BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| ENS-163 phosphate | It is a selective muscarinic M1 receptor agonist. Synonyms: ENS 213-163; Sandoz ENS 163 phosphate; Thiopilocarpine phosphate; Phosphoric acid-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]thiolan-2-one (1/1). CAS No. 117707-51-4. Molecular formula: C11H19N2O5PS. Mole weight: 322.32. |  |
| Ensartinib dihydrochloride | Ensartinib is a potent new-generation ALK inhibitor with high activity against a broad range of known crizotinib-resistant ALK mutations and CNS metastases. Ensartinib has the potential for the treatment of crizotinib-resistant, ALK-positive non-small-cell lung cancer. Synonyms: X-396 dihydrochloride; X-396 2HCl. CAS No. 2137030-98-7. Molecular formula: C26H29Cl4FN6O3. Mole weight: 634.36. | |
| Ensemble Compound 159 | Ensemble Compound 159 is a peptide inhibitor of IL-17A that binds to IL-17A and/or inhibits formation of the IL-17A-IL-17RA complex via an ELISA assay, an HT29-GROα cell based functional assay, a rheumatoid arthritis synovial fibroblast (RASF) assay, and surface plasmon resonance (SPR, Kd < 100 nM) based biophysical binding assessment. Grade: 97%. CAS No. 1449208-36-9. Molecular formula: C42H51ClN6O6. Mole weight: 771.34. | |
| Ensitrelvir fumarate | Ensitrelvir fumarate is the first orally active, non-covalent and non-peptidic inhibitor of SARS-CoV-2 3CL protease with an IC50 of 13 nM. Synonyms: S-217622 fumarate; Xocova fumarate; (6E)-6-[(6-chloro-2-methyl-2H-indazol-5-yl)imino]dihydro-3-[(1-methyl-1H-1,2,4-triazol-3-yl)methyl]-1-[(2,4,5-trifluorophenyl)methyl]-1,3,5-triazine-2,4(1H,3H)-dione (2E)-2-butenedioate. Grade: ≥95%. CAS No. 2757470-18-9. Molecular formula: C26H21ClF3N9O6. Mole weight: 647.95. | |
| Ensituximab | Ensituximab is a chimeric monoclonal IgG1 antibody that targets a glycosylated variant of MUC5AC with specificity to colorectal and pancreatic cancer. Ensituximab was well tolerated and demonstrated modest antitumor activity in patients with heavily pretreated refractory colorectal cancer. Synonyms: NPC-1C; NPC 1C; NPC1C; NEO-102; NEO 102; NEO102. Grade: 95%. CAS No. 1092658-06-4. Molecular formula: C6342H9800N1678O1985S46. Mole weight: 142.8 kDa. | |
| ENT 25641 | This active molecular is a bio-active chemical and detailed information has not been published yet. Synonyms: 4-(Aminosulfonyl)phenyl dimethyl phosphate,AC 28,865 AI3-25641; American cyanamid CL-28865; Benzenesulfonamide, p-hydroxy-, dimethyl phosphate; BRN 2148113; CL 28865; BRN2148113; CL28865; BRN-2148113; CL-28865. Grade: 98%. CAS No. 115-92-4. Molecular formula: C8H12NO6PS. Mole weight: 281.22. | |
| ENT 25642 | ENT 25642, a sulfamide derivative, could have potential activities in sorts of biological studies. Synonyms: ENT 25642; ENT25642; ENT-25642; BRN 2168785; CL-35217; AC 35,217; ENT 25,642. Grade: 98%. CAS No. 1713-54-8. Molecular formula: C11H18NO5PS2. Mole weight: 339.37. | |
| ent-9-Desmethyl-alpha-Dihydro-Tetrabenazine | Ent-9-Desmethyl-alpha-Dihydro-Tetrabenazine is one of Tetrabenazine derivatives. Tetrabenazine is a VMAT-inhibitor used for treatment of hyperkinetic movement disorder. It is a monoamine-depleting and a dopamine-receptor-blocking drug and is an effective and safe drug for the treatment of a variety of hyperkinetic movement disorders. Synonyms: (-)-9-O-Desmethyl-alpha-dihydrotetrabenazine; (2S,3R,11bS)-10-Methoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-2,9-diol; (-)-9-deMe-DTBZ; 3-isobutyl-10-methoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline-2,9-diol. Grade: ≥95%. CAS No. 1065193-41-0. Molecular formula: C18H27NO3. Mole weight: 305.41. | |
| ent-Abacavir | ent-Abacavir (Abacavir EP Impurity A) is an enantiomer of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. Uses: Anti-hiv agents. Synonyms: (1R,4S)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; (1R-cis)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; (1R,4S)-Abacavir; Abacavir EP Impurity A. Grade: 97%. CAS No. 136470-79-6. Molecular formula: C14H18N6O. Mole weight: 286.33. | |
| Entacapone | Entacapone is a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT) (IC50 = 151 nM), commonly used in combination with other medications for the treatment of Parkinson's disease. Synonyms: 2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2E)-; Comtan; HSDB 8251; HSDB-8251; HSDB8251; OR-611; OR 611; OR611; (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide; 2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (E)-; (E)-Entacapone; Comtess; Entacom; Parkicapone. Grade: >98%. CAS No. 130929-57-6. Molecular formula: C14H15N3O5. Mole weight: 305.29. | |
| Entacapone 3-b-D-glucuronide | Entacapone 3-b-D-glucuronide is a metabolite of Entacapone, which is a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT) used in combination with other medications for the treatment of Parkinson's disease. Synonyms: β-D-Glucopyranosiduronic acid, 5-[(1E)-2-cyano-3-(diethylamino)-3-oxo-1-propen-1-yl]-2-hydroxy-3-nitrophenyl; 5-[(1E)-2-Cyano-3-(diethylamino)-3-oxo-1-propen-1-yl]-2-hydroxy-3-nitrophenyl β-D-glucopyranosiduronic acid; β-D-Glucopyranosiduronic acid, 5-[(1E)-2-cyano-3-(diethylamino)-3-oxo-1-propenyl]-2-hydroxy-3-nitrophenyl; β-D-Glucopyranosiduronic acid, 5-[2-cyano-3-(diethylamino)-3-oxo-1-propenyl]-2-hydroxy-3-nitrophenyl, (E)-; Entacapone 3-β-D-glucuronide. Grade: ≥95%. CAS No. 158069-75-1. Molecular formula: C20H23N3O11. Mole weight: 481.41. | |
| Entacapone EP Impurity A | Isomer of Entacapone. Entacapone is a medication commonly used in combination with other medications for the treatment of Parkinson's disease. Synonyms: cis-Entacapone; (2Z)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide; (Z)-Entacapone. Grade: > 95%. CAS No. 145195-63-7. Molecular formula: C14H15N3O5. Mole weight: 305.29. | |
| Entacapone EP Impurity B | An impurity of Entacapone. Entacapone is a medication commonly used in combination with other medications for the treatment of Parkinson's disease. Synonyms: Ethyl (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)prop-2-enoate. Grade: > 95%. Molecular formula: C12H10N2O6. Mole weight: 278.22. | |
| Entacapone EP Impurity C | An impurity of Entacapone. Entacapone is a medication commonly used in combination with other medications for the treatment of Parkinson's disease. Synonyms: 3,4-Dihydroxy-5-nitrobenzaldehyde. Grade: > 95%. CAS No. 116313-85-0. Molecular formula: C7H5NO5. Mole weight: 183.12. | |
| Entacapone EP Impurity D | An impurity of Entacapone. Entacapone is a medication commonly used in combination with other medications for the treatment of Parkinson's disease. Synonyms: (2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide. Grade: > 95%. CAS No. 857629-79-9. Molecular formula: C16H19N3O5. Mole weight: 333.35. | |
| Entacapone EP Impurity E | An impurity of Entacapone. Entacapone is a medication commonly used in combination with other medications for the treatment of Parkinson's disease. Synonyms: 3,5-Dinitrobenzene-1,2-diol ; 1,2-Dihydroxy-3,5-dinitrobenzene. Grade: > 95%. CAS No. 7659-29-2. Molecular formula: C6H4N2O6. Mole weight: 200.11. | |
| Entacapone EP Impurity F | An impurity of Entacapone. Entacapone is a medication commonly used in combination with other medications for the treatment of Parkinson's disease. Synonyms: Entacapone acid; (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)prop-2-enoic acid; 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-, (2E)-; (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-2-propenoic acid; 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-, (E)-; AG 1290; Tyrphostin AG 1290. Grade: ≥95%. CAS No. 160391-70-8. Molecular formula: C10H6N2O6. Mole weight: 250.17. | |
| Entacapone EP Impurity G | An impurity of Entacapone. Entacapone is a medication commonly used in combination with other medications for the treatment of Parkinson's disease. Synonyms: (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N-methyl-prop-2-enamide. Grade: > 95%. CAS No. 1364322-41-7. Molecular formula: C11H9N3O5. Mole weight: 263.21. | |
| Entacapone EP Impurity H | An impurity of Entacapone. Entacapone is a medication commonly used in combination with other medications for the treatment of Parkinson's disease. Synonyms: (2E)-3-(3,4-Dihydroxy-5-nitrophenyl)-2-(piperidin-1-ylcarbonyl)prop-2-ennitrile. Grade: > 95%. CAS No. 1150310-15-8. Molecular formula: C15H15N3O5. Mole weight: 317.30. | |
| Entacapone EP Impurity I | An impurity of Entacapone. Entacapone is a medication commonly used in combination with other medications for the treatment of Parkinson's disease. Synonyms: Propyl (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)prop-2-enoate. Grade: > 95%. CAS No. 1364322-42-8. Molecular formula: C13H12N2O6. Mole weight: 292.25. | |
| Entacapone sodium salt | Entacapone is a specific, potent catechol-O-methyl transferase (COMT) inhibitor with IC50 of 151 nM for PD treatment. Synonyms: Entacapone sodium salt; 1047659-02-8; Entacapone (sodium salt); Entacapone Sodiumsodium; 4-[(E)-2-cyano-3-(diethylamino)-3-oxoprop-1-enyl]-2-hydroxy-6-nitrophenolate. Grade: >98%. CAS No. 1047659-02-8. Molecular formula: C14H14N3NaO5. Mole weight: 327.27. | |
| entadecafluorooctanoic Acid-[13C] | entadecafluorooctanoic Acid-[13C]. Synonyms: Pentadecafluoro(1-13C)octanoic acid; Perfluoro-n-octanoic acid-1-13C; Octanoic-1-13C acid, 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluoro-. CAS No. 864071-09-0. Molecular formula: C87[13C]HF15O2. Mole weight: 415.08. | |
| Ent-α-C Dapagliflozin | Ent-α-C Dapagliflozin is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: (2S,3S,4S,5R,6S)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol. Grade: >95%. Molecular formula: C21H25ClO6. Mole weight: 408.87. | |
| ent-Aprepitant | A metabolite of Aprepitant. Aprepitant is a selective neurokinin-1 (NK-1) receptor antagonist used to prevent chemotherapy-induced nausea and vomiting (CINV) and to prevent postoperative nausea and vomiting. Synonyms: 3-[[(2S,3R)-2-[(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholino]methyl]-1H-1,2,4-triazol-5(4H)-one; (1S,2S,3R)-Aprepitant; USP Aprepitant Related Compound B; Aprepitant S,R,S-Enantiomer; Aprepitant USP Related Compound B; Aprepitant Related Compound B; 5-(((2S,3R)-2-((1S)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4-morpholinyl)methyl)-1,2-dihydro-3H-1,2,4-triazol-3-one; 3H-1,2,4-Triazol-3-one, 5-[[2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-, [2S-[2α(R*),3α]]-; Aprepitant USP RC B; Aprepitant S,R,S-isomer. Grade: >95%. CAS No. 172822-29-6. Molecular formula: C23H21F7N4O3. Mole weight: 534.44. | |
| Entasobulin | Entasobulin is a tubulin polymerization inhibitor with potential anticancer activity. Entasobulin is a indolizine-glyoxylamide based small molecule that demonstrate substantial in vitro anti-proliferative activities against cancer cell lines, including multidrug resistance (MDR) phenotypes. The in vitro cytotoxic effects have been demonstrated across a wide array of tumor types of various origins (e.g., breast, colon, uterine). Synonyms: Entasobulin; UNII-TB77GU6BFO; UNII TB77GU6BFO. CAS No. 501921-61-5. Molecular formula: C26H18ClN3O2. Mole weight: 439.89. | |
| ent-Benazepril | ent-Benazepril is the enantiomer of Benazopril and a less potent antihypertensive. Synonyms: 1H-1-Benzazepine-1-acetic acid, 3-[[(1R)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, (3R)-; (3R)-3-[[(1R)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid; Benazepril, (R,R)-; 2-((R)-3-(((R)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid; (R,R)-Benazepril; CGP-42456A; 1H-1-Benzazepine-1-acetic acid, 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-, (R-(R*,R*))-; Benazepril EP Impurity A; Benazepril Related Compound A. Grade: ≥95%. CAS No. 131064-75-0. Molecular formula: C24H28N2O5. Mole weight: 424.50. | |
| ent-Cinacalcet Hydrochloride | ent-Cinacalcet Hydrochloride is the (S) enantiomer of Cinacalcet. It is used in clinical trial in secondary hyperparathyroidism. Synonyms: (αS)-α-Methyl-N-[3-[3-(trifluoromethyl)phenyl)propyl]-1-napthalenemethanamine Hydrochloride; (S)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride; (S)-Cinacalcet hydrochloride. Grade: > 95%. CAS No. 694495-47-1. Molecular formula: C22H23ClF3N. Mole weight: 393.87. | |
| ent-Defluoro Aprepitant | ent-Defluoro Aprepitant is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C23H22F6N4O3. Mole weight: 516.44. | |
| ent-Defluoro Fosaprepitant Dimeglumine | ent-Defluoro Fosaprepitant Dimeglumine is an eminent biomedical compound, used in studying chemotherapy-induced nausea and vomiting. Its profound pharmacological mechanism as a neurokinin-1 receptor antagonist profoundly impedes the detrimental interaction between substance P and its specific receptor. Grade: > 95%. Molecular formula: C37H57F6N6O16P. Mole weight: 986.87. | |
| Entecavir | An oral antiviral drug used in the treatment of hepatitis B infection. A guanine analogue that inhhibits all three steps in the viral replication process. Synonyms: Baraclude; BMS 200475; BMS-200475; BMS200475; SQ 34676; SQ34676; SQ-34676. Grade: 0.98. CAS No. 142217-69-4. Molecular formula: C12H15N5O3. Mole weight: 277.284. | |
| Entecavir-[13C2,15N] 3''-O-β-D-Glucuronide | A labelled metabolite of Entecavir. Synonyms: 2-Amino-9-[4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-3H-purin-6-one-13C2,15N 3''-O-β-D-Glucuronide; Entecavir-13C2,15N 3''-O-β-D-Glucuronide. Molecular formula: C16[13C]2H23N4[15N]O9. Mole weight: 456.39. | |
| Entecavir 3-O-b-D-glucuronide | Entecavir 3-O-b-D-glucuronide is an essential compound utilized within the biomedical realm, boasting its efficaciousness in studying the persisting malady of chronic hepatitis B virus (HBV) infection. Functioning as an exemplary antiviral entity, it effectively impedes the retrograde transcription of HBV DNA, thus curbing viral replication. Molecular formula: C18H23N5O9. Mole weight: 453.40. | |
| Entecavir 3''-O-β-D-Glucuronide | A metabolite of Entecavir. Entecavir is a reverse transcriptase inhibitor. It prevents the hepatitis B virus from multiplying and reduces the amount of virus in the body. Synonyms: 2-Amino-9-[4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-3H-purin-6-one 3''-O-β-D-Glucuronide; Entecavir Glucuronide; Entecavir 3''-O-b-D-glucuronide. Grade: ≥95%. Molecular formula: C18H23N5O9. Mole weight: 453.41. | |
| Entecavir-d2 | An isotope labelled Entecavir. Entecavir is a reverse transcriptase inhibitor. It prevents the hepatitis B virus from multiplying and reduces the amount of virus in the body. Synonyms: BMS200475-d2; SQ34676-d2. Grade: > 95%. Molecular formula: C12H13D2N5O3. Mole weight: 279.29. | |
| Entecavir Impurity 2 | An impurity of Entecavir. Entecavir is a reverse transcriptase inhibitor. It prevents the hepatitis B virus from multiplying and reduces the amount of virus in the body. Synonyms: (2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(benzyloxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanone. Grade: > 95%. CAS No. 142217-79-6. Molecular formula: C52H47N5O5. Mole weight: 821.98. | |
| Entecavir Impurity 3 | An impurity of Entecavir. Entecavir is a reverse transcriptase inhibitor. It prevents the hepatitis B virus from multiplying and reduces the amount of virus in the body. Synonyms: 6-(Benzyloxy)-9-((1S,3R,3S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine. Grade: > 95%. CAS No. 142217-80-9. Molecular formula: C53H49N5O4. Mole weight: 820.01. | |
| Entecavir Impurity 4 | An impurity of Entecavir. Entecavir is a reverse transcriptase inhibitor. It prevents the hepatitis B virus from multiplying and reduces the amount of virus in the body. Synonyms: 6-(benzyloxy)-9-((1R,3R,4S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylenecyclopentyl)-9H-purin-2-amine. Grade: > 95%. Molecular formula: C33H33N5O3. Mole weight: 547.66. | |
| Entecavir Impurity 5 | An impurity of Entecavir. Entecavir is a reverse transcriptase inhibitor. It prevents the hepatitis B virus from multiplying and reduces the amount of virus in the body. Synonyms: methoxy-(p-methoxytriphenyl)methane; 4.α-Dimethoxy-tritan; methoxy-(4-methoxy-phenyl)-diphenyl-methane; Methoxy-(4-methoxy-phenyl)-diphenyl-methan; Methyl-(4-methoxy-trityl)-aether. Grade: > 95%. CAS No. 84868-56-4. Molecular formula: C21H20O2. Mole weight: 304.39. | |
| Entecavir Impurity E | An impurity of Entecavir. Entecavir is a reverse transcriptase inhibitor. It prevents the hepatitis B virus from multiplying and reduces the amount of virus in the body. Synonyms: 2-amino-9-((1R,3R,4S)-3-(hydroxymethyl)-2-methylene-4-((trimethylsilyl)oxy)cyclopentyl)-3H-purin-6(9H)-one. Grade: > 95%. Molecular formula: C14H21N5O4Si. Mole weight: 351.44. | |
| Entecavir Impurity ET-2 | An impurity of Entecavir. Entecavir is a reverse transcriptase inhibitor. It prevents the hepatitis B virus from multiplying and reduces the amount of virus in the body. Synonyms: 2-amino-9-((1R,3R,4R)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl)-3H-purin-6(9H)-one. Grade: > 95%. Molecular formula: C12H15N5O3. Mole weight: 277.29. | |
| Entecavir Phosphoramidite | Entecavir Phosphoramidite is a modified phosphoramidite derived from Entecavir, a nucleoside analog commonly used as an antiviral drug for the treatment of chronic hepatitis B virus (HBV) infections. The phosphoramidite group at the 3' position allows for the incorporation of Entecavir into oligonucleotides during solid-phase synthesis. Entecavir itself is an oral antiviral medication that works by inhibiting the reverse transcriptase enzyme of HBV, thus preventing viral replication. When used as a phosphoramidite in oligonucleotide synthesis, Entecavir provides the ability to create modified oligonucleotides with specific antiviral properties or to facilitate antiviral research and development, including the design of antisense oligonucleotides or RNA-based therapeutics. This phosphoramidite can be used in therapeutic applications targeting HBV or in the development of tools for studying viral replication, antiviral resistance mechanisms, and other aspects of virology. It could also potentially be utilized in the design of oligonucleotides with specialized antiviral or gene-editing functions. Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, (1S,2R,4S)-2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-[1,6-dihydro-2-[(2-methyl-1-oxopropyl)amino]-6-oxo-9H-purin-9-yl]-3-methylenecyclopentyl 2-cyanoethyl ester. Grade: ≥97%. CAS No. 3054794-07-6. Molecular formula: C46H56N7O7P. Mole weight: 849.96. | |
| Entecavir Related Compound A | An impurity of Entecavir. Entecavir is a reverse transcriptase inhibitor. It prevents the hepatitis B virus from multiplying and reduces the amount of virus in the body. Synonyms: Entecavir EP Impurity F; Entecavir USP Related Compound A; 2-Amino-9-[(1S,3R,4S)-4-(dimethylphenylsilyl)-2-methylene-3-[(phenylmethoxy)methyl]cyclopentyl]-1,9-dihydro-6H-purin-6-one. Grade: > 95%. CAS No. 649761-24-0. Molecular formula: C27H31N5O2Si. Mole weight: 485.67. | |
| ent-Emtricitabine 4-Acetamide 5'-O'-Benzoyl | ent-Emtricitabine 4-Acetamide 5'-O'-Benzoyl is a protected intermediate in the ent-Emtricitabine synthesis, a reverse transcriptase inhibitor that is effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. Molecular formula: C17H16FN3O5S. Mole weight: 393.39. | |
| ent-Ezetimibe | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L3) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: R,S,R-Ezetimibe; (3S,4R)-1-(4-Fluorophenyl)-3-[(R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one; (3S,4R)-1-(4-Fluorophenyl)-3-[(3R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone; Ezetimibe (3S,4R,3'R)-Isomer; Ezetimibe (RSR)-Isomer; ent-SCH 58235; (3S,4R,3'R)-Ezetimibe. Grade: >95%. CAS No. 1376614-99-1. Molecular formula: C24H21F2NO3. Mole weight: 409.44. | |
| Ent-Galantamine | Ent-Galantamine is the (+) enantiomer of Galanthamine and acts as a selective inhibitor of acetylcholinesterase(AChE). Synonyms: Galantamine Impurity F; (4aR,6S,8aR)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofurol[3a,3,2,-ef][2]benzazepin-6-ol; (+)-Galanthamine. Grade: > 95%. CAS No. 60384-53-4. Molecular formula: C17H21NO3. Mole weight: 287.36. | |
| ent-Heronamide C | ent-Heronamide C shows antifungal activity and is designed as a probe to analyze the mode of action of heronamide C. Synonyms: (3E,5E,7E,9R,10S,11Z,13E,15E,20R)-9,10-dihydroxy-7,15-dimethyl-20-((2E,4E)-octa-2,4-dien-1-yl)azacycloicosa-3,5,7,11,13,15-hexaen-2-one. Molecular formula: C29H41NO3. Mole weight: 451.64. | |
| ent-Idoxuridine | The enantiomer of Idoxuridine. Antitumor nucleoside enantiomer thymidine kinase used as potential antiviral agents. Synonyms: 1-(2-Deoxy-β-L-erythro-pentofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione; 2'-Deoxy-L-5-iodouridine; 5-Iodo-2'-deoxy-L-uridine. CAS No. 162239-35-2. Molecular formula: C9H11IN2O5. Mole weight: 354.1. | |
| Entinostat | Entinostat is a histone deacetylase (HDAC) inhibitor displaying antiproliferative and antineoplastic effects. Entinostat induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), which slows cell growth, differentiation, and tumor development in vivo. Entinostat is potentially used as an antitumor drug in combination with other drugs like adriamycin, PARP inhibitors and Hsp90 inhibitors. Uses: Histone deacetylase inhibitors. Synonyms: MS275; MS-275; MS 2275; SNDX275; SNDX-275; SNDX 275; Entinostat; pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate. Grade: > 98%. CAS No. 209783-80-2. Molecular formula: C21H20N4O3. Mole weight: 376.416. | |
| ent-Kaurenol | Ent-Kaurenol is a derivative of ent-Kaurane. Ent-Kaurane is an anti-inflammatory found in plants that inhibits various human neutrophil functions. Synonyms: Kaur-16-en-18-ol; Kaurenol; ent-Kaur-16-en-19-ol; (4α)-Kaur-16-en-18-ol; (-)-Kaur-16-en-18-ol; (-)-Kauren-19-ol. CAS No. 2300-11-0. Molecular formula: C20H32O. Mole weight: 288.47. | |
| ent-Lamivudine acid (1S,2R,5S)-5-methyl-2-isopropylcyclohexyl ester | ent-Lamivudine acid (1S,2R,5S)-5-methyl-2-isopropylcyclohexyl ester is an intermediate in the preparation of Lamivudine, a potent nucleoside reverse transcriptase inhibitor and antiviral agent. Lamivudine has also been used for treatment of chronic hepatitis B. Synonyms: 1,3-Oxathiolane-2-carboxylic acid, 5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-, (1S,2R,5S)-5-methyl-2-(1-methylethyl)cyclohexyl ester, (2S,5R)-; (2S,5R)-5-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic Acid (1S,2R,5S)-5-Methyl-2-(1-methylethyl)cyclohexyl Ester; [1S-[1α(2R*,5S*),2β,5α]]-5-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic Acid 5-Methyl-2-(1-methylethyl)cyclohexyl Ester; ent-Lamivudine Acid (1S,2R,5S)-(+)-Menthol Ester; ent-Lamivudine Acid D-Menthol Ester; (1S,2R,5S)-5-Methyl-2-(1-methylethyl)cyclohexyl (2S,5R)-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate; 1,3-Oxathiolane-2-carboxylic acid, 5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-, 5-methyl-2-(1-methylethyl)cyclohexyl ester, [1S-[1α(2R*,5S*),2β,5α]]-. Grade: ≥95%. CAS No. 147126-74-7. Molecular formula: C18H27N3O4S. Mole weight: 381.50. | |
| ent-Lamivudine Triphosphate Triethylammonium Salt | ent-Lamivudine Triphosphate Triethylammonium Salt is a metabolite of Lamivudine, a potent nucleoside reverse transcriptase inhibitor and antiviral agent. Lamivudine has also been used for treatment of chronic hepatitis B. Synonyms: ((2R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl Tetrahydrogen Triphosphate Triethylammonium Salt. Grade: 96%. Molecular formula: C8H14N3O12P3S.xC6H15N. Mole weight: 469.20 (free acid). | |
| Ent-Oseltamivir | Ent-Oseltamivir is an impurity of the antiviral drug oseltamivir, which can be used in COVID19-related research. Synonyms: (3S,4S,5R)-ethyl 4-acetamido; (3S,4S,5R)-ethyl 4-acetamido-5-amino. CAS No. 1035895-88-5. Molecular formula: C16H28N2O4. Mole weight: 312.40. | |
| ent-Oseltamivir Phosphate | ent-Oseltamivir Phosphate is the enatiomer of Oseltamivir Phosphate, which is a prodrug of the influenza neuraminidase inhibitor Oseltamivir. Synonyms: (3S,4S,5R)-4-(Acetylamino)-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester phosphate; 1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-5-amino-3-(1-ethylpropoxy)-, ethyl ester, (3S,4S,5R)-, phosphate (1:1); (3S,4S,5R)-Ethyl 4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate phosphate. Grade: ≥95%. CAS No. 1035895-89-6. Molecular formula: C16H31N2O8P. Mole weight: 410.40. | |
| Entospletinib | Entospletinib (GS-9973) is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM. Phase 2. Synonyms: GS9973; GS 9973; GS-9973. Grade: >98%. CAS No. 1229208-44-9. Molecular formula: C23H21N7O. Mole weight: 411.46. | |
| ent-Paroxetine Hydrochloride | An impurity of Paroxetine which is an oral antidepressant formally approved in the United States. Synonyms: (3R-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine Hydrochloride; (3R,4S)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine Hydrochloride; USP Paroxetine Related Compound C; Paroxetine EP Impurity D. Grade: > 95%. CAS No. 130855-30-0. Molecular formula: C19H20FNO3.HCl. Mole weight: 365.83. | |
| ent-Paroxol | Paroxol can be used to synthesis Paroxetine. Synonyms: (3R,4S)-4-(4-Fluorophenyl)-1-methyl-3-piperidinemethanol; (+)-Paroxol; (+)-trans-4-(4'-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine; (3R,4S)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine. Grade: > 95%. CAS No. 389573-45-9. Molecular formula: C13H18FNO. Mole weight: 223.29. | |
| Entrectinib | Entrectinib (RXDX-101) is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. Phase 2. Uses: Protein kinase inhibitors. Synonyms: RXDX101; RXDX 101; RXDX-101; NMS E628; NMS-E628; Entrectinib; N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(oxan-4-ylamino)benzamide. Grade: ≥98%. CAS No. 1108743-60-7. Molecular formula: C31H34F2N6O2. Mole weight: 560.64. | |
| ent-Rosuvastatin tert-Butyl Ester | An impurity of Rosuvastatin.Rosuvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. Synonyms: (3S,5R,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic Acid tert-Butyl Ester. Grade: > 95%. CAS No. 615263-60-0. Molecular formula: C26H36FN3O6S. Mole weight: 537.66. | |
| ent-Rotigotine | ent-Rotigotine is a non-ergot dopamine agonist drug used to treat Parkinson's disease. Synonyms: 1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-, (6R)-; (6R)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol; 1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-, (R)-; (+)-N 0437; N 0924; (R)-6-(propyl(2-(thiophen-2-yl)ethyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol; (+)-Rotigotine; (R)-Rotigotine. Grade: ≥95%. CAS No. 112835-48-0. Molecular formula: C19H25NOS. Mole weight: 315.47. | |
| ent-Sofosbuvir Desphosphate | ent-Sofosbuvir Desphosphate is a possible metabolite of prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Molecular formula: C10H13FN2O5. Mole weight: 260.22. | |
| ent-Ticagrelor | An impurity of Ticagrelor which is a reversible P2Y12 receptor antagonist and is unique in its greater and more rapid and consistent, yet reversible, inhibition of the ADP receptor. Synonyms: (1R,2R,3S,5R)-3-(7-(((1S,2R)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol; Ticagrelor impurity J. CAS No. 2096989-55-6. Molecular formula: C23H28F2N6O4S. Mole weight: 522.57. | |
| Enuvaptan | Enuvaptan is an antagonist of vasopressin receptor with potential to study renal and cardiovascular diseases. Synonyms: BAY-2327949; 1H-1,2,4-Triazole-5-carboxamide, 3-[[3-(4-chlorophenyl)-4,5-dihydro-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-1H-1,2,4-triazol-1-yl]methyl]-1-[3-(trifluoromethyl)-2-pyridinyl]-; 3-((3-(4-Chlorophenyl)-5-oxo-4-((2S)-3,3,3-trifluoro-2-hydroxypropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl)methyl)-1-(3-(trifluoromethyl)pyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide. Grade: ≥90%. CAS No. 2145062-48-0. Molecular formula: C21H15ClF6N8O3. Mole weight: 576.84. | |
| Envafolimab | Envafolimab is a recombinant protein of a humanized single-domain anti-PD-L1 antibody. Envafolimab has obtained the U.S. FDA's orphan drug designation for advanced biliary tract cancer. Synonyms: ASC 22; ASC22; ASC-22; KN 035; KN035; KN-035. CAS No. 2102192-68-5. | |
| Envelope glycoprotein GP120 | Envelope glycoprotein GP120 is a glycoprotein exposed on the surface of the HIV envelope. Envelope glycoprotein GP120 is essential for virus entry into cells as it plays a vital role in attachment to specific cell surface receptors. Synonyms: GP 120. Mole weight: 120 kDa. | |
| Enviroxime | Enviroxime is a benzimidazole derivative that inhibits the replication of rhinoviruses and poliovirus by targeting protein 3A. Enviroxime exhibits antiviral effects against EV71 with EC50 of 0.15 μM. Uses: Coxsackievirus infections; picornavirus infections. Synonyms: ENVIROXIME; Viroxime; 72301-79-2; Viroxime component B; 63198-97-0; (NE)-N-[(2-amino-3-propan-2-ylsulfonylbenzimidazol-5-yl)-phenylmethylidene]hydroxylamine; NSC-346230; 72301-78-1; LY-122772; (E)-2-Amino-6-benzoyl-1-(isopropylsulfonyl)benzimidazole oxime; LY 122771-72; NSC346230; LY 122772; 2-Amino-1-(isopropylsulfonyl)-6-benzimidazole phenyl ketone oxime; 1H-Benzimidazol-2-amine, 6-((hydroxyimin. Grade: 98%. CAS No. 72301-79-2. Molecular formula: C3H8OS2. Mole weight: 124.23. | |
| Envonalkib | Envonalkib is a potent and orally active inhibitor of ALK, with IC50s of 1.96 nM, 35.1 nM, and 61.3 nM for WT and mutated L1196M and G1269S-ALK. Envonalkib can be used in the research of non-small cell lung cancer. Synonyms: 5-((1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-4'-methoxy-6'-((2S)-2-methyl-1-piperazinyl)(3,3'-bipyridin)-6-amine; US9708295, 27. CAS No. 1621519-26-3. Molecular formula: C24H26Cl2FN5O2. Mole weight: 506.40. | |
| Enzalutamide | Enzalutamide is an androgen-receptor (AR) antagonist with IC50 of 36 nM. It inhibits the activity of prostate cancer cell Ars, which over expressed in prostate cancer. Uses: Potential antineoplastic agent. Synonyms: MDV3100; MDV 3100; MDV-3100; 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide; Benzamide, 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methyl-; 4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methylbenzamide; S-Enzalutamide; Xtandi. Grade: >98%. CAS No. 915087-33-1. Molecular formula: C21H16F4N4O2S. Mole weight: 464.44. | |
| Enzalutamide Carboxylic Acid | Enzalutamide Carboxylic Acid is a metabolite of Enzalutamide. Enzalutamide Carboxylic Acid is used as hormone therapies to prevent androgen-fuled growth of castrate-resistant prostate cancer. Synonyms: 4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-benzoic Acid. CAS No. 1242137-15-0. Molecular formula: C20H13F4N3O3S. Mole weight: 451.4. | |
| Enzalutamide Carboxylic acid-D6 | An isotope labelled of Enzalutamide Carboxylic Acid. Enzalutamide Carboxylic Acid can be used as hormone therapies to prevent androgen-fuled growth of castrate-resistant prostate cancer. Synonyms: 4-{3-[4(trifluoromethyl)phenyl]-5,5- bis(D3)methyl-4-oxo-2-sulfanylideneimidazolidin-1- yl}-2-fluorobenzoic acid -. Grade: 95% by HPLC; 98% atom D. Molecular formula: C20H7D6F4N3O3S. Mole weight: 457.43. | |
| Enzalutamide Impurity 1 | An impurity of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist in LNCaP cells. Synonyms: 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl]-2-fluoro-N,N-dimethylbenzamide. Grade: > 95%. Molecular formula: C22H18F4N4O2S. Mole weight: 478.47. | |
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