MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Avatrombopag maleate | Avatrombopag maleate (AKR-501) is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist ( EC 50 =3.3 nM). Avatrombopag maleate mimics the biological activities of TPO. Avatrombopag maleate increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag maleate is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AKR-501 maleate; E5501 maleate; YM477 maleate. CAS No. 677007-74-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13463A. |  |
| Avdoralimab | Avdoralimab (IPH 5401) is a fully human IgGκ monoclonal antibody that targets the complement C5a receptor 1 (C5aR1) that prevents its binding to C5a. Avdoralimab can be used for complement-driven inflammatory diseases and solid tumours research [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: IPH 5401; Anti-C5aR1 mAb. CAS No. 2226393-85-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99450. | |
| AVE 0991 | AVE 0991 is a nonpeptide and orally active angiotensin-(1-7) receptor agonist with an IC50 of 21 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 304462-19-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15778. | |
| Avelumab | Avelumab is a fully human IgG1 anti- PD-L1 monoclonal antibody with potential antibody-dependent cell-mediated cytotoxicity. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Anti-Human PD-L1, Human Antibody; MSB 0010718C; MSB0010718C. CAS No. 1537032-82-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-108730. | |
| Avelumab (anti-PD-L1) | Avelumab (anti-PD-L1) is a fully human IgG1 anti- PD-L1 monoclonal antibody with potential antibody-dependent cell-mediated cytotoxicity [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 1537032-82-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-108730A. | |
| Avenanthramide A | Avenanthramide A is a phytoalexin, which can be found in oats ( Avena sativa L. ). Avenanthramide A targets the RNA helicase DDX3 , leads to mitochondrial swelling and increased ROS production, and induces apoptosis in CRC cells. Avenanthramide A exhibits antitumor efficacy in mouse model. Avenanthramide A orally active [1]. Uses: Scientific research. Group: Natural products. CAS No. 108605-70-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-114977. | |
| Avenanthramide C | Avenanthramide C is an orally active avenanthramide that can be isolated from oat seeds. Avenanthramide C decreases the protein expression of cleaved caspase-3 and increases the expression of p-GSK3β(Ser9) and IL-10 levels. Avenanthramide C has the potential for the research of Alzheimers disease [1]. Uses: Scientific research. Group: Natural products. CAS No. 116764-15-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-124344. | |
| Avermectin B1a | Avermectin B1a is an antiparasitic agent that paralyzes nematodes without causing hypercontraction or flaccid paralysis. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Abamectin B1a. CAS No. 65195-55-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15308. | |
| Avibactam free acid | Avibactam (NXL-104) free acid is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC 50 s of 8 nM and 5 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NXL-104 free acid. CAS No. 1192500-31-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14879. | |
| Avibactam sodium | Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC 50 s of 8 nM and 5 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NXL-104. CAS No. 1192491-61-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-14879A. | |
| Avibactam sodium hydrate | Avibactam sodium (NXL-104) hydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC 50 s of 8 nM and 5 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NXL-104 hydrate. CAS No. 2938989-90-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-14879B. | |
| Avibactam tomilopil | Avibactam tomilopil (ARX-1796, AV-006) is an orally active prodrug of Avibactam and a β-lactamase inhibitor. Avibactam tomilopil can be used in the study of diseases such as urinary tract infections [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ARX-1796; AV-006. CAS No. 2245880-46-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132987. | |
| Avicularin | Avicularin is an orally active flavonoid. Avicularin inhibits NF-κB (p65) , COX-2 and PPAR-γ activities. Avicularin has anti-inflammatory, anti-infectious anti-allergic, anti-oxidant, hepatoprotective, and anti-tumor activities [1] [3]. Uses: Scientific research. Group: Natural products. CAS No. 572-30-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0222. | |
| Avidin, chiken egg white | Avidin, chicken egg white is a glycoprotein derived from egg protein. Avidin, chicken egg white has excellent affinity with biotin and is often used in combination with biotin for immunoassays to detect the location of antigens in tissues [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 1405-69-2. Pack Sizes: 5 mg. Product ID: HY-NP005. | |
| Aviglycine hydrochloride | Aviglycine hydrochloride (ABG-3168) is an inhibitor of ethylene biosynthesis. The use of Aviglycine hydrochloride (ABG-3168) delays the natural flowering of pineapples, reduces fruit drop, and maintains fruit firmness [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABG-3168. CAS No. 55720-26-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W009861. | |
| Aviptadil | Aviptadil is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Peptides. Alternative Names: Vasoactive Intestinal Peptide (human, rat, mouse, rabbit, canine, porcine). CAS No. 40077-57-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-P0012. | |
| Aviptadil acetate | Aviptadil acetate is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil acetate induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil acetate can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Vasoactive Intestinal Peptide acetate salt (human, rat, mouse, rabbit, canine, porcine). CAS No. 1444827-29-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P0012A. | |
| Avitinib | Avitinib (Abivertinib) is a third-generation, irreversible and orally active selective EGFR inhibitor, with IC 50 values of 0.18 nM, 0.18 nM, 7.68 nM and against EGFR L858R , EGFR T790M and wild-type EGFR. Avitinib is also a BTK inhibitor that induces apoptosis and inhibits phosphorylation of BTK in mantle cell lymphoma. Avitinib shows anticancer effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Abivertinib; AC0010. CAS No. 1557267-42-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19816. | |
| Avitinib maleate | Avitinib (Abivertinib) maleate is a third-generation, irreversible and orally active selective EGFR inhibitor, with IC 50 values of 0.18 nM, 0.18 nM, 7.68 nM and against EGFR L858R , EGFR T790M and wild-type EGFR. Avitinib maleate is also a BTK inhibitor that induces apoptosis and inhibits phosphorylation of BTK in mantle cell lymphoma. Avitinib maleate shows anticancer effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Abivertinib maleate; AC0010 maleate. CAS No. 1557268-88-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19816A. | |
| Avizakimab | Avizakimab (BOS161721) is a humanized IgG1 monoclonal antibody that targets interleukin-21 [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BOS161721. CAS No. 2229685-51-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99451. | |
| AVJ16 | AVJ16 is a cancer cell migration inhibitor that targets the insulin-like growth factor 2 mRNA binding protein IGF2BP1 with a good affinity of Kd of 1.4?M. AVJ16 interferes with IGF2BP1 binding target mRNA to regulate gene expression and translation[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2775241-92-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144873. | |
| AVN-101 hydrochloride | AVN-101 hydrochloride is a potent, brain-penetrant and orally active 5-HT7 receptor antagonist ( K i of 153 pM), with slightly lesser potency toward 5-HT6 , 5-HT2A , and 5HT-2C receptors ( K i values of 2.04 nM, 1.56 ?nM, and 1.17? nM, respectively). AVN-101 hydrochloride also exhibits a rather high affinity toward histamine H1 ( K i of 0.58 nM) and adrenergic α2A , α2B , and α2C (Ki= 0.41-3.6 nM) receptors. AVN-101 hydrochloride can be studied in such diseases as general anxiety disorders, depression, schizophrenia, and multiple sclerosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1061354-48-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117046A. | |
| AVN-944 | AVN-944 (VX-944) is an orally active, potent, selective, noncompetitive and specific inhibitor of IMPDH (inosine monophosphate dehydrogenase). AVN-944 is an essential rate-limiting enzyme in de novo guanine nucleotide synthesis. AVN-944 is also an inhibitor of arenavirus RNA synthesis, and blocks arenavirus infection. AVN-944 has broad anti-cancer activities, and can be used for multiple myeloma (MM) and acute myeloid leukemia (AML) research[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VX-944. CAS No. 297730-17-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13560. | |
| Avobenzone | Avobenzone, a dibenzoylmethane compound, is one of the most widely used filters in sunscreens for skin photoprotection in the UVA band. Avobenzone is an endocrine disruptor that directly binds to estrogen receptor β and acts as an estrogen agonist [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 70356-09-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0316. | |
| Avoralstat | Avoralstat (BCX4161), a potent and orally active plasma kallikrein (PKK) inhibitor, is used for hereditary angioedema research[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BCX4161. CAS No. 918407-35-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16735. | |
| Avotaciclib | Avotaciclib (BEY1107) is an orally active cyclin-dependent kinase 1 (CDK1) inhibitor. Avotaciclib can inhibit the proliferation and induce apoptosis of tumor cells. Avotaciclib can be used in the research of cancer such as pancreatic cancer and lung cancer[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BEY1107. CAS No. 1983983-41-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137432. | |
| Avutometinib | Avutometinib (Ro 5126766) is a first-in-class dual MEK / RAF inhibitor that allosterically inhibits BRAF V600E , CRAF , MEK , and BRAF (IC 50 : 8.2, 56, 160 nM, and 190 nM, respectively). Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ro 5126766; CH5126766. CAS No. 946128-88-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18652. | |
| AWL-II-38.3 | AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf[1][2][1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1135205-94-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18832. | |
| AX-024 | AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 modulates cell signaling by targeting SH3 domains. AX-024 has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-?, IFN-?, IL-10 and IL-17A. Uses: Scientific research. Group: Signaling pathways. CAS No. 1370544-73-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107390. | |
| AX-15836 | AX-15836 is a potent and selective ERK5 inhibitor with an IC50 of 8 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 2035509-96-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101846. | |
| Axatilimab | Axatilimab (SNDX-6352) is a humanized IgG4 antibody with high affinity to CSF-1R. Axatilimab can be used for the research of chronic graft versus host disease (cGVHD) and neoplastic diseases [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: SNDX-6352. CAS No. 2155851-88-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99452. | |
| Axitinib | Axitinib is a multi-targeted tyrosine kinase inhibitor with IC 50 s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1 , VEGFR2 , VEGFR3 and PDGFRβ , respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AG-013736. CAS No. 319460-85-0. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10065. | |
| AXKO-0046 | AXKO-0046, indole derivative, is an uncompetitive Lactate dehydrogenase B (LDHB) selective inhibitor.AXKO-0046 has LDHB inhibitory activity with an EC50 value of 42 nM.AXKO-0046 can be used for the research of cancer metabolism[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-147216. | |
| AY 9944 | AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol ?7-reductase (DHCR7) enzyme with an IC50 of 13 nM. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol ?7-?8 isomerase, which causes the accumulation of cholest-8-en-3?-ol[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 366-93-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107420. | |
| AZ10606120 dihydrochloride | AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC 50 of about 10?nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 607378-18-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-108669. | |
| AZ-1355 | AZ-1355 is an effctive lipid-lowering compound, which also inhibits platelet aggregation in vivo and elevates the prostaglandin I 2 /thromboxane A 2 ratio in vitro. Uses: Scientific research. Group: Signaling pathways. CAS No. 75451-07-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101692. | |
| AZ13824374 | AZ13824374 is a potent and selective ATAD2 bromodomain inhibitor (pIC50 of 6.9 in HCT116 cells). AZ13824374 disrupts chromatin interactions and gene transcription by binding to the acetyl-lysine binding site of the ATAD2 bromodomain. AZ13824374 has anticancer activity against breast cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3040082-19-4. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-136521. | |
| AZ14170133 | AZ14170133 (SG 3932) is a Drug-Linker Conjugates for ADC, which comprises a topoisomerase inhibitor and a linker for ligand unit connecting. AZ14170133 can be used to synthesis antibody-drug conjugate (ADC)[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SG 3932; AZ-0133. CAS No. 2495742-34-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145399. | |
| AZ1495 | AZ1495, a weak base, is a potent orally active interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor. AZ1495 has a favorable physicochemical and kinase selectivity for IRAK4 and IRAK1 with IC50 values of 0.005 ?M and 0.023 ?M, respectively. AZ1495 has IRAK4 inhibition with a Kd value of 0.0007 ?M. AZ1495 can be used for the research of diffuse large B-cell lymphoma (DLBCL)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2196204-23-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111101. | |
| AZ191 | AZ191 is a potent inhibitor that selectively inhibits DYRK1B with IC50 of 17 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1594092-37-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12277. | |
| AZ20 | AZ20 is a potent and selective inhibitor of ATR with an IC 50 of 5 nM, and has 8-fold selectivity against mTOR (IC 50 =38 nM). Uses: Scientific research. Group: Signaling pathways. CAS No. 1233339-22-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15557. | |
| AZ304 | AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC 50 s of 79 nM, 38 nM and 68 nM, respectively. AZ304 also has significant effect on other kinases, such as p38 ( IC 50 , 6 nM), CSF1R ( IC 50 , 35 nM). Anti-tumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 942507-42-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117273. | |
| AZ31 | AZ31 is a a potent, highly selective, and orally active ATM inhibitor with an IC 50 of <1.2 nM for ATM enzyme, and an IC 50 of 46 nM for ATM in cell. AZ31 shows excellent selectivity over ATR (>500-fold) and excellent PIKK-family selectivity and pan-kinase selectivity. AZ31 is a potent radiosensitizer in vitro, it can be used for the research of cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2088113-98-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-112198. | |
| AZ3146 | AZ3146 is a reasonably potent Mps1 and TTK inhibitor, with IC50 of 35 nM for Mps1Cat. Uses: Scientific research. Group: Signaling pathways. CAS No. 1124329-14-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14710. | |
| AZ3451 | AZ3451 is a potent protease-activated receptor-2 (PAR2) antagonist with IC50 of 23 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 2100284-59-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112558. | |
| AZ505 ditrifluoroacetate | AZ505 ditrifluoroacetate is a potent and selective SMYD2 inhibitor with IC 50 of 0.12 μM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1035227-44-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15226A. | |
| AZ5576 | AZ5576 is a potent and highly selective CDK9 inhibitor (IC50: <5 nM). AZ5576 inhibits the phosphorylation of RNA polymerase II at Ser2, thereby inhibiting transcriptional elongation. AZ5576 can be used for hematological Malignancy research[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2751721-40-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-143584. | |
| AZ 628 | AZ 628 is a pan-Raf kinase inhibitor with IC 50 s of 105, 34 and 29 nM for B-Raf , B-RafV600E , and c-Raf-1 , respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 878739-06-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-11004. | |
| AZ683 | AZ683 is a potent and selective 3-amido-4-anilinoquinoline CSF1R inhibitor. AZ683 has high affinity for CSF1R ( K i =8 nM; IC 50 =6 nM). AZ683 has good oral bioavailability. [ 11 C]AZ683 can be used as a positron emission tomography (PET) radiotracer for colony stimulating factor 1 receptor (CSF1R) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 953798-95-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-159108. | |
| AZ7550 Mesylate | AZ7550 Mesylate is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 ?M. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZ7550 trimesylate salt. CAS No. 2319837-99-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0794B. | |
| AZ82 | AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor, with a Ki of 43 nM and an IC50 of 300 nM for KIFC1. Uses: Scientific research. Group: Signaling pathways. CAS No. 1449578-65-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12241. | |
| AZ8838 | AZ8838 is a potent, competitive, allosteric, orally active non-peptide small molecule antagonist of PAR2 with a pKi of 6.4 for hPAR2[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2100285-41-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123617. | |
| AZ960 | AZ960 is a potent and specific inhibitor of the JAK2 kinase with a Ki of 0.45 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 905586-69-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10411. | |
| Azacyclonol | Azacyclonol (γ-pipradol), a metabolite of Terfenadine, is a central depressant agent. Azacyclonol is a ganglion-blocking agent. Azacyclonol can be used to diminish psychoses-induced hallucinations [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: γ-pipradol. CAS No. 115-46-8. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-B0530. | |
| Azadirachtin | Azadirachtin is an oral active triterpenoid compound with anticancer, antimalarial, anti-inflammatory, and insecticidal activities. Azadirachtin induces cell apoptosis through the mitochondrial pathway (by inhibiting Bcl-2/Bax ratio or activating Apaf-1 and caspase-3 ) or through death receptors (by inhibiting TNFR activation). Additionally, Azadirachtin exerts its anti-inflammatory effects by inhibiting NF-?B signaling pathway activation, and it exhibits insecticidal activity by inducing apoptosis in insect cells [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Natural products. CAS No. 11141-17-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-126741. | |
| Azamethiphos | Azamethiphos is an organophosphate insecticide and a neurotoxic agent, causing acetylcholinesterase (AChE) inhibition [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 35575-96-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg. Product ID: HY-114899. | |
| Azaperone | Azaperone (R-1929) acts as a dopamine antagonist but also has some antihistaminic and anticholinergic properties. Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic agent with antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R-1929. CAS No. 1649-18-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-B1470. | |
| Azaribine | Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine) is a potent orotidine monophosphate decarboxylase (OMPD) inhibitor. Azaribine is an antiviral inhibitor of several RNA viruses and inhibits viral genome replication and gene transcription. Azaribine shows broad-spectrum antiviral activity ( EC 50 =3.80?nM-1.73?μM against influenza A and B viruses; EC 50 =1.62 μM against ZIKV Paraiba). Azaribine, a triacetate salt of Azauridine, has the potential for psoriasis research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2',3',5'-Tri-O-acetyl-6-azauridine. CAS No. 2169-64-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-B1537. | |
| Azaserine | Azazerine (CI-337) is a competitive inhibitor of glutamine amidotransferase. Azaserine is an antibiotic , it shows antibacterial activities. Azazerine shows anti-tumor activities and it may also act as a tumor inducer. Azazerine can be used for the research of cancer and infection [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CI-337; O-Diazoacetyl-L-serine; P-165. CAS No. 115-02-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0919. | |
| Azasetron hydrochloride | Azasetron (Y-25130) hydrochloride, a benzamide derivative, is a potent and selective 5-HT3 receptor antagonist. Azasetron is used in the study for Chemotherapy-induced nausea and vomiting (CINV) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Y-25130 hydrochloride. CAS No. 123040-16-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0068. | |
| Azathioprine | Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis [1] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BW 57-322. CAS No. 446-86-6. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-B0256. | |
| AZD0095 | AZD0095 is a selective and orally active MCT4 inhibitor (IC50: 1.3 nM). AZD0095 effectively inhibits the tumor growth in NCI-H358 xenograft in combination with Cediranib (HY-10205)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2750001-23-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-148517. | |
| AZD0156 | AZD0156 is a potent, selective and orally active ATM inhibitor with an IC 50 of 0.58 nM. AZD0156 inhibits the ATM -mediated signaling, prevents DNA damage checkpoint activation, disrupts DNA damage repair, and induces tumor cell apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1821428-35-6. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100016. | |
| AZD0780 | PCSK9-IN-12 is a heteroaryl compound. PCSK9-IN-12 has bind affinity for PCSK9 with a K d value of ?200 nM. PCSK9-IN-12 can be used for the research of cholesterol metabolism [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PCSK9-IN-12. CAS No. 2455427-91-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148673. | |
| AZD1080 | AZD1080 is a potent and selective GSK3 inhibitor. AZD1080 inhibits recombinant human GSK3? and GSK3? with pKi (IC50) of 8.2 (6.9 nM) and 7.5 (31 nM), respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 612487-72-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13862. | |
| AZD1208 | AZD1208 is an orally bioavailable, highly selective PIM kinases inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1204144-28-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15604. | |
| AZD1390 | AZD1390 is a potent, highly selective, orally bioavailable, brain-penetrant ATM inhibitor with an IC 50 of 0.78 nM in cell [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2089288-03-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109566. | |
| AZD-1480 | AZD-1480 is an ATP-competitive inhibitor of JAK1 and JAK2 with IC50s of 1.3 nM and <0.4?nM, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 935666-88-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10193. | |
| AZD1656 | AZD1656 is a potent, selective and orally active glucokinase activator with an EC 50 of 60 nM. AZD1656 has the potential for type 2 diabetes research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 919783-22-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15675. | |
| AZD1981 | AZD1981 is a potent and selective CRTh2 antagonist; displaces radio-labelled PGD2 from human recombinant DP2 with high potency (pIC50 = 8. Uses: Scientific research. Group: Signaling pathways. CAS No. 802904-66-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15950. | |
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