MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| PKSI-527 | PKSI-527 is a new, highly selective plasma kallikrein inhibitor. PKSI-527 can suppress collagen-induced arthritis (CIA) by modifying the kallikrein-kinin system [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 128837-71-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123133. |  |
| PKUMDL-WQ-2101 | PKUMDL-WQ-2101 is a non-NAD+-competing allosteric phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 34.8 ?M. PKUMDL-WQ-2101 exhibits antitumor activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 304481-72-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123269. | |
| Pladienolide B | Pladienolide B is a potent cancer cell growth inhibitor that targets the SF3B1 subunit of the spliceosome. Pladienolide B exerts antitumor activities mediated through the inhibition of pre-mRNA splicing. Pladienolide B induces apoptosis [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 445493-23-2. Pack Sizes: 100 μg; 500 μg. Product ID: HY-16399. | |
| Plamotamab | Plamotamab (XmAb-13676) is a human bispecific antibody (bsAb) that binds CD3 and CD20. Plamotamab recruits cytotoxic T cells to kill CD20 + expressing tumor cells. Plamotamab induces a mild hematologic reaction (MR), and results in tumor regression in vivo [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: XmAb-13676. CAS No. 2138442-31-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99776. | |
| Plantaricin A | Plantaricin A is an antimicrobial peptide derived from LactobacifZus plantarum against bacteria [1]. Uses: Scientific research. Group: Peptides. Alternative Names: PlnA. CAS No. 131463-18-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5589. | |
| Plasmin, Human plasma | Plasmin, Human plasma is an important protease present in blood that degrades many plasma proteins, including fibrin clots. Plasmin can also act as a potent regulator of the immune process and can directly interact with various cell types, including monocytes, macrophages, and dendritic cells [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Fibrinolysins, Human plasma; Serum tryptase, Human plasma; TAL 05-00018, Human plasma. CAS No. 9001-90-5. Pack Sizes: 100 μg; 500 μg. Product ID: HY-108883. | |
| Plasminogen, Human plasma | Plasminogen, Human plasma is a secreted protein that upon cleavage by urokinase plasminogen activator (uPA) or tissue plasminogen activator (tPA) is converted to plasmin, a broad range protease capable of cleaving fibrin and other ECM components. Plasminogen also is a proinflammatory regulator that accelerates the healing of acute and diabetic wounds. Plasminogen can be used in studies of wound healing, inflammation and hypoplasminogenemia [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9001-91-6. Pack Sizes: 1 mg. Product ID: HY-P2821. | |
| Platycodin D | Platycodin D is a saponin isolated from Platycodon grandiflorus , acts as an activator of AMPKα , with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 58479-68-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 20 mg. Product ID: HY-N1411. | |
| Platyconic acid A | Platyconic Acid A is an active component of changkil saponins from platycodon grandiflorum and can be used for the research of reducing airway inflammation [1]. Uses: Scientific research. Group: Natural products. CAS No. 68051-23-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N9377. | |
| Plecanatide | Plecanatide, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC 50 of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis [1] [2] [3]. Uses: Scientific research. Group: Peptides. CAS No. 467426-54-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-108741. | |
| Plecanatide acetate | Plecanatide acetate, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide acetate activates GC-C receptors to stimulate cGMP synthesis with an EC 50 of 190 nM in T84 cells assay. Plecanatide acetate can be used for the research of chronic idiopathic constipation, and it also shows anti-inflammatory activity in models of murine colitis [1] [2] [3]. Uses: Scientific research. Group: Peptides. CAS No. 1075732-84-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-108741A. | |
| Pleconaril | Pleconaril is a picornavirus capsid binding inhibitor that prevents attachment and/or virus uncoating. Pleconaril has potential for use in rhinoviruses and enteroviruses research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VP 63843; Win 63843. CAS No. 153168-05-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-19952. | |
| Plerixafor | Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC 50 of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC 50 of 1-10 nM [1] [2] [3] [4] [7]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AMD 3100; JM3100; SID791. CAS No. 110078-46-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10046. | |
| Plerixafor octahydrochloride | Plerixafor octahydrochloride (AMD3100 octahydrochloride) is a selective CXCR4 antagonist with an IC50 of 44 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AMD3100 octahydrochloride; JM3100 octahydrochloride; SID791 octahydrochloride. CAS No. 155148-31-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50912. | |
| Pleuromutilin | Pleuromutilin (Drosophilin B) exhibits antibacterial activity through inhibition of protein synthesis [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Drosophilin B; Mutilin 14-glycolate. CAS No. 125-65-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-N2301. | |
| PLGA (50:50) | PLGA (50:50) (poly(lactic-co-glycolic acid) (50:50)) is a copolymer of poly lactic acid (PLA) and poly glycolic acid (PGA) which can be used to fabricate devices for drug delivery and tissue engineering applications. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: poly(lactic-co-glycolic acid) (50:50). CAS No. 34346-01-5. Pack Sizes: 500 mg; 1 g. Product ID: HY-B2247. | |
| PLGA (75:25) | PLGA (75:25) is a low toxicity, biocompatible and biodegradable controlled drug delivery carrier, can achieve slow release in the organism. PLGA (75:25) is a copolymer of 75% poly lactic acid (PLA) and 25% poly glycolic acid (PGA). PLGA (75:25) has been extensively studied as delivery vehicles for agents, proteins and various other macromolecules such as DNA, RNA and peptides[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: poly(lactic-co-glycolic acid) (75:25). CAS No. 34346-01-5. Pack Sizes: 100 mg; 500 mg. Product ID: HY-B2247A. | |
| Plicamycin | Plicamycin (Mithramycin A) is a selective specificity protein 1 ( Sp1 ) inhibitor. Plicamycin inhibits the growth of various cancers by decreasing Sp1 protein. Plicamycin inhibits GSTM2 promoter activity and protein expression [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Mithramycin A. CAS No. 18378-89-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0122. | |
| Plinabulin | Plinabulin (NPI-2358) is a vascular disrupting agen ( VDA ) against tubulin-depolymerizing with an IC 50 of 9.8 nM against HT-29 cells [1]. Plinabulin binds the colchicine binding site of β-tubulin preventing polymerization and has potent inhibitory to tumor cells [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NPI-2358. CAS No. 714272-27-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14444. | |
| Plitidepsin | Plitidepsin (Aplidine) is a potent anti-cancer agent by targeting eEF1A2 ( K D =80?nM) [1]. Plitidepsin possesses antiviral activity and is against SARS-CoV-2 with an IC 90 of 0.88 nM. Plitidepsin is usually used for multiple myeloma and advanced cancer research, and has the potential for COVID-19 research [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: Aplidine; PM90001. CAS No. 137219-37-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16050. | |
| Plixorafenib | PLX8394 is a potent and selective BRaf inhibitor, with an IC 50 of appr 5 nM for BRAF V600E. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PLX8394; FORE8394. CAS No. 1393466-87-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18972. | |
| PLN-1474 | PLN-1474 (compound 1) is an orally active and selective ???1 integrin inhibitor with an IC50 value of <50 nM. PLN-1474 reduces levels of pSMAD3/SMAD3 in liver, hepatic collagen gene expression and hepatic OHP concentration in liver fibrosis mouse model. PLN-1474 can be used for the research of preventing, delaying or researching a fibrotic or cirrhotic disease or disorder. Uses: Scientific research. Group: Signaling pathways. CAS No. 2408065-32-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-47888. | |
| Plogosertib | Plogosertib (CYC140) is a selective, potent, and orally active ATP-competitive PLK1 inhibitor (IC50: 3 nM). Plogosertib is an anti-cancer agent with anti-proliferative activity. Plogosertib can be used in the research of several tumors, including esophageal, gastric, leukemia, non-small cell lung cancer, ovarian, and squamous cell cancers[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CYC140. CAS No. 1137212-79-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147298. | |
| Plozalizumab | Plozalizumab (MLN-1202) is a specific humanized anti- CCR2 antibody. Plozalizumab can be used for malignant melanoma research [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MLN-1202. CAS No. 1610761-46-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99781. | |
| PLP (139-151) | PLP (139-151) is amino acid residue 139 to 151 of myelin proteolipid protein (PLP) used to induce experimental autoimmune encephalomyelitis (EAE). Uses: Scientific research. Group: Peptides. CAS No. 131334-43-5. Pack Sizes: 5 mg. Product ID: HY-P0129. | |
| PLP (180-199) TFA | PLP (180-199) TFA is the TFA salt form of PLP (180-199) (HY-P5462). PLP (180-199) TFA induces the activation and differentiation of T cells, and induces the experimental autoimmune encephalomyelitis (EAE) in mouse model[1]. Uses: Scientific research. Group: Peptides. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P5462A. | |
| PLpro inhibitor | PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with an IC 50 of 2.6 μM [1]. PLpro inhibitor inhibits SARS-CoV-2 PLpro with an IC 50 of 5.0 μM and an EC 50 of 21.0 μM [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1093070-14-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17542. | |
| Plumbagin | Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica , exhibits anticancer and antiproliferative activities [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 2-Methyljuglone. CAS No. 481-42-5. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-N1497. | |
| Pluripotin | Pluripotin is a dual inhibitor of ERK1 and RasGAP with K D s of 98 nM and 212 nM, respectively. Pluripotin also inhibits RSK1 , RSK2 , RSK3 , and RSK4 with IC 50 s of 0.5, 2.5, 3.3, and 10.0 μM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SC1. CAS No. 839707-37-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10579. | |
| PluriSIn 1 | PluriSIn 1 (NSC 14613) is an inhibitor of stearoyl-coA desaturase (SCD), and is a pluripotent cell-specific inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 14613. CAS No. 91396-88-2. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-15700. | |
| PLX-3618 | PLX-3618 is a molecular glue, that degrades BRD4 with DC50 of 12.2 nM. PLX-3618 promotes polyubiquitination and subsequent proteasomal degradation of BRD4 by recruiting of the E3 ligase substrate receptor, DCAF11. PLX-3618 inhibits the proliferation of various cancer cells, induces apoptosis in AML cells. PLX-3618 exhibits antitumor activity against AML in mouse models[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2851986-76-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-161779. | |
| PLX-4720 | PLX-4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), and 10-fold selectivity for B-RafV600E than wild-type B-Raf. Uses: Scientific research. Group: Signaling pathways. CAS No. 918505-84-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-51424. | |
| PLX51107 | PLX51107 is a potent and selective BET inhibitor, with Kds of 1.6, 2.1, 1.7, and 5 nM for BD1 and 5.9, 6.2, 6.1, and 120 nM for BD2 of BRD2, BRD3, BRD4, and BRDT, respectively; PLX51107 also interacts with the bromodomains of CBP and EP300 (Kd, in the 100 nM range). Uses: Scientific research. Group: Signaling pathways. CAS No. 1627929-55-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111422. | |
| PLX5622 | PLX5622 is a highly selective brain penetrant and orally active CSF1R inhibitor (IC50=0.016 ?M; Ki=5.9 nM). PLX5622 allows for extended and specific microglial cells elimination, preceding and during pathology development. PLX5622 demonstrates desirable PK properties in varies animals. PLX5622 is predominantly administered via ad libitum diets with a dose of 1200 ppm[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1303420-67-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114153. | |
| PLX5622 hemifumarate | PLX5622 hemifumarate is a highly selective brain penetrant and orally active CSF1R inhibitor (IC50=0.016 ?M; Ki=5.9 nM). PLX5622 hemifumarate allows for extended and specific microglial elimination, preceding and during pathology development. PLX5622 hemifumarate demonstrates desirable PK properties in varies animals[1][2]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114153A. | |
| PLX7904 | PLX7904 is a potent and selective BRAF inhibitor, with IC50 of appr 5 nM against BRAFV600E in mutant RAS expressing cells. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PB04. CAS No. 1393465-84-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18997. | |
| PM-1 | PM-1, a derivative of Thioflavin-T (ThT; HY-D0218), is a small but highly specific plasma membrane (PM) fluorescent dye for specific and long-time membrane imaging of living and fixed cells. PM-1 is embedded directly into the cell membrane and exhibits a very long retention time on the plasma membrane with a half-life of approximately 15 h. PM-1 can be used in combination with protein labeling probes to study ectodomain shedding and endocytosis processes of cell surface proteins [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 1449483-78-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156404. | |
| PMSF | PMSF is an irreversible serine/cysteine protease inhibitor commonly used in the preparation of cell lysates. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Phenylmethylsulfonyl fluoride; Benzylsulfonyl fluoride. CAS No. 329-98-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0496. | |
| PMX 205 Trifluoroacetate | PMX 205 Trifluoroacetate is a specific complement C5aR1 isoform antagonist[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110136A. | |
| PMX-53 | PMX-53 (3D53) is a synthetic peptidic and a potent and orally active complement C5a receptor (CD88) antagonist with an IC50 of 20 nM. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. PMX-53 specifically binds to C5aR1 and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects[1][2][3][4][5][6]. Uses: Scientific research. Group: Peptides. Alternative Names: 3D53. CAS No. 219639-75-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106178. | |
| PNC-27 acetate | PNC-27 acetate, a chimeric p53-penetratin peptide binds to HDM-2 in a p53 peptide-like structure, induces selective membrane-pore formation and leads to cancer cell lysis. PNC-27 acetate is an anticancer peptide. PNC-27 acetate can be used in acute myeloid leukemia research[1][2][3]. Uses: Scientific research. Group: Peptides. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P3508A. | |
| PND-1186 | PND-1186 (VS-4718) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 selectively promotes tumor cell apoptosis[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VS-4718; SR-2516. CAS No. 1061353-68-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13917. | |
| Pneumocandin B0 | Pneumocandin B0 (L-688786), the precursor of the antifungal agent Caspofungin acetate, is an antifungal agent belonging to the echinocandin family. Pneumocandin B0, derived from the flamentous fungus Glarea lozoyensis , is a synthetic intermediate of Cancidas [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: L-688786. CAS No. 135575-42-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-17578. | |
| PNGase F | PNGase F, a glycosidase, catalyzes the cleavage of an internal glycoside bond in an oligosaccharide. PNGase F removes nearly all N-linked oligosaccharides from glycoproteins. PNGase F can release N-glycans from glycoproteins in glycoanalytical workflows [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 83534-39-8. Pack Sizes: 10 KU. Product ID: HY-P2929. | |
| p-Nitrobenzyl mesylate | p-Nitrobenzyl mesylate (4-Nitrobenzyl mesylate; para-Nitrobenzyl mesylate) is a reagent used to alkylate phosphorothioates, forming phosphorothioate epitopes that can be recognized by specific antibodies. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4-Nitrobenzyl mesylate; para-Nitrobenzyl mesylate; PNBM. CAS No. 39628-94-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118380. | |
| p-nitro-Pifithrin-α | p-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent p53 inhibitor. p-nitro-Pifithrin-α suppresses p53-mediated TGF-β1 expression in HK-2 cells. p-nitro-Pifithrin-α inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice fed a high-fat diet [4]. non-alcoholic fatty liver disease [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 389850-21-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-130437. | |
| PNPP disodium | PNPP (Para-nitrophenyl phosphate) disodium is a non-proteinaceous chromogenic substrate for alkaline and acid phosphatases used in ELISA and conventional spectrophotometric assays. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Para-nitrophenyl phosphate disodium. CAS No. 4264-83-9. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-15928. | |
| PNT6555 | PNT6555 is a fibroblast activation protein-α ( FAP ) inhibitor. PNT6555 has antitumor activity. PNT6555 can be used for imaging of FAP -positive tumors [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2715113-34-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-161074. | |
| PNU-120596 | PNU-120596 (NSC 216666) is a potent and selective α7 nAChR positive allosteric modulator (PMA) with an EC 50 of 216 nM. PNU-120596 is inactive against α4β2, α3β4, and α9α10 nAChRs. PNU-120596 has the potential for psychiatric and neurological disorders research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 216666. CAS No. 501925-31-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12152. | |
| PNU-142633 | PNU-142633 is a high affinity, selective and orally active 5-HT 1D receptor agonist with K i s of 6 nM and > 18 000 nM for human 5-HT 1D receptor and human 5-HT 1B receptor, respectively. PNU-142633 has anti-migraine efficacy [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 187665-65-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-103131. | |
| PNU-159682 | PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance. Uses: Scientific research. Group: Signaling pathways. CAS No. 202350-68-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16700. | |
| PNU-22394 hydrochloride | PNU-22394 hydrochloride is an agonist for 5-HT , with K i of 6.1 and 10 nM, for 5-HT 2C and 5-HT 2A , respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 15923-42-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-103145. | |
| PNU-282987 | PNU-282987 is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC 50 of 154 nM. PNU-282987 is also a functional antagonist of the 5-HT 3 receptor with an IC 50 of 4541 nM. PNU-282987 can be used for the research of central and peripheral nervous systems [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 123464-89-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12560A. | |
| PNU-74654 | PNU-74654 is an inhibitor of Wnt/β-catenin pathway with an IC 50 of 129.8 μM in NCI-H295 cell. Uses: Scientific research. Group: Signaling pathways. CAS No. 113906-27-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-101130. | |
| Pociredir | Pociredir (FTX-6058) is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). Pociredir can induce HbF protein expression in cell and murine models. Pociredir can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FTX-6058. CAS No. 2490676-18-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-139400. | |
| Pociredir hydrochloride | Pociredir (FTX-6058) hydrochloride is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). Pociredir hydrochloride can induce HbF protein expression in cell and murine models. Pociredir hydrochloride can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FTX-6058 hydrochloride. CAS No. 2490676-19-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139400A. | |
| Podofilox | Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II. Uses: Scientific research. Group: Natural products. Alternative Names: Podophyllotoxin. CAS No. 518-28-5. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-15552. | |
| Podophyllotoxone | Podophyllotoxone is isolated from the roots of Dysosma versipellis and has anti-cancer activities.Podophyllotoxone is able to inhibit the tubulin polymerization [1]. Uses: Scientific research. Group: Natural products. CAS No. 477-49-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N2415. | |
| Polaprezinc | Polaprezinc is an orally bioavailable chelate composed of zinc and L-carnosine, with potential gastroprotective, anti-oxidant, anti-ulcer and anti-inflammatory activities. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Zinc L-carnosine. CAS No. 107667-60-7. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0729. | |
| Polatuzumab | Polatuzumab is a monoclonal antibody, which targets CD79b that is found on the surface of B cells. Polatuzumab sticks to the CD79b protein and delivers the chemotherapy compound into the cell. Polatuzumab can be used to synthesize Polatuzumab Vedotin, which is an antibody-drug conjugate (ADC) targeting CD79b [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2279068-37-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99042. | |
| Polatuzumab vedotin | Polatuzumab vedotin is an antibody-drug conjugate targeting CD79b. It contains a humanized anti-CD79b IgG1 monoclonal antibody linked to monomethyl auristatin E (MMAE), a potent microtubule inhibitor. Polatuzumab vedotin has the potential for the research of Large B-cell lymphomas (LBCL) [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 1313206-42-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-132253. | |
| Polatuzumab vedotin (solution) | Polatuzumab vedotin solution is an antibody-drug conjugate targeting CD79b. It contains a humanized anti-CD79b IgG1 monoclonal antibody linked to monomethyl auristatin E (MMAE), a potent microtubule inhibitor. Polatuzumab vedotin solution has the potential for the research of Large B-cell lymphomas (LBCL) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1313206-42-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-132253A. | |
| Policresulen | Policresulen is a potent inhibitor of DENV2 NS2B/NS3 protease ( IC 50 of 0.48 μg/mL). Policresulen inhibits DENV2 replication in BHK-21 cells with IC 50 of 4.99 μg/mL. Policresulen acts as a competitive inhibitor of the protease, and slightly affects the protease stability [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 101418-00-2. Pack Sizes: 1 g; 5 g. Product ID: HY-W129596. | |
| Polidocanol,Hydroxyl Value 40-60 mgKOH/g | Polidocanol is a sclerosing agent used successfully to treat extremity and esophageal varices and telangiectasias. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Polyoxyethylene lauryl ether; Polyoxyethyleneglycol Dodecyl Ether. CAS No. 9002-92-0. Pack Sizes: 500 mg; 1 g; 5 g. Product ID: HY-B2106. | |
| Polistes mastoparan | Polistes mastoparan is an antimicrobial peptide. Polistes mastoparan increases S. aureus cell K + efflux and inhibits cell viability with EC 50 of 5 μM [1]. Uses: Scientific research. Group: Peptides. CAS No. 74129-19-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2576. | |
| Poloxamer 188 | Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models. Poloxamer 188 can be used for drug delivery [1] [2] [3] [4]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: PEG-PPG-PEG, 8800 (Average Mn). CAS No. 9003-11-6. Pack Sizes: 500 mg; 1 g; 5 g; 10 g. Product ID: HY-D1005A. | |
| Poloxamer 188 (F68) | Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: PEG-PPG-PEG, 8400(Average Mn). CAS No. 9003-11-6. Pack Sizes: 500 mg; 1 g. Product ID: HY-D1005H. | |
| Poloxamer 407 (F127) | Poloxamer 407 (F127) is a nonionic surfactant that is 100% active and relatively non-toxic to cells at low concentrations, and frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, Quest Fluo-8 AM and Quest Rhod-4 AM, etc. to improve their water solubility. Poloxamer 407 is also a lipoprotein lipase inhibitor [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: PEG-PPG-PEG, 12600 (Average Mn). CAS No. 9003-11-6. Pack Sizes: 500 mg; 1 g; 5 g. Product ID: HY-D1005. | |
| Poloxin | Poloxin is a non-ATP competitive Polo-like Kinase 1 (PLK1) inhibitor that targets the polo-box domain, with an IC50 of appr 4.8 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 321688-88-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-12134. | |
| PolQi1 | PolQi1 is a Pol? (polymerase theta) inhibitor. PolQi1 targets the polymerase domain of the enzyme [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2607139-80-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-159078. | |
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