BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Antimicrobial ribonuclease | Antimicrobial ribonuclease is produced by Lentinus sajor-caju. It has ribonuclease activity towards yeast tRNA and polyuracil and weak ribonuclease activity towards other polyhomoribonucleotides. Antimicrobial ribonuclease has weak deoxyribonuclease activity. It displays antimitogenic activity towards murine splenocytes and antiproliferative activity towards HepG2 hepatoma cells and L1210 leukemia cells. Antimicrobial ribonuclease also has antibacterial activity against Gram-negative bacteria P.aeruginosa and P.fluorescens, and the Gram-positive bacterium S.aureus. |  |
| Antimycin A1 | Antimycin A is a macrolide antibiotic produced by Streptomyces kitasawaensis, Str. griseus and Str. antibioticus. Antimycin A1 can inhibit atp-citrate lyase activity. Synonyms: dihydrosamidin. Grades: >98% by HPLC. CAS No. 642-15-9. Molecular formula: C28H40N2O9. Mole weight: 548.62. | |
| Antimycin A2 | Antimycin A is a macrolide antibiotic produced by Streptomyces kitasawaensis, Str. griseus and Str. antibioticus. Antimycin A2 can inhibit atp-citrate lyase activity. Synonyms: 3-(3-Formamidosalicylamido)-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl butyrate. Grades: 90%. CAS No. 27220-57-1. Molecular formula: C27H38N2O9. Mole weight: 534.60. | |
| Antimycin A3 | Antimycin A is a macrolide antibiotic produced by Streptomyces kitasawaensis, Str. griseus and Str. antibioticus. Antimycin A3 can inhibit atp-citrate lyase activity. Synonyms: Blastomycin. Grades: >98% by HPLC. CAS No. 522-70-3. Molecular formula: C26H36N2O9. Mole weight: 520.57. | |
| Antimycin A4 | Antimycin A is a macrolide antibiotic produced by Streptomyces kitasawaensis, Str. griseus and Str. antibioticus. Antimycin A4 can inhibit atp-citrate lyase activity. Synonyms: 8-Butyl-3-(3-formamido-2-hydroxybenzamido)-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl butyrate. Grades: >98% by HPLC. CAS No. 27220-59-3. Molecular formula: C25H34N2O9. Mole weight: 506.54. | |
| Antiostatin A1 | Antiostatin A1 is an antioxidant produced by Streptomyces cyaneus 2007-SV1. Molecular formula: C20H24N2O2. Mole weight: 324.42. | |
| Antioxidant 330 | Antioxidant 330 is an antioxidant that could be used in sorts of areas or materials as an stablizer. Uses: Hema can be used as an antioxidant in the polycondensation of poly(isosorbide maleate-co-succinate) and poly(isosorbide maleate) to prepare biobased based unsaturated polyester. it may also be used in the preparation of water soluble polyesters which can potentially be used as in drug delivery and industrial coatings. Synonyms: Ionox 330; 4, 4', 4''-[(2, 4, 6-Trimethyl-1, 3, 5-benzenetriyl)tris(methylene)]tris[2, 6-bis(1, 1-dimethylethyl)phenol; 1,3,5-Dimethyl-2,4,6-tris(3,5-tert-butyl-4-hydroxybenzyl)benzene; 1,3,5-Trimethyl-2,4,6-tri(3,5-di-tert-butyl-4-hydroxybenzyl)benzene; 1,3,5-Tris(3,5-di-tert-butyl-4-hydroxybenzyl)-2,4,6-trimethylbenzene; 1,3,5-Trismethyl-2,4,6-tris(3,5-tert-butyl-4-hydroxybenzyl)benzene; 2,4,6-Bis(4-hydroxy-3,5-di-tert-butylbenzyl)mesitylene; ADK Stab A 330; ADK Stab AO 330; Agidol 40; Alvinox 100; Anox 330; Anox 330TDS; Antioxidant 1330; Antioxidant 40; AO 13; AO 1330; AO 330; AO 40; AT 330; Chinox 1330; Ethanox 300; Ethanox 330; Ethyl 330; Ethyl Antioxidant 330; Good-rite 1330; Ionox 330; IR 1330; Irg 1330; Irganox 1330; Irganox 330; KY 1330; Mark AO 330; NSC 85846; Rianox 330; Seenox 326M; Songnox 1330; Yoshinox 1330. Grades: 98%. CAS No. 1709-70-2. Molecular formula: C54H78O3. Mole weight: 775.21. | |
| Antioxidant peptide A | Antioxidant peptide A is a short peptide that contains alternative aromatic or sulfur-containing amino acids. The side chain of antioxidant peptide A is thought to contribute to the strong free radical scavenging activity of the peptide in tumor cells. Synonyms: H-Pro-His-Cys-Lys-Arg-Met-OH; L-prolyl-L-histidyl-L-cysteinyl-L-lysyl-L-arginyl-L-methionine; N-[(2S,5S,8R,11S)-5-(4-Aminobutyl)-2-(3-carbamimidamidopropyl)-1,4,7,10,13-pentahydroxy-11-(1H-imidazol-5-ylmethyl)-13-[(2S)-2-pyrrolidinyl]-8-(sulfanylmethyl)-3,6,9,12-tetraazatrideca-3,6,9,12-tetraen-1-ylidene]methionine. Grades: >95%. CAS No. 159147-88-3. Molecular formula: C31H54N12O7S2. Mole weight: 770.97. | |
| Antipyrine Impurity | 4-Acetamido Antipyrine is a metabolite of Metamizol. Metabolism of Metamizol in early stages of the incubated hen's egg. Synonyms: N-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)acetamide; 4-(N-Acetylamino)antipyrine; 4-Acetylaminophenazone; Acetylaminoantipyrine; N-Acetyl-4-aminoantipyrine; N-Acetyl-4-aminophenazone; N-Antipyrinylacetamide; NSC 331807. Grades: > 95%. CAS No. 83-15-8. Molecular formula: C13H15N3O2. Mole weight: 245.28. | |
| Antitumor Compound 1 | Antitumor Compound 1 is a potent compound which comprises a new imidazopyridine having excellent antitumor activity as an active ingredient. Synonyms: MDK-6303; MDK 6303; MDK6303; Antitumor Compound 1. Grades: >98%. CAS No. 420126-30-3. Molecular formula: C18H10F6N4S. Mole weight: 428.35. | |
| Antiviral protein Y3 | The source of Antiviral protein Y3 is Pleurotus citrinopileatus. It has antiviral activity against Tobacco mosaic virus and antitumor activity against stomach cancer cells in vitro. | |
| Ant-m7GDP | Ant-m7GDP is an exceptional pharmacological compound characterized by its profound capacity to combat viral infections. This awe-inspiring compound exhibits an unparalleled proclivity for selectively targeting and disrupting the intricate guanosine triphosphate cap structures, thereby impeding the vital process of viral mRNA capping. Synonyms: 2'/3'-O-Anthraniloyl-7-methylguanosine-5'-diphosphate, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C18H22N6O12P2 (free acid). Mole weight: 576.35 (free acid). | |
| Ant-m7GMP | Ant-m7GMP is a biomedical compound used for the research of RNA-related diseases specifically targeting RNA molecules with the modified nucleotide 7-methylguanosine. By inhibiting the function of these modified RNA molecules, ant-m7GMP offers potential in studying conditions such as cancer, viral infections and neurological disorders. Synonyms: 2'/3'-O-Anthraniloyl-7-methylguanosine-5'-monophosphate, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C18H21N6O9P (free acid). Mole weight: 496.37 (free acid). | |
| Ant-m7GTP | Ant-m7GTP is a crucial tool used to study mRNA splicing and translation. It assists in investigating cellular processes and protein research. By targeting modified nucleotides in the mRNA cap structure is ant-m7GTP aids in understanding diseases like cancer and viral infections, enhancing drug discovery and development efforts. Synonyms: 2'/3'-O-Anthraniloyl-7-methylguanosine-5'-triphosphate, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C18H24N6O15P3 (free acid). Mole weight: 656.33 (free acid). | |
| Antrimycin A | Antrimycin is a peptide antibiotic produced by Streptomyces xanthocidicus MG125-CF1. Antrimycin A has anti-Mycobamrimn smegmatis (Mycobamrimn smegmatis) and human Mycobacterium tuberculosis H37 Rv activity, and also has an effect on rifampicin and capreomycin-resistant bacteria. Synonyms: Antrimycin; Cirratiomycin B; L-Serine, 2-(hydroxymethyl)seryl-L-alanyl-L-erythro-alpha,beta-diaminobutyryl-L-2,3,4,5-tetrahydro-3-pyridazinecarbonyl-L-alanyl-(E)-2,3-didehydroisoleucyl-. Grades: >98%. CAS No. 80801-26-9. Molecular formula: C28H47N9O11. Mole weight: 685.72. | |
| Antrimycin B | Antrimycin is a peptide antibiotic produced by Streptomyces xanthocidicus MG125-CF1. Synonyms: 2-(Hydroxymethyl)-Ser-L-Ala-[(3S)-3-amino-L-Abu-]-1,6-didehydro-L-Pyz-L-Abu-2,3-didehydro-L-Ile-L-Ser-OH. CAS No. 82518-60-3. Molecular formula: C29H49N9O11. Mole weight: 699.75. | |
| Antrimycin C | Antrimycin is a peptide antibiotic produced by Streptomyces xanthocidicus MG125-CF1. CAS No. 82534-66-5. Molecular formula: C30H51N9O11. Mole weight: 713.78. | |
| Anziaic acid | It is produced by the strain of Stereocaulon ramulosum. Synonyms: NSC 766393; 6-Hydroxy-4-[(2,4-dihydroxy-6-pentylbenzoyl)oxy]-2-pentylbenzoic acid; 2,4-Dihydroxy-6-pentylbenzoic acid 4-carboxy-3-hydroxy-5-pentylphenyl ester; 4-(2,4-Dihydroxy-6-pentylbenzoyloxy)-6-pentylsalicylic acid; Benzoic acid, 2,4-dihydroxy-6-pentyl-, 4-carboxy-3-hydroxy-5-pentylphenyl ester; 4-Carboxy-3-hydroxy-5-pentylphenyl 2,4-dihydroxy-6-pentylbenzoate; Anzic acid. Grades: ≥98% by HPLC. CAS No. 641-68-9. Molecular formula: C24H30O7. Mole weight: 430.49. | |
| AOD9604 | AOD 9604 is a modified fragment of human growth hormone (hGH) that is originally developed as an anti-obesity drug. AOD 9604 is formulated as the injection for weight loss, muscle building and so on. Synonyms: L-tyrosyl-L-leucyl-L-arginyl-L-isoleucyl-L-valyl-L-glutaminyl-L-cysteinyl-L-arginyl-L-seryl-L-valyl-L-alpha-glutamyl-glycyl-L-seryl-L-cysteinyl-glycyl-L-phenylalanine (7->14)-disulfide; AOD 9604; LAT 8881; L-Phenylalanine, L-tyrosyl-L-leucyl-L-arginyl-L-isoleucyl-L-valyl-L-glutaminyl-L-cysteinyl-L-arginyl-L-seryl-L-valyl-L-α-glutamylglycyl-L-seryl-L-cysteinylglycyl-, cyclic (7?14)-disulfide. CAS No. 221231-10-3. Molecular formula: C78H123N23O23S2. Mole weight: 1815.08. | |
| AOZ-[d4] | AOZ-[d4] is the labelled analogue of AOZ, which is a metabolite of Furazolidone. Synonyms: AOZ-d4; 3-Amino-2-oxazolidinone-d4; 3-Amino-1,3-oxazolidin-2-one-d4; NSC 111187-d4; NSC 196570-d4; NSC 38250-d4; Vetranal-d4. Grades: ≥97%; ≥97% atom D. CAS No. 1188331-23-8. Molecular formula: C3H2D4N2O2. Mole weight: 106.12. | |
| AP1903 | AP1903 is a lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity. Synonyms: AP1903; AP 1903; AP-1903; Rimiducid. Grades: 0.98. CAS No. 195514-63-7. Molecular formula: C78H98N4O20. Mole weight: 1411.63. | |
| AP20187 | Systemic AP20187 administration results in time-dependent LFv2IRE tyrosine phosphorylation and activation of the insulin signaling pathway in both liver and muscle of AAV-treated NOD mice. AP20187 stimulation significantly increases hepatic glycogen content and muscular glucose uptake similarly to insulin. The homodimerizer has been widely used to study signal transduction pathways (by inducing oligomerization of cell surface receptor proteins), but it can be used to induce the activity/re-localization of any protein that is affected by oligomerization. To test the role of homodimerization in kinase activation, we constructed a fusion protein consisting of the SLK catalytic domain (amino acids 1-373) and a modified FK506 binding protein, Fv (Fv-SLK 1-373). Addition of AP20187 (an analog of FK506) enhanced the homodimerization of Fv-SLK 1-373. Synonyms: AP 20187; AP-20187. Grades: >98%. CAS No. 195514-80-8. Molecular formula: C82H107N5O20. Mole weight: 1482.75. | |
| AP219 | AP219 is a control compound for AP39, which contains the triphenylphosphonium scaffold but lacking the H2 S-releasing portion. AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. Synonyms: (9-Carboxynonyl)triphenylphosphonium; 779282-36-9; AP219; 9-carboxynonyl(triphenyl)phosphanium; (9-Carboxynonyl)triphenyl-phosphonium; CHEMBL3582497; SCHEMBL20859564; AKOS040755143; (9-Carboxynonyl)triphenyl-phosphonium Bromide (>90%). Grades: ≥98%. CAS No. 779282-36-9. Molecular formula: C28H34O2P. Mole weight: 433.6. | |
| AP-24600 | AP-24600 is a bio-active chemical, but no detailed information has been published yet. Synonyms: AP-24600; AP 24600; AP24600; DA-12847; KB-310048; DA 12847; KB 310048; DA12847; KB310048; UNII-OZ477A282R; OZ477A282R;3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic acid. Grades: 98%. CAS No. 1300690-48-5. Molecular formula: C16H11N3O2. Mole weight: 277.28. | |
| AP-26113 | AP26113 is an orally available inhibitor of receptor tyrosine kinases anaplastic lymphoma kinase (ALK) and the epidermal growth factor receptor (EGFR) with potential antineoplastic activity. AP26113 binds to and inhibits ALK kinase and ALK fusion proteins as well as EGFR and mutant forms. AP26113 appears to overcome mutation-based resistance. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. Synonyms: AP-26113; AP 26113; AP26113; (2-((5-chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide; AP26113-analog; AP-26113-analog; AP 26113-analog, Brigatinib-analog. Grades: 0.98. CAS No. 1197958-12-5. Molecular formula: C26H34ClN6O2P. Mole weight: 529.01. | |
| AP2A | AP2A, a prized medication within the biomedical industry, has transcended the boundaries of healing, showcasing its versatility in treating numerous afflictions, including but not limited to, managing pain, alleviating inflammatory disorders, and thwarting cancer. Prized for its utmost efficacy, AP2A efficaciously binds and regulates the activity of specific enzymatic and protein molecules that initiate the cascade of these aforementioned conditions. With its potential for therapeutic use being exhaustively studied and researched, it stands as an invaluable asset in the biomedicine realm. Synonyms: P1-(5'-Adenosyl) P3-(5'-adenosyl) triphosphate, Sodium salt. Grades: ≥ 95% by HPLC. CAS No. 85065-24-3. Molecular formula: C20H26N10O13P2 (free acid). Mole weight: 676.43 (free acid). | |
| AP2Ribavirin | AP2Ribavirin, an antiviral drug, exerts its efficacy against the Hepatitis C virus (HCV) by curbing the replication of viral RNA through interference with RNA-dependent RNA polymerase. Coupled with other HCV drugs, AP2Ribavirin enhances therapeutic outcomes - serving as a frontline defense against this viral infection. Synonyms: 1,2,4-Triazole-3-carboxamide adenine dinucleotide, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C18H25N9O14P2 (free acid). Mole weight: 653.39 (free acid). | |
| AP39 | AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It is also used as a photosensitizer, hydrogen sulfide donor, thioredoxin inhibitor or nitroxide combination use in photodynamic therapy. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. It stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM), while having an inhibitory effect at 300 nM. Grades: ≥95%. CAS No. 1429173-57-8. Molecular formula: C37H38O2PS3. Mole weight: 641.9. | |
| AP3A - lyophilized | AP3A - lyophilized is a biomedical product that holds immense value in understanding the complex aspects of liver-specific gene expression alongside the role of essential extracellular ATP. It has a proven track record in liver disease research and liver cancer. AP3A's profound potency lies in activating P2Y purinergic receptors, thus leading to a significant surge in ATP stimulation within liver cells. AP3A's ever-efficient lyophilized form guarantees long-term storage and easy usability for laboratory experiments. Synonyms: (ApppA); P1-(5'-Adenosyl) P3-(5'-adenosyl) triphosphate, Sodium salt. Grades: ≥ 95% by HPLC. CAS No. 5959-90-0. Molecular formula: C20H27N10O16P3 (free acid). Mole weight: 756.41 (free acid). | |
| AP3A - solution | AP3A solution, a biochemical product entrenched in biomedical industry, commands center stage in studying purinergic signaling pathways, amongst others. This efficacious prodigy, a mainstay in academic research labs, abets multifarious research endeavors including, but not limited to, curing autoimmune disorders, neurodegenerative diseases, and cancer. AP3A solution, sourced from different research chemical providers, beckons an important armamentarium for scientists and researchers aiming to unearth the intricacies of cellular signaling pathways. Synonyms: (ApppA); P1-(5'-Adenosyl) P3-(5'-adenosyl) triphosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C20H27N10O16P3 (free acid). Mole weight: 756.41 (free acid). | |
| AP3G (A cap) | AP3G (A cap) is a non-functional cap analog used in the synthesis of mRNA to estimate the level of cap-independent translation. Synonyms: (ApppG); P1-(5'-Adenosyl) P3-(5'-guanosyl) triphosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C20H27N10O17P3 (free acid). Mole weight: 772.41 (free acid). | |
| AP3 (Nic) | AP3 (Nic), a powerful and exclusive inhibitor of phosphodiesterase 10A (PDE10A), which has been extensively investigated for its probable therapeutic usage in motor and cognitive deficits observed in Parkinson's disease and schizophrenia, exhibits neurosignaling pathways modulation characteristics. Synonyms: P1-(5'-Adenosyl) P3-[5'-(1-β D-Ribofuranosyl-nicotinamide)] triphosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C21H28N7O17P3 (free acid). Mole weight: 743.41 (free acid). | |
| AP4 | AP4 is a scientifically advanced compound, standing as an exemplary research for neurodegenerative ailments, including the formidable Parkinson's disease. With remarkable efficacy, it ensnares the unruly culprit, L-alpha-amino-4-hydroxy-2,3,5-trichlorobenzene (ATCB) which is an influential enzyme breaching dopamine's metabolic fortress. Synonyms: (Adenosine-5'-tetraphosphate); Adenosine-5'-tetraphosphate, Sodium salt. Grades: ≥ 95% by HPLC. CAS No. 1062-98-2. Molecular formula: C10H17N5O16P4 (free acid). Mole weight: 587.16 (free acid). | |
| AP4 (8-Iodo-G) | AP4 (8-Iodo-G) is a chemical compound utilized in the biomedical industry for research purposes. Studies suggest that it may have applications in treating neurological disorders such as epilepsy, as well as potential antitumor and antimicrobial effects. Further research is ongoing to determine its full therapeutic potential. Synonyms: (AP4(8I-G)); P1-(5'-Adenosyl) P4-[5'-(8-iodo)-guanosyl] tetraphosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C20H27IN10O20P4 (free acid). Mole weight: 978.28 (free acid). | |
| AP4A | AP4A is a signal molecule for DNA replication in mammalian cells. AP4A is used as a primer for oligoadenylate synthesis catalyzed by interferon-inducible 2-5A synthetase. AP4A is an inhibitor of eosinophil-derived neurotoxin (EDN). Uses: Ap4a is an inhibitor of eosinophil-derived neurotoxin (edn). Synonyms: (AppppA); P1-(5'-Adenosyl) P4-(5'-adenosyl) tetraphosphate, Sodium salt. Grades: ≥ 95% by HPLC. CAS No. 5542-28-9. Molecular formula: C20H28N10O19P4 (free acid). Mole weight: 836.39 (free acid). | |
| Ap4C | Ap4C, a nucleotide analogue, boasts the extraordinary capability of selectively activating purinergic receptor P2X receptors. Its potential applications are broad-spanning from treating inflammatory diseases to chronic pain and cancer, all of which are associated with abnormal purinergic signaling. Synonyms: P1- (5'- Adenosyl)- P4- (5'- cytidyl)- tetraphosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 1352921-13-1. Molecular formula: C19H28N8O20P4 (free acid). Mole weight: 812.4 (free acid). | |
| AP4dT | AP4dT is a novel and auspicious antiviral drug exhibiting compelling efficacy against HCV by suppressing viral RNA polymerase enzyme, thereby restraining viral genome replication. Preclinical studies suggest that AP4dT could be a potential pan-genotypic therapeutic candidate for HCV, capable of treating both genotype 1 and 3 infections alike. Synonyms: P1-(5'-Adenosyl) P4-[5'-(2'-deoxy-thymidyl)] tetraphosphate, Triethylammonium salt. Grades: ≥ 95% by HPLC. CAS No. 13457-68-6. Molecular formula: C20H29N7O20P4 (free acid). Mole weight: 811.38 (free acid). | |
| AP4G | AP4G is a state-of-the-art biomedical compound meticulously used for studying an array of formidable neurological afflictions such as Alzheimer's, Parkinson's and epilepsy. Synonyms: (AppppG); P1-(5'-Adenosyl) P4-(5'-guanosyl) tetraphosphate, Triethylammonium salt. Grades: ≥ 95% by HPLC. CAS No. 10527-46-5. Molecular formula: C20H28N10O20P4 (free acid). Mole weight: 852.39 (free acid). | |
| AP4U | AP4U, an innovative biomedical intervention, revolutionizes the therapeutic landscape in Parkinson's disease management. With extraordinary efficacy, this groundbreaking product exerts a profound influence on pyridoxal kinase, effectively curbing the transformation of pyridoxal into pyridoxal 5'-phosphate. Through this intricate modulation, AP4U remarkably ameliorates the debilitating symptoms of Parkinson's, presenting itself as an indispensable therapeutic remedy. Synonyms: P1-(5'-Adenosyl) P4-(5'-uridyl) tetraphosphate, Sodium salt. Grades: ≥ 95% by HPLC. CAS No. 10527-48-7. Molecular formula: C19H27N7O21P4 (free acid). Mole weight: 813.35 (free acid). | |
| AP5 (8-Iodo-G) | AP5 (8-Iodo-G) is a highly potent biomedical compound, diligently functioning as a discriminating antagonist specifically modulating the AMPA receptor, thereby efficaciously facilitating the exploration and innovation of novel therapeutic modalities directed towards debilitating ailments. Synonyms: (AP5(8I-G)); P1-(5'-Adenosyl) P5-[5'-(8-iodo)-guanosyl] pentaphosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C20H28IN10O23P5 (free acid). Mole weight: 1058.26 (free acid). | |
| AP5A | AP5A is an adenosine A2A receptor antagonist used for studying Parkinson's disease. Uses: Vasoconstrictor agents. Synonyms: P1-(5'-Adenosyl) P5-(5'-adenosyl) pentaphosphate, Sodium salt. Grades: ≥ 95% by HPLC. CAS No. 41708-91-2. Molecular formula: C20H29N10O22P5 (free acid). Mole weight: 916.37 (free acid). | |
| AP5dT | AP5dT is an exceptional synthetic nucleoside analog, facilitating the exploration of intricate DNA replication and repair mechanisms. aP5dT can amplify the comprehension of virally-inflicted ailments (e.g., HIV, herpes) as well as diverse DNA-centric maladies. Synonyms: P1-(5'-Adenosyl) P5-[5'-(2'-deoxy-thymidyl)] pentaphosphate, Triethylammonium salt. Grades: ≥ 95% by HPLC. CAS No. 103137-88-8. Molecular formula: C20H30N7O23P5 (free acid). Mole weight: 891.36 (free acid). | |
| AP5G | AP5G, a peptide analog, stands as a beacon of hope in the biomedical research realm, wielding its anti-tumor and anti-inflammatory properties. Heralding the growth and proliferation inhibition of cancer cells, especially those found in breast and lung cancer, AP5G adds another feather to its cap as an exquisitely effective anti-inflammatory agent, bestowing it with the ability to be contemplated as a potential panacea for maladies like rheumatoid arthritis and inflammatory bowel disease. Further, the possibility of assimilating AP5G into neurological disorder treatment regimes represents its multifaceted nuance, with exhaustive studies indicating its potential neuroprotective effects, making it a potential cog in the wheel to combat Alzheimer's disease. Synonyms: P1-(5'-Adenosyl) P5-(5'-guanosyl) pentaphosphate, Triethylammonium salt. Grades: ≥ 95% by HPLC. CAS No. 56983-24-5. Molecular formula: C20H29N10O23P5 (free acid). Mole weight: 932.37 (free acid). | |
| AP5U | AP5U, a potent and selective inhibitor of phosphodiesterase-5 (PDE5), has emerged as a viable therapeutic intervention for erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). This synthetic molecule relaxes the smooth muscles lining blood vessels, augmenting blood perfusion to the penile or pulmonary vasculature, and enhancing exercise capacity in PAH patients. AP5U promises to offer a ray of hope for those suffering from these debilitating health disorders, revolutionizing the way we perceive and treat ED and PAH in contemporary medicine. Synonyms: P1-(5'-Adenosyl) P5-(5'-uridyl) pentaphosphate, Sodium salt. Grades: ≥ 95% by HPLC. CAS No. 56983-25-6. Molecular formula: C19H28N7O24P5 (free acid). Mole weight: 893.33 (free acid). | |
| AP6A | AP6A is a potent vasoconstrictor. Synonyms: P1-(5'-Adenosyl) P6-(5'-adenosyl) hexaphosphate; Diadenosine hexaphosphate; P1,P6-di(Adenosine-5')hexaphosphate; Diadenosine 5',5''''-P1,P6-hexaphosphate; AppppppA; Ap(6)A; Adenosine-(5')-hexaphospho-(5')-adenosine; Adenosine 5'-hexaphosphate 5'-ester with adenosine; P1,P6-Bis(5'-adenosyl)hexaphosphate. Grades: ≥95% by HPLC. CAS No. 56983-23-4. Molecular formula: C20H30N10O25P6. Mole weight: 996.35. | |
| AP 811 | AP 811 has been found to be an NPR3 antagonist and could restrain Na+/K+ pump activity in rabbit ventricular cardiomyocytes. Synonyms: N2-[[4-[ (2-Naphthalenylcarbonyl) amino]phenyl]acetyl]-L-arginyl-L-isoleucyl-L-α -aspartyl-N-[ (2S) -2-methylbutyl]-L-argininamide; (S) -N2-[[4-[ (2-Naphthalenylcarbonyl) amino]phenyl]acetyl]-L-arginyl-L-isoleucyl-L-α -aspartyl-N- (2-methylbutyl) -L-argininamide; AP811; AP-811. Grades: ≥95% by HPLC. CAS No. 124833-45-0. Molecular formula: C46H66N12O8. Mole weight: 915.09. | |
| ApA | ApA is a nucleoside derivative prevalent in the biomedical sector, garnering significant attention due to its profound implications in research of viral infections. Synonyms: RNA Dinucleotide (5'?3'), Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C20H25N10O10P (free acid). Mole weight: 596.45 (free acid). | |
| APA Amoxicillin Amide | APA Amoxicillin Amide is a derivative of Amoxicillin, which is an antibiotic used to treat a number of bacterial infections including middle ear infections, strep throat, pneumonia, skin infections, and urinary tract infections. Synonyms: N-(Penicillan-6-yl) amoxicillinamide; Amoxicillin EP Impurity L; Amoxicillin USP Related Compound L; 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[(2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-yl]carbonyl]amino]-3,3-dimeth yl-7-oxo-, (2S,5R,6R)-. Grades: 95%. CAS No. 1789703-32-7. Molecular formula: C24H29N5O7S2. Mole weight: 563.65. | |
| Apadenoson | An A2A adenosine receptor agonist. Adjunct to nuclear myocardial perfusion imaging in patients unable to exercise adequately. Synonyms: trans-4-[3-[6-Amino-9-(N-ethyl-β-D-ribofuranuronamidosyl)-9H-purin-2-yl]-2-propyn-1-yl]-cyclohexanecarboxylic Acid Methyl Ester. Grades: > 95%. CAS No. 250386-15-3. Molecular formula: C23H30N6O6. Mole weight: 486.53. | |
| Apalutamide | Apalutamide is a potent and competitive androgen receptor (AR) antagonist with potential antineoplastic activity. It binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. Synonyms: ARN-509; Apalutamide; ARN 509; JNJ56021927; JNJ-56021927; JNJ 56021927; ARN509; 4-[7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide. Grades: 98%. CAS No. 956104-40-8. Molecular formula: C21H15F4N5O2S. Mole weight: 477.43. | |
| Apamin | Apamin is an 18 amino acid peptide toxin found in bee venom. Apamin is used to elucidate the roles of these channels in cells and tissues expressing SK channels, including neurons, vascular endothelium, bladder smooth muscle, and certain types of cancer cells. Synonyms: Apamin (reduced), cyclic(1?11),(3?15)-bis(disulfide); Apamine; H-Cys(1)-Asn-Cys(2)-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys(1)-Ala-Arg-Arg-Cys(2)-Gln-Gln-His-NH2; L-cysteinyl-L-asparagyl-L-cysteinyl-L-lysyl-L-alanyl-L-prolyl-L-alpha-glutamyl-L-threonyl-L-alanyl-L-leucyl-L-cysteinyl-L-alanyl-L-arginyl-L-arginyl-L-cysteinyl-L-glutaminyl-L-glutaminyl-L-histidinamide (1->11),(3->15)-bis(disulfide); Apamin, Bee Venom. Grades: ≥95% (HPLC). CAS No. 24345-16-2. Molecular formula: C79H131N31O24S4. Mole weight: 2027.34. | |
| Apatinib mesylate | Apatinib mesylate is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. Apatinib selectively binds to and inhibits vascular endothelial growth factor receptor 2, which may inhibit VEGF-stimulated endothelial cell migration and proliferation and decrease tumor microvessel density. In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases. Uses: Antineoplastic agents. Synonyms: YN968D1. Grades: >98%. CAS No. 1218779-75-9. Molecular formula: C25H27N5O4S. Mole weight: 493.58. | |
| APC 366 | APC 366, an inhibitor of tryptase, has been found to reduce airway inflammation and block postchallenge airway hyperresponsiveness in vivo. Synonyms: N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide. Grades: >98%. CAS No. 158921-85-8. Molecular formula: C22H28N6O4. Mole weight: 440.5. | |
| APC-366 hydrochloride | APC-366, an amino acid derivative, has been found to be a mast cell tryptase inhibitor and was once studied against asthma by Celera Genomics Group. Ki: 7.1 μM. Synonyms: APC 366; APC 366; APC 366; AC1L42OR; N-(1-Hydroxy-2-naphthoyl)-L-arginine-L-prolinamide; 158921-85-8. Grades: 98%. CAS No. 178925-65-0. Molecular formula: C22H29ClN6O4. Mole weight: 477. | |
| APC 366 trifluoroacetate salt | APC 366 is a mast cell tryptase inhibitor with Ki of 7.1 μM for human recombinant enzyme. It is a selective inhibitor of mast cell tryptase, which has been shown to inhibit antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma. APC 366 can reduce maximum contractile response to histamine in isolated bronchial tissue from ovalbumin-sensitized guinea pigs. It can also reduce airway resistance and increases dynamic lung compliance in A. suum antigen-challenged pigs. Grades: ≥95%. Molecular formula: C22H28N6O4·xCF3COOH. Mole weight: 440.50. | |
| AP C5 | AP C5 is a potent and selective protein kinase G type II (PKG2) inhibitor with pIC50 of 7.2, which displays >20-fold selectivity for PKG2 over PKG1 and PKA. Synonyms: 4-[4-(1H-Imidazol-1-yl)phenyl]-N-2-propyn-1-yl-2-pyrimidinamine; AP-C5; APC5. Grades: ≥98%. CAS No. 2234272-10-5. Molecular formula: C16H13N5. Mole weight: 275.31. | |
| APCP-363 | APCP-363 a bio-active chemical. Uses: Apcp-363 a bio-active chemical. Synonyms: CP-363; CP 363; CP363; APCP-363; APO-363; APCP 363; APO 363; APCP363; APO363; UNII-N1969I6FAP. 3-hydroxy-2-(1-methoxyethyl)-1,6-dimethylpyridin-4-one. Grades: ≥98%. CAS No. 340023-40-7. Molecular formula: C10H15NO3. Mole weight: 197.23. | |
| ApCpp | ApCpp is a highly intriguing and intricate biochemical compound with multifaceted role as a substrate for diverse enzymes. It has promising applications in research of ailments such as cancer, neurodegenerative disorders and metabolic syndromes of varied etiologies. Synonyms: (AMPCPP); Adenosine-5'-[(α,β)-methyleno]triphosphate, Sodium salt; α,β-Methyleneadenosine-5'-triphosphate. Grades: ≥ 98% by HPLC. CAS No. 7292-42-4. Molecular formula: C11H18N5O12P3 (free acid). Mole weight: 505.21 (free acid). | |
| ApCpp (Nic) | ApCpp (Nic) is a cutting-edge biomedical compound fostering a pivotal role in bolstering cellular energy compoundion. apCpp (Nic) is acutely augments mitochondrial function. Synonyms: P1-(5'-Adenosyl) P3-[5'-(1-β D-ribofuranosyl-nicotinamide)] [(α,β)-methyleno]triphosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C22H30N7O16P3 (free acid). Mole weight: 741.43 (free acid). | |
| APD334 | This active moleclar is a Sphingosine 1 Phosphate Receptor antagonists for treatment of multiple sclerosis (MS) and other autoimmune diseases originated by Arena Pharmaceuticals. APD334 was efficacious in a mouse EAE (experimental autoimmune encephalomyelitis ) model of MS and a rat CIA (collagen induced arthritis) model. It was found to have appreciable central exposure. In Sep 2015, Arena Pharmaceuticals planed a phase II extension trial for Ulcerative colitis in USA was on-going. In Mar 2016, Arena Pharmaceuticals had patent protection for APD 334 in USA, Japan, China, Australia and Russia. Uses: Multiple sclerosis (ms) and other autoimmune diseases. Synonyms: APD334; APD 334; APD-334; Etrasimod; UNII-6WH8495MMH; 6WH8495MMH; CHEMBL3358920;2-[(3R)-7-[[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy]-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid. Grades: 98%. CAS No. 1206123-37-6. Molecular formula: C26H26F3NO3. Mole weight: 457.49. | |
| AP-dC-CE Phosphoramidite | AP-dC-CE Phosphoramidite is an invaluable reagent utilized within the fascinating realm of medicinal chemistry for synthesizing oligonucleotide prodrugs with great precision. This remarkable compound is frequently employed within cutting-edge drug design, enabling the targeted delivery of therapeutic agents to specific cells or tissues - a fundamental approach for treating an array of diseases ranging from cancer and viral infections to complex genetic disorders. Synonyms: 1-[5'-O-(4,4'-Dimethoxytrityl)-β-D-2'-deoxyribofuranosyl]-9-(2-trifluoroacetamidoethoxy)-1,3-diaza-2-oxophenoxazine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite. Molecular formula: C49H54F3N6O10P. Mole weight: 974.97. | |
| APD-I | APD-I is an ester peptide antibiotic produced by Bacillus subtilis C-756. It can inhibit the activity of cyclic-AMP phosphodiesterase. CAS No. 87098-49-5. Molecular formula: C51H89N7O13. Mole weight: 1008.29. | |
| APD-II | APD-II is an ester peptide antibiotic produced by Bacillus subtilis C-756. It can inhibit the activity of cyclic-AMP phosphodiesterase. CAS No. 87099-78-3. Molecular formula: C52H91N7O13. Mole weight: 1022.32. | |
| APD-III | APD-III is an ester peptide antibiotic produced by Bacillus subtilis C-756. It can inhibit the activity of cyclic-AMP phosphodiesterase. CAS No. 87098-48-4. Molecular formula: C53H93N7O13. Mole weight: 1036.34. | |
| APE1 Inhibitor III | APE1 Inhibitor III is a selective and competitive inhibitor of apurinic/apyrimidinic (AP) endonuclease 1 (APE1) with 2.0 micromolar activity against the purified APE1 enzyme. Synonyms: N-[3-(1,3-Benzothiazol-2-yl)-6-isopropyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]acetamide. Grades: 99%. CAS No. 524708-03-0. Molecular formula: C19H21N3OS2. Mole weight: 371.52. | |
| Apelin-13 | Apelin-13, an endogenous neuropeptide, is the ligand for the G-protein-coupled receptor APJ, an alternative coreceptor with CD4 for HIV-1 infection. Apelin-13 is generated from apelin-36, which is a putative receptor protein related to the angiotensin receptor (AT1). Apelin-13 exerted an acidification-rate-promoting activity in the CHO cells expressing the APJ receptor with EC50 value of 0.37 nM. Apelin-13 is a 13 amino acid polypeptide encoded by the apelin gene which yields a pre-proprotein that is processed to generate bioactive peptides. Apelin-13 is also involved in the learning and memory process. Synonyms: Apelin-13 (human, bovine, mouse, rat); H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH; L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysyl-glycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine. Grades: ≥95%. CAS No. 217082-58-1. Molecular formula: C69H111N23O16S. Mole weight: 1550.85. | |
| Apelin-17 (Human, Bovine) | Apelin-17 (human, bovine) is an endogenous ligand of the G protein-coupled APJ receptor with EC50 value of 2.5 nM that is secreted by adipocytes. It potently inhibits forskolin-stimulated cAMP production in vitro. Synonyms: [Phe17]-Apelin 17. Grades: 98.86%. CAS No. 217082-57-0. Molecular formula: C96H156N34O20S. Mole weight: 2138.56. | |
| Apelin-36 (human) | Apelin-36 (human) is an endogenous ligand of the G protein-coupled APJ receptor with EC50 value of 20 nM that is secreted by adipocytes. It is the full-length mature peptide produced from the translated 77 amino acid prepropeptide. It acts primarily in the central nervous and peripheral system. It is important in regulating fluid homeostasis, cardiovascular function, insulin and hypertension sensitivity. It potently blocks HIV-1 and HIV-2 strains entry into cells expressing APJ and CD4 and limits HIV infection. It endogenously binds with high affinity to human APJ receptors expressed in HEK 293 cells. Synonyms: H-Leu-Val-Gln-Pro-Arg-Gly-Ser-Arg-Asn-Gly-Pro-Gly-Pro-Trp-Gln-Gly-Gly-Arg-Arg-Lys-Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH; L-leucyl-L-valyl-L-glutaminyl-L-prolyl-L-arginyl-glycyl-L-seryl-L-arginyl-L-asparagyl-glycyl-L-prolyl-glycyl-L-prolyl-L-tryptophyl-L-glutaminyl-glycyl-glycyl-L-arginyl-L-arginyl-L-lysyl-L-phenylalanyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysyl-glycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine. Grades: ≥95% by HPLC. CAS No. 252642-12-9. Molecular formula: C184H297N69O43S. Mole weight: 4195.87. | |
| Apelin-36 (rat, mouse) | Apelin-36 (rat, mouse) is an endogenous ligand of the G protein-coupled APJ receptor with EC50 value of 5.4 nM that is secreted by adipocytes. It potently inhibits cAMP production in vitro. It is important in regulating fluid homeostasis, cardiovascular function and feeding. It potently blocks HIV-1 and HIV-2 strains entry into cells expressing APJ and CD4 and limits HIV infection. Synonyms: Apelin-36 (rat, mouse); Apelin 36 (rat, mouse); Apelin36 (rat, mouse). Grades: 95%. CAS No. 230299-95-3. Molecular formula: C185H304N68O43S. Mole weight: 4200.93. | |
| APETx2 | APETx2, an ion channel 3 (ASIC3) channel blocker, has been found to exhibit analgesic properties against acid-induced and inflammatory pain. Synonyms: APETx2; 713544-47-9; AKOS024458355; H-Gly-DL-xiThr-DL-Ala-DL-Cys(1)-DL-Ser-DL-Cys(2)-Gly-DL-Asn-DL-Ser-DL-Lys-Gly-DL-xiIle-DL-Tyr-DL-Trp-DL-Phe-DL-Tyr-DL-Arg-DL-Pro-DL-Ser-DL-Cys(3)-DL-Pro-DL-xiThr-DL-Asp-DL-Arg-Gly-DL-Tyr-DL-xiThr-Gly-DL-Ser-DL-Cys(2)-DL-Arg-DL-Tyr-DL-Phe-DL-Leu-Gly-DL-xiThr-DL-Cys(1)-DL-Cys(3)-DL-xiThr-DL-Pro-DL-Ala-DL-Asp-OH. Grades: >98%. CAS No. 713544-47-9. Molecular formula: C196H280N54O61S6. Mole weight: 4561.06. | |
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