BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Aspersitin | Aspersitin is an antibiotic produced by Aspergillus parasiticus. It has anti-gram-positive and negative bacteria activity. CAS No. 86996-89-6. Molecular formula: C14H21NO4. Mole weight: 267.32. |  |
| Asphalt | Synonyms: Asphalt; Bitumen. Grades: 95%. CAS No. 8052-42-4. | |
| Aspicilin | It is obtained from the lichens Aspicilia calcarea and A. gibbosa. Synonyms: (-)-Aspicillin; (5R,6S,7R,18S,E)-5,6,7-trihydroxy-18-methyloxacyclooctadec-3-en-2-one; (3E,5R,6S,7R,18S)-5,6,7-Trihydroxy-18-methyloxacyclooctadeca-3-en-2-one; Oxacyclooctadec-3-en-2-one, 5,6,7-trihydroxy-18-methyl-, (3E,5R,6S,7R,18S)-. Grades: 99%. CAS No. 52461-05-9. Molecular formula: C18H32O5. Mole weight: 328.44. | |
| Aspiculamycin | Aspiculamycin is a nucleoside peptide antibiotic produced by Streptomyces toyocaensis var. aspiculamyceticus. It has weak anti-Gram-positive bacteria, negative bacteria, mycobacteria and mycoplasma activity, and has the effect of repelling worms, nematodes and killing worms. Synonyms: Aspiculamycin; Quingfengmycin; Gougerotin. Molecular formula: C19H30O10N8. Mole weight: 530.49. | |
| Aspirin | Aspirin is a salicylate and irreversible COX1 and COX2 inhibitor. It can be used for the treatment of fever, rheumatism, nerve, muscle, joint pain, soft tissue inflammation and gout in animals. Synonyms: Acetylsalicylic acid; 1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12). Grades: 99.66%. CAS No. 50-78-2. Molecular formula: C9H8O4. Mole weight: 180.16. | |
| Asp-Leu | Alpha-Asp-Leu is a dipeptide formed from aspartic acid and leucine. Synonyms: H-ASP-LEU-OH; L-ASPARTIC ACID-L-LEUCINE; Asp-Leu-OH; L-Asp-L-Leu-OH; N-L-α-Aspartyl-L-leucine. Grades: ≥97% by HPLC. CAS No. 3062-14-4. Molecular formula: C10H18N2O5. Mole weight: 246.26. | |
| Aspochalasin D | Aspochalasin D is a potent inhibitor of mammalian tumor cell lines, first isolated from Aspergillus microcysticus. It has antibacterial activity against Gram-positive and Gram-negative bacteria at a concentration of 1 mg/ml. Aspochalasin D was found that it can strongly induce the formation of actin-containing rodlets in the cytoplasm of treated fibroblasts. Synonyms: 1H-Cycloundec(d)isoindole-1,15(2H)-dione, 3,3a,4,6a,9,10,11,12-octahydro-11,12-dihydroxy-4,5,8-trimethyl-3-(2-methylpropyl)-, (3S,3aR,4S,6aS,7E,11R,12S,13E,15aS)-. Grades: ≥95%. CAS No. 71968-02-0. Molecular formula: C24H35NO4. Mole weight: 401.54. | |
| Aspochalasine A | Aspochalasine is an antibiotic produced by Aspergillus microcysticus and an unidentified fungus FA2277. Aspochalasine A has anti-bacterial and fungal activity. Molecular formula: C24H33NO4. Mole weight: 399.52. | |
| Aspochalasine E | Aspochalasine is an antibiotic produced by Aspergillus microcysticus and an unidentified fungus FA2277. Molecular formula: C24H33NO3. Mole weight: 383.52. | |
| Aspochalasin M | Aspochalasin M is a fungal metabolite originally isolated from S. elegans. It can inhibit the growth of HL-60 cells (IC50 = 20 μM). Synonyms: Aspochalasin M; 1173040-34-0; (1S,5S,9Z,11S,14S,15R,16S)-5-hydroxy-9,13,14-trimethyl-16-(2-methylpropyl)-17-azatricyclo[9.7.0.01,15]octadeca-9,12-diene-2,6,18-trione; (3S,3aR,4S,6aS,7E,12S,15aS)-3,3a,4,6a,9,10,13,14-octahydro-12-hydroxy-4,5,8-trimethyl-3-(2-methylpropyl)-1H-cycloundec[d]isoindole-1,11,15(2H,12H)-trione. Grades: >95%. CAS No. 1173040-34-0. Molecular formula: C24H35NO4. Mole weight: 401.54. | |
| Aspochracin | Aspochracin is a cyclic tripeptide isolated from Aspergillus first. Aspochracin is toxic to caught worms (LD50 = 100 μg/g) and silkworms. Grades: >95% by HPLC. CAS No. 22029-09-0. Molecular formula: C23H36N4O4. Mole weight: 432.56. | |
| Aspoxicillin | Aspoxicillin is a semi-synthetic penicillin prepared from 6-aminopenicillanic acid (6-APA) or Amoxicillin. It has a broad antibacterial spectrum and has an effect on Pseudomonas aeruginosa. Synonyms: Aspoxicilina; Aspoxicilline; Aspoxicillinum. Grades: >98%. CAS No. 63358-49-6. Molecular formula: C21H27N5O7S. Mole weight: 493.53. | |
| Asp-Phe | A metabolite of Aspartame. Synonyms: L-Aspartyl-L-phenylalanine. Grades: >98%. CAS No. 13433-09-5. Molecular formula: C13H16N2O5. Mole weight: 280.28. | |
| Aspulvinone O | Aspulvinone O is a fungal metabolite originally isolated from P. variotti and has antioxidant and anticancer activities. It inhibits aspartate transaminase 1 (GOT1, Kd=3.32 μM) and is cytotoxic to PANC-1, AsPC-1, and SW1990 pancreatic cancer cells (IC50s = 20.54-26.8 μM). Aspulvinone O (2.5 and 5 mg/kg) reduces tumor growth in an SW1990 mouse xenograft model because it reduces the oxygen consumption rate (OCR) and induces apoptosis in SW1990 cells. Synonyms: 914071-54-8; 3-[2,4-dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-4-hydroxy-5-[[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]methylene]-2(5H)-furanone(5Z)-3-[2,4-dihydroxy-5-(3-methylbut-2-enyl)phenyl]-4-hydroxy-5-[[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]methylidene]furan-2-one; Aspulvinone OMEGxm0_000073. Grades: >98%. CAS No. 914071-54-8. Molecular formula: C27H28O6. Mole weight: 448.51. | |
| AST-1306 | AST-1306 functions as an irreversible inhibitor, most likely through covalent interaction with Cys797 and Cys805 in the catalytic domains of EGFR and ErbB2, respectively. It inactivated pathways downstream of these receptors and thereby inhibited the proliferation of a panel of cancer cell lines. It blocks phosphorylation of EGFR and also prevents downstream pathways. It also dose-dependently inhibits EGF-induced EGFR phosphorylation in the A549 cancer cell line. Synonyms: AST-1306; AST 1306; AST1306. Grades: >98%. CAS No. 897383-62-9. Molecular formula: C24H18ClFN4O2. Mole weight: 448.88. | |
| AST-1306 tosylate | AST-1306 is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases. Synonyms: AST-6; AST 6; AST6. Grades: >98%. CAS No. 1050500-29-2. Molecular formula: C24H18ClFN4O2,C7H8O3S. Mole weight: 621.08. | |
| AST 487 | AST487 is a Ret kinase inhibitor/FLT3 inhibitor, which displays high selectivity and potency toward FLT3 as a molecular target, and which could potentially be used to override drug resistance in AML. It induced a dose-dependent growth inhibition of xenografts of NIH3T3 cells expressing oncogenic RET, and of the MTC cell line TT in nude mice.It also inhibited calcitonin gene expression in vitro in TT cells, in part, through decreased gene transcription. Synonyms: NVP-AST 487; NVPAST487; AST 487; AST487; AST-487. Grades: >98%. CAS No. 630124-46-8. Molecular formula: C26H30F3N7O2. Mole weight: 529.56. | |
| Astacidin | Astacidin is an antimicrobial peptide produced by Procambarus clarkii (freshwater crayfish Pacifastacus leniusculus). It encodes a peptide of 43 amino acids, with a signal peptide of 23 amino acids. The mature peptide contains 20 amino acids, among which four are proline/arginine amino acids. The synthetic mature peptide has inhibitory effects on both Gram-positive and gram-negative bacteria and has the ability to bind bacterial cell wall components, including peptidoglycan, lipopolysaccharide and lipophoteicic acid. Synonyms: PcAst; Met-Arg-Leu-Leu-His-Leu-Leu-Leu-Ser-Val-Ala-Leu-Val-Ala-Leu-Met-Ala-Ala-Val-Pro-Ser-Gln-Ala-Ser-Asn-Gly-Tyr-Arg-Pro-Ala-Tyr-Arg-Pro-Ala-Tyr-Arg-Pro-Ser-Tyr-Arg-Pro-Gly-Lys. Grades: >98%. | |
| Astacidin 1 | Astacidin 1 is an antimicrobial peptide produced by Pacifastacus leniusculus (Procambarus clarkii, Red swamp freshwater crayfish). It exhibits antifungal activity against Candida albicans, Trichosporon beigelii, Malassezia furfur and Trichophyton rubrum. Synonyms: H-Phe-Lys-Val-Gln-Asn-Gln-His-Gly-Gln-Val-Val-Lys-Ile-Phe-His-His-OH; L-phenylalanyl-L-lysyl-L-valyl-L-glutaminyl-L-asparaginyl-L-glutaminyl-L-histidylglycyl-L-glutaminyl-L-valyl-L-valyl-L-lysyl-L-isoleucyl-L-phenylalanyl-L-histidyl-L-histidine. Grades: >97%. Molecular formula: C90H136N28O21. Mole weight: 1946.24. | |
| Astacidin 2 | Astacidin 2 is an antimicrobial peptide produced by Pacifastacus leniusculus (freshwater signal crayfish). It has a broad range of antibacterial activity against gram-positive and gram-negative bacteria. Synonyms: Arg-Pro-Arg-Pro-Asn-Tyr-Arg-Pro-Arg-Pro-Ile-Tyr-Arg-Pro-NH2. Grades: ≥95%. Molecular formula: C83H133N31O17. Mole weight: 1837.18. | |
| Astaxanthin | Astaxanthin is a carotenoid pigment found mostly in animal organisms, but also occurring in plants. It is thought to be the precursor of astacin. It is a potent lipid-soluble antioxidant. It has broad application prospects in health products, medicine, cosmetics, food additives and aquaculture. Uses: Ingredient of health care products. Synonyms: Ovoester; Astaxanthine; (3S,3'S)-Astaxanthin; All-trans-Astaxanthin; 3,3'-Dihydroxy-β,β-carotene-4,4'-dione; 3,3'-Dhydroxy-4,4'-diketo-β-carotene; trans-Astaxanthin; (3S,3'S)-all-trans-Astaxanthin; (6S,6'S)-3,3'-((1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaene-1,18-diyl)bis(6-hydroxy-2,4,4-trimethylcyclohex-2-enone). Grades: ≥97%. CAS No. 472-61-7. Molecular formula: C40H52O4. Mole weight: 596.84. | |
| Astechrome | Astechrome is an antibiotic produced by Aspergillus terreus (IFO 6123). It has weak antibacterial activity. Molecular formula: (C20H22N3O3)3Fe. Mole weight: 1113.09. | |
| Astepyrone | Astepyrone is an antibiotic produced by Aspergillus terreus (IFO 4100). It has anti-ulcer effect. CAS No. 86925-92-0. Molecular formula: C9H12O5. Mole weight: 200.19. | |
| Asterobactin | Asterobactin is a siderophore antibiotic produced by Nocardia asteroides IFM 0959. It has anti-tumor activity and inhibits HL-60 and HeLa cells at a concentration of 0.2-3.2 μg/mL, and Fe3+ can reduce its activity. Synonyms: Asterobactin A. CAS No. 482372-30-5. Molecular formula: C34H55N7O13. Mole weight: 769.84. | |
| Asterric acid | Asterric acid is an Endothelin (ET) binding inhibitor produced by Aspergillus sp. Synonyms: Dimethylosoic acid,TAN 1415A, WF 12880A. Grades: >98%. CAS No. 577-64-0. Molecular formula: C17H16O8. Mole weight: 348.30. | |
| Asterriquinol D dimethyl ether | Asterriquinol D dimethylether is a fungal metabolite first isolated from Aspergillus terreus as part of the asterriquinone complex. It is cytotoxic to NS-1 mouse myeloma cells with IC50 of 28 μg/ml. It has weak activity against tumor cells and the parasitic protozoan, Tritrichomonas foetus. Synonyms: 3,3'-(2,3,5,6-tetramethoxy-1,4-phenylene)bis-1H-indole. Grades: ≥95%. CAS No. 287117-66-2. Molecular formula: C26H24N2O4. Mole weight: 428.48. | |
| Asterriquinone CT1 | Asterriquinone CT1 is an asinquinone antibiotic produced by fungi. It has the effect of inhibiting serine protease in the blood mimicking pathway. Molecular formula: C32H26N2O4. Mole weight: 502.56. | |
| Asterriquinone CT2 | Asterriquinone CT2 is an asinquinone antibiotic produced by fungi. It has the effect of inhibiting serine protease in the blood mimicking pathway. Molecular formula: C32H28N2O4. Mole weight: 504.57. | |
| Asterriquinone SU5228 | Asterriquinone SU5228 is a quinone compounds containing indole produced by Aspergillus candidus. It has the effect of inhibiting the binding of Grb-2 adaptor (Adapter) to phosphorylated epidermal growth factor (EGF) receptor tyrosine kinase. Molecular formula: C27H22N2O4. Mole weight: 438.47. | |
| Asterriquinone SU5500 | Asterriquinone SU5500 is a quinone compounds containing indole produced by Aspergillus candidus. It has the effect of inhibiting the binding of Grb-2 adaptor (Adapter) to phosphorylated epidermal growth factor (EGF) receptor tyrosine kinase. Synonyms: 2,5-Bis[2-(3-methyl-2-butenyl)-1H-indole-3-yl]-3-acetoxy-6-hydroxy-1,4-benzoquinone. Molecular formula: C34H32N2O5. Mole weight: 548.64. | |
| Astexin-1 | Astexin-1 is an antimicrobial peptide produced by Asticcacaulis excentricus CB 48. It has antibacterial activity against gram-negative bacteria: Caulobacter crescentus CB15. Astexin-1 possesses a lasso structure, the isopeptide bond forming the macrolactam ring is between Gly1 and Asp9, an eight-residue loop above and a six-residue tail under the macrolactam ring are defined, with Glu17 above, Ser18 passing, and Arg19 under the ring. Grades: >98%. | |
| Asticolorin A | Asticolorin A is a mycotoxin produced by Aspergillus multicolor MRC 638. CAS No. 93376-70-6. Molecular formula: C33H30O7. Mole weight: 538.59. | |
| Asticolorin B | Asticolorin B is a mycotoxin produced by Aspergillus multicolor MRC 638. CAS No. 93376-71-7. Molecular formula: C33H28O7. Mole weight: 536.57. | |
| Asticolorin C | Asticolorin C is a mycotoxin produced by Aspergillus multicolor MRC 638. CAS No. 93395-44-9. Molecular formula: C33H28O9. Mole weight: 568.57. | |
| Astilbin | Cas No. 29838-67-3. | |
| Astragaloside | Astragaloside is extracted from roots of Astragalus membranaceus (Fisch.) Bunge. It is traditionally prescribed for the prevention and treatment of cerebrovascular diseases. Astragaloside is a natural compound used in cosmetics material. Synonyms: astragaloside; 17429-69-5; Isorhamnetin 3-gentiobioside; 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one4H-1-Benzopyran-4-one, 3-((6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-. Grades: >98%. CAS No. 17429-69-5. Molecular formula: C28H32O17. Mole weight: 640.5. | |
| Astragaloside A | Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases. Synonyms: Cyclosiversioside F (3b,6a,16b,24R)-20,24-Epoxy-16,26-dihydroxy-3-(b-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl b-D-glucopyranoside. Grades: >98%. CAS No. 83207-58-3. Molecular formula: C41H68O14. Mole weight: 784.97. | |
| Astragaloside I | Astragaloside I is extracted from roots of Astragalus membranaceus (Fisch.) Bunge. It has anti-gastric effect. It has been shown to increase gastric pH without changing gastric volume or acid output. Uses: Astragaloside i has cardioprotective effects as well as causing improvement in cognitive function. it has anti-gastric effect and could increase gastric ph without changing gastric volume or acid output. Synonyms: (3β,6α,16β,20R,24S)-3-[(2,3-Di-O-acetyl-β-D-xylopyranosyl)oxy]-20,24-epoxy-16,25-dihydroxy-9,19-cyclolanostan-6-yl β-D-glucopyranoside; Astrasieversianin IV; Cyclosieversioside B. Grades: >98%. CAS No. 84680-75-1. Molecular formula: C45H72O16. Mole weight: 869.04. | |
| Astragalus polysaccharide | Astragalus polysaccharide is one kind of biological macromolecule extracted from Astragalus. It has antiviral activities. Uses: Astragalus polysaccharide has antiviral activities. Synonyms: 2-(Chloromethyl)-4-(4-nitrophenyl)thiazole;Thiazole,2-(chloromethyl)-4-(4-nitrophenyl)-;Astragalus Polysacharin;Astragalus Root Extract;2-(Chloromethyl)-4-(4-nitrophenyl)-1,3-thiazole. Grades: >98 %. CAS No. 89250-26-0. Molecular formula: C10H7ClN2O2S. Mole weight: 254.69. | |
| Astressin | Astressin is a novel potent corticotropin releasing factor (CRF) antagonist. Astressin may be a useful tool to explore functional CRF-dependent physiological pathways in specific brain nuclei. Uses: Neuroprotective agents. Synonyms: (D-Phe12,Nle21·38,Glu30,Lys33)-CRF (12-41) (human, rat); H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Glu(1)-Ala-His-Lys(1)-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2. Grades: ≥95%. CAS No. 170809-51-5. Molecular formula: C161H269N49O42. Mole weight: 3563.16. | |
| Astressin 2B | Astressin 2B is a selective and potent corticotropin-releasing factor receptor 2 (CRF2) antagonist with IC50 values of > 500 nM and 1.3 for CRF1 and CRF2 respectively. It antagonizes CRF2-mediated inhibition of gastric emptying. Synonyms: Cyclo(31-34)[D-Phe11, His12, C(α)MeLeu13, 39, Nle17, Glu31, Lys34]Ac-Svg(8-40). Grades: >98%. CAS No. 681260-70-8. Molecular formula: C183H307N49O53. Mole weight: 4041.69. | |
| ASTX-660 2HCl | The dihydrochloride salt form of ASTX-660 which is found to be an IAP as well as XIAP inhitor that could be significant in the studies of lymphoma and solid tumours. It is still under Phase I/II trial. Synonyms: ASTX660 2HCl; ASTX-660 2HCl; ASTX 660 2HCl; 1-(6-(4-fluorobenzyl)-3,3-dimethylindolin-1-yl)-2-((2R,5R)-5-methyl-2-(((R)-3-methylmorpholino)methyl)piperazin-1-yl)ethan-1-one dihydrochloride. Grades: 98%. CAS No. 1605316-16-2. Molecular formula: C30H43Cl2FN4O2. Mole weight: 581.59. | |
| ASTX-660 Freebase | ASTX-660 is found to be an IAP as well as XIAP inhitor that could be significant in the studies of lymphoma and solid tumours. It is still under Phase I/II trial. Synonyms: ASTX660; ASTX-660; ASTX 660; 1-(6-(4-fluorobenzyl)-3,3-dimethylindolin-1-yl)-2-((2R,5R)-5-methyl-2-(((R)-3-methylmorpholino)methyl)piperazin-1-yl)ethan-1-one. Grades: 98%. CAS No. 1605584-14-2. Molecular formula: C30H41FN4O2. Mole weight: 508.59. | |
| Asukamycin | Asukamycin, a manumycin-type metabolite, is isolated from Streptomyces nodosus subsp. asukaensis. It exhibits antibiotic properties and inhibits the growth of various tumor cell lines. Synonyms: asukamycin A1; Manumycin F; 2,4,6-Heptatrienamide, 7-cyclohexyl-N-[(1S,5S,6R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-7-oxo-1,3,5-heptatrien-1-yl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-, (2E,4E,6E)-. Grades: >98%. CAS No. 61116-33-4. Molecular formula: C31H34N2O7. Mole weight: 546.61. | |
| Asunaprevir | Asunaprevir is a potent hepatitis C virus (HCV) non-structural protein protease inhibitor currently in Phase III clinical trials for the treatment of HCV infection. Uses: Protease inhibitors. Synonyms: BMS-650032; BMS 650032; BMS650032; Asunaprevir. brand name: Sunvepra. Grades: >98%. CAS No. 630420-16-5. Molecular formula: C35H46ClN5O9S. Mole weight: 748.29. | |
| Asymmetric Doubler (Lev) Phosphoramidite | Asymmetric Doubler (Lev) Phosphoramidite is a critical reagent used in the synthesis of nucleic acids with high efficiency and precision. It serves as a catalyst for the asymmetric doubling of chiral phosphoramidites, making it an essential tool for the production of oligonucleotides used in diagnostics and therapeutics for various diseases including cancer, viral infections and genetic disorders. Synonyms: 1-[5-(4,4'-dimethoxytrityloxy)pentylamido]-3-[5-levulinyloxypentylamido]-propyl-2-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. Molecular formula: C48H67N4O10P. Mole weight: 891.04. | |
| Asymmetric Methylene Conjugated Emtricitabine Dimer | Asymmetric Methylene Conjugated Emtricitabine Dimer is an impurity of Emtricitabine, which is a nucleoside reverse transcriptase inhibitor for the treatment of HIV infection in adults and children. Synonyms: 4-Amino-5-fluoro-1-[(2R,5S)-2-[[[[5-fluoro-1,2-dihydro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2-oxo-4-pyrimidinyl]amino]methoxy]methyl]-1,3-oxathiolan-5-yl]-2(1H)-Pyrimidinone; 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-[(2R,5S)-2-[[[[5-fluoro-1,2-dihydro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2-oxo-4-pyrimidinyl]amino]methoxy]methyl]-1,3-oxathiolan-5-yl]-; Emtricitabine FT3. CAS No. 1962114-96-0. Molecular formula: C17H20F2N6O6S2. Mole weight: 506.50. | |
| Aszonalenin | Aszonalenin is a nitrogen-containing heterocyclic antibiotic produced by Aspergillus zonatus. It can cause abnormal second division of sea urchin embryo. CAS No. 81797-27-5. Molecular formula: C23H23N3O2. Mole weight: 373.45. | |
| Aszonapyrone A | Aszonapyrone A is a lactone antibiotic produced by Aspergillus zonatus, which has anti-Staphylococcus aureus activity. CAS No. 83103-08-6. Molecular formula: C28H40O5. Mole weight: 456.61. | |
| AT101 | AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM. Synonyms: AT-101; AT 101; AT101. Grades: >98%. CAS No. 90141-22-3. Molecular formula: C30H30O8·C2H4O2. Mole weight: 578.6. | |
| AT-101 acetic acid | AT101 acetic acid is orally bioavailable solvate of R-(-)-enantiomer of gossypol with potential antineoplastic activity. It is used as the treatment of non Hodgkin's lymphoma, prostate cancer, and non small cell cancer. It binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM. It induces apoptosis in vitro through activation of caspase-9. It delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo. It was developed by Ascenta and in clinical phase 2. Uses: At101 acetic acid is used as the treatment of non hodgkin's lymphoma, prostate cancer, and non small cell cancer. Synonyms: AT-101 acetic acid; AT 101 acetic acid; AT101 acetic acid; (R)-(-)-Gossypol acetic acid;(-)-Gossypol acetic acid;(R)-Gossypol acetic acid;Acetic acid 7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehyde. Grades: >98 %. CAS No. 866541-93-7. Molecular formula: C32H34O10. Mole weight: 578.61. | |
| AT13148 | AT13148 is an orally available multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity. It can block phosphorylation of AKT, p70S6K, PKA, ROCK and SGK substrates, and induce apoptosis in cancer cells. Synonyms: AT-13148; (1S)-2-amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)phenyl]ethanol. Grades: >98%. CAS No. 1056901-62-2. Molecular formula: C17H16ClN3O. Mole weight: 313.78. | |
| AT-1459 | AT-1459 is a novel, direct thrombin inhibitor with antithrombotic efficacy (Ki = 4.9 nM). Uses: Thrombin inhibitor. Synonyms: AT-1459; AT 1459; AT1459; UNII-JWP323ABVS; Butanoic acid, 4-[[(3S)?-1-[2-[(2S)?-2-[2-[6-(aminoiminomethyl)?-1-ethyl-1H-indol-2-yl]?ethyl]?-1-pyrrolidinyl]?-2-oxoethyl]?hexahydro-2-oxo-1H-azepin-3-yl]?amino]?-. Grades: ≥95%. CAS No. 294658-50-7. Molecular formula: C29H42N6O4. Mole weight: 538.32. | |
| AT 1902 | AT 1902 is a bio-active compound, but no detailed information has been published yet. Synonyms: AT 1902; AT-1902; AT1902; BRN 1714871; Nitriloacetic acid trihydride; NSC 351359; Nitrazine;Nitrazine;N,N-Bis(2-hydrazino-2-oxoethyl)glycine hydrazide;Glycine, N,N-bis(2-hydrazino-2-oxoethyl)-, hydrazide (9CI). Grades: 98%. CAS No. 80155-82-4. Molecular formula: C6H15N7O3. Mole weight: 233.23. | |
| AT 2433 A1 | AT 2433 A1 is an anti-tumor antibiotic produced by Actinomadura melliaura. It has activity against gram-positive bacteria. It can prolong the survival period of transplanted leukemia P388 mice. Synonyms: AT2433-A1; 6-Methyl-11-chloro-12-[6-O-[4-(methylamino)-2,4-dideoxy-alpha-L-threo-pentopyranosyl]-4-O-methyl-beta-D-glucopyranosyl]-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione. Grades: >98%. CAS No. 102644-20-2. Molecular formula: C34H35ClN4O9. Mole weight: 679.11. | |
| AT 2433 A2 | AT 2433 A2 is an anti-tumor antibiotic produced by Actinomadura melliaura. It has activity against gram-positive bacteria. Synonyms: AT 2433-A2; AT2433-A2. Grades: >98%. CAS No. 102644-19-9. Molecular formula: C33H33ClN4O9. Mole weight: 665.09. | |
| AT 2433 B1 | AT 2433 B1 is an anti-tumor antibiotic produced by Actinomadura melliaura. It has activity against gram-positive bacteria. It can prolong the survival period of transplanted leukemia P388 mice. Synonyms: AT2433-B1. Grades: >98%. CAS No. 102622-96-8. Molecular formula: C34H36N4O9. Mole weight: 644.67. | |
| AT 2433 B2 | AT 2433 B2 is an anti-tumor antibiotic produced by Actinomadura melliaura. It has activity against gram-positive bacteria. Synonyms: AT2433-B2; 5H-Indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione, 12-(6-O-(4-amino-2,4-dideoxypentopyranosyl)-4-O-methylhexopyranosyl)-12,13-dihydor-6-methyl-. Grades: >98%. CAS No. 102622-95-7. Molecular formula: C33H34N4O9. Mole weight: 630.64. | |
| AT-265 | AT-265 is a nucleoside antibiotic produced by Streptomyces rishiensis. It has anti-gram-positive and negative bacteria activity. Synonyms: 5'-Sulfamoyl-2-chloroadenosine; 2-chloro-5'-o-sulfamoyladenosine; Antibiotic AT 265. Grades: >98%. CAS No. 66522-52-9. Molecular formula: C10H13ClN6O6S. Mole weight: 380.77. | |
| AT-308 | AT-308 is a synthetic bio-active chemical. Uses: A synthetic bio-active chemical. Synonyms: AT-308; AT 308; AT308; AC1L4RQW; AC1Q642X; Ethyl 2-methyl-2-{4-[5-(pyridin-3-yl)-1,2,4-oxadiazol-3-yl]phenoxy}propanoate. Grades: ≥98%. CAS No. 40915-84-2. Molecular formula: C19H19N3O4. Mole weight: 353.38. | |
| AT-406 | AT-406 is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3 (with Ki of 66.4 nM), cIAP1-BIR3(with Ki of 1.9 nM) and cIAP2-BIR3 (with Ki of 5.1 nM), respectively. Synonyms: AT406; AT 406; SM-406; SM 406; SM406; ARRY-334543; ARRY 334543; ARRY334543. Grades: >98%. CAS No. 1071992-99-8. Molecular formula: C32H43N5O4. Mole weight: 561.71. | |
| AT 4930 | AT-4930 is a bio-active molecular, but detailed information has not been published yet. Synonyms: AT 4930; AT4930; AT-4930; 5-amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-Quinolinecarboxylic acid. Grades: 98%. CAS No. 123016-40-0. Molecular formula: C19H23FN4O. Mole weight: 374.41. | |
| AT-584 | AT-584, an azoniatricyclo compound, could have potential biological activity in pharmaceutical studies. Synonyms: AT 584; AT-584; AT584; Hexamethylenetetramine salt of p-(bis(2-chloroethyl)amino)-alpha-bromoacetophenone; 1-(p-(Bis(2-chloroethyl)amino)phenacyl)-3,5,7-triaza-1-azoniaadamantane bromide; 1-(2-(4-(Bis(2-chloroethyl)amino)phenyl)-2-oxoethyl)-3,5,7-triaza-1-azonia. Grades: 98%. CAS No. 16810-17-6. Molecular formula: C18H26BrCl2N5O. Mole weight: 479.24. | |
| AT-61 | AT-61 is a nonnucleoside analogue inhibitors of hepatitis B virus (HBV) replication. Uses: Inhibitors of hepatitis b virus (hbv) replication. Synonyms: AT 61; AT-61; AT61; N-(1-(Bromophenylmethylene)-2-oxo-2-piperidylethyl)benzamide; Benzamide, N-(2-chloro-2-phenyl-1-(1-piperidinylcarbonyl)ethenyl)-; N-[1-(Bromophenylmethylene)-2-oxo-2-piperidylethyl]benzamide. Grades: ≥98%. CAS No. 300669-68-5. Molecular formula: C21H21ClN2O2. Mole weight: 368.86. | |
| AT-7519 | AT-7519 is an orally bioavailable small molecule CDK inhibitor with potential antineoplastic activity. AT7519M selectively binds to and inhibits cyclin dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation. Synonyms: AT-7519, AT7519, AT 7519, AT-7519 free base. Grades: 0.98. CAS No. 844442-38-2. Molecular formula: C16H17Cl2N5O2. Mole weight: 382.24. | |
| AT7519 HCl | AT-7519 is an orally bioavailable small molecule CDK inhibitor with potential antineoplastic activity. AT7519M selectively binds to and inhibits cyclin dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation. Synonyms: AT7519 HCl; AT 7519 HCl; AT-7519 HCl. CAS No. 902135-91-5. Molecular formula: C16H18Cl3N5O2. Mole weight: 418.71. | |
| AT 7519 mesylate | AT 7519 mesylate is a small-molecule inhibitor of CDK including CDK 1, 2, 4, 5, 6, and 9 in vitro and it induces apoptosis in multiple myeloma via GSK-3β activation and RNA polymerase II inhibition. Synonyms: AT 7519 mesylate; AT7519 mesylate; AT-7519 mesylate; AT-7519M; AT 7519M, AT7519M; 4-[(2,6-dichlorobenzoyl)amino]-N-piperidin-4-yl-1H-pyrazole-5-carboxamide methanesulfonic acid. Grades: 99%. CAS No. 902135-89-1. Molecular formula: C16H17Cl2N5O2.CH4O3S. Mole weight: 478.35. | |
| AT7867 | AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the AGC kinase family. Synonyms: AMG-706; AMG 706; AMG706; AT7867; AT 7867; AT-7867. Grades: >98%. CAS No. 857531-00-1. Molecular formula: C20H20ClN3. Mole weight: 337.85. | |
| AT7867 dihydrochloride | AT7867 also inhibits structurally related AGC kinases p70S6K and PKA with IC50 of 20 nM and 85 nM, respectively. AT7867 shows ATP-competitive activity to Akt2 with Ki of 18 nM. AT7867 exhibits antiproliferation in cell lines with PTEN or PIK3CA mutations and shows great potent to MES-SA, MDA-MB-468, MCF-7, HCT116 and HT29 with IC50 of 0.94 μM, 2.26 μM, 1.86 μM, 1.76 μM and 3.04 μM, respectively. AT7867 also suppresses the cell growth of U87MG, PC-3 and DU145 cells with IC50 of 8.22 μM, 10.37 μM and 11.86 μM, respectively. AT7867 suppresses Akt activity by inhibiting phosphorylation of GSK-3β in human tumor cells with IC50 of 2-4 μM. AT7867 also induces the phosphorylation of the following Akt direct substrates including proapoptotic transcription factors FKHR (FoxO1a), FKHRL1 (FoxO3a) and the downstream target S6RP in U87MG cells. AT7867 shows bioavailability of 44% in mice by p.o. route. AT7867 could increase the cleaved PARP in MES-SA xenografts at 20 mg/kg i.p. or 90 mg/kg p.o. AT7867 significantly inhibits the tumor growth in MES-SA xenografts or U87MG xenografts with T/C of 0.37 and 0.51, respectively. Synonyms: AT-7867 dihydrochloride; AT 7867 dihydrochloride. Grades: >98%. CAS No. 1431697-86-7. Molecular formula: C20H22Cl3N3. Mole weight: 410.77. | |
| AT9283 | AT-9283 is a broad spectrum kinase inhibitor that potently inhibits Aurora A, Aurora B, JAK2, JAK3, and c-ABL (IC50= 3, 3, 1.2, 1.1, and 4 nM, respectively). It also potently (IC50 = <1 μM) inhibits serine/threonine kinases as well as receptor and non-receptor tyrosine kinases. Synonyms: AT9283; AT 9283; AT-9283. Grades:>98%. CAS No. 896466-04-9. Molecular formula: C19H23N7O2. Mole weight: 381.43. | |
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