189; D-1MT; 1-methyl-D-tryptophan; H-D-Trp(Me)-OH. Grades: > 98%. CAS No. 110117-83-4. Molecular formula: C12H14N2O2. Mole weight: 218.25.
Inosine 2',3'-cyclic monophosphate sodium salt
Inosine 2',3'-cyclic monophosphate sodium salt is an indispensable compound extensively employed in the biomedical field, manifesting its significance through the research of diverse afflictions including cardiovascular dysfunctions, malignant tumors and neurodegenerative ailments. Functioning as a facilitator of signal transduction regulation, this product remarkably orchestrates cellular reactions. Synonyms: 2',3' cyclic IMP. CAS No. 15569-30-9. Molecular formula: C10H11N4O7P. Mole weight: 330.19.
Inosine-3',5'-cyclic-monophosphate triethylammonium is an indispensable compound extensively employed in the biomedical sector, operating as a pivotal second messenger in manifold cellular pathways. Its paramount significance lies in its indispensable role in studying signal transduction, gene expression and cellular metabolism, thereby facilitating research endeavors concerning drug development, particularly focused on cardiovascular, neurological and immune-related maladies. Molecular formula: C10H11N4O7P·NC6H15. Mole weight: 431.38.
Inosine-5'-monophosphate disodium salt heptahydrate
Inosine-5'-monophosphate disodium salt heptahydrate, an indispensable intermediate in purine biosynthesis, possesses a crucial role in nucleotide metabolism. Its applications primarily encompass functions such as treating gout and hyperuricemia while simultaneously enhancing the production of ribonucleotides. Synonyms: Sodium 5'-Inosinate hydrate (2:1:7). Grades: 98%. CAS No. 849725-39-9. Molecular formula: C10H25N4Na2O15P. Mole weight: 518.28.
Inosine 5'-triphosphate lithium salt
Inosine 5'-triphosphate lithium salt is a crucial element in the biomedical industry with antiviral properties. It plays a significant role in the research of various diseases, including viral infections and autoimmune disorders. Molecular formula: C10H15N4O14P3F. Mole weight: 527.16.
(-)-Inosine Dehydroxy-N-(6-iminohexyl)-2,2,2-trifluoroacetamide is an intermediate in synthesizing N6-(6-Aminohexyl)-FAD, a Flavine Adenine Dinucleotide (FAD) derivative. Attachment of a ligand to the 6-Aminohexyl side chain of this compound, can be used as a FAD-labelled conjugate to measure the concentration of the free ligand in a competitive binding immunoassay. Synonyms: N-(6-((9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)amino)hexyl)-2,2,2-trifluoroacetamide; N-[8-(Acetylamino)?octyl]?-adenosine Trifluoroacetamide. Molecular formula: C18H25F3N6O5. Mole weight: 462.42.
(-)-Inosine Dehydroxy-N-(6-iminohexyl)-2,2,2-trifluoroacetamide Phosphate is an intermediate in synthesizing N6-(6-Aminohexyl)-FAD, a Flavine Adenine Dinucleotide (FAD) derivative. Attachment of a ligand to the 6-Aminohexyl side chain of this compound, can be used as a FAD-labelled conjugate to measure the concentration of the free ligand in a competitive binding immunoassay. Synonyms: ((2R,3S,4R,5R)-3,4-Dihydroxy-5-(6-((6-(2,2,2-trifluoroacetamido)hexyl)amino)-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl Dihydrogen Phosphate. Molecular formula: C18H26F3N6O8P. Mole weight: 542.4.