MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Piperazine adipate | Piperazine adipate is a potent broad spectrum anthelmintic against many common worm infections in mammals. Uses: Scientific research. Group: Signaling pathways. CAS No. 142-88-1. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-B2186. |  |
| Piperazine citrate | Piperazine (1,4-Diazacyclohexane) citrate is a gamma-aminobutyric acid (GABA) agonist [1]. Piperazine citrate is a vital building block and is an essential core in numerous marketed agents with diverse pharmacological activities [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1,4-Diazacyclohexane citrate. CAS No. 144-29-6. Pack Sizes: 500 mg. Product ID: HY-17599. | |
| Piperidolate | Piperidolate is an antimuscarinic, inhibits intestinal cramp induced by acetylcholine (rats and dogs). Uses: Scientific research. Group: Signaling pathways. CAS No. 82-98-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-B0962A. | |
| Piperidolate hydrochloride | Piperidolate hydrochloride is an antimuscarinic, inhibits intestinal cramp induced by acetylcholine (rats and dogs). Uses: Scientific research. Group: Signaling pathways. CAS No. 129-77-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg. Product ID: HY-B0962. | |
| Piperine | Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC 50 of 61.94±0.054 μg/mL [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Bioperine; 1-Piperoylpiperidine. CAS No. 94-62-2. Pack Sizes: 10 mM * 1 mL; 5 g; 10 g. Product ID: HY-N0144. | |
| Piperitone | Piperitone is as a powerful repellent and antiappetent agent. Piperitone is very toxic to Cymbopogon schoenanthus ( C. schoenanthus ) adults, newly laid eggs and to neonate larvae. Insecticidal activity [1]. Uses: Scientific research. Group: Natural products. CAS No. 89-81-6. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-N9496. | |
| Piperlongumine | Piperlongumine is a alkaloid [1] , possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities [2]. Piperlongumine induces ROS, and induces apoptosis in cancer cell lines [1]. Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway. Piperlongumin could be used in the study of migrasome [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Piplartine. CAS No. 20069-09-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N2329. | |
| Piperlonguminine | Piperlonguminine is an alkaloid amide isolated from the Piper species. Piperlonguminine shows various biological properties, including anti-inflammatory, antitumor, neuroprotective, anti-platelet, anti-melanogenic, antifungal and antibacterial activities [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 5950-12-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-126562. | |
| Piperonyl alcohol | Piperonyl alcohol is a benzodioxole derivative. It is biocompatible and can be used in chemical synthesis as an initiator [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 495-76-1. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g; 10 g. Product ID: HY-W028108. | |
| Piperonyl butoxide | Piperonyl butoxide (ENT-14250) is a pesticide synergist and food additive. Piperonyl butoxide has adverse effects on reproduction, development and behavior in mice. Piperonyl butoxide can activate c-Jun and ATF-2 in mouse hepatocytes. Piperonyl butoxide is a liver cancer carcinogen in rats and mice [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ENT-14250. CAS No. 51-03-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B1198. | |
| Piperoxan hydrochloride | Piperoxan (Benodaine) hydrochloride is an α 2 adrenoceptor antagonist. Piperoxan hydrochloride is the first-generation antihistamine. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Benodaine hydrochloride. CAS No. 135-87-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100850. | |
| PIPES | PIPES (1,4-Piperazinediethanesulfonic acid) is an important component of PIPES buffer agent used in biochemistry [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 1,4-Piperazinediethanesulfonic acid. CAS No. 5625-37-6. Pack Sizes: 5 g. Product ID: HY-D0875. | |
| PIPES disodium | PIPES (1,4-Piperazinediethanesulfonic acid) disodium is an important component of PIPES buffer agent used in biochemistry [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 1,4-Piperazinediethanesulfonic acid disodium. CAS No. 76836-02-7. Pack Sizes: 500 g. Product ID: HY-W040147. | |
| Pipobroman | Pipobroman is a bromide derivative of piperazine and acts as an alkylating agent. Pipobroman plays its role by inhibiting DNA and RNA polymerase or by reducing pyrimidine nucleotide incorporation into DNA. Pipobroman can be used for the cancer research, including polycythemia vera, myeloproliferative neoplasm, and AML et.al [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 54-91-1. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-16398. | |
| Piracetam | Piracetam (UCB-6215) is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders. Uses: Scientific research. Group: Signaling pathways. Alternative Names: UCB-6215. CAS No. 7491-74-9. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B0585. | |
| Pirarubicin | Pirarubicin is an anthracycline antibiotics, acts as a topoisomerase II inhibitor, and is a widely used for treatment of various cancers, in particular, solid tumors. Uses: Scientific research. Group: Signaling pathways. Alternative Names: THP. CAS No. 72496-41-4. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13725. | |
| Pirarubicin Hydrochloride | Pirarubicin Hydrochloride is an anthracycline antibiotics, acts as a topoisomerase II inhibitor, and is a widely used for treatment of various cancers, in particular, solid tumors. Uses: Scientific research. Group: Signaling pathways. Alternative Names: THP Hydrochloride. CAS No. 95343-20-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13725A. | |
| Pirenoxine | Pirenoxine (Catalin K) is a potent antioxidant. Pirenoxine shows anti-presbyopic activity. Pirenoxine has the potential for the research of cataracts [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Catalin K. CAS No. 1043-21-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-108296. | |
| Pirenperone | Pirenperone (R 47465) is a 5-HT 2 serotonin receptor antagonist. Pirenperone exhibits modest anxiolytic activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R 47465. CAS No. 75444-65-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B1737. | |
| Pirenzepine | Pirenzepine (LS 519 free base) is a selective M1 mAChR ( muscarinic acetylcholine receptor ) antagonist. Pirenzepine reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine shows anti-proliferative activity to cancer cells [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LS 519 free base; Pirenzepin; Gastrozepin. CAS No. 28797-61-7. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 500 mg. Product ID: HY-17037A. | |
| Pirenzepine dihydrochloride | Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR ( muscarinic acetylcholine receptor ) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LS 519; Pirenzepin dihydrochloride; Gastrozepin dihydrochloride. CAS No. 29868-97-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-17037. | |
| Pirepemat fumarate | Pirepemat (IRL752) fumarate is a corticalpreferring catecholamine- and cognition-promoting agent. Pirepemat fumarate is used for the study of Parkinson's disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IRL752 fumarate. CAS No. 2251806-70-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137447A. | |
| Piretanide | Piretanide is an oral active, relatively safe and effective diuretic. Piretanide has the potential for the research of congestive heart failure with a potential advantage of having potassium-sparing properties. Piretanide can also be used for the research of hypertension [1] > [2] >. Uses: Scientific research. Group: Signaling pathways. CAS No. 55837-27-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119816. | |
| Pirfenidone | Pirfenidone (AMR69) is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AMR69. CAS No. 53179-13-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-B0673. | |
| Pirfenidone (Standard) | Pirfenidone (Standard) is the analytical standard of Pirfenidone. This product is intended for research and analytical applications. Pirfenidone (AMR69) is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 53179-13-8. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0673R. | |
| Piribedil | Piribedil is a potent and orally active dopamine D2 and dopamine D3 agonist. Piribedil is also a α2-adrenoceptors antagonist. Piribedil can inhibit MLL1 methyltransferase activity ( EC 50 : 0.18 μM). Piribedil has the potential for the research of parkinson's disease, circulatory disorders, cancers [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3605-1-4. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-12707. | |
| Pirimicarb | Pirimicarb is a fast-acting selective carbamate insecticide on a wide range of crops including cereals, sugar beet, potatoes, fruits and vegetables. Pirimicarb is an AChE inhibitor and an acaricide [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 23103-98-2. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-119419. | |
| Pirimiphos-methyl | Pirimiphos-methyl is a rapid-acting organophosphorus insecticide and acaricide, causing inhibition of AChE in target organisms. Pirimiphos-methyl is often used for prevention and control of beetles, snout beetles, moths and Ephestia cautella during storage of agricultural grains [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 29232-93-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg. Product ID: HY-B1881. | |
| Pirinixic acid | Pirinixic acid (Wy-14643) is a potent agonist of PPARα , with EC 50 s of 0.63 μM, 32 μM for murine PPARα and PPARγ, and 5.0 μM, 60 μM, 35 μM for human PPARα , PPARγ and PPARδ, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Wy-14643. CAS No. 50892-23-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-16995. | |
| Pirlindole | Pirlindole is a selective and reversible MAO-A inhibitor [1]. Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3) [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 60762-57-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-100679. | |
| Piroctone olamine | Piroctone olamine is a pyridine derivate. It is known to have a fungicidal effect. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Piroctone ethanolamine. CAS No. 68890-66-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B1345. | |
| Piromelatine | Piromelatine (Neu-P11) is a melatonin MT 1 /MT 2 receptor agonist, serotonin 5-HT 1A / 5-HT 1D agonist, and serotonin 5-HT 2B antagonist. Piromelatine (Neu-P11) possesses sleep promoting, analgesic, anti-neurodegenerative, anxiolytic and antidepressant potentials. Piromelatine (Neu-P11) also possesses pain-related P2X3, TRPV1, and Nav1.7 channel-inhibition capacities [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Neu-P11. CAS No. 946846-83-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105285. | |
| Piroxicam | Piroxicam (CP-16171) is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC 50 s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CP-16171. CAS No. 36322-90-4. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B0253. | |
| Pirtobrutinib | Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations. Pirtobrutinib causes regression of BTK-dependent lymphoma tumors in mouse xenograft models. Pirtobrutinib is also more than 300-fold selective for BTK versus 370 other kinases tested and shows no significant inhibition of non-kinase off-targets at 1 μM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LOXO-305. CAS No. 2101700-15-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131328. | |
| PIT | PIT (2,2'-Pyridylisatogen tosylate) is a selective and non-competitive antagonist of P2Y1 receptor with an IC 50 value of 0.14 μM for human P2Y1 receptor. PIT antagonizes P2Y1 receptor signaling without affecting nucleotide binding. PIT is an irreversible antagonist of responses to ATP at metabotropic purinoceptors (of the P2Y family) in some smooth muscles. PIT can be used for the research of chronic bronchitis and asthma [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2,2'-Pyridylisatogen tosylate. CAS No. 56583-49-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108662. | |
| PIT-1 | PIT-1 is a selective PIP3 (phosphatidylinositol 3,4,5-trisphosphate) antagonist. PIT-1 inhibits cancer cell survival and induces apoptosis by inhibition of PIP3 dependent PI3K / Akt signaling. PIT-1 exhibits antitumor activity in vivo [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 53501-41-0. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103224. | |
| Pitavastatin | Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC 50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects [1] [2] [3] [8]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NK-104. CAS No. 147511-69-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-B0144A. | |
| Pitavastatin Calcium | Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC 50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin Calcium also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects [1] [2] [3] [8]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NK-104 hemicalcium; Pitavastatin hemicalcium. CAS No. 147526-32-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0144. | |
| Pitavastatin lactone | Pitavastatin lactone is a major metabolite of Pitavastatin in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase little metabolized in hepatic microsomes [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 141750-63-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-125643. | |
| PITCOIN4 | PITCOIN4 is a highly selective Class II Alpha PI3K-C2? inhibitor. PITCOIN4 shows nanomolar inhibition of PI3K-C2? and >100-fold selectivity in a general kinase panel[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156406. | |
| Pitofenone hydrochloride | Pitofenone hydrochloride, a spasmolytic compound, inhibits the acetylcholinesterase ( AChE ) activity from bovine erythrocytes and from electric eel with K i s of 36 and 45 μM, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1248-42-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110389. | |
| Pitolisant | Pitolisant is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor ( K i =0.16 nM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: Tiprolisant. CAS No. 362665-56-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12199. | |
| Pitolisant hydrochloride | Pitolisant hydrochloride is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor ( K i =0.16 nM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ciproxidine; BF 2649. CAS No. 903576-44-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12199B. | |
| Pitstop 2 | Pitstop 2 is a clathrin inhibitor which inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. Pitstop 2 has the potential for anti-cancer research[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1419320-73-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115604. | |
| Pivagabine | Pivagabine (CXB 722) is a hydrophobic 4-aminobutyric acid derivative with neuromodulatory activity. Pivagabine penetrates the blood-brain barrier in rats. Pivagabine antagonizes the effects of foot shock on both GABAA receptor function and corticotropin-releasing factor (CRF) concentrations in rat brain [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CXB-722. CAS No. 69542-93-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-108295. | |
| Pivekimab | Pivekimab is a human IgG1 monoclonal antibody that targets interleukin-3 (IL-3) and CD123. Pivekimab is used to synthesize pivekimab sunirine, a CD123-directed antibody-active molecule conjugate ( ADC ). Pivekimab is used in the study of blastic plasmacytoid dendritic cell neoplasm (BPDCN) [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2234335-84-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99234. | |
| Pivmecillinam hydrochloride | Pivmecillinam hydrochloride (FL-1039 hydrochloride) is an orally active proagent of mecillinam, an extended-spectrum penicillin antibiotic. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FL-1039 hydrochloride. CAS No. 32887-03-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0810A. | |
| Pivmecillinam (hydrochloride) (Standard) | Pivmecillinam (hydrochloride) (Standard) is the analytical standard of Pivmecillinam (hydrochloride). This product is intended for research and analytical applications. Pivmecillinam hydrochloride (FL-1039 hydrochloride) is an orally active proagent of mecillinam, an extended-spectrum penicillin antibiotic. Uses: Scientific research. Group: Signaling pathways. CAS No. 32887-03-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0810AR. | |
| Pixantrone | Pixantrone (BBR 2778) dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BBR 2778. CAS No. 144675-97-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13727A. | |
| Pizotifen | Pizotifen (Pizotyline) is a potent 5-HT 2 receptor antagonist, with a high affinity for 5-HT 1C binding site. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Pizotyline; BC-105. CAS No. 15574-96-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-B0115. | |
| Pizotifen malate | Pizotifen malate (Pizotyline malate) is a potent 5-HT 2 receptor antagonist, with a high affinity for 5-HT 1C binding site. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Pizotyline malate; BC-105 malate. CAS No. 5189-11-7. Pack Sizes: 100 mg. Product ID: HY-B0115A. | |
| PJ34 | PJ34 is a potent specific inhibitor of PARPl/2 with IC50 of 110 nM and 86 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 344458-19-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13688A. | |
| pJAK2(1001-1013) | pJAK2(1001-1013) is a SOCS1/3 antagonist. pJAK2(1001-1013) plays a positive role in antiviral immune response by inhibiting the negative regulatory effect of SOCS proteins and enhancing the JAK/STAT signaling pathway[1]. Uses: Scientific research. Group: Peptides. CAS No. 1259928-08-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P10373. | |
| PK11007 | PK11007 is a mild thiol alkylator with anticancer activity. PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. PK11007 induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 874146-69-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128784. | |
| PK 11195 | PK 11195 (RP 52028) is a ligand of translocator protein (TSPO) , which targets Leishmania chemotherapy, with IC 50 s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis , L. major and L. braziliensis , respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RP 52028. CAS No. 85532-75-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19567. | |
| PK150 | PK150, an analogue of Sorafenib, shows oral bioavailability and antibacterial activity against several pathogenic strains at submicromolar concentrations. PK150 inhibits Gram-positive Methicillin-sensitive S. aureus (MSSA), Methicillin-resistant S. aureus (MRSA), Vancomycin intermediate S. aureus (VISA) with MICs of 0.3, 0.3-1, 0.3 ?M, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2165324-62-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133119. | |
| PK68 | PK68 is a potent orally active and specifical type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of ~90?nM, displays inhibition of RIPK1-dependent necroptosis. PK68 powerfully ameliorates TNF-induced systemic inflammatory response syndrome, and can be used for the research of inflammatory disorders and cancer metastasis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2173556-69-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128348. | |
| PKCβ inhibitor 1 | PKC? inhibitor 1 is a potent, ATP-competitive, and selective PKC? inhibitor with IC50s of 21 and 5 nM for human PKC?1 and PKC?2, respectively. PKC? inhibitor 1 exhibits selectivity of more than 60-fold in favor of PKC?2 relative to other PKC isozymes (PKC?, PKC?, and PKC?)[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 257879-35-9. Pack Sizes: 10 mM * 1 mL; 500 ?g; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-13335. | |
| PKC/PKD-IN-1 | PKC/PKD-IN-1 (Compound 13C) is an orally active dual protein kinase C/D ( PKC/PKD ) inhibitor with an IC 50 value of 0.6 nM for PKD1. PKC/PKD-IN-1 can attenuate high-salt diet-induced cardiac hypertrophy and can be used in the study of heart failure [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1071135-06-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-128142. | |
| PKCTheta-IN-2 | PKCTheta-IN-2 (compound 14) is a potent and selective PKCθ inhibitor with an IC 50 of 0.25 nM. PKCTheta-IN-2 shows good selectivity over a wide range of kinases, including the PKC subfamily (30 kinases). PKCTheta-IN-2 inhibits the IL-2 production in a mouse ( IC 50 of 682 nM) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1810742-60-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-164756. | |
| PKCζ-IN-1 | PKCζ-IN-1 is a compound that inhibits PKCζ and CDK2, showing an IC50 value of 5.18 nM for PKCζ and 1.04 μM for CDK2, with significant selectivity of 200-fold. PKCζ-IN-1 can reduce the activity of CDK2 while inhibiting PKC&zeta. Uses: Scientific research. Group: Signaling pathways. CAS No. 1132609-87-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-120497. | |
| PKD-IN-1 dihydrochloride | PKD-IN-1 dihydrochloride (compound 32), an aminoethylamino-aryl (AEAA) compound, acts as PKD-1 inhibitor. PKD-IN-1 can be used for protein kinase D (PKD)-mediated diseases research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2308510-39-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131962A. | |
| PKG Substrate | PKG Substrate is a selective substrate for cGMP-dependent protein kinase ( PKG ). Uses: Scientific research. Group: Peptides. CAS No. 81187-14-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1561. | |
| PKH 26 | PKH 26 is a red fluorescent dye, PKH 26 can stably bind to the lipid region of cell membrane and emit red fluorescence (Ex/Em=551/567 nm), which is mainly used for in vitro cell labeling, in vitro cell proliferation studies and in vivo and in vitro cell tracing studies[1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 154214-55-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-D1451. | |
| PKH 67 | PKH67 is a fluorescent cell binding dye with green fluorescence. PKH67 can stain the cell membrane and the Ex/Em is 490/502 nm. PKH67 is often used in combination with the non-specific red fluorescent dye PKH26 (Ex/Em=551/567 nm) to label cells, detect cell proliferation in vitro, and trace cells in vitro and in vivo[1][2]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 257277-27-3. Pack Sizes: 100 ?L; 1 mL. Product ID: HY-D1421. | |
| PKI 14-22 amide,myristoylated | PKI 14-22 amide, myristoylated is a selective, cAMP-dependent, competitive PKA inhibitor with Ki=~36 nM. The myristoylation modification of PKI 14-22 amide, myristoylated makes it more permeable to cell membranes and blood-brain barriers than the precursor molecule. PKI 14-22 amide, myristoylated can block the phosphorylation of cAMP-dependent downstream targets (such as CREB). PKI 14-22 amide, myristoylated can prevent the development of morphine analgesic tolerance in mice, and also inhibits protein translation and negative-strand RNA synthesis of Zika virus. PKI 14-22 amide, myristoylated can be used in research fields such as opioid tolerance mechanisms and antiviral drugs[1][2][3]. Uses: Scientific research. Group: Peptides. CAS No. 201422-03-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P1291. | |
| PKM2-IN-1 | PKM2-IN-1 (compound 3k) is a pyruvate kinase M2 (PKM2) inhibitor with an IC50 of 2.95 ?M[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 94164-88-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103617. | |
| PKN1/2-IN-1 | PKN1/2-IN-1 is a potent, cell penetrant and selective PKN2 (PRK2) inhibitor (IC50=16 nM; Ki=8 nM)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 942425-34-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145899. | |
| PKR activator 3 | PKR activator 3 is a pyruvate kinase isoform PKR activator extracted from patent WO2014139144A1, compound 160. PKR activator 3 can be used for the research of PKR function related diseases, including cancer, diabetes, obesity, autoimmune disorders, and benign prostatic hyperplasia [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1628428-01-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19702. | |
| PKR-IN-C16 | PKR-IN-C16 (Compound C16) is a specific double-stranded RNA-dependent protein kinase (PKR) inhibitor. PKR-IN-C16 shows promising neuroprotective properties and can rescue acute brain lesions[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 608512-97-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13977A. | |
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