BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| CP 99994 dihydrochloride | The hydrochloride salt form of CP 99994, which is a high affinity NK1 antagonist and could attenuate endothelium-dependent contraction induced by substance P. Synonyms: CP 99994 dihydrochloride; CP99994 dihydrochloride; CP-99994 dihydrochloride; (2S,3S)-N-[(2-Methoxyphenyl)methyl]-2-phenyl-3-piperidinamine dihydrochloride. Grade: ≥99% by HPLC. CAS No. 145148-39-6. Molecular formula: C19H24N2O.2HCl. Mole weight: 369.33. |  |
| CPA inhibitor | CPA inhibitor is a potent inhibitor for carboxypeptidase A (CPA). Synonyms: carboxypeptidase inhibitor; Benzenepropanoic acid. alpha.-[[hydroxy(2-phenylacetyl)amino]methyl]-. Grade: >98%. CAS No. 223532-02-3. Molecular formula: C18H19NO4. Mole weight: 313.35. | |
| CPCCOEt | CPCCOEt has been found to be a mGluR-1 antagonist. Synonyms: 7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester. Grade: ≥99% by HPLC. CAS No. 179067-99-3. Molecular formula: C13H13NO4. Mole weight: 247.25. | |
| CpCpp | CpCpp is a compound used in studying a diverse array of malignant neoplasms, intricate neurological impairments and intractable autoimmune maladies. Synonyms: (CMPCPP); Cytidine-5'-[(α,β)-methyleno]triphosphate, Sodium salt. Grade: ≥ 95% by HPLC. CAS No. 101553-55-3. Molecular formula: C10H18N3O13P3 (free acid). Mole weight: 481.18 (free acid). | |
| CPDA | CPDA, a 4-substituted 2-pyridin-2-ylamide, has potential to inhibit SHIP2 which was found to enhance insulin signaling through the Akt pathway in viro and greatly improved abnormal glucose metabolism in diabetic animals. Synonyms: N-[4-[(4-chlorophenyl)methoxy]pyridin-2-yl]-2-(2,6-difluorophenyl)acetamide CPDA CHEMBL2337808 SCHEMBL14156872 AKOS027447209 CS-4991 AK517293 HY-18685 N-[4-(4-Chlorobenzyloxy)-2-pyridyl]-2,6-difluorobenzeneacetamide N-(4-((4-Chlorobenzyl)oxy)pyridin-2-yl). CAS No. 1415834-63-7. Molecular formula: C20H15ClF2N2O2. Mole weight: 388.79. | |
| CpdD hydrochloride | CpdD hydrochloride is a selective ghrelin receptor (GhrR aka GHSR-1a) antagonist. Synonyms: N-[(1R)-1-[3-[(4-bromophenyl)methyl]-1,2,4-oxadiazol-5-yl]-3-phenylpropyl]-3-(diethylamino)propane-1-sulfonamide hydrochloride. Grade: 99%. Molecular formula: C25H33BrN4O3S.HCl. Mole weight: 585.98. | |
| cPEPCK inhibitor | cPEPCK inhibitor is the first GTP-competitive inhibitor of human cytosolic phosphoenolpyruvate carboxykinase (PEPCK or cPEPCK). Synonyms: N-[4-[1-(2-Fluorobenzyl)-3-butyl-2,6-dixo-2,3,6,7-tetrahydro-1H-purin-8-ylmethyl]phenyl]acetamide. Grade: 98%. CAS No. 628279-07-2. Molecular formula: C25H26FN5O3. Mole weight: 463.5. | |
| CPFX2090 | CPFX2090 is a cephalosporin antibacterial compound. Synonyms: 5-chloro-1-ethyl-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)quinolin-4(1H)-one. CAS No. 1429439-25-7. Molecular formula: C28H28ClNO6. Mole weight: 509.98. | |
| CPFX4158 | CPFX4158 is a mannose deriviative and an antibacterial agent. Synonyms: CPFX-4158. CAS No. 1804962-84-2. Molecular formula: C51H55NO19. Mole weight: 985.99. | |
| CPG52364 | CPG52364 a small molecule toll-like receptor(TLR) antagonist, which is a type I transmembrane receptors and the central components of the innate immune system. It has recently completed phase 1 clinical trial for SLE therapy. Uses: Cpg52364 is used for the sle therapy. Synonyms: CPG-52364; CPG 52364; CPG52364; 6,7-Dimethoxy-2-(4-(4-methylpiperazin-1-yl)phenyl)-N-(2-morpholinoethyl)quinazolin-4-amine. Grade: >98%. CAS No. 1093135-60-4. Molecular formula: C27H36N6O3. Mole weight: 492.62. | |
| CPG52364 sulfate | CPG52364 sulfate is the sulfate form of CPG52364, which is a small molecule toll-like receptor(TLR) antagonist. It has recently completed phase 1 clinical trial for SLE therapy. Uses: Cpg52364 sulfate is used for the sle therapy. Synonyms: CPG-52364 sulfate; CPG 52364 sulfate; CPG52364 sulfate; 6,7-Dimethoxy-2-(4-(4-methylpiperazin-1-yl)phenyl)-N-(2-morpholinoethyl)quinazolin-4-amine sulfate. Grade: >98%. CAS No. 1093135-62-6. Molecular formula: C27H38N6O7S. Mole weight: 590.70. | |
| CPI-1189 | CPI-1189 is an inhibitor of TNF-α release with the potential use to treat sciatica and postherpetic neuralgia. Synonyms: 4-Acetamido-N-tert-butylbenzamide; CPI-1189; REN-1189; REN-1654; CPI1189; REN1189; REN1654; CPI 1189; REN 1189; REN 1654. CAS No. 183619-38-7. Molecular formula: C13H18N2O2. Mole weight: 234.299. | |
| CPI-1205 | A highly potent and selective EZH2 inhibitor (biochemical IC50=2 nM, cellular EC50=32 nM). Synonyms: CPI-1205; CPI 1205; CPI1205; N-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-1-[(1R)-1-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]ethyl]indole-3-carboxamide; (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide; CPI-1205. CAS No. 1621862-70-1. Molecular formula: C27H33F3N4O3. Mole weight: 518.57. | |
| CPI-1328 | CPI-1328 is a highly potent second-generation EZH2 inhibitor with a Ki of 63 fM. Synonyms: 1,3-Dioxolo[4,5-g]isoquinolin-5(6H)-one, 9-chloro-6-[[1,2-dihydro-6-methyl-4-(methylthio)-2-oxo-3-pyridinyl]methyl]-2-[trans-4-(dimethylamino)cyclohexyl]-7,8-dihydro-2,4-dimethyl-, (2R)-; (R)-9-chloro-2-((1r,4R)-4-(dimethylamino)cyclohexyl)-2,4-dimethyl-6-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinolin-5(6H)-one; CPI1328; CPI 1328. CAS No. 2390367-27-6. Molecular formula: C28H36ClN3O4S. Mole weight: 546.12. | |
| CPI-169 | CPI-169 is a novel and potent EZH2 inhibitor, it decreases cellular levels of H3K27me3 and triggers cell cycle arrest and apoptosis in a variety of cell lines. Synonyms: CPI-169; CPI 169; CPI169. Grade: >98%. CAS No. 1450655-76-1. Molecular formula: C27H36N4O5S. Mole weight: 528.66. | |
| CPI-203 | CPI-203 is a BET bromodomain inhibitor. It inhibits BRD4 in vitro and in cells, and causes G1 cell cycle arrest. It also arrests the growth of T cell acute lymphoblastic leukemia cells in vitro (EC50 = 91.2 nM). Synonyms: CPI203; CPI-203; CPI 203; TEN010; TEN 010; TEN010; JQ-2; JQ 2; JQ2; RG-6146; RG 6146; RG-6146; RO6870810; RO-6870810; RO 6870810. (6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide. Grade: >98%. CAS No. 1446144-04-2. Molecular formula: C19H18ClN5OS. Mole weight: 399.90. | |
| CPI-268456 | CPI-268456 is a ligand of bromodomain-containing protein 4 (BRD4). It binds to BRD4 and inhibits LPS-induced IL-6 secretion in THP-1 cells. Synonyms: 2-[(4S)-8-chloro-6-(4-chlorophenyl)-1-methyl-4H-[1,2]oxazolo[5,4-d][2]benzazepin-4-yl]acetamide. Grade: ≥98%. CAS No. 1380087-86-4. Molecular formula: C20H15Cl2N3O2. Mole weight: 400.3. | |
| CPI-360 | CPI-360 is a potent, selective,and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases. Synonyms: CPI360; CPI 360. Grade: 98%. CAS No. 1802175-06-9. Molecular formula: C25H31N3O4. Mole weight: 437.53. | |
| CPI 4203 | CPI 4203 is a selective inhibitor of KDM5 demethylases structurally related to CPI 455. Synonyms: CPI-4203; CPI 4203; CPI4203; 6-ethyl-7-oxo-5-(o-tolyl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile. Grade: 99%. CAS No. 1628214-07-2. Molecular formula: C16H14N4O. Mole weight: 278.31. | |
| CPI-444 | CPI-444 is a potent, orally available, selective antagonist of the adenosine A2A receptor that has been well tolerated in Ph 1/1b studies in non-oncology indications. Synonyms: (S)-7-(5-methylfuran-2-yl)-3-((6-(((tetrahydrofuran-3-yl)oxy)methyl)pyridin-2-yl)methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine; CPI-444; CPI 444; CPI444; V81444; V-81444; V 81444. CAS No. 1202402-40-1. Molecular formula: C20H21N7O3. Mole weight: 407.17. | |
| CPI 455 | CPI 455 is a selective inhibitor of KDM5 demethylases (IC50 value 10 nM for inhibition of full length KDM5A) that specifically alters H3K4 methylation (H3K4me3) in vitro and reduces survival of drug-tolerant cancer cells. Uses: Antitumor agent for drug-tolerant cancer. Synonyms: CPI-455; CPI-455; CPI-455; 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile. Grade: 99%. CAS No. 1628208-23-0. Molecular formula: C16H14N4O. Mole weight: 278.31. | |
| CPI-455 analogue | CPI-455 analogue is an analogue of CPI-455 which is a KDM5 inhibitor. Molecular formula: C16H14N4O. Mole weight: 278.31. | |
| CPI-455 hydrochloride | CPI-455 is a specific inhibitor of KDM5 with IC50 of 10 ± 1 nM for full-length KDM5A in enzymatic assays. Synonyms: 7-oxo-5-phenyl-6-propan-2-yl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride. Grade: ≥99%. CAS No. 2095432-28-1. Molecular formula: C16H15ClN4O. Mole weight: 314.77. | |
| CPI-613 | CPI-613 is a racemic mixture of the enantiomers of a synthetic alpha-lipoic lipoic acid analogue with potential chemopreventive and antineoplastic activities. Although the exact mechanism of action is unknown, alpha-lipoic acid analogue CPI-613 has been shown to inhibit metabolic and regulatory processes required for cell growth in solid tumors. Both enantiomers in the racemic mixture exhibit antineoplastic activity. The mechanism-of-action of CPI-613 appears distinct from the current classes of anti-cancer agents used in the clinic. CPI-613 demonstrates both in vitro and in vivo anti-tumor activity. CPI-613 was known to strongly disrupt tumor mitochondrial metabolism. CPI-613 disruption of tumor mitochondrial metabolism is followed by efficient commitment to cell death by multiple, apparently redundant pathways, including apoptosis, in all tested cancer cell lines. Further, CPI-613 shows strong antitumor activity in vivo against human non-small cell lung and pancreatic cancers in xenograft models with low side-effect toxicity. Synonyms: CPI613; CPI 613; Devimistat; 6,8-bis(benzylthio)octanoic acid. Grade: 98%. CAS No. 95809-78-2. Molecular formula: C22H28O2S2. Mole weight: 388.59. | |
| CPI-637 | CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor with IC50 of 0.03±0.01μM and 11.0±0.6 μM for CBP/EP300 and BRD4, respectively. CPI-637 displayed a >700-fold selectivity over the BET family of bromodomains (BRD4 IC50=11.0 ± 0.6 μM). Synonyms: CPI-637; CPI 637; CPI637. (4R)-4-methyl-6-[1-methyl-3-(1-methylpyrazol-4-yl)indazol-5-yl]-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one; CPI-637; SCHEMBL17673230. Grade: >98%. CAS No. 1884712-47-3. Molecular formula: C22H22N6O. Mole weight: 386.459. | |
| CPL304110 | CPL304110 is a potent, selective and orally active fibroblast growth factor receptors FGFR (1-3) inhibitor, with IC50s of 0.75, 0.5 and 3.05 nM, respectively. Synonyms: 1H-Benzimidazole, 2-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-6-(4-methyl-1-piperazinyl)-; 2-{5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl}-6-(4-methyl-1-piperazinyl)-1H-benzimidazole. Grade: ≥95%. CAS No. 1627826-19-0. Molecular formula: C25H30N6O2. Mole weight: 446.54. | |
| CPPG | CPPG is the most potent group II/III mGluR antagonist displaying approximately 20-fold selectivity for group III over group II (IC50 = 2.2 and 46.2 nM, respectively). Synonyms: (RS)-α-Cyclopropyl-4-phosphonophenylglycine; Cyclopropyl-4-phosphonophenylglycine; 2-amino-2-cyclopropyl-2-(4-phosphonophenyl)acetic acid. Grade: ≥98% by HPLC. CAS No. 183364-82-1. Molecular formula: C11H14NO5P. Mole weight: 271.21. | |
| CPPHA | CPPHA is a selective positive allosteric modulator of mGluR5 receptor. It is thought to act at a novel allosteric site and potentiates mGlu5 responses by a mechanism distinct from that of VU 29. Grade: >98%. CAS No. 693288-97-0. Molecular formula: C22H15ClN2O4. Mole weight: 406.82. | |
| CPS2 | CPS2 is a first-in-class, highly potent, selective and irreversible PROTAC CDK2 degrader (IC50 = 24 nM) for the study of acute myeloid leukemia. Synonyms: 4-((5-amino-1-(3-methylthiophene-2-carbonyl)-1H-1,2,4-triazol-3-yl)amino)-N-(2-((1-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methoxy)ethyl)benzenesulfonamide; CDK2 degrader CPS2; Benzenesulfonamide, 4-[[5-amino-1-[(3-methyl-2-thienyl)carbonyl]-1H-1,2,4-triazol-3-yl]amino]-N-[2-[[1-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]ethyl]-; 4-[[5-Amino-1-[(3-methyl-2-thienyl)carbonyl]-1H-1,2,4-triazol-3-yl]amino]-N-[2-[[1-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]ethyl]benzenesulfonamide. Grade: ≥95%. CAS No. 2756741-90-7. Molecular formula: C38H42N12O10S2. Mole weight: 890.94. | |
| CPTH2 | CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating Gcn5p network in vitro and in vivo. HAT is an enzyme playing an important role in histone acetylation and multiple cancer development. Uses: Antitumor agent. Synonyms: CPTH2; CPTH 2; CPTH-2; Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone. Grade: 99%. CAS No. 357649-93-5. Molecular formula: C14H14ClN3S. Mole weight: 291.8. | |
| CPTH2 hydrochloride | Gcn5 is a chromatin modifying factor that has HAT activity to acetylate histone H3 lysine 9 (K9) and K14. CPTH2 inhibits the HAT activity of Gcn5. It is used to study the influence of Gcn5-dependent acetylation in various biological systems. Synonyms: 2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone-cyclopentanone monohydrochloride. Grade: ≥95%. CAS No. 2108899-91-6. Molecular formula: C14H14ClN3S·HCl. Mole weight: 328.3. | |
| CPTH6 hydrobromide | CPTH6 is a thiazole derivative structurally and it can inhibit the lysine acetyltransferase activity of Gcn5 and pCAF but not p300 or CBP. Synonyms: 3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone cyclopentanone hydrobromide. Grade: ≥98%. CAS No. 2321332-57-2. Molecular formula: C15H16ClN3S·HBr. Mole weight: 386.7. | |
| CPUY074020 | CPUY074020 is a potent and orally bioavailable histone methyltransferase G9a inhibitor (IC50 = 2.18 μM), with anti-proliferative activity. Synonyms: 3-(1-Piperidyl)-5-[[2-(1-pyrrolidinyl)ethyl]amino]-6H-anthra[1,9-cd]isoxazol-6-one; 6H-Anthra[1,9-cd]isoxazol-6-one, 3-(1-piperidinyl)-5-[[2-(1-pyrrolidinyl)ethyl]amino]-; 3-piperidin-1-yl-5-[(2-pyrrolidin-1-ylethyl)amino]-6H-anthra[1,9-cd]isoxazol-6-one. Grade: ≥95%. CAS No. 902279-44-1. Molecular formula: C25H28N4O2. Mole weight: 416.52. | |
| CPUY201112 | CPUY201112 is an N-terminal Hsp90 inhibitor, which leads to decreased expression of Hsp90 client proteins and may result in increased tumor cell apoptosis. Synonyms: CPUY201112; CPUY 201112; CPUY-201112. Grade: >98%. CAS No. 1860793-58-3. Molecular formula: C19H23N3O4. Mole weight: 357.41. | |
| CPYPP | CPYPP has been found to be a DOCK2-Rac1 interaction inhibitor and could probably attenuate HER2-mediated breast cancer cell migration. Synonyms: 4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione. Grade: ≥98% by HPLC. CAS No. 310460-39-0. Molecular formula: C18H13ClN2O2. Mole weight: 324.76. | |
| CPZEN-45 | CPZEN-45 exhibits potent antibacterial activity against several DS, as well as MDR and XDR strains of Mtb in murine models and exhibits synergistic effects with other TB drugs. Synonyms: Caprezene-4-butylanilide; (2S)-2-[(S)-[(2S,3R,4S,5R)-5-(aminomethyl)-3,4-dihydroxy-tetrahydrofuran-2-yl]oxy-[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl]-N-(4-butylphenyl)-1,4-dimethyl-3-oxo-2,7-dihydro-1,4-diazepine-5-carboxamide. Molecular formula: C32H44N6O11. Mole weight: 688.72. | |
| CR-1-31-B | CR-1-31-B is a potent eIF4A RNA helicase inhibitor. CR-1-31-B exhibits powerful inhibitory effects over eIF4A by perturbing the interaction between eIF4A and RNA, sequentially impeding initiation during protein synthesis. CR-1-31-B induces apoptosis of neuroblastoma and gallbladder cancer cells. Synonyms: CR-1-31-B; 1352914-52-3; CHEMBL2058177; (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-N,6,8-trimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide; CR-1-31B; BDBM50388144; AKOS040756670; MS-29423; HY-136453; CS-0129555. Grade: 98%. CAS No. 1352914-52-3. Molecular formula: C28H29NO8. Mole weight: 507.53. | |
| CR4056 | CR4056 is an imidazoneuline I2 receptor ligand potentially for treatment of neuropathic pain. CR4056 is a selective inhibitor of MAO-A with IC50 of 202.7 nM. Synonyms: CR-4056; 6-(1H-imidazol-1-yl)-2-phenylquinazoline; 2-Phenyl-6-(1H-imidazol-1-yl)quinazoline. CAS No. 1004997-71-0. Molecular formula: C17H12N4. Mole weight: 272.30. | |
| CR8 | CR8 is a potent and selective inhibitor of CDK. CR8 is a more potent pyridyl analogue of roscovitine. In comparison to roscovirtine, the compound gains in potency toward CK1, which is involved in amyloid-β formation. The R-CR8 enantiomer is slightly more potent than S. CR8 is around 30 times more potent at cellular assay then roscovitine. (R)?-CR8 induces apoptosis and has neuroprotective effect. (R)-CR8 acts as a molecular glue degrader that depletes cyclin K. Synonyms: (R)-CR8; CR 8; CR-8. Grade: 98%. CAS No. 294646-77-8. Molecular formula: C24H29N7O. Mole weight: 431.544. | |
| CRA-026440 | CRA-026440 is a potent and broad-spectrum inhibitor of HDAC with Kis of 4, 14, 11, 15, 7 and 20 nM against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 and HDAC10, respectively. Synonyms: 1H-Indole-2-carboxamide, 5-[2-(dimethylamino)ethoxy]-N-[3-[4-[(hydroxyamino)carbonyl]phenyl]-2-propyn-1-yl]-; 5-[2-(Dimethylamino)ethoxy]-N-{3-[4-(hydroxycarbamoyl)phenyl]-2-propyn-1-yl}-1H-indole-2-carboxamide. Grade: ≥95%. CAS No. 847460-34-8. Molecular formula: C23H24N4O4. Mole weight: 420.46. | |
| CRAC inhibitor 44 | CRAC inhibitor 44 is a potent and selective CRAC ion channel inhibitor suppressing CRAC ion channel activity and the production of IL-2, IL-4, IL-5, IL-13, GM-CSF, TNF-α, and IFNγ. Grade: 99%. CAS No. 944917-72-0. Molecular formula: C22H19F2N3OS. Mole weight: 411.47. | |
| CRAC intermediate 1 | A significant intermediate in the production of sorts of CRAC channel inhibitors. Uses: A significant intermediate in the production of sorts of crac channel inhibitors. Synonyms: CRAC intermediate 1; SCHEMBL706559; UMBVHXNGQIFPCN-UHFFFAOYSA-N; AKOS010652441; CS-3896; CS 3896; CS3896. Grade: 98%. CAS No. 1249343-86-9. Molecular formula: C10H7F2N3O. Mole weight: 223.18. | |
| CRAMP (mouse) | This cathelicidin-related antimicrobial peptide (CRAMP) is the sole murine cathelicidin. CRAMP expression in the intestinal tract is restricted to surface epithelial cells in the colon. CRAMP shows antimicrobial activity against the murine enteric pathogen Citrobacter rodentium and destroys skin Candida albicans. Synonyms: H-Gly-Leu-Leu-Arg-Lys-Gly-Gly-Glu-Lys-Ile-Gly-Glu-Lys-Leu-Lys-Lys-Ile-Gly-Gln-Lys-Ile-Lys-Asn-Phe-Phe-Gln-Lys-Leu-Val-Pro-Gln-Pro-Glu-Gln-OH; CRAMP, mouse; CRAMP (mouse) (TFA salt). Grade: ≥95%. CAS No. 376364-36-2. Molecular formula: C178H302N50O46. Mole weight: 3878.60. | |
| CRANAD 28 | CRANAD 28 is a curcumin derivative and a fluorescent probe for labeling amyloid-β (Aβ) plaques and cerebral amyloid angiopathy. The fluorescence intensity decreases when bound to Aβ. It also inhibits copper-induced and naturally occurring Aβ crosslinking. Synonyms: CRANAD-28; CRANAD 28; CRANAD28. Grade: ≥98%. CAS No. 1623747-97-6. Molecular formula: C27H23BF2N4O2. Mole weight: 484.3. | |
| Creatine Gluconate | Creatine Gluconate is a salient nitrogenous organic acid, serving as an invigorating supplement in studying heightening both muscle strength and endurance. This scientific compound finds its prodigious utility in studying an array of afflictions tethered to muscle enfeeblement and degeneration. Molecular formula: C10H19N3O9. Mole weight: 325.27. | |
| Creatine Hydrochloride | Creatine is found in vertebrates where it facilitates recycling of adenosine triphosphate (ATP). Creatine can be used as a buffer. Nutritional supplement in health care products. Uses: Ingredient of health care products. Synonyms: Creatine HCl; 2-(1-Methylguanidino)acetic acid hydrochloride; 2-[carbamimidoyl(methyl)amino]acetic acid hydrochloride. Grade: 95%. CAS No. 17050-09-8. Molecular formula: C4H10ClN3O2. Mole weight: 167.593. | |
| Creatine monohydrate | Creatine is found in vertebrates where it facilitates recycling of adenosine triphosphate (ATP). Creatine can be used as a buffer.Nutritional supplement in health care products. Uses: Ingredient of health care products. Synonyms: 2-[carbamimidoyl(methyl)amino]acetic acid; hydrate. CAS No. 6020-87-7. Molecular formula: C4H11N3O3. Mole weight: 149.15. | |
| Creatine phosphate disodium salt hexahydrate | Creatine phosphate disodium salt hexahydrate is a familiar compound employed in the research of neuromuscular pathologies, serving as a pivotal substrate, effectively fostering adenosine triphosphate (ATP) regeneration while facilitating energy synthesand storage imperative for muscle contraction. Synonyms: Phosphocreatine. CAS No. 6190-45-0. Molecular formula: C4H21N3NaO11P. Mole weight: 341.186. | |
| Creatine Phosphate Disodium Salt Tetrahydrate | Creatine Phosphate Disodium Salt Tetrahydrate is a crucial compound in the biomedical industry playing a vital role in cellular metabolism. This product is utilized in researchs targeting various neuromuscular disorders, such as muscular dystrophy and chronic fatigue syndrome. Synonyms: Sodium creatine phosphate dibasic tetrahydrate. Grade: > 95%. CAS No. 71519-72-7. Molecular formula: C4H8N3O5PNa2 4H2O. Mole weight: 327.14. | |
| Creatine riboside | Creatine riboside is a urinary metabolite associated with risk and prognosis in lung and liver cancer. Synonyms: beta-D-Ribofuranosylcreatine. Grade: >98%. CAS No. 1616693-92-5. Molecular formula: C9H17N3O6. Mole weight: 263.25. | |
| Creatinine | Creatinine is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body. Synonyms: Creatinine; NSC 13123; NSC-13123; NSC13123. Grade: >98%. CAS No. 60-27-5. Molecular formula: C4H7N3O. Mole weight: 113.12. | |
| CREDAZINE | CREDAZINE is a kind of Pesticide as a herbicide. Uses: Herbicide. Synonyms: Credazine; Kusakira; NIA-20439; SW-670; SW-6721; H-722; BRN-0880257; NIA 20439; SW 670; SW 6721; H 722; BRN 0880257; NIA20439; SW670; SW6721; H722; BRN0880257; Pyridazine, 3-(2-methylphenoxy)-; 3-(2-Methylphenoxy)pyridazine. Grade: 98%. CAS No. 14491-59-9. Molecular formula: C11H10N2O. Mole weight: 186.21. | |
| Crenezumab | Crenezumab is a humanized monoclonal antibody that targets β-amyloid oligomers. Crenezumab has been investigated for the treatment of early AD. Synonyms: RG 7412; RG-7412; RG7412. Grade: 95%. CAS No. 1095207-05-8. Molecular formula: C6442H9966N1706O2018S40. Mole weight: 144.9 kDa. | |
| Crenolanib | Crenolanib is an orally bioavailable small molecule, targeting the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Crenolanib binds to and inhibits PDGFR, which may result in the inhibition of PDGFR-related signal transduction pathways, and, so, the inhibition of tumor angiogenesis and tumor cell proliferation. PDGFR, up-regulated in many tumor cell types, is a receptor tyrosine kinase essential to cell migration and the development of the microvasculature. Synonyms: CP 868596; CP868596; CP-868596; ARO 002; RO-002; RO002; Crenolanib. CAS No. 670220-88-9. Molecular formula: C26H29N5O2. Mole weight: 443.551. | |
| cRIPGBM | cRIPGBM is a proapoptotic derivative of RIPGBM. It acts as a cell type-selective inducer of apoptosis in GBM cancer stem cells (CSCs) by binding to receptor-interacting protein kinase 2 (RIPK2), with an EC50 of 68 nM in GBM-1 cells. CAS No. 2361988-76-1. Molecular formula: C26H20FN2O2+. Mole weight: 411.45. | |
| crisaborole | Crisaborole is a novel PDE-4 inhibitor used as a nonsteroidal topical medication for the treatment of mild-to-moderate atopic dermatitis (eczema). Crisaborole selectively inhibits PDE-4B which mainly leads to inflammation. Tumor necrosis factor alpha (TNFα), interleukin-12 (IL-12), IL-23 and other cytokines are also suppressed while crisaborole functioning. Uses: The treatment of mild-to-moderate atopic dermatitis (eczema). Synonyms: AN2728; AN-2728; AN 2728; Crisaborole; Eucrisa; 4-((1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)benzonitrile. Grade: 99%. CAS No. 906673-24-3. Molecular formula: C14H10BNO3. Mole weight: 251.048. | |
| Crisdesalazine | Crisdesalazine is a microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor potentially for the treatment of Alzheimer's type dementia, Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Arthritis, Depression, Diabetes and Pancreatitis. Synonyms: AAD-2004; Benzoic acid, 2-hydroxy-5-((2-(4-(trifluoromethyl)phenyl)ethyl)amino)-. CAS No. 927685-43-6. Molecular formula: C16H14F3NO3. Mole weight: 325.28. | |
| Crizanlizumab | Crizanlizumab is a monoclonal antibody used for the prevention of vaso-occlusive crises (VOCs) in patients with sickle cell disease (SCD). Crizanlizumab binds to P-selectin, a cell adhesion molecule expressed on the surface of activated endothelial cells and platelets. By inhibiting P-selectin, crizanlizumab helps prevent the adhesion of sickle red blood cells to the endothelium and other blood cells, which is a key step in the initiation of VOCs in patients with SCD. It is indicated for the prevention of VOCs in patients with SCD. Vaso-occlusive crises are episodes of severe pain caused by the blockage of blood flow in small blood vessels, leading to tissue ischemia and organ damage. Crizanlizumab aims to reduce the frequency and severity of these painful episodes. Synonyms: Immunoglobulin G2, anti-(human P-selectin) (human-Mus musculus monoclonal SelG1 heavy chain), disulfide with human-Mus musculus monoclonal SelG1 light chain, dimer; Adakveo; Crizanlizumab-tmca; SEG 101; SelG 1. CAS No. 1690318-25-2. | |
| Crizotinib | Crizotinib is an anti-cancer drug acting as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor. Uses: Antineoplastic agents. Synonyms: PF-02341066; PF 02341066; PF02341066. Grade: >98%. CAS No. 877399-52-5. Molecular formula: C21H22Cl2FN5O. Mole weight: 450.343. | |
| Crizotinib hydrochloride | Crizotinib is inhibitor of the c-Met kinase and the NPM-ALK. Crizotinib inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM). Crizotinib is useful in treatment of anaplastic large-cell lymphoma. Synonyms: PF-02341066 hydrochloride; PF 02341066 hydrochloride; PF02341066 hydrochloride. Grade: >98%. CAS No. 1415560-69-8. Molecular formula: C21H23Cl3FN5O. Mole weight: 486.8. | |
| Crizotinib piperidin-1-Hydroxy Impurity | An impurity of Crizotinib, a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent. Grade: ≥95%. Molecular formula: C21H22Cl2FN5O2. Mole weight: 466.34. | |
| Crolibulin | Crolibulin, also known as EPC2407 and crinobulin, is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity. Microtubulin inhibitor EPC2407 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of tubulin into microtubules, which may result in cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. As a vascular disruption agent (VDA), this agent also disrupts tumor neovascularization, which may result in a reduction in tumor blood flow and tumor hypoxia and ischemic necrosis. Synonyms: EPC2407; EPC 2407; EPC-2407; (R)-2,7,8-triamino-4-(3-bromo-4,5-dimethoxyphenyl)-4H-chromene-3-carbonitrile. CAS No. 1000852-17-4. Molecular formula: C18H17BrN4O3. Mole weight: 417.263. | |
| Cromakalim | Cromakalim is a prototypical Kir6 (KATP) channel opener. It is used as a potassium channel-opening vasodilator. It acts on ATP-sensitive potassium channels and causes membrane hyperpolarization. It displays cardioprotective and anti-ischemic effects in rat hearts. It can be used to treat hypertension because it will relax vascular smooth muscle to lower blood pressure. It has been used to investigate potassium channel biology and as a scaffold to develop increasingly selective K+ channel openers with clinical relevance. It is orally active in vivo. Synonyms: BRL 34915; BRL-34915; BRL34915; Cromakalim; (±)-Cromakalim; (±)-Cromakalim; (3R,4S)-rel-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile; trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile; (±)-trans-6-Cyano-3,4-dihydro-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-2H-1-benzopyran-3-ol. Grade: ≥99% by HPLC. CAS No. 94470-67-4. Molecular formula: C16H18N2O3. Mole weight: 286.33. | |
| Cromolyn | Cromolyn, a chromene derivative, could be used in the treatmen of allergic an a aast cell stabiliser. Uses: Anti-asthmatic agents. Synonyms: Cromolyn; Cromoglicic acid; Cromoglycate; Acido cromoglicico; Acide cromoglicique. Grade: 98%. CAS No. 16110-51-3. Molecular formula: C23H16O11. Mole weight: 468.37. | |
| Cromolyn-d5 | Cromolyn-d5 is a labellled Cromolyn. Cromolyn is a medication of the mast cell stabilizer class used for the treatment of mastocytosis. Grade: > 95%. Molecular formula: C23H11O11D5. Mole weight: 473.41. | |
| Croscarmellose sodium | Croscarmellose sodium is a crosslinked polymer of carboxymethyl cellulose sodium. Croscarmellose sodium is used as a disintegrating agent in capsules, tablets and granules in oral pharmaceutical formulations. Synonyms: Sodium carboxymethyl cellulose; Ac-Di-Sol; carmellosum natricum conexum; crosslinked carboxymethylcellulose sodium; Explocel; modified cellulose gum; Nymcel ZSX; Pharmacel XL; Primellose; Solutab; Vivasol. CAS No. 74811-65-7. | |
| Crotamiton | Crotamiton is a general antipruritic agent for treating scabies. Uses: An anti-parasitic agent. Synonyms: N-Ethyl-o-crotonotoluidide; 2-Butenamide, N-ethyl-N-(2-methylphenyl)-; N-Ethyl-N-(2-methylphenyl)-2-butenamide; o-Crotonotoluidide, N-ethyl-; Crotalgin; Crotamitex; Crotamitone; Crotonyl N-ethyl-o-toluidine; Eurax; Euraxil; N-Crotonyl-N-ethyl-o-toluidine; Veteusan. Grade: ≥95%. CAS No. 483-63-6. Molecular formula: C13H17NO. Mole weight: 203.28. | |
| CRSP-1 | CRSP-1 has been found to be an endogenous central calcitonin (CT) receptor agonist and could reduce plasma calcium levels in vivo. Synonyms: CRSP-1; CRSP 1; CRSP1. Grade: ≥95% by HPLC. CAS No. 697327-12-1. Molecular formula: C175H294N54O49S5. Mole weight: 4098.88. | |
| CRT0066101 | CRT0066101 is a small-molecule protein kinase D (PKD) inhibitor that suppresses PDK1, PDK2 and PDK3 (PDK1: IC50 = 1 nM; PDK2: IC50 = 2.5 nM; PDK3: IC50 = 2 nM). Studies in vivo showed that CRT0066101 inhibited pancreatic cancer growth. Synonyms: Phenol, 2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)-, hydrochloride (1:2); (R)-2-(4-((2-Aminobutyl)amino)pyrimidin-2-yl)-4-(1-methyl-1H-pyrazol-4-yl)phenol dihydrochloride; 2-(4-{[(2R)-2-Aminobutyl]amino}pyrimidin-2-yl)-4-(1-methyl-1H-pyrazol-4-yl)phenol dihydrochloride; CRT 0066101; CRT-0066101; CRT0066101 dihydrochloride. Grade: ≥95%. CAS No. 1883545-60-5. Molecular formula: C18H22N6O.2HCl. Mole weight: 411.33. | |
| CRT0066101 hydrochloride | CRT0066101 is an inhibitor of all three PKD isoforms (IC50s = 1, 2.5, and 2 nM for PKD1, PKD2, and PKD3, respectively). It exhibits selectivity for PKD against a panel of >90 protein kinases, including PKCα, PKBα, MEK, ERK, c-Raf, c-Src, and c-Abl. Synonyms: Phenol, 2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)-, hydrochloride (1:3); (R)-2-(4-((2-Aminobutyl)amino)pyrimidin-2-yl)-4-(1-methyl-1H-pyrazol-4-yl)phenol trihydrochloride; 2-(4-{[(2R)-2-Aminobutyl]amino}pyrimidin-2-yl)-4-(1-methyl-1H-pyrazol-4-yl)phenol trihydrochloride. Grade: ≥95%. CAS No. 1781742-22-0. Molecular formula: C18H22N6O.3HCl. Mole weight: 447.79. | |
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