BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Arphamenine A | Arphamenine A is an enzyme inhibitor produced by Chromobacteriuin violaceum HMG361-CF4. It can inhibit the activity of aminopeptidase B, and can inhibit sarcoma 180 and IMC cancer. Synonyms: Benzenepropanoic acid, α-[(3S)-3-amino-6-[(aminoiminomethyl)amino]-2-oxohexyl]-, (αR)-; (αR)-α-[(3S)-3-Amino-6-[(aminoiminomethyl)amino]-2-oxohexyl]benzenepropanoic acid; Benzenepropanoic acid, α-[3-amino-6-[(aminoiminomethyl)amino]-2-oxohexyl]-, [S-(R*,S*)]-; Arphamenin A. Grades: ≥95%. CAS No. 96551-81-4. Molecular formula: C16H24N4O3. Mole weight: 320.39. |  |
| Arphamenine B | Arphamenine B is a specific inhibitor of aminopeptidase B, which is first isolated from bacteria. Arphamenine B shares the same properties as the aminopeptidase inhibitors bestatin and amastatin, both of which enhance the immune response. Synonyms: Benzenepropanoic acid, α-[(3S)-3-amino-6-[(aminoiminomethyl)amino]-2-oxohexyl]-4-hydroxy-, (αR)-; (αR)-α-[(3S)-3-Amino-6-[(aminoiminomethyl)amino]-2-oxohexyl]-4-hydroxybenzenepropanoic acid; Benzenepropanoic acid, α-[3-amino-6-[(aminoiminomethyl)amino]-2-oxohexyl]-4-hydroxy-, [S-(R*,S*)]-; Arphamenin B. Grades: 95%. CAS No. 103900-19-2. Molecular formula: C16H24N4O4. Mole weight: 336.39. | |
| ARQ-087 | ARQ-087, also known as Derazantinib, is an oral fibroblast growth factor receptor (FGFR) inhibitor with antitumor property. FGFR plays a role in the regulation of key cellular behaviors including proliferation, cell differentiation and so on. FGFR dysregulation is considered as a driver in multiple cancers. ARQ 087 binds to FGFR and effectively inhibits the activation of FGFR thus can suppress tumorigenesis and tumor growth. Synonyms: ARQ 087; ARQ087; ARQ-087; Derazantinib; (6R)-6-(2-fluorophenyl)-N-[3-[2-(2-methoxyethylamino)ethyl]phenyl]-5,6-dihydrobenzo[h]quinazolin-2-amine. Grades: ≥98%. CAS No. 1234356-69-4. Molecular formula: C29H29FN4O. Mole weight: 468.576. | |
| ARQ-092 | ARQ-092, also called as Miransertib, is an oral activie, potent and selective AKT inhibitor with IC50=5.0 nM against AKT1, 4.5 nM against AKT2 and 16 nM against AKT3. ARQ-092 inhibits the PI3K/AKT signaling pathway due to inhibition of the activity of AKT in a non-ATP competitive manner. This may lead to the reduction in tumor cell proliferation and the induction of tumor cell apoptosis. Synonyms: 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine; ARQ092; ARQ-092; ARQ 092; Miransertib. Grades: >98%. CAS No. 1313881-70-7. Molecular formula: C27H24N6. Mole weight: 432.53. | |
| ARQ 531 | ARQ-531 is a potent and orally active BTK inhibitor with potential antineoplastic activity. ARQ 531 is a reversible non-covalent inhibitor of Bruton's Tyrosine Kinase (BTK), with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively. It also has a distinct kinase selectivity profile with strong inhibitory activity against several key oncogenic drivers from TEC, Trk and Src family kinases. In GCB-DLBCL cell lines (SUDHL-4 and DOHH-2), ARQ 531 potently suppressed expression of anti-apoptotic c-Myc and BCL6 oncoproteins in a dose-dependent fashion, and concomitantly induced apoptotic cleavage of PARP protein. Synonyms: ARQ-531. Grades: ≥98%. CAS No. 2095393-15-8. Molecular formula: C25H23ClN4O4. Mole weight: 478.93. | |
| ARQ 736 | ARQ 736 is a potent and selective BRAF inhibitor. ARQ 736 is selectively potent in killing cancer cell lines harboring at least one mutated BRAF allele. BRAF mutations were detected in over 60% of melanomas and may account for a significant proportion of colon cancer patients whose tumors are resistant to anti-EGFR therapy. Synonyms: ARQ 736; ARQ736; ARQ-736. CAS No. 1228237-47-5. Molecular formula: C25H25N8Na2O8PS. Mole weight: 630.569. | |
| ARRY-380 | ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold more selective for HER2 versus EGFR. Synonyms: ARRY-380; ARRY 380; ARRY380. Grades: >98%. CAS No. 937265-83-3. Molecular formula: C29H27N7O4S. Mole weight: 569.63. | |
| ARRY-520 R enantiomer | ARRY-520 R enantiomer is the R form of ARRY-520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor. ARRY-520 had low nanomolar antiproliferative activity in tumor cell lines and specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Synonyms: ARRY-520 R enantiomer; ARRY 520 R enantiomer; ARRY520 R enantiomer; 1,3,4-Thiadiazole-3(2H)-carboxamide, 2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-, (2R)-. Grades: >98%. CAS No. 885060-08-2. Molecular formula: C20H22F2N4O2S. Mole weight: 420.48. | |
| ARS-1323 | ARS-1323 is an inhibitor of mutant K-ras G12C. Synonyms: ARS-1323; ARS 1323; ARS1323; 6-[6-chloro-8-fluoro-4-(4-prop-2-enoylpiperazin-1-yl)-1H-quinazolin-7-ylidene]-5-fluorocyclohexa-2,4-dien-1-one. CAS No. 1698024-73-5. Molecular formula: C21H17ClF2N4O2. Mole weight: 430.84. | |
| ARS-1620 | ARS-1620 is a potent and selective KRAS-G12C inhibitor. ARS-1620 achieves rapid and sustained in vivo target occupancy to induce tumor regression. Synonyms: ARS-1620; ARS 1620; ARS1620; BCP29125; BCP 29125; BCP-29125; 6-[6-chloro-8-fluoro-4-(4-prop-2-enoylpiperazin-1-yl)-1H-quinazolin-7-ylidene]-5-fluorocyclohexa-2,4-dien-1-one sulfane. CAS No. 1698055-85-4. Molecular formula: C21H17ClF2N4O2. Mole weight: 430.84. | |
| ARS-1630 | ARS-1630 is the R-enantiomer of ARS-1620. It is an inhibitor of mutant K-ras G12C. Synonyms: ARS-1630; ARS 1630; ARS1630; (R)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one. CAS No. 1698055-86-5. Molecular formula: C21H17ClF2N4O2. Mole weight: 430.84. | |
| ARS-853 | ARS-853 is a selective, allele-specific inhibitor of KRAS, which blocks KRAS signaling and suppresses tumor growth (IC50 = 2.5 μM). Synonyms: ARS-853; ARS853; ARS 853; SCHEMBL16117872; AKOS032944976; CS-6065; CS 6065; CS6065; 1-[3-[4-[2-[4-chloro-2-hydroxy-5- (1-methylcyclopropyl) anilino]acetyl]piperazin-1-yl]azetidin-1-yl]prop-2-en-1-one. Grades: 99.02 %. CAS No. 1629268-00-3. Molecular formula: C22H29ClN4O3. Mole weight: 432.94. | |
| ARTC1 | ARTC1 is a regulator of GRP78/BiP in GRP78-mediated ER stress responses. | |
| Arteether | Artemotil is a fast-acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria cases. It is a semi-synthetic derivative of artemisinin, a natural product of the Chinese plant Artemisia annua. It is currently only used as a second line drug in severe cases of malaria. Uses: Amebicides. Synonyms: (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-Ethoxy-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]-2-benzopyran; 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, 10-ethoxydecahydro-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,10S,12R,12aR)-; (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-Ethoxydecahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin; 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, 10-ethoxydecahydro-3,6,9-trimethyl-, [3R-(3α, 5aβ, 6β, 8aβ, 9α, 10α, 12β, 12aR*)]-; (+)-Arteether; Artemotil; Dihydroartemisinin ethyl ether; Dihydroqinghaosu ethyl ether; NSC 665971; SM 227; β-Arteether; β-Dihydroartemisinin ethyl ether. Grades: ≥95%. CAS No. 75887-54-6. Molecular formula: C17H28O5. Mole weight: 312.41. | |
| Artemether | Artemether is an antimalarial for the treatment of multiple drug-resistant strains of Plasmodium falciparum malaria. Synonyms: Dihydroartemisinin Methyl Ether; Falcidol; Gvither; Larither; Malartem; SM 224; β-Artemether; β-Dihydroartemisinin Methyl Ether; (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin. Grades: >99%. CAS No. 71963-77-4. Molecular formula: C16H26O5. Mole weight: 298.37. | |
| Artemether Impurity C | An impurity of Artemether. Artemether is an antimalarial for the treatment of multiple drug-resistant strains of Plasmodium falciparum malaria. Synonyms: Artemether Tetrahydrofuran Acetate; (3aS,4R,6aS,7R,8S,10R,10aR)-Octahydro-8-methoxy-4,7-dimethyl-2H,10H-furo[3,2-i][2]benzopyran-10-ol 10-Acetate. Grades: > 95%. CAS No. 181528-64-3. Molecular formula: C16H26O5. Mole weight: 298.38. | |
| Artemisinic acid | Artemisinic acid, a sesquiterpene isolated from Artemisia annua L, has a variety of pharmacological activities, such as antimalarial, antitumor, antipyretic, antibacterial, allelopathy, and anti-lipogenesis. Uses: Antibacterial. Synonyms: 2-((1R,4R,4aS,8aS)-4,7-Dimethyldecahydronaphthalen-1-yl)acrylic Acid; [1R-(1α, 4β, 4aβ, 8aβ)]-1, 2, 3, 4, 4a, 5, 6, 8a-Octahydro-4, 7-dimethyl-α-methylene-1-naphthaleneacetic Acid; (1R,4R,4aS,8aR)-1,2,3,4,4a,5,6,8a-Octahydro-4,7-dimethyl-α-methylene-1-naphthaleneacetic Acid; Arteannuic Acid; Arteannuinic Acid; Artemisic Acid; Artemisininic Acid; Qing Hao Acid; Qing Hau Acid. Grades: >98%. CAS No. 80286-58-4. Molecular formula: C15H22O2. Mole weight: 234.33. | |
| Artemisinin | Artemisinin is a natural product originally isolated from plants of the genus Artemisia. It effectively kills malarial parasites of the genus Plasmodium. It is usually used in combination therapy for the treatment of malaria. Artemisinin is also used against a wide range of trematodes, including Schistosoma. Artemisinin is an inhibitor of human NOS2 (iNOS) with anticancer activity. Synonyms: (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epox12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one; Artemisine; Arteannuin; Huanghuahaosu; QHS; Qinghaosu; (+)-Artemisinin. Grades: 98% by HPLC. CAS No. 63968-64-9. Molecular formula: C15H22O5. Mole weight: 282.33. | |
| Artemisinin Impurity B | A metabolite of Artemisinin. Synonyms: 9-epi Artemisinin. Grades: > 95%. CAS No. 113472-97-2. Molecular formula: C15H22O5. Mole weight: 282.34. | |
| Artemisitene (Methyl Artemisinin) | A derivative of Artemether. Artemether is an antimalarial for the treatment of multiple drug-resistant strains of Plasmodium falciparum malaria. Synonyms: (3R,5aS,6R,8aS,12S,12aR)-Octahydro-3,6-dimethyl-9-methylene-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one; (+)-Artemisitene Dehydroqinghaosu. Grades: > 95%. CAS No. 101020-89-7. Molecular formula: C15H20O5. Mole weight: 280.32. | |
| Arthoniaic acid | Arthoniaic acid is a carbonyl compound. Synonyms: 4-Carboxy-3-methoxy-5-(2-oxoheptyl)phenyl 2,4-dihydroxy-6-(2-oxoheptyl)benzoate; Arthonia acid. CAS No. 25556-24-5. Molecular formula: C29H36O9. Mole weight: 528.59. | |
| Arthothelin | Arthothelin is a xanthene compound. Synonyms: Xanthen-9-one, 2,4,5-trichloro-1,3,6-trihydroxy-8-methyl- (8CI); 2,4,5-Trichloro-1,3,6-trihydroxy-8-methyl-9H-xanthen-9-one. CAS No. 20716-96-5. Molecular formula: C14H7Cl3O5. Mole weight: 361.56. | |
| Arthrobacter stabilis exopolysaccharide | | |
| Arthrobacter viscosus exopolysaccharide | | |
| Articaine Hydrochloride | Articaine is a dental amide-type local anesthetic. It is the most widely used local anesthetic in a number of European countries and is available in many countries around the world. Synonyms: Articaine HCl; Articaine Hydrochloride; Carticaine HCl; Hoe-40045; Hoe-045; Carticaine Hydrochloride; Ultracaine. Grades: >98%. CAS No. 23964-57-0. Molecular formula: C13H20N2O3S.HCl. Mole weight: 320.84. | |
| Articaine Impurity A | A metabolite of Articaine. Synonyms: Acetamidoarticaine HCl. Grades: > 95%. CAS No. 1712677-79-6. Molecular formula: C12H18N2O3S HCl. Mole weight: 270.35 36.46. | |
| Articaine Impurity B | A metabolite of Articaine. Synonyms: Articaine Acid HCl. Grades: > 95%. CAS No. 114176-52-2. Molecular formula: C12H18N2O3S HCl. Mole weight: 270.35 36.46. | |
| Articaine Impurity E | A metabolite of Articaine. Synonyms: Isopropylarticaine HCl. Grades: > 95%. CAS No. 1796888-45-3. Molecular formula: C13H20N2O3S HCl. Mole weight: 284.38 36.46. | |
| Articaine Impurity G | A metabolite of Articaine. Synonyms: Butylarticaine HCl. Grades: > 95%. CAS No. 23964-59-2. Molecular formula: C14H22N2O3S HCl. Mole weight: 298.41 36.46. | |
| Articaine Impurity I | A metabolite of Articaine. Synonyms: Methyl 3-Amino-4-Methylthiophene-2-Carboxylate. Grades: > 95%. CAS No. 85006-31-1. Molecular formula: C7H9NO2S. Mole weight: 171.22. | |
| Arugomycin | Arugomycin is an onion ring antibiotic produced by Streptomyces violochromogenes 1098-AV2. It has anti-Gram-positive bacteria activity, and its anti-Ehrlich ascites cancer activity is similar to that of Acalamycin, but lower than that of Doxorubicin. Synonyms: 2,6-Epoxy-2H-naphthaceno(1,2-b)oxocin, arugomycin deriv. CAS No. 88465-80-9. Molecular formula: C80H112N2O37. Mole weight: 1693.73. | |
| Arugosin C | Arugosin C is an anthraquinone derivative produced by the strain of Aspergillus found in the Red Sea. Synonyms: Arugosin C; 50875-10-0; CHEBI:68860; [1]Benzopyrano[4,5-bc][1]benzoxepin-7(2H)-one,1,12a-dihydro-6,8-dihydroxy-1-(1-hydroxy- 1-methylethyl)-4-methyl-9-(3-methyl-2- butenyl)-; FD39J64RWK; UNII-FD39J64RWK; 6,8-dihydroxy-1-(2-hydroxypropan-2-yl)-4-methyl-9-(3-methylbut-2-en-1-yl)-1,12a-dihydrochromeno[4,5-bc][1]benzoxepin-7(2h)-one; MLS004257379; CHEMBL3092848; SMR003082511; Q15410264; 1,12a-Dihydro-6,8-dihydroxy-1-(1-hydroxy-1-methylethyl)-4-methyl-9-(3-methylbut-2-enyl)(1)benzopy rano(4,5-bc)(1)benzoxepin-7(2H)-one; 1,12a-Dihydro-6,8-dihydroxy-1-(1-hydroxy-1-methylethyl)-4-methyl-9-(3-methylbut-2-enyl)(1)benzopyrano(4,5-bc)(1)benzoxepin-7(2H)-one. CAS No. 50875-10-0. Molecular formula: C25H28O6. Mole weight: 424.48. | |
| ARV-771 | ARV-771 is a potent BET bromodomain PROTAC® Degrader based on von Hippel-Lindau (VHL) E3 ligase, consisting of a BRD4-binding moiety bound to a VHL ligand via a linker. Synonyms: ARV 771; ARV771; (2S,4R)-1-((S)-2-(tert-butyl)-15-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide; L-Prolinamide, N- [2- [3- [2- [ [2- [ (6S) -4- (4-chlorophenyl) -2, 3, 9-trimethyl-6H-thieno [3, 2-f] [1, 2, 4] triazolo [4, 3-a] [1, 4] diazepin-6-yl] acetyl] amino] ethoxy] propoxy] acetyl] -3-methyl-L-valyl-4-hydroxy-N- [ (1S) -1- [4- (4-methyl-5-thiazolyl) phenyl] ethyl] -, (4R)-; N- ({3-[2- ({[ (6S) -4- (4-Chlorophenyl) -2, 3, 9-trimethyl-6H-thieno[3, 2-f][1, 2, 4]triazolo[4, 3-a][1, 4]diazepin-6-yl]acetyl}amino) ethoxy]propoxy}acetyl) -3-methyl-L-valyl- (4R) -4-hydroxy-N-{ (1S) -1-[4- (4-methyl-1, 3-thiazol-5-yl) phenyl]ethyl}-L-prolinamide. Grades: ≥95%. CAS No. 1949837-12-0. Molecular formula: C49H60ClN9O7S2. Mole weight: 986.64. | |
| Arylomycin A2 | Arylomycin A is a lipopeptide compound with double aryl bridge produced by Streptomyces sp. Tu 6076. It has anti-Gram-positive bacteria activity. The most sensitive bacteria is Rhodococcus Ehmpolis. Molecular formula: C42H60N6O11. Mole weight: 824.97. | |
| Arylomycin B1 | Arylomycin B is a lipopeptide compound with double aryl bridge produced by Streptomyces sp. Tu 6075. It has anti-Gram-positive bacteria activity. The most sensitive bacteria is Rhodococcus Ehmpolis. The B series compounds are more active than the corresponding A series compounds. Molecular formula: C42H59N7O13. Mole weight: 869.97. | |
| Arylsulfatase E isoform 3 (503-517) | Arylsulfatase E isoform 3 (503-517) is a peptide derived from Arylsulfatase E isoform 3. Arylsulfatase E is a member of the arylsulfatase subfamily of sulfatase enzymes that catalyze the hydrolysis of sulfate esters. Synonyms: ARSE isoform 3 (503-517). | |
| AS-041164 | The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism. AS-041164 is a highly potent and selective PI3Kγ inhibitor that inhibits PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ with IC50 values of 240 nM, 1.45 μM, 70 nM and 1.70 μM, respectively. It also blocks RANTES-induced neutrophil migration and displays anti-inflammatory activity in various in vivo rodent models. Synonyms: 5-Benzo[1,3]dioxol-5-ylmethylene-thiazolidine-2,4-dione. Grades: ≥98%. CAS No. 6318-41-8. Molecular formula: C11H7NO4S. Mole weight: 249.2. | |
| AS101 | AS101 is a synthetic non-toxic tellurium derivative, structurally similar to cisplatin, with immuno-modulating, antiviral, and hair growth-promoting activities. This agent is also a potent inducer of IL-1 and IL-6. Accordingly, ammonium trichlorotellurate may protect against chemotherapy-induced alopecia. Synonyms: AS-101; IVX-Q-101; PRX-0001; PRX-0002; PRX-001; WAX-120337; IVXQ-101; AS101; IVXQ101; PRX0001; PRX0002; PRX001;WAX120337; AS 101; IVX Q 101; PRX 0001; PRX 0002; PRX 001; WAX 120337; IVXQ 101; US brand name: Ossirene; IVX-Q-101. Ammonium trichloro(dioxoethylene-O,O') tellurate. CAS No. 106566-58-9. Molecular formula: C2H4Cl3O2Te.H4N. Mole weight: 312.049. | |
| AS-183 | AS-183 is an enzyme inhibitor produced by Scedosporium sp. SPC-15549. Synonyms: 3(2H)-Furanone, 2-hydroxy-2,4-dimethyl-5-(1,3,5,7-tetramethylnonyl)-. Grades: >98%. CAS No. 147317-12-2. Molecular formula: C19H34O3. Mole weight: 310.47. | |
| AS 1842856 | AS 1842856 is a potent and selective inhibitor of Forkhead box protein O1 transcription factor (FoxO1; IC50 = 33 nM). AS 1842856 reduces glucose production in dose manner via the inhibition of glucose-6 phosphatase and phosphoenolpyruvate carboxykinase mRNA levels in a rat hepatic cell line. AS 1842856 is promisingly to be a therapy of type 2 diabetes mellitus and obesity. Uses: Potential treatment of type 2 diabetes mellitus and obesity. Synonyms: AS1842856; AS-1842856; AS 1842856. 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid. Grades: 99%. CAS No. 836620-48-5. Molecular formula: C18H22FN3O3. Mole weight: 347.38. | |
| AS-186c | AS-186c is an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor produced by Penicillum asperosporum KY1635. The IC50 for inhibiting ACAT was 11.5 μmol/L. Synonyms: 1-(7-{2-[2,6-dihydroxy-3-(3-methylbut-2-en-1-yl)benzoyl]-3-hydroxy-5-methylphenyl}-8,12-dihydroxy-4-methoxy-10-methyl-5-oxo-7,8-dihydro-5H-dibenzo[b,h][1,5]dioxonin-3-yl)-3-methylbutyl acetate. Molecular formula: C43H46O12. Mole weight: 754.82. | |
| AS-186d | AS-186d is an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor produced by Penicillum asperosporum KY1635. The IC50 for inhibiting ACAT was 12.4 μmol/L. Synonyms: 1-(8,12-dihydroxy-7-{3-hydroxy-2-[6-hydroxy-3-(1-hydroxy-3-methylbutyl)-2-methoxybenzoyl]-5-methylphenyl}-4-methoxy-10-methyl-5-oxo-7,8-dihydro-5H-dibenzo[b,h][1,5]dioxonin-3-yl)-3-methylbutyl acetate. Molecular formula: C44H50O13. Mole weight: 786.86. | |
| AS 1949490 | AS1949490 has been found to be a selective SHIP2 phosphatase inhibitor and show antidiabetic activities. Synonyms: AS1949490; AS-1949490; AS 1949490; 3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide. Grades: ≥99% by HPLC. CAS No. 1203680-76-5. Molecular formula: C20H18ClNO2S. Mole weight: 371.88. | |
| AS-2444697 HCl | AS-2444697 is a pootent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor (IC50 = 21 nM) with 30-fold selectivity for IRAK4 over IRAK1. AS2444697 significantly reduced or showed a decreasing trend in expression and levels of these inflammatory parameters. Synonyms: N-(3-carbamoyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide hydrochloride; AS-2444697; AS 2444697; AS2444697; AS-2444697 HCl; AS-2444697 hydrochloride. CAS No. 1287665-60-4. Molecular formula: C19H21ClN6O4. Mole weight: 432.86. | |
| AS-252424 | AS-252424 is a novel, potent PI3Kγ inhibitor (IC50 of 30 nM) with a 30-fold selectivity for PI3Kγ than PI3Kα, and low inhibitory activity towards PI3Kδ/&beta. Synonyms: AS252424; AS 252424; AS-252424. Grades: >98%. CAS No. 900515-16-4. Molecular formula: C14H8FNO4S. Mole weight: 305.28. | |
| AS 252424 bispotassium salt | AS 252424 bispotassium salt is the potassium salt form of AS 252424, which is a potent and selective PI3K p110γ inhibitor. Synonyms: AS 252424 bispotassium salt; AS252424 bispotassium salt; AS-252424 bispotassium salt; dipotassium (5Z)-5-[[5-(4-fluoro-2-oxidophenyl)furan-2-yl]methylidene]-4-oxo-1,3-thiazol-2-olate. Grades: 99%. Molecular formula: C14H6FNO4S.K2. Mole weight: 381.46. | |
| AS-35 | AS-35 is used as an antiallergic drug. It controls allergic diseases by inhibiting eosinophil activation. Uses: As-35 is used as an antiallergic drug. Synonyms: AS 35; AS35; AS-35; 3-(1H-Tetrazol-5-yl)-9-[[[2-propyl-3-hydroxy-4-(methylcarbonyl)phenyl]oxy]methyl]-4H-pyrido[1,2-a]pyrimidin-4-one;AS35;4H-Pyrido(1,2-a)pyrimidin-4-one, 9-((4-acetyl-3-hydroxy-2-propylphenoxy)methyl)-3-(1H-tetrazol-5-yl)-;9-((4-Acetyl-3-hydroxy-2-propylphenoxy)methyl)-3-(1H-tetrazol-5-yl)-4H-pyrido(1,2-a)pyrimidin-4-one. Grades: >98%. CAS No. 108427-72-1. Molecular formula: C21H20N6O4. Mole weight: 420.42. | |
| AS-604850 | AS-604850 is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 250 nM, over 80-fold selectivity for PI3Kγ than PI3Kδ/β, and 18-fold more selective for PI3Kγ than PI3K&alpha. Synonyms: AS604850; AS 604850; AS-604850. PI3K gamma inhibitor; PI 3-Kgamma Inhibitor II; (5E)-5-[(2,2-Difluoro-1,3-benzodioxol-5-YL)methylene]-1,3-thiazolidine-2,4-dione. Grades: 98%. CAS No. 648449-76-7. Molecular formula: C11H5F2NO4S. Mole weight: 285.211. | |
| AS-605240 | AS605240 is a selective PI3Kgamma inhibitor, has been proved effective on several inflammatory diseases. Orally administration of AS605240 significantly prevented lung inflammation and reduced collagen deposition. AS605240 also inhibited augmented expression of TNF-alpha and IL-1beta induced by bleomycin instillation. AS605240 may be a useful in treating inflammation diseases. AS605240 may represent a promising novel agent for the future therapy of pulmonary fibrosis. Synonyms: AS 605240; AS605240; AS-605240. Grades: 0.98. CAS No. 648450-29-7. Molecular formula: C12H7N3O2S. Mole weight: 257.267. | |
| AS-605240 potassium salt | Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. AS-605240 inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively. AS-605240 also inhibits C5a-mediated phosphorylation of protein kinase B in RAW 264 cells with an IC50 value of 90 nM. AS-605240 potassium salt is the potassium salt form of AS-605240, which increase the water-solubility. Synonyms: AS-605240. Grades: ≥98%. Molecular formula: C12H6N3O2S·K. Mole weight: 295.4. | |
| AS 8351 | AS 8351 has been found to show the activity in inducing reprogramming of human fetal lung fibroblasts into functional cardiomyocytes. Synonyms: AS-8351; AS-8351; AS-8351; 2-Hydroxy-1-naphthaldehyde isonicotinoylhydrazone. Grades: ≥98% by HPLC. CAS No. 796-42-9. Molecular formula: C17H13N3O2. Mole weight: 291.30. | |
| ASB14780 | ASB14780 is a potent and oral inhibitor of cytosolic phospholipase A2α (cPLA2α; IC50 = 0.020 μM in vitro and 0.54 - 0.64 μM in whole blood assay) with anti-inflammatory property in ear edema and asthma models. ASB14780 has the potential for the treatment of nonalcoholic fatty liver diseases including fatty liver and hepatic fibrosis. ASB14780 significantly attenuated expression of smooth muscle a-actin (a-SMA) protein and the mRNA expression of collagen 1a2, a-SMA and TGFb1 in the liver, as well as the expression of monocyte/macrophage markers. Synonyms: ASB14780; ASB 14780; ASB-14780; 3-(3-Phenethyl-1-(4-phenoxyphenyl)-1H-indol-5-yl)propanoic acid, 2-amino-2-(hydroxymethyl)-1,3-propanediol; 3-[1-(4-Phenoxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid, 2-amino-2-(hydroxymethyl)-1,3-propanediol. Grades: 99%. CAS No. 1069046-00-9. Molecular formula: C31H27NO3.C4H11NO3. Mole weight: 582.69. | |
| Ascalin | Ascalin is produced by Allium cepa var. aggregatum. It has antifungal activity against B.cinerea. Ascalin also inhibits HIV-1 reverse transcriptase with an IC50 of 10 μM. | |
| Ascamycin | Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces sp. JCM9888. The MIC values of Ascamycin against Xanthomonas citri, Xanthomonas oryzae and Mycobacterium phlei are 0.4 μg/mL, 12.5 μg/mL and 12.5 μg/mL, respectively. Synonyms: (+)-5'-O-[[(S)-2-Amino-1-oxopropyl]aminosulfonyl]-2-chloroadenosine; 2-Chloro-5'-O-[(L-alanylamino)sulfonyl]adenosine; 2-Chloro-5'-O-[[(S)-2-amino-1-oxopropyl]sulfamoyl]adenosine; 5'-O-{[(2S)-2-Amino-1-hydroxypropylidene]sulfamoyl}-2-chloroadenosine. Grades: ≥95%. CAS No. 91432-48-3. Molecular formula: C13H18ClN7O7S. Mole weight: 451.84. | |
| Ascaphin-1 | Ascaphin-1 is produced by Ascaphus truei. Ascaphin-1 is an antimicrobial peptide that shows higher potency against Gram-negative bacteria than against Gram-positive bacteria. It has a very week hemolytic activity. | |
| Ascaphin-1M | Ascaphin-1M is produced by Alsodes montanus. It has antimicrobial activity. | |
| Ascaphin-2 | Ascaphin-2 is isolated from norepinephrine-stimulated skin secretions of A. truei and was shown to possess growth inhibitory activity against Escherichia coli and Staphylococcus aureus. | |
| Ascaphin-3 | Ascaphin-3 is produced by Ascaphus truei. Ascaphin-3 is an antimicrobial peptide that shows higher potency against Gram-negative bacteria than against Gram-positive bacteria. It has a very week hemolytic activity. | |
| Ascaphin-3M | Ascaphin-3M is produced by Alsodes montanus. It has antimicrobial activity. | |
| Ascaphin-4 | Ascaphin-4 is produced by Ascaphus truei. Ascaphin-4 is an antimicrobial peptide that shows higher potency against Gram-negative bacteria than against Gram-positive bacteria. It has a very week hemolytic activity. | |
| Ascaphin-4M | Ascaphin-4M is produced by Alsodes montanus. It has antimicrobial activity. | |
| Ascaphin-5 | Ascaphin-5 is produced by Ascaphus truei. Ascaphin-5 is an antimicrobial peptide that shows higher potency against Gram-negative bacteria than against Gram-positive bacteria. It has a very week hemolytic activity. | |
| Ascaphin-5M | Ascaphin-5M is an antimicrobial peptide produced by Alsodes montanus (North America inland frog). It has antimicrobial activity. Synonyms: Gly-Ile-Lys-Asp-Trp-Ile-Lys-Gly-Ala-Ala-Lys-Thr-Leu-Ile-Lys-Thr-Val-Ala-Ser-His-Ile-Ala-Asn-Gln. Grades: >98%. Molecular formula: C116H195N33O32. Mole weight: 2564.03. | |
| Ascaphin-6 | Ascaphin-6 is an antimicrobial peptide produced by Ascaphus truei (Coastal tailed frog). It shows higher potency against Gram-negative bacteria than against Gram-positive bacteria and has a very week hemolytic activity. Synonyms: Gly-Phe-Lys-Asp-Trp-Ile-Lys-Gly-Ala-Ala-Lys-Lys-Leu-Ile-Lys-Thr-Val-Ala-Ser-Ser-Ile-Ala-Asn-Glu; glycyl-L-phenylalanyl-L-lysyl-L-aspartyl-L-tryptophyl-L-isoleucyl-L-lysylglycyl-L-alanyl-L-alanyl-L-lysyl-L-lysyl-L-leucyl-L-isoleucyl-L-lysyl-L-threonyl-L-valyl-L-alanyl-L-seryl-L-seryl-L-isoleucyl-L-alanyl-L-asparaginyl-L-glutamic acid. Grades: >98%. CAS No. 722538-44-5. Molecular formula: C118H195N31O33. Mole weight: 2576.03. | |
| Ascaphin-7 | Ascaphin-7 is an antimicrobial peptide produced by Ascaphus truei (Coastal tailed frog). It shows higher potency against Gram-negative bacteria than against Gram-positive bacteria and has a very week hemolytic activity. Synonyms: H-Gly-Phe-Lys-Asp-Trp-Ile-Lys-Gly-Ala-Ala-Lys-Lys-Leu-Ile-Lys-Thr-Val-Ala-Ser-Ser-Ile-Ala-Asn-Gln-OH; glycyl-L-phenylalanyl-L-lysyl-L-aspartyl-L-tryptophyl-L-isoleucyl-L-lysylglycyl-L-alanyl-L-alanyl-L-lysyl-L-lysyl-L-leucyl-L-isoleucyl-L-lysyl-L-threonyl-L-valyl-L-alanyl-L-seryl-L-seryl-L-isoleucyl-L-alanyl-L-asparaginyl-L-glutamine. Grades: ≥98%. CAS No. 722538-45-6. Molecular formula: C118H196N32O32. Mole weight: 2575.04. | |
| Ascaphin-7M | Ascaphin-7M is an antimicrobial peptide produced by Alsodes montanus (North America inland frog). It has antimicrobial activity. Synonyms: Gly-Phe-Lys-Asp-Trp-Ile-Lys-Ser-Ala-Ala-Lys-Lys-Leu-Ile-Lys-Thr-Val-Ala-Ser-Asn-Ile-Ala-Asn-Gln; glycyl-L-phenylalanyl-L-lysyl-L-aspartyl-L-tryptophyl-L-isoleucyl-L-lysyl-L-seryl-L-alanyl-L-alanyl-L-lysyl-L-lysyl-L-leucyl-L-isoleucyl-L-lysyl-L-threonyl-L-valyl-L-alanyl-L-seryl-L-asparaginyl-L-isoleucyl-L-alanyl-L-asparaginyl-L-glutamine. Grades: >98%. Molecular formula: C120H199N33O33. Mole weight: 2632.11. | |
| Ascaphin-8 | Ascaphin-8 is an antimicrobial peptide produced by Ascaphus truei (Coastal tailed frog). It shows similar potency against Gram-negative bacteria and Gram-positive bacteria and has a high hemolytic activity. Synonyms: Gly-Phe-Lys-Asp-Leu-Leu-Lys-Gly-Ala-Ala-Lys-Ala-Leu-Val-Lys-Thr-Val-Leu-Phe-NH2; glycyl-L-phenylalanyl-L-lysyl-L-alpha-aspartyl-L-leucyl-L-leucyl-L-lysyl-glycyl-L-alanyl-L-alanyl-L-lysyl-L-alanyl-L-leucyl-L-valyl-L-lysyl-L-threonyl-L-valyl-L-leucyl-L-phenylalaninamide. Grades: ≥95%. CAS No. 722538-46-7. Molecular formula: C97H164N24O22. Mole weight: 2018.53. | |
| Asciminib | Asciminib, also known as ABL-001, is a potent and selective allosteric Bcr-Abl inhibitor. Asciminib inhibits Ba/F3 cell growth with an IC50 of 0.25 nM. Uses: Tyrosine kinase inhibitors. Synonyms: ABL-001; ABL 001; ABL001; N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypyrrolidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide. CAS No. 1492952-76-7. Molecular formula: C20H18ClF2N5O3. Mole weight: 449.843. | |
| Ascochin | Ascochin is a fungal metabolite found in Ascochyta, which has antifungal, antibacterial and phytotoxic activities. Synonyms: (S)-(+)-Ascochin. Grades: >95% by HPLC. CAS No. 935699-58-4. Molecular formula: C12H10O5. Mole weight: 234.2. | |
| Ascochitine | Ascochitine is an antibiotic produced by Ascochita fabae and Asc. pisi. It is mainly resistant to fungi such as Xanthomonas oryzae and Xanthomonas oryzae, and has a control effect on some diseases of rice and tomato. Molecular formula: C15H16O5. Mole weight: 276.28. | |
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