BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Enalaprilat Dehydrate EP Impurity B | An impurity of Enalaprilat. Enalaprilat is the active metabolite of enalapril. Enalapril is an angiotensin-converting-enzyme inhibitor used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. Synonyms: (1R)-2-((R)-2-(((R)-4-oxo-1-phenylpentan-3-yl)amino)propanoyl) pyrrolidine-2-carboxylic acid. Grade: > 95%. Molecular formula: C18H24N2O5. Mole weight: 348.40. |  |
| Enalaprilat Dehydrate EP Impurity C | An impurity of Enalaprilat. Enalaprilat is the active metabolite of enalapril. Enalapril is an angiotensin-converting-enzyme inhibitor used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. Synonyms: (1R)-2-((R)-2-(((R)-4-oxo-1-phenylpentan-3-yl)amino)propanoyl)pyrrolidine-2-carboxylic acid. Grade: > 95%. Molecular formula: C18H24N2O5. Mole weight: 348.40. | |
| Enalaprilat Dehydrate EP Impurity D | An impurity of Enalaprilat. Enalaprilat is the active metabolite of enalapril. Enalapril is an angiotensin-converting-enzyme inhibitor used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. Synonyms: (1R)-2-((R)-2-(((R)-4-oxo-1-phenylpentan-3-yl)amino)propanoyl)pyrrolidine-2-carboxylic acid. Grade: > 95%. Molecular formula: C18H24N2O5. Mole weight: 348.40. | |
| Enalaprilat Dehydrate EP Impurity E | An impurity of Enalaprilat. Enalaprilat is the active metabolite of enalapril. Enalapril is an angiotensin-converting-enzyme inhibitor used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. Synonyms: (S)-1-((S)-1-((S)-2-(((S)-4-oxo-1-phenylpentan-3-yl)amino)propanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylic acid. Grade: > 95%. Molecular formula: C23H31N3O6. Mole weight: 445.52. | |
| Enalaprilat Dehydrate EP Impurity F | An impurity of Enalaprilat. Enalaprilat is the active metabolite of enalapril. Enalapril is an angiotensin-converting-enzyme inhibitor used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. Synonyms: (S)-ethyl 2-(((S)-3-hydroxybut-3-en-2-yl)amino)-4-phenylbutanoate. Grade: > 95%. Molecular formula: C15H21NO4. Mole weight: 279.34. | |
| Enalaprilat Dihydrate | Enalaprilat is the active metabolite of enalapril. It is the first dicarboxylate-containing ACE inhibitor. Grade: >98%. CAS No. 84680-54-6. Molecular formula: C18H28N2O7. Mole weight: 384.42. | |
| Enalaprilat N-Glucuronide | An impurity of Enalapril. Enalapril is an angiotensin-converting-enzyme inhibitor used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. Synonyms: (S)-1-((S)-2-(((2R,3R,4S,5S,6S)-6-Carboxy-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)((S)-1-carboxy-3-phenylpropyl)amino)propanoyl)pyrrolidine-2-carboxylic Acid. Grade: > 95%. Molecular formula: C24H32N2O11. Mole weight: 524.53. | |
| Enalapril Diketopiperazine Acid | An impurity of Enalapril. Enalapril is an angiotensin-converting-enzyme inhibitor used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. Synonyms: (αS,3S,8aS)-Hexahydro-3-methyl-1,4-dioxo-α-(2-phenylethyl)pyrrolo[1,2-a]pyrazine-2(1H)-acetic acid; (S)-2-((3S,8aS)-3-Methyl-1,4-dioxohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-4-phenylbutanoic acid; Enalapril Maleate Impurity 2; [3S-[2(R*),3α,8aβ]]-Hexahydro-3-methyl-1,4-dioxo-α-(2-phenylethyl)pyrrolo[1,2-a]pyrazine-2(1H)-acetic acid. Grade: ≥95%. CAS No. 115623-21-7. Molecular formula: C18H22N2O4. Mole weight: 330.38. | |
| Enalapril EP Impurity A (SSR) | An impurity of Enalapril. Enalapril is an angiotensin-converting-enzyme inhibitor used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. Synonyms: (R,S,S)-Enalapril Maleate.N-[(1R)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-L-proline (2Z)-2-Butenedioate. Grade: > 95%. CAS No. 1356932-13-2. Molecular formula: C20H28N2O5. Mole weight: 376.46. | |
| Enalapril EP Impurity D | An impurity of Enalapril. Enalapril is an angiotensin-converting-enzyme inhibitor used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. Synonyms: Enalapril diketopiperazine; Ethyl (2S)-2-[(3S,8aS)-3-methyl-1,4-dioxooctahydropyrrolo [1,2-a]pyrazin-2-yl]-4-phenylbutanoate. Grade: > 95%. CAS No. 115729-52-7. Molecular formula: C20H26N2O4. Mole weight: 358.44. | |
| Enalapril EP Impurity E Maleate | An impurity of Enalapril. Enalapril is an angiotensin-converting-enzyme inhibitor used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. Synonyms: (2S)-1-[(2S)-2-[[(1S)-3-Phenyl-1-[(2-phenylethoxy)carbonyl]propyl]amino]propanoyl]pyrrolidine-2-carboxylic acid Maleate. Grade: > 95%. Molecular formula: C26H32N2O5. C4H4O4. Mole weight: 452.56 116.07. | |
| Enalapril EP Impurity F | An impurity of Enalapril. Enalapril is an angiotensin-converting-enzyme inhibitor used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. Synonyms: (2S)-1-[(2S)-2-[[(1S)-1-(Butoxycarbonyl)-3- phenylpropyl]amino]propanoyl]pyrrolidine-2-carboxylic acid hydrochloride. Grade: > 95%. CAS No. 76420-77-4. Molecular formula: C22H32N2O5. Mole weight: 404.51. | |
| Enalapril EP Impurity G | An impurity of Enalapril. Enalapril is an angiotensin-converting-enzyme inhibitor used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. Synonyms: (2S)-2-[[(1S)-3-Cyclohexyl-1-(ethoxycarbonyl)propyl]amino] propanoic acid. Grade: > 95%. CAS No. 460720-14-3. Molecular formula: C15H27NO4. Mole weight: 285.39. | |
| Enalapril EP Impurity H | An impurity of Enalapril. Enalapril is an angiotensin-converting-enzyme inhibitor used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. Synonyms: (2S)-1-[(2S)-2-[[(1S)-3-Cyclohexyl-1-(ethoxycarbonyl)propyl] amino]propanoyl]pyrrolidine-2-carboxylic acid ; C20H34N2O5. Grade: > 95%. Molecular formula: C20H34N2O5. Mole weight: 382.50. | |
| Enalapril Impurity 1 | An impurity of Enalapril. Enalapril is an angiotensin-converting-enzyme inhibitor used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. Synonyms: Benzenebutanoic acid, α-[(1-carboxyethyl)amino]-γ-oxo-, monoethyl ester, [R-(R*,S*)]-; [R-(R*,S*)]-α-[(1-Carboxyethyl)amino]-γ-oxo-benzenebutanoic Acid Monoethyl Ester; N-[(1R)-1-Carboxyethyl]-4-oxo-4-phenyl-L-homoalanine ethyl ester; 1R-Carboxyethyl-Asp(Ph)-OEt; ((S)-1-Ethoxy-1,4-dioxo-4-phenylbutan-2-yl)-D-alanine. Grade: ≥95%. CAS No. 105167-27-9. Molecular formula: C15H19NO5. Mole weight: 293.32. | |
| Enalapril N-Glucuronide | An impurity of Enalapril. Enalapril is an angiotensin-converting-enzyme inhibitor used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. Synonyms: (S)-1-((S)-2-(((2R,3R,4S,5S,6S)-6-Carboxy-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)pyrrolidine-2-carboxylic Acid. Grade: > 95%. Molecular formula: C26H36N2O11. Mole weight: 552.58. | |
| Enalkiren | Enalkiren: Introducing Enalkiren is an efficacious and exclusive suppressor of human renin, a pivotal enzyme within the renin-angiotensin-aldosterone system. Its indispensable role lies in studying hypertension (increased blood pressure) and congestive heart failure. Uses: Protease inhibitors. Synonyms: Enalquireno; Enalkirene; 3-amino-N-[(2S)-1-[[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-(4-methoxyphenyl)-1-oxopropan-2-yl]-3-methylbutanamide. CAS No. 113082-98-7. Molecular formula: C35H56N6O6. Mole weight: 656.86. | |
| Enarodustat | Enarodustat is an orally active HIF prolyl hydroxylase inhibitor. Enarodustat has been used for the treatment of anemia, especially when associated with chronic kidney disease (CKD). Synonyms: JTZ-951. CAS No. 1262132-81-9. Molecular formula: C17H16N4O4. Mole weight: 340.33. | |
| Enasidenib | Enasidenib, aslo known as AG-221 and CC-90007, is a potent and selective IDH2 inhibitor with potential anticancer activity (IDH2 = Isocitrate dehydrogenase 2). Synonyms: AG-221; AG 221; AG221; CC-90007; CC 90007; CC90007; Enasidenib. Grade: 98%. CAS No. 1446502-11-9. Molecular formula: C19H17F6N7O. Mole weight: 473.38. | |
| Enasidenib mesylate | Enasidenib mesylate is a first-in-class, oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes indicated for the treatment of adult patients with replased or refractory acute myeloid leukemia (AML) with an isocitrate dehydrogenase-2 (IDH2) mutation. Synonyms: methanesulfonic acid; 2-methyl-1-[[4-[6-(trifluoromethyl)pyridin-2-yl]-6-[[2-(trifluoromethyl)pyridin-4-yl]amino]-1,3,5-triazin-2-yl]amino]propan-2-ol; Enasidenib (mesylate); AG-221 mesylate; Enasidenib mesilate; Enasidenib methanesulfonate; Enasidenib mesylate [USAN]. CAS No. 1650550-25-6. Molecular formula: C20H21F6N7O4S. Mole weight: 569.48. | |
| Enavogliflozin | Enavogliflozin is an antidiabetic agent, and selective sodium-glucose cotransporter-2 (SGLT-2) inhibitor. Synonyms: DWP-16001. CAS No. 1415472-28-4. Molecular formula: C24H27ClO6. Mole weight: 446.92. | |
| Enazadrem phosphate | Enazadrem phosphate is a 5-lipoxygenase inhibitor as an Antipsoriatic agent. Uses: Antipsoriatic agent. Synonyms: UNII-93VML10KA9; ENAZADREM PHOSPHATE; Enazadrem phosphate (USAN); Enazadrem phosphate [USAN]; SCHEMBL219332; 93VML10KA9; D03990; 4,6-Dimethyl-2-((6-phenylhexyl)amino)-5-pyrimidinol phosphate (1:1) (salt); 107361-33-1(base). Grade: 98%. CAS No. 132956-22-0. Molecular formula: C18H28N3O5P. Mole weight: 397.41. | |
| Enbezotinib | Enbezotinib is an inhibitor of RET. Enbezotinib can inhibit the RET autophosphorylation. CAS No. 2359649-81-1. Molecular formula: C21H21FN6O3. Mole weight: 424.43. | |
| Encainide Hydrochloride | Encainide Hydrochloride is a sodium channel blocker and class Ic antiarrhythmic agent. It is a non-chiral and benzanilide derivative. It blocks voltage-gated sodium channels and slows conduction within the His-Purkinje system and myocardium. It has antifibrillatory activity. It was developed by Bristol-Myers Squibb and is no longer used because of its frequent proarrhythmic side effects. Uses: Encainide hydrochloride is a sodium channel blocker and class ic antiarrhythmic agent. Synonyms: Encainide HCl; MJ9067 hydrochloride; MJ-9067 hydrochloride; 4-Methoxy-N-[2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl]benzamide hydrochloride; 4-Methoxy-2'-(2-(1-methyl-2-piperidyl)ethyl)benzanilide hydrochloride. Grade: 98%. CAS No. 66794-74-9. Molecular formula: C22H29ClN2O2. Mole weight: 388.94. | |
| Encaleret | Encaleret is a calcium-sensing receptor (CaSR) antagonist. But in Oct 2011, Phase-II for Osteoporosis in USA was discontinued. Uses: Osteoporosis. Synonyms: 1214922-52-7 (sulfate salt); JIT-305; JIT 305; JIT305; 2'-((R)-1-((R)-3-((1-(4-chloro-3-fluorophenyl)-2-methylpropan-2-yl)amino)-2-hydroxypropoxy)ethyl)-3-methyl-[1,1'-biphenyl]-4-carboxylic acid. Grade: 98%. CAS No. 787583-71-5. Molecular formula: C29H33ClFNO4. Mole weight: 514.03. | |
| ENCALERET SULFATE | This active molecular is an CaSR (calcium-sensing receptor antagonist) under the developmet of Tobacco and Merck & Co. Calcium-sensing receptor is a member of the G protein-coupled receptor and it is very important to modulate Ca2+ homeostasis via its role in the parathyroid glands and kidneys. Encaleret was used for the treatment of osteoporosis., but was discontinued in Phase-II in Japan, India and USA in 2011. Uses: The treatment of osteoporosis. Synonyms: 4-[2-[(1R)-1-[(2R)-3-[[1-(4-chloro-3-fluorophenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]phenyl]-2-methylbenzoic acid; sulfuric acid; hydrate; JIT305; JIT 305; JIT-305. Grade: 98%. CAS No. 1214922-52-7. Molecular formula: C58H70Cl2F2N2O13S. Mole weight: 1144.16. | |
| Encenicline, HCl salt | EVP-6124, its alpha-7 nicotinic acetylcholine receptor agonist, possesses a novel mechanism not previously seen in the scientific community: it acts as a co-agonist with Acetylcholine (ACh) to enhance cognition. By acting as a co-agonist and sensitizing the alpha-7 receptor, EVP-6124 makes it possible for smaller amounts of naturally occurring ACh, typically found in individuals with memory disorders such as Alzheimer's, to be required to activate the receptor. In this scenario, research demonstrated that memory deficits can be minimized or entirely reversed by controlling the neuronal channel with EVP-6124 alone or in combination with other Alzheimer's drugs. Synonyms: EVP-6124; EVP 6124; EVP6124; MT-4666; MT 4666; MT4666; Encenicline. IUPAC/Chemical name:(R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride. Grade: 0.98. CAS No. 550999-74-1. Molecular formula: C16H18Cl2N2OS. Mole weight: 357.293. | |
| Encorafenib | Encorafenib, also known as LGX-818, is an orally available Raf kinase inhibitor with potential antineoplastic activity. LGX818 specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of LGX818 may result in a decrease in proliferation of tumor cells. The Raf mutation BRAF V600E is frequently upregulated in a variety of human tumors and results in the constitutive activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival. Synonyms: LGX818; LGX-818; LGX 818; Methyl N-[(2S)-1-[[4-[3-[5-chloro-2-fluoro-3-(methanesulfonamido)phenyl]-1-propan-2-ylpyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate. Grade: ≥98%. CAS No. 1269440-17-6. Molecular formula: C22H27ClFN7O4S. Mole weight: 540.011. | |
| Endo-3-D-Pal-Cetrorelix | Endo-3-D-Pal-Cetrorelix is an impurity of Cetrorelix, which is a gonadotropin-releasing hormone antagonist used in the treatment of prostate and breast cancers. Synonyms: Ac-D-2Nal-D-Phe(4-Cl)-D-3-Pal-D-3-Pal-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2; N-acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-3-(3-pyridyl)-D-alanyl-L-seryl-L-tyrosyl-D-citrullyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide. Molecular formula: C78H100ClN19O15. Mole weight: 1579.23. | |
| Endo-Ala18-Liraglutide | Endo-Ala18-Liraglutide is a derivative of Liraglutide, a long-acting analog of glucagon-like peptide-1 (GLP-1) receptor which could protect b-cells from apoptosis under conditions associated with the development of type 1 and type 2 diabetes. Synonyms: H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Ala-Lys(Gamma-Glu-palmitoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH. Molecular formula: C175H270N44O52. Mole weight: 3822.36. | |
| Endochin | Endochin is an experimental antimalarial which was known to be causal prophylactic and potent erythrocytic stage agents in avian models. Uses: Be causal prophylactic and potent erythrocytic stage agents in avian models. Synonyms: 3-heptyl-7-methoxy-2-methylquinolin-4(1H)-one. Grade: ≥98%. CAS No. 354155-51-4. Molecular formula: C18H25NO2. Mole weight: 287.18. | |
| Endo-Gly31-Liraglutide | Endo-Gly31-Liraglutide is a derivative of Liraglutide, a long-acting analog of glucagon-like peptide-1 (GLP-1) receptor which could protect b-cells from apoptosis under conditions associated with the development of type 1 and type 2 diabetes. Synonyms: H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(Gamma-Glu-palmitoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-Gly-OH. Molecular formula: C174H268N44O52. Mole weight: 3808.31. | |
| Endo-Gly-AVP | Endo-Gly-AVP is an impurity of Vasopressin, which is an antidiuretic hormone secreted from the posterior pituitary. Synonyms: Di-Gly-Argipressin; Endo-Gly-Vasopressin; Vasopressin, 8-L-arginine-8a-endo-glycine-; H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-Gly-NH2 (Disulfide bridge: Cys1-Cys6); L-Cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparagyl-L-cysteinyl-L-prolyl-L-arginylglycyl-glycinamide (1->6)-disulfide; Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-Gly-NH2(Cys1&Cys6 bridge); CYFQNCPRGG-NH2(Cys1&Cys6 bridge). Grade: ≥95%. CAS No. 77403-94-2. Molecular formula: C48H68N16O13S2. Mole weight: 1141.29. | |
| Endomorphin 1 trifluoroacetate salt | Endomorphin 1, an endogenous neuropeptide, is found in the brain and, to a lesser extent, in the spinal cord. It is an agonist of μ-opioid receptor (Ki = 0.36 nM) that has analgesic, positive reinforcing, and gastrointestinal properties, which is selective for μ- over δ- and κ-opioid receptors (Ki = 1,506 and 5,428 nM, respectively). Synonyms: L-tyrosyl-L-prolyl-L-tryptophyl-L-phenylalaninamide, trifluoroacetate salt. Grade: ≥95%. Molecular formula: C34H38N6O5·xCF3COOH. Mole weight: 610.70. | |
| Endomorphin 2 TFA | Endomorphin 2 TFA is a high affinity, highly selective agonist of the μ-opioid receptor. It displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM. Synonyms: Endomorphin 2 (TFA); Endomorphin-2 Trifluoroacetate; L-tyrosyl-L-prolyl-L-phenylalanyl-L-phenylalaninamide,trifluoroacetatesalt. Grade: 99%. CAS No. 1276124-00-5. Molecular formula: C34H38F3N5O7. Mole weight: 685.69. | |
| Endomorphin 2 trifluoroacetate salt | Endomorphin 2, an endogenous neuropeptide, is found in the spinal cord and, to a lesser extent, in the brain. It is an agonist of μ-opioid receptor (Ki = 0.69 nM) that has analgesic, negative reinforcing, and gastrointestinal properties, which is selective for μ- over δ- and κ-opioid receptors (Kis = 9,233 and 5,240 nM, respectively). Synonyms: L-tyrosyl-L-prolyl-L-phenylalanyl-L-phenylalaninamide, trifluoroacetate salt. Grade: ≥95%. Molecular formula: C32H37N5O5·xCF3COOH. Mole weight: 571.67. | |
| Endosidin 2 | Endosidin 2 (ES2) is a cell-permeable benzylidene-benzohydrazide that binds to EXO70 subunit of the exocyst complex which results in inhibition of exocytosis and endosomal recycling in both plant and human cells and enhancement of plant vacuolar trafficking. Synonyms: ES2; 3-fluoro-benzoic acid, (2E)-2-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylene]hydrazide; (E)-3-Fluoro-N'-(4-hydroxy-3-iodo-5-methoxybenzylidene)benzohydrazide. Grade: ≥98%. CAS No. 1839524-44-5. Molecular formula: C15H12FIN2O3. Mole weight: 414.2. | |
| Endothelin-1 (human, porcine) trifluoroacetate salt | Endothelin-1 is a peptide vasoconstrictor that in humans is encoded by the EDN1 gene and produced by vascular endothelial cells. It is an agonist of endothelin (ET) receptors ETA and ETB (IC50s = 0.15 and 0.12 nM, respectively). Synonyms: ET-1. Grade: ≥95%. Molecular formula: C109H159N25O32S5·xCF3COOH. Mole weight: 2491.91. | |
| Endothelin 1 (swine), big | Endothelin 1 (swine), big is a precursor of endothelin-1 and has a similar pressor effect in vivo. Endothelin-1 (ET-1) is a potent vasopressor peptide. Synonyms: 33,34,49,50-Tetrathia-2,5,8,11,14,17,20,23,26,29,37,40,43,46-tetradecaazabicyclo[23.22.4]henpentacontane, cyclic peptide deriv.; Endothelin 1 (pig), big; Big porcine endothelin(1-39); Endothelin-39 (pig); Human proendothelin-1; Porcine big endothelin; Porcine big endothelin(1-39); Porcine big endothelin-1; Porcine proendothelin(1-39); Big Endothelin-1 (1-39), porcine; H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Ile-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Ser-Arg-Ser-OH (Disulfide bridge: Cys1-Cys15, Cys3-Cys11). CAS No. 120796-99-8. Molecular formula: C193H289N49O58S5. Mole weight: 4383.97. | |
| Endothelin 1 (swine, human) acetate | Endothelin 1 (swine, human), a vasoconstrictor increased in plasma and explants of patients with uterine leiomyomas, is a synthetic peptide with the sequence of human and swine Endothelin 1 and acts through two types of receptors ETA and ETB. Molecular formula: C111H163N25O34S5. Mole weight: 2551.95. | |
| Endothelin-2 (human) trifluoroacetate salt | Endothelin-2 is a secretory peptide vasoconstrictor and ligand for the endothelin (ET) receptors ETA and ETB (Kbs= 32.8 and 1.33 nM, respectively). It displays similar selectivity for ETA and ETB endothelin receptors. Synonyms: ET-2. Grade: ≥95%. Molecular formula: C115H160N26O32S4·xCF3COOH. Mole weight: 2546.92. | |
| Endotoxin Inhibitor acetate | Endotoxin inhibitor bears a structural resemblance to the peptide antibiotic and endotoxin inhibitor polymyxin B. It could be of use as an adjuvant for antibiotic therapy. Molecular formula: C57H101N15O14S2. Mole weight: 1284.65. | |
| Endovion | Endovion is a pharmacological anion channe inhibitor and a volume regulated anion channel (VRAC) blocker. Synonyms: SCO-101; NS 3728; NS-3728; NS3728. CAS No. 265646-85-3. Molecular formula: C16H9BrF6N6O. Mole weight: 495.18. | |
| Endoxifen E-isomer hydrochloride | The hydrochloride salt form of E-isomer of Endoxifen which is a significant metamolite of Tamoxifen, could be a regulator of estrogen receptor and could be effective in the treatment of estrogen-dependent breast cancer. Uses: The hydrochloride salt form of e-isomer of endoxifen which could be a regulator of estrogen receptor and could be effective in the treatment of estrogen-dependent breast cancer. Synonyms: E-Endoxifen hydrochloride. Grade: 98%. CAS No. 1197194-61-8. Molecular formula: C25H28ClNO2. Mole weight: 409.95. | |
| Endoxifen HCl | Endoxifen HCl, the active metabolite of Tamoxifen, ia a potent and selective estrogen receptor antagonist. Phase 2. Endoxifen shows anti-estrogenic effects, and decreases the E2-induced PR expression in MCF-7 cells. In vivo, Endoxifen (8 mg/kg, ) inhibits growth of MCF-7 human mammary tumor xenografts in mice. Synonyms: Z-Endoxifen HCl; Z Endoxifen HCl; ZEndoxifen HCl; Z Endoxifen Hydrochloride; ZEndoxifen Hydrochloride. Grade: 98%. CAS No. 1032008-74-4. Molecular formula: C25H28ClNO2. Mole weight: 409.95. | |
| Endoxifen hydrochloride | Endoxifen hydrochloride is a metabolite of Tamoxifen and a selective estrogen receptor modulator (SERM) that inhibits the growth of estrogen-stimulated BT474 cells (IC50 = 54 nM). Endoxifen is used for the treatment of estrogen receptor (ER) positive breast cancer. Uses: Anticancer drug. Synonyms: 4-[1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-Phenol hydrochloride (1:1). Grade: 99%. CAS No. 1197194-41-4. Molecular formula: C25H28ClNO2. Mole weight: 409.95. | |
| Enerisant | This active molecular is a histamine H3 receptor antagonist. The IC50 of Enerisant is 4.9 nM in H3 receptor binding assay using (R)-α-methyl[3H]histamine. In the future, Enerisant may be able to applicate to the treatment of Alzheimer's disease, schizophrenia and so on. Uses: The treatment of alzheimer's disease, schizophrenia and so on. Synonyms: [1-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]pyrazol-4-yl]-morpholin-4-ylmethanone. Grade: 98%. CAS No. 1152747-82-4. Molecular formula: C22H30N4O3. Mole weight: 398.51. | |
| Enflicoxib | Enflicoxib is a non-steroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2 (COX-2), but does not inhibit cyclooxygenase-1 (COX-1). It has anti-inflammatory, analgesic and antipyretic activities in animal models. Synonyms: E 6087; Benzenesulfonamide, 4-[5-(2,4-difluorophenyl)-4,5-dihydro-3-(trifluoromethyl)-1H-pyrazol-1-yl]-; 1-(4-Aminosulfonylphenyl)-5-(2,4-difluorophenyl)-4,5-dihydro-3-trifluoromethyl-1H-pyrazole; 4-(5-(2,4-difluorophenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide. Grade: ≥98%. CAS No. 251442-94-1. Molecular formula: C16H12F5N3O2S. Mole weight: 405.34. | |
| Enfortumab | Enfortumab is a monoclonal antibody targeting Nectin-4. Enfortumab has been used for the treatment of urothelial cancer. CAS No. 1448664-46-7. | |
| Enfuvirtide Acetate | Enfuvirtide (T20; DP178) acetate is an anti-HIV-1 fusion inhibitor peptide. Uses: An antiretroviral drug used to treat hiv infection. Synonyms: L-Phenylalaninamide, N-acetyl-L-tyrosyl-L-threonyl-L-seryl-L-leucyl-L-isoleucyl-L-histidyl-L-seryl-L-leucyl-L-isoleucyl-L-α-glutamyl-L-α-glutamyl-L-seryl-L-glutaminyl-L-asparaginyl-L-glutaminyl-L-glutaminyl-L-α-glutamyl-L-lysyl-L-asparaginyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-leucyl-L-leucyl-L-α-glutamyl-L-leucyl-L-α-aspartyl-L-lysyl-L-tryptophyl-L-alanyl-L-seryl-L-leucyl-L-tryptophyl-L-asparaginyl-L-tryptophyl-, acetate; Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2.CH3CO2H; N-acetyl-L-tyrosyl-L-threonyl-L-seryl-L-leucyl-L-isoleucyl-L-histidyl-L-seryl-L-leucyl-L-isoleucyl-L-alpha-glutamyl-L-alpha-glutamyl-L-seryl-L-glutaminyl-L-asparagyl-L-glutaminyl-L-glutaminyl-L-alpha-glutamyl-L-lysyl-L-asparagyl-L-alpha-glutamyl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-leucyl-L-alpha-glutamyl-L-leucyl-L-alpha-aspartyl-L-lysyl-L-tryptophyl-L-alanyl-L-seryl-L-leucyl-L-tryptophyl-L-asparagyl-L-tryptophyl-L-phenylalaninamide acetic acid. Grade: ≥98%. CAS No. 914454-00-5. Molecular formula: C206H305N51O66. Mole weight: 4552.62. | |
| Englitazone sodium | Englitazone sodium is a novel blocker of NSCa and KATP channels. It is an antidiabetic agent. Uses: Englitazone sodium is an antidiabetic agent. Synonyms: CP-72467-2; CP72467-2; (-)-5-(((2R)-2-Benzyl-6-chromanyl)methyl)-2,4-thiazolidinedione, sodium salt; Sodium; 5-[[(2R)-2-benzyl-3,4-dihydro-2H-chromen-6-yl]methyl]-1,3-thiazolidin-3-ide-2,4-dione; 2,4-Thiazolidinedione,5-[[3,4-dihydro-2-(phenylmethyl)-2H-1-benzopyran-6-yl]methyl]-, sodium salt. Grade: >98%. CAS No. 109229-57-4. Molecular formula: C20H18NNaO3S. Mole weight: 375.42. | |
| Enibarcimab | Enibarcimab is a humanized monoclonal antibody that has been investigated as a medication for the treatment of acute heart failure and COVID-19. Synonyms: HAM 8101; HAM-8101; HAM8101. CAS No. 2305638-98-4. Molecular formula: C29H36N2O. Mole weight: 428.6. | |
| Enilconazole | Imazalil is an antifungal agent that may have carcinogenic potential. Imazalil also inhibits androgen receptors and aromatase through a mixed competitive/noncompetitive mode in vitro. Synonyms: Imazalil; Deccozil; Bromazil; Fungaflor; Clinafarm; Chloramizol; Fungazil; Magnate; 1-(2-(Allyloxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole; 1-[2-(Allyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole. CAS No. 35554-44-0. Molecular formula: C14H14Cl2N2O. Mole weight: 297.18. | |
| Eniluracil | Eniluracil, also known as GW776 and GW776C85, is an orally active and irreversible inhibitor of dihydropyrimidine dehydrogenase. Eniluracil inhibits dihydropyrimidine dehydrogenase, the rate-limiting enzyme that catabolizes and inactivates 5-fluorouracil (5-FU) in the liver. Co-administration of ethynyluracil permits the oral administration of 5-FU. Uses: Enzyme inhibitors. Synonyms: 5-ethynyluracil; 5-ethynylpyrimidine-2,4(1H,3H)-dione; 5-Ethynyl-2-hydroxypyrimidin-4(1H)-one; GW776; GW-776; GW 776. CAS No. 59989-18-3. Molecular formula: C6H4N2O2. Mole weight: 136.11. | |
| Eniporide | Eniporide is a potent and selective inhibitor of human Na+/H+ exchanger isoform 1 (NHE-1) (IC50 = 4.5 nM). Synonyms: N-(diaminomethylidene)-2-methyl-5-methylsulfonyl-4-pyrrol-1-ylbenzamide. Grade: ≥95%. CAS No. 176644-21-6. Molecular formula: C14H16N4O3S. Mole weight: 320.4. | |
| Enlimomab | Enlimomab is a mouse monoclonal antibody against ICAM-1 and has been observed to inhibit neutrophil adhesion to brain endothelium in vitro. Enlimomab is proved to be beneficial in reducing disease activity in a subset of patients with rheumatoid arthritis. Synonyms: BI-RR 0001; BI RR 0001. Grade: 95%. CAS No. 142864-19-5. | |
| ENMD-1068 | ENMD-1068 is a PAR-2 antagonist. ENMD-1068 inhibits the development of endometriosis in a mouse model. Synonyms: ENMD1068; ENMD 1068; Piperazine, 1-(6-amino-1-oxohexyl)-4-(3-methyl-1-oxobutyl)-. CAS No. 789488-77-3. Molecular formula: C15H29N3O2. Mole weight: 283.41. | |
| ENMD-1068 hydrochloride | ENMD-1068 hydrochloride is a selective antagonist of protease-activated receptor 2 (PAR2) with antiangiogenic and anti-inflammatory activities. It reduces epatic stellate cells (HSCs) activation and collagen expression through the inhibiton of TGF-β1/Smad signal transduction. Grade: 98%. Molecular formula: C15H30ClN3O2. Mole weight: 319.87. | |
| ENMD-1198 | ENMD-1198 is an analog of 2-methoxyestradiol (2ME2) with antiproliferative and antiangiogenic activity. ENMD-1198 is a novel tubulin-binding agent that reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells. Synonyms: IRC-110160; 2-methoxyoestra-1,3,5(10),16-tetraene-3-carboxamide. Grade: 98%. CAS No. 864668-87-1. Molecular formula: C20H25NO2. Mole weight: 311.42. | |
| ENMD-2076 | ENMD-2076 is an orally-active, Aurora A/angiogenic kinase inhibitor with a unique kinase selectivity profile and multiple mechanisms of action. ENMD-2076 has been shown to inhibit a distinct profile of angiogenic tyrosine kinase targets in addition to the Aurora A kinase. Aurora kinases are key regulators of mitosis (cell division), and are often over-expressed in human cancers. ENMD-2076 also targets the VEGFR, Flt-3 and FGFR3 kinases which have been shown to play important roles in the pathology of several cancers. ENMD-2076 has shown promising activity in Phase 1 clinical trials in solid tumor cancers, leukemia, and multiple myeloma. ENMD-2076 is currently in a Phase 2 trial for ovarian cancer, and preclinical and clinical activities are ongoing in assessing the compound's applicability for other forms of cancer. Synonyms: ENMD-2076; ENMD 2076; ENMD2076. CAS No. 934353-76-1. Molecular formula: C21H25N7. Mole weight: 375.47. | |
| ENMD-2076 L-(+)-Tartaric acid | ENMD-2076 L-(+)-Tartaric acid is the tartaric acid of ENMD-2076, selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold more selective for Aurora A than Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2. Synonyms: ENMD-2076 L-(+)-Tartaric acid; ENMD 2076 L-(+)-Tartaric acid; ENMD2076 L-(+)-Tartaric acid. Grade: >98%. CAS No. 1291074-87-7. Molecular formula: C25H31N7O6. Mole weight: 525.56. | |
| Enokizumab | Enokizumab is a monoclonal antibody targeting interleukin-9. Synonyms: MEDI-528; MEDI 528; MEDI528. CAS No. 909875-08-7. | |
| Enoxacin hydrate | Enoxacin hydrate is a synthetic antibiotic belonging to quinolone carboxylic acid compound. It is bactericidal and has a postantibiotischen effect. It is a broad-spectrum antibacterial agent and inhibited 90% Escherichia coli, Klebsiella sp., Aeromonas sp., Enterobacter spp., Serratia spp., Proteus mirabilis, and Morganella morganii at less than or equal to 0.8 micrograms/ml. Uses: Enoxacin hydrate is bactericidal and has a postantibiotischen effect. it is a broad-spectrum antibacterial agent. Synonyms: Enoxacin sesquihydrate; AT-2266 hydrate; CI-919 hydrate; AT 2266 hydrate; CI 919 hydrate; AT2266 hydrate; CI919 hydrate; 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic Acid hydrate. Grade: >98%. CAS No. 84294-96-2. Molecular formula: C30H40F2N8O9. Mole weight: 694.694. | |
| Enoximone | Enoximone is a selective phosphodiesterase III (PDE3) inhibitor. It can be used for the treatment of heart failure. Uses: Heart failure. Synonyms: Enoximone; Perfan; Fenoximone; MDL-17043; Enoximonum [Latin]; MDL 19438; MDL-17,043; MDL-17043; MDL-19,438; MDL17,043; MDL17043; MDL19,438; Myogen Brand of Enoximone; Perfan; 1,3-Dihydro-4-methyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-one; Fenoximone; MDL 17043; Perfan; Perfane; RMI 17043. Grade: 98%. CAS No. 77671-31-9. Molecular formula: C12H12N2O2S. Mole weight: 248.3. | |
| Enpatoran | Enpatoran is a potent and orally active dual inhibitor of TLR7/8 with IC50s of 11.1 and 24.1 nM in HEK293 cells, respectively. It blocks molecule synthetic ligands and natural endogenous RNA ligands. It has good pharmacokinetic properties in vivo and can be used to study innate and adaptive autoimmune blocks. Synonyms: 8-Quinolinecarbonitrile, 5-[(3R,5S)-3-amino-5-(trifluoromethyl)-1-piperidinyl]-; 5-[(3R,5S)-3-Amino-5-(trifluoromethyl)-1-piperidinyl]-8-quinolinecarbonitrile; 5-((3R,5S)-3-Amino-5-trifluoromethylpiperidin-1-yl)quinoline-8-carbonitrile; M 5049; M5049; M-5049. Grade: ≥95%. CAS No. 2101938-42-3. Molecular formula: C16H15F3N4. Mole weight: 320.31. | |
| Enpatoran hydrochloride | Enpatoran hydrochloride is a potent and orally active dual inhibitor of TLR7/8 with IC50s of 11.1 and 24.1 nM in HEK293 cells, respectively. Enpatoran hydrochloride has no effect on TLR3, TLR4 and TLR9. It blocks molecule synthetic ligands and natural endogenous RNA ligands. It has good pharmacokinetic properties in vivo and can be used to study innate and adaptive autoimmune block. Synonyms: M5049 hydrochloride; 5-[(3R,5S)-3-Amino-5-(trifluoromethyl)-1-piperidinyl]-8-quinolinecarbonitrile hydrochloride (1:1); 8-Quinolinecarbonitrile, 5-[(3R,5S)-3-amino-5-(trifluoromethyl)-1-piperidinyl]-, hydrochloride (1:1). Grade: ≥98%. CAS No. 2101945-93-9. Molecular formula: C16H16ClF3N4. Mole weight: 356.77. | |
| Enpp-1-IN-1 | Enpp-1-IN-1 is an inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). Synonyms: UUN28589; MV 658. CAS No. 2289728-58-9. Molecular formula: C17H17N3O3S. Mole weight: 343.40. | |
| Enprofylline | Enprofylline, a xanthine derivative, is a a competitive nonselective phosphodiesterase inhibitor with relatively little activity as a nonselective adenosine receptor antagonist used in the treatment of asthma, which acts as a bronchodilator. Uses: Nonselective adenosine receptor antagonist. Synonyms: 3-Propylxanthine; 3-propyl-7H-purine-2,6-dione. Grade: ≥98%. CAS No. 41078-02-8. Molecular formula: C8H10N4O2. Mole weight: 194.19. | |
| Enprostil | Enprostil is a synthetic analog of prostaglandin E2, which is effective in the treatment of patients with duodenal or gastric ulcers. Uses: Anti-ulcer agents. Synonyms: gardrin; Enprotil. Grade: 95%. CAS No. 73121-56-9. Molecular formula: C23H28O6. Mole weight: 400.468. | |
| Enrasentan | Enrasentan, an indene derivative, has been found to be an endothelin receptor antagonist that was once studied in reperfusion injury and heart failure therapy. Synonyms: Enrasentan; SB-217242; UNII-QG16H8A6ZH; SB 217242; SB217242; CHEMBL431651; (1S,2R,3S)-1-(1,3-benzodioxol-5-yl)-3-[2-(2-hydroxyethoxy)-4-methoxyphenyl]-5-propoxy-2,3-dihydro-1H-indene-2-carboxylic acid. Grade: 98%. CAS No. 167256-08-8. Molecular formula: C29H30O8. Mole weight: 506.55. | |
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