BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| A2G1 Glycan, 2-AA labelled | A2G1 Glycan, 2-AA labelled is a crucial component in the biomedicine industry used to study glycosylation patterns, which plays a critical role in numerous diseases, including cancer, diabetes, and inflammation. As a fluorescently labelled glycan, it enables researchers to investigate the glycosylation process related to protein-protein and protein-ligand interactions, leading to better understanding and potential therapeutic interventions for these diseases. |  |
| A2G1 Glycan, 2-AB labelled | | |
| A2G1 N-Glycan | A2G1 N-Glycan is a vital component used for studying glycosylation and its impact on diseases such as cancer is autoimmune disorders and neurodegenerative diseases. This glycan plays a crucial role in understanding cellular processes, protein interactions and targeted compound delivery. It aids in the characterization and analysis of glycoproteins. Synonyms: Asialo-, bi-antennary N-linked glycan. Mole weight: 1625. | |
| A2 Glycan, 2-AA labelled | A2 Glycan, 2-AA labelled is a vital tool in biomedicine used for studying glycan structures and their involvement in various diseases. It is utilized to analyze glycan compositions and monitor alterations in glycosylation patterns. | |
| A2 Glycan, 2-AB labelled | | |
| A2-MHC | A peptide used in the research on the treatment of melanoma. | |
| A2 N-Glycan | A2 N-Glycan is an indispensable biocompatible and bioactive glycobiology compound, aiding in the meticulous analysand comprehensive characterization of glycoproteins. Synonyms: Disialo (2,6), biantennary (A2); A2 glycan; A2G2S2 N-glycan; Di-sialylated, galactosylated, bi-antennary N-linked glycan Mannotriose-di-(N-acetyl-D-glucosamine), bis([N-acetyl-D-neuraminyl]-galactosyl-[N-acetyl-D-glucosaminyl]). Grades: 95%. CAS No. 71496-55-4. Molecular formula: C84H138N6O62. Mole weight: 2224.00. | |
| A 32390A | A 32390A is an antibiotic produced by Pyrenochaeta sp. (NRRL-5786). It has anti-gram-positive bacteria and fungi activity. It also inhibits the activity of dopamine tetra-hydroxylase, can reduce the level of norepinephrine in the heart and adrenal glands, and has a hypotensive effect on hypertensive rats. Synonyms: 1,6-Di-O-2-isocyano-3-methylcrotonyl-D-mannitol; Antibiotic A 32390A; A32390A. Grades: >98%. CAS No. 61241-59-6. Molecular formula: C18H24N2O8. Mole weight: 396.39. | |
| A-32724 A | A-32724 A is an antibiotic produced by Chaetomella raphigera A-32724. It has anti-Gram-positive bacteria, negative bacteria and fungi activity, and has the effect of lowering blood pressure and inhibiting Glucosyl tranferaese (Glucosyl tranferaese). CAS No. 85528-23-0. Molecular formula: C33H56Na2O11S2. Mole weight: 738.90. | |
| A-32724 B | A-32724 B is an antibiotic produced by Chaetomella raphigera A-32724. It has anti-Gram-positive bacteria, negative bacteria and fungi activity, and has the effect of lowering blood pressure and inhibiting Glucosyl tranferaese (Glucosyl tranferaese). CAS No. 85537-32-2. Molecular formula: C33H56Na2O11S2. Mole weight: 738.90. | |
| A 33 | A 33 is a potent and selective PDE4B inhibitor (IC50 = 15 nM) that exhibits >100-fold selectivity for PDE4B over 4D. Synonyms: 2-[4-[[2-(5-Chloro-2-thienyl)-5-ethyl-6-methyl-pyrimidin-4-yl]amino]phenyl]acetic acid. Grades: ≥98%. CAS No. 915082-52-9. Molecular formula: C19H18ClN3O2S. Mole weight: 387.88. | |
| A-33853 | A-33853 is an antibiotic produced by Streptomyces sp. (NRRL 12068). It has anti-gram-positive bacteria, viruses, poultry coccidioides, trichomonas and mosquito larvae. Synonyms: Antibiotic A 33853; 4-Benzoxazolecarboxylic acid, 2-(3-hydroxy-2-(((3-hydroxy-2-pyridinyl)carbonyl)amino)phenyl)-. Grades: >98%. CAS No. 80148-45-4. Molecular formula: C20H13N3O6. Mole weight: 391.33. | |
| A 350619 hydrochloride | A 350619 hydrochloride is an activator of soluble guanylyl cyclase (sGC) that stimulates basal sGC and synergistically activates sGC in the presence of NO. It is effective for the use of ED treatment. Uses: The treatment of ed. Synonyms: A-350619 hydrochloride; A350619 hydrochloride; A 350619 hydrochloride; 3-[2-[(4-Chlorophenyl)thiophenyl]-N-[4-(dimethylamino)butyl]-2-propenamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 1217201-17-6. Molecular formula: C21H25ClN2OS.HCl. Mole weight: 425.41. | |
| A 357300 hydrochloride | A 357300 hydrochloride is a potent and reversible inhibitor of methionine aminopeptidase-2 (MetAP-2). In murine models, it significantly inhibits CHP-134-derived neuroblastoma s.c. xenograft growth rate with a treatment-to-control (T/C) ratio at day 24 of 0.19 (P < 0.001) without toxicity. Uses: Novel treatment of neuroblastoma. Synonyms: A-357300; A 357300; A357300; N'-(3-amino-2-hydroxy-5-(isopropylthio)pentanoyl)-3-chlorobenzohydrazide hydrochloride. Grades: 99%. CAS No. 369358-07-6. Molecular formula: C15H22ClN3O3S.HCl. Mole weight: 396.33. | |
| A-366 | A-366 is a peptide-competitive inhibitor of the G9a/GLP histone lysine methyltransferase (IC50 = 3.3 nM) and is approximately 1000-fold selective over other methyltransferases. Synonyms: A 366; A366. CAS No. 1527503-11-2. Molecular formula: C19H27N3O2. Mole weight: 329.44. | |
| A 39183A | It is an anthraquinone antibiotic produced by the strain of streptomyces sp. It has broad spectrum antimicrobial activity against both sensitive and resistant strains, including many anaerobic bacteria. It also has the activity against gram-positive and gram-negative bacteria. Synonyms: Antibiotic A 39183A; (1S,1'S,2S,2'S)-1,1'-Diacetyl-2,2',5,5',10,10'-hexahydroxy-2,2'-dimethyl-2,2',3,3'-tetrahydro-9,9'-bianthracene-4,4'(1H,1'H)-dione. Grades: >95% by HPLC. CAS No. 79426-51-0. Molecular formula: C34H30O10. Mole weight: 598.60. | |
| A3-APO | A3-APO is an antimicrobial peptide produced by Synthetic construct. It has antibacterial activity. Synonyms: (H-Chex-Arg-Pro-Asp-Lys-Pro-Arg-Pro-Tyr-Leu-Pro-Arg-Pro-Arg-Pro-Pro-Arg-Pro-Val-Arg)2-Dab-NH2 (where Chex is 1-amino-cyclohexane carboxylic acid and Dab is 2,4-diamino-butyric acid). Grades: 97%. | |
| A3 Glycan, 2-AA labelled | A3 Glycan, 2-AA labelled, a critical and indispensable instrument in the biomedical sector, is utilized for exploring glycan expression in diverse illnesses, notably cancer and autoimmune disorders. It acts as the ideal substance for glycan analysis and characterization by advanced technologies like mass spectrometry and chromatography. Furthermore, A3 Glycan, 2-AA labelled is crucial for triggering glycomics-related biomarker discovery scientific investigations ensuing precision medication breakthroughs. | |
| A3 Glycan, 2-AB labelled | | |
| A3 N-Glycan | A3 N-Glycan is a vital biomolecule commonly found on the surface of many cells. It plays a crucial role in various biological processes, such as cell signaling, immune response, and disease progression. This particular N-glycan is extensively studied in the biomedical industry due to its involvement in numerous diseases, including cancer, autoimmune disorders, and infectious diseases. Synonyms: Trisialylated, galactosylated, triantennary (A3); A3 glycan; A3G3S3 Glycan; (NeuNAc-Gal-GlcNAc)3Man3(GlcNAc)2; Tri-sialylated, galactosylated, tri-antennary N-linked glycan; Mannotriose-di-(N-acetyl-D-glucosamine), tris(sialyl-galactosyl-N-acetyl-D-glucosaminyl. Grades: ≥85%. CAS No. 145164-24-5. Molecular formula: C109H178N8O80. Mole weight: 2880.59. | |
| A40926 | A40926 is an antibiotic against Gram positive bacteria particularly for Neisseria gonorrhoeae. It acts by inhibiting the synthesis of bacterial cell wall. It is also the precursor to dalbavanain. Synonyms: Dalbavancin Impurity. Grades: 75%. CAS No. 102961-72-8. Molecular formula: C88H101Cl3N10O28. Mole weight: 1853.15. | |
| A40926-B2 | A40926-B2 is an impurity of A40926, an antibiotic against Gram positive bacteria particularly for Neisseria gonorrhoeae. A40926 acts by inhibiting the synthesis of bacterial cell wall. Synonyms: Antibiotic A-40926 B2. CAS No. 871088-55-0. Molecular formula: C84H90Cl2N8O29. Mole weight: 1746.5. | |
| A40926-ISO B0 | A40926-ISO B0 is an impurity of A40926, an antibiotic against Gram positive bacteria particularly for Neisseria gonorrhoeae. A40926 acts by inhibiting the synthesis of bacterial cell wall. | |
| A40926-MAG | A40926-MAG is an impurity of A40926, an antibiotic against Gram positive bacteria particularly for Neisseria gonorrhoeae. A40926 acts by inhibiting the synthesis of bacterial cell wall. | |
| A 410099.1 | A 410099.1 is a high affinity XIAP antagonist (Kd = 16 nM for the BIR3 domain of XIAP). Exhibits cytotoxicity in a wide range of cancer cell lines in vitro (EC50 = 13 nM in MDA-MB-231 cells). Also displays antitumor activity in a mouse breast cancer xenograft model. Enhances TRAIL-induced apoptosis in chronic lymphocytic leukemia (CLL) cells. Synonyms: N-Methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-L-prolinamide hydrochloride. Grades: ≥98%. CAS No. 762274-58-8. Molecular formula: C27H40N4O3·HCl. Mole weight: 505.09. | |
| A41030A | A41030A is a glycopeptide antibiotic produced by Streptomyces virginiae A41030. Activity against gram-positive bacteria. Synonyms: Desulfo-A47394. CAS No. 89139-41-3. Molecular formula: C58H44Cl3N7O18. Mole weight: 1233.36. | |
| A41030B | A41030B is a glycopeptide antibiotic produced by Streptomyces virginiae A41030. Activity against gram-positive bacteria. Synonyms: Antibiotic L 17392; Teicoplanin aglycone; Antibiotic A 41030B. CAS No. 89139-42-4. Molecular formula: C58H45Cl2N7O18. Mole weight: 1198.92. | |
| A41030C | A41030C is a glycopeptide antibiotic produced by Streptomyces virginiae A41030. Activity against gram-positive bacteria. Synonyms: Antibiotic A 41030C; 7-Demethyl-64-O-demethyl-19-deoxy-11-O-galactosyl-22,31,35-trichlororistomycin A aglycone; Ristomycin A aglycone, 7-demethyl-64-O-demethyl-19-deoxy-11-O-galactosyl-22,31,35-trichloro-. CAS No. 89140-21-6. Molecular formula: C64H54Cl3N7O23. Mole weight: 1395.50. | |
| A41030E | A41030E is a glycopeptide antibiotic produced by Streptomyces virginiae A41030. Activity against gram-positive bacteria. Synonyms: Antibiotic A 41030 E. CAS No. 89139-43-5. Molecular formula: C58H46ClN7O18. Mole weight: 1164.47. | |
| A41030F | A41030F is a glycopeptide antibiotic produced by Streptomyces virginiae A41030. Activity against gram-positive bacteria. Synonyms: Antibiotic A 41030 F. CAS No. 89140-20-5. Molecular formula: C70H64Cl3N7O28. Mole weight: 1557.64. | |
| A-42867 | A-42867 is a glycopeptide antibiotic produced by Nocardia sp. It has activity against Gram-positive bacteria, mycobacteria, Enterococcus faecalis and Clostridium difficile. Synonyms: Antibiotic 42867; 22-O-(3-Amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-44-O-de(2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyl)-44-O-(O-(6-deoxy-alpha-D-mannopyranosyl)-D-glucosyl)vancomycin. CAS No. 122753-17-7. Molecular formula: C72H86ClN9O28. Mole weight: 1560.95. | |
| A 438079 hydrochloride | A 438079 hydrochloride is a competitive P2X7 receptor antagonist with pIC50 value of 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line. It protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, but not by inflammasome activation. It partially but significantly prevented the 6-OHDA-induced depletion of striatal DA stores. Synonyms: 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine hydrochloride;A-438079 HCl;A-438079 hydrochloride; A438079 hydrochloride; A 438079 hydrochloride. Grades: >98 %. CAS No. 899507-36-9. Molecular formula: C13H10Cl3N5. Mole weight: 342.61. | |
| A-443654 | A-443654 is a potent small-molecule inhibitor of all three Akt serine/threonine kinases, induces Akt Ser-473 phosphorylation in all human cancer cell lines tested, including PTEN- and TSC2-deficient lines. It inhibits Akt-dependent signal transduction in cells and in vivo in a dose-responsive manner. Synonyms: A443564; A-443564; A 443564. Grades: >98%. CAS No. 552325-16-3. Molecular formula: C24H23N5O. Mole weight: 397.47. | |
| A47934 | A47934 is a glycopeptide antibiotic produced by Streptomyces toyocaensis NRRL15009. Activity against gram-positive bacteria. Synonyms: A-47934 Antibiotic; Antibiotic A 47934. CAS No. 90039-80-8. Molecular formula: C58H44Cl3N7O21S. Mole weight: 1313.43. | |
| A 484954 | A 484954 is a eukaryotic elongation factor-2 (eEF-2) kinase inhibitor (IC50 = 0.28 μM in enzymatic assay). A 484954 reduces eEF-2 phosphorylation with little effect on cancer cell growth. Synonyms: A-484954; A 484954; A484954; 7-Amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyrimidine-6-carboxamide. Grades: ≥98% by HPLC. CAS No. 142557-61-7. Molecular formula: C13H15N5O3. Mole weight: 289.29. | |
| A-500359A | A-500359A is a bacterial translocase-1 (Translocase I, EC 2.7. 8.13) inhibitor produced by Streptomyces griseus SANK 60196. It has the activity of inhibiting translocase-1, IC50 is 0.017 μmol/L, and the IC50 of inhibiting peptidoglycan biosynthesis is 0.68 μmol/L. It also has activity against Mycobacterium smegmatis, Streptococcus pneumoniae and Streptococcus pyogenes, with an MIC of 6.25-12.5 μg/mL. CAS No. 254449-20-2. Molecular formula: C24H33N5O12. Mole weight: 583.54. | |
| A-500359C | A-500359C is a bacterial translocase-1 (Translocase I, EC 2.7. 8.13) inhibitor produced by Streptomyces griseus SANK 60196. It has activity against Mycobacterium smegmatis, Streptococcus pneumoniae and Streptococcus pyogenes, with an MIC of 6.25-12.5 μg/mL. CAS No. 254449-21-3. Molecular formula: C23H31N5O12. Mole weight: 569.52. | |
| A-500359D | A-500359D is a bacterial translocase-1 (Translocase I, EC 2.7. 8.13) inhibitor produced by Streptomyces griseus SANK 60196. It has activity against Mycobacterium smegmatis, Streptococcus pneumoniae and Streptococcus pyogenes, with an MIC of 6.25-12.5 μg/mL. CAS No. 254449-22-4. Molecular formula: C24H33N5O11. Mole weight: 567.54. | |
| A-500359E | A-500359E is a bacterial translocase-1 (Translocase I, EC 2.7. 8.13) inhibitor produced by Streptomyces griseus SANK 60196. It has activity against Mycobacterium smegmatis, Streptococcus pneumoniae and Streptococcus pyogenes, with an MIC of 6.25-12.5 μg/mL. Synonyms: A-500359 E. Molecular formula: C18H23N3O12. Mole weight: 473.39. | |
| A-500359F | A-500359F is a bacterial translocase-1 (Translocase I, EC 2.7. 8.13) inhibitor produced by Streptomyces griseus SANK 60196. It has activity against Mycobacterium smegmatis, Streptococcus pneumoniae and Streptococcus pyogenes, with an MIC of 6.25-12.5 μg/mL. Molecular formula: C17H21N3O12. Mole weight: 459.36. | |
| A-500359G | A-500359G is a bacterial translocase-1 (Translocase I, EC 2.7. 8.13) inhibitor produced by Streptomyces griseus SANK 60196. It has activity against Mycobacterium smegmatis, Streptococcus pneumoniae and Streptococcus pyogenes, with an MIC of 6.25-12.5 μg/mL. Molecular formula: C22H29N5O12. Mole weight: 555.49. | |
| A-500359H | A-500359H is a bacterial translocase-1 (Translocase I, EC 2.7. 8.13) inhibitor produced by Streptomyces griseus SANK 60196. It has activity against Mycobacterium smegmatis, Streptococcus pneumoniae and Streptococcus pyogenes, with an MIC of 6.25-12.5 μg/mL. Molecular formula: C16H19N3O12. Mole weight: 445.33. | |
| A-500359 M-1 | A-500359 M-1 is a bacterial translocase-1 (Translocase I, EC 2.7. 8.13) inhibitor produced by Streptomyces griseus SANK 60196. It has activity against Mycobacterium smegmatis, Streptococcus pneumoniae and Streptococcus pyogenes, with an MIC of 6.25-12.5 μg/mL. Synonyms: N-[2- ({2-[ (6-{[ (2S, 3S, 4R, 5R) -5- (2, 4-Dioxo (1, 3-dihydropyrimidinyl) ) -4-hydroxy-3-methoxyoxolan-2-yl]carbamoylmethoxy} (4S, 5S, 6S) -4, 5-dihydroxy-4H-5, 6-dihydropyran-2-yl) carbonylamino]ethyl}disulfanyl) ethyl]acetamide. Molecular formula: C23H33N5O12S2. Mole weight: 635.66. | |
| A-500359 M-2 | A-500359 M-2 is a bacterial translocase-1 (Translocase I, EC 2.7. 8.13) inhibitor produced by Streptomyces griseus SANK 60196. It has activity against Mycobacterium smegmatis, Streptococcus pneumoniae and Streptococcus pyogenes, with an MIC of 6.25-12.5 μg/mL. Synonyms: N-((3R,6R)-3-Methyl-5-oxo(1,4-thiazaperhydroepin-6-yl))(6-{[(2S,3S,4R,5R)-5-(2,4-dioxo(1,3-dihydropyrimidinyl))-4-hydroxy-3-methoxyoxolan-2-yl]carbamoylmethoxy}(4S,5S,6S)-4,5-dihydroxy(4H-5,6-dihydropyran-2-yl))carboxamide. Molecular formula: C23H31N5O12S. Mole weight: 601.58. | |
| A-51493A | A-51493A is an anthraquinone antibiotic produced by Streptomyces humifer. Activity against gram-positive bacteria. Synonyms: 121245-06-5; A51493A; AC1L52A8; A51493A; A-51493A; PL024209. Grades: >98%. CAS No. 121245-06-5. Molecular formula: C30H31NO10. Mole weight: 565.57. | |
| A-53930 A | A-53930 A is a Ca2+ channel blocker produced by Streptomyces vinaceusdrappus SANK 62394. It selectively blocks the activity of N-type Ca2+ channels, but does not inhibit L-type Ca2+ channels. It has weak activity against Gram-negative bacteria. Synonyms: 4H-Imidazo(4,5-c)pyridin-4-one, 1,3a,5,6,7,7a-hexahydro-2-((2-((3-amino-6-(((3S)-3-amino-6-(((3S)-3-amino-6-(((3S)-3,6-diamino-1-oxohexyl)amino)-1-oxohexyl)amino)-1-oxohexyl)amino)-1-oxohexyl)amino)-6-O-(aminocarbonyl)-2-deoxy-beta-D-gulopyranosyl)amino)-7-hydroxy-, (3aS,7R,7aS)-. CAS No. 182410-79-3. Molecular formula: C37H70N14O11. Mole weight: 887.04. | |
| A-53930 B | A-53930 B is a Ca2+ channel blocker produced by Streptomyces vinaceusdrappus SANK 62394. It selectively blocks the activity of N-type Ca2+ channels, but does not inhibit L-type Ca2+ channels. It has weak activity against Gram-negative bacteria. Synonyms: 4H-Imidazo(4,5-c)pyridin-4-one, 1,3a,5,6,7,7a-hexahydro-2-((6-O-(aminocarbonyl)-2-deoxy-2-(((3S,10S,17S,24S,31S)-3,10,17,24,31,34-hexamino-1,8,15,22,29-pentaoxo-7,14,21,28-tetraazatetratriacont-1-yl)amino)-beta-D-gulopyranosyl)amino)-7-hydroxy-, (3aS,7R,7aS)-. CAS No. 182697-76-3. Molecular formula: C43H82N16O12. Mole weight: 1015.21. | |
| A-54145A | A metabolite of Argatroban, a medication for the prevention and treatment of thrombosis. Synonyms: Antibiotic A 54145A; A-54145 A. Grades: > 95%. CAS No. 153886-68-1. Molecular formula: C10H13NO3S. Mole weight: 227.28. | |
| A-54145A1 | A-54145A1 is an ester peptide antibiotic produced by Streptomyces fradiae. It has anti-Gram-positive bacteria activity with an MIC of 0.25-32 μg/mL. Synonyms: Antibiotic A 54145A1; A-54145 A1. CAS No. 129804-73-5. Molecular formula: C72H109N17O27. Mole weight: 1644.73. | |
| A-54145B | A-54145B is an ester peptide antibiotic produced by Streptomyces fradiae. It has anti-Gram-positive bacteria activity with an MIC of 0.25-32 μg/mL. Synonyms: A-54145 B. CAS No. 129804-74-6. Molecular formula: C73H111N17O27. Mole weight: 1658.76. | |
| A-54145B1 | A-54145B1 is an ester peptide antibiotic produced by Streptomyces fradiae. It has anti-Gram-positive bacteria activity with an MIC of 0.25-32 μg/mL. Synonyms: A-54145 B1. CAS No. 129804-75-7. Molecular formula: C73H111N17O27. Mole weight: 1658.76. | |
| A-54145C | A-54145C is an ester peptide antibiotic produced by Streptomyces fradiae. It has anti-Gram-positive bacteria activity with an MIC of 0.25-32 μg/mL. Synonyms: A-54145 C. CAS No. 129804-76-8. Molecular formula: C73H111N17O27. Mole weight: 1658.76. | |
| A-54145D | A-54145D is an ester peptide antibiotic produced by Streptomyces fradiae. It has anti-Gram-positive bacteria activity with an MIC of 0.25-32 μg/mL. Synonyms: A-54145 D. CAS No. 129804-77-9. Molecular formula: C73H111N17O27. Mole weight: 1658.76. | |
| A-54145E | A-54145E is an ester peptide antibiotic produced by Streptomyces fradiae. It has anti-Gram-positive bacteria activity with an MIC of 0.25-32 μg/mL. Synonyms: A-54145 E. CAS No. 129804-78-0. Molecular formula: C74H113N17O27. Mole weight: 1672.78. | |
| A-54145F | A-54145F is an ester peptide antibiotic produced by Streptomyces fradiae. It has anti-Gram-positive bacteria activity with an MIC of 0.25-32 μg/mL. Synonyms: A-54145 F. Molecular formula: C71H107N17O27. Mole weight: 1630.70. | |
| A 54556A | A 54556A is an unusual depsipeptide antibiotic produced by the strain of streptomyces hawaiiensis. It can inhibit the growth of 786-O, 769-P and ACHN renal carcinoma cells in MTT assay. A 54556A may be a potential chemotherapeutic agent for treatment of renal carcinoma. It has potent activity against gram-positive and gram-negative bacteria, including MRSA. Synonyms: Antibiotic A 54556A; A 54556 factor A; ADEP 1; Acyldepsipeptide 1; Acyldepsipeptide A; N-[[(2E,4E,6E)-1-Oxo-2,4,6-octatrienyl]-L-Phe-]cyclo[L-Ser*-L-Pro-N-methyl-L-Ala-L-Ala-4beta-methyl-L-Pro-]. Grades: >95% by HPLC. CAS No. 95398-45-1. Molecular formula: C38H50N6O8. Mole weight: 718.84. | |
| A-54556B | A-54556B is a natural acyldepsipeptide (ADEP) antibiotic isolated from the fermentation broth of S. hawaiiensis. It has activity against Gram-positive bacteria and many strains of anaerobic bacteria. Synonyms: A-54556 Factor B; Antibiotic A-54556B; N-[(2E,?4E,?6E)?-1-Oxo-2,?4,?6-octatrien-1-yl]?-L-phenylalanyl-L-seryl-L-prolyl-N-methyl-L-alanyl-L-alanyl-L-proline (6?2)?-lactone. Grades: ≥98%. CAS No. 1629166-56-8. Molecular formula: C37H48N6O8. Mole weight: 704.81. | |
| A 58365 A | A58365 A is an enzyme inhibitor produced by Streptomyces chromofuscus A58365.1. It has the effect of inhibiting angiotensin transferase (ACE). Synonyms: 6-Indolizinepropanoic acid, 3-carboxy-1,2,3,5-tetrahydro-8-hydroxy-5-oxo-, (-)-. Grades: >98%. CAS No. 87896-52-4. Molecular formula: C12H13NO6. Mole weight: 267.23. | |
| A 58365 B | A58365 B is an enzyme inhibitor produced by Streptomyces chromofuscus A58365.1. It has the effect of inhibiting angiotensin transferase (ACE). Synonyms: 2H-Quinolizine-7-propanoic acid, 4-carboxy-1,3,4,6-tetrahydro-9-hydroxy-6-oxo-. Grades: >98%. CAS No. 87896-53-5. Molecular formula: C13H15NO6. Mole weight: 281.26. | |
| A 61603 hydrobromide | A 61603 hydrobromide is a potent and selective α-adrenoceptor agonist with 35-fold selectivity for α1A over α1B or α1D sites. Activation of the α1A-adrenergic receptor by A 61603 induces dose response increases in spontaneous Ca2+ transients in rat ventricular myocytes in vitro (EC50 = 6.9 nmol/L). Synonyms: A61603 Hydrobromide; A 61603 Hydrobromide; A-61603 Hydrobromide; N-[5-(4,5-Dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide hydrobromide. CAS No. 107756-30-9. Molecular formula: C14H19N3O3S.HBr. Mole weight: 390.29. | |
| A66 | Inhibition of p110α alone by A66 treatment is sufficient to block insulin signalling to Akt/PKB in certain cell lines that harbor H1047R mutations in PIK3CA and have high levels of p110α and class-Ia PI3K activity. Synonyms: A66; A-66; A 66. Grades: >98%. CAS No. 1166227-08-2. Molecular formula: C17H23N5O2S2. Mole weight: 393.53. | |
| A-674563 | A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC. Synonyms: A674563; A 674563; Benzeneethanamine, α-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-, (αS)-; (α S) -α - [ [ [5- (3-Methyl-1H-indazol-5-yl) -3-pyridinyl] oxy] methyl] benzeneethanamine; (S)-1-((5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl)oxy)-3-phenylpropan-2-amine. Grades: >98%. CAS No. 552325-73-2. Molecular formula: C22H22N4O. Mole weight: 358.44. | |
| A 68930 hydrochloride | A 68930 hydrochloride is a potent and selective dopamine D1-like receptor agonist (EC50 = 2.1 and 3910 nM for D1-like and D2-like receptors, respectively). Synonyms: A-68930 hydrochloride; A 68930 hydrochloride; A68930 hydrochloride; cis-(±)-1-(Aminomethyl)-3,4-dihydro-3-phenyl-1H-2-benzopyran-5,6-diol hydrochloride; (1R,3S)-1-(aminomethyl)-3-phenyl-3,4-dihydro-1H-isochromene-5,6-diol hydrochloride. Grades: ≥98% by HPLC. CAS No. 130465-39-3. Molecular formula: C16H17NO3.HCl. Mole weight: 307.78. | |
| A 71915 | A 71915 is a highly potent and competitive natriuretic peptide receptor A (NPRA) antagonist (pKi = 9.18). Synonyms: (Arg6,β-cyclohexyl-Ala8,D-Tic16,Arg17,Cys18)-Atrial Natriuretic Factor (6-18) amide (mouse, rabbit, rat); H-Arg-Cys-β-cyclohexyl-Ala-Gly-Gly-Arg-Ile-Asp-Arg-Ile-D-Tic-Arg-Cys-NH2 (Disulfide bridge: Cys2-Cys13); L-Cysteinamide, L-arginyl-L-cysteinyl-3-cyclohexyl-L-alanylglycylglycyl-L-arginyl-L-isoleucyl-L-α-aspartyl-L-arginyl-L-isoleucyl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-arginyl-, cyclic(2?13)-disulfide. Grades: ≥95%. CAS No. 132956-87-7. Molecular formula: C69H116N26O15S2. Mole weight: 1613.95. | |
| A-72363 A1 | A-72363 A1 is a Heparanase inhibitor produced by Streptomyces nobilis SANK 60192. Synonyms: A-72363 A-1; 4alpha,5beta-Dihydroxy-6beta-(acetylamino)piperidine-3alpha-carboxylic acid. Molecular formula: C8H14N2O5. Mole weight: 218.21. | |
| A-72363 A2 | A-72363 A2 is a Heparanase inhibitor produced by Streptomyces nobilis SANK 60192. Synonyms: A-72363 A-2; 4beta,5beta-Dihydroxy-6beta-(acetylamino)piperidine-3alpha-carboxylic acid. Molecular formula: C8H14N2O5. Mole weight: 218.21. | |
| A-72363 C | A-72363 C is a Heparanase inhibitor produced by Streptomyces nobilis SANK 60192. Synonyms: A-72363; 4alpha,5alpha-Dihydroxy-6alpha-(acetylamino)piperidine-3alpha-carboxylic acid. Molecular formula: C8H14N2O5. Mole weight: 218.21. | |
| A-75943 | A-75943 is is a bone resorption inhibitor produced by Streptomyces sp. SANK61296. In vitro tests, it has the effect of inhibiting bone resorption with IC50 of 0.35 μmol/L. It also inhibits the bone resorption in rats with thyroid and parathyroidectomy. Synonyms: 2H-Pyran-4-acetamide, 2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)tetrahydro-6-oxo-, (2R,4S)-. Grades: >98%. CAS No. 201215-10-3. Molecular formula: C15H23NO4. Mole weight: 281.35. | |
| A-77-01 | A-77-01 is an inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5( IC50 =25nM). Uses: Potent alk5 inhibitor. Synonyms: A77-01; A 77-01; A-77-01. 4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-quinoline;4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-quinoline. Grades: ≥98%. CAS No. 607737-87-1. Molecular formula: C18H14N4. Mole weight: 286.34. | |
| A 77636 hydrochloride | A 77636 hydrochloride is a potent and selective dopamine D1-like receptor agonist (pEC50 = 8.97 and < 5 for D1-like and D2-like receptors, respectively). A 77636 exhibits anti-Parkinsonian activity following oral administration in vivo. Uses: Potential treatment of neurological disorders. Synonyms: A-77636 hydrochloride; A77636 hydrochloride; A77636 hydrochloride; (1R-cis)-1-(Aminomethyl)-3,4-dihydro-3-tricyclo[3.3.1.13,7]dec-1-yl-[1H]-2-benzopyran-5,6-diol hydrochloride. Grades: ≥98% by HPLC. CAS No. 145307-34-2. Molecular formula: C20H27NO3.HCl. Mole weight: 365.9. | |
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