BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Elocalcitol | BXL 628 is a vitamin D3 analogue that competes with vitamin D receptor (VDR) for inhibition of prostate cell growth and RhoA/Rho-kinase signaling, a calcium sensitizing pathway. BXL 628 exhibits anti-proliferative and anti-inflammatory properties in benign prostatic hyperplasia (BPH) treatment. Uses: Potential treatment of benign prostatic hyperplasia (bph). Synonyms: BXL 628; BXL-628; Ro-26-9228; 1alpha-Fluoro-25-hydroxy-16,23E-diene-26,27-bishomo-20-epi-cholecalciferol. Grade: 99%. CAS No. 199798-84-0. Molecular formula: C29H43FO2. Mole weight: 442.65. |  |
| Elomotecan | Elomotecan (BN-80927) belongs to a novel family of camptothecin analogs, the homocamptothecins, developed on the concept of topoisomerase I (Topo I) inhibition and characterized by a stable seven-membered beta-hydroxylactone ring. Preclinical data reported here show that BN80927 retains Topo I poisoning activity in cell-free assay (DNA relaxation) as well as in living cells, in which in vivo complexes of topoisomerase experiments and quantification of DNA-protein-complexes stabilization, have confirmed the higher potency of BN80927 as compared with the Topo I inhibitor SN38. In addition, BN80927 inhibits Topo II-mediated DNA relaxation in vitro but without cleavable-complex stabilization, thus indicating catalytic inhibition. Moreover, a Topo I-altered cell line (KBSTP2), resistant to SN38, remains sensitive to BN80927, suggesting that a part of the antiproliferative effects of BN80927 are mediated by a Topo I-independent pathway. This hypothesis is also supported by in vitro data showing an antiproliferative activity of BN80927 on a model of resistance related to the noncycling state of cells (G(0)-G(1) synchronized). In cell growth assays, BN80927 is a very potent antiproliferative agent as shown by IC(50) values consistently lower than those of SN38 in tumor cell lines as well as in their related drug-resistant lines. BN80927 shows high efficiency in vivo in tumor xenograft studies using human androgen-independent prostate | |
| Elomotecan HCl salt | Elomotecan, also referred to BN 80927 and R 1559, characterized by a stable seven-membered beta-hydroxylactone ring, is a DNA topoisomerase inhibitor. In vivo elomotecan shows high efficiency in vivo in tumor xenograft studies using human androgen-independent prostate tumors PC3 and DU145. Synonyms: 220997-99-9; 220998-10-7 (Elomotecan free base); (5R)-9-chloro-5-ethyl-5-hydroxy-10-methyl-12-[(4-methylpiperidin-1-yl)methyl]-1,4,5,13-tetrahydro-3H,15H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione hydrochloride (1:1). Grade: >98%. CAS No. 220997-99-9. Molecular formula: C29H33Cl2N3O4. Mole weight: 558.5. | |
| Elotuzumab | Elotuzumab is a monoclonal antibody used in the treatment of multiple myeloma, a type of cancer that affects plasma cells in the bone marrow. It targets the SLAMF7 (Signaling Lymphocytic Activation Molecule Family member 7) protein found on the surface of myeloma cells and natural killer cells. Elotuzumab is typically used in combination with other drugs, such as lenalidomide and dexamethasone, to increase its effectiveness. It is administered via intravenous infusion and is used in patients who have received prior therapies for multiple myeloma. Synonyms: Elotuzumab (anti-SLAMF7); Immunoglobulin G1, anti-(human protein CS1) (human-mouse HuLuc63 heavy chain), disulfide with human-mouse HuLuc63 κ-chain, dimer; BMS 901608; Empliciti; HuLuc 63; PDL 063. CAS No. 915296-00-3. | |
| ELOVL1-IN-2 | ELOVL1-IN-2 is an inhibitor of ELOVL1 (elongation of very-long-chain-fatty acid 1). CAS No. 2761063-79-8. Molecular formula: C18H15FN2O. Mole weight: 294.3. | |
| Elpetrigine | Elpetrigine, also known as GW 273293 and JZP-4, has a blocking effect on calcium channels and potassium channels which has been in clinical bipolar disorders and epilepsy. Synonyms: 3-(2,3,5-trichlorophenyl)pyrazine-2,6-diamine; GW273293; GW-273293; GW 273293; JZP-4; JZP 4; JZP4; Elpetrigine. Grade: >98%. CAS No. 212778-82-0. Molecular formula: C10H7Cl3N4. Mole weight: 289.54. | |
| ELQ-300 | ELQ-300 is a potent and orally bioavailable antimalarial agent, and it is a novel inhibitor of the reductive (Qi) site of the cytochrome bc1 complex (complex III in the electron transport chain). Synonyms: ELQ300; ELQ 300; 6-Chloro-7-methoxy-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one. Grade: ≥98%. CAS No. 1354745-52-0. Molecular formula: C24H17ClF3NO4. Mole weight: 475.84. | |
| ELQ-422 | ELQ-422 acts as an inhibitor of the cytochrome bc1 complex in the mitochondrial electron transport chain, thereby inhibiting oxidative phosphorylation. Synonyms: Endochin-like quinolone-422; Ethyl (((6-fluoro-7-methoxy-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4-yl)oxy)methyl) carbonate. Molecular formula: C28H23F4NO7. Mole weight: 561.49. | |
| ELR510444 | ELR510444 is a potent microtube disruptor with potential anticancer activity. ELR510444 has potent microtubule-disrupting activity, causing a loss of cellular microtubules and the formation of aberrant mitotic spindles and leading to mitotic arrest and apoptosis of cancer cells. ELR510444 potently inhibited cell proliferation with an IC(50) value of 30.9 nM in MDA-MB-231 cells, inhibited the rate and extent of purified tubulin assembly, and displaced colchicine from tubulin, indicating that the drug directly interacts with tubulin at the colchicine-binding site. ELR510444 is not a substrate for the P-glycoprotein drug transporter and retains activity in βIII-tubulin-overexpressing cell lines, suggesting that it circumvents both clinically relevant mechanisms of drug resistance to this class of agents. ELR510444 also shows potent antitumor activity in the MDA-MB-231 xenograft model with at least a 2-fold therapeutic window. Synonyms: ELR510444; ELR-510444; ELR 510444. Grade: >98%. CAS No. 1233948-35-0. Molecular formula: C19H16N2O2S2. Mole weight: 368.47. | |
| Elranatamab | Elranatamab is a humanized bispecific IgG2 antibody targeting B cell maturation antigen on myeloma cells and CD3 on T cells. Elranatamab activates and directs T cells to induce a selective cytotoxic T cell response against myeloma cells. Synonyms: PF-06863135; PF 06863135; PF06863135. Grade: 95%. CAS No. 2408850-14-4. Molecular formula: C6440H9958N1738O2010S49. Mole weight: 145.5 kDa. | |
| Elsibucol | Elsibucol, a metabolically stable derivative of probucol, inhibits atherosclerosis and preserves endothelial healing following arterial injury. In vitro, elsibucol reduces vascular smooth muscle cell proliferation without affecting cell viability. Synonyms: 4-[2,6-ditert-butyl-4-[2-(3,5-ditert-butyl-4-hydroxyphenyl)sulfanylpropan-2-ylsulfanyl]phenoxy]butanoic acid; (4,2,6-di-tert-butyl-4-(1-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-1-methyl-ethylsulfanyl)-phenoxy-butyric acid); Elsibucol; AGI 1096; AGI1096; AGI-1096; Elsibucol; UNII-O7T92N1Y8T.elsibucol. Grade: >98%. CAS No. 216167-95-2. Molecular formula: C35H54O4S2. Mole weight: 602.94. | |
| Elsulfavirine | Elsulfavirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment and prevention of human immunodeficiency virus (HIV) infection. Uses: Anti-hiv agents. Synonyms: Elpida; Benzeneacetamide, 4-bromo-3-(3-chloro-5-cyanophenoxy)-N-[2-chloro-4-[[(1-oxopropyl)amino]sulfonyl]phenyl]-2-fluoro-; 4-Bromo-3-(3-chloro-5-cyanophenoxy)-N-[2-chloro-4-[[(1-oxopropyl)amino]sulfonyl]phenyl]-2-fluorobenzeneacetamide. Grade: ≥95%. CAS No. 868046-19-9. Molecular formula: C24H17BrCl2FN3O5S. Mole weight: 629.28. | |
| Eltanexor | Eltanexor (KPT-8602) is an investigational second-generation SINE compound. Eltanexor acts as an orally bioavailable XPO1 (also known as CRM1) inhibitor with IC50 values of 20-211?nM in 10 AML lines after 3 days exposure. Synonyms: KPT-8602; ONO-7706; ATG-016. Grade: ≥98%. CAS No. 1642300-52-4. Molecular formula: C17H10F6N6O. Mole weight: 428.29. | |
| ElteN378 | ElteN378 can inhibit FKBP12e. It can be used in the study of Alzheimer disease, Parkinson disease, Amyotrophic Lateral Sclerosis, proliferation disorders and cancer. Synonyms: (S)-1-(2-oxo-2-phenylacetyl)-N-(3-phenylpropyl)piperidine-2-carboxamide. Grade: 98%. CAS No. 1421366-99-5. Molecular formula: C23H26N2O3. Mole weight: 378.472. | |
| Eltoprazine | Eltoprazine belongs the phenylpiperazine class which is a serenic or antiaggressive agent. It acts as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor with Ki values of 40, 52 and 81 nM for 5-HT1A, 5-HT1B and 5-HT2C receptors respectively. It is closely related to fluprazine and batoprazine, which are similarly acting drugs. It has been shown to reduce L-DOPA-induced dyskinesias in experimental models of Parkinson's Disease and in human patients, although this effect was accompanied by a partial worsening of the therapeutic effect of l-dopa in vivo. It was found to (synergistically) potentiate the antidyskinetic effect of amantadine. It has been shown to reduce 5-HIAA levels in the striatum and exhibits antiaggressive behavior in vivo. It is used as a novel drug for the treatment of anxiety as well as other neurological and mental disorders. It was developed by PsychoGenics and Amarantus Bioscience, Inc. It is in clinical stage 3. Uses: Eltoprazine has been shown to reduce l-dopa-induced dyskinesias in experimental models of parkinson's disease and in human patients. it is used as a novel drug for the treatment of anxiety as well as other neurological and mental disorders. Synonyms: Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-; 1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine; DU-28853; DU28853. Grade: >98 %. CAS No. 98224-03-4. Molecular formula: C12H16N2O2. Mole weight: 220.27. | |
| Eltoprazine hydrochloride | Eltoprazine hydrochloride is the hydrochloride form of Eltoprazine which is a serenic or antiaggressive agent. It acts as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor with Ki values of 40, 52 and 81 nM for 5-HT1A, 5-HT1B and 5-HT2C receptors respectively. It has been shown to reduce L-DOPA-induced dyskinesias in experimental models of Parkinson's Disease and in human patients, although this effect was accompanied by a partial worsening of the therapeutic effect of l-dopa in vivo. It is used as a novel drug for the treatment of anxiety as well as other neurological and mental disorders. It was developed by PsychoGenics and Amarantus Bioscience, Inc. It is in clinical stage 3. Uses: Eltoprazine hydrochloride has been shown to reduce l-dopa-induced dyskinesias in experimental models of parkinson's disease and in human patients. it is used as a novel drug for the treatment of anxiety as well as other neurological and mental disorders. Synonyms: Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-, monohydrochloride; 1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine hydrochloride; DU-28853 hydrochloride; DU28853 hydrochloride. Grade: >98 %. CAS No. 98206-09-8. Molecular formula: C12H17N2O2Cl. Mole weight: 256.73. | |
| Eltrombopag | Eltrombopag is a member of the biarylhydrazone class, which is a nonpeptide agonist of the thrombopoietin receptor (TpoR). Uses: Nonpeptide thrombopoietin receptor agonist. Synonyms: SB-497115-GR, SB497115. Grade: >98%. CAS No. 496775-61-2. Molecular formula: C25H22N4O4. Mole weight: 442.47. | |
| Eltrombopag acyl-β-D-glucuronide | Eltrombopag acyl-β-D-glucuronide. Synonyms: 1-[3'-[(2Z)-2-[1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy[1,1'-biphenyl]-3-carboxylate] β-D-glucopyranuronic acid. Molecular formula: C31H30N4O10. Mole weight: 618.59. | |
| Eltrombopag Acyl Glucuronide | Eltrombopag Acyl Glucuronide. Synonyms: Eltrombopag metabolite M2. CAS No. 1396009-05-4. Molecular formula: C31H30N4O10. Mole weight: 618.6. | |
| Eltrombopag Amide | Eltrombopag Amide is a metabolite of Eltrombopag. Synonyms: 3'-[(2Z)-2-[1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-Biphenyl]-3-carboxamide. Grade: > 95%. CAS No. 1246929-02-1. Molecular formula: C25H23N5O3. Mole weight: 441.48. | |
| Eltrombopag Methyl Ester | Eltrombopag Methyl Ester is a metabolite of Eltrombopag. Synonyms: 3'-[(2Z)-2-[1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-Biphenyl]-3-carboxylic Acid Methyl Ester. Grade: > 95%. CAS No. 1246929-01-0. Molecular formula: C26H24N4O4. Mole weight: 456.49. | |
| Eltrombopag Olamine | Eltrombopag is a is an agonist of the c-mpl (TpoR) receptor used as treatment for thrombocytopenia.It has been developed for certain conditions that lead to thrombocytopenia (abnormally low platelet counts). Uses: C-mpl agonist. Synonyms: SB-497115-GR; 2-mainoethan-1-ol hemi((Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate). Grade: ≥98%. CAS No. 496775-62-3. Molecular formula: C29H36N6O6. Mole weight: 564.64. | |
| Elubrixin | Elubrixin is a interleukin 8 inhibitor and CXCR2 selective antagonist. It is potentially useful for Inflammatory bowel disease therapies. It inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans. It may be an effective agent in neutrophil-predominant diseases. It was developed by GlaxoSmithKline and was in clinic phase 2 trials, but now it is terminated. Uses: Elubrixin is potentially useful for inflammatory bowel disease therapies. it may be an effective agent in neutrophil-predominant diseases. Synonyms: 1-(2-Chloro-3-fluorophenyl)-3-(4-chloro-2-hydroxy-3-piperazin-1-ylsulfonylphenyl)urea; SB-656933; SB656933; SB-656933-AAF; SB-656933-AAA; SB656933AAA; SB656933AAF; 1-(4-Chloro-2-hydroxy-3-(piperazin-1-ylsulfonyl)phenyl)-3-(2-chloro-3-fluorophenyl)urea. Grade: 98%. CAS No. 688763-64-6. Molecular formula: C17H17Cl2FN4O4S. Mole weight: 463.30. | |
| Elubrixin tosylate | Elubrixin tosylate, a potent, selective, competitive, reversible and orally active antagonist of CXCR2 and IL-8 receptor, inhibits neutrophil CD11b upregulation (IC50 = 260.7 nM) and shape change (IC50 = 310.5 nM). It has potential in the study of inflammatory diseases, such as inflammatory bowel disease and airway inflammation. Synonyms: SB-656933 tosylate; N-[4-Chloro-2-hydroxy-3-[(piperazin-1-yl)sulfonyl]phenyl]-N'-(2-chloro-3-fluorophenyl)urea p-toluenesulfonate; 1-(2-Chloro-3-fluorophenyl)-3-[4-chloro-2-hydroxy-3-(1-piperazinylsulfonyl)phenyl]urea 4-methylbenzenesulfonate (1:1); Urea, N-(2-chloro-3-fluorophenyl)-N'-[4-chloro-2-hydroxy-3-(1-piperazinylsulfonyl)phenyl]-, 4-methylbenzenesulfonate (1:1). Grade: ≥95%. CAS No. 960495-43-6. Molecular formula: C24H25Cl2FN4O7S2. Mole weight: 635.51. | |
| Elucaine | Elucaine is a muscarinic acetylcholine receptor antagonist. It has anti-ulcerative activity. Synonyms: Elucaina; Benzenemethanol, alpha-((diethylamino)methyl)-, benzoate (ester). CAS No. 25314-87-8. Molecular formula: C19H23NO2. Mole weight: 297.40. | |
| Elunonavir | Elunonavir is an antiviral. Synonyms: dimethyl (3S,8S,9S,12S)-6-({4-[1-(difluoromethyl)-1H-pyrazol-3-yl]-2,6-difluorophenyl}methyl)-8-hydroxy-9-{[4-({2-[8-(oxetan-3-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl]pyrimidin-5-yl}ethynyl)phenyl]methyl}-4,11-dioxo-3,12-bis(1,1,1-trifluoro-2-methylpropan-2-yl)-2,5,6,10,13-pentaazatetradecane-1,14-dioate; methyl ((5S,8S,9S,14S)-11-(4-(1-(difluoromethyl)-1H-pyrazol-3-yl)-2,6-difluorobenzyl)-16,16,16-trifluoro-9-hydroxy-15,15-dimethyl-8-(4-((2-(8-(oxetan-3-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl)pyrimidin-5-yl)ethynyl)benzyl)-3,6,13-trioxo-5-(1,1,1-trifluoro-2-methylpropan-2-yl)-2-oxa-4,7,11,12-tetraazahexadecan-14-yl)carbamate. CAS No. 2242428-57-3. Molecular formula: C52H59F10N11O8. Mole weight: 1156.09. | |
| Elvitegravir | Elvitegravir is an HIV-1 integrase strand transfer inhibitor (INSTI) for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively. Uses: Anti-retroviral agents. Synonyms: GS-9137; GS 9137; GS9137; JTK-303; JTK 303; JTK303; EVG; D06677; D 06677; D-06677. Grade: ≥98%. CAS No. 697761-98-1. Molecular formula: C23H23ClFNO5. Mole weight: 447.88. | |
| Elzasonan citrate | Elzasonan citrate is a selective 5-hydroxytryptamine 1B receptor antagonist for treat patients with major depressive disorder and obsessive compulsive disorder. Uses: Serotonin 1b receptor antagonists; serotonin 1d receptor antagonists. Synonyms: (2Z)-4-(3,4-dichlorophenyl)-2-[[2-(4-methylpiperazin-1-yl)phenyl]methylidene]thiomorpholin-3-one; 2-hydroxypropane-1,2,3-tricarboxylic acid. Grade: ≥98%. CAS No. 361343-20-6. Molecular formula: C28H31Cl2N3O8S. Mole weight: 640.53. | |
| Elzasonan hydrochloride | Elzasonan, also called as CP 448187, exhibits potent and selective antagonism of 5-HT1B receptors in vitro, and preclinical in vivo studies demonstrate enhanced 5-HT neurotransmission. Elzasonan is able to improve signaling to limbic regions like the hippocampus and prefrontal cortex and ultimately resulting in antidepressant effects. Synonyms: (2Z)-4-(3,4-dichlorophenyl)-2-[[2-(4-methylpiperazin-1-yl)phenyl]methylidene]thiomorpholin-3-one; hydrochloride; Elzasonan hydrochloride; Elzasonan HCl; UNII-X38F62RR8L. Grade: >98%. CAS No. 220322-05-4. Molecular formula: C22H24Cl3N3OS. Mole weight: 484.86. | |
| Elzovantinib | Elzovantinib is a potent and orally available inhibitor of MET, CSF1R (colony stimulating factor 1 receptor) and SRC kinases. The simultaneous inhibition of MET, SRC and CSF1R kinases is a promising strategy for the treatment of MET-driven solid tumors. Synonyms: CSF1R-IN-2; TPX-0022. CAS No. 2271119-26-5. Molecular formula: C20H20FN7O2. Mole weight: 409.42. | |
| EM574 | EM574 is an agonist of motilin receptor with an IC50 value of 6.17 nM which binds to rabbit gastric antral smooth muscle homogenates in a radioligand binding assay. Synonyms: Idremcinal; 8,9-didehydro-N-demethyl-9-deoxo-6-deoxy-6,9-epoxy-N-(1-methylethyl)-erythromycin. Grade: ≥98%. CAS No. 110480-13-2. Molecular formula: C39H69NO12. Mole weight: 743.96. | |
| EM-651 | EM-651 is the enantiomer form of EM-652 which is an orally active pure antiestrogen and selective estrogen receptor antagonist with IC50=0.44nM. Synonyms: 2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-, (2R)-. CAS No. 182167-58-4. Molecular formula: C29H31NO4. Mole weight: 457.56. | |
| EMA401 | EMA401 is an orally bioavailable, potent and highly selective antagonist of the angiotensin II type 2 receptor (AT2; IC50s = 39.5 and 408,000 nM for rat recombinant AT2 and AT1, respectively). It inhibits capsaicin-induced calcium influx in cultured human dorsal root ganglion (hDRG) neurons (IC50 = 10 nM) and reduces neurite density and length in rat DRG neuronal cultures. Synonyms: EMA 401; EMA-401; Olodanrigan; (3S)-2-(2,2-diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinolinecarboxylic acid. Grade: ≥ 95 %. CAS No. 1316755-16-4. Molecular formula: C32H29NO5. Mole weight: 507.6. | |
| Emamectin | Emamectin, also called as Proclaim, is widely used as an insecticide because of its chloride channel activation property. Synonyms: (4''R)-4''-Deoxy-4''-(methylamino)avermectin B1; emamectin B1a. CAS No. 119791-41-2. Molecular formula: C49H75NO13. Mole weight: 886.133. | |
| Emamectin Benzoate | Emamectin Benzoate is the Emamectin derivative. Emamectin, also called as Proclaim, is widely used as an insecticide because of its chloride channel activation properties. Uses: Antiparasitic agents. Synonyms: Proclaim; Proclaim 5SG; Denim; Methylamino abamectin benzoate; Shot Wan; Denim (pesticide); Sch 58854; MK 244. Grade: 95.0% (sum of isomers, including Benzoate). CAS No. 155569-91-8. Molecular formula: C56H81NO15. Mole weight: 1008.24. | |
| Emapalumab | Emapalumab is an anti-interferon-gamma (IFNγ) monoclonal antibody approved for the treatment of primary hemophagocytic lymphohistiocytosis (HLH). Synonyms: Gamifant; NI-0501; NI 0501; NI0501. CAS No. 1709815-23-5. | |
| Emapunil | Exhibits high affinity for TSPO in rat whole brain (Ki = 0.297 nM), and high potency against human and rat glial TSPO (IC50 values are 2.73 and 3.04 nM respectively). Displays no noticeable binding to a number of other receptors, transporters or ion channels. Also displays anxiolytic and antidepressant effects in rodent models, without inducing benzodiazepine-like adverse effects. Synonyms: AC-5216; AC 5216; AC5216; XBD-173; XBD 173; XBD173; Emapunil. Grade: >98%. CAS No. 226954-04-7. Molecular formula: C23H23N5O2. Mole weight: 401.46. | |
| Emavusertib | Emavusertib is an orally bioavailable inhibitor of interleukin-1 receptor-associated kinase 4/FMS-like Tyrosine Kinase 3 (IRAK4/FLT3). Synonyms: CA-4948; CA 4948; CA4948. CAS No. 1801344-14-8. Molecular formula: C24H25N7O5. Mole weight: 491.50. | |
| Embusartan | Embusartan, an oxopyridine derivative, has been found to be an angiotensin II receptor antagonist that was once studied against hypertension by Bayer. Synonyms: Embusartan; UNII-4MY73645XA; Embusartan [INN]; Bay 10-6734; Bay-10-6734; methyl 2-butyl-1-[[2-fluoro-4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-6-oxopyridine-4-carboxylate. Grade: 98%. CAS No. 156001-18-2. Molecular formula: C25H24FN5O3. Mole weight: 461.49. | |
| EMD 281014 hydrochloride | EMD 281014 hydrochloride is a selective 5-HT2A antagonist with preference for human 5-HT2A over 5-HT2C receptors (Ki = 0.87 and 557 nM, respectively). EMD 281014 has the potential to treat insomnia. Uses: Potential treatment of insomnia. Synonyms: EMD 281014 hydrochloride; EMD281014 hydrochloride; EMD-281014 hydrochloride; Pruvanserin hydrochloride; Pruvanserin HCl; 7-[[4-[2-(4-Fluorophenyl)ethyl]-1-piperazinyl]carbonyl]-1H-indole-3-carbonitrile hydrochloride. Grade: ≥98% by HPLC. CAS No. 443144-27-2. Molecular formula: C22H21FN4O.HCl. Mole weight: 412.89. | |
| EMD 386088 | EMD 386088 is a potent 5-HT6 receptor partial agonist (Ki = 1 nM) used as an antidepressant. EMD-386088 is also a dopamine reuptake inhibitor. Synonyms: 1H-Indole, 5-chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-; 5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole; EMD-386088; EMD386088. Grade: ≥95%. CAS No. 54635-62-0. Molecular formula: C14H15ClN2. Mole weight: 246.74. | |
| EMD 386088 hydrochloride | EMD 386088 hydrochloride is a potent and selective 5-HT6 receptor agonist (EC50 = 1.0 nM) (IC50 = 7.4, 110, 180, 240, 450, 620, 660 and 3000 nM for 5-HT6, 5-HT1D, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT4, 5-HT1A and 5-HT7 receptors, respectively) used as an antidepressant. Synonyms: 1H-Indole, 5-chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-, hydrochloride (1:1); EMD386088 hydrochloride; EMD-386088 hydrochloride; 5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole hydrochloride. Grade: ≥99% by HPLC. CAS No. 1171123-46-8. Molecular formula: C14H15N2Cl.HCl. Mole weight: 283.20. | |
| EMD534085 | EMD534085 is a potent and selective mitotic kinesin-5 inhibitor with an IC50 of 8 nM. Synonyms: 1-(2-(Dimethylamino)ethyl)-3-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano(3,2-C)quinolin-2-yl)methyl)urea; EMD-534085; EMD 534085; N-[2-(Dimethylamino)ethyl]-N'-[[(2R,4aS,5R,10bS)-3,4,4a,5,6,10b-hexahydro-5-phenyl-9-(trifluoromethyl)-2H-pyrano[3,2-c]quinolin-2-yl]methyl]urea. Grade: ≥95%. CAS No. 858668-07-2. Molecular formula: C25H31F3N4O2. Mole weight: 476.53. | |
| EMD638683 | EMD638683 is a potent SGK1 inhibitor with an IC50 of 3 μM. Synonyms: EMD638683; EMD 638683; EMD-638683. Grade: >98%. CAS No. 1181770-72-8. Molecular formula: C18H18F2N2O4. Mole weight: 364.34. | |
| EMD638683 R-Form | EMD638683 (R-Form) is a SGK1 inhibitor with an IC50 of < 300 nM. Synonyms: EMD 638683 (R-Form); EMD638683 (R-Form); EMD-638683 (R-Form). Grade:>98%. CAS No. 1184940-47-3. Molecular formula: C18H18F2N2O4. Mole weight: 364.34. | |
| EMD638683 S-Form | EMD638683 (S-Form) is a SGK1 inhibitor with an IC50 of >300 nM. Synonyms: EMD 638683 (S-Form); EMD638683 (S-Form); EMD-638683 (S-Form). Grade: >98%. CAS No. 1184940-46-2. Molecular formula: C18H18F2N2O4. Mole weight: 364.34. | |
| EMD 66684 | EMD 66684 is a potent and selective non-peptide angiotensin AT1 receptor antagonist (IC50 = 0.7 and >10000 nM for AT1 and AT2 receptors, respectively). It inhibits isolated rabbit aorta contractions induced by angiotensin II (IC50 = 0.2 nM) and lowers blood pressure in hypertensive rats. Synonyms: 5H-Imidazo[4,5-c]pyridine-5-acetamide, 2-butyl-3,4-dihydro-N,N-dimethyl-4-oxo-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, potassium salt (1:1); Potassium 5-(4'-((2-butyl-5-(2-(dimethylamino)-2-oxoethyl)-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]pyridin-3-yl)methyl)-[1,1'-biphenyl]-2-yl)tetrazol-1-ide; 5H-Imidazo[4,5-c]pyridine-5-acetamide, 2-butyl-3,4-dihydro-N,N-dimethyl-4-oxo-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, potassium salt; EMD-66684; EMD66684. Grade: ≥95%. CAS No. 187683-79-0. Molecular formula: C28H29KN8O2. Mole weight: 548.69. | |
| EMD 66684 (hydrochloride) | EMD 66684 is a potent and selective non-peptide angiotensin AT1 receptor antagonist (IC50 = 0.7 and > 10000 nM for AT1 and AT2 receptors, respectively). It inhibits isolated rabbit aorta contractions induced by angiotensin II (IC50 = 0.2 nM) and lowers blood pressure in hypertensive rats. Synonyms: 5H-Imidazo[4,5-c]pyridine-5-acetamide, 2-butyl-3,4-dihydro-N,N-dimethyl-4-oxo-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, hydrochloride (1:1); 2-(3-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-oxo-3,4-dihydro-5H-imidazo[4,5-c]pyridin-5-yl)-N,N-dimethylacetamide hydrochloride; 2-Butyl-3,4-dihydro-N,N-dimethyl-4-oxo-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl-4-yl]methyl]-5H-imidazo[4,5-c]pyridine-5-acetamide hydrochloride. Grade: ≥98% by HPLC. CAS No. 1216884-39-7. Molecular formula: C28H30N8O2.HCl. Mole weight: 547.05. | |
| EMDT oxalate | EMDT oxalate is a selective 5-HT6 agonist (Ki = 16 nM at human 5-HT6 receptors) with antidepressant-like activity. It shows potency comparable to serotonin for the activation of adenylate cyclase. Synonyms: J-016404; J 016404; J016404; 2-Ethyl-5-methoxy-N,N-dimethyl-1H-indole-3-ethanamine oxalate. Grade: ≥98% by HPLC. CAS No. 263744-72-5. Molecular formula: C15H22N2O.C2H2O4. Mole weight: 336.38. | |
| Emedastine | Emedastine is a potent, high affinity and selective antagonist of histamine H1-receptor with Ki of 1.3 for H1-receptors while significantly weaker at H2- (K1 = 49,067 nM) and H3-receptors (Ki = 12,430 nM). Uses: Anti-allergic agents. Synonyms: 1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzimidazole. Grade: ≥97%. CAS No. 87233-61-2. Molecular formula: C17H26N4O. Mole weight: 302.41. | |
| Emedastine Difumarate | Emedastine is a H1 receptor antagonist. It is a second generation antihistamine. Emedastine can block the action of histamine that causes allergic symptoms. It can be used in eye drops to alleviate the symptoms of allergic conjunctivitis. Uses: Allergic conjunctivitis; allergic rhinitis; atopic dermatitis; dermatitis; urticaria. Synonyms: Emedastine fumarate; Rapimine; AL-3432A; DSSTox_CID_26911; KB 2413; KB-2413; KG 2413; KG-2413; Emadine; 1-(2-Ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazole Difumarat. Grade: 95%. CAS No. 87233-62-3. Molecular formula: C25H34N4O9. Mole weight: 534.56. | |
| Emeramide | Emeramide is a mercury chelator and an antioxidant, for the treatment of mercury poisoning. The molecule consists of two thiol groups and linked via a pair of amide groups. Synonyms: BDTH2; N,N'-bis(2-mercaptoethyl)isophthalamide; 1-N,3-N-bis(2-sulfanylethyl)benzene-1,3-dicarboxamide. Grade: >98%. CAS No. 351994-94-0. Molecular formula: C12H16N2O2S2. Mole weight: 284.39. | |
| Emerfetamab | Emerfetamab is a half-life extended anti-CD33 x anti-CD3 bispecific T-cell engager (BiTE) antibody. Emerfetamab has been investigated for the treatment of relapsed/?refractory acute myeloid leukemia (AML). Synonyms: AMG-673; AMG 673; AMG673. Grade: 95%. CAS No. 2250261-27-7. | |
| EMI1 | EMI1 is an EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S inhibitor. Synonyms: 3-(Benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone. Grade: 98% by HPLC. CAS No. 35773-42-3. Molecular formula: C20H18N2O3. Mole weight: 334.4. | |
| EMI56 | EMI56, a derivative of EMI1, inhibits EGFR triple mutants and has stronger effects on mutant EGFR than EMI1. Synonyms: 2H-1-Benzopyran-2-one, 3-(2-benzoxazolyl)-7-(diethylamino)-6-methyl-; 3-(1,3-Benzoxazol-2-yl)-7-(diethylamino)-6-methyl-2H-chromen-2-one. Grade: ≥98%. CAS No. 2414374-41-5. Molecular formula: C21H20N2O3. Mole weight: 348.40. | |
| Emibetuzumab | Emibetuzumab is a humanized monoclonal antibody targeting HGFR. Emibetuzumab induces internalization and degradation of MET, inhibiting proliferation of tumor cells with MET amplification and providing antitumor activity in xenograft models of NSCLC. Synonyms: LY2875358. CAS No. 1365287-97-3. | |
| Emicerfont | Emicerfont is a Corticotropin releasing factor receptor 1 antagonist. It can block the CRF1 receptor and so reduce ACTH release. It has been investigated for the treatment of irritable bowel syndrome (IBS) and alcoholism. In Feb 2008, GlaxoSmithKline completed enrolment in its Phase-II trial for Irritable bowel syndrome in the US and Canada. Uses: Irritable bowel syndrome (ibs) and alcoholism. Synonyms: GW876008; 1-{1-[1-(4-Methoxy-2-methylphenyl)-6-methyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyrazol-3-yl}imidazolidin-2-one; GW876008X; 2-Imidazolidinone, 1-[1-[2,3-dihydro-1-(4-methoxy-2-methylphenyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyrazol-3-yl]-. Grade: 98%. CAS No. 786701-13-1. Molecular formula: C22H24N6O2. Mole weight: 404.47. | |
| Emicizumab | Emicizumab is a bispecific monoclonal antibody that binds to both the activated coagulation factor IX and to factor X. Emicizumab has been used in the management and treatment of hemophilia A. Synonyms: Hemlibra. CAS No. 1610943-06-0. | |
| Emiglitate | Emiglitate is an α-glucosidase inhibitor that is a powerful inhibitor of glucose-induced insulin release.But no development was reported for the treatment of Diabetes mellitus. Uses: Diabetes mellitus. Synonyms: BAY o 1248; EINECS 279-613-2; Emiglitatum [Latin]; Emiglitate; UNII-PF8AB2IBUM; 1,5-Dideoxy-1,5-((2-(4-(ethoxycarbonyl)phenoxy)ethyl)imino)-D-glucitol. Grade: 98%. CAS No. 80879-63-6. Molecular formula: C17H25NO7. Mole weight: 355.38. | |
| Emivirine | Emivirine (MKC-442) is a non-nucleoside reverse transcriptase inhibitors (NNRTIs) with Ki values of 0.20 and 0.01 μM for dTTP- and dGTP-dependent DNA or RNA polymerase activity, respectively. Emivirine displays potent and selective anti-human immunodeficiency virus type 1 (HIV-1) activity. Uses: Reverse transcriptase inhibitors. Synonyms: Emivirine; Coactinon; MKC-442; I-EBU; 149950-60-7; 6-BENZYL-1-ETHOXYMETHYL-5-ISOPROPYLURACIL. Grade: 95%. CAS No. 149950-60-7. Molecular formula: C17H22N2O3. Mole weight: 302.372. | |
| Emixustat | Emixustat, a novel visual cycle modulator, is a nonretinoid compound that directly inhibits RPE65, but does not bind to RAR/RXR retinoid receptors or antagonize retinoid binding proteins. Synonyms: (1R)-3-amino-1-[3-(cyclohexylmethoxy)phenyl]propan-1-ol; ACU-4429; emixustat. CAS No. 1141777-14-1. Molecular formula: C16H25NO2. Mole weight: 263.38. | |
| Emixustat hydrochloride | The hydrochloride salt form of Emixustat which could effectively inhibit the production of 11-cis-retinol which is related to age-related macular degeneration. Uses: The hydrochloride salt form of emixustat which could effectively inhibit the production of 11-cis-retinol which is related to age-related macular degeneration. Synonyms: Emixustat (hydrochloride); UNII-AP4OF2M98B; AP4OF2M98B; EMIXUSTAT HYDROCHLORIDE; 1141934-97-5; Emixustat hydrochloride (USAN). Grade: 98%. CAS No. 1141934-97-5. Molecular formula: C16H26ClNO2. Mole weight: 299.84. | |
| EML-425 | EML-425, a diazinane derivative, has been found to be a CBP/p300 inhibitor that could probably be significant in studies of human leukemia cells. IC50: 1.1 and 2.9 μM, respectively. Synonyms: EML 425; EML-425; EML425; MolPort-042-624-542; BDBM50081125; AKOS027470241; 1,3-dibenzyl-5-[(4-hydroxy-2,6-dimethylphenyl)methylidene]-1,3-diazinane-2,4,6-trione. Grade: 98%. CAS No. 1675821-32-5. Molecular formula: C27H24N2O4. Mole weight: 440.49. | |
| EML4-ALK kinase inhibitor 1 | EML4-ALK kinase inhibitor 1 is a potent and active inhibitor of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), with an IC50 of 1 nM. Synonyms: EML4-ALK kinase inhibitor 1; 1373409-08-5; CHEMBL4441960; AKOS040733093; MS-30424; HY-111752; CS-0090752. Grade: 98%. CAS No. 1373409-08-5. Molecular formula: C31H46N8O3. Mole weight: 580.76. | |
| EML741 | EML741 is an inhibitor of histone lysine methyltransferase G9a/GLP, with an IC50 of 23 nM and a Kd of 1.13 μM for G9a. EML741 also inhibits DNMT1 (IC50 = 3.1 μM), with no effect on DNMT3a or DNMT3b. It has low cytotoxicity, cell membrane permeability and blood-brain barrier penetration. Synonyms: 2-Cyclohexyl-N-(1-isopropylpiperidin-4-yl)-7-methoxy-8-(3-(pyrrolidin-1-yl)propoxy)-3H-benzo[e][1,4]diazepin-5-amine; 2-Cyclohexyl-N-(1-isopropyl-4-piperidinyl)-7-methoxy-8-[3-(1-pyrrolidinyl)propoxy]-3H-1,4-benzodiazepin-5-amine; 3H-1,4-Benzodiazepin-5-amine, 2-cyclohexyl-7-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-8-[3-(1-pyrrolidinyl)propoxy]-. CAS No. 2328074-38-8. Molecular formula: C31H49N5O2. Mole weight: 523.75. | |
| Emlenoflast | MCC7840 is a sulfonylurea non-steroidal anti-inflammatory drug and a potent selective inhibitor of NLRP3 inflammasome with IC50 <100 nM. Synonyms: N-[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl]-1-(propan-2-yl)-1H-pyrazole-3-sulfonamide; Inzomelid; 1H-Pyrazole-3-sulfonamide, N-(((1,2,3,5,6,7-hexahydro-S-indacen-4-yl)amino)carbonyl)-1-(1-methylethyl)-; N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-1-isopropyl-1H-pyrazole-3-sulfonamide; MCC7840. CAS No. 1995067-59-8. Molecular formula: C19H24N4O3S. Mole weight: 388.48. | |
| Emlenoflast sodium | Emlenoflast sodium is a sulfonylurea non-steroidal anti-inflammatory drug and a potent selective inhibitor of NLRP3 inflammasome with IC50 <100 nM. Synonyms: MCC7840 sodium. Grade: 98%. CAS No. 2380032-29-9. Molecular formula: C19H23N4NaO3S. Mole weight: 410.47. | |
| Emopamil | Emopamil is a calcium channel blocker that can be used to prevent renal injury after warm & cold ischemia. Uses: Calcium channel blockers. Synonyms: Emopamil; 78370-13-5; Emopamil [INN]; Emopamilum [Latin]; Emopamilo [Spanish]. Grade: 95%. CAS No. 78370-13-5. Molecular formula: C23H30N2. Mole weight: 334.504. | |
| EMPA | EMPA is a potent and selective OX2 receptor antagonist (IC50 = 2.3 nM and 1900 nM for OX2 and OX1, respectively) with no activity at a panel of 80 receptors. EMPA blocks orexin-B- and orexin-A-invoked calcium mobilization in hOX2-expressing CHO cells (IC50 = 7.9 nM and 8.8 nM, respectively) and reverses orexin-B-induced hyperlocomotion in mice. Synonyms: N-Ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)-acetamide. Grade: ≥98% by HPLC. CAS No. 680590-49-2. Molecular formula: C23H26N4O4S. Mole weight: 454.54. | |
| Empagliflozin 2-O-β-D-glucuronide | Empagliflozin 2-O-β-D-glucuronide is an impurity of Empagliflozin, a medication indicated for type 2 diabetes treatment. Synonyms: (1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-2-O-β-D-glucopyranuronosyl-D-glucitol. Molecular formula: C29H35ClO13. Mole weight: 627.03. | |
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