MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| SB 271046 Hydrochloride | SB 271046 Hydrochloride (SB 271046A) is a potent, selective and orally active 5-HT6 receptor antagonist with pK i of 9.02, 8.55, and 8.81 for rat, pig and human, respectively. SB 271046 Hydrochloride is over 200 fold selective for the 5-HT6 receptor vs 55 other receptors, binding sites and ion channels. Anticonvulsant activity (EC 50 =0.16 μM) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB 271046A. CAS No. 209481-24-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-14336A. |  |
| SB-273005 | SB-273005 is an orally active non-peptide ?v?3 integrin antagonist with Ki values of 1.2 nM and 0.3 nM for ?v?3 and ?v?5, respectively. SB-273005 blocks the binding of integrins to the RGD sequence in the extracellular matrix. SB-273005 inhibits Rictor phosphorylation and reduces IL-10 secretion. SB-273005 inhibits inflammation, prevents bone loss, regulates vascular smooth muscle function, and reverses pregnancy-induced immune deviation. SB-273005 can be used in the study of rheumatoid arthritis, osteoporosis, and aneurysms. [1][2][3][4][5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 205678-31-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19307. | |
| SB-277011 hydrochloride | SB-277011 hydrochloride (SB-277011A hydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D 3 receptor (D 3 R) antagonist with K i values of 10.7 nM and 11.2 nM at rodent and human D 3 R, respectively. SB-277011 hydrochloride displays 80- to 100-fold selectivity over other dopamine receptors with pK i s of 8.0, 6.0, <5.2, and 5.9 for D3, D2, 5-HT 1B , and 5-HT 1D receptors, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB-277011A hydrochloride. CAS No. 215804-67-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10847B. | |
| SB290157 trifluoroacetate | SB290157 trifluoroacetate is a potent and selective C3a receptor antagonist with an IC50 of 200 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1140525-25-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101502A. | |
| SB-328437 | SB-328437 is a potent, selective non-peptide CCR3 antagonist with an IC 50 of 4.5 nM. SB-328437 can inhibit eosinophil migration induced by eotaxin, eotaxin-2, and monocyte chemotactic protein-4. In addition, SB-328437 can sensitize 5-FU (HY-90006)-resistant gastric cancer cells. SB-328437 can also reduce the recruitment of neutrophils to the lungs and pulmonary inflammation during acute inflammation. SB-328437 can be used in the research of inflammation-related diseases [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 247580-43-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103363. | |
| SB-334867 | SB-334867 (SB 334867A) is an excellent,selective and blood - brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 ( pK b =7.4), 100-fold over 5-HT 2B , 5-HT 2C with pK i values of 5.4 and 5.3, respectively [1]. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB 334867A. CAS No. 249889-64-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10895. | |
| SB-334867 free base | SB-334867 free base (SB334867A free base) is an excellent, selective and blood - brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 ( pK b =7.4), 100-fold over 5-HT 2B , 5-HT 2C with pK i values of 5.4 and 5.3, respectively [1]. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB334867A free base. CAS No. 792173-99-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10895A. | |
| SB-366791 | SB-366791 is a potent and selective vanilloid receptor ( VR1/TRPV1 ) antagonist ( IC 50 =5.7 nM). SB-366791 can be used for the research of inflammation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 472981-92-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12245. | |
| SB-399885 hydrochloride | SB-399885 hydrochloride is a 5-HT 6 receptor antagonist. Uses: Scientific research. Group: Signaling pathways. CAS No. 402713-81-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103099. | |
| SB-3CT | SB-3CT is a potent and competitive matrix metalloproteinase MMP-2 and MMP-9 inhibitor with Ki values of 13.9 and 600 nM, respectively. SB-3CT has high selectivity for gelatinases. SB-3CT shows blood-brain barrier permeability and has neuroprotective effects and anticancer activity[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 292605-14-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-12354. | |
| SB-408124 | SB-408124 is a non-peptide OX1 receptor antagonist with K i s of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 exhibits 50-fold selectivity over OX2 receptor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 288150-92-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 100 mg. Product ID: HY-70068. | |
| SB-408124 Hydrochloride | SB-408124 Hydrochloride is a selective non-peptide orexin receptor 1 (OX1) receptor antagonist with K i s of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 Hydrochloride exhibits 50-fold selectivity over OX2 receptor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1431697-90-3. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-76612. | |
| SB 415286 | SB 415286 is a potent and selective cell permeable inhibitor of GSK-3α , with an IC 50 of 77.5 nM, and a K i of 30.75 nM; SB 415286 is equally effective at inhibiting human GSK-3α and GSK-3&beta. Uses: Scientific research. Group: Signaling pathways. CAS No. 264218-23-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15438. | |
| SB-431542 | SB-431542 is a TGF-β receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC 50 values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 301836-41-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10431. | |
| SB-431542 (GMP) | SB-431542 (GMP) is SB-431542 (HY-10431) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SB-431542 is a TGF-? receptor kinase inhibitor (TRKI) in SMAD signaling[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 301836-41-9. Pack Sizes: 10 mg; 50 mg; 100 mg. Product ID: HY-10431G. | |
| SB-431542 (Standard) | SB-431542 (Standard) is the analytical standard of SB-431542. SB-431542 is a TGF-β receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC 50 values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 301836-41-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-10431R. | |
| SB-505124 | SB-505124 is a selective inhibitor of TGF-? Receptor type I receptors (ALK4, ALK5, ALK7), with IC50s of 129 nM and 47 nM for ALK4, ALK5, respectively, but it does not inhibit ALK1, 2, 3, or 6. Uses: Scientific research. Group: Signaling pathways. CAS No. 694433-59-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13521. | |
| SB 525334 | SB 525334 is a potent and selective transforming growth factor β1 receptor (ALK5) inhibitor with an IC 50 of 14.3 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 356559-20-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12043. | |
| SB-590885 | SB-590885 is a potent B-Raf inhibitor with a K i of 0.16 nM, and has 11-fold greater selectivity for B-Raf over c-Raf, without inhibition to other human kinases. Uses: Scientific research. Group: Signaling pathways. CAS No. 405554-55-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10966. | |
| SB-612111 hydrochloride | SB-612111 hydrochloride hydrochloride is a novel and potent opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (Ki=0.33 nM). SB-612111 hydrochloride exhibits selectivity for ?-,??- and??-receptors with Ki values of?57.6 nM, 160.5 nM and 2109 nM, respecticely. SB-612111 hydrochloride effectively antagonizes the pronociceptive action of Nociceptin (HY-P0183) in an acute pain model[1].. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18618A. | |
| SB-633825 | SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC50s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 956613-01-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108333. | |
| SB-649868 | SB-649868 is a potent and selective orally active orexin ( OX ) 1 and OX 2 receptor antagonist ( pK i =9.4 and 9.5 at the OX 1 and OX 2 receptor, respectively). Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK649868. CAS No. 380899-24-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10806. | |
| SB-674042 | SB-674042 is a potent and selective non-peptide orexin OX 1 receptor antagonist (K d =5.03 nM), exhibits 100-fold selectivity for OX 1 over OX 2 receptors with IC 50 values of 3.76 nM and 531 nM, respectively [1] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 483313-22-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10898. | |
| SB-699551 | SB-699551 is a potent and selective 5-HT5A antagonist with a K i value of 5.1 μM. SB-699551 increases the phosphorylation levels of CREB and ATF1 , and decreases the phosphorylation levels of AKT , PRAS40 , P70S6K , FOXO1 , and S6RP. SB-699551 improves drug-induced cognitive deficits. SB-699551 improves social withdrawal and forgetfulness. SB-699551 inhibits breast cancer. Uses: Scientific research. Group: Signaling pathways. CAS No. 864741-95-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-103100. | |
| SB-743921 hydrochloride | SB-743921 hydrochloride is a potent inhibitor of the mitotic kinesin KSP (Eg5) , with a K i of 0.1 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 940929-33-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12069. | |
| SB-747651A dihydrochloride | SB-747651A dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC50 of 11 nM. SB-747651A dihydrochloride also inhibits PRK2, RSK1, p70S6K and ROCK-II. SB-747651A dihydrochloride can be used for inflammation research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1781882-72-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110313. | |
| SB-772077B dihydrochloride | SB-772077B dihydrochloride is an aminofurazan-based Rho kinase (ROCK) inhibitor with IC50s of 5.6 nM and 6 nM toward ROCK1 and ROCK2, respevtively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 607373-46-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108518. | |
| sBADA | sBADA is a potent green fluorescent dye. sBADA is a sulfonated BODIPY-FL 3-amino-D-alanine. sBADA is used to label peptidoglycans in bacterial cell walls in situ. (λ ex =490 nm, λ em =510 nm) [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 2376838-11-6. Pack Sizes: 1 mg. Product ID: HY-D1690A. | |
| (S)-BAY 73-6691 | (S)-BAY 73-6691 is the isomer of BAY 73-6691 (HY-104028), and can be used as an experimental control. BAY 73-6691 ((R)-BAY 73-6691) is a potent, brain penetrant, and selective PDE9A inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 794568-91-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104028B. | |
| (S)-(-)-Bay-K-8644 | (S)-(-)-Bay-K-8644 is an agonist of L-type Ca 2+ channel. (S)-(-)-Bay-K-8644 activates Ba 2+ currents ( I Ba ) ( EC 50 =32 nM). Uses: Scientific research. Group: Signaling pathways. CAS No. 98625-26-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-15124. | |
| SBFI-AM | SBFI-AM is a Na + selective fluorescent indicator. SBFI-AM shows selectivity for Na + over K + [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 129423-53-6. Pack Sizes: 281 μg (5 mM * 50 μL in DMSO). Product ID: HY-126831. | |
| SBI-0206965 | SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50s of 108 nM for ULK1 kinase and 711 nM for the highly related kinase ULK2. SBI-0206965 is also an AMPK inhibitor that can paradoxically increase Thr172 phosphorylation[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1884220-36-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16966. | |
| SBI-0640756 | SBI-0640756 (SBI-756) is an inhibitor of eIF4G1 and disrupts the eIF4F complex. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SBI-756. CAS No. 1821280-29-8. Pack Sizes: 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19560. | |
| SBI-115 | SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 882366-16-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111534. | |
| SBI-425 | SBI-425 is an orally active and potent TNAP (tissue-nonspecific alkaline phosphatase) inhibitor (IC50=16 nM). SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1451272-71-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124756. | |
| SBI-553 | SBI-553 is a potent and brain penetrant NTR1 allosteric modulator, with an EC50 of 0.34 ?M[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1849603-72-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125880. | |
| SBI-581 | SBI-581 is an orally active and potent selective serine-threonine kinase TAO3 inhibitor, with an IC50 of 42 nM. SBI-581 promotes TKS5? accumulation at RAB11-positive vesicles. SBI-581 inhibits invadopodia formation. SBI-581 shows reasonable pharmacokinetics in mice using IP injection. SBI-581 shows antitumor activity[1]. SBI-581 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139439. | |
| SBI-797812 | SBI-797812 is an orally active nicotinamide phosphoribosyltransferase (NAMPT) activator. SBI-797812 shifts NAMPT to NMN formation, increases NAMPT affinity for ATP, stabilizes phosphorylated NAMPT, promotes consumption of the pyrophosphate by-product, and blunts feedback inhibition by NAD+. SBI-797812 increases intracellular nicotinamide mononucleotide (NMN) and elevates liver NAD+ in mice[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2237268-08-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126255. | |
| SBP-3264 | SBP-3264 is a valuable chemical probe for understanding the roles of STK3 and STK4 in acute myeloid leukemia (AML). Uses: Scientific research. Group: Signaling pathways. CAS No. 2869148-13-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132969. | |
| SBP-7455 | SBP-7455 is a potent, high affinity and orally active dual ULK1/ULK2 autophagy inhibitor with IC50s of 13 nM and 476 nM in the ADP-Glo assays, respectively. SBP-7455 potently inhibits ULK1/2 enzymatic activity and can be used for triple-negative breast cancer (TNBC) research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1884222-74-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137742. | |
| SC-10 | SC-10 is a direct activator of PKC [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 102649-79-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100931. | |
| SC144 | SC144 is a first-in-class, orally active gp130 (IL6-beta) inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 shows potent inhibition of gp130 ligand-triggered signaling. SC144 induces apoptosis in human ovarian cancer cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 895158-95-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15614. | |
| SC144 hydrochloride | SC144 hydrochloride is a first-in-class, orally active gp130 (IL6-beta) inhibitor. SC144 hydrochloride binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 hydrochloride shows potent inhibition of gp130 ligand-triggered signaling. SC144 hydrochloride induces apoptosis in human ovarian cancer cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 917497-70-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15614A. | |
| SC-2001 | SC-2001 is a compound structurally related to obatoclax that has better antitumor effects than obatoclax in liver cancer cell lines, downregulating Mcl-1 protein levels, inhibiting STAT3 phosphorylation, inducing apoptosis, and enhancing SHP1 expression and activity. Uses: Scientific research. Group: Signaling pathways. CAS No. 1383727-17-0. Pack Sizes: 1 mg. Product ID: HY-120113. | |
| SC209 | SC209, an ADC cytotoxin extracted from patent WO2021247798, is used in synthesis of anti- EGFR antibody-drug conjugate ADC. SC209 is the payload of STRO-002 [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1977557-86-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144880. | |
| SC-26196 | SC-26196 is a potent, orally active Delta6 desaturase (D6D, FADS2) inhibitor (IC50=0.2 ?M in a rat liver microsomal assay). Antiinflammatory properties[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 218136-59-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-107410. | |
| SC-43 | SC-43, a Sorafenib derivative, is a potent and orally active SHP-1 (PTPN6) agonist. SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis. SC-43 has anti-fibrotic and anticancer effects[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1400989-25-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-136657. | |
| SC 51089 free base | SC 51089 free base is a selective antagonist of prostaglandin E 2 EP1 receptor , with K i s of 1.3, 11.2, 17.5, and 61.1 μM for EP1 , TP , EP3 , and FP receptors , respectively. SC 51089 free base exhibits neuroprotective activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 146033-03-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108563A. | |
| SC-514 | SC-514 is a selective IKK-2 inhibitor ( IC 50 =11.2 μM), which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GK 01140. CAS No. 354812-17-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13802. | |
| SC-560 | SC-560 is a potent and selective COX-1 inhibitor with an IC 50 of 9 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 188817-13-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-59105. | |
| SC-58125 | SC-58125 is a potent and selective inhibitor of cyclooxygenase 2 (COX-2) , with an IC 50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo. SC-58125 also can inhibit edema at the inflammatory site and has analgesic effect [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 162054-19-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W013164. | |
| SC75741 | SC75741 is a broad and efficient NF-?B inhibitor with an IC50 of 200 nM for p65[1]. SC75741 blocks influenza viruses (IV) replication. SC75741 impairs DNA binding of the NF-?B subunit p65, resulting in reduced expression of cytokines, chemokines, and pro-apoptotic factors. SC75741 subsequently inhibits caspase activation and blocks caspase-mediated nuclear export of viral ribonucleoproteins[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 913822-46-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10496. | |
| SC79 | SC79, a unique specific and BBB permeable Akt activator, activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 305834-79-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-18749. | |
| (S)-Carvedilol | (S)-Carvedilol, the S-enantiomer of Carvedilol, is a non-selective ?/?-1 blocker. (S)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX)[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (S)-BM 14190. CAS No. 95094-00-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0006B. | |
| (S)-(+)-Carvone | (S)-(+)-Carvone is an orally active natural product. (S)-(+)-Carvone increases the activity of antioxidant enzymes ( SOD , CAT ) and ROS , reduces the levels of oxidative stress markers ( MDA , AChE ), reduces the secretion of proinflammatory cytokines ( IL-1β , IL-4 , IL-6 , IL-10 ), and downregulates NLRP3. (S)-(+)-Carvone increases the activities of caspase -8, -9 and -3. (S)-(+)-Carvone induces apoptotic death. (S)-(+)-Carvone has antimanic-like effect, liver protection and anticancer activity against skin cancer. (S)-(+)-Carvone improves memory and arthritis [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12]. Uses: Scientific research. Group: Natural products. Alternative Names: D-Carvone. CAS No. 2244-16-8. Pack Sizes: 500 mg; 1 g. Product ID: HY-W013579. | |
| SCH-202676 hydrobromide | SCH-202676 hydrobromide is an allosteric modulator of G protein-coupled receptors ( GPCRs ) and adenosine receptor ( AR ). SCH-202676 hydrobromide has antiviral activity and inhibits 3CL pro in a time-dependent manner with an IC 50 value of 0.655 μM [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 265980-25-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110012. | |
| SCH 221510 | SCH 221510 is a potent, orally active and selective NOP (nociceptin opioid receptor) agonist, with an EC 50 of 12 nM and K i of 0.3 nM. SCH 221510 shows an anxiolytic-like effect [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 322473-89-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107722. | |
| SCH-23390 hydrochloride | SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D 1 -like receptor antagonist with K i s of 0.2 nM and 0.3 nM for the D 1 and D 5 receptor , respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT 2C receptor agonist with a K i of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT 2 and 5-HT 1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC 50 of 268 nM [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R-(+)-SCH-23390 hydrochloride. CAS No. 125941-87-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19545A. | |
| SCH 50911 | SCH 50911, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, binds to GABA(B) receptor with IC 50 of 1.1 μM. SCH 50911 antagonizes GABA(B) autoreceptors, increasing the electrically-stimulated 3 H overflow with an IC 50 of 3 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 733717-87-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12783A. | |
| SCH529074 | SCH529074 is a potent and orally active p53 activator. SCH529074 binds specifically and conformation-dependently to p53 DBD ( DNA binding domain) with a Ki of 1-2 ?M in a saturable manner. SCH529074 restores mutant p53 function and interrupts HDM2-mediated ubiquitination of wild Type p53. SCH529074 can be used for the study of non-small-cell lung carcinoma (NSCLC)[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 922150-11-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110088. | |
| SCH 546738 | SCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments. Uses: Scientific research. Group: Signaling pathways. CAS No. 906805-42-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10017. | |
| SCH 58261 | SCH 58261 is a potent, selective and competitive antagonist of adenosine A2A receptor with an IC 50 of 15 nM, and displays 323-, 53- and 100-fold more selective for A2A receptor than A1, A2B, and A3 receptors, respectively [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 160098-96-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19533. | |
| SCH772984 | SCH772984 is a highly selective and ATP-competitive ERK inhibitor, with IC50s of 4 and 1 nM for ERK1 and ERK2, respectively. SCH772984 has antitumor activity in MAPK inhibitor-na?ve and MAPK inhibitor-resistant cells containing BRAF or RAS mutations[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 942183-80-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-50846. | |
| SCH79797 | SCH79797 is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC 50 of 70 nM and a K i of 35 nM. SCH79797 inhibits thrombin-induced platelet aggregation with an IC 50 of 3 μM. SCH79797 has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 245520-69-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14993. | |
| SCH79797 dihydrochloride | SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 dihydrochloride inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC 50 of 70 nM and a K i of 35 nM. SCH79797 dihydrochloride inhibits thrombin-induced platelet aggregation with an IC 50 of 3 μM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 dihydrochloride also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1216720-69-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14994. | |
| SCH-900271 | SCH-900271 is an orally active, potent nicotinic acid receptor (NAR) agonist with an EC 50 of 2 nM in the hu-GPR109a assay. SCH-900271 exhibits dose-dependent inhibition of plasma free fatty acid (FFA). SCH-900271 has an improved therapeutic window to flushing [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 915210-50-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-111143. | |
| SCH900776 | SCH900776 (MK-8776) is a potent, selective and orally bioavailable inhibitor of checkpoint kinase1 (Chk1) with an IC50 of 3 nM. SCH900776 shows 50- and 500-fold selectivity over CDK2 and Chk2, respectively[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-8776. CAS No. 891494-63-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15532. | |
| Schisandrin | Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Schizandrin; Schizandrol; Schizandrol-A. CAS No. 7432-28-2. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0691. | |
| Schisandrin A | Schisandrin A inhibits CYP3A activity with an IC 50 of 6.60 μM and K i of 5.83 μM, respectively. Uses: Scientific research. Group: Natural products. Alternative Names: Schizandrin-A; Wuweizisu-A; Deoxyschizandrin. CAS No. 61281-38-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0693. | |
| (+)-Schisandrin B | (+)-Schisandrin B is an enantiomer of Schisandrin B. Schisandrin B is an active dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chinensis , has antioxidant effect on rodent liver and heart [1]. Uses: Scientific research. Group: Natural products. CAS No. 82467-52-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N2267. | |
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