MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Baricitinib | Baricitinib (LY3009104; INCB028050) is a selective and orally bioavailable JAK1 and JAK2 inhibitor with IC 50 s of 5.9 nM and 5.7 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY3009104; INCB028050. CAS No. 1187594-09-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-15315. |  |
| Baricitinib phosphate | Baricitinib phosphate (LY3009104 phosphate; INCB028050 phosphate) is a selective orally bioavailable JAK1 / JAK2 inhibitor with IC 50 of 5.9 nM and 5.7 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY3009104 phosphate; INCB028050 phosphate. CAS No. 1187595-84-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15315A. | |
| Barium diphenylamine-4-sulfonate | Barium diphenylamine-4-sulfonate can be employed as an intermediate in pharmaceutical manufacturing and in chemical research, and serves as a dosing agent in analytical testing [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 6211-24-1. Pack Sizes: 1 g; 5 g. Product ID: HY-W087892. | |
| Barnidipine hydrochloride | Barnidipine (Mepirodipine) hydrochloride is an L-type calcium antagonist ( CaA ) with high affinity for [ 3 H] initrendipine binding sites ( K i = 0.21 nmol/L, has selective action against CaA receptors. Barnidipine hydrochloride is an orally active antihypertensive agent that can reduce the level of platelet-derived growth factor B-chain mRNA and peripheral vascular resistance [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Mepirodipine hydrochloride; YM-09730-5. CAS No. 104757-53-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-107322. | |
| Barzolvolimab | Barzolvolimab (CDX 0159) is a humanized anti- KIT IgG1 monoclonal antibody. Barzolvolimab specificity and potently inhibits KIT activation by SCF. Barzolvolimab can reduce skin mast cells and disease activity in chronic inducible urticaria [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: CDX-0159; CDX-0158. CAS No. 2438203-51-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99462. | |
| Basiliximab | Basiliximab (CHI 621) is a recombinant chimeric murine/human IgG1 monoclonal anti- interleukin-2 receptor antibody. Basiliximab can be used for the research of renal transplantation [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: CHI 621. CAS No. 179045-86-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-108852. | |
| Basimglurant | Basimglurant (RG7090) is a potent, selective and orally available mGlu5 negative allosteric modulator with a K d of 1.1 nM [1]. Basimglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RG7090; CTEP Derivative. CAS No. 802906-73-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15446. | |
| Basmisanil | Basmisanil (RG1662) is a highly selective orally active α subunit-containing GABAA receptors (GABAAα5) negative allosteric modulator (NAMs). Basmisanil can inhibit GABAA-α5 with a K i value of 5 nM and IC 50 value of 8 nM, respectively. Basmisanil can be used for the research of multiple cognitive and psychiatric disorders [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RG1662; RO5186582. CAS No. 1159600-41-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16716. | |
| Basroparib | Basroparib (STP1002) is a selective, orally active inhibitor of tankyrase (TNKS1/TNKS2) with IC50 of 29.94 nM and 3.68 nM for TNKS1 and TNKS2, respectively. Basroparib has an IC50 of >10 ?M for PARP1. Basroparib binds to TNKS, stabilizes AXIN1/2 proteins, blocks Wnt/?-catenin signaling pathway, inhibits tumor cell proliferation and induces apoptosis, while reducing cancer stem cell properties. Basroparib can be used in colorectal cancer (CRC) studies with KRAS mutations (such as G12V/G12D) to overcome acquired resistance to MEK inhibitors. STP1002 has synergistic antitumor activity with MEK inhibitors[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: STP1002. CAS No. 1858179-75-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147245. | |
| Batabulin | Batabulin (T138067) is an antitumor agent, which binds covalently and selectively to a subset of the β-tubulin isotypes , thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to cell-cycle arrest ultimately induces apoptotic cell death [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: T138067. CAS No. 195533-53-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13563. | |
| Batabulin sodium | Batabulin sodium (T138067 sodium) is an antitumor agent, which binds covalently and selectively to a subset of the β-tubulin isotypes , thereby disrupting microtubule polymerization. Batabulin sodium affects cell morphology and leads to cell-cycle arrest ultimately induces apoptotic cell death [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: T138067 sodium. CAS No. 195533-98-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13563A. | |
| Bathocuproine disulfonate disodium | Bathocuproine disulfonate disodium (BCS) is an organic compound used as a highly sensitive colorimetric reagent for copper ions in biochemical and analytical applications. It has a bright yellow color and absorbs light at specific wavelengths, so it can be used to detect and quantify trace copper. In biochemical applications, BCS is commonly used to study the role of copper ions in various biological processes. Copper is an essential nutrient for many organisms, but it can also be toxic in high concentrations, so accurate measurement of copper levels is important to understand its impact on living systems. In terms of analysis, BCS is often used in environmental monitoring and water quality testing to detect copper pollution. It can detect copper even at very low concentrations, making it an invaluable tool for identifying potential sources of pollution and assessing the impact of industrial activities on aquatic ecosystems. Uses: Scientific research. Group: Fluorescent dye. CAS No. 52698-84-7. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W034953. | |
| Bathophenanthrolinedisulfonic acid disodium | Bathophenanthrolinedisulfonic acid disodium salt (BPS) is a colorimetric reagent for iron detection, with a wavelength of 535 nm for iron complex. It can be used for iron determination in aqueous solution systems without the need for extraction solvents. BPS can serve as a precursor to prepare Europium(III) tris(dibenzoylmethanate) bis(bathophenanthrolinedisulfonate) complex and ruthenium(II) tris (bathophenanthrolinedisulfonate), or participate in the catalytic oxidation of 2-hexanol by forming water-soluble complexes with palladium [1] [2] [3]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 52746-49-3. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-W127790. | |
| Batilol | 3-(Octadecyloxy)propane-1,2-diol is an endogenous metabolite. Uses: Scientific research. Group: Natural products. CAS No. 544-62-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 1 g. Product ID: HY-W011175. | |
| Batimastat | Batimastat is a potent broad spectrum MMP inhibitor with IC 50 of 3, 4, 4, 6, and 20 nM for MMP-1 , MMP-2 , MMP-9 , MMP-7 and MMP-3 , respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BB94. CAS No. 130370-60-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13564. | |
| Batoclimab | Batoclimab is a human anti- FcRn monoclonal antibody. Batoclimab can be used for the research of autoimmune diseases mediated by pathogenic IgG antibodies [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: HBM9161; IMVT-1401. CAS No. 2187430-05-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99009. | |
| Batoprotafib | Batoprotafib (TNO155) is a potent selective and orally active allosteric inhibitor of wild-type SHP2 ( IC 50 =0.011 μM). Batoprotafib has the potential for the study of RTK-dependent malignancies, especially advanced solid tumors [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TNO155. CAS No. 1801765-04-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136173. | |
| Bavachinin | Bavachinin is agonist of pan-peroxisome proliferator-activated receptor (PPAR), with the IC50 value of 21.043 ?M, 12.819 ?M, and 0.622 ?M to PPAR-?, RRAR-?/?, and PPAR-?, respectively. Bavachinin is an inhibitor of HIF-1?. Bavachinin exhibits antitumor activity against non-small cell lung cancer by targeting RRAR-?. Bavachinin is a natural compound with anti-inflammatory and anti-angiogenic activities. Bavachinin has orally bioactivity.[1][2][3][4][5]. Uses: Scientific research. Group: Natural products. Alternative Names: 7-O-Methylbavachin; Bavachinin A. CAS No. 19879-30-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-N0234. | |
| Bavdegalutamide | Bavdegalutamide (ARV-110) is an orally active, specific androgen receptor (AR) PROTAC degrader. Bavdegalutamide promotes ubiquitination and degradation of AR. Bavdegalutamide can be used for the research of prostate cancer (Pink: AR ligand (HY-168299); Blue: E3 ligase ligand (HY-W093272); Black: linker (HY-W091986))[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ARV-110. CAS No. 2222112-77-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138641. | |
| Bavisant | Bavisant (JNJ-31001074) is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H 3 receptor. Bavisant can be used for attention-deficit hyperactivity disorder (ADHD) research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: JNJ-31001074. CAS No. 929622-08-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-14880. | |
| Bavisant dihydrochloride hydrate | Bavisant dihydrochloride hydrate (JNJ31001074AAC) is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H 3 receptor. Bavisant dihydrochloride hydrate can be used for attention-deficit hyperactivity disorder (ADHD) research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: JNJ31001074AAC; JNJ31001074 dihydrochloride hydrate. CAS No. 1103522-80-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-14880B. | |
| Bavituximab | Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) is a phosphatidylserine (PS)-targeting monoclonal antibody, suppresses tumor growth by targeting tumor vasculature and reactivating antitumor immunity. Bavituximab plus Paclitaxel (HY-B0015) and Carboplatin (HY-17393), have enhanced inhibition on non-small-cell lung cancer [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Anti-Human Phosphatidylserine Recombinant Antibody. CAS No. 648904-28-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99279. | |
| Baxdrostat | Baxdrostat is a aldosterone synthase inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CIN-107. CAS No. 1428652-17-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132809. | |
| BAY-069 | BAY-069 is a potent branched-chain amino acid transaminases 1 (BCAT1) and BCAT2 inhibitor with IC50 values of 31 nM and 153 nM, respectively. BAY-069 also can be used as a chemical probe. BAY-069 can be used tor research anticancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2639638-66-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148242. | |
| BAY1125976 | BAY1125976 is a selective allosteric Akt1/Akt2 inhibitor; inhibits Akt1 and Akt2 activity with IC50 values of 5.2 nM and 18 nM at 10 ?M ATP, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1402608-02-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-100018. | |
| BAY 11-7082 | BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 ( IC 50 =0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 11-7821. CAS No. 19542-67-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13453. | |
| BAY 11-7085 | BAY 11-7085 (BAY 11-7083) is an inhibitor of NF-?B activation and phosphorylation of I?B?; it stabilizes I?B? with an IC50 of 10 ?M[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 11-7083. CAS No. 196309-76-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10257. | |
| BAY 1214784 | BAY 1214784 is a potent, selective, and orally active antagonist of the human gonadotropin-releasing hormone receptor ( hGnRH-R ). BAY 1214784 is a spiroindoline derivative compound. BAY 1214784 effectively lowers plasma luteinizing hormone levels by up to 49%, at the same time being associated with low pharmacokinetic variability and good tolerability. BAY 1214784 has the potential for the research of uterine fibroids [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1631164-25-4. Pack Sizes: 5 mg. Product ID: HY-144863. | |
| BAY1217389 | BAY 1217389 is a potent, and selective inhibitor of the monopolar spindle 1 (MPS1) kinase with an IC50 value less than 10 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1554458-53-5. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12859. | |
| BAY-179 | BAY-179 is a potent, selective, and species cross-reactive complex I inhibitor. BAY-179 shows IC50 values of 79 nM, 38 nM, 27 nM, and 47 nM for human, mouse, rat, and dog complex I, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2764880-87-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145707. | |
| BAY-1797 | BAY-1797 is a potent, orally active, and selective P2X4 antagonist, with an IC50 of 211 nM against human P2X4. BAY-1797 displays no or very weak activity on the other P2X ion channels. BAY-1797 shows anti-nociceptive and anti-inflammatory effects[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2055602-83-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130605. | |
| BAY-1816032 | BAY-1816032 is a potent and oral available BUB1 (budding uninhibited by benzimidazoles 1) kinase inhibitor with an IC50 of 7 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1891087-61-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103020. | |
| BAY-204 | BAY-204 is an inhibitor of Casein kinase 1 alpha and delta (CSNK1? and ?) useful for the research of proliferative disorders. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BRD3727. CAS No. 2468784-57-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-145940. | |
| BAY-218 | BAY-218 (AHR antagonist 1) is an aryl hydrocarbon receptor (AHR) antagonist. BAY-218 has AHR inhibitory activity with an IC 50 of 39.9 nM in in U87 glioblastoma cells. BAY-218 can be used for the research of cancer or conditions with dysregulated immune responses [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AHR antagonist 1. CAS No. 2162982-11-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111449. | |
| BAY-2402234 | BAY-2402234 is a selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies. Uses: Scientific research. Group: Signaling pathways. CAS No. 2225819-06-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112645. | |
| BAY 2416964 | BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC 50 of 341 nM. BAY 2416964 has the potential for solid tumors treatment [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2242464-44-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135829. | |
| BAY-293 | BAY-293, a valuable chemical probe, blocks RAS activation via disruption of the KRAS-SOS1 interaction with an IC50 of 21 nM. BAY-293 is a potent inhibitor of Son of Sevenless 1 (SOS1). SOS1 is the guanine nucleotide exchange factor (GEF) and activator of RAS[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2244904-70-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114398. | |
| BAY 2965501 | BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGK?) inhibitor. BAY 2965501 induces pERK activation. BAY 2965501 can be used for the research of cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2732902-08-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153343. | |
| BAY-299 | BAY-299 is a very potent, dual inhibitor with IC50s of 67 nM for BRPF2 bromodomains (BD), 8 nM for TAF1 BD2, and 106 nM for TAF1L BD2. Uses: Scientific research. Group: Signaling pathways. CAS No. 2080306-23-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107424. | |
| BAY32-5915 | BAY32-5915 is a potent IKK? inhibitor with an IC50 value of 60 nM. BAY32-5915 has not affect Doxorubicin (HY-15142A)-induced NF-?B activation[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1571-30-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-W067427. | |
| BAY-3827 | BAY-3827 is a potent and selective AMPK inhibitor with IC50 values of 1.4 nM at low (10 ?M ATP concentration) and 15 nM at high (2 mM ATP concentration). BAY-3827 shows over 500-fold selectivity for most of the 331 kinases. BAY-3827 prevents phosphorylation of acetyl-CoA carboxylase 1 and shows strongest anti-proliferative activity in androgen-dependent prostate cancer cell lines[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2377576-35-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112083. | |
| BAY 41-2272 | BAY 41-2272 is an orally active and soluble guanylate cyclases ( sGC ) activator, which increases sGC activity by 400-fold in synergy with NO. BAY 41-2272 potently unloaded the heart, increased cardiac output, thus can be used for cardiovascular diseases research [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 256376-24-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12376. | |
| BAY-549 | BAY-549 (Azaindole 1) is an orally active and ATP-competitive ROCK inhibitor with IC 50 s of 0.6 and 1.1?nM for human ROCK-1 and ROCK-2 , respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ROCK-IN-2; Azaindole 1; TC-S 7001. CAS No. 867017-68-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10319. | |
| BAY-5516 | BAY-5516 is a inverse-agonist o PPAR G, with the IC 50 value of 6.1±3.6 nM that has anti-tumor effect [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2891706-79-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-160160. | |
| BAY 59-9435 | BAY 59-9435 is a potent and selective inhibitor of Hormone Sensitive Lipase (HSL), with an IC50 of 0.023 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 654059-21-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102056. | |
| BAY 60-2770 | BAY 60-2770 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1027642-43-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113926. | |
| BAY-6035 | BAY-6035 is a potent, selective and substrate-competitive inhibitor of SMYD3. BAY-6035 inhibits methylation of MEKK2 peptide with an IC 50 of 88 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2247890-13-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112080. | |
| BAY 60-6583 | BAY 60-6583 is a potent and high-affinity agonist of adenosine A 2B receptor ( EC 50 = 3 nM) over A1, A2A, and A3 receptors. BAY 60-6583 binds to mouse, rabbit, and dog A2BAR with K i values of 750 nM, 340 nM and 330 nM, respectively. BAY 60-6583 has a cardioprotective effect in a myocardial ischemia model [1] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 910487-58-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103171. | |
| Bay 60-7550 | Bay 60-7550 is a potent and selective PDE2 inhibitor with a Ki of 3.8 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 607550. CAS No. 439083-90-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14992. | |
| BAY-707 | BAY-707 is a substrate-competitive, highly potent and selective inhibitor of MTH1(NUDT1) with an IC 50 of 2.3 nM. BAY-707 has a good pharmacokinetic (PK) profile to other MTH1 compounds and is well-tolerated in mice, but shows a clear lack of in vitro or in vivo anticancer efficacy [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2109805-96-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112081. | |
| BAY-8002 | BAY-8002 is a potent, selective, orally active inhibitor of monocarboxylate transporter 1 (MCT1), with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4. Anti-tumor activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 724440-27-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-122312. | |
| BAY-805 | BAY-805 is a selective inhibitor of ubiquitin-specific protease USP21. BAY-805 has high selectivity for deubiquitinating enzyme (DUB) targets, kinases, proteases and other common target enzymes[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2925481-88-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153045. | |
| BAY-826 | BAY-826 is a selective and potent TIE-2 inhibitor with a Kd of 1.6 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1448316-08-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100756. | |
| BAY-850 | BAY-850 is a potent and isoform selective ATPase family AAA domain-containing protein 2 (ATAD2) inhibitor, with an IC50 of 166 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 2099142-76-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119254. | |
| BAY-85-8501 | BAY-85-8501 is a selective, reversible and potent inhibitor of Human Neutrophil Elastase (HNE), with an IC50 of 65 pM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1161921-82-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19908. | |
| BAY 87-2243 | BAY 87-2243 is a highly potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 1227158-85-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15836. | |
| BAY-876 | BAY-876 is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC 50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth. In addition, BAY-876 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1799753-84-6. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100017. | |
| BAY-985 | BAY-985 is a highly potent, orally active and selective ATP-competitive dual inhibitor of TBK1 and IKK? with IC50s of 2/30 and 2 nM for TBK1 (low/high ATP) and IKK?, respectively. Antitumor efficacy[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2409479-29-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133117. | |
| Bay K 8644 | Bay K 8644 ((±)-Bay K 8644) is a racemate consisting of two isomers (R)-(+)-Bay-K-8644 and (S)-(-)-Bay-K-8644 [1]. Bay K 8644 is a L-type Ca 2+ channel agonist with an EC 50 of 17.3 nM. Bay K 8644 increases Ca 2+ influx through sarcolemmal Ca 2+ channels by increasing the open time of the channel. Bay K 8644 has vasoconstrictive effects [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (±)-Bay K 8644. CAS No. 71145-03-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10588. | |
| BAZ2-ICR | BAZ2-ICR is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC50s of 130 nM and 180 nM, and Kds of 109 nM and 170 nM, respectively. BAZ2-ICR shows 10-15-fold selectivity for binding BAZ2A/B over CECR2 and >100-fold selectivity over all other bromodomains. BAZ2-ICR is an epigenetic chemical probe[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1665195-94-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 2 g. Product ID: HY-19336. | |
| Bazedoxifene | Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM) , with IC 50 s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TSE-424. CAS No. 198481-32-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0031. | |
| Bazedoxifene acetate | Bazedoxifene acetate (TSE-424 acetate) is an oral, nonsteroidal selective estrogen receptor modulator (SERM) , with IC 50 s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene acetate can be used for the research of osteoporosis. Bazedoxifene acetate also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TSE-424 acetate. CAS No. 198481-33-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-A0036. | |
| Bazedoxifene (acetate)-B | Bazedoxifene (acetate)-B (TSE-424 (acetate)-B) is the B-crystal form compound of Bazedoxifene acetate (HY-A0036). Bazedoxifene acetate is an orally active, nonsteroidal selective estrogen receptor modulator (SERM), with IC 50 s of 23 nM and 99 nM for ERα and ERβ, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TSE-424 (acetate)-B. CAS No. 198481-33-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0036B. | |
| Bazedoxifene (acetate)-D | Bazedoxifene (acetate)-D (TSE-424 (acetate)-D) is the D-crystal form compound of Bazedoxifene acetate (HY-A0036). Bazedoxifene acetate is an orally active, nonsteroidal selective estrogen receptor modulator (SERM), with IC 50 s of 23 nM and 99 nM for ERα and ERβ, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TSE-424 (acetate)-D. CAS No. 198481-33-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0036D. | |
| Bazedoxifene N-Oxide | Bazedoxifene N-Oxide is the oxidative degradation product of selective estrogen receptor modulator (SERM) Bazedoxifene [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1174289-22-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-Z0833. | |
| BBC0403 | BBC0403 is a selective BRD2 inhibitor with Kds of 7.64 ?M and 41.37 ?M for BRD2 (BD2) and BRD2 (BD1), respectively. BBC0403 exhibitS higher binding specificity for BRD2 compared to BRD3 and BRD4. BBC0403 has the potential for osteoarthritis (OA) research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2644662-83-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-162514. | |
| BB-Cl-Amidine | BB-Cl-Amidine is a peptidylarginine deminase (PAD) inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 1802637-39-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111347. | |
| BB-Cl-Amidine hydrochloride | BB-Cl-Amidine hydrochloride is a peptidylarginine deminase (PAD) inhibitor[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2436747-41-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111347A. | |
| BBD | BBD (NSC240867) is a biochemical reagent/chromogenic reagent. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: NSC240867; Benzylamino-NBD. CAS No. 18378-20-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-15907. | |
| BBO-10203 | BBO-10203 (Compound 758) binds to the RBD region of PI3K?, and inhibits the binding of K-, H-, and N-Ras to PI3K?. BBO-10203 inhibits pAKT with an IC50 < 0.1 pM in BT474 cell[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2971769-60-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-159852. | |
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