BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Abemaciclib-[d7] | Labelled Abemaciclib. Abemaciclib is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. It is used for the treatment of advanced or metastatic breast cancers. Synonyms: N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine-d7. Grades: > 98%. Molecular formula: C27H25D7F2N8. Mole weight: 513.64. |  |
| abemaciclib mesylate | Abemaciclib mesylate is a CDK inhibitor with selectivity for CDK4 and CDK6. It was approved for the treatment of advanced or metastatic breast cancers. Uses: The treatment of advanced or metastatic breast cancers. Synonyms: Verzenio; LY2835219; LY 2835219; LY-2835219; UNII-KKT462Q807; Abemaciclib methanesulfonate; N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine methanesulfonate. CAS No. 1231930-82-7. Molecular formula: C28H36F2N8O3S. Mole weight: 602.706. | |
| Abexinostat | Abexinostat, also known as PCI-24781 or CRA-024781, is a novel, broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. Abexinostat inhibits several isoforms of HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling. Synonyms: CRA-024781; CRA 024781; CRA024781; PCI-24781; PCI24781; PCI 24781. Grades: 98%. CAS No. 783355-60-2. Molecular formula: C21H23N3O5. Mole weight: 397.431. | |
| ABH | ABH is an inhibitor of arginase types I and II. Synonyms: Amino-2-borono-6-hexanoic acid; (S)-2-amino-6-boronohexanoic acid. Grades: ≥90%. CAS No. 222638-65-5. Molecular formula: C6H14BNO4. Mole weight: 175. | |
| ABI-010 | ABI-010 is the nanoparticle albumin-bound 17-AAG. Synonyms: ABI-010; ABI 010; ABI010. | |
| Abierixin | Abierixin is a polyether antibiotic isolated from Streptomyces albus NRRL B-1865. Abierixin exhibited weak antimicrobial and ionophorous activities, low toxicity but good anticoccidial activity. Synonyms: Nigericin, 3,7-deepoxy-2,3-didehydro-7-hydroxy-; (2E)-7-hydroxy-8-(2-{5'-[6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl]-2,3'-dimethyloctahydro-2,2'-bifuran-5-yl}-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]dec-7-yl)-2,4-dimethyloct-2-enoic acid. CAS No. 100634-16-0. Molecular formula: C40H68O11. Mole weight: 724.96. | |
| Abiesinol F | Abiesinol F isolated from the herbs of Abies ernestii. Synonyms: 2''-epi-Abiesinol E. Grades: > 95%. CAS No. 1190070-91-7. Molecular formula: C30H22O10. Mole weight: 542.5. | |
| Abiraterone | Abiraterone blocks the synthesis of androgens by inhibiting CYP17A1. It is used to treat metastatic, castration-resistant prostate cancer. Uses: The treatment of metastatic, castration-resistant prostate cancer. Synonyms: (3beta)-17-(3-pyridinyl)-androsta-5,16-dien-3-ol; 17-(3-Pyridyl)androsta-5,16-dien-3beta-ol; CB 7598; CB-7598; CB7598. Grades: >98%. CAS No. 154229-19-3. Molecular formula: C24H31NO. Mole weight: 349.51. | |
| Abiraterone Acetate-5,6-Epoxide | Abiraterone Acetate-5,6-Epoxide is an impurity of Abiraterone acetate. Abiraterone acetate is a CYP17A1 inhibitor and by extension androgen synthesis inhibitor. Synonyms: (3S, 4aR, 5aS, 6aS, 6bS, 9aS, 11aS, 11bR)-9a, 11b-dimethyl-9-(pyridin-3-yl)-1, 2, 3, 4, 5a, 6, 6a, 6b, 7, 9a, 10, 11, 11a, 11b-tetradecahydrocyclopenta[1, 2]phenanthro[8a, 9-b]oxiren-3-yl acetate; (3β,5α,6α)-5,6-epoxy-17-(3-pyridinyl)-3-androst-16-en-3-ol-3-acetate. CAS No. 1868064-50-9. Molecular formula: C26H33NO3. Mole weight: 407.55. | |
| Abiraterone Acetate N-Oxide | Abiraterone Acetate N-Oxide is an impurity of Abiraterone acetate. Abiraterone acetate is a CYP17A1 inhibitor and by extension androgen synthesis inhibitor. Synonyms: 3-((3S,8R,9S,10R,13S,14S)-3-acetoxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)pyridine 1-oxide. CAS No. 2517964-85-9. Molecular formula: C26H33NO3. Mole weight: 407.55. | |
| Abiraterone Ethyl Ether | Abiraterone Ethyl Ether is an impurity of Abiraterone acetate. Abiraterone acetate is a CYP17A1 inhibitor and by extension androgen synthesis inhibitor. Synonyms: 3-((3S,8R,9S,10R,13S,14S)-3-ethoxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)pyridine. CAS No. 2484719-14-2. Molecular formula: C26H35NO. Mole weight: 377.56. | |
| Abiraterone Impurity 1 | Cas No. 853-23-6. | |
| Abiraterone Related Compound 1 (Pregnenolone-16-ene Acetate) | Cas No. 979-02-2. | |
| Abiraterone Related Compound 2 | A related compound of Abiraterone. Synonyms: (5α)-17-(3-Pyridinyl)androst-16-en-3-one; Abiraterone Impurity 2. Grades: > 95%. CAS No. 154229-26-2. Molecular formula: C24H31NO. Mole weight: 349.52. | |
| Abiraterone Related Compound 3 (Pregnenolone-16-ene Acetate Oxime) | Pregnenolone-16-ene Acetate Oxime is used in the synthesis of pegnange derivatives as antioxidant and anti-dyslipidemic agents. Synonyms: Abiraterone Impurity 3,Pregnenolone-16-ene Acetate Oxime. Grades: > 95%. CAS No. 2174-13-2. Molecular formula: C23H33NO3. Mole weight: 371.52. | |
| Abiraterone Related Compound 4 (Prasterone Acetate Triflate) | An impurity of Abiraterone, a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. Synonyms: Abiraterone Impurity 4, Prasterone Acetate Triflate. Grades: > 95%. CAS No. 115375-60-5. Molecular formula: C22H29F3O5S. Mole weight: 462.53. | |
| Abiraterone Related Compound 7 | An impurity of Abiraterone , a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor. Synonyms: Abiraterone Impurity 7. Grades: > 95%. Molecular formula: C47H61NO4. Mole weight: 704.01. | |
| ABL 127 | ABL 127 is a covalent aza-β-lactam inhibitor of protein phosphatase methylesterase-1 (PME-1; IC50 = 4.2 nM). Grades: ≥98%. CAS No. 1073529-41-5. Molecular formula: C17H20N2O5. Mole weight: 332.4. | |
| Abl Cytosolic Substrate | Abl Cytosolic Substrate is a substrate for Abelson tyrosine kinase (Abl). Synonyms: L-Lysine, L-α-glutamyl-L-alanyl-L-isoleucyl-L-tyrosyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alanyl-L-lysyl-L-lysyl-; L-Lysine, N2-[N2-[N2-[N-[N-[1-[N-[N-[N-[N-(N-L-α-glutamyl-L-alanyl)-L-isoleucyl]-L-tyrosyl]-L-alanyl]-L-alanyl]-L-prolyl]-L-phenylalanyl]-L-alanyl]-L-lysyl]-L-lysyl]-; L-α-Glutamyl-L-alanyl-L-isoleucyl-L-tyrosyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alanyl-L-lysyl-L-lysyl-L-lysine; Glu-Ala-Ile-Tyr-Ala-Ala-Pro-Phe-Ala-Lys-Lys-Lys. Grades: ≥95%. CAS No. 168202-46-8. Molecular formula: C64H101N15O16. Mole weight: 1336.58. | |
| AB-MECA | AB-MECA, a adenosine derivative, is a high affinity human A3 receptor in HEK 293 cells agonist. Synonyms: (2S,3S,4R,5R)-5-[6-[(4-aminophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamideABMECA; AB MECA; AB-MECA152918-26-8N6-(4-Aminobenzyl)-N-methylcarboxamidoadenosine(2S, 3S, 4R, 5R)-5-[6-[(4-aminophenyl)methylamino]purin-9-yl]-3, 4-dihydroxy-N-methyloxo. CAS No. 152918-26-8. Molecular formula: C18H21N7O4. Mole weight: 399.40. | |
| a,b-Methyleneguanosine 5'-diphosphate sodium salt | a,b-Methyleneguanosine 5'-diphosphate sodium salt, as a fundamental chemical compound, finds wide applications in the biomedical sector due to its therapeutic potential across diverse diseases. With its significant contribution to vital cellular mechanisms and signal transduction pathways, this compound essentially facilitates the synthesis and metabolism of guanosine triphosphate, a pivotal molecule implicated in numerous biological processes. Synonyms: GMPCP; GPCP. Molecular formula: C11H17N5O10P2·xNa. Mole weight: 441.23 (free acid). | |
| Abn-CBD | Abn-CBD is a neurobehaviorally inactive cannabinoid and acts as a selective and potent agonist for GPR55 with EC50 value of 2.5 μM. It increases migration and phosphorylation of protein kinases in human umbilical vein endothelial cells. Synonyms: 1,3-Benzenediol, 4-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-; 1,3-Benzenediol, 4-[3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-, trans-(-)-; 4-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol; Resorcinol, 4-p-mentha-1,8-dien-3-yl-5-pentyl-, trans-(-)-; Abnormal Cannabidiol; (1'R,2'R)-5'-methyl-6-pentyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydro-[1,1'-biphenyl]-2,4-diol; trans-(-)-4-p-Mentha-1,8-dien-3-yl-5-pentylresorcinol; trans-(-)-4-[3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol. Grades: ≥97% by HPLC. CAS No. 22972-55-0. Molecular formula: C21H30O2. Mole weight: 314.47. | |
| Abrocitinib | Abrocitinib is a seletive JAK1 inhibitor with IC50 value of 29 nM. Abrocitinib has been investigated for the treatment of plaque psoriasis. Synonyms: PF-04965842; N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide. Grades: >98%. CAS No. 1622902-68-4. Molecular formula: C14H21N5O2S. Mole weight: 323.415. | |
| (+)-Abscisic acid | Abscisic acid is a plant hormone, which is involved in many plant developmental processes, modulating ion homeostasis and metabolism, and inhibiting germination and seedling growth. Uses: Plant growth regulators. Synonyms: (S)-(+)-Abscisic acid. Grades: ≥98% by HPLC. CAS No. 21293-29-8. Molecular formula: C15H20O4. Mole weight: 264.32. | |
| ABT 089 dihydrochloride | ABT 089 dihydrochloride is a selective α4β2 nicotinic acetylcholine receptor partial agonist (Ki = 16 nM) with >1000-fold and >10,000-fold selectivity for α4β2 over α1β1γ1 and α7 receptors, respectively. ABT 089 dihydrochloride is used as a nootropic and neuroprotective agent. Uses: Nootropic and neuroprotective agent. Synonyms: ABT 089 dihydrochloride; ABT089 dihydrochloride; ABT-089 dihydrochloride; 2-Methyl-3-[(2S)-pyrrolidinylmethoxy]pyridine dihydrochloride; Pozanicline hydrochloride. Grades: ≥98% by HPLC. CAS No. 161416-61-1. Molecular formula: C11H16N2O.2HCl. Mole weight: 265.18. | |
| ABT-102 | ABT 102 is a selective transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with IC50 values to be 5-7 nM. No recent reports of development identified for phase-I development in Pain in USA. Uses: Pain. Synonyms: ABT 102; ABT-102; ABT102; CHEMBL398338; 1-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-3-(1H-indazol-4-yl)urea. Grades: 98%. CAS No. 808756-71-0. Molecular formula: C21H24N4O. Mole weight: 348.44. | |
| ABT116 | ABT116 is an antagonist of transient receptor potential vanilloid type 1. Synonyms: ABT-116; ABT 116; ABT116; 1-[[2-(3,3-dimethylbutyl)-4-(trifluoromethyl)phenyl]methyl]-3-(1-methylindazol-4-yl)urea. Grades: >98 %. CAS No. 1008529-42-7. Molecular formula: C23H27F3N4O. Mole weight: 432.49. | |
| ABT-20 | ABT-202, a small molecule, asts as an agonist at neural nicotinic acetylcholine receptors. Uses: An agonist at neural nicotinic acetylcholine receptors and has been researched for use as an analgesic. Synonyms: ABT-202; ABT 202; ABT202; (3R)-1-(Pyridin-3-yl)pyrrolidin-3-amine. Grades: ≥98%. CAS No. 309959-34-0. Molecular formula: C9H13N3. Mole weight: 163.22. | |
| ABT-239 | ABT-239 is a novel, highly efficacious, non-imidazole class of H3R antagonist has been investigated as a treatment for ADHD, Alzheimer's disease, and schizophrenia. Uses: H3-receptor inverse agonist. Synonyms: ABT-239; ABT 239; ABT239; 4-(2-{2-[(2R)-2-Methylpyrrolidin-1-yl]ethyl}- benzofuran-5-yl)benzonitrile. Grades: ≥98%. CAS No. 460746-46-7. Molecular formula: C22H22N2O. Mole weight: 330.42. | |
| ABT-255 | ABT-255, a novel 2-pyridone antibacterial agent, is an analog of ABT-719 with improvements in the therapeutic margin against common gram-positive and -negative bacterial infections. ABT-255 demonstrated in vitro potency and in vivo efficacy against both drug-susceptible and drug-resistant M. tuberculosis strains. Synonyms: 8-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxoquinolizine-3-carboxylic acid; ABT255; ABT 255; ABT-255; 186293-38-9; UNII-IMA7HK8V8X; 181141-52-6 (hydrochloride salt). Grades: >98%. CAS No. 186293-38-9. Molecular formula: C21H24FN3O3. Mole weight: 385.439. | |
| ABT 29666 | ABT 29666 is a therapeutic agent. Uses: A therapeutic agent. Synonyms: ABT 29666; ABT29666; ABT-29666; Piperidine, 1-(3-((4-((p-chlorophenyl)azo)-5,6,7,8-tetrahydro-1-naphthyl)amino)propyl)-. Grades: ≥98%. CAS No. 3365-99-9. Molecular formula: C24H31ClN4. Mole weight: 410.22. | |
| ABT 38396 | ABT 38396 is a synthetic bio-active chemical. Uses: A synthetic bio-active chemical. Synonyms: ABT 38396; ABT38396; ABT-38396; N-(5,6,7,8-tetrahydro-4-((6-methoxy-3-pyridinyl)azo)-1-naphthalenyl)-1-Piperidinepropanamine. Grades: ≥95%. CAS No. 4853-98-9. Molecular formula: C24H33N5O. Mole weight: 407.55. | |
| ABT-510 | ABT-510 is a synthetic peptide that mimics the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1). ABT-510 inhibits the actions of several pro-angiogenic growth factors important to tumor neovascularization; these pro-angiogenic growth factors include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF)), hepatocyte growth factor (HGF), and interleukin 8 (IL-8). Synonyms: ABT-510; ABT 510; ABT510. CAS No. 251579-55-2. Molecular formula: C46H83N13O11. Mole weight: 994.25. | |
| ABT-515 | ABT-515 is a formidable and discriminative antagonist exhibiting its capability by selectively inhibiting particular enzymes crucial in the advancement of malignant neoplasms. Synonyms: 1-[(2R)-4-[5-[(4-fluorophenyl)-hydroxymethyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxyurea; ABT-515; 189328-52-7; ABT-515; UNII-186W5U73P9; ABT 515; ABT515. Grades: >98%. CAS No. 189328-52-7. Molecular formula: C16H15FN2O3S. Mole weight: 334.37. | |
| ABT-594 | ABT-594, also called as Tebanicline, the (R)-enantiomer of A-98593, is a potent synthetic non-opioid nicotinic analgesic drug. ABT-594 is a novel nAChR ligan which is shown to exert potent analgesic action in models of nociceptive and persistent pain and to possess substantially reduced activity at peripheral nAChRs. Synonyms: 5-[[(2R)-azetidin-2-yl]methoxy]-2-chloropyridine; Tebanicline; ABT-594; ABT 594; ABT594; Ebanicline. CAS No. 198283-73-7. Molecular formula: C9H11ClN2O. Mole weight: 198.65. | |
| ABT-639 | ABT-639, a new blocker of selective T-type Ca2+ channel blocker, has been found to have potential effect against neuropathic and nociceptive pain in studies. It has already been discontinued in the treatment of diabetic neuropathies. Uses: Abt-639 is a new blocker of selective t-type ca2+ channel blocker that has been found to have potential effect against neuropathic and nociceptive pain in studies. Synonyms: ABT-639; ABT 639; ABT-639 free base; UNII-0G7D0CQ88I; SCHEMBL400073; 0G7D0CQ88I. Grades: 98%. CAS No. 1235560-28-7. Molecular formula: C20H20ClF2N3O3S. Mole weight: 455.91. | |
| ABT 702 | ABT 702 is a non-nucleoside adenosine kinase (ADK) inhibitor (IC50 = 2 nM and 50 nM in cytosolic and intact cell assays, respectively). Study conformed that ABT702 could reduce pain and inflammation in animal models, yet be clastogenic in an in vitro Chinese Hamster micronucleus assay. Synonyms: ABT 702; ABT702; ABT-702; 5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine. Grades: 99%. CAS No. 214697-26-4. Molecular formula: C22H19BrN6O. Mole weight: 463.33. | |
| ABT 702 Dihydrochloride | ABT 702 Dihydrochloride is a potent and selective non-nucleoside adenosine kinase inhibitor with IC50 value of 1.7 nM. ABT 702 displays oral activity in animal models of pain and inflammation. In Mar 2005, ABT 702 was discontinued preclinical for Pain and Rheumatoid arthritis in USA. Uses: Anti-inflammation. Synonyms: ABT702 Dihydrochloride; ABT-702 Dihydrochloride. Grades: 98%. CAS No. 1188890-28-9. Molecular formula: C22H21BrCl2N6O. Mole weight: 536.26. | |
| ABT-719 | ABT-719, a fluoroquinolone derivative, has been found to be a DNA topoisomerase inhibitor that was once developed in antibacterial studies. Synonyms: ABT-719; ABT719; ABT 719; ABT-719; A-816719.1; A 816719.1; A816719.1; (R)-8-(3-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid. Grades: 98%. CAS No. 162829-90-5. Molecular formula: C18H20FN3O3. Mole weight: 345.23. | |
| ABT-719 HCl | The hydrochloride salt form of ABT-719, a fluoroquinolone derivative, has been found to be a DNA topoisomerase inhibitor that was once developed in antibacterial studies. Synonyms: ABT-719 HCl; ABT719 HCl; ABT 719 HCl; ABT-719 hydrochloride; A-816719.1; A 816719.1; A816719.1; (R)-8-(3-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid hydrochloride. Grades: 98%. CAS No. 162763-53-3. Molecular formula: C18H21ClFN3O3. Mole weight: 381.83. | |
| ABT 724 trihydrochloride | ABT 724 trihydrochloride is a potent dopamine D4 receptor partial agonist (EC50 = 12.4 nM; 61% efficacy vs. dopamine) for treatment of sexual dysfunction. Synonyms: 2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole trihydrochloride; ABT-724 trihydrochloride; ABT724 trihydrochloride; ABT 724 trihydrochloride. Grades: ≥99% by HPLC. CAS No. 587870-77-7. Molecular formula: C17H19N5.3HCl. Mole weight: 402.75. | |
| ABT-737 | ABT-737 is a potent, cell-permeable mimetic of BH3 domains that avidly binds Bcl-2, Bcl-xL, and Bcl-W (Ki < 1 nM for all three proteins). It blocks the interaction of these proteins with pro-death proteins, leading to apoptosis. Synonyms: ABT 737; ABT-737; ABT737. CAS No. 852808-04-9. Molecular formula: C42H45ClN6O5S2. Mole weight: 813.43. | |
| ABT 737-[d8] | Labelled ABT-737. ABT-737 is a potent, cell-permeable mimetic of BH3 domains that avidly binds Bcl-2, Bcl-xL, and Bcl-W (Ki < 1 nM for all three proteins). It blocks the interaction of these proteins with pro-death proteins, leading to apoptosis. Synonyms: 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide-d8. CAS No. 1217686-68-4. Molecular formula: C42H37D8ClN6O5S2. Mole weight: 821.48. | |
| ABT 751 | ABT 751, also called E7010, is a novel bioavailable tubulin-binding and antimitotic agent that inhibits microtubule polymerization (in neuroblastoma: IC50 = 0.6-2.6 μM; in non-neuroblastoma cell lines: IC50 = 0.7-4.6 μM). Synonyms: N-[2-(4-hydroxyanilino)pyridin-3-yl]-4-methoxybenzenesulfonamide; E 7010; E-7010; E7010; N-(2-((4-hydroxyphenyl)amino)-3-pyridinyl)-4-methoxybenzenesulfonamide; ABT-751; 141430-65-1; ABT 751; E-7010; ABT751; UNII-WDT5V5OB9F; E 7010; WDT5V5OB9F; CHEMBL20684. CAS No. 141430-65-1. Molecular formula: C18H17N3O4S. Mole weight: 371.41. | |
| ABT-888 | Veliparib dihydrochloride is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. Synonyms: ABT-888; ABT 888; ABT888. CAS No. 912445-05-7. Molecular formula: C13H18Cl2N4O. Mole weight: 317.21. | |
| ABTL-0812 | ABTL-0812 is an orally bioavailable, lipid analogue and inhibitor of raptor-mammalian target of rapamycin (mTOR), rictor-mTOR and dihydrofolate reductase with potential antineoplastic activity. It binds to and inhibits both mTORC1 and mTORC2, which may result in apoptosis and a decrease in proliferation in mTORC1/2-expressing tumor cells upon oral administration. It was developed by Ability Pharmaceuticals and is in phase I/II clinical trials for the treatment of solid tumors. It received orphan drug designation in the E.U. and in the U.S. for the treatment of neuroblastoma in 2015. Uses: Abtl-0812 has potential antineoplastic activity. it is used for the treatment of solid tumors. Synonyms: ABTL0812; ABTL 0812; ABTL-0812; (9Z,12Z)-2-hydroxyoctadeca-9,12-dienoate. Grades: 98%. CAS No. 57818-44-7. Molecular formula: C18H31O3. Mole weight: 294.93. | |
| a,b-Trehalose | a,b-Trehalose is a naturally occurring disaccharide, holding significant importance in the biomedical industry due to its extensive utilization. This multifaceted compound serves as a stabilizer for proteins, enzymes and vaccines, showcasing its diversity. Moreover, a,b-Trehalose exhibits promising potential in studying neurodegenerative conditions, specifically Parkinson's and Alzheimer's diseases. Synonyms: Neotrehalose a-D-Glucopyranosyl b-D-glucopyranoside. CAS No. 585-91-1. Molecular formula: C12H22O11. Mole weight: 342.3. | |
| Abu-Gly-OH | Synonyms: 2-Amino-N-butyric acid glycine. Grades: ≥ 98% (HPLC). CAS No. 16305-80-9. Molecular formula: C6H12N2O3. Mole weight: 160.17. | |
| ABX-1431 | ABX-1431 is an inhibitor of monoacylglycerol lipase (MAGL; IC50s = 14 and 27 nM for human and rat enzyme, respectively). Synonyms: 1,1,1,3,3,3-hexafluoropropan-2-yl 4-[[2-pyrrolidin-1-yl-4- (trifluoromethyl) phenyl]methyl]piperazine-1-carboxylate. Grades: ≥98%. CAS No. 1446817-84-0. Molecular formula: C20H22F9N3O2. Mole weight: 507.3. | |
| Abz-FR-K(Dnp)-P-OH | An angiotensin I-converting enzyme (ACE) substrate and an internally quenched fluorogenic substrate for real time fluorescent assay. Synonyms: H-2Abz-Phe-Arg-Lys(Dnp)-Pro-OH; N-(2-Aminobenzoyl)-L-phenylalanyl-L-arginyl-N6-(2,4-dinitrophenyl)-L-lysyl-L-proline; o-Aminobenzoic acid-FRK(Dnp)P-OH; Abz-FR-K (Dnp)-P. Grades: ≥95%. CAS No. 500799-61-1. Molecular formula: C39H49N11O10. Mole weight: 831.87. | |
| AC 187 | AC 187 is a potent amylin receptor antagonist (IC50 = 0.48 nM) displaying 38- and 400-fold selectivity over calcitonin and CGRP receptors respectively. It inhibits amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. It increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo. Synonyms: Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2; N-acetyl-L-valyl-L-leucyl-glycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparagyl-L-threonyl-glycyl-L-seryl-L-asparagyl-L-threonyl-L-tyrosinamide; AC187; salmon calcitonin (8-32) reduced; acetyl-(Asn30,Tyr32)sCT(8-37); AC-187. Grades: >98%. CAS No. 151804-77-2. Molecular formula: C127H205N37O40. Mole weight: 2890.25. | |
| Ac2-12 | Ac2-12 is an annexin/lipocortin 1-mimetic peptide that inhibits leukocyte extravasation. It promotes detachment of neutrophils from activated mesenteric endothelium in mice in vivo. It reduces neutrophil adhesion and emigration. It has an anti-inflammatory effect. Synonyms: LPC1; ANX1; ANXA-1. CAS No. 256447-08-2. Molecular formula: C63H94N14O17S. Mole weight: 1351.58. | |
| AC 220 dihydrochloride | AC 220 dihydrochloride is a potent and selective inhibitor of FMS-like tyrosine kinase-3 (FLT3) used for the treatment of AML. Uses: The treatment of aml. Synonyms: AC 220 dihydrochloride; AC220 dihydrochloride; AC-220 dihydrochloride; Quizartinib dihydrochloride; 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[6-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl]urea dihydrochloride. Grades: 98%. CAS No. 1132827-21-4. Molecular formula: C29H32N6O4S.2HCl. Mole weight: 633.59. | |
| Ac2-26 | Ac2-26 is an annexin/lipocortin 1-mimetic peptide that inhibits leukocyte extravasation. It promotes detachment of neutrophils from activated mesenteric endothelium and accelerates epithelial wound repair after induced colonic injury in mice in vivo. It reduces neutrophil adhesion and emigration. It has an anti-inflammatory effect. Synonyms: Annexin-1 (2-26) (human); Ac2-26; Lipocortin-1 (2-26); Calpactin II (1-25) (dephosphorylated) (human); Annexin A1 (1-25) (dephosphorylated) (human); Annexin A1 (1-25) (dephosphorylated) (human); Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys-OH. Grades: >98%. CAS No. 151988-33-9. Molecular formula: C141H210N32O44S. Mole weight: 3089.43. | |
| Ac2-26 TFA | Ac2-26 TFA is an annexin/lipocortin 1-mimetic peptide that inhibits leukocyte extravasation. It promotes detachment of neutrophils from activated mesenteric endothelium and accelerates epithelial wound repair after induced colonic injury in mice in vivo. It reduces neutrophil adhesion and emigration. It has anti-inflammatory effect. Synonyms: Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys.TFA; Annexin A1 (1-25) (dephosphorylated) (human).TFA; L-Lysine, N-acetyl-L-alanyl-L-methionyl-L-valyl-L-seryl-L-α-glutamyl-L-phenylalanyl-L-leucyl-L-lysyl-L-glutaminyl-L-alanyl-L-tryptophyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-asparaginyl-L-α-glutamyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-tyrosyl-L-valyl-L-glutaminyl-L-threonyl-L-valyl-, trifluoroacetic acid. Grades: ≥95%. Molecular formula: C143H211F3N32O46S. Mole weight: 3203.45. | |
| AC 253 | AC 253 is an amylin (AMY3) receptor antagonist. It inhibits andrenomedulin-stimulated cAMP production in vitro. Synonyms: L-Tyrosinamide, N-acetyl-L-leucylglycyl-L-arginyl-L-leucyl-L-seryl-L-glutaminyl-L-a-glutamyl-L-leucyl-L-histidyl-L-arginyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparaginyl-L-threonylglycyl-L-seryl-L-asparaginyl-L-threonyl-. Grades: ≥95%. CAS No. 151804-79-4. Molecular formula: C122H196N40O39. Mole weight: 2847.11. | |
| AC 261066 | AC 261066 is a potent RARβ2 agonist (pEC50 = 8.1). Synonyms: AC261066; AC-261066; 4-[4-(2-Butoxyethoxy-)-5-methyl-2-thiazolyl]-2-fluorobenzoic acid; Benzoic acid, 4-[4-(2-butoxyethoxy)-5-methyl-2-thiazolyl]-2-fluoro-. Grades: 98%. CAS No. 870773-76-5. Molecular formula: C17H20FNO4S. Mole weight: 353.41. | |
| AC 264613 | AC 264613 is a potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 7.5). AC 264613 inhibits interferon regulatory factor 5 and decreases interleukin-12p40 production via lipopolysaccharide-stimulated macrophages. PI hydrolysis, Ca2+ mobilization and cellular proliferation are activated by AC 264613 in vitro (pEC50 = 6.9, 7.0 and 7.5, respectively). Synonyms: AC-264613; AC 264613; AC264613; (±)-(3R,4S)-2-Oxo-4-phenyl-3-pyrollidinecarboxylic acid 2-[1-(3-bromophenyl)ethylidene]hydrazide. Grades: ≥98% by HPLC. CAS No. 1051487-82-1. Molecular formula: C19H18BrN3O2. Mole weight: 400.27. | |
| Ac-2-Nal-OH | Synonyms: (S)-N-ACETYL-2-NAPHTHYLALANINE; (S)-2-Acetamido-3-(naphthalen-2-yl)propanoic acid. Grades: ≥ 95%. CAS No. 37439-99-9. Molecular formula: C15H15NO3. Mole weight: 257.3. | |
| AC 41848 | AC 41848 is a potent, cell permeable, and subtype selective retinoic acid receptor RARγ agonist with an EC50 of 5.9 μM. Synonyms: 1-[(2,4-Dichlorophenyl)methyl]-6,7,8,9-tetrahydro-3-phenyl-5H-imidazo[1,2-a]azepinium Bromide; 1-(2,4-Dichlorobenzyl)-3-phenyl-1,5,6,7,8,9-hexahydroimidazo[1,2-a]azepin-4-ium bromide; 5H-Imidazo[1,2-a]azepinium, 1-[(2,4-dichlorophenyl)methyl]-6,7,8,9-tetrahydro-3-phenyl-, bromide (1:1). Grades: ≥98%. CAS No. 400856-69-1. Molecular formula: C21H21BrCl2N2. Mole weight: 452.21. | |
| Ac-4,5-dehydro-L-leucine | Synonyms: Ac-4,5-dehydro-L-Leu-OH; Ac-4,5-dehydro-leu-oh; (S)-2-Acetamido-4-methylpent-4-enoic acid; Ac-4,5-dehydro-Leu-OH; N-alpha-Acetyl-4,5-dehydro-L-leucine; (2S)-2-ACETAMIDO-4-METHYLPENT-4-ENOIC ACID; 4-Pentenoic acid, 2-(acetylamino)-4-methyl-, (S)-(9ci). Grades: ≥ 99% (TLC). CAS No. 88547-24-4. Molecular formula: C8H13NO3. Mole weight: 171.20. | |
| AC480 | AC480, also known as BMS-599626, is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50 =22, 32 and 190 nM, respectively) with potential antineoplastic activity. BMS-599626 inhibits human epidermal growth factor receptors (HER) HER1, HER2 and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. Synonyms: BMS-599626; BMS 599626; BMS599626; AC 480; AC-480; Carbamic acid, N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester; (3S)-3-Morpholinylmethyl N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate; Carbamic acid, [4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester; N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamic acid, (3S)-3-morpholinylmethyl ester. Grades: ≥95%. CAS No. 714971-09-2. Molecular formula: C27H27FN8O3. Mole weight: 530.55. | |
| AC-55541 | AC-55541 is a novel small-molecule protease-activated receptor 2(PAR2) agonist which displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. It activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM. It was well absorbed when administered intraperitoneally to rats, reaching micromolar peak plasma concentrations. It was stable to metabolism by liver microsomes and maintained sustained exposure in rats. Uses: Ac-55541 stimulates cell proliferation, phosphatidylinositol hydrolysis, and calcium mobilization. Synonyms: AC-55541; AC 55541; AC55541. (2E)-2-[1-(3-Bromophenyl)ethylidene]α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineaceticacidhydrazide;AC 55541;alpha-(Benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid (2E)-2-[1-(3-bromophenyl)ethylidene]hydrazide;N-[2-[(2E)-2-[1-(3-bromophenyl)ethylidene]hydrazinyl]-2-oxo-1-(4-oxo-3H-phthalazin-1-yl)ethyl]benzamide. Grades: >97 %. CAS No. 916170-19-9. Molecular formula: C25H20BrN5O3. Mole weight: 518.36. | |
| AC710 | AC710 is a potent, selective platelet-derived growth factor receptor-family kinase inhibitor with potential anticancer activity. AC710 is now a preclinical development candidate. Synonyms: AC 710; AC-710. Grades: >98%. CAS No. 1351522-04-7. Molecular formula: C31H42N6O4. Mole weight: 562.7. | |
| AC710 Mesylate | AC710 Mesylate is a potent, selective PDGFR-family kinases inhibitor with Kd values of 0.6 nM/1.0 nM/1.3 nM/1.0 nM for FLT3/KIT/PDGFRα/PDGFRβ respectively. Synonyms: AC710 Mesylate; AC 710 Mesylate; AC-710 Mesylate. Grades: >98%. CAS No. 1351522-05-8. Molecular formula: C32H46N6O7S. Mole weight: 658.81. | |
| Ac9-25 | Ac9-25 is a N-terminal peptide of Annexin I (AI/Lipocortin I) that inhibits leukocyte extravasation. It stimulates neutrophil NADPH oxidase activation by acting as a formyl peptide receptor 1 (FPR1) ligand. Synonyms: L-Lysine, N2-acetyl-L-glutaminyl-L-alanyl-L-tryptophyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-asparaginyl-L-α-glutamyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-tyrosyl-L-valyl-L-glutaminyl-L-threonyl-L-valyl-; N2-Acetyl-L-glutaminyl-L-alanyl-L-tryptophyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-asparaginyl-L-α-glutamyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-tyrosyl-L-valyl-L-glutaminyl-L-threonyl-L-valyl-L-lysine; Ac-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys-OH. Grades: ≥95%. CAS No. 284040-76-2. Molecular formula: C99H143N23O33. Mole weight: 2183.35. | |
| Acacetin | Acacetin isolated from the bark of Acacia farnesiana. It can inhibit p38 and JNK phosphorylation and reduces MMP-1, MMP-3 and MMP-13 expression in interleukin-1β-induced FLSs. Uses: Anti-inflammatory; anti-plasmodial activity; anti-peroxidant activity; anti-cancer and antitumor activities. Synonyms: 5,7-dihydroxy-4'-methoxyflavone. Grades: 0.985. CAS No. 480-44-4. Molecular formula: C16H12O5. Mole weight: 284.3. | |
| Acacetin 7-O-β-D-Galactopyranoside | Acacetin-7-O-β-D-galactopyranoside, a natural flavonoid isolated from flower heads of Chrysanthemum morifolium, has been reported to inhibit the replication of HIV in H9 cells. Synonyms: 7-(β-D-Galactopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one. CAS No. 80443-15-8. Molecular formula: C22H22O10. Mole weight: 446.40. | |
| Acacia | Gum Arabic is an exudate gum picked from Acacia trees (typically Acacia Senegal and Acacia Laetia) that grow in arid regions. The polysaccharide is branched with a main chain of (1-3) linked β-D-galactopyranosyl units with side chains of (1-3) β-D galactopyranosyl units joined to it by (1-6) links. The side chains are 2-5 units in length. Both the main chain and the side chains have attached units of α-L-arabinofuranosyl, α-L-rhamnopyranosyl, β-D-glucuronopyranosyl and 4-O-methyl-β-D-glucuronopyranosyl units. Uses: Decorative cosmetics. Synonyms: Gum arabic, Acacia, Arabic gum. CAS No. 9000-1-5. Molecular formula: C12H36. Mole weight: 180.41. | |
| Ac-Ala-Ala-OH | Synonyms: Acetylalanylalanine; Ac-D-Ala-D-ala; Acetyl-ala-ala; N-acetylalanylalanine; N-Acetyl-Ala-Ala-OH; Acetyl-D-alanyl-D-alanine; Ac Ala Ala OH. Grades: 95%. CAS No. 19245-87-5. Molecular formula: C8H14N2O4. Mole weight: 202.21. | |
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