MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Itopride N-Oxide | 2-(4-((3, 4-Dimethoxybenzamido)methyl)phenoxy)-N, N-dimethylethan-1-amine oxide is a biological molecule. Uses: Scientific research. Group: Signaling pathways. CAS No. 141996-98-7. Pack Sizes: 1 mg. Product ID: HY-W701323. |  |
| Itraconazole | Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC 50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase ( cytochrome P450 enzyme ), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein ( OSBP ) inhibitor [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: R51211. CAS No. 84625-61-6. Pack Sizes: 100 mg; 500 mg. Product ID: HY-17514. | |
| Iturin A | Iturin A is a cyclic lipid peptide with strong antifungal activity. Iturin A induces ROS explosion and induces apoptosis and autophagy in tumor cells. Iturin A has antitumor activity [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 52229-90-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P2322. | |
| IU1 | IU1 is a special Usp14 inhibitor with an IC 50 of 4-5 μM. Uses: Scientific research. Group: Signaling pathways. CAS No. 314245-33-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13817. | |
| Ivabradine | Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 155974-00-8. Pack Sizes: 1 mg. Product ID: HY-B0162. | |
| Ivabradine hydrochloride | Ivabradine hydrochloride is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine hydrochloride reduces dose-dependently heart rate without modification of blood pressure. Ivabradine hydrochloride shows anticonvulsant, anti-ischaemic and anti-anginal activity [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 148849-67-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-B0162A. | |
| Ivacaftor | Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC 50 s of 100 nM and 25 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VX-770. CAS No. 873054-44-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13017. | |
| Ivacaftor-d19 | Ivacaftor-d 9 is a potent CFTR modulator and exhibits an EC 50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research [1]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: VX-770-d19. CAS No. 1413431-22-7. Pack Sizes: 5 mg; 1 mg. Product ID: HY-13017S1. | |
| Ivarmacitinib | Ivarmacitinib (SHR0302) is a potent and orally active all members of the JAK family inhibitor, particularly JAK1. The selectivity of Ivarmacitinib for JAK1 is >10-fold for JAK2 , 77-fold for JAK3 , 420-fold for Tyk2. Ivarmacitinib inhibits JAK1-STAT3 phosphorylation and induces the apoptosis of hepatic stellate cells. Ivarmacitinib has anti-proliferative and anti-inflammatory effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SHR0302. CAS No. 1445987-21-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112724. | |
| Ivermectin | Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X 4 and the α7 neuronal nicotinic acetylcholine receptor ( nAChRs ). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import [1] [2] [3] [4]. Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 [5]. Uses: Scientific research. Group: Natural products. Alternative Names: MK-933; CD-5024; K-237. CAS No. 70288-86-7. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-15310. | |
| Ivermectin B1a | Ivermectin B1a, a derivative of Avermectin B1a (HY-15308), is a main component of Ivermectin (HY-15310) [1]. Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 71827-03-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-126937. | |
| Ivonescimab | Ivonescimab (AK112) is a PD-1 / VEGF Bispecific Antibody. Ivonescimab can be used for cancer research [1] [2] [3]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: AK112. CAS No. 2428381-53-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99675. | |
| Ivosidenib | Ivosidenib (AG-120) is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme , it exhibits profound d-2-hydroxyglutatrate (2-HG) lowering in vivo. Ivosidenib (AG-120) has the potential for AML therapy due to its acceptable safety profile and clinical activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AG-120. CAS No. 1448347-49-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18767. | |
| Ivospemin | Ivospemin (SBP-101) is an antineoplastic spermine analog. Ivospemin has shown efficacy in slowing pancreatic and ovarian tumor progression in vitro and in vivo. Ivospemin shows modest induction of polyamine catabolism, but stronger repression of ornithine decarboxylase activity. Ivospemin is promising for research of cancers [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SBP-101. CAS No. 748119-79-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132822. | |
| IWP-2 | IWP-2 is an inhibitor of Wnt processing and secretion with an IC 50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC 50 of 40 nM for the gatekeeper mutant M82F CK1δ [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 686770-61-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13912. | |
| IWP-4 | IWP-4 is a small molecule Wnt inhibitor with an IC 50 of 25 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 686772-17-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12879. | |
| IWP L6 | IWP L6 (Porcn Inhibitor III) is a Porcn inhibitor with an EC 50 of 0.5 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Porcn Inhibitor III. CAS No. 1427782-89-5. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-15825. | |
| IWR-1 | IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway. Uses: Scientific research. Group: Signaling pathways. Alternative Names: endo-IWR 1; IWR-1-endo. CAS No. 1127442-82-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12238. | |
| Ixabepilone | Ixabepilone (BMS-247550) is an orally bioavailable microtubule inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-247550; Aza-epothilone B. CAS No. 219989-84-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-10222. | |
| Ixazomib | Ixazomib (MLN2238) is a selective, potent, and reversible proteasome inhibitor, which inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC 50 of 3.4 nM ( K i of 0.93 nM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: MLN2238. CAS No. 1072833-77-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10453. | |
| Ixazomib citrate | Ixazomib citrate (MLN9708) is a selective, orally active, second-generation proteasome inhibitor. Ixazomib citrate can be used for the study of a broad range of human malignancies [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MLN9708. CAS No. 1239908-20-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10452. | |
| Ixekizumab | Ixekizumab (LY2439821) is a humanized IgG4 monoclonal antibody that selectively binds and neutralizes interleukin IL-17A ( K D <3 pM). Ixekizumab directly blocks IL-17A binding to IL-17RA (IL-17A receptor) but does not bind to other IL-17 family members. Ixekizumab is used for the research of moderate-to-severe plaque psoriasis [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: LY2439821. CAS No. 1143503-69-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9924. | |
| I-XW-053 | I-XW-053 is an inhibitor of HIV-1 capsid protein that can suppress the replication of HIV-189BZ167 with an IC 50 value of 164.2 μM. I-XW-053 exhibits antiviral activity and can block the interface between capsid protein (CA) N-terminal domains (NTD-NTD interface) with micromolar affinity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 5496-35-5. Pack Sizes: 10 mM * 1 mL; 250 mg; 1 g; 5 g. Product ID: HY-103078. | |
| (±)-J-113397 | (±)-J-113397 is a potent and selective non-peptidyl ORL1 receptor antagonist with a K i of 1.8 nM for cloned human ORL1. J-113397 inhibited nociceptin/orphanin FQ-stimulated GTPγS binding to CHO cells expressing ORL1 with an IC 50 value of 5.3 nM. J-113397 can be used for researching the physiological roles of nociceptin/orphanin FQ [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 217461-40-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-107721. | |
| J-113397 | J-113397 is the first potent and selective nonpeptidyl ORL1 receptor antagonist ( K i : cloned human ORL1=1.8 nM) without any agonistic effects on other opioid receptors [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 256640-45-6. Pack Sizes: 5 mg. Product ID: HY-114072. | |
| J14 | J14 is a reversible sulfiredoxin inhibitor with an IC 50 of 8.1 μM. J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin , leading to cytotoxicity and cancer cell death [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1043854-13-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135008. | |
| J147 | J147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. J147 can pass the blood brain barrier (BBB). J147 can inhibit monoamine oxidase B ( MAO B ) and the dopamine transporter. J147 plays an impotant role in Alzheimers disease (AD) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1807913-16-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-13779A. | |
| J-2156 TFA | J-2156 TFA is a high potent, selective somatostatin receptor type 4 (SST 4 receptor) agonist with IC 50 s of 0.05 nM and 0.07 nM for human and rat SST 4 receptors, respectively. J-2156 TFA has anti-inflammatory activity and it is used for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws in rats [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 2387505-73-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111615A. | |
| JA2 | JA2 is an inhibitor of metalloendopeptidase 24.15 that can potentiate the hypotensive response to bradykinin in rat [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 277333-45-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-164704. | |
| JAB-2485 | JAB-2485 is a potent and selective Aurora kinase A (AURKA) inhibitor, with an IC 50 of 0.33 nM. JAB-2485 exhibits around 1700-fold selectivity for AURKA over AURKB. JAB-2485 induces cell cycle arrest and apoptosis. JAB-2485 can be used for the research of cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2899209-55-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-157396. | |
| JAB-3068 | JAB-3068 (SHP2-IN-6) is a potent SHP2 inhibitor, extracted from patent WO2017211303A1, compound 7, has an IC 50 of 25.8 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SHP2-IN-6. CAS No. 2169223-48-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131132. | |
| JAB-3068 hydrochloride | JAB-3068 (SHP2-IN-6) hydrochloride is a potent SHP2 inhibitor with an IC 50 of 25.8 nM. JAB-3068 hydrochloride is extracted from patent WO2017211303A1, compound 7 [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SHP2-IN-6 hydrochloride. CAS No. 2169223-49-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131132A. | |
| JAB-3312 | JAB-3312 is an orally effective anticancer phosphatase SHP2 inhibitor ( IC 50 : 1.9 nM) with anti-cancer activity. JAB-3312 has good tolerability and significantly induced tumor regression in a KYSE-520 mouse xenograft model [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2245082-05-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161952. | |
| JAK2-IN-7 | JAK2-IN-7 is a selective JAK2 inhibitor with IC 50 s of 3, 11.7, and 41 nM for JAK2, SET-2, and Ba/F3 V617F cells, respectively. JAK2-IN-7 possesses >14-fold selectivity over JAK1, JAK3, FLT3. JAK2-IN-7 stimulates cell cycle arrest in the G0/G1 phase and induces tumor cell apoptosis. Antitumor activities [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2593402-36-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131906. | |
| JAMM protein inhibitor 2 | JAMM protein inhibitor 2 (compound 180) is a potent JAMM protease inhibitor with IC 50 s of 10 μM, 46 μM and 89 μM for thrombin, Rpn11 and MMP2, respectively. JAMM protein inhibitor 2 can be used for researching anticancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 848249-35-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-147031. | |
| Janelia Fluor® 525, SE | Janelia Fluor 525, SE (JF525, SE) is a yellow fluorescent dye (Ex = 525 nm; Em = 549 nm) [1]. Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: JF525, SE; JF525, NHS. CAS No. 2975167-21-4. Pack Sizes: 2 mg. Product ID: HY-131020. | |
| Janelia Fluor® 549 TFA | Janelia Fluor® 549 TFA (JF549 TFA) is a fluorescent dye with the absorption maximum (λab (max)) of 549 nm and emission maximum (λem (max)) of 571 nm [1]. Janelia Fluor® products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: JF549 TFA. CAS No. 2245946-45-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-131022. | |
| Janelia Fluor® 646, SE | Janelia Fluor 646, SE (JF646, SE) is a red fluorescent dye can be used in cellular imaging [1]. Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: JF646, SE; JF646, NHS. CAS No. 1811539-59-9. Pack Sizes: 1 mg; 2 mg; 5 mg; 10 mg. Product ID: HY-130735. | |
| Janelia Fluor® 646, Tetrazine | Janelia Fluor 646, Tetrazine (JF646, Tetrazine) a red fluorescent dye that contains a tetrazine group. JF646, Tetrazine can be used in cellular imaging [1]. Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute. Janelia Fluor 646, Tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: JF646, Tetrazine. CAS No. 2042192-00-5. Pack Sizes: 200 μg; 500 μg; 1 mg. Product ID: HY-138659. | |
| Janelia Fluor® 669, SE | Janelia Fluor 669, SE (JF669, SE), a red fluorescent dye, can be directly reacted with the available thiol-containing HaloTag ligand under mild conditions (DIEA, DMF) to afford a JF669HaloTag ligand in a single step (Ex = 669 nm; Em = 682 nm) [1]. Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: JF669, SE; JF669, NHS. CAS No. 2127150-20-1. Pack Sizes: 2 mg. Product ID: HY-131030. | |
| Janus green B | Janus green B is a supravital stain. Janus green B staining reaction is oxygen dependent, and is reversibly inhibited by cyanide. Janus green B has been used for staining peripheral nerves in live insects, lymphatic vessels of rabbits and mitochondria [1] [2] [3]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 2869-83-2. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-D1122. | |
| (±)-Jasmonic acid | (±)-Jasmonic acid is an endogenous growth regulator closely related to plant resistance to abiotic stresses, used to activate defense responses to wounding, herbivory, and pathogen attacks. (±)-Jasmonic acid does not play an independent regulatory role, but works in a complex signaling network with other plant hormone signaling pathways. In addition, (±)-Jasmonic acid can also reduce chlorophyll levels in green and etiolated barley leaf segments and inhibit the elongation of rice seedlings [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 77026-92-7. Pack Sizes: 25 mg (2.38 M * 50 μL in Ethanol); 50 mg (2.38 M * 100 μL in Ethanol); 100 mg (2.38 M * 200 μL in Ethanol); 250 mg (2.38 M * 500 μL in Ethanol). Product ID: HY-122464. | |
| Jasmonic acid | Jasmonic acid ((-)-Jasmonic acid) is a plant growth regulator and a derivative of α-Linolenic acid (HY-N0728). Jasmonic acid signaling can also induce the MAP kinase cascade pathway, calcium channel, and many processes that interact with signaling molecules [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (-)-Jasmonic acid. CAS No. 6894-38-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-122464A. | |
| Jatrorrhizine chloride | Jatrorrhizine chloride is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities [1]. Jatrorrhizine chloride is a potent and orally active inhibitor of AChE ( IC 50=872 nM) over >115-fold selectivity for BuChE [2]. Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters [3]. Uses: Scientific research. Group: Natural products. CAS No. 6681-15-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 20 mg; 50 mg. Product ID: HY-N0740. | |
| Jatrorrhizine hydroxide | Jatrorrhizine?hydroxide is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities [1]. Jatrorrhizine hydroxide is a potent and orally active inhibitor of AChE ( IC 50=872 nM) over >115-fold selectivity for BuChE [2]. Jatrorrhizine hydroxide reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters [3]. Uses: Scientific research. Group: Natural products. CAS No. 483-43-2. Pack Sizes: 5 mg; 10 mg; 20 mg; 50 mg. Product ID: HY-N0749A. | |
| JB-95 | JB-95, a β-hairpin macrocyclic peptide, exhibits potent antimicrobial activity against Escherichia coli. JB-95 can selectively disrupt the outer membrane but not the inner membrane of E. coli [1]. Uses: Scientific research. Group: Peptides. CAS No. 1873323-60-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5753. | |
| JC-1 | JC-1 (CBIC2) is an ideal fluorescent probe widely used to detect mitochondrial membrane potential. JC-1 accumulates in mitochondria in a potential dependent manner and can be used to detect the membrane potential of cells, tissues or purified mitochondria. In normal mitochondria, JC-1 aggregates in the mitochondrial matrix to form a polymer, which emits strong red fluorescence (Ex=488 nm, Em=595 nm); When the mitochondrial membrane potential is low, JC-1 cannot aggregate in the matrix of mitochondria and produce green fluorescence (ex=488 nm, em= 530 nm) [1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: CBIC2. CAS No. 3520-43-2. Pack Sizes: 2 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-15534. | |
| JDTic dihydrochloride | JDTic (dihydrochloride) is a potent antagonist of kappa-opioid receptors (KOR) , blocking the κ-agonist U50, 488-induced antinociception. Uses: Scientific research. Group: Signaling pathways. CAS No. 785835-79-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10487. | |
| Jervine | Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC 50 of 500-700 nM [1]. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties [2]. Uses: Scientific research. Group: Natural products. Alternative Names: 11-Ketocyclopamine. CAS No. 469-59-0. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0836. | |
| JG26 | JG26 is an ADAM17 inhibitor, with IC 50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM for ADAM8, ADAM17, ADAM10 and MMP-12, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1464910-32-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120852. | |
| JHU-083 | JHU-083, a proagent of 6-diazo-5-oxo-L-norleucine (DON; HY-108357), is an orally active and selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b + cells and experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1998725-11-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122218. | |
| JHU395 | JHU395 is an orally-bioavailable and a plasma stable lipophilic glutamine antagonists (GA) proagent. JHU395 delivers 6-diazo-5-oxo-L-norleucine (DON) to malignant peripheral nerve sheath tumor (MPNST) in vitro and in vivo, and has antitumor activity in MPNST [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2079938-92-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128775. | |
| JH-X-119-01 | JH-X-119-01 is a potent and selective interleukin-1 receptor-associated kinases 1 ( IRAK1 ) inhibitor. JH-X-119-01 ameliorates LPS-induced sepsis in mice [1]. JH-X-119-01 inhibits IRAK1 biochemically with an apparent IC 50 of 9 nM while exhibiting no inhibition of IRAK4 at concentrations up to 10 μM [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2227368-54-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103017A. | |
| JH-X-119-01 hydrochloride | JH-X-119-01 hydrochloride is a potent and selective interleukin-1 receptor-associated kinases 1 ( IRAK1 ) inhibitor. JH-X-119-01 hydrochloride ameliorates LPS-induced sepsis in mice [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2591344-30-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-103017. | |
| JIB-04 | JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC 50 s of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 199596-05-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13953. | |
| JJKK 048 | JJKK 048 is a highly selective and potent monoacylglycerol lipase (MAGL) inhibitor with IC 50 values of 214 pM, 275 pM and 363 pM for human, rat, and mouse MAGL. JJKK 048 displays low cross-reactivity with other endocannabinoid targets. JJKK 048 can be used in the research of diseases such as cancer, neurodegenerative diseases, and pain [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1515855-97-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108613. | |
| JMS-17-2 | JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC 50 of 0.32 nM. JMS-17-2 impairs metastatic seeding and colonization of breast cancer cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1380392-05-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-123918. | |
| JMV 449 acetate | JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC 50 of 0.15 nM for inhibition of 125 I-neurotensin binding to neonatal mouse brain and an EC 50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 141863-45-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1256C. | |
| JNJ-10198409 | JNJ-10198409 is a relatively selective, orally active, and ATP competitive PDGF-RTK (platelet-derived growth factor receptor tyrosine kinase) inhibitor ( IC 50 =2 nM). It is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent. JNJ-10198409 has good activity against PDGFR-β kinase ( IC 50 =4.2 nM) and PDGFR-α kinase ( IC 50 =45 nM) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 627518-40-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-W011266. | |
| JNJ-10397049 | JNJ-10397049 is a potent and selective orexin 2 receptor (OX 2 R) antagonist, with a pK i of 8.3. JNJ-10397049 is 600-fold selective for the OX 2 R over the OX 1 R [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 708275-58-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10896. | |
| JNJ16259685 | JNJ16259685 is a selective antagonist of mGlu1 receptor , and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC 50 of 19 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 409345-29-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100407. | |
| JNJ-17203212 | JNJ-17203212 is a selective, potent and competitive TRPV1 antagonist. JNJ-17203212 is developed for researching pain management, such as migraine [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 821768-06-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100129. | |
| JNJ-18038683 | JNJ-18038683 is a 5-Hydroxytryptamine Type 7 ( 5-HT 7 ) receptor antagonist, with pK i s of 8.19, 8.20 for rat and human 5-HT 7 in HEK293 cells, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 851376-05-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19889. | |
| JNJ-37822681 dihydrochloride | JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D 2 receptor antagonist with a moderate binding affinity for the dopamine D 2L receptor ( K i =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2108806-02-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111066A. | |
| JNJ-38877605 | JNJ-38877605 is an orally active ATP-competitive inhibitor of c-Met with an IC 50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases [1] [2]. JNJ-38877605 inhibits c-Met phosphorylation and regulates lipid accumulation. JNJ-38877605 can be used for tumor and metabolic disease reseach [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 943540-75-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50683. | |
| JNJ-40418677 | JNJ-40418677 is an orally active modulator of γ-secretase , can cross the blood-brain barrier. JNJ-40418677 inhibits Aβ42 and NS2B-NS3 protease , with IC 50 s of 200 nM and 3.9 μM, respectively. JNJ-40418677 displays good biological tolerance, can be use for Alzheimers disease research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1146594-87-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100604. | |
| JNJ-41443532 | JNJ-41443532 (CCR2 antagonist 5) is a selective, orally active hCCR2 inhibitor with good binding affinity ( IC 50 =37 nM) and potent functional antagonism ( chemotaxis IC 50 =30 nM). JNJ-41443532 displays a K i of 9.6 μM for mCCR2 binding. JNJ-41443532 can be used in the research of inflammatory disease [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CCR2 antagonist 5. CAS No. 1228650-83-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13499. | |
| JNJ-42041935 | JNJ-42041935 is a potent, competitive and selective inhibitor of prolyl hydroxylase PHD ; inhibits PHD1, PHD2, and PHD3 with pK i values of 7.91±0.04, 7.29 ±0.05, and 7.65±0.09, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1193383-09-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12832. | |
| JNJ-42165279 | JNJ-42165279 is an orally active FAAH inhibitor, with IC 50 values of 70 nM for hFAAH and 313 nM for rFAAH. JNJ-42165279 can be used in research related to the field of neuropathic pain [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1346528-50-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19636. | |
| JNJ-5207852 | JNJ-5207852 is a selective and potent histamine H 3 receptor (H 3 R) antagonist, with pK i s of 8.9, 9.24 for rat and human H 3 R, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 398473-34-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12190. | |
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