BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| CRT0066854 | CRT0066854 is a selective and ATP-competitive inhibitor of the atypical PKC isoenzymes (IC50 values 639 nM and 132 nM for full-length PKCζ, PKCΙ, respectively). CRT0066854 decreases colony formation in HeLa cells, inhibits LLGL2 phosphorylation and polarized epithelial morphogenesis, and impedes directed migration of NRK cells. Synonyms: CRT0066854; CRT 0066854; CRT-0066854; (2S)-3-Phenyl-N1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-1,2-propanediamine. Grade: 99%. CAS No. 1438881-19-6. Molecular formula: C24H25N5S. Mole weight: 415.55. |  |
| CRT 0066854 hydrochloride | The hydrochloride salt form of CRT 0066854, which has been found to be a PKC inhibitor. Synonyms: CRT 0066854 hydrochloride; CRT0066854 hydrochloride; CRT-0066854 hydrochloride; (2S)-3-Phenyl-N1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-1,2-propanediamine dihydrochloride. Grade: ≥98% by HPLC. Molecular formula: C24H25N5S.2HCl. Mole weight: 488.48. | |
| CRT0066854 hydrochloride | CRT0066854 is against full-length (FL) PKCΙ, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively. Synonyms: CRT 0066854 hydrochloride. CAS No. 2250019-91-9. Molecular formula: C24H27Cl2N5S. Mole weight: 452.01. | |
| CRT 0105950 | CRT 0105950 is a potent inhibitor of LIMK1/2 (IC50 = 0.3 and 1 nM at LIMK 1 and 2, respectively). It disrupts microtubule organization, inhibits phosphorylation of cofilin and increases α-tubulin acetylation in vitro. Synonyms: 4-[[5-[3-(2-Chloro-4-methylphenyl)-4-pyridinyl]-2-thiazolyl]amino]phenol. Grade: ≥98% by HPLC. CAS No. 1661845-86-8. Molecular formula: C21H16ClN3OS. Mole weight: 393.89. | |
| CRT5 | CRT5 is a pyrazine benzamide that prevents activation of all three isoforms of PKD (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively) in endothelial cells treated with VEGF. Synonyms: CRT0066051. Grade: ≥98%. CAS No. 1034297-58-9. Molecular formula: C28H30N4O2. Mole weight: 454.6. | |
| CRTh2 antagonist 1 | CRTh2 antagonist 1 is a CRTh2 antagonist (IC50: 89 nM). CAS No. 1379445-54-1. Molecular formula: C23H25N3O5S. Mole weight: 455.53. | |
| CRTh2 antagonist 2 | CRTh2 antagonist 2 is a selective and potent CRTH2 antagonist with an IC50 of ≤10 nM. CRTh2 antagonist 2 can be used in research of androgenic alopecia. Synonyms: AP-768; (4-chloro-6-(dimethylamino)-2-[4-(2-naphthoylamino)benzyl]pyrimidin-5-yl}acetic acid. CAS No. 780763-95-3. Molecular formula: C26H23ClN4O3. Mole weight: 474.94. | |
| CRTh2 antagonist 3 | CRTh2 antagonist 3 is a potent chemokine receptor homologous molecule expressed on Th2 cell (CRTh2) antagonists. It enhances the activity of PDK1 toward a short peptide substrate, with an EC50 of 2 μM and a Kd of 8.4 μM. Synonyms: (2-{[2-(2,6-dimethylphenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid. CAS No. 312928-72-6. Molecular formula: C19H20N2O3S. Mole weight: 356.44. | |
| CRTH2-IN-1 | CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, with an IC50 of 6 nM in the human DP2 binding assay. Synonyms: (+/-) {7-[[(4-fluorophenyl)sulfonyl](methyl)amino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl}acetic acid; Ramatroban analog. CAS No. 926661-54-3. Molecular formula: C21H21FN2O4S. Mole weight: 416.47. | |
| Cruzain-IN-1 | Cruzain-IN-1 is a selective inhibitor of trypanosomal cysteine proteases and a reversible Cruzain inhibitor with IC50 of 10 nM. Synonyms: Cruzain-IN-1; 1199523-24-4; ML092; CHEMBL567341; MMV676881; 6-(3,5-difluoroanilino)-9-ethyl-2-purinecarbonitrile; 6-(3,5-difluoroanilino)-9-ethylpurine-2-carbonitrile; 6-[(3,5-difluorophenyl)amino]-9-ethyl-9H-purine-2-carbonitrile; 6-((3,5-Difluorophenyl)amino)-9-ethyl-9H-purine-2-carbonitrile; Cruzain-IN-1ML092; Cruzain-IN-1; ML-092; ML092 Cruzain-IN-1; MLS002471782; CHEBI:92430; DTXSID201347893; HMS2203P24; HMS3332L09; 6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-carbonitrile; BCP29960; ZXB52324; BDBM50303420; AKOS037515628; NCGC00181918-01; NCGC00181918-02; BS-14613; HY-10836; ML092; ML 092; ML-092; SMR001395197; CS-0002855; S0722; D80998; EN300-7501911; SR-01000860687; SR-01000860687-2; Q27164166; Z2941522289. Grade: 95%. CAS No. 1199523-24-4. Molecular formula: C14H10F2N6. Mole weight: 300.27. | |
| CS-003 Free base | CS-003 is a triple tachykinin receptor antagonist, showing high affinities for human (Neurokinin) NK1, NK2 and NK3 receptors with Ki values of 2.3 nM, 0.54 nM and 0.74 nM, respectively. CS-003 has therapeutic efficacy on respiratory diseases associated with neurokinins. CAS No. 191672-52-3. Molecular formula: C34H38Cl2N2O6S. Mole weight: 673.65. | |
| CS-0777-P | CS-0777 is a selective sphingosine 1-phosphate receptor modulator agonist. It is in clinical trials for the treatment of multiple sclerosis, but no recent development was reported. Uses: Multiple sclerosis. Synonyms: CS-0777; CS0777; CS 0777. 1-(5-((3R)-3-amino-3-methyl-4-(phosphonooxy)butyl)-1-methyl-1H-pyrrol-2-yl)-4-(4-methylphenyl)-1-Butanone. Grade: 98%. CAS No. 840523-39-9. Molecular formula: C21H31N2O5P. Mole weight: 422.45. | |
| CS1 | CS1 is a Topo IIα inhibitor with broad-spectrum in vitro antitumor activity. CS1 acts as a Topo II poison to stabilize Topo II/DNA complex causing DNA damage, cell cycle arrest at G2/M phase, and apoptosis. Uses: Antitumor agent. Synonyms: CS-1; CS 1; CS1; 4-(6-Hydroxy-2-naphthalenyl)-1,2-benzenediol. Grade: 99%. CAS No. 1448009-94-6. Molecular formula: C16H12O3. Mole weight: 252.26. | |
| CS 2100 | CS 2100 has been found to be a S1P1 agonist and exhibit activities in animal's adjuvant-induced arthritis model. Synonyms: CS-2100; CS 2100; CS2100. 1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid. Grade: ≥97% by HPLC. CAS No. 913827-99-3. Molecular formula: C25H23N3O4S. Mole weight: 461.53. | |
| CS 476 | AT-308 is a synthetic bio-active chemical as an oral hypoglycaemic agent. Uses: An oral hypoglycaemic agent. Synonyms: CS 476; CS-476; CS476; NOVO CS 476; NSC 302998. N-(4-(2-(2,3-Dihydrobenzo(b)furan-7-carboxamido)ethyl)benzenesulfonyl)-N'-cyclohexylurea. Grade: ≥98%. CAS No. 41177-35-9. Molecular formula: C24H29N3O5S. Mole weight: 471.57. | |
| CS-7017 monohydrate | CS-7017 monohydrate is a peroxisome proliferator activated receptor gamma (PPAR) agonist. It is a potential therapy for thyroid cancer and liposarcoma. It is also used for the treatment of rectal cancer and non-small cell lung cancer. It was developed by Daiichi Sankyo Company Limited. It is in clinic phase 2 with no progress. Uses: Cs-7017 monohydrate is a potential therapy for thyroid cancer and liposarcoma. it is also used for the treatment of rectal cancer and non-small cell lung cancer. Synonyms: CS-7017 monohydrate; CS 7017 monohydrate; CS7017 monohydrate; Efatutazone dihydrochloride monohydrate; 5-[[4-[[6-(4-Amino-3,5-dimethylphenoxy)-1-methylbenzimidazol-2-yl]methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione hydrate dihydrochloride; Inolitazone dihydrochloride monohydrate; (+/-)-2,4-Thiazolidinedione, 5-((4-((6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1H-benzimidazol-2-yl)methoxy)phenyl)methyl)-, dihydrochloride, monohydrate. Grade: >99 %. CAS No. 1048002-36-3. Molecular formula: C27H30Cl2N4O5S. Mole weight: 593.52. | |
| CS 722 | CS 722 is a neuromuscular blocking agent and centrally acting muscle relaxant. It exerts its muscle relaxant action by affecting both the supraspinal structure and the spinal cord. In Oct 2000, Phase II for Hypertonia in Japan was discontinued. Uses: Muscle hypertonia. Synonyms: CS 722; CS-722; CS722. 4-Chloro-2-(2-hydroxy-3-morpholinopropyl)-5-phenyl-4-isoxazolin-3-one. Grade: 98%. CAS No. 144886-17-9. Molecular formula: C16H20Cl2N2O4. Mole weight: 375.25. | |
| CS-834 | CS-834, a carbapenem derivative, has been found to be a cell wall inhibitor that was once studied as an antiibacterial agent by Sankyo. Synonyms: CS 834; CS834; CS-834; UNII-H26S03B779; [(2,2-dimethylpropanoyl)oxy]methyl (4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3-{[(3R)-5-oxopyrrolidin-3-yl]sulfanyl}-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate. Grade: 98%. CAS No. 157542-49-9. Molecular formula: C20H28N2O7S. Mole weight: 440.51. | |
| CSF1R-IN-1 | CSF1R-IN-1 is a CSF1R inhibitor with IC50 of 0.5 nM. Synonyms: CSF1R Inhibitor Compound 22; CHEMBL4084391; EX-A5045; HY-101774. Grade: 98%. CAS No. 2095849-04-8. Molecular formula: C25H20F3N5O2. Mole weight: 479.5. | |
| CS-M1995 | CS-M1995 is a 4'-Azidocytidine analogue. It can inhibit Hepatitis C virus replication. Uses: Cs-m1995 can inhibit hepatitis c virus replication. Synonyms: CS-M1995; CS M1995; CSM1995; Nucleoside-Analog-1; 6H-Furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one, 2-azido-2,3,3a,9a-tetrahydro-3-hydroxy-2-(hydroxymethyl)-, (2R,3S,3aS,9aR)-; (2R,3S,3aS,9aR)-2-azido-3-hydroxy-2-(hydroxymethyl)-3a,9a-dihydro-3H-furo[1,2][1,3]oxazolo[3,4-a]pyrimidin-6-one. Grade: >98 %. CAS No. 876707-99-2. Molecular formula: C9H9N5O5. Mole weight: 267.20. | |
| CS-M1996 | CS-M1996 is a 4'-Azidocytidine analogue. It can inhibit Hepatitis C virus replication. Uses: Cs-m1996 can inhibit hepatitis c virus replication. Synonyms: CS-M1996; CS M1996; CSM1996; 2,4(1H,3H)-PyriMidinedione, 1-(4-C-azido-β-D-arabinofuranosyl)- (9CI); Nucleoside-Analog-2; 1-[(2R,3S,4S,5R)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione. Grade: >98 %. CAS No. 876708-01-9. Molecular formula: C9H11N5O6. Mole weight: 285.21. | |
| CSRM617 | CSRM617 is an inhibitor of the transcription factor ONECUT2 (OC2), thereby suppressing metastasis in mice. CSRM617 induces apoptosis by appearance of cleaved Caspase-3 and PARP. Synonyms: (2RS)-2-Amino-3-hydroxy-N'-[(EZ)-(2,3,4-trihydroxyphenyl)methylidene]propanehydrazide; Benserazide hydrochloride EP Impurity C. CAS No. 787504-88-5. Molecular formula: C10H13N3O5. Mole weight: 255.23. | |
| CT-1 | CT-1 is a novel orally active DNA minor groove ligand and causes p53-dependent breast cancer cell apoptosis. Synonyms: 3,5-Bis-(2-fluoro-benzylidene)-1-[1-(4-fluoro-benzyl)-1H-[1,2,3]triazol-4-ylmethyl]-piperidin-4-one. CAS No. 1983924-33-9. Molecular formula: C29H23F3N4O. Mole weight: 500.51. | |
| CT7001 hydrochloride | CT7001, also known as ICEC0942, is an orally bioavailable CDK7 inhibitor with IC50 value of 40nM. CDK7 phosphorylates the C-terminal domain (CTD) of RNA polymerase II (PolII) to enable transcription initiation, and also affects some transcriptional factor activities, resulting in suppression of types of cancers. Synonyms: ICEC0942 hydrochloride; (3R,4R)-4-[[[7-(benzylamino)-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol hydrochloride. CAS No. 1805789-54-1. Molecular formula: C22H31ClN6O. Mole weight: 430.97. | |
| CT-721 | CT-721 is a potent and time-dependent inhibitor of Bcr-Abl kinase with an IC50 of 21.3 nM for wild-type Bcr-Abl kinase, and has anti-chronic myeloid leukemia (CML) activity. Synonyms: (1S)-N-{3-[(6-Chloroimidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methylphenyl}-1-(4-methyl-1-piperazinyl)-5-indanecarboxamide; 1H-Indene-5-carboxamide, N-[3-[2-(6-chloroimidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methylphenyl]-2,3-dihydro-1-(4-methyl-1-piperazinyl)-, (1S)-. Grade: ≥98%. CAS No. 1388710-60-8. Molecular formula: C30H29ClN6O. Mole weight: 525.04. | |
| CTA056 | CTA056 is a potent and selective ITK inhibitor (interleukin-2-inducible T-cell kinase inhibitor). ITK is a member of the Btk (Bruton's tyrosine kinase) family of tyrosine kinases, plays an important role in normal T-cell functions and in the pathophysiology of both autoimmune diseases and T-cell malignancies. CTA056 exhibits the highest inhibitory effects toward Itk, followed by Btk and endothelial and epithelial tyrosine kinase. Among the 41 cancer cell lines analyzed, CTA056 selectively targets acute lymphoblastic T-cell leukemia and cutaneous T-cell lymphoma. CTA056 may be potential therapeutic agent for the treatment of T-cell leukemia and lymphoma. Synonyms: CTA-056; CTA 056; 1,5-Dihydro-7-(phenylmethyl)-1-[3-(1-piperidinyl)propyl]-2-[4-(4-pyridinyl)phenyl]-6H-imidazo[4,5-g]quinoxalin-6-one. Grade: 98%. CAS No. 1265822-30-7. Molecular formula: C35H34N6O. Mole weight: 554.69. | |
| CTB | CTB is a p300 histone acetyltransferase activator. Synonyms: CTPB; N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide. CAS No. 451491-47-7. Molecular formula: C16H13ClF3NO2. Mole weight: 343.73. | |
| CTEP | CTEP is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor (IC50=2.2 nM), showing >1000-fold selectivity over other mGlu receptors. Synonyms: RO4956371; RO-4956371; RO 4956371; CTEP. Grade: >98%. CAS No. 871362-31-1. Molecular formula: C19H13ClF3N3O. Mole weight: 391.77. | |
| CTK8A3536 | CTK8A3536 is an androgen receptor inhibitor. Synonyms: 5-Thiazolemethanol, 2-(4-morpholinyl)-4-phenyl-; 2-(4-Morpholinyl)-4-phenyl-5-thiazolemethanol; [2-(Morpholin-4-yl)-4-phenyl-1,3-thiazol-5-yl]methanol; (2-morpholino-4-phenylthiazol-5-yl)methanol; Androgen receptor-IN-3; CTK-8A3536, CTK 8A3536. Grade: ≥95%. CAS No. 926228-58-2. Molecular formula: C14H16N2O2S. Mole weight: 276.35. | |
| CTLA-4 inhibitor | CTLA-4 inhibitor is an inhibitor of CTLA-4, an immune checkpoint negatively regulating T cell function. CTLA-4 is thought to regulate T-cell proliferation early in an immune response, primarily in lymph nodes. Synonyms: MDK24720; MDK 24720; MDK-24720; CTLA-4 inhibitor. 2-(4-Fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one; EX-A913. CAS No. 635324-72-0. Molecular formula: C21H13F4N5O. Mole weight: 427.363. | |
| cTMP | cTMP (2?,3?-dideoxy-3?-thiothymidine) is an exceptional biomedical compound ubiquitously applied in studying the pernicious Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS). Functioning as a high-potency antiretroviral compound, cTMP exercises its efficacious mechanism by adeptly obstructing the pernicious reverse transcriptase enzyme. Synonyms: Thymidine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 98% by HPLC. CAS No. 76567-90-3. Molecular formula: C10H12N2O7P · Na. Mole weight: 326.2. | |
| CTOP trifluoroacetate salt | CTOP is a peptide that acts as a selective antagonist of the μ-opioid receptor (IC50 = 2.8 nM). CTOP inhibits the antinociceptive effect of morphine in the tail flick test in mice (ED50 = 0.018 nmol) and reverses morphine-induced increases in locomotor activity (ED50 = 0.02 nmol). Synonyms: Phe-Cys-Tyr-Trp-Orn-Thr-Pen-Thr; D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-ornithyl-L-threonyl-3-mercapto-L-valyl-L-threoninamide-cyclic (2→7)-disulfide trifluoroacetate salt. Grade: ≥98%. Molecular formula: C50H67N11O11S2·xCF3COOH. Mole weight: 1062.3 (free base). | |
| CTP, 100mM Sodium Solution | The solution form of CTP. CTP is a P2X purinergic receptor agonist that can be used in the synthesis of RNA. In metabolic reactions, it acts as a coenzyme. Synonyms: Cytidine 5'-triphosphate, Sodium salt. Grade: ≥ 99% by HPLC. Molecular formula: C9H16N3O14P3 (free acid). Mole weight: 483.16 (free acid). | |
| CTP-347 | CTP-347 is a labelled analogue of Paroxetine. CTP-347 was developed for the treatment of hot flashes yet the phase I clinical trial was halted in 2013. Synonyms: Paroxetine-d2. CAS No. 923932-43-8. Molecular formula: C19H18D2FNO3. Mole weight: 331.38. | |
| CTPαS TEA salt | CTPαS, a molecule activator of soluble guanylate cyclase (sGC), is vying for a preeminent position in the study of nitric oxide signaling pathway. With its therapeutic potential locked and loaded, CTPαS is turning heads in the scientific community, demonstrating potential efficacy in addressing cardiovascular diseases such as hypertension and pulmonary arterial hypertension, as well as a wide range of central nervous system conditions, including neurodegenerative diseases and pain management alike. Synonyms: Cytidine, 5'→P''-ester with thiotriphosphoric acid TEA salt; Cytidine-5'-O-(1-thiotriphosphate) TEA salt; CTP-αS TEA salt; Cytidine-5'-(α-thio)-triphosphate, TEA salt (1:1 Mixture of Rp and Sp isomers). Grade: ≥95% by HPLC. Molecular formula: C9H16N3O13P3S (free acid). Mole weight: 499.21 (free acid). | |
| CTPB | CTPB is an amide derivative that acts as a selectively activator of the histone acetyltransferase (HAT) p300, with maximal activation at 275 μM. Synonyms: N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy-6-pentadecyl-benzamide. Grade: ≥98%. CAS No. 586976-24-1. Molecular formula: C31H43ClF3NO2. Mole weight: 554.1. | |
| CTP disodium dihydrate | CTP disodium dihydrate is a P2X4 purinergic receptor agonist. Synonyms: Cytidine 5-triphosphate disodium solution; Cytidine-5'-triphosphate disodium salt dihydrate; CTP disodium salt dihydrate; Cytidine 5'-(tetrahydrogen triphosphate), sodium salt, hydrate (1:2:2); Cytidine 5'-(tetrahydrogen triphosphate), disodium salt, dihydrate; 5'-CTP disodium dihydrate; Cytidine triphosphate disodium dihydrate. Grade: 95%. CAS No. 81012-87-5. Molecular formula: C9H18N3Na2O16P3. Mole weight: 563.15. | |
| CTP-γ-AmNS | CTP-γ-AmNS is a fluorescent analogue of CTP that is used for the determination of enzymes specialized to cleave α/β-phosphodiester bonds. Synonyms: Cytidine- 5'- O- triphosphoro- γ- 1- (5- sulfonic acid)naphthylamidate, sodium salt. Grade: ≥ 95% by HPLC. CAS No. 84230-52-4. Molecular formula: C19H23N4O16P3S (free acid). Mole weight: 688.4 (free acid). | |
| CTPI-2 | CTPI-2 is the third-generation mitochondrial citrate carrier SLC25A1 inhibitor with a KD of 3.5 μM. Synonyms: SLC25A1 Inhibitor CTPI-2; Benzoic Acid, 2-[[(4-Chloro-3-Nitrophenyl)Sulfonyl]Amino]-; 2-[(4-Chloro-3-Nitrophenyl)Sulphonyl]Anthranilic Acid. Grade: 98%. CAS No. 68003-38-3. Molecular formula: C13H9ClN2O6S. Mole weight: 356.74. | |
| CTP - lyophilized | The lyophilized form of CTP. CTP is a P2X purinergic receptor agonist that can be used in the synthesis of RNA. In metabolic reactions, it acts as a coenzyme. Synonyms: Cytidine 5'-triphosphate, Disodium salt trihydrate. Grade: ≥ 95% by HPLC. Molecular formula: C9H14N3Na2O14P3* 3H2O. Mole weight: 581.16. | |
| CTS-1027 | CTS-1027 inhibits individual members of the MMP family that are believed to be important in inflammation and tissue damage. CTS-1027 was specifically designed, however, not to inhibit MMP 1, as inhibition of MMP 1 was believed to be associated with musculoskeletal side effects. Synonyms: RS 130830; Ro 1130830; CTS1027; CTS 1027; RS130830; Ro1130830; RS-130830; Ro-1130830. Grade: >98%. CAS No. 193022-04-7. Molecular formula: C19H20ClNO6S. Mole weight: 425.88. | |
| CTS-21166 | CTS-21166, the selective BACE1 inhibitor whose structure is not revealed, reduce brain Aβ levels by over 35% and plaque load by 40%. Phase 1 IC50=1.2-3.6 nM (cell line details NA) APP transgenic mice, 4mg/kg i.p. injection for 6 weeks, >35% ↓ brain Aβ, 40% ↓ plaque load. Human patients, 7.5.225 mg i.v. injection dose-dependant ↓ plasma Aβ, 80% ↓ at 225 mg. Synonyms: ATG-Z1; CTS-21166; ZPQ-21166; ATG Z1; CTS 21166; ZPQ 21166; ATGZ1; CTS21166; ZPQ21166. Molecular formula: none. | |
| CTX-0294885 | CTX-0294885 is a novel broad-spectrum kinase inhibitor. CTx-0294885 exhibits inhibitory activity against a broad range of kinases in vitro. Use of a quantitative proteomics approach confirmed the selectivity of CTx-0294885-bound beads for kinase enrichment. Large-scale CTx-0294885-based affinity purification followed by LC-MS/MS led to the identification of 235 protein kinases from MDA-MB-231 cells, including all members of the AKT family that had not been previously detected by other broad-spectrum kinase inhibitors. CTx-0294885 represents a powerful new reagent for analysis of kinome signaling networks that may facilitate development of targeted therapeutic strategies. Synonyms: CTX 0294885; CTX0294885; Benzamide, 2-[[5-chloro-2-[[4-(1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methyl-. Grade: 98%. CAS No. 1439934-41-4. Molecular formula: C22H24ClN7O. Mole weight: 437.93. | |
| CTX-0294885 hydrochloride | CTX-0294885 hydrochloride is the hydrochloride salt of CTX-0294885 which displays high affinity toward an extensive range of kinases. The evaluation of the binding profile of CTx-0294885 in MDA-MB-231 cells by quantitative MS demonstrated its selective properties as a kinase enrichment reagent. Synonyms: 2-[[5-chloro-2-(4-piperazin-1-ylanilino)pyrimidin-4-yl]amino]-N-methylbenzamide; hydrochloride; CTX-0294885 hydrochloride; CTX 0294885 hydrochloride; CTX0294885 hydrochloride. Molecular formula: C22H25Cl2N7O. Mole weight: 474.39. | |
| C-Type Natriuretic Peptide-22 (human, porcine, rat) trifluoroacetate salt | C-Type natriuretic peptide-22 is an endogenous peptide which has diverse biological activities. CNP-22 acts as a selective agonist of natriuretic peptide receptors (NPRs) 2 and 3 (Kds = 7, 10.8, and >500,000 pM for NPR2, 3, and 1, respectively). The 22 amino acid sequence corresponds to residues 105-126 of its precursors prepro CNP, pro CNP, and CNP-53. Synonyms: CNP-22; glycyl-L-leucyl-L-seryl-L-lysylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-leucyl-L-lysyl-L-leucyl-L-α-aspartyl-L-arginyl-L-isoleucylglycyl-L-seryl-L-methionyl-L-serylglycyl-L-leucylglycyl-L-cysteine cyclic (6→22)-disulfide trifluoroacetate salt. Grade: ≥95%. Molecular formula: C93H157N27O28S3·xCF3COOH. Mole weight: 2197.60. | |
| CU-115 | CU-115 is a selective TLR8 inhibitor with IC50 of 1.04 μM. CU-115 was demonstrated that inhibits ssRNA-sensing pathways at low concentrations and does not inhibit other non-endosomal TLR and cytosolic NA-sensing pathways (<5 μ M). Synonyms: N-(4-(3,5-Bis(trifluoromethyl)phenoxy)phenyl)-2-fluoro-6-iodobenzamide. Grade: 98%. CAS No. 2471982-20-2. Molecular formula: C21H11F7INO2. Mole weight: 569.21. | |
| CU-32 | CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (IC50 = 0.45 μM). Synonyms: methyl 4-amino-6-((4-iodophenyl)amino)-1,3,5-triazine-2-carboxylate. Grade: 95%. CAS No. 2400954-16-5. Molecular formula: C11H10IN5O2. Mole weight: 371.13. | |
| CU-76 | An inhibitor of cyclic GMP-AMP synthase (IC50 = 0.24 μM). Synonyms: Methyl 4-amino-6-((3,5-difluoro-4-iodophenyl)amino)-1,3,5-triazine-2-carboxylate. Grade: 95%. CAS No. 2400954-58-5. Molecular formula: C11H8F2IN5O2. Mole weight: 407.11. | |
| CuATSM | CuATSM is a highly potent radical-trapping antioxidant (RTA) and (phosphorus)lipid peroxidation inhibitor, thereby accounting for its ability to inhibit ferroptosis. It is preclinically used as a potential therapy for ALS (amyotrophic lateral sclerosis) and a potential anti-Alzheimer's agent. Synonyms: Cu(II)astm; Copper(II) diacetyl-di(N4-methyl)thiosemicarbazone; [[2,2'-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]]copper; [[2,2'-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]](2-)-N2,N2',S,S']-, (SP-4-2)Copper; [[2,2-Prime-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]]copper; (SP-4-2)-[[2,2'-(1,2-dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato-κN2,κS]](2-)]-copper; copper-ATSM. Grade: ≥95%. CAS No. 68341-09-3. Molecular formula: C8H14CuN6S2. Mole weight: 321.91. | |
| CU-CPD107 | CU-CPD107 is a a tetrasubstituted imidazole that inhibits R848-induced TLR8 signaling. In the presence of R848, CU-CPD107 acts as a TLR8 signaling inhibitor with IC50 of 13.7 μM. Synonyms: GD0. CAS No. 2573912-32-8. Molecular formula: C16H21IN2O2. Mole weight: 400.26. | |
| CU CPT 22 | CU CPT 22 is a selective TLR1/2 inhibitor (IC50 = 0.58 μM). Synonyms: CU-CPT22; CU-CPT 22; CU-CPT-22; CUCPT22; CUCPT 22; CUCPT-22; 3,4,6-Trihydroxy-2-methoxy-5-oxo-5H-benzocycloheptene-8-carboxylic acid hexyl ester. CAS No. 1416324-85-0. Molecular formula: C19H22O7. Mole weight: 362.37. | |
| CU CPT 4a | CU CPT 4a is a selective TLR3 inhibitor (IC50 = 3.44 μM in RAW 264.7 cells). Synonyms: CU CPT 4a; CU-CPT-4a; CUCPT4a; N-[(3-Chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-D-phenylalanine. CAS No. 1279713-77-7. Molecular formula: C18H13ClFNO3S. Mole weight: 377.82. | |
| CU-CPT-8m | CU-CPT-9m is a TLR8 antagonist with an IC50 of 67 nM. Synonyms: CU-CPT-8m, CU-CPT 8m, CU-CPT8m; 7-(m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide; 7-(3-methylphenyl) pyrazolo(1,5-a)pyrimidine-3-carboxamide; 7-(3-methylphenyl) pyrazolo[1,5-a]pyrimidine-3-carboxamide; CU-CPT8m. CAS No. 125079-83-6. Molecular formula: C14H12N4O. Mole weight: 252.277. | |
| CU-CPT-9a | CU-CPT-9a is a TLR8 antagonist with an IC50 of 0.5 nM. Synonyms: CU-CPT9b; CUCPT9b; CU CPT9b; HY-112667; CS-0059157; HY 112667; CS 0059157; HY112667; CS0059157; 4-(3-methyl-4-oxidanyl-phenyl)quinolin-7-ol; 2-Methyl-4-(7-hydroxyl-4-quinolinyl)-phenol. CAS No. 2162962-69-6. Molecular formula: C16H13NO2. Mole weight: 251.285. | |
| CU-CPT-9b | CU-CPT-9b is a TLR8 inhibitor that inhibits TLR8-mediated proinflammatory signaling in various cell lines and human primary cells. Synonyms: CU-CPT9a; 2-Methyl-4-(7-methoxy-4-quinolinyl)phenol; CU CPT 9a; BCP29122; BCP-29122; CUCPT9a; BCP 29122; 4-(7-methoxy-1H-quinolin-4-ylidene)-2-methylcyclohexa-2,5-dien-1-one; Phenol, 4-(7-methoxy-4-quinolinyl)-2-methyl-; 4-(7-Methoxy-4-quinolinyl)-2-methylphenol. Grade: ≥95%. CAS No. 2165340-32-7. Molecular formula: C17H15NO2. Mole weight: 265.31. | |
| CUDA | CUDA is an inhibitor of soluble epoxide hydrolase (sEH) which catalyzes the conversion of EETs to the corresponding dihydroxy eicosatrienoic acids (DiHETrEs; DHETs) thereby diminishing their activity with IC50 values of 11.1 nM and 112 nM for the mouse and human enzymes, respectively. Synonyms: 12-[[(cyclohexylamino)carbonyl]amino]-dodecanoic acid. Grade: ≥95%. CAS No. 479413-68-8. Molecular formula: C19H36N2O3. Mole weight: 340.5. | |
| CUDC-101 | CUDC-101 is a multi-targeted, small-molecule inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor tyrosine kinase (EGFR/ErbB1), and human epidermal growth factor receptor 2 tyrosine kinase (HER2/neu or ErbB2) with potential antineoplastic activity. HDAC/EGFR/HER2 inhibitor CUDC-101 inhibits the activity of these three enzymes but the exact mechanism of action is presently unknown. This agent may help overcome resistance to inhibition of EGFR and Her2 through a simultaneous, synergistic inhibition of EGFR, Her2, and HDAC. Synonyms: CUDC101; CUDC 101; CUDC-101. CAS No. 1012054-59-9. Molecular formula: C24H26N4O4. Mole weight: 434.496. | |
| CUDC-907 | CUDC-907 is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, CUDC-907 inhibits the activity of both PI3K class I isoforms and HDAC, thereby preventing the activation of the PI3K-AKT-mTOR signal transduction pathway that is often overactivated in many cancer cell types. This may prevent growth of PI3K and/or HDAC-expressing tumor cells. CUDC-907 shows an increased inhibition of tumor cell growth and induction of apoptosis when compared to inhibitors that target either PI3K or HDAC. Synonyms: CUDC907; CUDC 907; CUDC-907. CAS No. 1339928-25-4. Molecular formula: C23H24N8O4S. Mole weight: 508.557. | |
| cUMP | cUMP is an analog of cyclic uridine monophosphate, showcasing its proficiency as a robust stimulator of soluble guanylate cyclase (sGC). With its implementation in biomedical research, an extensive exploration of sGC's involvement in diverse ailments such as cancer, cardiovascular disorders and neurodegenerative diseases is facilitated. Synonyms: Uridine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 98% by HPLC. CAS No. 56632-58-7. Molecular formula: C9H10N2O8P · Na. Mole weight: 328.2. | |
| cUMP-AM | cUMP-AM is a membrane-permeant and metabolically activatable prodrug of cUMP, the potential further second messenger. cUMP is released after permeation and metabolism by esterases, which is trapped inside the cell and metabolized to result in a pulse-type signal. Synonyms: Uridine- 3', 5'- cyclic monophosphate, acetoxymethyl ester. Grade: ≥ 95% by HPLC for mixtures of isomers. Molecular formula: C12H15N2O10P. Mole weight: 378.2. | |
| Cumyluron | Cumyluron, a urea analogue, is commonly used as a herbicide to control weeds in rice crops. Synonyms: 1-(2-Chlorobenzyl)-3-(2-phenylpropan-2-yl)urea; 1-(2-Chlorobenzyl)-3-(2-phenyl-2-propanyl)urea; 1-(2-Chlorobenzyl)-3-(α,α-dimethylbenzyl)urea; Urea, N-[(2-chlorophenyl)methyl]-N'-(1-methyl-1-phenylethyl)-; 1-(2-chlorobenzyl)-3-(1-methyl-1-phenylethyl)urea; 3-[(2-chlorophenyl)methyl]-1-(1-methyl-1-phenylethyl)urea. Grade: ≥95%. CAS No. 99485-76-4. Molecular formula: C17H19ClN2O. Mole weight: 302.80. | |
| CUR 61414 | CUR 61414 inhibits the activity of hedgehog-induced cellular (IC50 = 100-200 nM). It binds directly with the pathway activator Smoothened (Ki = 44 nM). Synonyms: G-856; N-[(3S,5S)-1-(1,3-benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethyl-butanamide. Grade: ≥98%. CAS No. 334998-36-6. Molecular formula: C31H42N4O5. Mole weight: 550.7. | |
| Curcumin β-D-Glucuronide | Curcumin β-D-Glucuronide is a metabolite of Curcumin in hepatic tissue and portal blood. Synonyms: 4-[(1E,6E)-7-(4-Hydroxy-3-methoxyphenyl)-3,5-dioxo-1,6-heptadien-1-yl]-2-methoxyphenyl β-D-glucopyranosiduronic acid; Curcumin glucuronide. Grade: >95%. CAS No. 227466-72-0. Molecular formula: C27H28O12. Mole weight: 544.51. | |
| Curcumin Sulfate | Curcumin Sulfate is a distinctive compound formulation extensively employed in the research of diverse pathological conditions, encompassing malignancies, inflammatory states and neurodegenerative perturbations. Curcumin is an indigenous bioactive constituent sourced from the rhizomes of Curcuma longa manifesting remarkable antioxidant activities and profound anti-inflammatory attributes. Synonyms: Curcumin sulfate; Curcumin sulphate; Curcumin monosulfate; 339286-19-0; UNII-160DHE331M; 160DHE331M; Curcumin Sulfate Sodium Salt; 1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(3-methoxy-4-(sulfooxy)phenyl)-, (1E,6E)-; 4-((1E,4Z,6E)-5-Hydroxy-7-(4-hydroxy-3-methoxyphenyl)-3-oxohepta-1,4,6-trien-1-yl)-2-methoxyphenyl hydrogen sulfate; SCHEMBL290796; DTXSID10893526; CHEBI:189746; DB14635; Q27251759; [4-[(1E,6E)-7-(4-hydroxy-3-methoxyphenyl)-3,5-dioxohepta-1,6-dienyl]-2-methoxyphenyl] hydrogen sulate; [4-[(1E,6E)-7-(4-hydroxy-3-methoxyphenyl)-3,5-dioxohepta-1,6-dienyl]-2-methoxyphenyl] hydrogen sulfate. Grade: > 95%. CAS No. 339286-19-0. Molecular formula: C37H55NO9S. Mole weight: 689.9. | |
| Curdlan | It is a microbial polysaccharide produced by a mutant strain of Alcaligenes faecalis var. myxogenes that was first shown to produce succinoglucan prior to mutation. Curdlan is a β(1-3) glucan which forms clear solutions at about 55°C and then forms ''low-set'' gels when cooled. Suspensions of curdlan at higher temperatures form firm resilient gels, ''high set'' gels, that melt at 140-160°C. Synonyms: β-1,3-Glucan; Curdlan from Alcaligenes faecalis; Biopoly P; Biopoly P 103; Curdlan CD-ES; Curdlan NS; Curdran; Beta-1,3-glucan from Alcaligenes faecalis. CAS No. 54724-00-4. Molecular formula: (C6H10O5)x. | |
| Curvulin | Curvulin is a phytotoxin that is first isolated from several species of the mold Curvularia. Curvulin inhibits microtubule assembly and has also been proved to inhibit iNOS expression. Synonyms: 2-acetyl-3,5-dihydroxy-benzeneacetic acid ethyl ester. Grade: ≥98%. CAS No. 19054-27-4. Molecular formula: C12H14O5. Mole weight: 238.2. | |
| Cusatuzumab | Cusatuzumab is a humanized anti-CD70 monoclonal antibody. Cusatuzumab was shown to eliminate leukemia stem cells (LSCs) in vitro and in xenotransplantation experiments, which triggers gene signatures related to myeloid differentiation and apoptosis. CAS No. 1864871-20-4. | |
| Cuspin-1 | Cuspin-1 is an upregulator of the Survival of Motor Neuron protein (SMN; EC50 value 18 μM in SMA patient fibroblast cells). Increased phosphorylation of ERK initiates Ras-Raf-MEK signaling, upregulating SMN protein levels in spinal muscular atrophy (SMA) patient fibroblasts. Synonyms: 3-bromo-5-(4-methylbenzoyl)pyridine; (5-bromopyridin-3-yl)-(4-methylphenyl)methanone. Grade: 99%. CAS No. 337932-29-3. Molecular formula: C13H10BrNO. Mole weight: 276.13. | |
| CU-T12-9 | CU-T12-9 is a potent small-molecule agonist of TLR1/2 (EC50 = 52.9 nM). Synonyms: Benzenamine, N-methyl-4-nitro-2-[4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-; CU T12 9; CUT129; N-Methyl-4-nitro-2-[4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]benzenamine; CU-T 12-9. Grade: ≥95%. CAS No. 1821387-73-8. Molecular formula: C17H13F3N4O2. Mole weight: 362.31. | |
| Cutamesine | Cutamesine, also called as SA4503, is an agonist, small-molecule ligand for the sigma-1 receptor with high selectivity currently in development to mediate neuroprotection and regeneration in the context of neurodegenerative disease. in vitro: reduced SOD1. Uses: Nootropic agents. Synonyms: 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine (11C)SA4503 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride cutamesine SA 4503 SA-4503 SA4503. CAS No. 165377-43-5. Molecular formula: C23H32N2O2. Mole weight: 368.51. | |
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