BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| AZD3965 | AZD3965 is a selective inhibitor of monocarboxylate transporter 1 (MCT1) with a binding affinity of 1.6 nM, which is 6-fold selective over MCT2 and does not inhibit MCT4 at 10 μM. Both lactate transport and cell growth are potently inhibited by AZD3965 in lymphoma cell lines that preferentially express MCT1. Lactate transport inhibition in some cell lines also induces a cytotoxic effect. In vitro combination studies show that lactate transport inhibition can enhance the induction of cell death by doxorubicin. Blocking lactate transport in vitro also leads to a rapid inhibition of glucose uptake in the Raji Burkitt's lymphoma cell line. In vivo, AZD3965 is well tolerated and induces a dose- and time-dependent accumulation of lactate in the tumors, suppresses tumor growth and in the Raji model potentiates the effects of Rituxan, doxorubicin and bendamustine. The selective inhibition of lactate transport by the MCT1 inhibitor AZD3965 offers a novel mechanism for targeting the metabolic phenotype in tumors that preferentially express MCT1. Synonyms: (S)-5-(4-hydroxy-4-methylisoxazolidine-2-carbonyl)-1-isopropyl-3-methyl-6-((3-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione; AZD3965; AZD-3965; AZD 3965. Grades: >98%. CAS No. 1448671-31-5. Molecular formula: C21H24F3N5O5S. Mole weight: 515.51. |  |
| AZD-4320 | AZD-4320 is a new type of BH3 analogue BCL2/BCLxL dual inhibitor. Synonyms: AZD4320. Grades: ≥98% by HPLC. CAS No. 1357576-48-7. Molecular formula: C45H48ClF3N4O7S3. Mole weight: 945.5. | |
| AZD-4547 | AZD4547 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. AZD4547 binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways, and, so, the inhibition of tumor cell proliferation and tumor cell death. Synonyms: AZD-4547; AZD 4547; AZD4547; N-{3-[2-(3,5-Dimethoxyphenyl)ethyl]-1h-Pyrazol-5-Yl}-4-[(3r,5s)-3,5-Dimethylpiperazin-1-Yl]benzamide. Grades: 98%. CAS No. 1035270-39-3. Molecular formula: C26H33N5O3. Mole weight: 463.582. | |
| AZD4573 | AZD-4573 (AZD4573) is a potent and selective inhibitor of CDK9, with fast-off binding kinetics and high selectivity versus other kinases. AZD4573 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II, leading to the inhibition of gene transcription of various anti-apoptotic proteins. Synonyms: AZD-4573; AZD 4573; (1S,3R)-3-acetamido-N-(5-chloro-4-(5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl)cyclohexane-1-carboxamide. Grades: ≥98%. CAS No. 2057509-72-3. Molecular formula: C22H28ClN5O2. Mole weight: 429.94. | |
| AZD-4635 | AZD-4635 is an orally available adenosine 2A receptor (A2AR) inhibitor. Synonyms: AZD-4635; AZD 4635; AZD4635; HTL-1071; HTL 1071; HTL1071; 6-(2-chloro-6-methylpyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine. CAS No. 1321514-06-0. Molecular formula: C15H11ClFN5. Mole weight: 315.736. | |
| AZD-4694 | AZD-4694 is a bio-active chemical compound and is used as a diagnostic imaging agent. It was developed by AstraZeneca. Synonyms: AZD 4694; AZD-4694; AZD4694; NAV4694; NAV 4694; NAV-4694; Flutafuranol; 2-(2-Fluoro-6-methylaminopyridin-3-yl)benzofuran-5-ol. Grades: >98%. CAS No. 1054629-49-0. Molecular formula: C14H11FN2O2. Mole weight: 258.25. | |
| AZD-5069 | AZD-5069 is a potent and selective CXCR2 antagonist with the potential to inhibit neutrophil migration into the airways in patients with COPD. AZD-5069 was shown to inhibit binding of radiolabeled CXCL8 to human CXCR2 with a pIC50 value of 9.1. Synonyms: AZD-5069; AZD 5069; AZD5069. Grades: 98%. CAS No. 878385-84-3. Molecular formula: C18H22F2N4O5S2. Mole weight: 476.51. | |
| AZD 5153 | AZD5153 is a potent, selective, and orally available inhibitor of the bromodomain and extraterminal (BET) Inhibitor. It can simultaneously bind two bromodomains in BRD4 with the IC50 value of 5 nM, which has been shown to increase antitumor activity in multiple xenograft models of acute myeloid leukemia, multiple myeloma, and diffuse large B cell lymphoma. AZD5153 also shows enhanced potency as a result of bivalent binding and a clear correlation between BRD4 activity and cellular potency. Synonyms: (3R)-4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidinyl]phenoxy]ethyl]-1,3-dimethyl-2-piperazinone; (3R)-4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]-1,3-dimethylpiperazin-2-one. Grades: ≥ 95 %. CAS No. 1869912-39-9. Molecular formula: C25H33N7O3. Mole weight: 479.57. | |
| AZD5153 6-Hydroxy-2-naphthoic acid | AZD5153 6-Hydroxy-2-naphthoic acid, a 6-hydroxy-2-naphthoic acid salt of AZD-5153, is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor possessing a bivalent binding mode (pKi = 8.3 for BRD4). Synonyms: AZD5153 6-Hydroxy-2-naphthoic acid; AZD 5153 6-Hydroxy-2-naphthoic acid; AZD-5153 6-Hydroxy-2-naphthoic acid; 6-hydroxynaphthalene-2-carboxylic acid;4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]-1,3-dimethylpiperazin-2-one. CAS No. 1869912-40-2. Molecular formula: C36H41N7O6. Mole weight: 667.75. | |
| AZD-5363 | AZD-5363 is an orally available inhibitor of the serine/threonine protein kinase AKT (protein kinase B) with potential antineoplastic activity. AZD-5363 binds to and inhibits all AKT isoforms. This agent may be used as monotherapy or combination therapy for a variety of human cancers. Synonyms: AZD5363; AZD 5363; Capivasertib. Grades: 98%. CAS No. 1143532-39-1. Molecular formula: C21H25ClN6O2. Mole weight: 428.9152. | |
| AZD-5423 | AZD-5423 is a nonsteroidal glucocorticoid. It is used to treat respiratory diseases and in particular chronic obstructive pulmonary disease. It was developed by AstraZeneca. Uses: Azd-5423 is used to treat respiratory diseases and in particular chronic obstructive pulmonary disease. Synonyms: AZD-5423; AZD 5423; AZD5423; UNII-641H0Q518W; 2,2,2-Trifluoro-N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-methoxyphenyl)-2-propanyl)acetamide. Grades: >98 %. CAS No. 1034148-04-3. Molecular formula: C25H21F4N3O3. Mole weight: 487.45. | |
| AZD5438 | AZD5438 is a potent inhibitor of cyclin-dependent kinase (cdk) 1, 2, and 9 (IC(50), 16, 6, and 20 nmol/L, respectively). Broad cdk inhibition may provide an effective method to impair the dysregulated cell cycle that drives tumorigenesis and AZD5438 has the pharmacologic profile that provides an ideal probe to test this premise. Synonyms: AZD5438; AZD-5438; AZD 5438. Grades: 0.98. CAS No. 602306-29-6. Molecular formula: C18H21N5O2S. Mole weight: 371.45664. | |
| AZD 5582 dihydrochloride | AZD 5582 dihydrochloride is a potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein. It can bind to the BIR3 domain of XIAP to prevent interaction with caspase-9. Synonyms: 3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide. Grades: ≥97%. CAS No. 1883545-51-4. Molecular formula: C58H78N8O8·2HCl. Mole weight: 1088.21. | |
| AZD-5904 | AZD-5904 is a potent orally bioavailable MPO inhibitor. It inhibited the isolated MPO enzyme with an IC50 value of 140 nM and was approximately equipotent in assays of rat and mouse MPO enzyme activity. It was used for multiple sclerosis and COPD and has been evaluated in single and multiple dose studies in healthy volunteers. Uses: Azd-5904 was used for multiple sclerosis and copd. Synonyms: AZ1, AZ 1 AZ-1; TX4; TX-4; TX 4; AZD-5904; AZD 5904; AZD5904. (S)-3-((tetrahydrofuran-2-yl)methyl)-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one. Grades: 98%. CAS No. 618913-30-7. Molecular formula: C10H12N4O2S. Mole weight: 252.29. | |
| AZD5991 | AZD5991 is a potent and selective Mcl-1 inhibitor with an IC50 of <3 nM in FRET assay for treatment of hematologic cancers. AZD5991 has high selectivity and affinity for Mcl-1 and is currently in clinical development. AZD5991 shows potent antitumor activity in vivo with complete tumor regression in several models of multiple myeloma and acute myeloid leukemia after a single tolerated dose as monotherapy or in combination with bortezomib or venetoclax. AZD5991 monotherapy caused apoptosis preferentially in hematological cell lines with 6/22 AML and 7/19 MM cell lines showing caspase EC50 values <100 nM. In solid tumor cell lines single agent activity was seen mostly in NSCLC and BrCa. Uses: Antineoplastic agents. Synonyms: AZD-5991; AZD 5991; AZD-5991 Racemate; 22H-9, 4, 8-(Metheniminomethyno)-14, 20:26, 23-dimetheno-10H, 20H-pyrazolo[4, 3-l][2, 15, 22, 18, 19]benzoxadithiadiazacyclohexacosine-32-carboxylic acid, 5-chloro-2,11,12,24,27,29-hexahydro-2,3,24,33-tetramethyl-. Grades: ≥98%. CAS No. 2143010-83-5. Molecular formula: C35H34ClN5O3S2. Mole weight: 672.26. | |
| AZD6482 | AZD6482 is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold more selective to PI3Kβ than PI3Kδ, PI3Kα and PI3K&gamma. Phase 1. Synonyms: KIN193; AZD6482; KIN 193; AZD 6482; KIN-193; AZD-6482. Grades: >98%. CAS No. 1173900-33-8. Molecular formula: C22H24N4O4. Mole weight: 408.45. | |
| AZD6482 (S-isomer) | This active molecular is the S-configuration isomer of AZD6482. AZD6482 is a selective, ATP competitive PI3Kβ inhibitor and IC50 value is 0.01 μm. Meanwhile, AZD6482 also inhibited insulin-induced human adipocyte glucose uptake in vitro and IC50 value is 4.4 μm. In May 2008, AstraZeneca completed a phase I trial in Thrombosis in Sweden. In Jul 2010, Phase-I for Thrombosis in Sweden was discontinued. Uses: Thrombosis. Synonyms: AZD6482 (S-isomer); AZD 6482 (S-isomer); AZD-6482 (S-isomer); (S)-2-((1-(7-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethyl)amino)benzoic acid,1173900-33-8 (AZD6482). Grades: 98%. CAS No. 1173900-37-2. Molecular formula: C22H24N4O4. Mole weight: 408.46. | |
| AZD6738 | AZD6738 is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM. Phase 1/2. Synonyms: AZD-6738; AZD 6738. Grades: 98%. CAS No. 1352226-88-0. Molecular formula: C20H24N6O2S. Mole weight: 412.51. | |
| AZD7507 | AZD7507 is a CSF-1R inhibitor with anti-tumor activity. Synonyms: AZD-7507; AZD 7507. Grades: >98%. CAS No. 1041852-85-0. Molecular formula: C23H27FN6O3. Mole weight: 454.5. | |
| AZD-7594 | AZD-7594 is an inhaled selective glucocorticoid receptor (GCCR) modulator. Synonyms: AZD-7594; AZD 7594; AZD7594; AZ13189620; AZ-13189620; AZ 13189620; 3-[5-[(1R,2S)-2-(2,2-difluoropropanoylamino)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)propoxy]indazol-1-yl]-N-[(3R)-oxolan-3-yl]benzamide. CAS No. 1196509-60-0. Molecular formula: C32H32F2N4O6. Mole weight: 606.627. | |
| AZD-7762 | AZD-7762 is a synthetic small molecule inhibitor of checkpoint kinases (Chks) with potential chemosensitizing activity. AZD7762 binds to and inhibits Chks, which may prevent cell cycle arrest and subsequent nucleotide excision repair in DNA-damaged tumor cells, resulting in tumor cell apoptosis. Synonyms: AZD 7762; AZD7762. Grades: 0.98. CAS No. 860352-01-8. Molecular formula: C17H19FN4O2S. Mole weight: 362.423. | |
| AZD 7762 hydrochloride | AZD 7762 hydrochloride is the hydrochloride salt of AZD 7762, which is a selective and potent ATP-competitive inhibitor of Chk1 and Chk2 with IC50 values of 5 nM for both kinases. It shows at least >10 fold selectivity over a panel of 164 kinases. It is used as a potentiation cytotoxicity DNA-damaging agent. It is active in vivo. Synonyms: AZD 7762 hydrochloride; AZD7762 hydrochloride; AZD-7762 hydrochloride; 5-(3-Fluorophenyl)-3-ureidothiophene-2-carboxylic acid N-[(S)-piperidin-3-yl]amide hydrochloride; 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-thiophenecarboxamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1246094-78-9. Molecular formula: C17H20FN4O2SCl. Mole weight: 398.88. | |
| AZD-8055 | AZD-8055 is an inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor AZD8055 inhibits the serine/threonine kinase activity of mTOR, resulting in decreased expression of mRNAs necessary for cell cycle progression, which may induce cell cycle arrest and tumor cell apoptosis. Synonyms: AZD8055; AZD-8055; AZD 8055. Grades: 0.98. CAS No. 1009298-09-2. Molecular formula: C25H31N5O4. Mole weight: 465.554. | |
| AZD8186 | AZD 8186 is a selective PI3Kβ/δ inhibitor (IC50= 0.003 μM for PI3Kβ, and 0.017 μM for PI3Kδ) with potential antineoplastic activity. It shows no significant binding against a panel of 442 other kinases when tested at a concentration of 10 μM and exhibits high oral efficacy in mouse cancer models. Synonyms: (R)-8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide; AZD8186; AZD 8186; AZD-8186. CAS No. 1627494-13-6. Molecular formula: C24H25F2N3O4. Mole weight: 457.4. | |
| AZD-8330 | AZD8330 is an orally active, selective MEK inhibitor with potential antineoplastic activity. AZD8330 specifically inhibits mitogen-activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. Synonyms: AZD8330; AZD-8330; AZD 8330; ARRY424704; ARRY 424704; ARRY-424704; ARRY704; ARRY-704; ARRY 704. Grades: 0.98. CAS No. 869357-68-6. Molecular formula: C16H17FIN3O4. Mole weight: 461.232. | |
| AZD-8835 | AZD-8835 was selected as a clinical candidate for the treatment of PIK3CA-dependent cancers and is currently in phase I clinical trials. It is an orally bioavailable inhibitor of the class I (PI3K) catalytic subunit alpha (PIK3CA). IC50: PI3Kδ= 5.7 nM, PI. Synonyms: 1-[4-[5-[5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl]-1-ethyl-1,2,4-triazol-3-yl]piperidin-1-yl]-3-hydroxypropan-1-one AZD-8835 1620576-64-8 GTPL8915 SCHEMBL15877923 AZD8835 ZGRDYKFVDCFJCZ-UHFFFAOYSA-N BDBM185362 AZD 8835 AKOS027338670 compo. CAS No. 1620576-64-8. Molecular formula: C22H31N9O3. Mole weight: 469.54. | |
| AZD-8931 | Sapitinib, also known as AZD-8931, is an erbB receptor tyrosine kinase inhibitor with potential antineoplastic activity. AZD8931 binds to and inhibits erbB tyrosine receptor kinases, which may result in the inhibition of cellular proliferation and angiogenesis in tumors expressing erbB. Synonyms: AZD8931; AZD 8931; Momelotinib; Sapitinib. Grades: 0.98. CAS No. 848942-61-0. Molecular formula: C23H25ClFN5O3. Mole weight: 473.933. | |
| AZD-9291 | AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. AZD 9291 is an irreversible inhibitor of epidermal growth factor receptor (EGFR) sensitizing and T790M resistance mutations (IC50s = 15-17 nM) while sparing the wild-type form of the receptor (IC50 = 480 nM). It binds the related IGF1R and hERG receptors with significantly reduced potency (IC50s = 2.9 and 16.2 μM, respectively). Uses: For research used only. Synonyms: Mereletinib; EGFR inhibitor; AZD9291; AZD 9291. Grades: 98%. CAS No. 1421373-65-0. Molecular formula: C28H33N7O2. Mole weight: 499.61. | |
| AZD9291DA | AZD9291-DA is a des acryl analogue of AZD9291, which is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. Uses: For research used only. Synonyms: AZD9291-Des acryl analogue; AZD9291 Des acryl precursor; Mutated EGFR-IN-1; N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine; N1-(2-dimethylaminoethyl)-5-methoxy-N1-methyl-N4-[4-(1-methylindol-3-yl)pyrimidin-2-yl]benzene-1,2,4-triamine; SCHEMBL14660679. Grades: 0.98. CAS No. 1421372-66-8. Molecular formula: C25H31N7O. Mole weight: 445.571. | |
| AZD-9291 mesylate | AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. It inhibits both activating and resistant EGFR mutations while sparing the normal form of EGFR that is present in normal skin and gut cells, thereby reducing the side effects encountered with currently available medicines. Synonyms: Mereletinib mesylate; EGFR inhibitor; AZD9291 mesylate; AZD 9291 mesylate. Grades: >98%. CAS No. 1421373-66-1. Molecular formula: C29H37N7O5S. Mole weight: 595.71. | |
| AZD9496 | AZD9496 is a potent and orally bioavailable selective estrogen receptor downregulator and antagonist. AZD9496 can induce ERα degradation in breast cancer cell lines at picomolar concentrations. Synonyms: (E)-3-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid; AZD9496; AZD-9496; AZD 9496. Grades: 98%. CAS No. 1639042-08-2. Molecular formula: C25H25F3N2O2. Mole weight: 442.48. | |
| Az-ddCTP-10 mM aqueous solution | Az-ddCTP-10 mM aqueous solution is an aqueous solution constituted by Azido-deoxy Cytidine Triphosphate (Az-ddCTP), which is a remarkable nucleotide analog. This solution empowers researchers in virology and antiviral drug development by effectively hindering viral replication. By seamlessly incorporating itself into the viral DNA chain during replication is az-ddCTP orchestrates premature termination, thereby rendering it an indispensable tool in this scientific domain. Synonyms: 3'-Azido-ddCTP.Li; 3'-Azido-2',3'-dideoxycytidine-5'-triphosphate lithium salt; AZddCTP. Grades: 90%. Molecular formula: C9H15O12N6P3·xLi. Mole weight: 492.17 (free acid). | |
| Az-ddTTP-100 mM aqueous solution | Az-ddTTP-100 mM aqueous solution is an indispensable and highly regarded recompound within the biomedical realm, emerging as a pivotal tool revolutionizing DNA sequencing methodologies. This superlative solution facilitates the meticulous investigation and research of multifaceted afflictions encompassing malignant neoplasms and hereditary maladies. Synonyms: 3'-Azido-ddTTP.Li; 3'-Azido-2',3'-dideoxythymidine-5'-triphosphate lithium salt; AzddTTP. Grades: 98%. Molecular formula: C10H16N5O13P3·xLi. Mole weight: 507.18 (free acid). | |
| Az-ddUTP-100 mM aqueous solution | Az-ddUTP-100 mM aqueous solution is a valuable tool in biomedical research acting as a substrate for reverse transcriptase to facilitate the introduction of azide-modified deoxyuridine triphosphate (ddUTP) into cDNA. This compound enables efficient labeling of RNA transcripts during in vitro transcription reactions. It finding applications in drug discovery, gene expression analysis is and understanding diseases at the molecular level. Synonyms: 3'-Azido-ddUTP.Li; 3'-Azido-2',3'-dideoxyuridine-5'-triphosphate lithium salt; AzddUTP. Molecular formula: C9H14N5O13P3·xLi. Mole weight: 493.15 (free acid). | |
| Azelaic acid | Azelaic acid, produced by ozone cracking of unsaturated fatty acid, could be commonly used in grease, cosmetics and pharmaceuticals. Uses: Azelaic acid could be produced by ozone cracking of unsaturated fatty acid and is commonly used in grease, cosmetics and pharmaceuticals. Synonyms: Finacea; Anchoic acid. Grades: > 98 %. CAS No. 123-99-9. Molecular formula: C9H16O4. Mole weight: 188.22. | |
| Azelaic acid-[13C2] | Azelaic acid-[13C2] is a labelled compound of Azelaic acid. Azelaic acid, produced by ozone cracking of unsaturated fatty acid, could be commonly used in grease, cosmetics and pharmaceuticals. Synonyms: (1,9-13C2)nonanedioic acid. Grades: > 98%. Molecular formula: C7[13C]2H16O4. Mole weight: 190.21. | |
| Azelaic acid-[13C9] | Azelaic acid-[13C9] is a labelled analogue of Azelaic acid, a bioactive molecule used in treating acne and other skin disorders. Synonyms: Azelaic acid-13C9; Nonanedioic-13C9 Acid. Grades: 98% (CP); 99% atom 13C. CAS No. 1262769-57-2. Molecular formula: [13C]9H16O4. Mole weight: 197.15. | |
| Azelaoyl PAF | Azelaoyl-PAF is an alkyl phosphatidylcholine and is a component of the lipid pool within oxidized low-density lipoprotein (oxLDL) particles, which contain low molecular weight species. It is a potent PPARγ agonist which competes for the thiazolidinedione binding site. Synonyms: 1-hexadecyl-2-azelaoyl-sn-glycero-3-phosphocholine; C16-09:0 (COOH) PC; 1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine; 1-O-Hexadecyl-2-O-(9-carboxyoctanoyl)-sn-glyceryl-3-phosphocholine. Grades: >99%. CAS No. 354583-69-0. Molecular formula: C33H66NO9P. Mole weight: 651.85. | |
| Azelastine HCl | Azelastine HCl is a potent, second-generation, selective, histamine antagonist. It inhibits histamine via competing with histamine for the H1 receptor. Uses: Histamine antagonist. Synonyms: ZELASTINE HYDROCHLORIDE; AC1Q1SYE; HYDROGEN AZELASTINE CHLORIDE; AKOS026749829; DR002552. Grades: >98%. CAS No. 79307-93-0. Molecular formula: C22H25Cl2N3O. Mole weight: 418.36. | |
| Azelastine HCl Impurity B | Azelastine HCl Impurity B is an intermediate in the preparation of Azelastine. Synonyms: Azelastine Related Compound B; 1-Methyl-4-(2-benzoylhydrazino)azapan hydrochloride; N'-(1-Methylazepan-4-yl)benzohydrazide hydrochloride; Benzoic acid 2-(hexahydro-1-methyl-1H-azepin-4-yl)hydrazide hydrochloride. Grades: > 95%. CAS No. 117078-69-0. Molecular formula: C14H22N3OCl. Mole weight: 283.80. | |
| Azelastine Impurity C | Azelastine Impurity C is an impurity of Azelastine. Synonyms: 2-((4-Chlorophenyl)acetyl)benzoic acid; 2-[2-(4-Chlorophenyl)acetyl]benzoic acid; Einecs 258-444-8. Grades: > 95%. CAS No. 53242-76-5. Molecular formula: C15H11ClO3. Mole weight: 274.71. | |
| Azelastine Impurity D | Azelastine Impurity D serves as an impurity standard of azelastine, a drug commonly prescribed to treat allergic rhinitand conjunctivitis. Grades: > 95%. CAS No. 53242-89-9. Molecular formula: C15H11ClN2O. Mole weight: 270.72. | |
| Azelastine Impurity E | Azelastine Impurity E is an impurity arising in the synthesis of azelastine. It is a stilbene-related benzalphthalide derivative with with potential anti-HIV and leishmanicidal activity. Synonyms: 3-[(4-chlorophenyl)methylene]phthalide; 3-[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-3H-isobenzofuran-1-one; 3-(4-Chlorobenzal)phthalide; 4-Chlorobenzylidene phthalide. Grades: > 95%. CAS No. 20526-97-0. Molecular formula: C15H9ClO2. Mole weight: 256.69. | |
| Azelastine-N-Oxide | Azelastine-N-Oxide is a metabolite of Azelastine. Synonyms: Azelastine N-Oxide (Mixture of DiastereoMers); 4-[(4-Chlorophenyl)Methyl]-2-(hexahydro-1-Methyl-1-oxido-1H-azepin-4-yl)-1(2H)-phthalazinone. Grades: > 95%. CAS No. 640279-88-5. Molecular formula: C22H24ClN3O2. Mole weight: 397.91. | |
| Azeliragon | Azeliragon is a potent and orally active RAGE inhibitor as a potential treatment for patients with mild-to-moderate Alzheimer's disease (AD). Uses: A potent and orally active rage inhibitor. Synonyms: TTP488; PF04494700; TTP 488; PF0 4494700; TTP-488; PF-044947003-[4-[2-Butyl-1-[4-(4-chlorophenoxy)phenyl]-1H-imidazol-4-yl]phenoxy]-N,N-diethyl-1-propanamine. Grades: ≥98%. CAS No. 603148-36-3. Molecular formula: C32H38ClN3O2. Mole weight: 532.124. | |
| Azelnidipine | Azelnidipine is a dihydropyridine calcium channel blocker. Synonyms: CS 905; CS-905; CS905; CCRIS 8650; CCRIS8650; CCRIS-8650; Azelnidipine; brand name CalBlock. UR-12592; UR 12592; UR12592. Grades: >98%. CAS No. 123524-52-7. Molecular formula: C33H34N4O6. Mole weight: 582.65. | |
| Azide-PEG2-Ms | Azide-PEG2-Ms is a polyethylene glycol (PEG)-based PROTAC linker. Azide-PEG2-Ms can be used in the synthesis of a series of PROTACs. Grades: 98%. CAS No. 176520-23-3. Molecular formula: C5H11N3O4S. Mole weight: 209.22. | |
| Azide-PEG4-aminoallyl-dUTP | Azide-PEG4-aminoallyl-dUTP is a dUTP analog that can be incorporated into DNA/cDNA by PCR with Taq polymerase. It is a reagent for DNA labeling with click chemistry. Synonyms: 5-(15-Azido-4,7,10,13-tetraoxa-pentadecanoyl-aminoallyl)-2'-deoxyuridine-5'-triphosphate, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C23H39N6O19P3 (free acid). Mole weight: 796.51 (free acid). | |
| Azido 2-Acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-galactopyranosyl | An intermediate useful in carbohydrate chemistry. Synonyms: Azido 2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl 3,4,6-Triacetate. CAS No. 39541-20-3. Molecular formula: C14H20N4O8. Mole weight: 372.33. | |
| azido-FTY720 | Fingolimod (FTY720) is an FDA approved immunomodulatory drug for treating multiple sclerosis that inhibits lymphocyte egress from lymphoid tissues by down-regulating sphingosine-1 phosphate receptor (S1PR). Phosphorylation of FTY270 by sphingosine kinase can cause S1P1R internalization, which sequesters lymphocytes in lymph nodes, preventing them from taking part in an autoimmune response. It is a first-in-class orally bioavailable compound that has shown efficacy in advanced clinical trials for the treatment of multiple sclerosis (MS). Synonyms: azido-FTY720; 881914-35-8; 2-Amino-2-[2-(3-azido-4-octylphenyl)ethyl]-1,3-propanediol; 2-amino-2-[2-(3-azido-4-octylphenyl)ethyl]propane-1,3-diol; 1,3-Propanediol, 2-amino-2-[2-(3-azido-4-octylphenyl)ethyl]-; AKOS040755896; HY-134976; CS-0168486. Grades: ≥98%. CAS No. 881914-35-8. Molecular formula: C19H32N4O2. Mole weight: 348.5. | |
| Azido-PEG2000-Carboxy | Synonyms: azido-polyethylene glycol(2000)-carboxylic acid. Grades: >99%. CAS No. 139747-01-6. Molecular formula: (C2H4O)nC4H7N3O3. Mole weight: 2039.38. | |
| Azido-PEG2-NHS ester | Azido-PEG2-NHS ester is a non-cleavable 2-unit PEG linker that can be used to synthesize antibody-conjugated drugs (ADCs). Synonyms: Azido-PEG2-CH2CO2-NHS; N3-PEG2-C2-NHS ester; Propanoic acid, 3-[2-(2-azidoethoxy)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester; N3-PEG2-CH2CH2COONHS Ester; Azido-PEG2-NHS; N3-PEG2-SPA; 1-({3-[2-(2-Azidoethoxy)ethoxy]propanoyl}oxy)-2,5-pyrrolidinedione; 2,5-Pyrrolidinedione, 1-[3-[2-(2-azidoethoxy)ethoxy]-1-oxopropoxy]-; 2,5-Dioxo-1-pyrrolidinyl 3-[2-(2-azidoethoxy)ethoxy]propanoate; N-Succinimido 9-azido-4,7-dioxanonanoate. Grades: ≥98%. CAS No. 1312309-64-0. Molecular formula: C11H16N4O6. Mole weight: 300.27. | |
| Azido-PEG3-aldehyde | A heterobifunctional linker with alkyne and hydroxyamine/hydrazine reactivity. Synonyms: 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanal; N3-PEG3-pALD. Grades: >95%. Molecular formula: C16H22N4O5. Mole weight: 350.37. | |
| Azido-PEG4-alcohol | It is useful as a spacer and linker between compounds. Synonyms: Azido-PEG4-alcohol. Grades: ≥ 96 %. CAS No. 86770-67-4. Molecular formula: C8H17N3O4. Mole weight: 219.24. | |
| Azido-PEG9-alcohol | Azido-PEG9-alcohol is a polyethylene glycol (PEG)-based PROTAC linker. Azido-PEG9-alcohol can be used in the synthesis of a series of PROTACs. Synonyms: N3-PEG9-OH. Grades: >97%. CAS No. 1984776-37-5. Molecular formula: C18H37N3O9. Mole weight: 439.50. | |
| Azido sphingosine (d14:1) | Synonyms: (2S,3R,E)-2-amino-14-azidotetradec-4-ene-1,3-diol. CAS No. 1417790-97-6. Molecular formula: C14H28N4O2. Mole weight: 284.40. | |
| Azidothymidine-5'-triphosphate (triethylammonium salt form) | The triethylammonium salt form of Azidothymidine-5'-triphosphate. Azidothymidine-5'-triphosphate is an inhibitor of human immunodeficiency virus type 1 and cellular DNA polymerase gamma. Synonyms: AzTTP (triethylammonium salt form); Zidovudine triphosphate (triethylammonium salt form). Grades: 95%. Molecular formula: C10H16N5O13P3.C6H15N. Mole weight: 507.184 (free acid). | |
| Azilsartan Amide Medoxomil | Azilsartan Amide Medoxomil is an impurity of Azilsartan, an angiotensin II receptor blocker (ARB) used to treat high blood pressure. Synonyms: (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-carbamoyl-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate; 1-[[2'-(Aminocarbonyl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic Acid (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl Ester. CAS No. 1696392-12-7. Molecular formula: C29H25N3O7. Mole weight: 527.52. | |
| Azilsartan-[d5] | Azilsartan-[d5] is the labelled analogue of Azilsartan, which is an angiotensin II type 1 receptor antagonist and could be used against hypertension and inflammation. Synonyms: Azilsartan D5; 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-(ethoxy-d5)-1H-benzimidazole-7-carboxylic Acid; 2-(Ethoxy-d5)-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic Acid; TAK 536-d5; Azilsartan O-Ethyl-d5. Grades: ≥98% by HPLC; ≥99% atom D. CAS No. 1346599-45-8. Molecular formula: C25H15D5N4O5. Mole weight: 461.48. | |
| Azilsartan Dimer | Azilsartan Dimer is an impurity of Azilsartan, an angiotensin II receptor blocker (ARB) used to treat high blood pressure. Synonyms: diethyl-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-4,5-dicarboxylate. CAS No. 1604812-35-2. Molecular formula: C35H28N4O11. Mole weight: 680.62. | |
| Azilsartan Hydroxy Acid | Azilsartan Hydroxy Acid is an impurity of Azilsartan, an angiotensin II receptor blocker (ARB) used to treat high blood pressure. Synonyms: (Z)-2-ethoxy-1-((2'-(N'-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid. CAS No. 1397836-49-5. Molecular formula: C24H22N4O4. Mole weight: 430.46. | |
| Azilsartan Impurity 1 | Cas No. 139481-44-0. | |
| Azilsartan Impurity A | Azilsartan Impurity A is an impurity of Azilsartan belonging to the venerated echelons of the hypertension therapeutic category, which works harmoniously to alleviate cardiovascular afflictions. Synonyms: Methyl 1-((2'-carboxaMidebiphenyl-4-yl) Methyl)-2-ethoxy-1H-benziMidazole-7-carboxylate; 1-((2'-carboxaMidebiphenyl-4-yl) Methyl)-2-ethoxy-1H-benziMidazole-7- carboxylic acid. Grades: > 95%. CAS No. 147404-76-0. Molecular formula: C25H23N3O4. Mole weight: 429.48. | |
| Azilsartan Impurity E | Azilsartan Impurity E is an impurity of Azilsartan, a drug used for treating hypertension, contributing to the advancement of cardiovascular medicine. Synonyms: Ethyl-3-Amino-2-[(2'-Cyanoiphenyl-4-yl) Methyl]-Amino Benzoate; Benzoic acid, 3-aMino-2-[[(2'-cyano[1,1'-biphenyl]-4-yl)Methyl]aMino]-, ethyl ester. Grades: > 95%. CAS No. 136285-69-3. Molecular formula: C23H21N3O2. Mole weight: 371.44. | |
| Azilsartan Impurity I | Azilsartan Impurity I is an impurity found in azilsartan, a medication primarily used for the therapy of hypertension. Synonyms: Methyl 1-((2'-cyanobiphenyl-4-yl) Methyl)-2H-benziMidazol-2-one-7-carboxylate); Methyl 3-((2'-cyanobiphenyl-4-yl)Methyl)-2-oxo-2,3-dihydro-1H-benzo[d]iMidazole-4-carboxylate. Grades: > 95%. CAS No. 139481-33-7. Molecular formula: C23H17N3O3. Mole weight: 383.41. | |
| Azilsartan Impurity J | Azilsartan Impurity J is an impurity of Azilsartan, a medication used for the therapy of high blood pressure. Synonyms: Methyl 2-oxo-3-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)Methyl)-2,3-dihydro-1H-benzo[d]iMidazole-4-carboxylate. Grades: > 95%. CAS No. 1403474-78-1. Molecular formula: C24H18N4O5. Mole weight: 442.43. | |
| Azilsartan Impurity L | Azilsartan Impurity L acts as a new angipotensin II receptor antagonist in mammals. Synonyms: 3-((2-carbamimidoylbiphenyl-4-yl)methyl)-2-ethoxy-3H-benzo[d]imidazole-4-carboxylic acid; 1-[[2'-(Aminoiminomethyl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic Acid. Grades: > 95%. CAS No. 1442400-65-8. Molecular formula: C24H22N4O3. Mole weight: 414.47. | |
| Azilsartan Impurity M | Azilsartan Impurity M is a superlative impurity of Azilsartan, an instrumental antihypertensive. Synonyms: 1-((2'-cyanobiphenyl-4-yl)Methyl)-2-ethoxy-1H-benziMidazole-7-carboxylic acid; 3-((2'-cyanobiphenyl-4-yl)Methyl)-2-ethoxy-3H-benzo[d]iMidazole-4-carboxylic acid; 1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid. Grades: > 95%. CAS No. 632322-61-3. Molecular formula: C24H19N3O3. Mole weight: 397.44. | |
| Azilsartan medoxomil | Azilsartan Medoxomil is a potent angiotensin II type 1 (AT1) receptor antagonist that inhibits the RAAS, with an IC50 of 2.6 nM. It exhibits more than 10,000-fold selectivity over AT2. Azilsartan Medoxomil can be used for the treatment of mild to moderate essential hypertension. Uses: The treatment of mild to moderate essential hypertension. Synonyms: TAK-491 Medoxomil; TAK491 Medoxomil; Edarbi; 863031-21-4; Azilsartan (medoxomil); TAK 491; UNII-LL0G25K7I2. Grades: >98%. CAS No. 863031-21-4. Molecular formula: C30H24N4O8. Mole weight: 568.53. | |
| Azilsartan medoxomil monopotassium | Azilsartan medoxomil monopotassium is an azilsartan prodrug and and an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM. It is used in the treatment of adults with essential hypertension. It inhibited cell proliferation at concentrations as low as 1 μmol/l in aortic endothelial cells in vitro. It has antiproliferative effects of azilsartan were also observed in cells lacking AT1 receptors. It was developed by Takeda Corporation. It has been listed. Uses: Azilsartan medoxomil monopotassium is used in the treatment of adults with essential hypertension. Synonyms: 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester potassium salt;Azilsartan MedoxoMil PotassiuM salt;Azilsartan kamedoxomil;TAK 491 monopotassium;Potassium,(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-3-[[4-[2- (5-oxo-1-oxa-2-aza-4-azanidacyclopent-2-en-3-yl) phenyl]phenyl]methyl]benzimidazole-4-carboxylate. Grades: >98%. CAS No. 863031-24-7. Molecular formula: C30H23KN4O8. Mole weight: 606.63. | |
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