MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Ketoisophorone | Ketoisophorone (4-Oxoisophorone) is a key intermediate in the synthesis of carotenoids and flavouring agents. Ketoisophorone is an industrially important cyclic endione [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 4-Oxoisophorone. CAS No. 1125-21-9. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-107832. |  |
| Ketone monoester | Ketone monoester is an orally available ketone monoester that serves as a source of nutritional ketones. Ketone monoester increases plasma beta-hydroxybutyrate, acetoacetate, blood glucose, blood sodium, and blood creatinine levels in mouse models. Ketone monoester has the potential to improve athletic performance and endurance in animals. Ketone monoester partially prevents myasthenia in septic mice. Ketone monoester may also be used to study Parkinson's disease or diabetes [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1208313-97-6. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 500 mg. Product ID: HY-15344. | |
| Ketoprofen | Ketoprofen (RP-19583) is a non-steroidal anti-inflammatory agent. Ketoprofen can inhibits the activity of cyclooxygenase with IC 50 values of 2 nM ( COX-1 ) and 26 nM ( COX-2 ). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RP-19583. CAS No. 22071-15-4. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-B0227. | |
| Ketorolac | Ketorolac (RS37619) is a non-steroidal anti-inflammatory drug (NSAID), acting as a nonselective COX inhibitor, with IC 50 s of 20 nM for COX-1 and 120 nM for COX-2. Ketorolac tromethamine is used as 0.5% ophthalmic solution for the research of allergic conjunctivitis, cystoid macular edema, intraoperative miosis, and postoperative ocular inflammation and pain. Ketorolac tromethamine is also a DDX3 inhibitor that can be used for cancer research [1] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RS37619. CAS No. 74103-06-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-B0580. | |
| Ketorolac tromethamine salt | Ketorolac tromethamine salt (RS37619 tromethamine salt) is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC 50 s of 20 nM for COX-1 and 120 nM for COX-2. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ketorolac Tromethamine; Ketorolac tris salt; RS37619 tromethamine salt. CAS No. 74103-07-4. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-B0138. | |
| Ketotifen | Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: HC 20-511. CAS No. 34580-13-7. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B0157. | |
| Ketotifen fumarate | Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: HC 20511 fumarate. CAS No. 34580-14-8. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B0157A. | |
| KG5 | KG5 is an orally active dual PDGFRβ and B-Raf allosteric inhibitor. KG5 also inhibits Flt3 , KIT and c-Raf. KG5 has anticancer, antiangiogenic activities [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 877874-85-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15198. | |
| KH-3 | KH-3 is a potent RNA-binding protein Hu antigen R (HuR) inhibitor with an IC 50 value of 0.35 μM. KH-3 has anti-proliferative activity. KH-3 suppresses breast cancer cell invasion as well as delays the initiation of lung colonies by disrupting HuR-FOXQ1 mRNA interaction [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1215115-03-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134601. | |
| KH7 | KH7 is a soluble adenylyl cyclase (sAC) -specific inhibitor, with IC 50 s of 3-10 μM toward both recombinant purified human sAC t protein and heterologously expressed sACt in cellular assays [1]. KH7 is also a cAMP inhibitor [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 330676-02-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103194. | |
| Khellin | Khellin is a furochromone that can be isolated from Ammi visnuga L. Khellin is an EGFR inhibitor with an IC 50 of 0.15 μM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 82-02-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1394. | |
| KHS101 hydrochloride | KHS101 hydrochloride could selectively induce a neuronal differentiation phenotype and interacts with transforming acidic coiled-coil-containing protein 3 (TACC3). Uses: Scientific research. Group: Signaling pathways. CAS No. 1784282-12-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10996A. | |
| Ki16425 | Ki16425 (Debio 0719) is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with K i s of 0.34 μM and 0.93 μM, respectively. Ki16425 (Debio 0719) reduces the LPA -induced activation of p42/p44 MAPK [1] [2]. Ki16425 can also inhibit LPA -induced dephosphorylation of Yes-associated protein (YAP)/TAZ in HEK293A cells [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Debio 0719. CAS No. 355025-24-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13285. | |
| KI-7 | KI-7 is an A2B adenosine receptor positive allosteric modulator. KI-7 potentiates the cAMP accumulation induced by the non-selective A2B adenosine receptor agonist NECA (EC 50 =445.8 nM). KI-7 also potentiates the cAMP accumulation induced by the selective A2B adenosine receptor agonist BAY 60-6583 as well as by adenosine with EC 50 s of 2390 nM and 2550 nM, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1489263-00-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-131032. | |
| Ki8751 | Ki8751 is a potent VEGFR2 inhibitor with an IC 50 of 0.9 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 228559-41-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12038. | |
| Kifunensine | Kifunensine, a potent and selective inhibitor of class I α-mannosidases isolated from Actinomycete, prevents α-mannosidases I from trimming mannose residues on glycoproteins. Kifunensine inhibits ERAD [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: FR-900494. CAS No. 109944-15-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19332. | |
| Kinesore | Kinesore is an inhibitor of the KLC2-SKIP Interaction. Uses: Scientific research. Group: Signaling pathways. CAS No. 363571-83-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-112777. | |
| Kinetin | Kinetin (N6-furfuryladenine) belongs to the family of N6-substituted adenine derivatives known as cytokinins, which are plant hormones involved in cell division, differentiation and other physiological processes. Kinetin has anti-aging effects [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 6-Furfuryladenine; N6-Furfuryladenine. CAS No. 525-79-1. Pack Sizes: 10 mM * 1 mL; 5 g; 10 g. Product ID: HY-N0160. | |
| KIRA-7 | KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase ( IC 50 of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 has an anti-fibrotic effect [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1937235-76-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124646. | |
| Kira8 | Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC 50 of 5.9 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AMG-18. CAS No. 1630086-20-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-114368. | |
| Kisspeptin-10, human | Kisspeptin-10, human is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, human acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression [1]. Uses: Scientific research. Group: Peptides. CAS No. 374675-21-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0254. | |
| Kisspeptin 234 TFA | Kisspeptin 234 TFA, is a 10 amino acid peptide as well as a kisspeptin receptor (KISS1, GPR54) antagonist. Kisspeptin 234 TFA is an analog of Kisspeptin 10 [1]. Uses: Scientific research. Group: Peptides. CAS No. 1848962-29-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1196A. | |
| Kisspeptin-54(human) | Kisspeptin-54(human) (Metastin(human)) is an endogenous ligand for kisspeptin receptor (KISS1, GPR54). Kisspeptin-54(human) binds to rat and human GPR54 receptors with K i values of 1.81 nM and 1.45 nM, respectively. Kisspeptin-54(human) inhibits tumor metastasis and stimulates the secretion of gonadotropin (LH) and testosterone [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Peptides. Alternative Names: Metastin(human). CAS No. 374683-24-6. Pack Sizes: 100 μg; 500 μg; 1 mg. Product ID: HY-P1022. | |
| KKII5 | KKII5 is a potent Lipoxygenase ( LOX-1 ) inhibitor with an IC 50 of 19 μM. KKII5 inhibits lipid peroxidation [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 6381-55-1. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-W488004. | |
| KKL-40 | KKL-40 is a small molecule inhibitor that targets the trans-transcription process and is effective against methicillin-sensitive and -resistant Staphylococcus aureus (S. aureus) as well as other Gram-positive pathogens including vancomycin-resistant Enterococcus faecium, Bacillus subtilis, and Streptococcus pyogenes. KKL-40 synergizes with the human antimicrobial peptide LL-37 to inhibit S. aureus, but does not synergize with other antibiotics such as daptomycin, kanamycin, or erythromycin. Trans-transcription is an extreme form of recoding, and KKL-40 inhibits trans-transcription but is nontoxic to HeLa cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 865285-47-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-116863. | |
| KL1333 | KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1800405-30-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-128895. | |
| KL-50 | KL-50 is a selective toxin toward tumors that lack the DNA repair protein O 6 -methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O 6 -alkylguanine lesions. KL-50 activates DNA damage response pathways and cycle arrest in MGMT-cells, independent of mismatch repair (MMR). KL-50 is promising for research of brain tumors that lack the DNA repair protein MGMT [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1161826-19-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164496. | |
| KN-93 | KN-93 is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II ( CaMKII ) with a K i of 370 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 139298-40-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15465. | |
| KN-93 hydrochloride | KN-93 hydrochloride is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II ( CaMKII ) with a K i of 370 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1956426-56-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15465A. | |
| KN-93 phosphate | KN-93 phosphate is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II , with K i of 370 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1913269-12-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-15465B. | |
| KNT-127 | KNT-127 is a potent δ-opioid receptor agonist that crosses the blood-brain barrier (BBB). KNT-127 is highly selective to the δ receptor, with K i values of 0.16, 21.3 and 153 nM for δ, μ and κ receptors, respectively. KNT-127 increases the release of dopamine and L-glutamate in the striatum, nucleus accumbens, and prefrontal cortex. KNT-127 has analgesic, antidepressant and antianxiety activities [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1256921-89-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-120511. | |
| Kojibiose | Kojibiose, an orally active prebiotic disaccharide, can specifically inhibit the activity of α-glucosidase I. kojibiose is a proliferation factor for Bifidobacterium , lactic acid bacteria, and eubacteria. kojibiose is a low-calorie sweetener capable of increasing the absorption of iron. Kojibiose exhibits antitoxic activity. Kojibiose reduces hepatic expression of inflammatory markers in vivo [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2140-29-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113133. | |
| Kojic acid | Kojic acid is a substance produced by Aspergillus oryzae that is orally effective and can also be absorbed transdermally. Kojic acid exhibits various biological activities, including anti-aging, anti-nematode, antimicrobial, antioxidant, and anti-inflammatory effects. Kojic acid is a Tyrosinase inhibitor with an Mushroom Tyrosinase IC 50 of 182.7 μM. Kojic acid prevents melanin production by capturing copper ions that bind to the tyrosinase active site, thus inhibiting its activation. Kojic acid also suppresses the NF-κB and p21 signaling pathways in human keratinocytes. Kojic acid derivatives have anticancer activity [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Natural products. CAS No. 501-30-4. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W050154. | |
| Kojic acid dipalmitate | Kojic acid dipalmitate (Kojic dipalmitate) is a derivative of Kojic acid (HY-W050154), a fungal metabolite that can be produced by species of Aspergillus , Acetobacter and Penicillium. Kojic acid dipalmitate is a slow and reversible competitive inhibitor of tyrosinase. Kojic acid dipalmitate can be used for skin?lightening agent research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Kojic dipalmitate. CAS No. 79725-98-7. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-W099579. | |
| KOTX1 | KOTX1 is an orally active and selective ALDH1A3 inhibitor. KOTX1 improves glucose tolerance, insulin secretion and blood sugar levels in diabetic mouse models [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1788963-83-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164781. | |
| KP372-1 | KP372-1 is an Akt inhibitor that inhibits proliferation and induces apoptosis and anoikis. KP372-1 is also an NQO1 redox cycling agent that causes DNA damage (including DNA breakage) by generating ROS. KP372-1 can be used in cancer research (such as head and neck squamous cell carcinoma (HNSCC) and pancreatic cancer) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1374996-60-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15673. | |
| KPT-185 | KPT-185 is an orally bioavailable and selective inhibitor of CRM1 and displays potent antiproliferative properties at submicromolar concentrations ( IC 50 =100-500 nM), induces apoptosis, cell-cycle arrest, and myeloid differentiation in AML cell lines and patient blasts [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1333151-73-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15611. | |
| Kras4B G12D-IN-1 | Kras4B G12D-IN-1 is a Kras4B G12D inhibitor with anticancer effects. Kras4B G12D-IN-1 decreases Kras protein expression in mouse embryonic fibroblasts (MEF) expressing Kras4B G12D (WO2016179558A1, Comp 994566) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2042365-85-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153413. | |
| K-Ras G12C-IN-1 | K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C extracted from patent WO 2014152588 A1. Uses: Scientific research. Group: Signaling pathways. CAS No. 1629265-17-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18604. | |
| K-Ras G12C-IN-4 | K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRAS G12C [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2376328-55-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128771. | |
| K-Ras(G12C) inhibitor 12 | K-Ras(G12C) inhibitor 12 is a K-Ras(G12C) inhibitor. K-Ras(G12C) inhibitor 12 acts on H1792 cells with an EC50 of 0.32 μM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1469337-95-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18707. | |
| KRAS G12C inhibitor 14 | KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 17, has an IC 50 of 18 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2349393-95-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125872. | |
| K-Ras(G12C) inhibitor 6 | K-Ras(G12C) inhibitor 6 is an irreversible, allosteric inhibitor of the K-Ras(G12C) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2060530-16-5. Pack Sizes: 2 mg. Product ID: HY-107841. | |
| K-Ras(G12C) inhibitor 9 | K-Ras (G12C) inhibitor 9 is an allosteric inhibitor of the K-Ras (G12C) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1469337-91-4. Pack Sizes: 2 mg. Product ID: HY-12446. | |
| Kresoxim-methyl | Kresoxim-methyl (BAS 490 F), a Strobilurin-based fungicide, inhibits the respiration at the complex III (cytochrome bc1 complex). Kresoxim-methyl binds to complex III from yeast with an apparent K d of 0.07 μM proving a high affinity for this enzyme [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAS 490 F. CAS No. 143390-89-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-125776. | |
| KRpep-2d | KRpep-2d is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research [1]. Uses: Scientific research. Group: Peptides. CAS No. 2098181-84-9. Pack Sizes: 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P3277. | |
| KS100 | KS100 is a potent ALDH inhibitor with IC 50 s of 230, 1542, 193 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS100 shows antiproliferative and anticancer effects with low low toxic. KS100 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS10600 induces apoptosis and cell cycle arrest at the G2/M phase [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2408477-54-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146682. | |
| KS370G | KS370G is an orally active hypoglycemic and cardiovascular protective agent. KS370G improves left ventricular hypertrophy and function in pressure-overload mice heart. KS370G reduces renal obstructive nephropathy [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 105955-01-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-114683. | |
| KSPWFTTL | KSPWFTTL is an immunodominant Kb-restricted epitope from the p15E transmembrane protein. KSPWFTTL can restore susceptibility of a tumor line to anti-AKR/Gross MuLV cytotoxic T lymphocytes [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 153049-05-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P3333. | |
| KSQ-4279 | KSQ-4279 (USP1-IN-1) is a potent USP1 inhibitor and a selective PARP1 inhibitor. KSQ-4279 is promising for research of cancers [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: USP1-IN-1. CAS No. 2446480-97-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145471. | |
| KT109 | KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC 50 of 42 nM. KT109 has ~60-fold selectivity for DAGLβ over DAGL&alpha. KT109 shows inhibitory activity against PLA2G7 (IC 50 =1 μM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-arachidonoylglycerol (2-AG), arachidonic acid and eicosanoids in mouse peritoneal macrophages [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1402612-55-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18540. | |
| KT172 | KT172 is a DAGLβ inhibitor with an IC 50 value of 11 nM. KT172 can be used for the research of metabolic and inflammatory [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1402612-56-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-18541. | |
| KT-253 | KT-253 is a p53 stabilizer and a PROTAC degrader for MDM2 ( DC 50 =0.4 nM). KT-253 inhibits the proliferation of cancer cell RS4;11 with an IC 50 of 0.3 nM, arrests the cell cycle at G2/M phase, and induces apoptosis. KT-253 exhibits antitumor efficacy in mouse models [1]. (Pink: ligand for target protein MDM2 ligand 4 (HY-170452); Black: linker (HY-W001478); Blue: ligand for E3 ligase cereblon (HY-163927)). Uses: Scientific research. Group: Signaling pathways. CAS No. 2713618-08-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-170451. | |
| KT-333 | KT-333 is a molecular glues that degrades STAT3 protein. KT-333 mediates the selective degradation of STAT3 through the ubiquitin-proteasome system by binding to STAT3 protein and E3 ubiquitin ligase von Hippel-Lindau protein (VHL). KT-333 has strong selectivity for STAT3 protein degradation and good antitumor activity. KT-333 can be used in the study of hematologic malignancies such as large granular lymphocytic leukemia (LGL-L), peripheral T-cell lymphoma (PTCL), and cutaneous T-cell lymphoma (CTCL) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2502186-79-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-156730. | |
| KT-474 | KT-474 (KYM-001) is an orally active PROTAC IRAK4 degrader with antitumor activities [1]. KT-474 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KYM-001; PROTAC IRAK4 degrader-7. CAS No. 2432994-31-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-145483. | |
| KT5720 | KT5720 is a potent, cell-permeable, specific, reversible and ATP-competitive PKA inhibitor ( IC 50 =3.3 μM). KT5720 is effective in reversing MDR1-mediated multidrug resistance. KT5720 also reduces the excitability of dorsal root ganglion (DRG) neurons by attenuating Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity and reducing intracellular Ca2 + concentrations. KT5720 can be used in the study of haematological malignancies as well as HCN and DRG neuron-related diseases [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 108068-98-0. Pack Sizes: 50 μg; 100 μg. Product ID: HY-N6789. | |
| KT5823 | KT5823, a selective the cGMP-dependent protein kinase ( PKG ) inhibitor with an K i value of 0.23 μM, it also inhibits PKA and PKC with K i values of 10 μM and 4 μM, respectively. KT5823 is a Staurosporine -related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na + /I - symporter) NIS expression, and iodide uptake in thyroid cells. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 126643-37-6. Pack Sizes: 100 μg. Product ID: HY-N6791. | |
| KU-0060648 | KU-0060648 is a dual inhibitor of PI3K and DNA-PK with IC 50 s of 4 nM, 0.5 nM, 0.1 nM, 0.594 nM and 8.6 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ and DNA-PK, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 881375-00-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-13431. | |
| KU-0063794 | KU-0063794 is a potent and specific mTOR inhibitor, inhibiting both the mTORC1 and mTORC2 complexes with IC 50 s of 10 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 938440-64-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50710. | |
| Kurarinone | Kurarinone is an orally active flavonoid isolated from matrine that inhibits the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting cell differentiation of Th1 and Th17. Kurarinone has antitumor and anti-inflammatory activity [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 34981-26-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-N2279. | |
| KUS121 | KUS121, a valosin-containing protein (VCP, p97) modulator with significant neuroprotective effects, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1357164-52-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-138233. | |
| Kuwanon K | Kuwanon K is a natural product that can be isolated from Morus Lhou [1]. Uses: Scientific research. Group: Natural products. CAS No. 88524-66-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N11463. | |
| Kv2.1-IN-1 | Kv2.1-IN-1 (compound 80) is a potent inhibitor of Kv2.1, with the IC 50 value of 0.07 μM, selectivity >130 fold over other K + , Na + , and Ca 2+ ion channels [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2252448-93-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161104. | |
| KW-2478 | KW-2478 is an inhibitor of Hsp90α , with an IC 50 of 3.8 nM, and has antitumor activity against various human hematological tumor cells. Uses: Scientific research. Group: Signaling pathways. CAS No. 819812-04-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13468. | |
| KW-8232 | KW-8232, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 217813-15-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100304A. | |
| KW-8232 free base | KW-8232 free base, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 170365-25-0. Pack Sizes: 1 mg. Product ID: HY-100304. | |
| KY02111 | KY02111 is a canonical WNT signaling (β-catenin) inhibitor which promotes differentiation of hPSCs to cardiomyocytes. KY02111 can be used for the research of human cardiomyocyte regeneration [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1118807-13-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13815. | |
| Kynuramine dihydrochloride | Kynuramine, an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 36681-58-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-119395B. | |
| Kynurenic acid | Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8. Uses: Scientific research. Group: Natural products. Alternative Names: Quinurenic acid. CAS No. 492-27-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-100806. | |
| Kynurenic acid sodium | Kynurenic acid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8. Uses: Scientific research. Group: Natural products. CAS No. 2439-2-3. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-107512. | |
Would you like to list your products on USA Chemical Suppliers?
Our database is helping our users find suppliers everyday.