MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Setipiprant | Setipiprant (ACT-129968) is an orally active and selective CRTH2 antagonist. Setipiprant interacts with hCRTH2 receptor with an IC 50 value of 6 nM. Setipiprant inhibits prostanoid receptors h DP 1 and h EP 2 with IC 50 values of 1290 and 2600 nM, respectively. Setipiprant can be used for the research of asthma and rhinitis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ACT-129968; KYTH-105. CAS No. 866460-33-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16635. |  |
| Setiptiline | Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Org-8282. CAS No. 57262-94-9. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-32329. | |
| Setiptiline maleate | Setiptiline maleate (MO-8282 maleate) is a serotonin receptor antagonist. Setiptiline maleate is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline maleate acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT 2A , 5-HT 2C , and/or 5-HT 3 subtypes, as well as an H1 receptor inverse agonist/antihistamine [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MO-8282. CAS No. 85650-57-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-32329A. | |
| Setmelanotide | Setmelanotide (RM-493) is a selective melanocortin 4 receptor ( MC4R ) agonist with EC 50 s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively [1]. Uses: Scientific research. Group: Peptides. Alternative Names: RM-493; BIM-22493; IRC-022493. CAS No. 920014-72-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19870. | |
| (S)-(+)-Etomoxir | (S)-(+)-Etomoxir is the S enantiomer of Etomoxir (HY-50202). Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1a ( CPT-1a ), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 828934-40-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-W420033. | |
| Setrusumab | Setrusumab (BPS 804) is a fully human monoclonal antibody targets sclerostin. Setrusumab efftively improves bone strength. Setrusumab can be used for the resesrch of Osteogenesis Imperfecta (OI) and cancer [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BPS 804. CAS No. 1847394-95-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99398. | |
| Sevasemten | Sevasemten is an orally active allosteric inhibitor of skeletal muscle myosin that protects skeletal muscle from contraction-induced injury. Sevasemten exhibits selectively myosin inhibition with IC 50 s of ≤10 μM (skeletal), >100 μM (cardiac), respectively. Sevasemten decreases muscle damage biomarkers and fibrosis while increasing muscle strength and activity in in Duchenne muscular dystrophy disease models [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2417395-15-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148799. | |
| Sevelamer carbonate | Sevelamer carbonate is an orally active and non-calcium-based phosphate binding agent and used for the hyperphosphatemia of chronic kidney disease (CKD)research. Sevelamer carbonate effectively lowers serum phosphorus levels hile having minimal effect on serum calcium or serum chloride levels in vivo. Sevelamer carbonate is considered as an improved, buffered form of sevelamer (HY-13995) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 845273-93-0. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-13995B. | |
| Sevelamer hydrochloride | Sevelamer hydrochloride is an orally active and phosphate binding agent used for research of hyperphosphatemia with chronic kidney disease. Sevelamer hydrochloride consists of polyallylamine that is crosslinked with epichlorohydrin [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 152751-57-0. Pack Sizes: 100 mg; 500 mg. Product ID: HY-13995A. | |
| Seviteronel | Seviteronel (VT-464) is a potent CYP17 lyase inhibitor(h-Lyase IC 50 =69 nM) and an AR antagonist. Seviteronel demonstrates both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VT-464. CAS No. 1610537-15-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15996. | |
| Seviteronel racemate | Seviteronel racemate (VT-464 racemate) is the racemate form of Seviteronel (VT-464), which is a potent CYP17 lyase inhibitor(h-Lyase IC 50 =nM)inhibition. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VT-464 (racemate). CAS No. 1375603-36-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15996B. | |
| SEW?2871 | SEW2871 is an orally active, potent, highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist, with an EC 50 of 13.8 nM. SEW2871 activates ERK , Akt , and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte numbers in blood. SEW2871 can be used for the research of diabetes, Alzheimers disease, liver fibrosis, and inflammatory responses [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 256414-75-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-W008947. | |
| SF 11 | SF 11 is a potent and brain penetrant neuropeptide Y Y2 receptor antagonist ( IC 50 =199 nM). Antidepressant-like activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 443292-81-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107731. | |
| SF1670 | SF1670 is a potent and specific phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 345630-40-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15842. | |
| SF-22 | SF-22 is a potent and brain-penetrant antagonist of neuropeptide Y receptor (Y2R), with the IC 50 value of 750 nM. SF-22 plays an important role in neurological disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 824981-55-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132240. | |
| SF2523 | SF2523 is a highly selective and potent inhibitor of PI3K with IC50s of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for PI3K?, PI3K?, DNA-PK, BRD4 and mTOR, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1174428-47-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101146. | |
| SF5 | SF5 (2,2-Diphenylethyl isothiocyanate) is a sulforaphane analog. SF5 inhibits apoptosis by the JNK-p53-caspase pathway. SF5 can be used as a new renal protective agent for drug-resistant acute renal disease [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2,2-Diphenylethyl isothiocyanate. CAS No. 34634-22-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116794. | |
| SFI003 | SFI003 is a SRSF3 inhibitor that drives CRC cell apoptosis via the SRSF3/DHCR24/ROS axis and exhibits potent antitumor effects both in vitro and in vivo[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2361332-90-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148660. | |
| (S)-Fluoxetine hydrochloride | (S)-Fluoxetine hydrochloride, an antidepressant, is serotonin reuptake inhibitor (SSRI) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 114247-06-2. Pack Sizes: 1 mg. Product ID: HY-B0102B. | |
| (S)-Flurbiprofen | (S)-Flurbiprofen is an active enantiomer of Flurbiprofen, with IC 50 values of 0.48 μM and 0.47 μM for COX-1 and COX-2 , respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Esflurbiprofen. CAS No. 51543-39-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg. Product ID: HY-15123. | |
| SFTI-1 | SFTI-1 is a cyclic peptide trypsin inhibitor consisting of 14 amino acid residues. SFTI-1 belongs to the Bowman-Birk class of inhibitors. Characterized by its small size, high stability, and potent activity, SFTI-1 can be used for research on peptide drug design platforms[1][2]. Uses: Scientific research. Group: Peptides. CAS No. 245080-24-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P10033. | |
| SG-094 | SG-094 is a potent TPC2 inhibitor with antiproliferative effects. SG-094 can be used for the research of cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2922283-37-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148816. | |
| SG3199 | SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249)[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1595275-71-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-101161. | |
| SGC0946 | SGC0946 is a selective DOT1L H3K79 methyltransferase ) inhibitor, with an IC 50 of 0.3 nM. SGC0946 results in G1 arrest, inhibits potential of cell self-renewal and metastatic, also induces cell differentiation. SGC0946 can be used in studies of leukemia and solid tumors and also serve as a probe to further investigate the cellular mechanism of DOT1L in both normal and diseased cells [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1561178-17-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-15650. | |
| SGC2085 | SGC2085 is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 ( CARM1 ) with an IC 50 of 50 nM. SGC2085 also selectively inhibits PRMT6 with an IC 50 value of 5.2 μM, but not other PRMT proteins [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1821908-48-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100565. | |
| SGC3027 | SGC3027 is a histone methyltransferase inhibitor[1]. SGC3027 is the first potent, selective and cell active chemical probe for PRMT7[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2624313-13-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112445. | |
| SGC707 | SGC707 is a potent, selective, and non-competitive PRMT3 (protein arginine methyltransferase 3) inhibitor (IC50=31 nM, Kd=53 nM). Uses: Scientific research. Group: Signaling pathways. CAS No. 1687736-54-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-19715. | |
| SGC-AAK1-1 | SGC-AAK1-1 is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor with an IC 50 of 270 nM and a K i of 9 nM. SGC-AAK1-1 also potently inhibits BMP2K. SGC-AAK1-1 is used to study Wnt pathway related to AAK1 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2247894-32-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123940. | |
| SGC-CBP30 | SGC-CBP30 is a potent and highly selective CBP/p300 bromodomain (Kds of 21 nM and 32 nM for CBP and p300, respectively) inhibitor, displaying 40-fold selectivity over the first bromodomain of BRD4 [BRD4(1)] bound. SGC-CBP30 strongly reduces secretion of IL-17A in Th17 cells and has anti-inflammatory effects[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1613695-14-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15826. | |
| SGC-CK2-1 | SGC-CK2-1 is a highly potent, ATP-competitive, and cell-active CK2 chemical probe with exclusive selectivity for both human CK2 isoforms, with IC 50 s of 36 and 16 nM for CK2α and CK2αrespectively in the nanoBRET assay. SGC-CK2-1 can be used for the research of neurodegenerative diseases [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2470424-39-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139004. | |
| SGC-GAK-1 | SGC-GAK-1 is a potent, selective cyclin G-associated kinase (GAK) inhibitor with a Ki of 3.1 nM. SGC-GAK-1 is a chemical probe for GAK[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2226517-76-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122186. | |
| SGC-STK17B-1 | SGC-STK17B-1 is an ATP-competitive and selective STK17B (a member of DAPK family) inhibitor ( IC 50 : 34 nM, K D : 5.6 nM) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2650530-00-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-156350. | |
| SGD-1882 | SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PBD dimer. CAS No. 1222490-34-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-101127. | |
| SGD-1910 | SGD-1910 is a agent-linker conjugate for ADC by using the antitumor antibiotic, pyrrolobenzodiazepine (PBD, a cytotoxic DNA crosslinking), linked via the cleavable linker MC-Val-Ala[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1342820-51-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-101162. | |
| SGF29-IN-1 | SGF29-IN-1 (Compound Cpd_DC60) is a selective inhibitor for Spt-Ada-Gcn5 acetyltransferase (SAGA)-associated factor 29 (SGF29)-Tudor domain. SGF29-IN-1 exhibits activity against leukemia[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 6638-82-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158009. | |
| SGI-1027 | SGI-1027 is a DNA methyltransferase (DNMT) inhibitor, with IC50s of 7.5 ?M, 8 ?M, and 12.5 ?M for DNMT3B, DNMT3A, and DNMT1 with poly(dI-dC) as substrate. Uses: Scientific research. Group: Signaling pathways. CAS No. 1020149-73-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13962. | |
| SGI-1776 free base | SGI-1776 free base is an inhibitor of Pim kinases, with IC 50 s of 7 nM, 363 nM, and 69 nM for Pim-1, -2 and -3, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1025065-69-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13287. | |
| SGK1-IN-1 | SGK1-IN-1 is a highly active and selective inhibitor of SGK-1, with an IC50 of 1 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1279829-87-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18607. | |
| SGLT2-IN-1 | SGLT2-IN-1 (Compound 5) is an inhibitor for sodium-dependent glucose cotransporter ( SGLT2 ), with IC 50 of 33 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 864070-37-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-I1120. | |
| SGN-2FF | SGN-2FF is a potent and orally active inhibitor of fucosylation, directly inhibits fucosyltransferase activity. SGN-2FF possesses antitumor activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2089647-47-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107366. | |
| SGN-B6A | SGN-B6A is an ADC, which targets integrin beta-6 (ITGB6) through human IgG1 monoclonal antibody Sigvotatug (HY-P990764), and exhibits cytotoxicity against multiple integrin beta-6-positive cancer cell through mitotic inhibitor MMAE (HY-15162)[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-164957. | |
| (S)-Gossypol (acetic acid) | (S)-Gossypol is the isomer of a natural product Gossypol. (S)-Gossypol binds to the BH3-binding groove of Bcl-xL and Bcl-2 proteins with high affinity. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (S)-(+)-Gossypol acetic acid. CAS No. 1189561-66-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15464D. | |
| SGR-1505 | SGR-1505 is an orally active MALT1 allosteric inhibitor. SGR-1505 inhibits MALT1 enzymatic activity and shows anti-proliferative activity in BTK inhibitor (BTKi)-sensitive and BTKi-resistant activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) cell lines. SGR-1505 can be used for research of B-cell lymphomas [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2661481-41-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160698. | |
| SGX-523 | SGX523 is a exquisitely selective and ATP-competitive MET inhibitor. SGX523 potently inhibits MET with an IC50 of 4 nM and is >1,000-fold selective versus other protein kinases. Antitumor activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1022150-57-7. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12019. | |
| SH-42 | SH-42 is a potent and selective inhibitor of human ?24-dehydrocholesterol reductase (DHCR24), with an IC50 of 42 nM. SH-42 can lead to a significant increase in plasma desmosterol levels of mice[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2143952-36-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-143228. | |
| SH-4-54 | SH-4-54 is a STAT inhibitor that binds to STAT3 and STAT5 with KDs of 300, 464 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1456632-40-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16975. | |
| SH514 | SH514 is an interferon regulatory factor 4 (IRF4) inhibitor with an IC50 value of 2.63 ?M. SH514 can be bound to the IRF4-DBD domain with KD values of 1.28 ?M. SH514 can be used to study multiple myeloma (MM)[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-172085. | |
| SHA 68 | SHA 68 is a potent and selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC50s of 22.0 and 23.8 nM for NPSR Asn107 and NPSR Ile107, respectively. SHA 68 has limited the blood-brain barrier (BBB) penetration and the activity in neuralgia[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 847553-89-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108625. | |
| Shanzhiside methyl ester | Shanzhiside methy lester is isolated from lamiophlomis rotata. Shanzhiside methyl ester is a small molecule glucagon-like peptide-1 (GLP-1) receptor agonist and has the ability to induce anti-allodynic tolerance [1]. Uses: Scientific research. Group: Natural products. CAS No. 64421-28-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 20 mg. Product ID: HY-N0630. | |
| SH-BC-893 | SH-BC-893 is an orally active anti-neoplastic sphingolipid analog. SH-BC-893 also protects from ceramide-induced mitochondrial dysfunction and corrects diet-induced obesity. SH-BC-893 can be used for the research of cancer and obesity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1841409-92-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-124758. | |
| S-Hexylglutathione | S-Hexylglutathione is an S-substituted glutathione in which the hydrogen of the thiol has been replaced by a hexyl group. S-Hexylglutathione is also an competitive inhibitor against glutathione-S-transferase. S-Hexylglutathione can be used as an affinity chromatographic ligand for glutathione-S-transferase and glutathione peroxidase [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 24425-56-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W013754. | |
| Shield-1 | Shield-1 (Shld1) is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD)[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Shld1. CAS No. 914805-33-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112210. | |
| (S)-Higenamine hydrobromide | (S)-Higenamine ((S)-Norcoclaurine) hydrobromide, a S-enantiomer of Higenamine, is the entry compound in benzylisoquinoline alkaloid biosynthesis. (S)-Higenamine hydrobromide is produced by the condensation of dopamine and 4-hydroxyphenylacetaldehyde (4-HPAA) by norcoclaurine synthase (NCS) [1]. Uses: Scientific research. Group: Natural products. Alternative Names: (S)-Norcoclaurine hydrobromide. CAS No. 105990-27-0. Pack Sizes: 1 mg. Product ID: HY-N2037C. | |
| Shikimic acid | Shikimic acid is a key metabolic intermediate of the aromatic amino acid biosynthesis pathway, found in microbes and plants. Uses: Scientific research. Group: Natural products. CAS No. 138-59-0. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-N0130. | |
| Shikonin | Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC 50 of 6.5 μM [1]. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor [2] and can also inhibit TNF-α and NF-κB pathway [3]. Shikonin decreases exosome secretion through the inhibition of glycolysis [4]. Shikonin inhibits AIM2 inflammasome activation [7]. Uses: Scientific research. Group: Natural products. Alternative Names: C.I. 75535; Isoarnebin 4. CAS No. 517-89-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0822. | |
| SHIN1 | SHIN1 (RZ-2994) is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RZ-2994. CAS No. 2146095-85-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112066. | |
| (-)-SHIN1 | (-)-SHIN1 ((-)-RZ-2994) is an inactive (-) enantiomer of SHIN1 [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (-)-RZ-2994. CAS No. 2444764-09-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112066B. | |
| (+)-SHIN1 | (+)-SHIN1 ((+)-RZ-2994) is an active (+) enantiomer of SHIN1 [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (+)-RZ-2994. CAS No. 2443966-90-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112066A. | |
| (+)SHIN2 | (+)SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor, whose target can be traced with 13C-serine. (+)SHIN2 increases survival in NOTCH1-driven mouse primary acute lymphoblastic leukemia (T-ALL) in vivo with a synergistic effect with Methotrexate (HY-14519)[1]. (+)SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134978A. | |
| SHLP2 | SHLP2 (Small humanin-like peptide 2) is a small molecule peptide encoded by mitochondrial DNA, belonging to mitochondria derived peptide. SHLP2 has the activity of regulating apoptosis and inhibits cell death. SHLP2 can be used in the study of diseases related to mitochondrial dysfunction and anti-aging diseases [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Small humanin-like peptide 2. CAS No. 1191923-93-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P10409. | |
| SHMT-IN-2 | SHMT-IN-2 is a stereo specific inhibitor of human SHMT1/2 with IC50 values of 13 nM and 66 nM for SHMT1 and SHMT2, respectively. SHMT-IN-2 can block the growth of many human cancer cells, and has sensitivity for B-cell lymphomas[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2102681-49-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-129226. | |
| (S)-HN0037 | (S)-HN0037 is the (S)-isomer of HN0037 (HY-163529), a selective and orally active helicase-primase inhibitor that inhibits HSV replication by targeting the viral helicase-primase enzyme complex [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2233566-78-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-163529A. | |
| Shogaol | Shogaol ([6]-Shogaol), an active compound isolated from Ginger ( Zingiber officinale Rosc), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation. Uses: Scientific research. Group: Natural products. Alternative Names: [6]-Shogaol; 6-Shogaol. CAS No. 555-66-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14616. | |
| SHP099 | SHP099 is an allosteric SHP2 inhibitor, with IC50s of 0.690, 1.241, 0.416, 1.968, 2.896 ?M for SHP2, SHP2D61Y, SHP2E69K, SHP2A72V, SHP2E76K. SHP099 inhibits cancer cell growth, such as MV4-11 and TF-1 cell (IC50: 0.32 and 1.73 ?M). SHP099 inhibits RAS-ERK signaling and inhibits tumor growth[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1801747-42-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100388. | |
| SHP099 monohydrochloride | SHP099 hydrochloride is a potent, selective and orally available SHP2 inhibitor with an IC50 of 70 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2200214-93-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100388A. | |
| SHR-1701 | SHR-1701 (Retlirafusp alfa) is a bifunctional fusion protein targeting PD-L1 and TGF-β for cancer research [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Retlirafusp alfa. CAS No. 2891860-17-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99944. | |
| SHU 9119 | SHU 9119 is a potent human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist; with IC50 values of 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively. Uses: Scientific research. Group: Peptides. CAS No. 168482-23-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P0227. | |
| Shz-1 | Shz-1, a small cardiogenic molecule, induces various cardiac-specific genes including sarcomeric tropomyosin in P19CL6 cells. Shz-1 induces Nkx2.5 expression in mouse. Shz-1 activates the axolotl TPM4 promoter-driven ectopic expression in C2C12 cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 326886-05-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108440. | |
| SI-109 | SI-109 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3 ?M). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 degrader SD-36[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2429877-30-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-129603. | |
| SI-113 | SI-113 is a SGK1 inhibitor, with an IC50 of 600 nM. SI113 induces autophagy[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1392816-46-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-117357. | |
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