MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| ART26.12 | ART26.12 is an orally active FABP5 inhibitor with anti-cannabinoid properties. ART26.12 effectively prevents and alleviates Oxaliplatin (HY-17371)-induced pain through lipid modulation and cannabinoid receptor activation [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2766800-24-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-159115. |  |
| ART558 | ART558 is a potent, selective and allosteric DNA polymerase theta (Pol?) inhibitor (IC50=7.9 nM). ART558 elicits BRCA-gene synthetic lethality and DNA damage. ART558 can be used for the research of cancer, such as breast cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2603528-97-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141520. | |
| ART812 | ART812 is an orally active DNA polymerase Pol? inhibitor with an IC50 value of 7.6 nM. ART812 has an IC50 value of 240 nM for cell based microhomology-mediated end joining (MMEJ)[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2607138-82-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139289. | |
| Arteannuin B | Arteannuin B, No. 2000 can be jointly submitted with the blue material. Arteannuin B had anti-SARS-CoV-2 activity, EC 50 =10.28 μM [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 50906-56-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N2016. | |
| Artemether | Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224. CAS No. 71963-77-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-N0402. | |
| Artemisic acid | Artemisinic acid (Qing Hao acid), an amorphane sesquiterpene isolated from Artemisia annua L., possesses a variety of pharmacological activity, such as antimalarial activity, anti-tumor activity, antipyretic effect, antibacterial activity, allelopathy effect and anti-adipogenesis effect [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Qing Hao acid; Artemisinic acid; Arteannuic acid. CAS No. 80286-58-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-N1984. | |
| Artemisinin | Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants [1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Qinghaosu; NSC 369397. CAS No. 63968-64-9. Pack Sizes: 10 mM * 1 mL; 200 mg; 500 mg; 1 g. Product ID: HY-B0094. | |
| Artemisitene | Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 101020-89-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-122550. | |
| Artemotil | Artemotil (β-Arteether) has antimalarial activity for the treatment of chloroquine-resistant Plasmodium falciparum malaria with an IC 50 of 1.61 nM. Artemotil also has central nervous system (CNS) neurotoxicity and anorectic toxicity in rats, dogs and monkeys [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: β-Arteether; (+)-Arteether; Arteether. CAS No. 75887-54-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0770. | |
| Artepillin C | Artepillin C has gastroprotective, anti-inflammatory, antimicrobial, antioxidant, antitumor and choleretic activity. Artepillin C can be isolated from Brazilian green propolis [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 72944-19-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N10319. | |
| Arterolane | Arterolane is an antimalarial agent, with IC 50 of both 1.1 nM against P. falciparum Ro73 and W2, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: OZ 277; RBx 11160. CAS No. 664338-39-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10852. | |
| Artesunate | Artesunate is an inhibitor of both STAT-3 and exported protein 1 ( EXP1 ). Uses: Scientific research. Group: Natural products. CAS No. 88495-63-0. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-N0193. | |
| Articaine hydrochloride | Articaine hydrochloride (Hoe-045) is an amide agent that can suppress or relieve pain, containing an ester group, reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, can provide effective pain relief. Articaine hydrochloride ameliorates LPS-induced acute kidney injury via inhibition of NF-κB activation and the NLRP3 inflammasome pathway [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Hoe-045. CAS No. 23964-57-0. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-B0516. | |
| ART-IN-1 | ART-IN-1 (compound 7) is a selective PARP inhibitor with IC 50 s of 19, 22, 2.4, >100, 1.1 μM for PARP2, TNKS2, PARP10, PARP14, PARP15, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2418014-98-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-143338. | |
| ar-Turmerone | ar-Turmerone ((+)-ar-Turmerone) is a major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities [1] [2] [3]. ar-Turmerone activates apoptotic protein in human lymphoma U937 cells [3]. ar-Turmerone exerts positive modulation on murine DCs. ar-Turmerone induces NSC proliferation and constitutes a promising therapeutic agent for various neurologic disorders [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: (+)-ar-Turmerone. CAS No. 532-65-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N6703. | |
| ARV-393 | ARV-393 is a potent and orally active BCL6 PROTAC degrader. ARV-393 induces ubiquitination of BCL6 and its subsequent degradation by the proteasome. ARV-393 has the potential for the research of advanced non-hodgkin lymphoma[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2851885-95-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158105. | |
| ARV-771 | ARV-771 is a potent BET PROTAC based on E3 ligase von Hippel-Lindau with Kds of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1949837-12-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100972. | |
| ARV-825 | ARV-825 is a PROTAC connected by ligands for Cereblon and BRD4. ARV-825 binds to BD1 and BD2 of BRD4 with Kds of 90 and 28 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1818885-28-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-16954. | |
| Arvanil | Arvanil is a ligand for vanilloid receptor 1 (VR1) and cannabinoid 1 (CB1). Arvanil can inhibit spasticity, as a potent neuroprotectant [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N-Vanillylarachidonamide. CAS No. 128007-31-8. Pack Sizes: 5 mg (113.73 mM * 100 μL in Ethanol); 10 mg (113.73 mM * 200 μL in Ethanol). Product ID: HY-103333. | |
| Arzoxifene hydrochloride | Arzoxifene (LY353381) hydrocloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY353381 hydrochloride; SERM III hydrochloride. CAS No. 182133-27-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-13556A. | |
| AS 1411 sodium | AS1411 sodium is a quadruplex-forming oligonucleotide aptamer that targets nucleolin. It has anti-tumor activity. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AGRO-100 sodium. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-147081A. | |
| AS1517499 | AS1517499 is a potent and brain-permeable STAT6 phosphorylation inhibitor with an IC50 of 21 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 919486-40-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100614. | |
| AS1810722 | AS1810722 is an orally active and potent STAT6 inhibitor with an IC50 of 1.9 nM. AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722, a derivative of fused bicyclic pyrimidine, has the potential for allergic diseases such as asthma and atopic diseases research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 909561-15-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134772. | |
| AS1842856 | AS1842856, a specific Foxo1 inhibitor (IC50=30 nM), potently suppresses autophagy[1]. AS1842856 reduces Foxo1 activity and, to a lesser extent, inhibits Foxo1 protein expression by simply binding to Foxo1[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 836620-48-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-100596. | |
| AS1949490 | AS1949490 is a potent, orally active, selective SHIP2 phosphatase inhibitor with IC50 values of 0.34, 0.62, 13, >50, >50, and >50 μM for Mouse SHIP2, Human SHIP2, Human SHIP1, Human PTEN, Human synaptojanin, and Human myotubularin, respectively. AS1949490 increases the phosphorylation of Akt, glucose consumption and glucose uptake. AS1949490 activates intracellular insulin signalling pathways. AS1949490 can be used for research of diabetes[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1203680-76-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-18686. | |
| AS2717638 | AS2717638 is a highly selective, brain-penetrant and orally active lysophosphatidic acid receptor 5 (LPA5) antagonist with an IC50 value of 38 nM. AS2717638 is highly selective and shows no significant antagonistic activity against other LPA receptors (LPA1, LPA2, and LPA3). AS2717638 can be used in the research of pain and neuroinflammation-related diseases[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2148339-28-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114379. | |
| AS2863619 | AS2863619 enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 inhibition of CDK8/19, which consequently activates the Foxp3 gene[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2241300-51-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-126675A. | |
| AS601245 | AS601245 is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 345987-15-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-11010. | |
| AS8351 | AS8351 (NSC51355) is a KDM5B inhibitor, which can induce and sustain active chromatin marks to facilitate the induction of cardiomyocyte-like cells[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC51355. CAS No. 796-42-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100744. | |
| AS-85 | AS-85 is a potent ASH1L histone methyltransferase inhibitor ( IC 50 =0.6 μM) with anti-leukemic activity. AS-85 strongly binds to the ASH1L SET domain, with the K d value of 0.78?μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2323623-80-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141430. | |
| (-)-Asarinin | (-)-Asarinin is a extract lignan from Asarum sieboldii Miq., mainly produced in roots of this herb [1]. Uses: Scientific research. Group: Natural products. CAS No. 133-04-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N0701. | |
| Asatone | Asatone is an active component isolated from Radix et Rhizoma Asari, with anti-inflammatory effect via activation of NF-κB and donwn regulation of p-MAPK (ERK, JNK and p38) pathways [1]. Uses: Scientific research. Group: Natural products. CAS No. 38451-63-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-N6826. | |
| Ascaridole | Ascaridole is an anthelmintic and also has antimalarial activity [1]. Uses: Scientific research. Group: Natural products. CAS No. 512-85-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-118494. | |
| Asciminib | Asciminib (ABL001) is a potent and selective allosteric BCR-ABL1 inhibitor, which inhibits Ba/F3 cells grown with an IC 50 of 0.25 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABL001. CAS No. 1492952-76-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104010. | |
| Asciminib hydrochloride | Asciminib (ABL001) hydrochloride is a potent and selective allosteric BCR-ABL1 inhibitor, which inhibits Ba/F3 cells grown with an IC 50 of 0.25 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABL001 hydrochloride. CAS No. 2119669-71-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104010A. | |
| Ascomycin | Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Immunomycin; FR-900520; FK520. CAS No. 104987-12-4. Pack Sizes: 10 mM * 1 mL; 10 mg; 50 mg; 100 mg. Product ID: HY-13557. | |
| Ascorbate oxidase, Cucurbit sp. | Ascorbate oxidase, Cucurbit sp., also known as vitamin C oxidase, is a REDOX enzyme involved in the regulation of extracellular matrix. Ascorbate oxidase catalyzes the reaction of ascorbic acid and oxygen to produce dehydroascorbic acid [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ASO, Cucurbit sp. CAS No. 9029-44-1. Pack Sizes: 100 U; 500 U; 1000 U. Product ID: HY-P2742. | |
| Ascorbyl palmitate | Ascorbyl palmitate is an orally active ester formed from ascorbic acid and palmitic acid, used as an antioxidant and food additive. Ascorbyl palmitate in preventing fat and oil oxidation is more efficient than Butylated hydroxyanisole (HY-B1066) and Butylated hydroxytoluene (HY-Y0172). Ascorbyl palmitate mitigates inhibition of collagen synthesis by select calcium and sodium channel blockers. Ascorbyl palmitate induces Apoptosis in human umbilical vein endothelial cells (HUVECs). Ascorbyl palmitate ameliorates inflammatory diseases by inhibition of NLRP3 inflammasome [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: L-Ascorbic acid 6-hexadecanoate; 6-O-Palmitoyl-L-ascorbic acid. CAS No. 137-66-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-B0987. | |
| Ascr#18 | Ascr#18, an ascaroside, is a hormone of nematodes. Ascr#18 is expressed during nematode development. Ascr#18 increases resistance in Arabidopsis, tomato, potato and barley to viral, bacterial, oomycete, fungal and nematode infections[1]. Uses: Scientific research. Group: Natural products. CAS No. 1355681-10-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N8393. | |
| Ascr#2 | Ascr#2 (Ascaroside C6) is an ascaroside isolated from Caenorhabditis elegans, potently promotes dauer formation, and also acts as a potent male attractant combined with Ascr#3 (HY-N6977) at low concentration[1]. Uses: Scientific research. Group: Natural products. Alternative Names: Ascaroside C6. CAS No. 946524-24-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N6974. | |
| Ascr#3 | Ascr#3 is a type of pheromone found in the beautiful nematode, and when mixed with ascr#2, it can act as a male attractant and also induce the formation of dauer (the dormant larval stage). Ascr#3 can counteract the effects caused by male-enriched Ascr#10[1][2]. Uses: Scientific research. Group: Natural products. CAS No. 946524-26-1. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-N6977. | |
| Ascrinvacumab | Ascrinvacumab (PF-03446962) is a human IgG2 monoclonal antibody targets ALK-1. Ascrinvacumab shows binding efficiency with human ALK1 with a K d value of 7 nM. Ascrinvacumab can be used for the research of hepatocellular carcinoma (HCC) [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Anti-ACVRL1 / ALK-1 Reference Antibody (ascrinvacumab); PF-03446962. CAS No. 1463459-96-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99353. | |
| ASCT2-IN-1 | ASCT2-IN-1 (compound 20k) is an ASCT2 inhibitor with IC 50 values of 5.6 μM and 3.5 μM in cells A549 and HEK293, respectively. ASCT2-IN-1 induces cell apoptosis. ASCT2-IN-1 inhibits tumor growth [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3032651-18-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-163198. | |
| Asenapine | Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors ( pK i : 8.4-10.5), adrenoceptors ( pK i : 8.9-9.5), dopamine receptors ( pK i : 8.9-9.4) and histamine receptors ( pK i : 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Org 5222. CAS No. 65576-45-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10121. | |
| Asenapine hydrochloride | Asenapine hydrochloride, an antipsychotic, is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and Dopamine (D 2 , D 3 , D 4 ) receptor antagonist with K i values of 0.03-4.0 nM for 5-HT and 1.3, 0.42, 1.1 nM for Dopamine receptor, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1412458-61-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16567. | |
| Asenapine maleate | Asenapine maleate is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and D2 antagonist with K i values of 0.03-4.0 nM, 1.3nM, respectively, and an antipsychotic. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Org 5222 maleate. CAS No. 85650-56-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-11100. | |
| Asfotase alfa | Asfotase alfa (ENB-0040) is a bone-targeted genetically engineered glycoprotein. Asfotase alfa increases the survival rate, bone mineralization and bone length and prevents mineralization defects of the feet, rib cage, lower limbs, jaw bones in Akp2 / knockout mice. Asfotase alfa can be used for the research of perinatal, infantile, and juvenile-onset hypophosphatasia (HPP) [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: ENB-0040. CAS No. 1174277-80-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-108786. | |
| Asiatic acid | Asiatic acid, a pentacyclic triterpene found in Centella asiatica ( Centella asiatica ), has anticancer activity. Asiatic acid induces apoptosis in melanoma cells and has barrier protective effects on human aortic endothelial cells (HAEC). Asiatic acid also has anti-inflammatory activity and inhibits tumor necrosis factor (TNF)-α-induced endothelial barrier dysfunction. Asiatic acid also inhibits NLRP3 inflammasome activation and NF-κB pathway, effectively inhibits inflammation in rats, and has neuroprotective effects in rat spinal cord injury (SCI) model [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 464-92-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0194. | |
| Asiaticoside | Asiaticoside, a trisaccaride triterpene from Centella asiatica , suppresses TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts; Asiaticoside shows antioxidant, anti-inflammatory, and anti-ulcer properties. Uses: Scientific research. Group: Natural products. CAS No. 16830-15-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0439. | |
| Asimadoline hydrochloride | Asimadoline (EMD-61753) hydrochloride is an orally active, selective and peripherally active κ-opioid agonist with IC 50 s of 5.6 nM (guinea pig) and 1.2 nM (human recombinant). Asimadoline hydrochloride has low permeability across the blood brain barrier and has peripheral anti-inflammatory actions. Asimadoline hydrochloride ameliorates allodynia in diabetic rats and has the potential for irritable bowel syndrome (IBS) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EMD-61753 hydrochloride. CAS No. 185951-07-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-107384A. | |
| Asivatrep | Asivatrep (PAC-14028) is a potent and selective transient receptor potential vanilloid type I ( TRPV1 ) antagonist. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PAC-14028. CAS No. 1005168-10-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12777. | |
| ASK1-IN-1 | ASK1-IN-1 is a CNS-penetrant ASK1 (apoptosis signal-regulating kinase 1) inhibitor, with good potency (cell IC 50 =138 nM; Biochemical IC 50 =21 nM) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2411382-24-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133554. | |
| ASN007 | ASN007 (ERK-IN-3) is a potent and orally active inhibitor of ERK. ASN007 inhibits ERK1/2 with low single-digit nM IC 50 values. ASN007 can be used for the research of cancers driven by RAS mutations [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ERK-IN-3. CAS No. 2055597-12-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136579. | |
| ASN007 benzenesulfonate | ASN007 (ERK-IN-3) benzenesulfonate is a potent and orally active inhibitor of ERK. ASN007 benzenesulfonate inhibits ERK1/2 with low single-digit nM IC 50 values. ASN007 benzenesulfonate can be used for the research of cancers driven by RAS mutations [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ERK-IN-3 benzenesulfonate. CAS No. 2055597-39-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136579A. | |
| Asnuciclib | Asnuciclib (CDKI-73; LS-007) is an orally active and highly efficacious CDK9 inhibitor, with Ki values of 4 nM, 4 nM and 3 nM for CDK9, CDK1 and CDK2, respectively. Asnuciclib down-regulates the RNAPII phosphorylation. Asnuciclib is also a novel pharmacological inhibitor of Rab11 cargo delivery and innate immune secretion[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CDKI-73; LS-007. CAS No. 1421693-22-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12445. | |
| ASO 556089 sodium | ASO 556089 sodium is a 16 nucleotide length gapmer (3-10-3) that targets the human and mouse long non-coding RNA MALAT1, with the sequence: 5-GmCATTmCTAATAGmCAGmC-3 [1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-148688. | |
| Asoprisnil | Asoprisnil (J867), a selective progesterone receptor modulator, exhibits mixed progesterone agonist and antagonist effects on various progesterone targeted tissues in animal and human [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: J867. CAS No. 199396-76-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-119433. | |
| ASP2535 | ASP2535 is a potent, orally bioavailable, selective, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor. ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer's disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 374886-51-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-110176. | |
| ASP5878 | ASP5878 is an oral active inhibitor of FGFR 1, 2, 3, and 4 , with IC 50 values of 0.47 nM, 0.6 nM, 0.74 nM and 3.5 nM for FGFR 1, 2, 3, and 4 kinase activity. ASP5878 has potential antineoplastic activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1453208-66-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19983. | |
| ASP7663 | ASP7663 is an orally active and selective TRPA1 agonist. ASP7663 exerts both anti-constipation and anti-abdominal pain actions [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1190217-35-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101907. | |
| ASP-9521 | ASP-9521 is a potent, selective and orally available AKR1C3 inhibitor with an IC50 of 11 nM for human AKR1C3. Uses: Scientific research. Group: Signaling pathways. CAS No. 1126084-37-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-19903. | |
| Asparagusic acid | Asparagusic acid is a sulfur-containing flavor component produced by Asparagus officinalis Linn., with anti-parasitic effect. Asparagusic acid is a plant growth inhibitor [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 2224-2-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50730. | |
| Aspartame | Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: SC-18862. CAS No. 22839-47-0. Pack Sizes: 500 mg; 1 g; 5 g. Product ID: HY-B0361. | |
| Aspartame (Standard) | Aspartame (Standard) is the analytical standard of Aspartame. This product is intended for research and analytical applications. Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 22839-47-0. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-B0361R. | |
| Aspartate aminotransferase, Genetically engineered bacteria | Aspartate aminotransferase, Genetically engineered bacteria (EC 2.6.1.1) (AST) is a transaminase enzyme, is often used in biochemical studies. Aspartate aminotransferase catalyzes aspartate and alpha-ketoglutarate converts to oxaloacetate and glutamate. Aspartate aminotransferase can be found in cerebrospinal fluid, exudates, and transudates [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EC 2.6.1.1; GOT; AST. CAS No. 9000-97-9. Pack Sizes: 200 U; 1 KU. Product ID: HY-P3016. | |
| (-)-Aspartic acid | (-)-Aspartic acid is a pyroptosis inhibitor. (-)-Aspartic acid acts as a neurotransmitter and neuromodulator, participates in hormone synthesis and regulation, and plays a role in nervous system development and endocrine system [5]. Uses: Scientific research. Group: Natural products. Alternative Names: (R)-Aspartic acid; D-(-)-Aspartic acid. CAS No. 1783-96-6. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g; 25 g; 50 g. Product ID: HY-42068. | |
| Aspartic acid calcium | Aspartic acid calcium (Calcium L-aspartate) is a chelate where calcium is attached to an amino acid naming L-Aspartic acid. L-Aspartic acid is an amino acid and serves as a building block for proteins in the body. Uses: Scientific research. Group: Natural products. Alternative Names: Calcium L-aspartate. CAS No. 10389-09-0. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-N0666B. | |
| Aspergillopepsin I | Aspergillopepsin I (Aspergillus acid protease) is an aspartic endopeptidase that catalyses the hydrolysis of peptide bonds in proteins, with broad specificity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Aspergillus acid protease. CAS No. 9025-49-4. Pack Sizes: 5 g. Product ID: HY-P2973. | |
| Asperosaponin VI | Asperosaponin VI, A saponin component from Dipsacus asper , induces osteoblast differentiation through BMP?2/p38 and ERK1/2 pathway [1]. Asperosaponin ? inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB [2]. Uses: Scientific research. Group: Natural products. CAS No. 39524-08-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N0265. | |
| Asperuloside | Asperuloside is an iridoid isolated from Hedyotis diffusa , with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase ( iNOS ), suppresses NF-κB and MAPK signaling pathways [1]. Uses: Scientific research. Group: Natural products. CAS No. 14259-45-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N1382. | |
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