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Enoxacin
Enoxacin is an oral broad-spectrum fluoroquinolone antibacterial agent used in the treatment of urinary tract infections and gonorrhea. Insomnia is a common adverse effect. Uses: Anti-bacterial agents. Synonyms: R41468; R41468; R-41468; PD 107779; PD-107779; PD107779; Penetrex; Enoxacine; Comprecin. Grade: >98%. CAS No. 74011-58-8. Molecular formula: C15H17FN4O3. Mole weight: 320.32.
Enrofloxacin
Enrofloxacin is a fluoroquinolone antibiotic that prevents DNA superhelix and DNA synthesis by inhibiting bacterial DNA gyrase (a type II topoisomerase). It can be used for bacterial diseases caused by sensitive bacteria in livestock and small animals. Synonyms: Baytril; Enrofloxacine; CFPQ; Enrofloxacino; Bay Vp 2674. Grade: >98%. CAS No. 93106-60-6. Molecular formula: C19H22FN3O3. Mole weight: 359.39.
Enrofloxacin hydrochloride
Enrofloxacin hydrochloride is a fluoroquinolone antibiotic commonly used in veterinary medicine. Synonyms: Enrofloxacin HCl. CAS No. 112732-17-9. Molecular formula: C19H22FN3O3.HCl. Mole weight: 395.86.
ent-Amyloid β-Protein (1-42)
ent-Amyloid β-Protein (1-42) has similar properties to all-L Aβ, forming ion channels in lipid bilayer. Synonyms: All-D Aβ (1-42); H-D-Asp-D-Ala-D-Glu-D-Phe-D-Arg-D-His-D-Asp-D-Ser-Gly-D-Tyr-D-Glu-D-Val-D-His-D-His-D-Gln-D-Lys-D-Leu-D-Val-D-Phe-D-Phe-D-Ala-D-Glu-D-Asp-D-Val-Gly-D-Ser-D-Asn-D-Lys-Gly-D-Ala-D-Ile-D-Ile-Gly-D-Leu-D-Met-D-Val-Gly-Gly-D-Val-D-Val-D-Ile-D-Ala-OH; D-alpha-Aspartyl-D-alanyl-D-alpha-glutamyl-D-phenylalanyl-D-arginyl-D-histidyl-D-alpha-aspartyl-D-serylglycyl-D-tyrosyl-D-alpha-glutamyl-D-valyl-D-histidyl-D-histidyl-D-glutaminyl-D-lysyl-D-leucyl-D-valyl-D-phenylalanyl-D-phenylalanyl-D-alanyl-D-alpha-glutamyl-D-alpha-aspartyl-D-valylglycyl-D-seryl-D-asparaginyl-D-lysylglycyl-D-alanyl-D-isoleucyl-D-isoleucylglycyl-D-leucyl-D-methionyl-D-valylglycylglycyl-D-valyl-D-valyl-D-isoleucyl-D-alanine. Grade: 95%. CAS No. 342896-25-7. Molecular formula: C203H311N55O60S. Mole weight: 4514.03.
Entecavir monohydrate
Entecavir triphosphate is a highly potent inhibitor of wild-type HBV Pol and is 100- to 300-fold more potent than lamivudine triphosphate against 3TC-resistant HBV Pol. It competes with dGTP to be incorporated into viral DNA. Uses: Antiviral agents. Synonyms: Entecavir (monohydrate); UNII-5968Y6H45M; 5968Y6H45M. Grade: 98%. CAS No. 209216-23-9. Molecular formula: C12H15N5O3.H2O. Mole weight: 295.29.
Enterocin
It is produced by the strain of Streptomyces candidus var. entrosttaticus WS-8095, Str. viridochromogenes M-127. It has the activity of anti-gram-positive bacteria and negative bacteria, has the synergistic effect with streptomycin and chloramphenicol, and has the effect of weeding and affecting the metabolism of isoleucine. Synonyms: Vulgamycin; 3,6-Methanocyclopenta(c)pyran-1(3H)-one, 7-benzoylhexahydro-4a,6,7a,8-tetrahydroxy-5-(4-methoxy-2-oxo-2H-pyran-6-yl)-, (3R,4aR,5S,6S,7S,7aS,8R)-; [3R-(3α,4aβ,5α,6β,7β,7aβ,8R*)]-7-Benzoylhexahydro-4a,6,7a,8-tetrahydroxy-5-(4-methoxy-2-oxo-2H-pyran-6-yl)-3,6-methanocyclopenta[c]pyran-1(3H)-one. Grade: >95% by HPLC. CAS No. 59678-46-5. Molecular formula: C22H20O10. Mole weight: 444.39.
Epianhydrochlortetracycline hydrochloride
A secondary degradation product formed by dehydration of epichlortetracycline at the C6 position to aromatise the B ring. It is an important standard for monitoring tetracycline stability. Synonyms: 4-Epianhydrochlortetracycline hydrochloride; [4R-(4α,4aβ,12aβ)]-7-Chloro-4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-2-naphthacenecarboxamide Monohydrochloride; 4-Epianhydrochlortetracycline HCl. Grade: >95% by HPLC. CAS No. 158018-53-2. Molecular formula: C22H22Cl2N2O7. Mole weight: 497.33.
Epicillin
It is produced by the strain of Semisynthetic broad-spectrum penicillin. Its antibacterial spectrum, antibacterial activity, pharmacokinetic properties and curative effect are similar to Ampicillin. Synonyms: Dexacillin; Dihydroampicillin; Epicilline; Epicillinum; Epicilina; 6-((Amino-1,4-cyclohexadien-1-ylacetyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid (2S-(2alpha,5alpha,6beta,(S*)))-; 6-(D-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid; 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((amino-1,4-cyclohexadien-1-ylacetyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta(S*)))-. CAS No. 26774-90-3. Molecular formula: C16H21N3O4S. Mole weight: 351.43.
Epidaunorubicin
An impurity of Epirubicin, which is an anthracycline topoisomerase inhibitor used as an antineoplastic agent. Synonyms: 4'-epidaunorubicin; Epirubicin EP Impurity F; 5,12-Naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-beta-L-arabino-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)-; (1S,3S)-3-Acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl 3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranoside; (8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione; (8S-cis)-4'-Epidaunorubicin; 4'-epi-Daunomycin; NSC 249333; 4'-Epi-daunorubicin; epi-Daunorubicin. Grade: ≥95%. CAS No. 57918-24-8. Molecular formula: C27H29NO10. Mole weight: 527.52.
Epidermal Growth Factor Receptor Peptide acetate
Epidermal Growth Factor Receptor Peptide exists on the cell surface and is activated by the binding of its specific ligands. EGFR belongs to the tyrosine kinase receptor (RTK) ErbB family. Synonyms: H-Asp-Val-Val-Asp-Ala-Asp-Glu-Tyr-Leu-Ile-Pro-Gln-OH.CH3CO2H; L-alpha-aspartyl-L-valyl-L-valyl-L-alpha-aspartyl-L-alanyl-L-alpha-aspartyl-L-alpha-glutamyl-L-tyrosyl-L-leucyl-L-isoleucyl-L-prolyl-L-glutamine acetic acid; EGF Receptor (985-996) (human) acetate. Grade: ≥95%. Molecular formula: C63H97N13O25. Mole weight: 1436.52.
Epigallocatechin gallate
EGCG is an antioxidant extracted from green tea, reduces Aβ42-induced cell death in three different cell types and inhibits β-secretase (IC50 = 1.6 μM). (-)-Epigallocatechin gallate is a natural compound found in the woods of Acacia catechu (L.F.) Willd. It can be used in cosmetic material. Synonyms: EGCG cpd; epigallo-catechin gallate; epigallocatechin gallate; epigallocatechin-3-gallate; epigallocatechin-3-O-gallate; EGCG. Grade: >98%. CAS No. 989-51-5. Molecular formula: C22H18O11. Mole weight: 458.37.
epi-Ivermectin B1a
Epi-Ivermectin B1a is a degradation product produced by the reversible base-catalyzed isomerization of ivermectin B1a. It is less active than ivermectin against T. urticae (LC90s = 4.0 and 0.038 ppm, respectively). Synonyms: 5-O-demethyl-22,23-dihydro-avermectin A1a; 2-dehydro-4-dihydro Avermectin B1a; epi-dihydro Avermectin B1a; 22,23-dihydro Avermectin B1a; 2-epi-Ivermectin B1a; 2-epi-Ivermectin H2B1a. Grade: >95% by HPLC. Molecular formula: C48H74O14. Mole weight: 875.09.
Epirubicin
Epirubicin, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase. It is clinically active against a broad range of tumor types, including breast cancer, malignant lymphomas, soft tissue sarcomas, lung cancer, pleural mesothelioma, gastrointestinal cancer, head and neck cancer, ovarian cancer, prostatic carcinoma, transitional bladder carcinoma and so on. Synonyms: Pharmorubicin; Ellence; Epiadriamycin; Epidoxorubicin; 4'-Epiadriamycin; Epirubicine; Pidorubicine; NSC 256942; (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione; (8S-cis)-4'-Epidoxorubicin; (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranoside. Grade: >98%. CAS No. 56420-45-2. Molecular formula: C27H29NO11. Mole weight: 543.52.
Epirubicin Hydrochloride
Epirubicin HCl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase. Uses: Antibiotics, antineoplastic. Synonyms: epi-Doxorubicin HCl; (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione Hydrochloride; (8S-cis)-4'-Epidoxorubicin Hydrochloride; 4'-epi-Adriamycin Hydrochloride; Ellence; Epidoxorubicin Hydrochloride; Farmorubicin; Pharmorubicin; NSC-759195; 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-. Grade: >98%. CAS No. 56390-09-1. Molecular formula: C27H29NO11.HCl. Mole weight: 579.98.
Epitalon
Epitalon is a synthetic tetra-peptide used to regulate the cell cycle through up-regulation of telomerase activity showing anticancer and anti-tumor metastatic effect. Uses: Regulate the cell cycle through up-regulation of telomerase activity. Synonyms: H-Ala-Glu-Asp-Gly-OH; (S)-4-((S)-2-aminopropanamido)-5-(((S)-3-carboxy-1-((carboxymethyl)amino)-1-oxopropan-2-yl)amino)-5-oxopentanoic acid; BDM-E; Epitalon; L-Alanyl-L-α-glutamyl-L-α-aspartylglycine. Grade: ≥98%. CAS No. 307297-39-8. Molecular formula: C14H22N4O9. Mole weight: 390.35.
Epitetracycline hydrochloride
A degradation product of tetracycline formed by acid-catalysed isomerisation of the dimethylamino-group at C4. It is an antibiotic and a cell selection agent. It exhibits little antibacterial activity. Synonyms: 4-Epitetracycline hydrochloride; (4R,4aS,5aS,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide Hydrochloride; Quatrimycin Hydrochloride; [4R-(4α,4aβ,5aβ,6α,12aβ)]-4-(dimethylamino)-. 1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide Hydrochloride; 4-Epi-tetracycline monohydrochloride. Grade: >95% by HPLC. CAS No. 23313-80-6. Molecular formula: C22H24N2O8.HCl. Mole weight: 480.90.
Epothilon A
Epothilons A is a 16-membered macrolide antibiotic produced by the myxobacterium Sorangium cellulosum. It has strong cytotoxicity and has the effect of resisting plant pathogenic fungi. Uses: Antineoplastic agents. Synonyms: (-)-Epothilone A; Epo A; NSC-684362; (1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-5,7,9,9-tetramethyl-14-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-13,17-dioxabicyclo[14.1.0]heptadecane-8,12-dione. Grade: >98%. CAS No. 152044-53-6. Molecular formula: C26H39NO6S. Mole weight: 493.65.
Epothilon B
Epothilons B is a 16-membered macrolide antibiotic produced by the myxobacterium Sorangium cellulosum, which is used as a microtubule stabilization agent (EC0.01 = 1.8 μM). It has strong cytotoxicity and has the effect of resisting plant pathogenic fungi. Uses: Antineoplastic agents. Synonyms: Patupilone; (-)-Epothilone B. Grade: 98%. CAS No. 152044-54-7. Molecular formula: C27H41NO6S. Mole weight: 507.68.
Epoxomicin
Epoxomicin is a naturally occurring selective proteasome inhibitor with anti-inflammatory activity. Uses: Proteasome inhibitors. Synonyms: BU-4061T. Grade: >98%. CAS No. 134381-21-8. Molecular formula: C28H50N4O7. Mole weight: 554.72.
Eprinomectin
Eprinomectin is a semi-synthetic GABA signaling potentiator used to inhibit bacterial infections. It causes neuromuscular paralysis in microbes and parasites. Eprinomectin is an avermectin selected for development as a topical endectocide. Synonyms: Eprinex; Ivomec Eprinex; MK 397; MK-397; MK397. Grade: >98%. CAS No. 123997-26-2. Molecular formula: C50H75NO14. Mole weight: 914.13.
Eprinomectin B1a
It is a semi-synthetic 4''-epimethylamino analogue of avermectin B1b prepared by oxidation of the 4''-hydroxy moiety and reductive amination. Members of the Avermectin/Milbemycin class exert their insecticidal/anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells. Synonyms: (4''R)-4''-(Acetylamino)-5-O-demethyl-4''-deoxyavermectin A1a; Avermectin A1a, 4'-(acetylamino)-5-O-demethyl-4'-deoxy-, (4'R)-; Eprinomectin component B1a. Grade: >99% by HPLC. CAS No. 133305-88-1. Molecular formula: C50H75NO14. Mole weight: 914.13.
Eprinomectin B1b
It is a semi-synthetic analogue of avermectin B1b prepared by oxidation of the 4''-hydroxy moiety and reductive amination followed by acetylation. It is the minor component (<10%) of the commercial product for endo- and exo-parasite control, eprinomectin. It is a potent insecticide and acaricide. Synonyms: (4''R)-4''-(Acetylamino)-5-O-demethyl-25-de(1-methylpropyl)-4''-deoxy-25-(1-methylethyl)avermectin A1a; Eprinomectin component B1b. Grade:>99% by HPLC. CAS No. 133305-89-2. Molecular formula: C49H73NO14. Mole weight: 900.10.
Eptifibatide
An arginin-glycin-aspartat-mimetic, reversibly binds to platelets to reduce the risk of cardiac ischemic events. Uses: Platelet aggregation inhibitors. Synonyms: L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-α-aspartyl-L-tryptophyl-L-prolyl-, cyclic (1→6)-disulfide; Eftifibatide; Integrelin; Integrilin; Intrifiban; Mpr-Har-Gly-Asp-Trp-Pro-Cys-NH2(Mpr&Cys bridge); Deamino-cysteinyl-L-homoarginyl-glycyl-L-alpha-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide (1->7)-disulfide; deamino-Cys-hArg-Gly-Asp-Trp-Pro-Cys-NH2 (Disulfide bridge: Cys1-Cys7). Grade: 98%. CAS No. 188627-80-7. Molecular formula: C35H49N11O9S2. Mole weight: 831.97.
Eptifibatide acetate
Eptifibatide acetate, an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class, is a cyclic heptapeptide constructed from 6 amino acids and a mercaptopropionyl residue. It reversibly binds to platelets to reduce the risk of cardiac ischemic events. Synonyms: L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-α-aspartyl-L-tryptophyl-L-prolyl-, cyclic (1→6)-disulfide, acetate (1:x); deamino-Cys(1)-hArg-Gly-Asp-Trp-Pro-Cys(1)-NH2.xCH3CO2H; Deamino-cysteinyl-L-homoarginyl-glycyl-L-alpha-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide (1->7)-disulfide acetate salt; Mpr-Har-Gly-Asp-Trp-Pro-Cys-NH2 (Mpr&Cys bridge) acetate. Grade: ≥95%. CAS No. 881997-86-0. Molecular formula: C35H49N11O9S2.xC2H4O2. Mole weight: 831.97 (free base).
Eptifibatide monoacetate
Eptifibatide monoacetate, an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class, is a cyclic heptapeptide constructed from 6 amino acids and a mercaptopropionyl residue. It reversibly binds to platelets to reduce the risk of cardiac ischemic events. Synonyms: L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-α-aspartyl-L-tryptophyl-L-prolyl-, cyclic (1→6)-disulfide, acetate (1:1); deamino-Cys(1)-hArg-Gly-Asp-Trp-Pro-Cys(1)-NH2.CH3CO2H; Deamino-cysteinyl-L-homoarginyl-glycyl-L-alpha-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide (1->7)-disulfide acetic acid; Eptifibatide acetate; Mpr-Har-Gly-Asp-Trp-Pro-Cys-NH2 (Mpr&Cys bridge) acetate. Grade: ≥95%. CAS No. 1248559-53-6. Molecular formula: C35H49N11O9S2.C2H4O2. Mole weight: 892.02.
Equisetin
Equisetin is an antibiotic produced by Fusarium equiseti NRRL 5537. Activity against gram-positive bacteria. Synonyms: (-)-Equisetin. Grade: >98%. CAS No. 57749-43-6. Molecular formula: C22H31NO4. Mole weight: 373.48.
Eravacycline
Eravacycline, also known as TP-434, a novel antibiotic. Eravacycline showed potent broad-spectrum activity against 90% of the isolates (MIC90) in each panel at concentrations ranging from 0.008 to 2 μg/ml for all species panels except those of Pseudomonas aeruginosa and Burkholderia cenocepacia (MIC90 values of 32 μg/ml for both organisms). Synonyms: TP-434; TP 434; TP434. Grade: 98%. CAS No. 1207283-85-9. Molecular formula: C27H31FN4O8. Mole weight: 558.56.
Erlotinib hydrochloride
Erlotinib HCl potently inhibits EGFR activation in intact cells including HNS human head and neck tumor cells (IC50 = 20 nM), DiFi humancolon cancer cells and MDA MB-468 human breast cancer cells. Uses: Antineoplastic agents. Synonyms: OSI-744; OSI744; OSI 744; Tarceva; 4-(m-Ethynylanilino)-6,7-bis(2-methoxyethoxy)quinazoline monohydrochloride; 6,7-bis(2-methoxyethoxy)-4-(3-ethynylanilino)quinazoline hydrochloride. Grade: >98%. CAS No. 183319-69-9. Molecular formula: C22H23N3O4.HCl. Mole weight: 429.90.
Ertapenem
Ertapenem has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of ertapenem results from the inhibition of cell wall synthesis and is mediated through ertapenem binding to penicillin binding proteins (PBPs). In Escherichia coli, it has strong affinity toward PBPs 1a, 1b, 2, 3, 4 and 5 with preference for PBPs 2 and 3. Ertapenem is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. Ertapenem is hydrolyzed by metallo-beta-lactamases. Ertapenem has been shown to be active against most isolates of the following microorganisms in vitro and in clinical infections. Synonyms: (1R,5S,6S,8R,2'S,4'S)-2-(2-(3-carboxyphenylcarbamoyl)pyrrolidin-4-ylthio)-6-(1-hydroxyethyl)-1-methylcarbapenem-3-carboxylic acid; 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(((3S,5S)-5-(((3-carboxyphenyl)amino)carbonyl)-3-pyrrolidinyl)thio)-6-((1R)-1-hydroxyethyl-4-methyl-7-oxo-, (4R,5S,6S)-; 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-((5-(((3-carboxyphenyl)amino)carbonyl)-3-pyrrolidinyl)thio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-, (4R-(3(3S*,5S*),4α,5β,6β(R*)))-. Grade: 95%. CAS No. 153832-46-3. Molecular formula: C22H25N3O7S. Mole weight: 475.52.
Ertapenem Disodium
It is a long-acting, broad-spectrum antibiotic that is in the β-lactam subclass known as carbapenems. It inhibits the synthesis of bacterial cell walls by attaching to penicillin-binding proteins. It has activity against Gram-positive and Gram-negative bacteria. Synonyms: Ertapenem sodium; 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-((5-(((3-carboxyphenyl)amino)carbonyl)-3-pyrrolidinyl)thio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-, disodium salt, (4R-(3(3S*,5S*),4alpha,5beta,6beta(R*)))-; L 749. Grade: ≥97%. CAS No. 153832-38-3. Molecular formula: C22H23N3Na2O7S. Mole weight: 519.48.
Ertapenem Sodium
Ertapenem Sodium is the sodium salt of ertapenem. Ertapenem has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of ertapenem results from the inhibition of cell wall synthesis and is mediated through ertapenem binding to penicillin binding proteins (PBPs). In Escherichia coli, it has strong affinity toward PBPs 1a, 1b, 2, 3, 4 and 5 with preference for PBPs 2 and 3. Ertapenem is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. Ertapenem is hydrolyzed by metallo-beta-lactamases. Ertapenem has been shown to be active against most isolates of the following microorganisms in vitro and in clinical infections. Synonyms: Invanz; Ertapenem sodium salt; MK-0826. Grade: 95% by HPLC. CAS No. 153773-82-1. Molecular formula: C22H24N3NaO7S. Mole weight: 497.50.
Erythromycin A
Erythromycin A is a group of 14-membered macrolide antibiotics produced by Streptomyces erythreus. Erythromycin A is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin (IC50=1.5 μg/ml). It has a good effect on fish whitehead and white mouth disease, gill rot disease and kidney disease. Erythromycin can be used as an alternative medicine for animals allergic to penicillin. Synonyms: erythromycin; E-Mycin; Erythrocin. CAS No. 114-07-8. Molecular formula: C37H67NO13. Mole weight: 733.93.
Erythromycin A Dihydrate
A highly purified form of erythromycin A, a major component found in erythromycin. Synonyms: Erythromycin A (dihydrate). CAS No. 59319-72-1. Molecular formula: C37H67NO13.2H2O. Mole weight: 769.95.
Erythromycin B
Erythromycin B is a minor co-metabolite of erythromycin produced by fermentation of Saccharopolyspora erythreae. Erythromycin B exhibits broad spectrum antibiotic activity against Gram-positive and Gram-negative bacteria. An impurity of Erythromycin. Uses: Anti-bacterial agents. Synonyms: Erythromycin B; Oxacyclotetradecane, erythromycin deriv.; 12-Deoxyerythromycin; Abbott 24091; Berythromycin. Grade: >95%. CAS No. 527-75-3. Molecular formula: C37H67NO12. Mole weight: 717.93.
Erythromycin C
A minor co-metabolite of erythromycin produced by saccharopolyspora erythreae. It exhibits a narrow spectrum of antibacterial activity, and it is much less active than erythromycin A and B. Synonyms: 3''-O-Demethylerythromycin A; Erythromycin Impurity 6. Grade: >98% by HPLC. CAS No. 1675-02-1. Molecular formula: C36H65NO13. Mole weight: 719.90.
Erythromycin EP Impurity B
A metabolite of Erythromycin. Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. Synonyms: N-Demethylerythromycin A; N-Desmethyl Erythromycin A; Des-N-methylerythromycin; Demethylerythromycin; USP Erythromycin Related Compound N; 3'-Demethylerythromyon; 11,13-hexamethyl-oxacyclotetradecane-2,10-dione. Grade: 95%. CAS No. 992-62-1. Molecular formula: C36H65NO13. Mole weight: 719.90.
Erythromycin EP Impurity D
An acid-catalyzed degradation product of Erythromycin. Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 57S ribosomal subunit, blocking the progression of nascent polypeptide chains. Synonyms: Anhydroerythromycin A; Anhydro Erythromycin A; 9-Deoxo-6,12-dideoxy-6,9:9,12-diepoxy-erythromycin; 6,9,12-Anhydroerythromycin A. Grade: >95%. CAS No. 23893-13-2. Molecular formula: C37H65NO12. Mole weight: 715.91.
Erythromycin Estolate
A macrolide antibiotic with a target spectrum similar to penicillin. Synonyms: Ilosone; Erythromycin Propionate Lauryl Sulfate; Eritroger; Eromycin. Grade: ≥98%. CAS No. 3521-62-8. Molecular formula: C52H93NO18S. Mole weight: 1056.39.
Erythromycin ethylsuccinate
Erythromycin Ethylsuccinate, an oral macrolide antibiotic produced by Streptomyces erythreus, reversibly binds to the 50S ribosome of bacteria, and inhibits protein synthesis. Synonyms: Pediamycin; EryPed; Wyamycin E; Erythromycin ethyl succinate; Erythromycin, 2'-(ethyl butanedioate); Erythroped; Erythromycin A Ethylsuccinate; (2S,3R,4S,6R)-4-(Dimethylamino)-2-{[(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyl-2,10-dioxooxacyclotetradecan-6-yl]oxy}-6-methyltetrahydro-2H-pyran-3-yl ethyl succinate; Erythromycin, mono(ethyl succinate) (ester); Succinic acid, ethyl ester, monoester with erythromycin; Anamycin; Arpimycin; Durapaediat; Monomycin; Paediathrocin; Refkas; Sigapedil. Grade: ≥98%. CAS No. 1264-62-6. Molecular formula: C43H75NO16. Mole weight: 862.05.
Erythromycin lactobionate
Erythromycin lactobionate is a soluble salt of erythromycin that is a macrolide antibiotic which inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. Erythromycin is effective against a host of bacterial genera, including Streptococcus, Staphylococcus, and Haemophilus. Synonyms: Erythromycin 4-O-β-D-galactopyranosyl-D-gluconate. CAS No. 3847-29-8. Molecular formula: C49H89NO25. Mole weight: 1092.22.
Erythromycylamine
Erythromycylamine is a macrolide antibiotic and an active metabolite of dirithromycin. It is active against a variety of bacteria, including strains of S. pyogenes, S. pneumoniae, L. monocytogenes and B. pertussis. A derivative of Erythromycin. Synonyms: (9S)-9-Amino-9-deoxoerythromycin; (9S)-9-Deoxy-9-aminoerythromycin A; (9S)-Erythromycylamine A; 9(S)-Erythromycylamine; BRL 42852ER; LY 024410; Dirithromycin EP Impurity A. Grade: >95%. CAS No. 26116-56-3. Molecular formula: C37H70N2O12. Mole weight: 734.96.
erythro-ω-Amino Sphingosine Biotinamide
Biotin Sphingosine is a derivative of sphingosine. It contains a biotin moiety linked to the ω-terminal of its fatty-acid chain. Biotin Sphingosine plays a key role in identifying sphingosine interaction with acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A). It is used in an assay for sphingosine kinase activity using biotinylated sphingosine and streptavidin-coated membranes. Synonyms: omega-biotinyl D-erythro-sphingosine; Biotin Sphingosine; (3aS,4S,6aR)-N-[(14E,16R,17S)-17-Amino-16,18-dihydroxy-14-octadecen-1-yl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide. Grade: >99%. CAS No. 752987-57-8. Molecular formula: C28H52N4O4S. Mole weight: 540.80.
Esperamicin A1
Esperamicin A1 is an enediyne antineoplastic antibiotic hybrid containing an anthranilate moiety. Esperamicin A1 is isolated from the bacterium Actinomadura verrucosospora. Synonyms: Esperamicin A(sub 1). CAS No. 99674-26-7. Molecular formula: C59H80N4O22S4. Mole weight: 1325.55.
Esterastin
Esterastin is a lipase inhibitor produced by Streptomyces lavendulae MD4-C1. Synonyms: [(2S,4Z,7Z)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]trideca-4,7-dien-2-yl] (2S)-2-acetamido-4-amino-4-oxobutanoate. CAS No. 67655-93-0. Molecular formula: C28H46N2O6. Mole weight: 506.67.
Etamycin A
Etamycin A is an ester peptide antibiotic produced by Streptomyces sp. Activity against gram-positive bacteria and mycobacteria. Synonyms: Viridogrisein I; Viridogrisein; Etamycin. Grade: >98%. CAS No. 299-20-7. Molecular formula: C44H62N8O11. Mole weight: 879.01.
Etelcalcetide
Etelcalcetide is a calcimimetic agent used for the treatment of secondary hyperparathyroidism in patients chronic kidney disease (CKD) undergoing hemodialysis. It effects via binding to and stimulating the calcium-sensing receptor in the parathyroid gland. Uses: The treatment of secondary hyperparathyroidism. Synonyms: Velcalcetide; telcalcetide; AMG-416; KAI-4169; ONO-5163; Parsabiv. CAS No. 1262780-97-1. Molecular formula: C38H73N21O10S2. Mole weight: 1048.26.
Ethambutol
Ethambutol is a synthetic anti-tuberculosis antibiotic. Ethambutol is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases. It directly affects two polymers, arabinogalactan (AG) and lipoarabinomannan (LAM) in Mycobacterium smegmatis. It is effective against actively growing microorganisms of the genus Mycobacterium, including M. tuberculosis and is potency against M. tuberculosis (H37Rv). Uses: Antitubercular agents. Synonyms: Myambutol; Emb. Grade: >98%. CAS No. 74-55-5. Molecular formula: C10H24N2O2. Mole weight: 204.31.
Ethambutol dihydrochloride
Ethambutol dihydrochloride is a hydrochloride salt of Ethambutol. Ethambutol is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases. Uses: Antitubercular agents. Synonyms: CL40881; CL 40881; CL-40881; Myambutol; Dadibutol. Grade: >98%. CAS No. 1070-11-7. Molecular formula: C10H24N2O2.2HCl. Mole weight: 277.23.
Ethionamide
Ethionamide is an antibiotic used in the treatment of tuberculosis. Ethionamide is a part of a group of drugs used in the treatment of drug resistant TB called thioamides. Synonyms: Bayer 5312; Bayer5312; Bayer-5312. Grade: >98%. CAS No. 536-33-4. Molecular formula: C8H10N2S. Mole weight: 166.24.
Ethoxylated (2) bisphenol A diacrylate
Ethoxylated (2) bisphenol A diacrylate. CAS No. 64401-02-1. Molecular formula: C25H28O6. Mole weight: 424.50.
Ethoxylated (2) bisphenol A dimethacrylate
Ethoxylated (2) bisphenol A dimethacrylate. CAS No. 41637-38-1. Molecular formula: (C2H4O)n(C2H4O)nC23H24O4.
An impurity of Terbutaline, which is a β-Adrenergic receptor agonist and could be used as a bronchodilator agent. Synonyms: Ethyl 3,5-dibenzyloxybenzoate. CAS No. 50841-46-8. Molecular formula: C23H22O4. Mole weight: 362.425.
Ethyl 4-(4-(2-Bromobenzyl)piperazin-1-yl)benzoate-[d8] is the labelled analogue of Ethyl 4-(4-(2-Bromobenzyl)piperazin-1-yl)benzoate, which is an intermediate in the production of ABT 737. Synonyms: Ethyl 4-(4-(2-Bromobenzyl)piperazin-1-yl)benzoate-d8; 4-[4-[(2-Bromophenyl)methyl]-1-piperazinyl]benzoic Acid Ethyl Ester-d8. Grade: 98%. CAS No. 1246817-87-7. Molecular formula: C20H15D8BrN2O2. Mole weight: 411.36.
ETHYL 4-(BENZYLOXY)BENZOATE. Synonyms: RARECHEM AL BI 0087; 4-(BENZYLOXY)BENZOIC ACID ETHYL ESTER; ETHYL 4-(BENZYLOXY)BENZOATE; benzoic acid, 4-(phenylmethoxy)-, ethyl ester. CAS No. 56441-55-5. Molecular formula: C16H16O3. Mole weight: 256.3.
Ethyl 5-Benzyloxy-2-hydroxybenzoate
Ethyl 5-Benzyloxy-2-hydroxybenzoate is a reactant used in the preparation of N-(piperidylmethyl)benzamides as antiarrhythmics. Synonyms: 2-Hydroxy-5-(phenylmethoxy)benzoic Acid Ethyl Ester. CAS No. 83526-27-6. Molecular formula: C16H16O4. Mole weight: 272.3.
Everolimus is an inhibitor of mammalian target of rapamycin (mTOR) with an immunosuppressive activity which is comparable to that of rapamycin. It inhibits cytokine-mediated lymphocyte proliferation. Everolimus can be used as an immunosuppressant in the treatment of renal cell cancer and other cancers. Uses: Immunosuppressant. Synonyms: RAD-001; RAD001; RAD 001; Afinitor; Certican; Zortress; RAD001; SDZ-RAD. Grade: >98%. CAS No. 159351-69-6. Molecular formula: C53H83NO14. Mole weight: 958.24.
Exatecan
Exatecan is an inhibitor of DNA topoisomerase I, with an IC50 of 2.2 μM (0.975 μg/mL). It can be used to study cancer. Uses: Topoisomerase i inhibitors. Synonyms: DX-8951; (1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione; 10H,13H-Benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (1S-trans)-; NSC-829066. Grade: ≥95%. CAS No. 171335-80-1. Molecular formula: C24H22FN3O4. Mole weight: 435.45.
Exatecan Mesylate
Exatecan mesylate is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting the religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogs. Synonyms: DX 8951 mesylate; (1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione mesylate; 10H,13H-Benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (1S-trans)-, mesylate (1:1); NSC-829066 mesylate. Grade: >98%. CAS No. 169869-90-3. Molecular formula: C25H26FN3O7S. Mole weight: 531.56.
Exenatide
Exenatide, naturally occured in the saliva of the Gila monster, an incretin mimetic that has glucoregulatory effect. As a glucagon-like peptide-1 (GLP-1) receptor agonist, it stimulates proliferation of HCAECs through PKA-PI3K/Akt-eNOS activation pathways. Uses: Hypoglycemic agents. Synonyms: L-Serinamide, L-histidylglycyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-asparaginylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-; L-. CAS No. 141758-74-9. Molecular formula: C184H282N50O60S. Mole weight: 4186.56.
Exenatide acetate
Exenatide acetate is a potent peptide agonist of the glucagon-like peptide 1 (GLP-1) receptor with Ki value of 136 pM. It is a 39 amino acid peptide, which increases intracellular cAMP in pancreatic acinar cells and has no effect on VIP receptors. It was first isolated from the venom of H. horridum and consequently synthesized. It stimulates proliferation of HCAECs through PKA-PI3K/Akt-eNOS activation pathways via a GLP-1 receptor-dependent mechanism. It also stimulates glucose-induced insulin secretion in isolated rat islets and proinsulin expression in mouse insulinoma βTC-1 cells. It protects hippocampal neurons against glutamate-induced apoptosis, suggesting utility in neurodegenerative diseases. It also has anxiolytic and anti-depressant effects and induces satiety. It is an incretin mimetic approved for type 2 diabetes mellitus treatment. It also has neurotrophic/protective activity in cellular and animal models of stroke, Alzheimer's and Parkinson's diseases. Synonyms: L-Serinamide, L-histidylglycyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-asparaginylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-, ac. Grade: >9
Exendin 3 (9-39)
Exendin (9-39) is a specific and competitive glucagon-like peptide-1receptor antagonist (Kd = 1.7 nM at cloned human GLP-1 receptors). Exendin (9-39) inhibits insulin release and cAMP production caused by GLP-1 (7-36), exendin-3, and exendin-4. Synonyms: Exendin 9-39; Exendin 9 39; H-DL-Asp-DL-Leu-DL-Ser-DL-Lys-DL-Gln-DL-Met-DL-Glu-DL-Glu-DL-Glu-DL-Ala-DL-Val-DL-Arg-DL-Leu-DL-Phe-DL-xiIle-DL-Glu-DL-Trp-DL-Leu-DL-Lys-DL-Asn-Gly-Gly-DL-Pro-DL-Ser-DL-Ser-Gly-DL-Ala-DL-Pro-DL-Pro-DL-Pro-DL-Ser-NH2; DL-alpha-aspartyl-DL-leucyl-DL-seryl-DL-lysyl-DL-glutaminyl-DL-methionyl-DL-alpha-glutamyl-DL-alpha-glutamyl-DL-alpha-glutamyl-DL-alanyl-DL-valyl-DL-arginyl-DL-leucyl-DL-phenylalanyl-DL-isoleucyl-DL-alpha-glutamyl-DL-tryptophyl-DL-leucyl-DL-lysyl-DL-asparagyl-glycyl-glycyl-DL-prolyl-DL-seryl-DL-seryl-glycyl-DL-alanyl-DL-prolyl-DL-prolyl-DL-prolyl-DL-serinamide. Grade: ≥95%. CAS No. 133514-43-9. Molecular formula: C149H234N40O47S. Mole weight: 3369.76.