MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| JNJ-63576253 | JNJ-63576253 (TRC-253) is a potent and orally active full antagonist of androgen receptor (AR) , with IC 50 s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the research of castration-resistant prostate cancer (CRPC) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TRC-253. CAS No. 2110428-64-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115282A. |  |
| JNJ-64264681 | JNJ-64264681 is a potent, orally active, selective and irreversible covalent BTK inhibitor. JNJ-64264681 exhibits good pharmacokinetic characteristics and can be used for cancer and autoimmune diseases research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2101524-34-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153245. | |
| JNJ-7777120 | JNJ-7777120 is a potent and selective histamine H 4 receptor antagonist ( K i =4.5 nM). JNJ-7777120 effectively blocks histamine-induced migration of mouse tracheal mast cells from connective tissue to epithelial cells. JNJ-7777120 also significantly blocks neutrophil infiltration in a mouse Zymosan-induced peritonitis model. JNJ-7777120 has a good potential to study antipruritic and anti-inflammatory [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 459168-41-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13508. | |
| (-)-JNJ-A07 | (-)-JNJ-A07 is a potent and selective DENV inhibitor with an EC 50 value of 31 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2135640-92-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139602C. | |
| ?JOE | JOE is a fluorescent dye and can be used as a fluorescent label in DNA sequencing, PCR, and LCR amplifications. JOE possesses an absorbance of 525 nm and an emission of 550 nm [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 82855-40-1. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-D1090. | |
| Josamycin | Josamycin (EN-141) is an orally active macrolide antibiotic exhibiting antimicrobial activity against a wide spectrum of pathogens, such as bacteria. The dissociation constant K d from ribosome for Josamycin is 5.5 nM [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: EN-141. CAS No. 16846-24-5. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B1920. | |
| JP83 | JP83 is an irreversible fatty acyl amide hydrolase (FAAH) inhibitor with an IC 50 of 1.6 nM in competitive activity-based protein profiling (ABPP) experiments [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 887264-44-0. Pack Sizes: 1 mg. Product ID: HY-111199. | |
| JS11 | JS11 is an inhibitor for natriuretic polypeptide receptor 1 ( Npr1 ) with an IC 50 of 1.9 μM for hNpr1. JS11 ameliorates the pruritus in mouse models [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1394592-04-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153650. | |
| JS25 | JS25 is a selective and covalent inhibitor of BTK that inactivates BTK with an IC 50 value of 5.8 nM by chelating Tyr551. JS25 inhibits cancer cells proliferation, pronounces cell death, and promotes murine xenograft model of Burkitts lymphoma. JS25 effectively crosses the blood-brain barrier [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2411771-95-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-151808. | |
| JS6 | JS6 is a Bcl3 inhibitor, and inhibits Bcl3-NF-kB1 binding. JS6 inhibits tumor cell growth in vitro and in vivo [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 950244-33-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152177. | |
| JT001 sodium | JT001 (NLRP3-IN-19) sodium is a potent, specific and orally active inhibitor of NLRP3. JT001 sodium can inhibit NLRP3 inflammasome assembly, resulting in the inhibition of cytokine release and the prevention of pyroptosis. JT001 sodium can be used for the research of nonalcoholic steatohepatitis and liver fibrosis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NLRP3-IN-19 sodium. CAS No. 2238820-09-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156034A. | |
| JTC-801 | JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist, binding to ORL1 receptor with a K i value of 8.2?nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 244218-51-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13274. | |
| JTE-013 | JTE-013 is a potent and specific S1P 2 (Sphingosine-1-Phosphate 2; EDG-5) antagonist. JTE-013 inhibits the specific binding of radiolabeled S1P to human and rat S1P 2 with IC 50 s of 17 nM and 22 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 383150-41-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-100675. | |
| JTE-907 | JTE-907 is a highly selective, orally active CB2 receptor inverse agonist and exerts anti-inflammatory effects in vivo [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 282089-49-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-103325. | |
| JTV-519 hemifumarate | JTV-519 hemifumarate (K201 hemifumarate) is a Ca 2+ -dependent blocker of sarcoplasmic reticulum Ca 2+ -stimulated ATPase ( SERCA ) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: K201 hemifumarate. CAS No. 1435938-25-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15293B. | |
| Juglone | Juglone (5-hydroxy-1,4-naphthalenedione) is a yellow dye that can be extracted from Juglans regia. Juglone induces apoptosis through the mitochondrial pathway. Juglone has antibacterial and antitumor activity [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: 5-Hydroxy-1,4-naphthalenedione. CAS No. 481-39-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N6949. | |
| JZL195 | JZL195 is a selective and efficacious dual fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibitor with IC 50 s of 2 and 4 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1210004-12-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15250. | |
| K114 | K114, a fluorescent Congo Red analogue, binds tightly to amyloid fibrils with an EC 50 of 20-30 nM [1]. K114 is an efficient detector of semen-derived enhancer of virus infection (SEVI) [2]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 872201-12-2. Pack Sizes: 2 mg; 5 mg. Product ID: HY-103470. | |
| K145 hydrochloride | K145 hydrochloride is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC 50 of 4.3 μM and a K i of 6.4 μM. K145 hydrochloride is inactive against SphK1 and other protein kinases. K145 hydrochloride induces cell apoptosis and has potently antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1449240-68-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15779A. | |
| K-604 dihydrochloride | K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 ( ACAT-1 ) inhibitor with an IC 50 of 0.45±0.06 μM. Uses: Scientific research. Group: Signaling pathways. CAS No. 217094-32-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100400A. | |
| K-7174 | K-7174 is an orally active proteasome and GATA inhibitor. K-7174 is a cell adhesion inhibitor. K-7174 induces cell apoptosis. K-7174 shows antitumor activities, it can be used for the research of cancer [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 191089-59-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12743. | |
| K-7174 dihydrochloride | K-7174 dihydrochloride is an orally active proteasome and GATA inhibitor. K-7174 dihydrochloride is a cell adhesion inhibitor. K-7174 dihydrochloride induces cell apoptosis. K-7174 dihydrochloride shows antitumor activities, it can be used for the research of cancer [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 191089-60-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12743A. | |
| K777 | K777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC 50 of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi , and cathepsins B and L. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 inhibits SARS-CoV and EBOV pseudovirus entry with IC 50 values of 0.68 nM and 0.87 nM, respectively [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 233277-99-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119293. | |
| K-8012 | K-8012, a sulindac (HY-B0008) analog, is a potent antagonist of RXRa. The IC 50 value for K-8012 to inhibit 9-cis-RA-induced Gal4-RXRa-LBD trans-activation were about 9.2 μM. K-8012 exerts improved anticancer activity over sulindac in a RXRa-dependent manner. K-8012 exhibits activity in inhibiting the tRXRa-mediated PI3K/AKT signaling pathway. K-8012 induces apoptosis and inhibits AKT activation by preventing tRXRa from binding to p85a [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1346513-17-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-121435. | |
| Kadsurenone | Kadsurenone. Uses: Scientific research. Group: Natural products. CAS No. 95851-37-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N10663. | |
| Kaempferide | Kaempferide is an orally active flavonol isolated from Hippophae rhamnoides L. Kaempferide has anticancer, anti-inflammatory, antioxidant, antidiabetic, antiobesity, antihypertensive, and neuroprotective activities. Kaempferide induces apoptosis. Kaempferide promotes osteogenesis through antioxidants and can be used in osteoporosis research [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Natural products. Alternative Names: Kaempferol 4'-O-methyl ether. CAS No. 491-54-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15449. | |
| Kaempferitrin | Kaempferitrin is a natural flavonoid, possesses antinociceptive, anti-inflammatory, anti-diabetic, antitumoral and chemopreventive effects, and activates insulin signaling pathway. Uses: Scientific research. Group: Natural products. Alternative Names: Lespedin; Lespenephryl. CAS No. 482-38-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N0628. | |
| Kaempferol | Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Kempferol; Robigenin. CAS No. 520-18-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-14590. | |
| Kaempferol 7-O-neohesperidoside | Kaempferol 7-O-neohesperidoside is a avonoid glycoside that can be isolated from Litchi chinensis. Kaempferol 7-O-neohesperidoside exhibits significant cytotoxic activity against A549, LAC, Hep-G2, and HeLa cell lines with IC 50 s of 0.53, 7.93, 0.020, and 0.051 μM, respectively [1]. Uses: Scientific research. Group: Natural products. CAS No. 17353-03-6. Pack Sizes: 500 μg; 1 mg. Product ID: HY-N8954. | |
| Kaempferol (Standard) | Kaempferol (Standard) is the analytical standard of Kaempferol. This product is intended for research and analytical applications. Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Kempferol(Standard); Robigenin (Standard). CAS No. 520-18-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14590R. | |
| Kahweol | Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase ( AMPK ) activation. Kahweol induces apoptosis. Uses: Scientific research. Group: Natural products. CAS No. 6894-43-5. Pack Sizes: 5 mg; 10 mg; 20 mg. Product ID: HY-N6258. | |
| Kainic acid | Kainic acid is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid induces seizures [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 487-79-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N2309. | |
| Kakkanin | Kakkanin comes from the roots of O. henryi and can be used for the research of anti-inflammatory [1]. Uses: Scientific research. Group: Natural products. CAS No. 63770-91-2. Pack Sizes: 1 mg. Product ID: HY-N9375. | |
| KALA | KALA is an amphiphilic peptide that forms an α-helical structure at physiological pH. KALA modifies a plasmid DNA-encapsulating liposomal membrane and is used as a fusogenic peptide in order to achieve effective liver targeting and transfection of DNA via galactose receptors [1]. Uses: Scientific research. Group: Peptides. CAS No. 187987-64-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2530. | |
| Kallikrein 5-IN-2 | Kallikrein 5-IN-2 (compound 21) is a selective Kallikrein KLK5 inhibitor (pIC 50 =7.1). KLK5 inhibition may normalise epidermal shedding and reduce the associated inflammation and itching [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2361160-57-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-148949. | |
| Kallikrein, Porcine pancreas | Kallikrein, Porcine pancreas (kininogenase) is capable of forming the kallikrenase kalinin system (KKS) in plasma and tissues, producing bradykinin and kalin peptides, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: kininogenase; SK-827. CAS No. 9001-1-8. Pack Sizes: 100 mg; 250 mg. Product ID: HY-P2795. | |
| Kanamycin | Kanamycin (Kanamycin A) is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia , which can be used in studies of tuberculosis and pneumonia [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Kanamycin A. CAS No. 59-01-8. Pack Sizes: 100 mg; 200 mg. Product ID: HY-16566. | |
| Kanamycins sulfate | Kanamycins sulfate is a broad-spectrum antibiotic, can be used in certain severe staphylococcal or Gram-negative bacillary infections. Kanamycin sulfate has certain ototoxicity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 70560-51-9. Pack Sizes: 1 g; 5 g. Product ID: HY-W040128. | |
| Kanamycin sulfate | Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin sulfate shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia , which can be used in studies of tuberculosis and pneumonia [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Kanamycin A sulfate. CAS No. 25389-94-0. Pack Sizes: 10 mM * 1 mL; 200 mg; 1 g; 5 g. Product ID: HY-16566A. | |
| Kanosamine hydrochloride | Kanosamine hydrochloride is an antibiotic which inhibits the growth of plant-pathogenic oomycetes, certain fungi and a few bacterial species. Kanosamine inhibits Phytophthora medicaginis M2913 and Aphanomyces euteiches WI-98 with MIC s of 25 and 60 μg/mL, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 57649-10-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-112176. | |
| κ-Carrageenan | κ-Carrageenan is a natural polymer which predominantly available in red seaweeds. κ-Carrageenan is an effective agent carrier to deliver curcumin in cancer cells and to induce apoptosis. κ-carrageenan serves as a potential inflammatory agent that magnifies existing intestinal inflammation [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: K-Carrageenan Karra Type. CAS No. 11114-20-8. Pack Sizes: 10 g; 25 g. Product ID: HY-138962. | |
| Karanjin | Karanjin is an orally active furanoflavonoid which can be isolated from several Leguminosae. Karanjin exhibits evident anti-diabetic, anti-cancer, anti-inflammatory, antioxidant, anticolitis, anti-ulcer, anti-Alzheimer properties and multiple insect repellent/insecticidal, acaricide properties, suggesting the potential of Karanjin to be applied to relevant research [1]. Uses: Scientific research. Group: Natural products. CAS No. 521-88-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N2534. | |
| Kartogenin | Kartogenin (KGN) is an inducer of chondrogenic tissue formation ( EC 50 : 100 nM). Kartogenin induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KGN. CAS No. 4727-31-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16268. | |
| Kartogenin sodium | Kartogenin (KGN) sodium is an inducer of chondrogenic tissue formation ( EC 50 : 100 nM). Kartogenin sodium induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin sodium also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin sodium is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin sodium promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KGN sodium. CAS No. 1401168-39-5. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-16268A. | |
| Kasugamycin hydrochloride | Kasugamycin hydrochloride (Ksg hydrochloride) is an antibiotic which binds both the 30S and 70S ribosome but not isolated 50S subunits. Kasugamycin hydrochloride (Ksg hydrochloride) mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Ksg hydrochloride. CAS No. 19408-46-9. Pack Sizes: 25 mg; 50 mg. Product ID: HY-B1864A. | |
| Kasugamycin hydrochloride hydrate | Kasugamycin (Ksg) hydrochloride hydrate is an antibiotic that binds to 30s and 70s ribosomes but not to the 50s subunit, and has anti-infective activity. Kasugamycin hydrochloride hydrate mimics mRNA nucleotides, disrupts tRNA binding and inhibits canonical translation initiation. Kasugamycin hydrochloride hydrate increases the sensitivity of mycobacteria to Rifampicin (HY-B0272) in vitro and in mouse infection models [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ksg hydrochloride hydrate. CAS No. 200132-83-8. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-B1864B. | |
| Katacalcin | Katacalcin (PDN 21) is a potent plasma calcium-lowering peptide [1]. Uses: Scientific research. Group: Peptides. Alternative Names: PDN 21. CAS No. 85916-47-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P0149. | |
| Kaurenoic acid | Kaurenoic acid is a diterpene derived from Sphagneticola trilobata. Kaurenoic acid has antibacterial, anti-inflammatory, anticonvulsant, analgesic, and aortic vasodilating effects [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 6730-83-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 20 mg. Product ID: HY-N1469. | |
| Kavain | Kavain is a class of kavalactone isolated from Piper methysticum , which has anxiolytic properties in animals and humans. Kavain positively modulated γ-Aminobutyric acid type A (GABAA) receptor [1]. Uses: Scientific research. Group: Natural products. CAS No. 3155-48-4. Pack Sizes: 10 mM * 1 mL; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-N2096. | |
| (+)-Kavain | (+)-Kavain, a main kavalactone extracted from Piper methysticum , has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na + and Ca 2+ channels [1]. (+)-Kavain is shown to bind at the α4β2δ GABA A receptor and potentiate GABA efficacy [2]. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied [4]. Uses: Scientific research. Group: Natural products. CAS No. 500-64-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-B1671. | |
| KB-05 | KB-05 is an electrophilic fragment molecule that can be used in DIA-based quantitative chemical proteomic screening studies. Uses: Scientific research. Group: Signaling pathways. CAS No. 1956368-15-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-149461. | |
| KB-0742 | KB-0742 is a potent, selective and orally active CDK9 inhibitor with an IC 50 of 6 nM for CDK9/cyclin T1. KB-0742 is selective for CDK9/cyclin T1 with >50-fold selectivity over other CDK kinases. KB-0742 has potent anti-tumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2416873-83-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137478. | |
| KB-0742 dihydrochloride | KB-0742 dihydrochloride is a potent, selective and orally active CDK9 inhibitor with an IC 50 of 6 nM for CDK9/cyclin T1. KB-0742 dihydrochloride is selective for CDK9/cyclin T1 with >50-fold selectivity over other CDK kinases. KB-0742 dihydrochloride has potent anti-tumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2416874-75-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137478A. | |
| KC01 | KC01 is an effective inhibitor of ABHD16A , with IC 50 s of 90 nM for hABHD16A and 520 nM for mABHD16A. KC01 significantly reduces lyso-PSs, and decreases lyso-PS and LPS-induced cytokine production in mouse macrophages [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1646795-59-6. Pack Sizes: 1 mg. Product ID: HY-120299. | |
| Kdo2-Lipid A ammonium | Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxin activity equal to LPS. Kdo2-Lipid A ammonium is highly selective for TLR4. Kdo2-Lipid A ammonium stimulates the release of both TNF and PGE2 [1]. Uses: Scientific research. Group: Natural products. CAS No. 1246298-62-3. Pack Sizes: 1 mg. Product ID: HY-N8277. | |
| Kebuzone | Kebuzone is a non-steroidal anti-inflammatory substance that may be studied in inflammatory diseases such as thrombophlebitis and rheumatoid arthritis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ketazone; Ketophenylbutazone. CAS No. 853-34-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111284. | |
| Keliximab | Keliximab (SB-210396) is a chimeric human/macaque IgG1 anti-CD4 monoclonal antibody with a K i value of 1.0 nM for soluble CD4. Keliximab blocks T cell proliferation and inhibits IL-2 production. Keliximab can be used for cancer research [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: SB-210396; IDEC CE9.1. CAS No. 174722-30-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99680. | |
| Kemptide | Kemptide is a synthetic heptapeptide that acts as a specific substrate for cAMP-dependent protein kinase ( PKA ). Uses: Scientific research. Group: Peptides. CAS No. 65189-71-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0248. | |
| Kenpaullone | Kenpaullone is a potent inhibitor of CDK1/cyclin B and GSK-3β , with IC 50 s of 0.4 μM and 23 nM, and also inhibits CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25 with IC 50 s of 0.68 μM, 7.5 μM, 0.85 μM, respectively. Kenpaullone, a small molecule inhibitor of KLF4 , reduces self-renewal of breast cancer stem cells and cell motility in vitro. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 9-Bromopaullone; NSC-664704. CAS No. 142273-20-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12302. | |
| KER047 | ALK2-IN-4 is a potent ALK2 inhibitor extracted from patent WO2020086963A1, compound Formula I free base [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ALK2-IN-4. CAS No. 2248154-85-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136773. | |
| KER047 succinate | ALK2-IN-4 succinate is a potent ALK2 inhibitor extracted from patent WO2020086963A1, compound Formula I free base [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ALK2-IN-4 succinate. CAS No. 2416307-25-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136773A. | |
| Keracyanin chloride | Keracyanin chloride (Cyanidin 3-rutinoside chloride), an anthocyanin, has antioxidant activity. Keracyanin chloride inhibits malonaldehyde formation in oxidized calf thymus DNA [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Cyanidin 3-rutinoside chloride; Cyanidin 3-O-rutinoside chloride; Sambucin chloride. CAS No. 18719-76-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-105935. | |
| Keratinase | Keratinase (KerA) is a protease that are able to degrade keratins into amino acids [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KerA. CAS No. 37341-53-0. Pack Sizes: 500 U. Product ID: HY-E70193. | |
| Ketanserin | Ketanserin is a selective 5-HT2 receptor antagonist. Ketanserin also blocks hERG current ( I hERG ) in a concentration-dependent manner ( IC 50 =0.11 μM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: R41468. CAS No. 74050-98-9. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-10562. | |
| Ketanserinol | Ketanserinol (R 46742) is a metabolite of Ketanserin (HY-10562). Ketanserinol is a competitive antagonist of the effects of 5-HT (HY-B1473A) in both arteries. The K B values are 6.5 for large coronary arteries and 6.4 for pulmonary arteries [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R 46742. CAS No. 76330-73-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121208. | |
| Ketanserin tartrate | Ketanserin (R41468) tartrate is a selective 5-HT2 receptor antagonist. Ketanserin tartrate also blocks hERG current ( I hERG ) in a concentration-dependent manner ( IC 50 =0.11 μM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: R41468 tartrate. CAS No. 83846-83-7. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-10562A. | |
| Ketoconazole | Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ketoconazol; R 41400. CAS No. 65277-42-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 1 g; 5 g. Product ID: HY-B0105. | |
| (-)-Ketoconazole | (-)-Ketoconazole ((-)-R 41400) is one of the enantiomer of Ketoconazole. Ketoconazole is a racemic mixture of two enantiomers, levoketoconazole ((2S,4R)-(-)-ketoconazole) and dextroketoconazole ((2R,4S)-(+)-ketoconazole). Uses: Scientific research. Group: Signaling pathways. Alternative Names: (-)-Ketoconazol; (-)-R 41400. CAS No. 142128-57-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0105B. | |
| (+)-Ketoconazole | (+)-Ketoconazole ((+)-R 41400) is an imidazole anti-fungal agent, a CYP3A4 inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (+)-Ketoconazol; (+)-R 41400. CAS No. 142128-59-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0105A. | |
| Ketodarolutamide | Ketodarolutamide (ORM-15341) is a potent and full antagonist for human AR (hAR) with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an androgen-responsive luciferase reporter gene construct. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 1896953; ORM-15341. CAS No. 1297537-33-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19337. | |
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