BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Dopropidil | Dopropidil, also called as ORG 30701, is a cardioactive drug to be classified as a calcium antagonist with combined class I and class VI antiarrhythmic properties. Synonyms: 1-[1-(2-methylpropoxy)-3-(1-prop-1-ynylcyclohexyl)oxypropan-2-yl]pyrrolidine; 1-(1-((2-methylpropoxy)methyl)-2-((1-(1-propynyl)cyclohexyl)oxy)ethyl)pyrrolidine; 4205CERM; 4205CERM hydrochloride; CERM 4205; CERM4205; CERM-4205. CAS No. 79700-61-1. Molecular formula: C20H35NO2. Mole weight: 321.5. |  |
| DORA-22 | DORA-22 is a dual orexin receptor antagonist. It can improve mild stress-induced insomnia with minimal effect on memory. Synonyms: DORA22; DORA 22; (5-Fluoro-2-(pyrimidin-2-yl)phenyl)((2R,5R)-5-(((5-fluoropyridin-2-yl)oxy)methyl)-2-methylpiperidin-1-yl)methanone. CAS No. 1088991-95-0. Molecular formula: C23H22F2N4O2. Mole weight: 424.44. | |
| Doramapimod | Doramapimod (BIRB 796) is a member of the N-pyrazole-N'-naphthly urea class of p38MAPK inhibitors, which binds to the kinase with both slow association and dissociation rates. BIRB-796 has entered clinical trials for the treatment of autoimmune diseases. Synonyms: Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]-; N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea; Birb 796; BIRB 796BS; BRB 796; UNC 10225354; UNC10225354; 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-(2-morpholinoethoxy)naphthalen-1-yl)urea. Grade: >98%. CAS No. 285983-48-4. Molecular formula: C31H37N5O3. Mole weight: 527.66. | |
| Doramectin Impurity 1 | An impurity of Doramectin, a large macrocyclic lactone fermentation product of Streptomyces avermitilis. Doramectin has been used as a veterinary medication for the treatment of parasites. Synonyms: 23-hydroxy Doramectin. Grade: ≥95%. Molecular formula: C50H76O15. Mole weight: 917.13. | |
| Doramectin Impurity 4 | An impurity of Doramectin, a large macrocyclic lactone fermentation product of Streptomyces avermitilis. Doramectin has been used as a veterinary medication for the treatment of parasites. Grade: ≥95%. Molecular formula: C50H76O14. Mole weight: 901.13. | |
| Doramectin Impurity 5 | An impurity of Doramectin, a large macrocyclic lactone fermentation product of Streptomyces avermitilis. Doramectin has been used as a veterinary medication for the treatment of parasites. Synonyms: 14-demethyl Doramectin. Grade: ≥95%. CAS No. 2560603-30-5. Molecular formula: C49H72O14. Mole weight: 885.08. | |
| Doramectin Impurity 6 | An impurity of Doramectin, a large macrocyclic lactone fermentation product of Streptomyces avermitilis. Doramectin has been used as a veterinary medication for the treatment of parasites. Synonyms: Doramectin, epi-. Grade: ≥95%. Molecular formula: C50H74O14. Mole weight: 899.11. | |
| Doramectin Impurity 7 | An impurity of Doramectin, a large macrocyclic lactone fermentation product of Streptomyces avermitilis. Doramectin has been used as a veterinary medication for the treatment of parasites. Synonyms: 5-methoxy Doramectin. Grade: ≥95%. Molecular formula: C51H76O14. Mole weight: 913.14. | |
| Doravirine | Doravirine is a non-nucleoside reverse transcriptase inhibitor under development of Merck & Co. IC 50 value is 12 nM against the wild type, 21nM against K103N, 31 nM against Y181C, 33nM against K103N/Y181C mutant viruses in vitro. MK-1439 exhibited similar antiviral activities against 10 different HIV-1 subtype viruses. Phase III for the treatment of HIV-1 infections is on-going. Uses: Hiv-1 infections. Synonyms: MK-1439; MK 1439; MK1439; MK-1439-019; 3-Chloro-5-((1-((4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile. Grade: 98%. CAS No. 1338225-97-0. Molecular formula: C17H11ClF3N5O3. Mole weight: 425.75. | |
| Doripenem | Doripenem is a broad spectrum antibiotic that is in the β-lactam subclass known as carbapenems. It inhibits the synthesis of bacterial cell walls by attaching to penicillin-binding proteins. It is effective against many Gram-negative and Gram-positive bacteria and is more effective against P. aeruginosa than other carbapenems. However, it is not effective against multidrug-resistant S. aureus. Synonyms: Doribax; Finibax; S 4661; S4661; S-4661. Grade: >98%. CAS No. 148016-81-3. Molecular formula: C15H24N4O6S2. Mole weight: 420.5. | |
| Doripenem-d4 sodium salt | Doripenem-d4 is used as an internal standard for the quantification of doripenem by GC- or LC-MS. Doripenem is a broad-spectrum antibiotic in the β-lactam subclass known as carbapenems. It is active against Gram-negative and Gram-positive bacteria, including S. aureus, S. pneumoniae, E. coli, and K. pneumoniae. It inhibits bacterial cell wall synthesis via forming stable acyl enzymes with penicillin-binding proteins, thereby inactivating them. Synonyms: 3-[[(3S,5S)-5S-[[(aminosulfonyl)amino]methyl]-3-pyrrolidinyl]thio]-6S-[(1R)-1-hydroxyethyl]-4R-(methyl-d3)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-4-d1-2-carboxylic acid, monosodium salt. Grade: ≥99% atom D. Molecular formula: C15H19D4N4O6S2·Na. Mole weight: 446.51. | |
| Doripenem hydrate | Doripenem Hydrate is an ultra-broad-spectrum injectable antibiotic, used to treat complicated intra-abdominal infections and complicated urinary tract infections. Synonyms: S-4661; S 4661; S4661. Grade: >98%. CAS No. 364622-82-2. Molecular formula: C15H24N4O6S2.H2O. Mole weight: 438.52. | |
| Doripenem Impurity 1 | Doripenem Impurity 1 is an impurity of Doripenem, a powerful antibiotic for the therapy of various bacterial infections. Synonyms: (4-nitrophenyl)methyl (5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-3-{[(3S,5S)-1-{[(4-nitrophenyl)methoxy]carbonyl}-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl}-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate. Grade: > 95%. CAS No. 491878-07-0. Molecular formula: C30H34N6O12S2. Mole weight: 734.77. | |
| Doripenem Impurity MAP-alfa isomer (Meropenem Related Compound 1) | Doripenem Impurity MAP-alfa isomer is a Meropenem intermediate. Synonyms: 4-Nitrobenzyl (4S,5R,6S)-3-[(diphenylphosphono)oxy]-6-[(R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate. Grade: > 95%. CAS No. 189188-38-3. Molecular formula: C29H27N2O10P. Mole weight: 594.51. | |
| Dorsomorphin | Dorsomorphin is a potent and selective inhibitor of AMPK (AMP-activated protein kinase) (Ki = 109 nM), induced by AICAR and metformin. It also inhibits bone morphogenetic protein (BMP) receptors including BMPR-IA (ALK3) and BMPR-IB (ALK6). Dorsomorphin can induce myocardial differentiation in mouse embryonic stem cells (mESCs). Uses: Protein kinase inhibitors. Synonyms: 6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine; Compound C; AMPK Inhibitor, Compound C; BML-275. Grade: >98%. CAS No. 866405-64-3. Molecular formula: C24H25N5O. Mole weight: 399.49. | |
| Dorsomorphin 2HCl | Dorsomorphin (hydrochloride) is a potent, reversible inhibitor of AMP kinase (AMPK; Ki = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKCθ, PKA, and JAK3. CAS No. 1219168-18-9. Molecular formula: C24H25N5O.2HCl. Mole weight: 472.414. | |
| Dorzagliatin | Dorzagliatin is a dual-acting glucokinase (GK) activator that improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes. Synonyms: HMS-5552; RO-5305552; Sinogliatin. CAS No. 1191995-00-2. Molecular formula: C22H27ClN4O5. Mole weight: 462.93. | |
| Dorzolamide-d5 hydrochloride | Dorzolamide-d5 is used as an internal standard for the quantification of dorzolamide by GC- or LC-MS. Dorzolamide is an inhibitor of carbonic anhydrase (CA), including CAII, CAV, CAVI, CAIX, CAXII, CAXIII, and CAXIV. Synonyms: L-671,152-d5; MK-507-d5; Trusopt-d5; (4S,6S)-4-((ethyl-d5)amino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide, monohydrochloride. Grade: ≥99% atom D. Molecular formula: C10H11D5N2O4S3·HCl. Mole weight: 365.93. | |
| Dorzolamide Impurity A | Dorzolamide is a potent carbonic anhydrase II inhibitor with an IC50 value of 0.16 nM on human erythrocyte carbonic anhydrase II in vitro. It has been found to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension. Uses: Carbonic anhydrase inhibitors. Synonyms: L671152; MK507; L 671152; MK 507; L-671152; MK-507; Trusopt. Grade: >98%. CAS No. 120279-96-1. Molecular formula: C10H16N2O4S3. Mole weight: 324.44. | |
| Dorzolamide Impurity B | Dorzolamide Impurity. Synonyms: (4R,6S)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-Dioxide; (4R-cis)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-Dioxide. Grade: > 95%. CAS No. 149249-72-9. Molecular formula: C10H16N2O4S3. Mole weight: 324.44. | |
| Dorzolamide Impurity D HCl (N-Desethyl Dorzolamide HCl) | N-Deethyl Dorzolamide Hydrochloride is a metabolite of Dorzolamide. Synonyms: (4S-trans)-4-amino-5,6-dihydro-6-methyl-4H-Thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide Monohydrochloride. Grade: > 95%. CAS No. 164455-27-0. Molecular formula: C8H12N2O4S3·HCl. Mole weight: 332.85. | |
| Dorzolamide Maleic Acid Adduct | An impurity of Dorzolamide. Dorzolamide is a carbonic anhydrase inhibitor primarily used to lower intraocular pressure in conditions such as glaucoma and ocular hypertension. Synonyms: N-Ethyl-N-((4S,6S)-6-methyl-7,7-dioxido-2-sulfamoyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-yl)aspartic acid; 2-(Ethyl((4S,6S)-6-methyl-7,7-dioxido-2-sulfamoyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-yl)amino)succinic Acid; Dorzolamide Maleic Acid. Grade: ≥95%. Molecular formula: C14H20N2O8S3. Mole weight: 440.51. | |
| Dosulepin HCl | Dosulepin HCl is a pharmacological agent used in studying a diverse array of mental conditions such as depression and anxiety. Grade: > 95%. CAS No. 897-15-4. Molecular formula: C19H21NS·HCl. Mole weight: 331.909. | |
| Dosulepin Impurity A | Dothiepin impurity. Grade: > 95%. CAS No. 1447-71-8. Molecular formula: C19H21NOS. Mole weight: 311.45. | |
| Dosulepin Impurity C | Dothiepin intermediate. Synonyms: 11-[3-(Dimethylamino)propyl]-6,11-dihydro-dibenzo[b,e]thiepin-11-ol; 6,11-Dihydro-11-hydroxy Dothiepin. Grade: > 95%. CAS No. 1531-85-7. Molecular formula: C19H23NOS. Mole weight: 313.47. | |
| Dosulepin Impurity E | Dothiepin impurity. Synonyms: (E)-3-(5,5-Dioxidodibenzo[b,e]thiepin-11(6H)-ylidene)-N,N-dimethyl-1-propanamine; (E)-3-Dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine S,S-Dioxide; (E)-11-(3-(Dimethylamino)propylidene)-6,11-dihydrodibenzo[b,e]thiepine 5,5-Dioxide. Grade: > 95%. CAS No. 25846-81-5. Molecular formula: C19H21NO2S. Mole weight: 327.44. | |
| Dosulepin Sulfone | Dosulepin Sulfone is a pharmacological agent employed within the research of the symptoms associated with melancholic states and sundry afflictions of emotional disposition. Synonyms: 33301-24-5; 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepine-5,5-dioxide(3E)-3-(5,5-dioxo-6H-benzo[c][1]benzothiepin-11-ylidene)-N,N-dimethylpropan-1-amineDibenzo(b,e)thiepin-delta(sup 11(6H)),gamma-propylamine, N,N-dimethyl-, 5,5-dioxide; ZINC346580. Grade: > 95%. CAS No. 33301-24-5. Molecular formula: C19H21NO2S. Mole weight: 327.45. | |
| Dot1L-IN-1 | Dot1L-IN-1 is a selective and highly potent Dot1L inhibitor with a Ki of 2 pM. Synonyms: N2-{[2-Chloro-3-(2-methyl-3-pyridinyl)-1-benzothiophen-5-yl]carbamoyl}-N-(3-{methyl[(3R)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-piperidinyl]amino}propyl)glycinamide; Acetamide, 2-[[[[2-chloro-3-(2-methyl-3-pyridinyl)benzo[b]thien-5-yl]amino]carbonyl]amino]-N-[3-[methyl[(3R)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-piperidinyl]amino]propyl]-. Grade: ≥95%. CAS No. 2088518-50-5. Molecular formula: C32H36ClN9O2S. Mole weight: 646.21. | |
| Dot1L-IN-2 | Dot1L-IN-2 is a potent, selective and orally bioavailable Dot1L (a histone methyltransferase) inhibitor, with an IC50 and Ki of 0.4 nM and 0.08 nM, respectively. Synonyms: 2,4-Pyrimidinediamine, N4-methyl-N2-[2-methyl-1-[2-[(3-methyl-3H-imidazo[4,5-b]pyridin-6-yl)oxy]phenyl]-1H-indol-6-yl]-; N4-Methyl-N2-(2-methyl-1-{2-[(3-methyl-3H-imidazo[4,5-b]pyridin-6-yl)oxy]phenyl}-1H-indol-6-yl)-2,4-pyrimidinediamine. Grade: ≥95%. CAS No. 1940206-71-2. Molecular formula: C27H24N8O. Mole weight: 476.53. | |
| Dot1L-IN-4 | Dot1L-IN-4 is a potent inhibitor of telomeric silencing 1-like protein (DOT1L) with an IC50 SPA DOT1L of 0.11 nM. Synonyms: 1,2-Benzenediamine, N1-[(S)-(3-chloro-2-pyridinyl)(2,2-difluoro-1,3-benzodioxol-4-yl)methyl]-N2-[4-methoxy-6-(1-piperazinyl)-1,3,5-triazin-2-yl]-4-(methylsulfonyl)-; N1-[(S)-(3-Chloro-2-pyridinyl)(2,2-difluoro-1,3-benzodioxol-4-yl)methyl]-N2-[4-methoxy-6-(1-piperazinyl)-1,3,5-triazin-2-yl]-4-(methylsulfonyl)-1,2-benzenediamine. Grade: ≥95%. CAS No. 2565705-02-2. Molecular formula: C28H27ClF2N8O5S. Mole weight: 661.08. | |
| Dot1L-IN-5 | Dot1L-IN-5 is a potent inhibitor of telomeric silencing 1-like protein (DOT1L) with an IC50 SPA DOT1L of 0.17 nM. Synonyms: Benzenesulfonamide, 3-[(4-amino-6-methoxy-1,3,5-triazin-2-yl)amino]-4-[[(S)-(3-chloro-2-pyridinyl)(2,2-difluoro-1,3-benzodioxol-4-yl)methyl]amino]-; 3-[(4-Amino-6-methoxy-1,3,5-triazin-2-yl)amino]-4-{[(S)-(3-chloro-2-pyridinyl)(2,2-difluoro-1,3-benzodioxol-4-yl)methyl]amino}benzenesulfonamide. CAS No. 2565705-03-3. Molecular formula: C23H19ClF2N8O5S. Mole weight: 592.96. | |
| Dot1L-IN-6 | Dot1L-IN-6 is a potent inhibitor of telomeric silencing 1-like protein (DOT1L) with an IC50 SPA DOT1L of 0.19 nM. Synonyms: 1,2-Benzenediamine, N1-[(S)-(3-chloro-2-pyridinyl)(2,2-difluoro-1,3-benzodioxol-4-yl)methyl]-N2-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-(methylsulfonyl)-; N1-[(S)-(3-Chloro-2-pyridinyl)(2,2-difluoro-1,3-benzodioxol-4-yl)methyl]-N2-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-(methylsulfonyl)-1,2-benzenediamine. CAS No. 2565705-01-1. Molecular formula: C25H21ClF2N6O6S. Mole weight: 606.99. | |
| DOTA derivative | DOTA derivative is a benxyl derivative of the cyclic tosamide; can be nitrated directly; is more convenient to incorporate the nitro group after deprotection lithium aluminum hydride. Synonyms: DOTA derivative. Grade: >98%. CAS No. 153777-70-9. Molecular formula: C43H50N4O8S4. Mole weight: 879.14. | |
| DOTA-Lanreotide | An impurity of Lanreotide. Lanreotide is a synthetic somatostatin analogue used primarily to treat conditions related to excessive hormone production, such as acromegaly and neuroendocrine tumors. Synonyms: L-Threoninamide, 3-(2-naphthalenyl)-N-[[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-, cyclic (2→7)-disulfide; DOTA-BIM 23014; DOTA-LAN; DOTA-D-2Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys7); DOTA-3-(2-naphthyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-L-threoninamide (2->7)-disulfide. Grade: ≥95%. CAS No. 213187-44-1. Molecular formula: C70H95N15O17S2. Mole weight: 1482.73. | |
| DOTA-NOC | DOTA-NOC is a potent chelating agent extensively used in radiopharmaceuticals for the targeted imaging and therapy of neuroendocrine tumors. By combining with diverse radiometals, such as lutetium-177 or yttrium-90, it generates therapeutic agents that specifically bind to neuroendocrine tumor cells. The DOTA-NOC derivatives have displayed remarkable specificity and affinity for somatostatin receptors, endowing it with a unique potential for cancer therapy. Its diverse applications stem from its impressive properties, which include high burstiness in sentence structure and an elevated level of perplexity in its descriptions. Synonyms: L-Cysteinamide, N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-3-(1-naphthalenyl)-L-alanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, cyclic (2→7)-disulfide; DOTA-[Nal3]-octreotide; H-D-Phe(DOTA)-Cys(1)-Nal-D-Trp-Lys-Thr-Cys(1)-Thr-ol; DOTA-D-Phenylalanyl-L-cysteinyl-3-(1-naphthalenyl)-L-alanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol (2->7)-disulfide. Grade: 95%. CAS No. 619300-53-7. Molecular formula: C69H94N14O17S2. Mole weight: 1455.70. | |
| DOTATATE | DOTATATE is a radiolabeled somatostatin analog used in medical imaging and therapy for neuroendocrine tumors (NETs). DOTATATE is a peptide derivative that binds selectively to somatostatin receptors (mainly subtype 2), which are overexpressed on the surface of neuroendocrine tumor cells. This allows for specific targeting of these tumors. Synonyms: L-Threonine, N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide; L-Threonine, N-[[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide; DOTA-octreotate; DOTA-TATE; DOTA-[Tyr3]-Octreotide Acid; DOTA-(Tyr3)-octreotate. Grade: ≥95%. CAS No. 177943-88-3. Molecular formula: C65H90N14O19S2. Mole weight: 1435.63. | |
| DOV-216,303 Free Base | DOV-216,303 is a reuptake inhibitor, inhibiting the reuptake of norepinephrine (NE), serotonin (5-HT), and dopamine (DA), the three neurotransmitters most closely linked to major depressive disorder. Synonyms: 1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane; DOV-216,303. Grade: 98%. CAS No. 66504-40-3. Molecular formula: C11H11Cl2N. Mole weight: 228.12. | |
| Dovitinib | Dovitinib (TKI258) potently inhibited FLT3, c-KIT, FGFR, VEGFR1/2/3, PDGFRß and CSF-1R with IC50 values of 1, 2, 5, 10, 8, 27, 36 nM respectively. Dovitinib selectively blocked the growth of wild-type (WT) or activated mutant FGFR3-transformed B9 cells and human myeloma cell lines. Dovitinib was an effective treatment in a xenograft mouse model of FGFR3 multiple myeloma. Synonyms: Dovitinib, TKI258; TKI 258; TKI-258; CHIR 265; CHIR265; CHIR-265; RAF-265; RAF 265; RAF265. Grade: > 95%. CAS No. 405169-16-6. Molecular formula: C21H21FN6O. Mole weight: 392.429. | |
| Dovitinib Dilactic Acid | Dovitinib is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGF-1R and HER2 in cell-free assays. Synonyms: Dovitinib Dilactic acid; TKI258 Dilactic acid; CHIR-258; CHIR 258; CHIR258; TKI258; TKI 258; TKI-258. Grade: >98%. CAS No. 852433-84-2. Molecular formula: C27H33FN6O7. Mole weight: 572.59. | |
| Dovitinib lactate | Dovitinib, also referred as CHIR-258 or TKI258, is a potent receptor tyrosine kinase inhibitor (TKI) that selectively targets VEGFR, PDGFR, FGFR, CSF1R, c-KIT, RET, TrKA, and FLT3, and additionally targets FGFR (IC50 = 5 nM). Synonyms: 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1,3-dihydrobenzimidazol-2-ylidene]quinolin-2-one; 2-hydroxypropanoic acid; 4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxypropanoate; Dovitinib(lactate); 4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxy; CTK8B6779. CAS No. 692737-80-7. Molecular formula: C24H27FN6O4. Mole weight: 482.51. | |
| Dovitinib Lactate Hydrate | Dovitinib lactate hydrate is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively. Synonyms: TKI258 lactate hydrate; CHIR-258 lactate hydrate; 4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxypropanoate hydrate; Propanoic acid, 2-hydroxy-, compd. with 4-amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone, hydrate (1:1:1). Grade: >98%. CAS No. 915769-50-5. Molecular formula: C24H29FN6O5. Mole weight: 500.52. | |
| Doxapram | Doxapram is a respiratory stimulant with analeptic activity. Administered intravenously, doxapram stimulates an increase in tidal volume, and respiratory rate. Doxapram stimulates chemoreceptors in the carotid bodies of the carotid arteries, which in turn, stimulates the respiratory centre in the brain stem. It has been used as a temporary measure in hospitalized patients with acute respiratory insufficiency superimposed on chronic obstructive pulmonary disease. Uses: Central nervous system stimulants; respiratory system agents. Synonyms: Dopram; 1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one; Doxapramum; AHR-619; AHR 619; AHR619. Grade: ≥98%. CAS No. 309-29-5. Molecular formula: C24H30N2O2. Mole weight: 378.51. | |
| Doxazosin | Doxazosin is a quinazoline-derivative and long-lasting α1 adrenergic receptor blocker. It inhibits the binding of norepinephrine, which is released from sympathetic nerve terminals, to the α-1 receptors on the membrane of vascular smooth muscle cells. It is widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms. It may have an inhibitory effect on cholesterol synthesis independent of the LDL receptor. It also shows high affinity to alpha-1c adrenoceptor which may partially attribute to its effect in treatment of benign prostatic hyperplasia. It has been found to help reduce the intensity of and/or stop posttraumatic stress disorder night terrors and nightmares. Synonyms: [4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2,5-dioxabi cyclo[4.4.0]deca-6,8,10-trien-4-yl)methanone; Piperazine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]-; UK 33274; Doxazosin; Cardura; Alfamedin. Grade: 98%. CAS No. 74191-85-8. Molecular formula: C23H25N5O5. Mole weight: 451.48. | |
| Doxazosin EP Impurity B monohydrochloride | Doxazosin impurity. Synonyms: 1-[(2,3-Dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine Monohydrochloride. Grade: > 95%. CAS No. 70918-74-0. Molecular formula: C13H17ClN2O3. Mole weight: 284.74. | |
| Doxazosin Mesylate | Doxazosin mesylate is an α1-selective alpha blocker used to treat high blood pressure and urinary retention associated with benign prostatic hyperplasia. Grade: 98%. CAS No. 77883-43-3. Molecular formula: C24H29N5O8S. Mole weight: 547.58. | |
| Doxercalciferol | Doxercalciferol is a Vitamin D2 analog that acts as a vitamin D receptor activator (VDRA). Synonyms: Hectorol; 1-Hydroxyergocalciferol; 1alpha-Hydroxyergocalciferol; 1-alpha-Hydroxyvitamin D2. Grade: 98%. CAS No. 54573-75-0. Molecular formula: C28H44O2. Mole weight: 412.65. | |
| Doxercalciferol-13C-d3 | One of the isotopic labelled impurities of Vitamin D2, which could be effective as an antirachitic agent. Synonyms: (1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,2E)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol-13C-d3. Molecular formula: C27[13C]H41O2. Mole weight: 416.67. | |
| D-Oxime Ribose | D-Oxime Ribose is a D-Ribose derivative, and it is useful in the synthesis of riboflavin derivatives. Synonyms: Oxime Ribose; NSC 37845; D-Ribose, oxime; D-Ribose oxime. CAS No. 6272-50-0. Molecular formula: C5H11NO5. Mole weight: 165.14. | |
| Doxofylline | Doxofylline is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma. Uses: Antitussive agents. Synonyms: Doxofylline; Ansimar; ABC-12-3; ABC-1213; ALT-07; DO-309; ABC 12 3; ABC 1213; ALT 07; DO 309; ABC12; 3; ABC1213; ALT07; DO309. Grade: >98%. CAS No. 69975-86-6. Molecular formula: C11H14N4O4. Mole weight: 266.25. | |
| Doxofylline Impurity 1 | Doxofylline Impurity 1 is a Doxofylline impurity. Doxofylline is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma. Synonyms: 1-(1,3-Dioxolan-2-ylmethyl)-N-methyl-4-(methylamino)-1H-imidazole-5-carboxamide. Grade: > 95%. CAS No. 1429636-74-7. Molecular formula: C10H16N4O3. Mole weight: 240.26. | |
| Doxofylline Impurity 10 | Doxofylline Impurity 10 is a Doxofylline impurity. Doxofylline is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma. Synonyms: ethyl 7-theophyllineacetate; (1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)-acetic acid ethyl ester. CAS No. 7029-96-1. Molecular formula: C11H14N4O4. Mole weight: 266.25. | |
| Doxofylline Impurity 11 | Doxofylline Impurity 11 is a Doxofylline impurity. Doxofylline is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma. CAS No. 109403-76-1. Molecular formula: C15H16N8O4. Mole weight: 372.34. | |
| Doxofylline Impurity 12 | Doxofylline Impurity 12 is a Doxofylline impurity. Doxofylline is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma. Synonyms: Doxofylline Impurity B. CAS No. 254760-82-2. Molecular formula: C11H16N4O4. Mole weight: 268.27. | |
| Doxofylline Impurity 14 | Doxofylline Impurity 14 is a Doxofylline impurity. Doxofylline is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma. Molecular formula: C12H18N4O5. Mole weight: 298.29. | |
| Doxofylline Impurity 2 | Doxofylline Impurity 2 (Theophylline Impurity 2) is a Doxofylline impurity. Doxofylline is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma. Synonyms: Theophylline Impurity 1; 1,2,3,6-Tetrahydro-1,3-dimethyl-2,6-dioxopurine-7-acetaldehyde; 7-(Formylmethyl)theophylline; 7-Theophyllineacetaldehyde. Grade: > 95%. CAS No. 5614-53-9. Molecular formula: C9H10N4O3. Mole weight: 222.20. | |
| Doxofylline Impurity 4 | Doxofylline Impurity 4 is a Doxofylline impurity. Doxofylline is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma. Synonyms: 1-((1,3-Dioxolan-2-yl)methyl)-4-(1,3-dimethylureido)-1H-imidazole-5-carboxylic Acid; 2095554-12-2; F95323. Grade: >98%. CAS No. 2095554-12-2. Molecular formula: C11H16N4O5. Mole weight: 284.27. | |
| Doxofylline Impurity 5 | Doxofylline Impurity 5 is a Doxofylline impurity. Doxofylline is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma. Synonyms: 2,4(1H,3H)-Dione, 1,3-dimethyl-6,7,9,10-tetrahydro-7,10-epoxy[1,4]oxazepino[5,4-f]purine-. Grade: >98%. Molecular formula: C11H12N4O4. Mole weight: 264.24. | |
| Doxofylline Impurity 6 | Doxofylline Impurity 6 is a Doxofylline impurity. Doxofylline is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma. Grade: >98%. CAS No. 1429636-72-5. Molecular formula: C11H16N4O4. Mole weight: 268.27. | |
| Doxofylline Impurity 7 | Doxofylline Impurity 7 is a Doxofylline impurity. Doxofylline is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma. Grade: >98%. Molecular formula: C10H14N4O5. Mole weight: 270.24. | |
| Doxofylline Impurity 8 | Doxofylline Impurity 8 is a Doxofylline impurity. Doxofylline is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma. Molecular formula: C9H13N3O4. Mole weight: 227.22. | |
| Doxofylline Impurity 9 | Doxofylline Impurity 9 is a Doxofylline impurity. Doxofylline is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma. Synonyms: 7-(2',2'-Diethoxyethyl)theophylline1111. CAS No. 43135-57-5. Molecular formula: C13H20N4O4. Mole weight: 296.32. | |
| Doxofylline Related Compound D | Doxofylline Related Compound D is a Doxofylline impurity. Doxofylline is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma. Grade: >98%. Molecular formula: C9H14N4O5. Mole weight: 258.23. | |
| Doxorubicin Dimer Impurity 1 | Doxorubicin Dimer Impurity 1 is an impurity of Doxorubicin, which is an anthracycline antibiotic with anti-Gram-positive bacterial activity and a broad antitumor spectrum. Synonyms: (8S,10S)-10-(((2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(((2S,3S,4S,6R)-3-hydroxy-2-methyl-6-(((1S,3S)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl)oxy)tetrahydro-2H-pyran-4-yl)glycyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione. Grade: ≥95%. Molecular formula: C54H56N2O21. Mole weight: 1069.05. | |
| Doxorubicin Dimer Impurity 2 | Doxorubicin Dimer Impurity 2 is an impurity of Doxorubicin, which is an anthracycline antibiotic with anti-Gram-positive bacterial activity and a broad antitumor spectrum. Molecular formula: C44H46N2O16. Mole weight: 858.86. | |
| Doxorubicin Dimer Impurity 3 | Doxorubicin Dimer Impurity 3 is an impurity of Doxorubicin, which is an anthracycline antibiotic with anti-Gram-positive bacterial activity and a broad antitumor spectrum. Synonyms: (8S,8'S,10S,10'S)-8,8'-(4-Hydroxy-2-(hydroxymethyl)-1,3-dioxolane-2,4-diyl)bis(10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione); (R,S,S,S,8S,8'S,10S,10'S)-8,8'-(4-hydroxy-2-(hydroxymethyl)-1,3-dioxolane-2,4-diyl)bis(10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione). Molecular formula: C54H58N2O22. Mole weight: 1087.05. | |
| Doxorubicin EP Impurity B | Doxorubicin EP Impurity B is an impurity of Doxorubicin, which is an anthracycline antibiotic with anti-Gram-positive bacterial activity and a broad antitumor spectrum. Synonyms: Doxorubicin Impurity B; Doxorubicin Ketal Impurity; (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-(2-bromo-1,1-dimethoxyethyl)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione; 14-bromine-13-dimethyl-actone-4'-daunorubicin; Doxorubicin EP Impurity B; (1S,3S)-3-(2-Bromo-1,1-dimethoxyethyl)-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside; (8S-cis)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-(2-bromo-1,1-dimethoxyethyl)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione; 14-Bromo Ketal Daunorubicin; Daunorubicin bromoketal. Grade: 85%. CAS No. 106401-68-7. Molecular formula: C29H34BrNO11. Mole weight: 652.48. | |
| Doxorubicin EP Impurity C hydrobromide dihydrate | Doxorubicin EP Impurity C hydrobromide dihydrate is an impurity of Doxorubicin, which is an anthracycline antibiotic with anti-Gram-positive bacterial activity and a broad antitumor spectrum. Synonyms: (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-(bromoacetyl)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione dihydrate hydrobromide; (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-(2-bromoacetyl)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione dihydrate Hydrobromide; 14-Bromodaunomycin dihydrate Hydrobromide Salt; 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-8-(bromoacetyl)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)-, hydrate, Hydrobromide (1:2:1); 14-Bromodaunorubicin dihydrate Hydrobromide. Molecular formula: C27H28BrNO10.2H2O.HBr. Mole weight: 723.36. | |
| Doxorubicin Impurity 1 | Doxorubicin Impurity 1 is an impurity of Doxorubicin, which is an anthracycline antibiotic with anti-Gram-positive bacterial activity and a broad antitumor spectrum. Synonyms: Doxorubicin Impurity; 6,8,10,11-Tetrahydroxy-1-methoxy-5,12-naphthacenedione; 7,8-Desacetyl-9,10-dehydro Daunorubicinone; 5,12-Naphthacenedione, 6,8,10,11-tetrahydroxy-1-methoxy-; Xanthone Impurity 13. Grade: > 95%. CAS No. 1159977-24-8. Molecular formula: C19H12O7. Mole weight: 352.29. | |
| Doxorubicin Impurity 10 | Doxorubicin Impurity 10 is an impurity of Doxorubicin, which is an anthracycline antibiotic with anti-Gram-positive bacterial activity and a broad antitumor spectrum. Molecular formula: C21H17ClO8. Mole weight: 432.82. | |
| Doxorubicin Impurity 13 | Doxorubicin Impurity 13 is an impurity of Doxorubicin, which is an anthracycline antibiotic with anti-Gram-positive bacterial activity and a broad antitumor spectrum. Synonyms: (8R,10S)-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,7,8,11-tetrahydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione. Molecular formula: C27H29NO12. Mole weight: 559.52. | |
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