BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Aurein-2.2 | Aurein-2.2 is an amphipathic alpha-helical antimicrobial peptide and nNOS inhibitor produced by Litoria aurea (Ranoidea aurea, Green and golden bell frog). It has antibacterial and anticancer activity. Synonyms: H-Gly-Leu-Phe-Asp-Ile-Val-Lys-Lys-Val-Val-Gly-Ala-Leu-Gly-Ser-Leu-NH2; glycyl-L-leucyl-L-phenylalanyl-L-alpha-aspartyl-L-isoleucyl-L-valyl-L-lysyl-L-lysyl-L-valyl-L-valyl-glycyl-L-alanyl-L-leucyl-glycyl-L-seryl-L-leucinamide; Aurein 2.2. Grades: >97%. Molecular formula: C76H131N19O19. Mole weight: 1615.00. |  |
| Aurein-2.3 | Aurein-2.3 is an antimicrobial peptide and nNOS inhibitor produced by Litoria aurea (Ranoidea aurea, Green and golden bell frog). It has antibacterial and anticancer activity. Synonyms: H-Gly-Leu-Phe-Asp-Ile-Val-Lys-Lys-Val-Val-Gly-Ala-Ile-Gly-Ser-Leu-NH2; glycyl-L-leucyl-L-phenylalanyl-L-alpha-aspartyl-L-isoleucyl-L-valyl-L-lysyl-L-lysyl-L-valyl-L-valyl-glycyl-L-alanyl-L-isoleucyl-glycyl-L-seryl-L-leucinamide; Aurein 2.3. Grades: ≥97%. Molecular formula: C76H131N19O19. Mole weight: 1615.00. | |
| Aurein-2.4 | Aurein-2.4 is an amphipathic alpha-helical antimicrobial peptide and nNOS inhibitor produced by Litoria aurea (Ranoidea aurea, Green and golden bell frog). It has antibacterial and anticancer activity. Synonyms: H-Gly-Leu-Phe-Asp-Ile-Val-Lys-Lys-Val-Val-Gly-Thr-Ile-Ala-Gly-Leu-NH2; glycyl-L-leucyl-L-phenylalanyl-L-alpha-aspartyl-L-isoleucyl-L-valyl-L-lysyl-L-lysyl-L-valyl-L-valyl-glycyl-L-threonyl-L-isoleucyl-L-alanyl-glycyl-L-leucinamide; Aurein 2.4. Grades: ≥96%. Molecular formula: C77H133N19O19. Mole weight: 1629.03. | |
| Aurein-2.5 | Aurein-2.5 is an antimicrobial peptide produced by Litoria raniformis (Southern bell frog) and Litoria aurea (Green and golden bell frog). It has antibacterial and anticancer activity. Synonyms: Aurein 2.5; H-Gly-Leu-Phe-Asp-Ile-Val-Lys-Lys-Val-Val-Gly-Ala-Phe-Gly-Ser-Leu-NH2; glycyl-L-leucyl-L-phenylalanyl-L-alpha-aspartyl-L-isoleucyl-L-valyl-L-lysyl-L-lysyl-L-valyl-L-valyl-glycyl-L-alanyl-L-phenylalanyl-glycyl-L-seryl-L-leucinamide. Grades: >98%. Molecular formula: C79H129N19O19. Mole weight: 1649.02. | |
| Aurein-2.6 | Aurein-2.6 is an antimicrobial peptide produced by Litoria raniformis (Litoria aurea, Southern bell frog). It has antibacterial and anticancer activity. Synonyms: Aurein 2.6; H-Gly-Leu-Phe-Asp-Ile-Ala-Lys-Lys-Val-Ile-Gly-Val-Ile-Gly-Ser-Leu-NH2; glycyl-L-leucyl-L-phenylalanyl-L-alpha-aspartyl-L-isoleucyl-L-alanyl-L-lysyl-L-lysyl-L-valyl-L-isoleucyl-glycyl-L-valyl-L-isoleucyl-glycyl-L-seryl-L-leucinamide. Grades: ≥97%. Molecular formula: C77H133N19O19. Mole weight: 1629.03. | |
| Aurein-3.1 | Aurein-3.1 is an antimicrobial peptide produced by Litoria raniformis (Southern bell frog) and Litoria aurea (Green and golden bell frog). It has antibacterial and anticancer activity. Synonyms: Aurein 3.1; Gly-Leu-Phe-Asp-Ile-Val-Lys-Lys-Ile-Ala-Gly-His-Ile-Ala-Gly-Ser-Ile-NH2. Grades: ≥97%. Molecular formula: C81H136N22O20. Mole weight: 1738.11. | |
| Aurein-3.2 | Aurein-3.2 is an antimicrobial peptide produced by Litoria raniformis (Southern bell frog) and Litoria aurea (Green and golden bell frog). It has antibacterial and anticancer activity. Synonyms: Aurein 3.2; H-Gly-Leu-Phe-Asp-Ile-Val-Lys-Lys-Ile-Ala-Gly-His-Ile-Ala-Ser-Ser-Ile-NH2; glycyl-L-leucyl-L-phenylalanyl-L-alpha-aspartyl-L-isoleucyl-L-valyl-L-lysyl-L-lysyl-L-isoleucyl-L-alanyl-glycyl-L-histidyl-L-isoleucyl-L-alanyl-L-seryl-L-seryl-L-isoleucinamide. Grades: ≥96%. Molecular formula: C82H138N22O21. Mole weight: 1768.14. | |
| Aurein-3.3 | Aurein-3.3 is an antimicrobial peptide produced by Litoria raniformis (Litoria aurea, Southern bell frog). It has antibacterial and anticancer activity. Synonyms: Aurein 3.3; Gly-Leu-Phe-Asp-Ile-Val-Lys-Lys-Ile-Ala-Gly-His-Ile-Val-Ser-Ser-Ile-NH2. Grades: ≥96%. Molecular formula: C84H142N22O21. Mole weight: 1796.19. | |
| Aurein-5.2 | Aurein-5.2 is an antimicrobial peptide produced by Litoria raniformis (Southern bell frog) and Litoria aurea (Green and golden bell frog). It has antibacterial activity. Synonyms: Aurein 5.2; Gly-Leu-Met-Ser-Ser-Ile-Gly-Lys-Ala-Leu-Gly-Gly-Leu-Ile-Val-Asp-Val-Leu-Lys-Pro-Lys-Thr-Pro-Ala-Ser-OH. Grades: ≥96%. Molecular formula: C110H194N28O32S. Mole weight: 2452.98. | |
| Aurelin | Aurelin is an antimicrobial peptide produced by Aurelia aurita (Moon jellyfish). It has antibacterial activity against the Gram-positive bacterium L.monocytogenes and the Gram-negative bacterium E.coli. Synonyms: Ala-Ala-Cys-Ser-Asp-Arg-Ala-His-Gly-His-Ile-Cys-Glu-Ser-Phe-Lys-Ser-Phe-Cys-Lys-Asp-Ser-Gly-Arg-Asn-Gly-Val-Lys-Leu-Arg-Ala-Asn-Cys-Lys-Lys-Thr-Cys-Gly-Leu-Cys (Disulfide bridge: Cys3-Cys33, Cys12-Cys37, Cys19-Cys40). Grades: >98%. Molecular formula: C176H284N60O54S6. Mole weight: 4296.93. | |
| Aureobasidin A | Aureobasidin A is a cyclic depsipeptide antibiotic isolated from the filamentous fungus Aureobasidium pullulans R106. It is an antifungal agent that inhibits phosphorylceramide synthase. Synonyms: Basifungin. CAS No. 127785-64-2. Molecular formula: C60H92N8O11. Mole weight: 1101.42. | |
| Aureobasidine A | Aureobasidine A is produced by the strain of Aureobasidium pullulans R106. A has strong activity against candida albicans, Cryptococcus neoformans, budding yeast, histocapsular clinophyte and other pathogenic fungi, and its activity exceeds that of amphotericin B in most cases. The effect on candidiasis is bactericidal, and the therapeutic effect on systemic candidiasis in mice is superior to fluconum and amphotericin B. Molecular formula: C60H92N8O11. Mole weight: 1101.42. | |
| Aureocin A53 | Aureocin A53 is an antimicrobial peptide produced by Staphylococcus aureus A53. It has antibacterial activity against Gram-positive bacteria: Listeria monocytogenes, Staphylococcus simulans (MIC=100 nM), Staphylococcus aureus (MRSA), Streptococcus agalactiae, Micrococcus luteus (MIC=0.15 nM). Synonyms: N-formylmethionine-Ser-Trp-Leu-Asn-Phe-Leu-Lys-Tyr-Ile-Ala-Lys-Tyr-Gly-Lys-Lys-Ala-Val-Ser-Ala-Ala-Trp-Lys-Tyr-Lys-Gly-Lys-Val-Leu-Glu-Trp-Leu-Asn-Val-Gly-Pro-Thr-Leu-Glu-Trp-Val-Trp-Gln-Lys-Leu-Lys-Lys-Ile-Ala-Gly-Leu; aucA. Grades: >85%. Molecular formula: C292H447N69O66S. Mole weight: 6012.27. | |
| Aureoquinone | Aureoquinone is produced by the strain of Aureobasidium sp. The IC50 (μg/mL) for inhibiting the activity of protease, including trypsin, papain, thermophilic protease, collagenase and pound-protease are 11.4?14.5?17.8?7.1?and 8.7 respectively. Synonyms: 2,5,7,8-tetrahydroxy-3,6-dimethylnaphthalene-1,4-dione. Molecular formula: C12H10O6. Mole weight: 250.20. | |
| Aureothin | Aureothin is produced by the strain of Streptomyces thioluteus 4-A-1 and Streptomyces sp. 58. An unusual pyranone metabolite; has broad biological actions including antitumour, antimicrobial and insecticidal activities; a potent inhibitor of helicobacter pylori. Synonyms: Distacin; Mycolutein. Grades: >95% by HPLC. CAS No. 2825-00-5. Molecular formula: C22H23NO6. Mole weight: 397.42. | |
| Aureothricin | Aureothricin is produced by the strain of Streptomyces celluloflavus. It was active against gram-positive bacteria, negative bacteria and Mycobacterium, and intraperitoneal injection could inhibit the increase of ascites in transplanted mice with Aldrin ascites carcinoma. Synonyms: Propionylpyrrothione; Farcinin. Grades: >98% by HPLC. CAS No. 574-95-8. Molecular formula: C9H10N2O2S2. Mole weight: 242.32. | |
| Aureusimine B | It is an inhibitor of the protease Calpain produced by the strain of Streptomyces sp. SC433. It is a small molecular weight monoketopiperazine formed non-ribosomally by the fusion of phenylalanine and valin. Synonyms: Phevalin; 3-(1-Methylethyl)-6-(phenylmethyl)-2(1H)-pyrazinone; 6-Benzyl-3-isopropylpyrazin-2-one. Grades: >95% by HPLC. CAS No. 170713-71-0. Molecular formula: C14H16N2O. Mole weight: 228.29. | |
| Aurintricarboxylic acid ammonium salt | Aurintricarboxylic acid ammonium salt (CAS# 569-58-4) is used in preparation method of amorphous silica-alumina catalyst for use in reaction of methanol and ammonia to produce monomethylamine, dimethylamine and trimethylamine. Synonyms: azane;5-[(3-carboxy-4-hydroxyphenyl)-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-2-hydroxybenzoic acid. CAS No. 569-58-4. Molecular formula: C22H23N3O9. Mole weight: 473.43. | |
| Auristatin E | Auristatin E is a synthetic analog of dolastatin 10. Auristatin E is a highly potent antimitotic agent.Auristatin E inhibits tubulin polymerization. Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity. Uses: Adcs cytotoxin. Synonyms: Auristatin E. Grades: ≥96.0% (HPLC). CAS No. 160800-57-7. Molecular formula: C40H69N5O7. Mole weight: 732.01. | |
| Auristatin F | Auristatin F, a synthetic analog of dolastatin 10, is a cytotoxic tubulin modifier with potent and selective antitumor activity. It is an MMAF analog and cytotoxin in Antibody-drug conjugates. Uses: Adcs cytotoxin. Synonyms: N,N-Dimethyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-L-phenylalanine; L-Valinamide, N,N-dimethyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-; N,N-Dimethyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S)-1-carboxy-2-phenylethyl]amino}-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl}-3-methoxy-5-methyl-1-oxo-4-heptanyl]-N-methyl-L-valinamide. Grades: ≥97% by HPLC. CAS No. 163768-50-1. Molecular formula: C40H67N5O8. Mole weight: 745.99. | |
| Aurodox | It is produced by the strain of Streptomyces goldiniensis var. goldiniensis. Aurodox is a polyketide antibiotic originally isolated from S. goldiniensis, which inhibits bacterial protein biosynthesis by interrupting the functional cycle of Elongation Factor-Tu (EF-Tu). Aurodox is a type 3 secretion system (T3SS) inhibitor and growth promotor in poultry. It is active against Gram-positive bacteria, including B. megaterium, B. anthracis, and M. hominis (MICs = 0.06, 0.6, and 3-10 μg/ml, respectively). Synonyms: Antibiotic X 5108; Goldinodox; Goldinomycin; 1-methyl-Mocimycin; Benzamide; CYT11387. Grades: ≥95%. CAS No. 12704-90-4. Molecular formula: C44H62N2O12. Mole weight: 810.97. | |
| Auroglaucin | It is produced by the strain of Aspergillus spp. Synonyms: 2-[(1E,3E,5E)-1,3,5-Heptatrienyl]-3,6-dihydroxy-5-(3-methyl-2-butenyl)benzaldehyde; Auroglaucine; 2-((1E,3E,5E)-hepta-1,3,5-trien-1-yl)-3,6-dihydroxy-5-(3-methylbut-2-en-1-yl)benzaldehyde. CAS No. 41451-81-4. Molecular formula: C19H22O3. Mole weight: 298.38. | |
| Aurora A Inhibitor I | Aurora A Inhibitor I is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM. It is 1000-fold more selective for Aurora A than Aurora B. Synonyms: TC-S 7010; TC S 7010; TCS7010. Grades: >98%. CAS No. 1158838-45-9. Molecular formula: C31H31ClFN7O2. Mole weight: 588.07. | |
| Aurora A inhibitor II | Aurora A inhibitor II is a potent and selective inhibitor of Aurora A kinase (AurA; IC50 = 4.3 nM). Synonyms: 4-[[2-[[4-[2-(4-acetyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-N-(2-chlorophenyl)-Benzamide. Grades: 99%. CAS No. 1158838-43-7. Molecular formula: C31H29ClFN7O3. Mole weight: 602.06. | |
| Aurora Kinase Inhibitor II | The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. Aurora kinase inhibitor II is a cell-permeable anilinoquinazoline that blocks the activity of Aurora A with IC50 of 0.39 μM. This compound has the ability to permeate the cell and is involved in the regulation of the cell cycle, particularly cell division. This compound has the ability to permeate the cell and is involved in the regulation of the cell cycle, particularly cell division. Synonyms: 4-(4?-Benzamidoanilino)-6,7-dimethoxyquinazoline. Grades: ≥98%. CAS No. 331770-21-9. Molecular formula: C23H20N4O3. Mole weight: 400.4. | |
| Aurora Kinase Inhibitor III | Aurora kinase inhibitor III is a potent ATP-competitive aurora related kinase inhibitor with IC50 of 42 nM. Aurora kinase inhibitor III is a cell-permeable, 2,4-dianilinopyrimidine compound which has been used to study a variety of tumor types. It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR (IC50s = 386, 3,550, 591, 1,980, 2,510, 887, and >10,000 nM, respectively). Aurora kinase protein levels are elevated in c-myc-driven B-cell lymphomas in both mice and humans. Study of the inhibition of Aurora kinase proteins could lead to potential treatments for malignancies. Synonyms: Aurora Kinase Inhibitor III; AKI-7169; AKI 7169; AKI7169. Grades: ≥98%. CAS No. 879127-16-9. Molecular formula: C21H18F3N5O. Mole weight: 413.4. | |
| Aurothioglucose | Aurothioglucose is used in the treatment of rheumatoid arthritis and psoriasis. Synonyms: Aurothioglucose; Solganal; SKF 10056; SKF-10056; SKF10056; gold thioglucose; Aurothioglucose hydrate. Grades: >98%. CAS No. 12192-57-3. Molecular formula: C6H11AuO5S. Mole weight: 392.18. | |
| Australifungin | Australifungin is produced by the strain of Sporormiella australis. As an inhibitor of Shinganine n-acyl-transferase, it has strong antifungal activity, with MIC of 0.015-0.5 μg/mL for candida, cryptococcus neoforme, saccharomyces cerescens and other fungi, and 0.125 ~ 1μg/ mL for aspergillus. Australian fennetol has a low antifungal effect. Molecular formula: C23H36O6. Mole weight: 408.53. | |
| Australine hydrochloride | Australine hydrochloride is a polyhydroxylated pyrrolizidine alkaloid that inhibits a-glucosidase, amyloglucosidase, and glucosidase I. Synonyms: 1H-Pyrrolizine-1,2,7-triol, hexahydro-3-(hydroxymethyl)-, (1R,2R,3R,7S,7aR)-, hydrochloride (1:1); (+)-Australine hydrochloride; (1R,2R,3R,7S,7aR)-3-(Hydroxymethyl)hexahydro-1H-pyrrolizine-1,2,7-triol hydrochloride (1:1). Grades: ≥95%. CAS No. 186766-07-4. Molecular formula: C8H15NO4.HCl. Mole weight: 225.67. | |
| Autocamtide 2 | Autocamtide 2 is a highly selective synthetic peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). It can be used in the CaMKII activity assay. Synonyms: Autocamtide II; H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu-OH; L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-arginyl-L-arginyl-L-glutaminyl-L-alpha-glutamyl-L-threonyl-L-valyl-L-alpha-aspartyl-L-alanyl-L-leucine. Grades: ≥95%. CAS No. 129198-88-5. Molecular formula: C65H118N22O20. Mole weight: 1527.77. | |
| Autocamtide 2, amide | Autocamtide 2, amide is a highly selective synthetic peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). It can be used in the CaMKII activity assay. Synonyms: Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu-NH2. Grades: ≥95%. Molecular formula: C65H119N23O19. Mole weight: 1526.79. | |
| Autocamtide-2-Related Inhibitory Peptide | Autocamtide-2-related inhibitory peptide is a highly selective, specific and potent inhibitor of calmodulin-dependent protein kinase II (CaM kinase II) with I50 value of 40 nM. It is selective over PKC, PKA and CaM kinase IV. Synonyms: AIP; [Ala9]-Autocamtide 2. Grades: ≥97% by HPLC. CAS No. 167114-91-2. Molecular formula: C64H116N22O19. Mole weight: 1497.74. | |
| Autocamtide-2-related inhibitory peptide, myristoylated | Autocamtide-2-related inhibitory peptide, myristoylated is a CaM kinase II inhibitor. It is an enhanced cell-permeable derivative of autocamtide-2-related inhibitory peptide. It blocks reinstatement of morphine-seeking behavior in vivo by pretreatment. Synonyms: AIP Myristoylated; Myr-AIP. Grades: >98%. CAS No. 201422-04-0. Molecular formula: C78H142N22O20. Mole weight: 1708.12. | |
| Autocamtide-2-related inhibitory peptide TFA | Autocamtide-2-related inhibitory peptide TFA is a highly selective, specific and potent inhibitor of calmodulin-dependent protein kinase II (CaM kinase II). Synonyms: H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH.TFA; L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-arginyl-L-arginyl-L-glutaminyl-L-alpha-glutamyl-L-alanyl-L-valyl-L-alpha-aspartyl-L-alanyl-L-leucine trifluoroacetic acid; Autocamtide-2-Related Inhibitory Peptide Trifluoroacetate; CaM kinase II inhibitor TFA salt. Grades: ≥98%. Molecular formula: C64H116N22O19.C2HF3O2. Mole weight: 1611.76. | |
| AUY954 | NVP-AUY954 is an orally-available, benzothiazole-based, monoselective agonist of the sphingosine-1-phosphate receptor 1 (S1P1) intended for the treatment of human autoimmune mediated inflammatory neuropathies. NVP-AUY954 efficacy has been correlated with an accumulation of plasmacytoid dendritic cells (pDC), which may have therapeutic value in the treatment of multiple sclerosis. Uses: Sphingosine 1 phosphate receptor modulators. Synonyms: AUY954; AUY-954 free base; 820240-77-5; CHEMBL4579553; 820240-77-5 (free base); 3-[[2-[4-phenyl-3-(trifluoromethyl)phenyl]-1-benzothiophen-5-yl]methylamino]propanoic acid; 3-(((2-(2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)benzo[b]thiophen-5-yl)methyl)amino)propanoic acid; N-[[2-[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]benzo[b]thien-5-yl]methyl]-beta-alanine; AUY 954; GTPL2925; SCHEMBL2237377; BCP33492; BDBM50507187; AKOS040750638; NVP-AUY954; AUY-954; AUY 954; Q27074628; 3-{[2-(2-trifluoromethyl-biphenyl-4-yl)benzo[b]thiophen-5-ylmethyl]amino}propionic acid. Grades: ≥98%. CAS No. 820240-77-5. Molecular formula: C25H20F3NO2S. Mole weight: 455.5. | |
| AV-412 | AV-412 is a second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may suppress tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization. Synonyms: AV 412; AV412; N-[4-(3-chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide. CAS No. 451492-95-8. Molecular formula: C27H28ClFN6O. Mole weight: 507.01. | |
| AV-412 Tosylate | AV-412 is a dual EGFR/ErbB2 kinase inhibitor. It completely inhibits the tumor growth of both H1650 and H1975 xenografts in nude mice. It is proved that AV-412 suppresses tumor growth via the inhibition of EGFR. Besides that, AV-412 also shows antitumor effects against various tumor models expressing EGFR, ErbB2 or both receptors, such as breast cancer KPL-4, prostate cancer DU145 and lung cancer LC-376. Uses: Antineoplastic agents. Synonyms: N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-methyl-3-(4-methylpiperazin-1-yl)but-1-yn-1-yl)quinazolin-6-yl)acrylamide bis(4-methylbenzenesulfonate); MP-412; MP 412; MP412; AV-412; AV 412; AV412; AV-412 tosylate. Grades: >98%. CAS No. 451493-31-5. Molecular formula: C41H44ClFN6O7S2. Mole weight: 851.41. | |
| Avagacestat | BMS-708163 is a potent and orally bioavailable inhibitor of γ-secretase that more potently inhibits the cleavage of APP (IC50 = 0.30 nM) to Aβ40 than signaling through Notch (IC50s = 58 nM). Uses: Gamma secretase inhibitors and modulators. Synonyms: Avagacestat; BMS 708163; (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide. Grades: >98%. CAS No. 1146699-66-2. Molecular formula: C20H17ClF4N4O4S. Mole weight: 520.89. | |
| Avanafil Impurity 13 | Avanafil Impurity 13 is an impurity of Avanafil, a medication prescribed for treating erectile dysfunction. Synonyms: 1,4,5,6-tetrahydropyrimidin-2-ylmethanamine; Avanafil Related Compound 1. Grades: > 95%. CAS No. 759408-08-7. Molecular formula: C5H11N3. Mole weight: 113.16. | |
| Avanafil metabolite M4 | Avanafil metabolite M4 is a major active metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil. Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites avanafil metabolite M4 and avanafil metabolite M16, as well as minor metabolites. Avanafil metabolite M4 inhibits PDE5 with 18% of the potency of avanafil. Grades: ≥98%. Molecular formula: C23H26ClN7O4. Mole weight: 499.95. | |
| Avanafil Related Compound 1 | Synonyms: 4-(3-chloro-4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylsulfinylpyriMidine; Ethyl 4-((3-chloro-4-Methoxybenzyl)aMino)-2-(Methylsulfinyl)pyriMidine-5-carboxylate. Grades: > 95%. CAS No. 330785-82-5. Molecular formula: C16H18ClN3O4S. Mole weight: 383.86. | |
| Avapritinib | BLU-285 is a potent and selective inhibitor of exon 17 mutant KIT (IC50 = 0.27 nM for KIT D816V). BLU-285 showed dose-dependent, robust anti-tumor efficacy in a TKI-resistant KIT exon 11/17 mutant GIST PDX model through inhibition of tumor growth, proliferation, KIT signaling and induction of apoptosis. Synonyms: (1S)-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine; BLU-285; BLU 285; BLU285; UNII-513P80B4YJ; SCHEMBL16652297. CAS No. 1703793-34-3. Molecular formula: C26H27FN10. Mole weight: 498.56. | |
| Avarofloxacin hydrochloride | Avarofloxacin hydrochloride is an antibacterial drug agent. Uses: Avarofloxacin hydrochloride is an antibacterial drug agent. Synonyms: Avarofloxacin HCl;JNJ-Q2 hydrochloride;7-[(3E)-3-(2-amino-1-fluoroethylidene)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid hydrochloride;JNJ-32729463 hydrochloride;JNJ 32729463 hydrochloride. Grades: >98 %. CAS No. 1001162-01-1. Molecular formula: C21H24ClF2N3O4. Mole weight: 455.89. | |
| Avatrombopag | Avatrombopag, also known as AKR-501, YM477, AS 1670542 or E5501, is a novel orally-active thrombopoietin (TPO) receptor agonist. AKR-501 specifically targeted the TPO receptor and stimulated megakaryocytopoiesis throughout the development and maturation of megakaryocytes just as rhTPO did. AKR-501 is an orally-active TPO receptor agonist that may be useful in the treatment of patients with thrombocytopenia. Synonyms: AKR-501; AKR 501; AKR501; YM477; YM-477; YM 477; E5501; AS 1670542; AS1670542; AS-1670542. Grades: 98%. CAS No. 570406-98-3. Molecular formula: C29H34Cl2N6O3S2. Mole weight: 649.65. | |
| Avatrombopag maleate | Avatrombopag, also known as AKR-501, YM477, AS 1670542 or E5501, is a novel orally-active thrombopoietin (TPO) receptor agonist. AKR-501 specifically targeted the TPO receptor and stimulated megakaryocytopoiesis throughout the development and maturation of megakaryocytes just as rhTPO did. AKR-501 is an orally-active TPO receptor agonist that may be useful in the treatment of patients with thrombocytopenia. CAS No. 677007-74-8. Molecular formula: C33H38Cl2N6O7S2. Mole weight: 765.7. | |
| AvBD10 | AvBD10 is an antimicrobial peptide produced by liver, Peking duck, Anas platyrhynchos (Domestic duck). It has antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Synonyms: Duck AvBD10; Duck avian beta defensin 10; Val-Leu-Leu-Phe-Leu-Phe-Gln-Ala-Ala-Pro-Gly-Ser-Ala-Asp-Ala-Pro-Phe-Ala-Asp-Thr-Ala-Ala-Cys-Arg-Ser-Gln-Gly-Asn-Phe-Cys-Arg-Ala-Gly-Ala-Cys-Pro-Pro-Thr-Phe-Ala-Ala-Ser-Gly-Ser-Cys-His-Gly-Gly-Leu-Leu-Asn-Cys-Cys-Ala-Lys. Grades: >98%. | |
| AVB-S6-500 | AVB-S6-500 is a GAS6-AXL signaling pathway blocker with high affnity for GAS6. AVB-S6-500 is developed for the treatment of cancer and nonmalignant fibrotic conditions as a drug candidate. It is in a phase I clinical trial for its safety and tolerability study. Uses: Potential treatment of cancer and nonmalignant fibrotic conditions. Synonyms: Aravive-S6. | |
| AVE 0991 | AVE 0991 is an agonist of nonpeptide Ang-(1-7) receptor Mas that has potential as a cardiovascular drug. Synonyms: 1-ethyl-3-[3-[4-[(5-formyl-4-methoxy-2-phenylimidazol-1-yl)methyl]phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylurea5-formyl-4-methoxy-2-phenyl-1-((4-(2-ethyl-aminocarbonylsulfonamido-5-isobutyl-3-thienyl)phenyl)methyl)imidiazoleAVE 0991; AVE-0991; AVE0991. CAS No. 304462-19-9. Molecular formula: C29H32N4O5S2. Mole weight: 580.72. | |
| AVE 0991 sodium salt | AVE 0991 sodium salt, is an agonist of nonpeptide Ang-(1-7) receptor Mas that has potential as a cardiovascular drug. Synonyms: AVE-0991 sodium salt; AVE 0991 sodium salt; AVE0991 sodium salt; sodium;ethylcarbamoyl-[3-[4-[(5-formyl-4-methoxy-2-phenylimidazol-1-yl)methyl]phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylazanideAVE 0991 (sodium salt)306288-04-0C29H31N4NaO5S23195AH. CAS No. 306288-04-0. Molecular formula: C29H31N4NaO5S2. Mole weight: 602.70. | |
| Avenaciolide | It is produced by the strain of Aspergillus avenaceus. A bicyclic bis-butyrolactone; isolated from aspergillus avenaceu; an antifungal agent; inhibits glutamate transport; an atypical ionophore. Synonyms: Avenaciolid; Furo(3,4-b)furan-2,6(3H,4H)-dione, dihydro-3-methylene-4-octyl- (VAN) (8CI). Grades: >95% by HPLC. CAS No. 20223-76-1. Molecular formula: C15H22O4. Mole weight: 266.33. | |
| Avenanthramide D | Synonyms: Avenanthramide 1p; Dianthramide P; N-p-Coumarylanthranilic acid; N-(E)-p-Coumaroylanthranilic acid. CAS No. 115610-36-1. Molecular formula: C16H13NO4. Mole weight: 283.28. | |
| Avena Sativa Kernel Extract | Avena Sativa Kernel Extract is a fully water-soluble botanical cosmetic raw material obtained from the kernel part of the gramineous plant oats. The main active ingredient is dextran, which is a kind of high saccharide, which can form a transparent, elastic and breathable film on the skin. Avena Sativa Kernel Extract can be used as a skin conditioner in cosmetics. Grades: 10:1. CAS No. 84012-26-0. | |
| Averantin | Averantin is an anthraquinone fungal metabolite produced by Aspergillus sp. associated with Panax notoginseng. It is a mycotoxic intermediate in the pathway to aflatoxin B1. It displays antifungal activity against Fusariumsolani (pathogenic fungus of P. notoginseng) with minimum inhibitory concentrations of 16-32 ug/mL. It also shows antibacterial activity against Bacillus subtilis with minimum inhibitory concentrations of 16-32 ug/mL. Synonyms: 1,3,6,8-Tetrahydroxy-2-[(1S)-1-hydroxyhexyl]-9,10-anthracenedione; (-)-Averantin; (S)-1,3,6,8-Tetrahydroxy-2-(1-hydroxyhexyl)-9,10-anthracenedione; 9,10-Anthracenedione, 1,3,6,8-tetrahydroxy-2-[(1S)-1-hydroxyhexyl]-; (1'S)-averantin; (S)-(-)-averantin; (S)-averantin. Grades: ≥95%. CAS No. 5803-62-3. Molecular formula: C20H20O7. Mole weight: 372.37. | |
| Avermectin A1a | Avermectin A1a is produced by the strain of Streptomyces avermitilis. It stimulates nerve cells to release Y-aminobutyric acid (GABA), which blocks the transmission of signals from the central nervous system to the motor nerve. It is not resistant to bacteria and fungi, but has strong activity to nematode parasites such as ancylostoma and Pteria, as well as insects such as flies. Abamectin B1a has the highest activity. Ivermectin obtained by catalytic hydrogenation contains 22 23- dihydroabamectin B1a (above 80%) and 22 23 dioxabamectin B1b (below 20%). Less active than B1a but less toxic. Used as repellent (subcutaneous or oral) for cattle, sheep and pigs, it is also effective against human filariasis. Synonyms: SCHEMBL1681257. CAS No. 65195-51-9. Molecular formula: C49H74O14. Mole weight: 887.10. | |
| Avermectin A2a | Avermectin A2a is produced by the strain of Streptomyces avermitilis. It stimulates nerve cells to release Y-aminobutyric acid (GABA), which blocks the transmission of signals from the central nervous system to the motor nerve. It is not resistant to bacteria and fungi, but has strong activity to nematode parasites such as ancylostoma and Pteria, as well as insects such as flies. Abamectin B1a had the highest activity. Ivermectin obtained by catalytic hydrogenation contains 22,23-dihydroabamectin B1a (above 80%) and 22,23 dioxabamectin B1b(below 20%). Less active than B1a but less toxic. Used as repellent (subcutaneous or oral) for cattle, sheep and pigs, it is also effective against human filariasis. Synonyms: Avermectin A1a; SCHEMBL1681224. CAS No. 50914-15-3. Molecular formula: C49H76O15. Mole weight: 905.12. | |
| Avermectin B1a | It is produced by the strain of Streptomyces avermitilis. Avermectin B1a is an antiparasitic agent that paralyzes nematodes without causing hypercontraction or flaccid paralysis. It is a macrocyclic lactone that makes up a large component of the anthelimintic Abamectin used to control parasitic nematodes in livestock. It also acts as an insecticide and acaricide. Uses: Active ingredient in some commercial ant bait traps. Synonyms: Abamectin B1a. Grades: >98%. CAS No. 65195-55-3. Molecular formula: C48H72O14. Mole weight: 873.08. | |
| Avermectin B1a aglycone | It is an acid degradation product produced by hydrolysis of the disaccharide unit of avermectin. It is an inhibitor of nematode larval development. It has no paralytic activity. It is an anthelmintic in animal health. Synonyms: (6R,13S,25R)-22,23-didehydro-5-O-demethyl-28-deoxy-6,28-epoxy-13-hydroxy-25-[(1S)-1-methylpropyl]-milbemycin B. Grades: >95% by HPLC. CAS No. 71828-14-3. Molecular formula: C34H48O8. Mole weight: 584.74. | |
| Avermectin B1a monosaccharide | It is an acid degradation product produced by selective hydrolysis of the terminal saccharide unit of avermectin. It is a potent inhibitor of nematode larval development. It has no paralytic activity. Synonyms: 4'-O-de(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-5-O-demethyl-avermectin A1a; 5-O-Demethyl-4'-O-de(2,6-dideoxy-3-O-methyl-α-L-glucopyranosyl)avermectin A1a; MSB 1a. Grades: >95% by HPLC. CAS No. 71831-09-9. Molecular formula: C41H60O11. Mole weight: 728.91. | |
| Avermectin B2a | Avermectin B2a is produced by the strain of Streptomyces avermitilis. It stimulates nerve cells to release Y-aminobutyric acid (GABA), which blocks the transmission of signals from the central nervous system to the motor nerve. It is not resistant to bacteria and fungi, but has strong activity to nematode parasites such as ancylostoma and Pteria, as well as insects such as flies. Abamectin B1a has the highest activity. Ivermectin obtained by catalytic hydrogenation contains 22 23- dihydroabamectin B1a (above 80%) and 22 23 dioxabamectin B1b (below 20%). Less active than B1a but less toxic. Used as repellent (subcutaneous or oral) for cattle, sheep and pigs, it is also effective against human filariasis. Synonyms: SCHEMBL1681286. CAS No. 65195-57-5. Molecular formula: C48H74O15. Mole weight: 891.09. | |
| Averufin | Averufin is produced by the strain of Asergillus sp. Ames tests showed a weak mutagenic effect. Synonyms: Averufine; 3,4,5,6-Tetrahydro-7,9,11-trihydroxy-2-methyl-2,6-epoxy-2H-anthra[2,3-b]oxocin-8,13-dione. CAS No. 14016-29-6. Molecular formula: C20H16O7. Mole weight: 368.34. | |
| Avibactam | Avibactam is a novel investigational non-beta-lactam beta-lactamase inhibitor that is being developed for possible use in combination with ceftaroline in the U.S. Avibactam does not have any intrinsic antibacterial activity in its own right, but appears to be capable of inhibiting beta-lactamase enzymes that belong to molecular classes A and C.Avibactam is useful for Antibiotics. Uses: Beta-lactamase inhibitors. Synonyms: Sulfuric acid mono[(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester; Avibactam free acid; [(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate. Grades: >98%. CAS No. 1192500-31-4. Molecular formula: C7H11N3O6S. Mole weight: 265.24. | |
| Avibactam Impurity 11 | Avibactam Impurity 11 is an impurity of Avibactam. Synonyms: Avibactam Impurity 11; 1416134-60-5; Ethyl 5-phenylmethoxyiminopiperidine-2-carboxylate; Avibactam Impurity 15; (S,E)-ethyl 5-((benzyloxy)imino)piperidine-2-carboxylate. Grades: > 95%. CAS No. 1416134-60-5. Molecular formula: C14H18N2O3. Mole weight: 262.31. | |
| Avibactam Impurity 3 | Avibactam Impurity 3 is an impurity of Avibactam. Synonyms: (2S,5R)-5-[(benzyloxy)amino]piperidine-2-carboxamide; 2-Piperidinecarboxamide, 5-[(phenylmethoxy)amino]-, (2S,5R)-; (2S,5R)-5-(benzyloxyamino)-piperidine-2-carboxylic acid amide; 5R-(5-Benzyloxyamino) L-Pipecolic Amide. Grades: > 95%. CAS No. 1416134-49-0. Molecular formula: C13H19N3O2. Mole weight: 249.32. | |
| Avibactam Impurity 6 | An impurity of Avibactam, a non-β lactam β-lactamase inhibitor that inactivates some β-lactamases. Synonyms: (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; (1R,2S,5R)-7-Oxo-6-(phenylmethoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide. Grades: >95%. CAS No. 1192651-49-2. Molecular formula: C14H17N3O3. Mole weight: 275.31. | |
| Avibactam Impurity 9 | Avibactam Impurity 9 is an impurity of Avibactam. Synonyms: Avibactam Intermediate; (2S,5R)-5-[(Phenylmethoxy)amino]-2-piperidinecarboxylic Acid Ethyl Ester Ethanedioate; (2S,5R)-Ethyl 5-((benzyloxy)amino)piperidine-2-carboxylate Oxalate. Grades: > 95%. CAS No. 1416134-48-9. Molecular formula: C17H24N2O7. Mole weight: 377.39. | |
| Avibactam Sodium, (+)- | An impurity of Avibactam, a non-β lactam β-lactamase inhibitor that inactivates some β-lactamases. Synonyms: (2R,5S)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo(3.2.1)octane-2-carboxamide monosodium salt. Grades: ≥95%. CAS No. 1383814-68-3. Molecular formula: C7H10N3NaO6S. Mole weight: 287.23. | |
| Avibactam Sodium Salt | Avibactam Sodium Salt, a novel non-?-lactam ?-lactamase inhibitor, binds covalently to Ambler class A ?-lactamases, including KPCs, Ambler class C and some class D b-lactamases. In combination with ceftazidime, Avibactam is a new drug application for avibactam , and was approved by the FDA on February 25, 2015, to treat complicated urinary tract and complicated intra-abdominal Infections caused by antibiotic resistant-pathogens. Avibactam has limited intrinsic antimicrobial activity but restores the in vitro activity of b-lactams including ceftazidime, ceftaroline, the active metabolite of ceftaroline fosamil, and aztreonam against ESBL-producing pathogens. Synonyms: sodium (2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[321]octan-6-yl sulfate; NXL104; NXL-104; NXL 104; Avibactam; Avibactam sodium. CAS No. 1192491-61-4. Molecular formula: C7H10N3NaO6S. Mole weight: 287.23. | |
| Avidinorubicin | Avidinorubicin is produced by the strain of Streptomyces avidinii. It has anti-gram positive and negative bacterial activity, and has cytotoxicity to tumor cells. Molecular formula: C60H86N4O22. Mole weight: 1215.34. | |
| Avilamycin A | Avilamycin A is produced by the strain of Streptomyces viridochromogenes NRRL 2860. It inhibits the binding of amino acid-based tRNA to the bacterial ribosome for 30S subunit and has anti-gram-positive bacterial activity. It has been tried as feed additive in animal feeding. Synonyms: Flambamycin, 23-deoxy-. CAS No. 69787-79-7. Molecular formula: C61H88Cl2O32. Mole weight: 1404.23. | |
| Avilamycin B | Avilamycin B is produced by the strain of Streptomyces viridochromogenes NRRL 2860. It inhibits the binding of amino acid-based tRNA to the bacterial ribosome for 30S subunit and has anti-gram-positive bacterial activity. It has been tried as feed additive in animal feeding. Grades: 95%. CAS No. 73240-30-9. Molecular formula: C59H84Cl2O32. Mole weight: 1376.19. | |
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