BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
BIM 23042 is a selective neuromedin B receptor (NMB-R, BB1) antagonist (Ki = 216 and 18, 264 nM for BB1 and BB2 receptors, respectively) displaying no effect on a range of other receptors. Synonyms: H-D-2-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-2-NAL-NH2; BIM 23042. CAS No. 111857-96-6. Molecular formula: C62H73N11O9S2. Mole weight: 1180.44.
Dabrafenib
Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively. Uses: Antineoplastic agents. Synonyms: N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-benzenesulfonamide; Dabarefenib; GSK 2118436; Tafinlar. Grade: >98%. CAS No. 1195765-45-7. Molecular formula: C23H20F3N5O2S2. Mole weight: 519.56.
DADLE
DADLE is a prototypical δ-opioid receptor agonist with antinociceptive activity. It also exhibits activity at the μ-opioid receptor. Synonyms: [D-Ala2,D-Leu5]-Enkephalin. Grade: >95%. CAS No. 63631-40-3. Molecular formula: C29H39N5O7. Mole weight: 569.65.
[D-Ala2]-GIP (human)
A highly potent GIP receptor agonist (EC50 = 630 ± 119 pM). Displays equivalent cAMP stimulating properties and improved resistance to enzymatic degradation compared to native GIP in cells expressing wild type GIP receptor. Improves glucose tolerance, insulin release and cognitive function in various animal models of obesity and diabetes. Displays neuroprotective effects in an MPTP model of PD. Synonyms: (D-Ala2)-Gastric Inhibitory Polypeptide (human); H-Tyr-D-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln-OH; L-tyrosyl-D-alanyl-L-alpha-glutamyl-glycyl-L-threonyl-L-phenylalanyl-L-isoleucyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-isoleucyl-L-alanyl-L-methionyl-L-alpha-aspartyl-L-lysyl-L-isoleucyl-L-histidyl-L-glutaminyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-asparagyl-L-tryptophyl-L-leucyl-L-leucyl-L-alanyl-L-glutaminyl-L-lysyl-glycyl-L-lysyl-L-lysyl-L-asparagyl-L-alpha-aspartyl-L-tryptophyl-L-lysyl-L-histidyl-L-asparagyl-L-isoleucyl-L-threonyl-L-glutamine. Grade: ≥98% by HPLC. CAS No. 444073-04-5. Molecular formula: C226H338N60O66S. Mole weight: 4983.53.
[D-Ala2]-Leucine enkephalin
[D-Ala2]-Leucine enkephalin is a delta opioid agonist used to study the signaling pathway of delta opioid receptors. It inhibits the release of acetylcholine and inhibits muscle contraction. Synonyms: L-Leucine, N-[N-[N-(N-L-tyrosyl-D-alanyl)glycyl]-L-phenylalanyl]-; L-Tyrosyl-D-alanylglycyl-L-phenylalanyl-L-leucine; 1-5-(D-Ala2)-dynorphin; 2-D-Alanine-5-leucine-enkephalin; [D-Ala2]leucine-enkephalin; H-Tyr-D-Ala-Gly-Phe-Leu-OH; Leuphasyl; NSC 374895; Pentapeptide 18; Tyr-D-Ala-Gly-Phe-Leu; Tyr-D-Ala-Gly-Phe-Leu-OH; Tyrosyl-D-alanylglycylphenylalanylleucine. CAS No. 64963-01-5. Molecular formula: C29H39N5O7. Mole weight: 569.65.
DALARGIN
Dalargin is an endogenous opioid peptide leucine-encephalin. Synonyms: (D-Ala2)-Leu-Enkephalin-Arg; H-Tyr-D-Ala-Gly-Phe-Leu-Arg-OH. Grade: 98%. CAS No. 81733-79-1. Molecular formula: C35H51N9O8. Mole weight: 725.83.
Dalbavancin
Dalbavancin is a semi-synthetic glycopeptide by introducing a positively charged lipophilic moiety in a previously unexplored region of the natural glycopeptide. This modification provides a longer in vivo half life, and improved in vitro activity against a variety of Gram-positive and multi-drug resistant isolates such as MRSA and MRSE. Synonyms: dalbavancin B0; BI397. Grade: >98%. CAS No. 171500-79-1. Molecular formula: C88H100Cl2N10O28. Mole weight: 1816.69.
D-allo-Thr(6)-Octreotide
D-allo-Thr(6)-Octreotide is an impurity of Octreotide, which is a synthetic long-acting cyclic octapeptide used as a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Synonyms: DPhe-Cys-Phe-DTrp-Lys-DaThr-Cys-Thr-ol(Cys2&Cys7 bridge); [6-D-allothreonine]octreotide; DPhe-CF-DTrp-K-DaThr-C-Thr-ol(Cys2&Cys7 bridge); Octreotide EP Impurity A; (D-Phe)-Cys-Phe-(D-Trp)-Lys-(Dallo-Thr)-Cys-Thr-Ol (Disulfide bond Cys2/Cys7); D-Phenylalanyl-L-cystyl-L-phenylalanyl-D-tryptophyl-L-lysyl-D-allo-threonyl-L-cystyl-L-threoninol (Disulfide Bridge between Cys2-Cys7); D-Phe-Cys-Phe-D-Trp-Lys-D-allo-Thr-Cys-Thr-ol (Disulfide Bridge between Cys2-Cys7); Octreotide impurity A; L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-D-allo-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, cyclic (2→7)-disulfide. Grade: ≥95%. CAS No. 1546983-12-3. Molecular formula: C49H66N10O10S2. Mole weight: 1019.25.
DAMGO
DAMGO is a highly selective peptide agonist of the μ opioid receptor. Uses: Analgesics, opioid. Synonyms: Y-d-Ala-G-Me-Phe-G-ol; L-tyrosyl-D-alanyl-glycyl-N-methyl-L-phenylalanyl-glycinol; DAGO; glyol; Dagol; 2-Ala-4-mephe-5-gly-enkephalin; (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin. Grade: ≥95%. CAS No. 78123-71-4. Molecular formula: C26H35N5O6. Mole weight: 513.59.
Dansyl-Glu-Gly-Arg-chloromethylketone
Dansyl-Glu-Gly-Arg-chloromethylketone, an irreversible inhibitor of plasminogen activator, Factor Xa and urokinase, allows direct monitoring of labeled enzyme interactions. Uses: Fluorescent dyes. Synonyms: dansylglutamyl-glycyl-arginine chloromethyl ketone; Dns-EGR-CMK; 1,5-Dansyl-L-glutamylglycyl-L-arginine chloromethyl ketone; Dns-Glu-Gly-Arg chloromethyl ketone; Glycinamide, N-((5-(dimethylamino)-1-naphthalenyl)sulfonyl)-L-alpha-glutamyl-N-(4-((aminoiminomethyl)amino)-1-(chloroacetyl)butyl)-, (S)-. Grade: ≥95%. CAS No. 69024-84-6. Molecular formula: C26H36ClN7O7S. Mole weight: 626.13.
DAPK Substrate Peptide
Synthetic peptide substrate for death associated protein kinase (DAPK) (Km = 9 μM). Synonyms: AKOS024456611. CAS No. 386769-53-5. Molecular formula: C70H115N25O17. Mole weight: 1578.82.
Daptomycin
Daptomycin is a lipopeptide antibiotic produced by the soil saprotroph Streptomyces roseosporus. It is used to treat systemic infections and life-threatening infections caused by gram-positive organisms. Uses: Anti-bacterial agents. Synonyms: LY 146032; LY-146032; LY146032; Cidecin; Cubicin. Grade: >95%. CAS No. 103060-53-3. Molecular formula: C72H101N17O26. Mole weight: 1620.69.
(D-Arg0,Hyp3,Igl5,D-Igl7,Oic8)-Bradykinin
(D-Arg0,Hyp3,Igl5,D-Igl7,Oic8)-Bradykinin, a bradykinin antagonist, shows high affinity for both BK receptors. Uses: Bradykinin receptor antagonists. Synonyms: B9430; H-D-Arg-Arg-Pro-Hyp-Gly-Gly(indan-2-yl)-Ser-D-Gly(indan-2-yl)-Oic-Arg-OH; (N-(D-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolyl-glycyl-2-indan-2-yl-L-glycyl-L-seryl-2-indan-2-yl-D-glycyl)-(2S,3aS,7aS)-octahydroindole-2-carbonyl)-L-arginine; H-D-Arg-Arg-Pro-Hyp-Gly-Igl-Ser-D-Igl-Oic-Arg-OH; L-Arginine, D-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-(2S)-2-(2,3-dihydro-1H-inden-2-yl)glycyl-L-seryl-(2R)-2-(2,3-dihydro-1H-inden-2-yl)glycyl-(2S,3aS,7aS)-octahydro-1H-indole-2-carbonyl-. Grade: ≥95%. CAS No. 180981-09-3. Molecular formula: C64H95N19O13. Mole weight: 1338.56.
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is a broad spectrum neuropeptide inverse agonist and antagonist. It acts as a full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM) and antagonist at tachykinin, bradykinin, CCK and bombesin receptors. It induces apoptosis and inhibits cancer cell growth in vitro. Synonyms: 1-Arg-5-Phe-7,9-Trp-11-Leu-substance P; D-Arg(10)-D-Phe(5)-D-Trp(7,9)-Leu(11)-SP; substance P, phenylalanyl(5)-tryptophyl(7,9)-leucine(11)-. CAS No. 96736-12-8. Molecular formula: C79H109N19O12. Mole weight: 1516.85.
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate is a broad-spectrum neuropeptide inverse agonist and antagonist. It acts as a full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM) and antagonist at tachykinin, bradykinin, CCK, and bombesin receptors. It induces apoptosis and inhibits cancer cell growth in vitro. Synonyms: H-D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2.CH3CO2H; D-arginyl-L-prolyl-L-lysyl-L-prolyl-D-phenylalanyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl-L-leucinamide acetic acid; [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P acetate. Grade: ≥95%. CAS No. 2918771-49-8. Molecular formula: C81H113N19O14. Mole weight: 1576.91.
(D-ARG1,D-PRO2,D-TRP7,9,LEU11)-SUBSTANCE P
It is a potent antagonist for substance P and bombesin. Synonyms: Substance P, arg(1)-pro(2)-trp(7),(9)-leunh(2)(11)-; Argininyl(1)-prolyl(2)-tryptophyl-7,9-leucinamide(11)-substance P. CAS No. 84676-91-5. Molecular formula: C75H108N20O13. Mole weight: 1497.79.
Dasiglucagon acetate
Dasiglucagon acetate is a glucagon analog for diabetic hypoglycemic treatment, which has a higher absorption rate and longer plasma elimination half-life than conventional reconstituted glucagon. Synonyms: H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Aib-Ala-Arg-Ala-Glu-Glu-Phe-Val-Lys-Trp-Leu-Glu-Ser-Thr-OH.CH3CO2H; L-histidyl-L-seryl-L-glutaminyl-glycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-alpha-methyl-alanyl-L-alanyl-L-arginyl-L-alanyl-L-alpha-glutamyl-L-alpha-glutamyl-L-phenylalanyl-L-valyl-L-lysyl-L-tryptophyl-L-leucyl-L-alpha-glutamyl-L-seryl-L-threonine acetic acid. Grade: ≥95%. Molecular formula: C154H226N38O52. Mole weight: 3441.67.
D-Aspartic acid
D-Aspartic acid is a kind of non-essential amino acid found in food sources and dietary supplements. It is an endogenous NMDA receptor agonist and has similar activity to the L-isomer. It is also a non-metabolizable substrate for EAA uptake systems. It adjusts melatonin synthesis in the pineal gland. It may be used as a therapeutic agent in the treatment of schizophrenia-related symptoms. Synonyms: (-)-Aspartic Acid; (R)-Aspartic Acid; D-(-)-Aspartic Acid; 2-Aminobutanedioic Acid; NSC 97922; NSC97922; NSC-97922; (R)-(-)-Aminosuccinic acid; (R)-2-Aminosuccinic acid; D-Aminosuccinic acid. Grade: 97%. CAS No. 1783-96-6. Molecular formula: C4H7NO4. Mole weight: 133.10.
Daunorubicin
Daunomycin is an anthracycline antibiotic produced by Streptomyces peucetius. The mechanism of action is the same as that of doxorubicin, which is inserted into DNA and inhibits RNA and DNA synthesis. It is mainly used for the treatment of acute myeloid and lymphocytic leukemia, with adverse reactions such as cardiotoxicity and bone marrow suppression. It has anti-gram-positive bacteria, negative bacteria and tumor activity. Uses: Adcs cytotoxin. Synonyms: Doxorubicin EP Impurity A; (8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione; Daunomycin; Acetyladriamycin; Leukaemomycin C; Cerubidine; Rubidomycin; (1S,3S)-3-Acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl-3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside; NSC 82151; (8S-cis)-8-Acetyl-10-((3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione; Epirubicin EP Impurity D; Rubomycin C. Grade: 95%. CAS No. 20830-81-3. Molecular formula: C27H29NO10. Mole weight: 527.52.
Daunorubicin hydrochloride
Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. Uses: Adcs cytotoxin. Synonyms: RP 13057 Hydrochloride; Daunomycin; RP13057 Hydrochloride; RP-13057 Hydrochloride; Rubidomycin hydrochloride. Grade: >98%. CAS No. 23541-50-6. Molecular formula: C27H30ClNO10. Mole weight: 563.98.
DBCO-Biotin
An intermidate used for antibody-drug conjugates. Synonyms: Azadibenzocyclooctyne-Biotin conjugate; N-[3-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-3-oxopropyl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide. CAS No. 1418217-95-4. Molecular formula: C28H30N4O3S. Mole weight: 502.63.
DBCO-NHCO-PEG12-biotin
DBCO-NHCO-PEG12-biotin is a polyethylene glycol (PEG)-based PROTAC linker. DBCO-NHCO-PEG12-biotin can be used in the synthesis of a series of PROTACs. Molecular formula: C55H83N5O16S. Mole weight: 1102.34.
DBCO-NHCO-PEG2-Biotin
DBCO-NHCO-PEG2-Biotin is a polyethylene glycol (PEG)-based PROTAC linker. DBCO-NHCO-PEG2-Biotin can be used in the synthesis of a series of PROTACs. Molecular formula: C36H45N5O6S. Mole weight: 675.84.
DBCO-NHCO-PEG6-Biotin
DBCO-NHCO-PEG6-Biotin is a polyethylene glycol (PEG)-based PROTAC linker. DBCO-NHCO-PEG6-Biotin can be used in the synthesis of a series of PROTACs. Molecular formula: C43H59N5O10S. Mole weight: 838.02.
DBCO-NH-PEG12-Biotin
DBCO-NH-PEG12-Biotin is a biotin-PEG derivative for biotinylation. The biotin group serves as an affinity label towards the proteins avidin and streptavidin. Synonyms: Azadibenzocyclooctyne-PEG12-Biotin conjugate. Grade: >95%. Molecular formula: C55H83N5O16S. Mole weight: 1102.34.
DBCO-NH-PEG2-Biotin
DBCO-NH-PEG2-Biotin is a biotin-PEG derivative for biotinylation. The biotin group serves as an affinity label towards the proteins avidin and streptavidin. Synonyms: Azadibenzocyclooctyne-PEG2-Biotin conjugate. Grade: >95%. Molecular formula: C35H43N5O6S. Mole weight: 661.81.
DBCO-NH-PEG4-biotin
DBCO-NH-PEG4-biotin is a heterobifunctional PEG linker containing a biotin group and an alkyne group. The alkyne group can react with azide in various biomolecules via click chemistry. The PEG spacer increases membrane impermeability of molecules conjugated to biotin. Synonyms: Dibenzocyclooctyne-PEG4-Biotin conjugate; DBCO-PEG4-Biotin. Grade: >95%. CAS No. 1255942-07-4. Molecular formula: C39H51N5O8S. Mole weight: 749.92.
DBCO-NH-PEG6-Biotin
DBCO-NH-PEG6-Biotin is a biotin-PEG derivative for biotinylation. The biotin group serves as an affinity label towards the proteins avidin and streptavidin. Synonyms: Azadibenzocyclooctyne-PEG6-Biotin conjugate. Grade: >95%. Molecular formula: C43H59N5O10S. Mole weight: 838.02.
DBCO-PEG3-Biotin
A biotinylation reagent containing a DBCO moiety for click chemistry. Grade: >95%. Molecular formula: C37H47N5O7S. Mole weight: 705.32.
DBCO-PEG4-Desthiobiotin
DBCO-PEG4-Desthiobiotin is a polyethylene glycol (PEG)-based PROTAC linker. DBCO-PEG4-Desthiobiotin can be used in the synthesis of a series of PROTACs. Synonyms: DBCO-PEG4-Desthiobiotin; 2032788-37-5; AKOS040743203; BP-22451; HY-140301; CS-0114730; N-[2-[2-[2-[2-[3-[[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethyl]-6-[(4R,5S)-5-methyl-2-oxoimidazolidin-4-yl]hexanamide. CAS No. 2032788-37-5. Molecular formula: C39H53N5O8. Mole weight: 719.87.
DBCO-S-S-PEG3-biotin
DBCO-S-S-PEG3-biotin is a polyethylene glycol (PEG)-based PROTAC linker. DBCO-S-S-PEG3-biotin can be used in the synthesis of a series of PROTACs. Synonyms: Azadibenzocyclooctyne-S-S-PEG3-biotin conjugate. Grade: >99%. CAS No. 1430408-09-5. Molecular formula: C42H56N6O8S3. Mole weight: 869.12.
(d(CH2)51,D-Tyr(Et)2,Val4,Arg8,des-Gly9)-Vasopressin is an antagonist of both the antidiuretic and vasopressor responses of vasopressin. Uses: Hormone antagonists. Synonyms: LS-186846; Mcp-tva-argipressin; SKF 101926; β-Mercapto-β,β-cyclopentamethylene-propionyl-D-Tyr(Et)-Phe-Val-Asn-Cys-Pro-Arg-NH2 (Disulfide bond); d(CH2)5[Tyr(Et)2,Val4,des-Gly9]AVP; 1-((β-Mercapto-β)β-cyclopentamethylenepropionic acid)-2-(O-ethyl-tyr)-4-val-9-des-gly-arginine vasopressin; 1-{[(10R,13S,16S,19S,22R)-13-(2-Amino-2-oxoethyl)-19-benzyl-22-(4-ethoxybenzyl)-16-isopropyl-12,15,18,21,24-pentaoxo-7,8-dithia-11,14,17,20,23-pentaazaspiro[5.19]pentacos-10-yl]carbonyl}-L-prolyl-N5-(diaminomethylene)-L-ornithinamide; N-[[1-Mercapto(1)-cyclohexyl]acetyl]-O-ethyl-D-Tyr-L-Phe-L-Val-L-Asn-L-Cys(1)-L-Pro-L-Arg-NH2; O-Ethyl-N-[1-mercapto(1)cyclohexylacetyl]-D-Tyr-L-Phe-L-Val-L-Asn-L-Cys(1)-L-Pro-L-Arg-NH2; (d(CH2)51,D-Tyr(Et)2,Val4,Arg8,des-Gly9)-Vasopressin. Grade: 95%. CAS No. 90332-82-4. Molecular formula: C51H74N12O10S2. Mole weight: 1079.34.
(d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin
(d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin is a potent oxytocin antagonist with a pA2 of 7.35±0.08. It has been used to support the hypothesis that pituitary secretion of oxytocin is associated with coactivation of centrally projecting brain oxytocin pathways, some of which are causally associated with induced inhibition of food intake. In addition, it competitively inhibits the contraction of arginine vasotocin (AVT) without affecting the efficacy of AVT. Synonyms: [Pmp1,Tyr(OMe)2,Orn8] Vasotocin; β-Mercapto-β,β-cyclopentamethylene-propionyl-Tyr(Me)-Ile-Gln-Asn-Cys-Pro-Orn-Gly-NH2 (Disulfide bond); [beta-Mercapto-beta,beta-cyclopentamethylenepropionyl1,O-Me-Tyr2,Orn8]-Oxytocin; 1-{[(10R,13S,16S,19S,22S)-13-(2-Amino-2-oxoethyl)-16-(3-amino-3-oxopropyl)-19-[(2S)-2-butanyl]-22-(4-methoxybenzyl)-12,15,18,21,24-pentaoxo-7,8-dithia-11,14,17,20,23-pentaazaspiro[5.19]pentacos-10-yl]carbonyl}-L-prolyl-L-ornithylglycinamide; (d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin. Grade: ≥90% by HPLC. CAS No. 77327-45-8. Molecular formula: C48H74N12O12S2. Mole weight: 1075.32.
D-Cycloserine
It is produced by the strain of Streptomyces orchidaceus, Str. lavendulae, Str. roseochromogenes. It can inhibit bacterial alanine racase, D-alanyl-D-alanine synthetase, and interfere with cell wall biosynthesis. Its antibacterial spectrum is wide, and it has activity against gram-positive bacteria, negative bacteria, mycobacterium, rickettsia and amoeba of dysentery. It is now used as a second-line anti-tuberculosis drug. Uses: Anti-infective agents, urinary; antibiotics, antitubercular; antimetabolites. Synonyms: Oxamycin; Antibiotic PA-94; JN-21; Seromycin; orientomycin; Cyclo-D-serine; Cyclorin; D-4-amino-3-isoxazolidinone; Cicloserina; Farmiserina; Miroseryn; alpha-Cycloserine; (+)-4-Amino-3-isoxazolidinone; (+)-Cycloserine; (R)-(+)-Cycloserine; (R)-4-Amino-3-isoxazolidinone; (R)-Cycloserine. Grade: ≥ 97% by HPLC. CAS No. 68-41-7. Molecular formula: C3H6N2O2. Mole weight: 102.09.
D-Cysteine
D-Cysteine is a strong inhibitor of Escherichia coli growth and also functions to provide inorganic sulfates for the sulfation of xenobiotics. D-Cysteine is a non-physiological isomer of L-Cysteine, and is not involved in protein or glutathione synthesis. Synonyms: (S)-Cysteine; (S)-2-amino-3-mercaptopropanoic acid; D-Zystein; D-Amino-3-mercaptopropionic acid; D-Cys; (2S)-2-amino-3-mercaptopropanoic acid. Grade: ≥97%. CAS No. 921-01-7. Molecular formula: C3H7NO2S. Mole weight: 121.16.
Dde Biotin-PEG4-alkyne is a polyethylene glycol (PEG)-based PROTAC linker. Dde Biotin-PEG4-alkyne can be used in the synthesis of a series of PROTACs. CAS No. 1802908-00-4. Molecular formula: C32H50N4O8S. Mole weight: 650.83.
Dde Biotin-PEG4-azide
Dde Biotin-PEG4-azide is useful for introducing a biotin moiety to alkyne-containing biomolecules using Cu(I)-catalyzed Click Chemistry. The hydrophilic spacer arm provides better solubility to the labeled molecules in aqueous media. Dde protecting group allows efficient release of captured biotinylated molecules from streptavidin under mild conditions with hydrazine. Please contact us for GMP-grade inquiries. Synonyms: Dde Biotin-PEG4-Azide; 1802907-93-2; Dde Biotin Azide; AKOS040741615; BP-22678. Grade: 0.95. CAS No. 1802907-93-2. Molecular formula: C32H53N7O8S. Mole weight: 695.9.
Dde Biotin-PEG4-DBCO
Dde Biotin-PEG4-DBCO is a polyethylene glycol (PEG)-based PROTAC linker. Dde Biotin-PEG4-DBCO can be used in the synthesis of a series of PROTACs. CAS No. 1807512-43-1. Molecular formula: C47H61N5O9S. Mole weight: 872.08.
Dde Biotin-PEG4-Picolyl azide
Dde Biotin-PEG4-Picolyl azide is a polyethylene glycol (PEG)-based PROTAC linker. Dde Biotin-PEG4-Picolyl azide can be used in the synthesis of a series of PROTACs. CAS No. 2055048-42-3. Molecular formula: C38H57N9O9S. Mole weight: 815.98.
D-Desthiobiotin
D-Desthiobiotin is an analogue of Biotin and a protein cross-linking agent. It is used in the preparation of agarose matrices for affinity-based isolation of streptavidin-fluorophore conjugates. Synonyms: Desthiobiotin; Dethiobiotin; d-Dethiobiotin; (+)-Dethiobiotin; ε-(4-Methyl-5-imidazolidone-2)caproic Acid; (4R,5S)-5-Methyl-2-oxo-4-imidazolidinehexanoic Acid; (4R-cis)-5-methyl-2-oxo-4-Imidazolidinehexanoic Acid; 4-Methyl-5-(ω-carboxyamyl)imidazolidone; 5-Methyl-2-oxo-4-imidazolidinecaproic Acid. Grade: ≥95% by HPLC. CAS No. 533-48-2. Molecular formula: C10H18N2O3. Mole weight: 214.26.
D-Desthiobiotin-7-dATP
D-Desthiobiotin-7-dATP is a vital component in biomedical research, widely used for DNA labeling and sequencing applications. It serves as a high-affinity substrate for certain DNA polymerases and DNA-modifying enzymes. This product aids in the study of DNA-protein interactions. Synonyms: N6-(6-Amino)hexyl-dATP - D-Desthiobiotin; N6-(6-Amino)hexyl-2'-deoxyadenosine-5'-triphosphate - D-Desthiobiotin, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C26H45N8O14P3. Mole weight: 786.6.
Dde TAMRA Biotin Alkyne
Dde TAMRA Biotin Alkyne is a trifunctional, cleavable probe that allows for efficient recovery of avidin-bound protein complexes in affinity-based assays. This reagent contains a fluorescent dye (TAMRA) and biotin moiety linked to azide group through a spacer arm containing a hydrazine-cleavable Dde moiety. Under mild conditions (2% aqueous hydrazine), the Dde liner is cleaved, releasing the biotin tag and any avidin conjugate bound to it. CAS No. 2353409-55-7. Molecular formula: C72H100N9O18S. Mole weight: 1411.7.
Deacetylanisomycin
It is an antitumor antibiotic produced by the strain of Streptomyces SA 3097. It is an effective inhibitor of protein synthesis and plant growth regulator. Synonyms: (-)-Deacetylanisomycin; 3,4-Pyrrolidinediol, 2-(p-methoxybenzyl)-, (2R,3S,4S)-(-)-; Antibiotic SA 3097D1. Grade: >99% by HPLC. CAS No. 27958-06-1. Molecular formula: C12H17NO3. Mole weight: 223.27.
Deacetylravidomycin
Deacetyiravidomycin is an antibiotic produced by Streptomyces sp. WK-6326. It has anti-Gram-positive bacteria activity with a MIC of 3.0-5.0 μg/mL. Synonyms: Desacetylravidomycin; 6H-Benzo(d)naphtho(1,2-b)pyran-6-one, 4-(3,6-dideoxy-3-(dimethylamino)-alpha-altopyranosyl)-10,12-dimethoxy-8-ethenyl-1-hydroxy-. Grade: >95% by HPLC. CAS No. 88580-27-2. Molecular formula: C29H31NO8. Mole weight: 521.56.
(Deamino-Cys1,Arg8)-Vasopressin
(Deamino-Cys1,Arg8)-Vasopressin is used to treat diabetes insipidus, bedwetting, hemophilia A, von Willebrand disease, and high blood urea levels. Synonyms: Mpr-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2(Mpr1&Cys6 bridge); Mpr-YFQNCPRG-NH2(Mpr1&Cys6 bridge); [8-L-arginine]desmopressin; Desmopressin EP Impurity D; deamino-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge: Cys1-Cys6); Deamino-cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparagyl-L-cysteinyl-L-prolyl-L-arginyl-glycinamide (1->6)-disulfide; [Arg8]-Desmopressin; Arg(8)-Desmopressin; [L-Arg8]-Desmopressin; Arg8-Desmopressin; 3-Mercaptopropionyl-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge: Cys1-Cys6); Glycinamide, N-(3-mercapto-1-oxopropyl)-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-arginyl-, cyclic (1→5)-disulfide; Vasopressin, 1-(3-mercaptopropanoic acid)-8-L-arginine-; 1-Deamino-8-L-arginine-vasopressin; 1-Desamino-L-arginine vasopressin; 8-Arginine-deaminovasopressin; [1-β-Mercaptopropionic acid,8-arginine]vasopressin; DAVP; Desamino-Arg8-vasopressin. Grade: ≥90%. CAS No. 113-81-5. Molecular formula: C46H64N14O12S2. Mole weight: 1069.22.
(Deamino-Cys1,Val4,D-Arg8)-Vasopressin
(Deamino-Cys1,Val4,D-Arg8)-Vasopressin is a highly effective and long-lasting antidiuretic agonist with virtually no vasopressor activity. Synonyms: (Val4)-Desmopressin; deamino-cysteinyl-L-tyrosyl-L-phenylalanyl-L-valyl-L-asparagyl-L-cysteinyl-L-prolyl-D-arginyl-glycinamide (1->6)-disulfide; 3-Mercaptopropionyl-Tyr-Phe-Val-Asn-Cys-Pro-D-Arg-Gly-NH2 (Disulfide bridge: Cys1-Cys6); deamino-Cys(1)-Tyr-Phe-Val-Asn-Cys(1)-Pro-D-Arg-Gly-NH2; 1-deamino-4-Val-8-Arg-vasopressin; (1-deamino,4-valine)-8-D-argininevasopressin. Grade: ≥95% by HPLC. CAS No. 43157-23-9. Molecular formula: C46H65N13O11S2. Mole weight: 1040.22.
(Deamino-Phe19,D-Ala24,D-Pro26-(R)-Phe27)-GRP (19-27) (human, porcine, canine) is a bombesin receptor antagonist, which can effectively inhibit bombesin-evoked release of gastrointestinal hormones in vivo and in vitro in rats and dogs. Synonyms: BW-10; Deamino-Phe-His-Trp-Ala-Val-D-Ala-His-D-Pro-psi(CH2NH)Phe-NH2; (Deamino-Phe19,D-Ala24,D-Pro26-psi(CH2NH)Phe27)-GRP (19-27) (human, porcine, canine); ((des-NH2)Phe(19)-D-Ala(24)-D-Pro(26)psi(CH2NH)Phe(27))-GRP(19-27); GRP (19-27), (de-NH2)Phe(19)-Ala(24)-Pro(26)psi(CH2NH)Phe(27)-; GRP (19-27), (de-NH2)phenylalanyl(19)-alanyl(24)-prolyl(26)psi(CH2NH)-phenylalanine(27)-; Nα-({(2R)-1-[N-(3-Phenylpropanoyl)-L-histidyl-L-tryptophyl-L-alanyl-L-valyl-D-alanyl-L-histidyl]-2-pyrrolidinyl}methyl)-L-phenylalaninamide; BW2258U89. Grade: 95%. CAS No. 142061-53-8. Molecular formula: C57H72N14O8. Mole weight: 1081.27.
Decanoyl-RVKR-CMK
Decanoyl-RVKR-CMK is a proprotein convertase inhibitor and has been found to restrain regulated secretion of the neuronal polypeptide VGF in PC12 cells. Synonyms: Decanoyl-Arg-Val-Lys-Arg-CMK; N2-(1-Oxodecyl)-L-arginyl-L-valyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-L-lysinamide. Grade: >98%. CAS No. 150113-99-8. Molecular formula: C34H66ClN11O5. Mole weight: 744.42.
DecarboxyBiotin-Alkyne
DecarboxyBiotin-Alkyne is a click chemistry reagent. CAS No. 887915-53-9. Molecular formula: C12H18N2OS. Mole weight: 238.35.
Decatromicin B
Decatromicin B is an antibiotic produced by Actinomadura sp. MK73-NF4. Decatromicin B has anti-gram-positive bacteria activity. Grade: >95% by HPLC. CAS No. 235097-64-0. Molecular formula: C45H56Cl2N2O10. Mole weight: 855.84.
Decladinose Roxithromycin
An impurity found in the macrolide antibiotic, Roxithromycin. Synonyms: 3-O-de(2,6-dideoxy-3-C-methyl-3-O-methyl-α-Lribo-hexopyranosyl)erythromycin 9-(E)-[O-[(2-methoxyethoxy)methyl]oxime]; Decladinosylroxithromycin; Roxithromycin Impurity B; (9E)-3-O-de(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)erythromycin9-[O-[(2-Methoxyethoxy)methyl]oxime]. Grade: >95%. CAS No. 214902-82-6. Molecular formula: C33H62N2O12. Mole weight: 678.85.
Degarelix
Degarelix acetate is a reversible gonadotropin-releasing hormone receptor (GnRHR) antagonist. Degarelix reduces the secretion of luteinizing hormone (LH) and testosterone via blocking GnRHR. Degarelix can be used for the treatment of prostate cancer. Synonyms: Degarelix; Firmagon; FE-200486; FE 200486; FE200486; ASP-3550; ASP 3550; ASP3550; Ac-D-2Nal-D-Phe(4-Cl)-D-3Pal-Ser-Phe(4-S-dihydroorotamido)-D-Phe(4-ureido)-Leu-Lys(iPr)-Pro-D-Ala-NH2. Grade: >98%. CAS No. 214766-78-6. Molecular formula: C82H103ClN18O16. Mole weight: 1632.286.
Degarelix acetate
Degarelix is a synthetic gonadotropin-releasing hormone receptor (GNRHR) antagonist. It decreases tumor volume of Dunning R3327H prostate tumor flank implants in rats when administered at a dose of 1 mg/kg per month. Formulations containing degarelix have been used in the treatment of advanced prostate cancer. Synonyms: Ac-D-2Nal-D-Phe(4-Cl)-D-3Pal-Ser-Phe(4-S-dihydroorotamido)-D-Phe(4-ureido)-Leu-Lys(iPr)-Pro-D-Ala-NH2.CH3CO2H; N-acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-4-((S)-dihydroorotamido)-L-phenylalanyl-4-ureido-D-phenylalanyl-L-leucyl-N6-isopropyl-L-lysyl-L-prolyl-D-alaninamide acetic acid; D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-4-[[[(4S)-hexahydro-2,6-dioxo-4-pyrimidinyl]carbonyl]amino]-L-phenylalanyl-4-[(aminocarbonyl)amino]-D-phenylalanyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl-, acetate (1:1); FE 200486; Gonax. Grade: ≥98%. CAS No. 934016-19-0. Molecular formula: C82H103ClN18O16.C2H4O2. Mole weight: 1692.31.
Degarelix acetate hydrate
Degarelix acetate is a synthetic peptide that acts as a gonadotrophin-releasing hormone (GnRH) antagonist. Degarelix targets GnRH receptors in the pituitary gland, resulting in reduction of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and suppression of testosterone. Synonyms: FE-200486; FE 200486; FE200486; ASP-3550; ASP 3550; ASP3550. CAS No. 934246-14-7. Molecular formula: C84H109ClN18O19. Mole weight: 1710.32.
delta2-Avermectin B1a
Δ2-Avermectin B1a is a degradation product produced by the reversible base-catalyzed isomerization of ivermectin B1a. It is less active than ivermectin against T. urticae (LC90s = 0.23 and 0.038 ppm, respectively). Synonyms: Avermectin A1a, 2,3-didehydro-5-O-demethyl-3,4-dihydro-, (4S)-; Δ2-4(R)-avermectin B1a; Δ2-Avermectin B1a. Grade: >95% by HPLC. CAS No. 110415-68-4. Molecular formula: C48H72O14. Mole weight: 873.07.
Delta-2-Ivermectin B1a
An irreversible base degradation product of ivermectin found in animals treated with ivermectin and in the environment. It is an anthelmintic in animal health. Synonyms: Δ2-Ivermectin B1a; Ivermectin B1a, delta2-. Grade: >95% by HPLC. Molecular formula: C48H74O14. Mole weight: 875.09.
Deltorphin
Deltorphin is a naturally occurring, exogenous opioid heptapeptide. Synonyms: L-α-Asparagine, L-tyrosyl-D-methionyl-L-phenylalanyl-L-histidyl-L-leucyl-L-methionyl-; L-Tyrosyl-D-methionyl-L-phenylalanyl-L-histidyl-L-leucyl-L-methionyl-L-α-asparagine; Deltorphin A; Dermenkephalin; H-Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2. Grade: 95%. CAS No. 119975-64-3. Molecular formula: C44H62N10O10S2. Mole weight: 955.15.
Deltorphin 2
Deltorphin 2, an anion transporting peptid, is a selective peptide agonist for theδ opioid receptor. Synonyms: Deltorphin II; Deltorphin B; H-Tyr-D-Ala-Phe-Glu-Val-Val-Gly-NH2; L-tyrosyl-D-alanyl-L-phenylalanyl-L-alpha-glutamyl-L-valyl-L-valyl-glycinamide. CAS No. 122752-16-3. Molecular formula: C38H54N8O10. Mole weight: 782.88.
DELTORPHIN I
Deltorphin I has been found to be an effective δ opioid agonist. Synonyms: L-Tyrosyl-D-alanyl-L-phenylalanyl-L-α-aspartyl-L-valyl-L-valylglycinamide. Grade: ≥95% by HPLC. CAS No. 122752-15-2. Molecular formula: C37H52N8O10. Mole weight: 768.87.
Demeclocycline
It is produced by the strain of Streptomuces aureofaciens var. 38-2-14. It shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal subunits, blocking protein synthesis. Synonyms: Demethylchlortetracycline; 6-Demethylchlotetracycline; DMCT; 7-Chloro-6-demethyltetracycline; Ledermycin; RP 10192; Antibiotic 38-2-14 A; Novotriclina; Perciclina; Sumaclina. Grade: >98% by HPLC. CAS No. 127-33-3. Molecular formula: C21H21ClN2O8. Mole weight: 464.85.
Demeclocycline hydrochloride
Demethylchlorotetracycline is an antibiotic produced by Streptomyces viridifaciens and Str. aureofaciens S-604. It has antibacterial and anti-insect activity. Synonyms: Demethylchlortetracycline hydrochloride; Demethylchlorotetracycline hydrochloride. Grade: >98% by HPLC. CAS No. 64-73-3. Molecular formula: C21H22Cl2N2O8. Mole weight: 501.31.
Demecycline
Demecycline is a tetracycline antibiotic produced by the strain of Streptomyces aureofaciens var. 38-2-14 that is a C6-demethylated derivative of tetracycline and is used to treat bacterial infections including pneumonia and other respiratory tract infections. Synonyms: 6-Demethyltetracycline; Antibiotic 38-2-14 B; Demethyltetracycline; Antibiotic RP-6798; Demeclocycline EP impurity A; (4S-(4a,4aa,5aa,6b,12aa))-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide. Grade: ≥95%. CAS No. 987-02-0. Molecular formula: C21H22N2O8. Mole weight: 430.41.
Demethylbleomycin A2 sulfate
A demethylated form of bleomycin A2 which is a major component in standard grade bleomycin. It is formed by heating bleomycin A2. It has high antimicrobial activity against mycobacterium smegmatis compared to bleomycin A2. It has a lower toxicity. Synonyms: Bleomycin DM-A2 sulfate; N1-[3-(Methylthio)propyl]bleomycinamide sulfate. Grade: ≥90%. Molecular formula: C54H81N17O21S3.xH2SO4. Mole weight: 1400.51 (free base).
Demoxytocin
Demoxytocin, a heterodetic cyclic peptide, is the synthetic analog of the peptide hormone oxytocin with prolonged activity. Synonyms: dOT; (Deamino-Cys1)-Oxytocin; 3-Mercaptopropionyl-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (Disulfide bridge: Cys1-Cys6); deamino-Cys(1)-Tyr-Ile-Gln-Asn-Cys(1)-Pro-Leu-Gly-NH2; deamino-cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparagyl-L-cysteinyl-L-prolyl-L-leucyl-glycinamide (1->6)-disulfide; Sandopart; desaminooxytocin; Demossitocina; 1-(3-Mercaptopropionic acid)-oxytocin. Grade: ≥90%. CAS No. 113-78-0. Molecular formula: C43H65N11O12S2. Mole weight: 992.18.
Dendroaspis Natriuretic Peptide
Dendroaspis Natriuretic Peptide, a 38-amino acid peptide originally isolated from the venom of the green mamba snake (Dendroaspis angusticeps), is structurally homologous to the natriuretic peptide family. It contains a 17-amino acid disulfide ring similar to ANP, BNP and CNP that mediate biological action through particulate guanylyl cyclase receptors and generation of guanosine monophosphate (cGMP). Synonyms: DNP; H-Glu-Val-Lys-Tyr-Asp-Pro-Cys-Phe-Gly-His-Lys-Ile-Asp-Arg-Ile-Asn-His-Val-Ser-Asn-Leu-Gly-Cys-Pro-Ser-Leu-Arg-Asp-Pro-Arg-Pro-Asn-Ala-Pro-Ser-Thr-Ser-Ala-OH (Disulfide bridge: Cys7-Cys23); L-alpha-Glutamyl-L-valyl-L-lysyl-L-tyrosyl-L-alpha-aspartyl-L-prolyl-L-cysteinyl-L-phenylalanylglycyl-L-histidyl-L-lysyl-L-isoleucyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-L-asparaginyl-L-histidyl-L-valyl-L-seryl-L-asparaginyl-L-leucylglycyl-L-cysteinyl-L-prolyl-L-seryl-L-leucyl-L-arginyl-L-alpha-aspartyl-L-prolyl-L-arginyl-L-prolyl-L-asparaginyl-L-alanyl-L-prolyl-L-seryl-L-threonyl-L-seryl-L-alaninecyclic(7-23)-disulfide. Grade: ≥95% by HPLC. CAS No. 255721-52-9. Molecular formula: C180H282N56O56S2. Mole weight: 4190.64.