MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| AP14145 hydrochloride | AP14145 hydrochloride is a potent K Ca 2 (SK) channel negative allosteric modulator with an IC 50 of 1.1 μM for K Ca 2.2 (SK2) and K Ca 2.3 (SK3) channels. AP14145 hydrochloride inhibition strongly depends on two amino acids, S508 and A533 in the channel. AP14145 hydrochloride prolonged atrial effective refractory period (AERP) in rats and demonstrates antiarrhythmic effects in a Vernakalant-resistant porcine model of atrial fibrillation (AF) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2387505-59-9. Pack Sizes: 5 mg. Product ID: HY-120355A. |  |
| AP1867 | AP1867 is a synthetic FKBP12F36V-directed ligand[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 195514-23-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114434. | |
| AP20187 | AP20187 (B/B Homodimerizer) is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions. Uses: Scientific research. Group: Signaling pathways. Alternative Names: B/B Homodimerizer. CAS No. 195514-80-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13992. | |
| AP30663 | AP30663 is a KCa2 channel inhibitor that can be used for the study of atrial fibrillation[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-157557. | |
| AP39 | AP39 is a triphenylphosphonium derivatised anethole dithiolethione and mitochondria-targeting hydrogen sulfide (H2S) donor. AP39 increases intracellular H2S levels. AP39 exerts cytoprotective effects and maintains mitochondrial DNA integrity under oxidative stress conditions. AP39 protects against myocardial reperfusion injury in mice model and has the potential for Alzheimer's disease research[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1429061-80-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126124. | |
| AP-6 | AP-6 is a selective inhibitor of TMEM175 with activity in modulating lysosomal function. Acute inhibition of TMEM175 by AP-6 increases lysosomal macromolecular catabolism, thereby accelerating macrophage and other digestive processes. AP-6 may be used in Parkinson's disease research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1369963-51-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161949. | |
| AP 811 | AP 811 is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a K i of 0.48 nM. AP 811 displays >20000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 124833-45-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1419. | |
| Apabetalone | Apabetalone (RVX-208) is an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. The IC 50 s are 87 μM and 0.51 μM for BD1 and BD2 , respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RVX-208; RVX000222. CAS No. 1044870-39-4. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16652. | |
| Apafant | Apafant (WEB 2086) is a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a Ki of 9.9 nM. Apafant increases the gene expression of PAF-r, ?-globin, ?-globin, decreases the c-myb gene expression. Apafant shows a protective effect on alkyl-PAF-mediated lethalit[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: WEB 2086. CAS No. 105219-56-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-108634. | |
| Apalutamide | Apalutamide (ARN-509) is a potent and competitive androgen receptor ( AR ) antagonist, binding AR with an IC 50 of 16 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ARN-509. CAS No. 956104-40-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-16060. | |
| Apamin | Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity[1]. Uses: Scientific research. Group: Peptides. Alternative Names: Apamine. CAS No. 24345-16-2. Pack Sizes: 500 ?g; 1 mg. Product ID: HY-P0256. | |
| Apatinib-d8 free base | Apatinib-d 8 (free base) is the deuterium labeled Apatinib free base[1]. Apatinib free base (YN968D1 free base) is an orally bioavailable tyrosine kinase inhibitor, which selectively targets VEGFR-2 (IC50=1 nM). Apatinib free base (YN968D1 free base) is an anti-angiogenic drug for the research of advanced or metastatic gastric cancer. Apatinib free base (YN968D1 free base) potently inhibits Ret, c-Kit and c-Src with IC50s of 13, 429 and 530 nM, respectively. It also inhibits cellular phosphorylation of VEGFR-2, c-kit and PDGFRβ[2][3][4]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: YN968D1-d8 free base. CAS No. 2468771-43-7. Pack Sizes: 1 mg. Product ID: HY-13342AS. | |
| Apatinib-d8 hydrochloride | Apatinib-d 8 (hydrochloride) is the deuterium labeled Apatinib hydrochloride[1]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 2468771-44-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-13342S. | |
| Apatorsen sodium | Apatorsen (sodium) is an antisense oligonucleotide designed to bind to Hsp27 mRNA, resulting in the inhibition of the production of Hsp27 protein. Uses: Scientific research. Group: Signaling pathways. Alternative Names: OGX-427 sodium. CAS No. 915443-09-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-145722. | |
| APC 366 | APC 366 is a selective inhibitor of mast cell tryptase ( K i =7.1 μM). APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 158921-85-8. Pack Sizes: 5 mg. Product ID: HY-105999. | |
| Apcin | Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. Apcin occupes the D-box-binding pocket on the side face of the WD40-domain and can prolong mitosis[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 300815-04-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110287. | |
| Apelin-12 | Apelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect [1] [2] [3]. Uses: Scientific research. Group: Peptides. CAS No. 229961-08-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2537. | |
| Apelin-13 TFA | Apelin-13 TFA is an endogenous ligand for the G-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with an EC 50 value of 0.37 nM. Apelin-13 TFA has vasodilatory and antihypertensive effects. Apelin-13 TFA also can be used for researching type 2 diabetes and metabolic syndrome[1][2][3]. Uses: Scientific research. Group: Peptides. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1944A. | |
| Apelin-17(human, bovine) | Apelin-17(human, bovine) is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17(human, bovine) binds to human APJ receptors expressed in HEK 293 cells (pIC50=9.02). Apelin-17(human, bovine) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ[1][2][3]. Uses: Scientific research. Group: Peptides. CAS No. 217082-57-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P1066. | |
| Apelin-36(human) | Apelin-36(human) is an endogenous orphan G protein-coupled receptor APJ agonist, with an EC 50 of 20 nM. Apelin-36(human) shows high affinity to human APJ receptors expressed in HEK 293 cells (pIC 50 =8.61). Apelin-36 has been linked to two major types of biological activities: cardiovascular and metabolic. Apelin-36(human) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ [1] [2] [3] [4]. Uses: Scientific research. Group: Peptides. CAS No. 252642-12-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P1064. | |
| APF | APF is a fluorescence probe that can selectively, and dose dependently detect certain species among ROS and that are highly resistant to autoxidation. APF can be used in enzymatic and cellular systems [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 359010-70-1. Pack Sizes: 500 μg (11.81 mM * 100 μL in Methyl acetate). Product ID: HY-119977. | |
| APG-2449 | APG-2449 is an orally active ALK/ROS1/FAK inhibitor. APG-2449 shows antitumor activity in mouse models of non-small cell lung cancer (NSCLC) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2196186-84-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155163. | |
| Aphidicolin | Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering DNA polymerase activity. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola , inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 38966-21-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N6733. | |
| APHS | APHS is a specific and covalent COX-2 inhibitor with neuroprotective effects. COX-2 is a prostaglandin (PG) synthetase overexpressed in colorectal cancer (CRC) and has pleiotropic cancer-promoting effects. APHS modifies COX-2 by acetylating the active site (serine 516), thereby inhibiting prostaglandin production. The neuroprotective activity of APHS is inhibited by prostaglandin E2. APHS also co-inhibits the WNT pathway, an anti-tumor mechanism in addition to COX-2 inhibition [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 209125-28-0. Pack Sizes: 1 mg (38.11 mM * 100 μL in Methyl acetate); 5 mg (38.11 mM * 500 μL in Methyl acetate); 10 mg (38.11 mM * 1 mL in Methyl acetate). Product ID: HY-129284. | |
| Apicidin | Apicidin (OSI 2040) is a fungal metabolite, acts as an orally active histone deacetylase 7/8 ( HDAC7/8 ) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity. Apicidin can be used for cancer research [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: OSI 2040. CAS No. 183506-66-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N6735. | |
| Apigenin | Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a K i of 2 μM. Uses: Scientific research. Group: Natural products. Alternative Names: 4',5,7-Trihydroxyflavone; Apigenol; C.I. Natural Yellow 1. CAS No. 520-36-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-N1201. | |
| Apigenin 7-glucoside | Apigenin-7-glucoside (Apigenin-7-O-β-D-glucopyranoside) exhibits significant anti-proliferative and antioxidant activity and scavenges reactive oxygen species (ROS) [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Apigenin-7-O-β-D-glucopyranoside; Cosmosiin; Apigetrin. CAS No. 578-74-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0578. | |
| Apigenin-7-glucuronide | Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 ?M for MMP-3, MMP-8, MMP-9, MMP-13, respectively. Uses: Scientific research. Group: Natural products. Alternative Names: Apigenin 7-O-glucuronide. CAS No. 29741-09-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N1454. | |
| AP-III-a4 | AP-III-a4 (ENOblock) is a nonsubstrate analogue enolase inhibitor with an IC 50 of 0.576 uM. AP-III-a4 can be used for the research of cancer and diabetic [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ENOblock. CAS No. 1177827-73-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15858. | |
| AP-III-a4 hydrochloride | AP-III-a4 (ENOblock) hydrochloride is a nonsubstrate analogue enolase inhibitor with an IC 50 of 0.576 uM. AP-III-a4 hydrochloride can be used for the research of cancer and diabetic [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ENOblock hydrochloride. CAS No. 2070014-95-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15858A. | |
| Apiin | Apiin, a major constituent of Apium graveolens leaves with anti-inflammatory properties. Apiin shows significant inhibitory activity on nitrite (NO) production (IC 50 = 0.08 mg/mL) in-vitro and iNOS expression (IC 50 = 0.049 mg/ mL) in LPS-activated J774.A1 cells [1]. Uses: Scientific research. Group: Natural products. CAS No. 26544-34-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N0577. | |
| Apilimod | Apilimod (STA 5326) is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC 50 s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively [1]. Apilimod is a potent and highly selective PIKfyve inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: STA 5326; LAM-002A free base; AIT-101. CAS No. 541550-19-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14644. | |
| Apilimod mesylate | Apilimod (STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC 50 s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively [1]. Apilimod is a potent and highly selective PIKfyve inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: STA 5326 mesylate; LAM-002A; AIT-101 mesylate. CAS No. 870087-36-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14644A. | |
| Apimostinel | Apimostinel (NRX-1074; AGN-241660) is an orally active NMDA receptor partial agonist [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NRX-1074; AGN-241660. CAS No. 1421866-48-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102053. | |
| Apinocaltamide | Apinocaltamide (ACT-709478) is a potent, selective, orally active, and brain penetrating T-type calcium channel blocker. ACT-709478 is used in the research of generalized epilepsies [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ACT-709478. CAS No. 1838651-58-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112723. | |
| Apitegromab | Apitegromab (SRK-015) is an anti-promyostatin monoclonal antibody. Apitegromab can be used for the research of neuromuscular disease including spinal muscular atrophy [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: SRK-015. CAS No. 2278276-46-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99441. | |
| Apitolisib | Apitolisib (GDC-0980; GNE 390; RG 7422) is a selective, potent, orally bioavailable Class I PI3 kinase and mTOR kinase ( TORC1 / 2 ) inhibitor with IC 50 s of 5 nM/27 nM/7 nM/14 nM for PI3Kα /PI3Kβ /PI3Kδ /PI3Kγ , and with a K i of 17 nM for mTOR. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GDC-0980; GNE 390; RG 7422. CAS No. 1032754-93-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13246. | |
| Apixaban | Apixaban (BMS-562247-01) is a highly selective, reversible and orally active inhibitor of Factor Xa with K i of 0.08 nM and 0.17 nM in human and rabbit, respectively [1]. Apixaban is in development for the prevention and treatment of various thromboembolic diseases [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-562247-01. CAS No. 503612-47-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-50667. | |
| Apixaban-13C,d3 | Apixaban- 13 C,d 3 is a deuterium and 13 C labeled Apixaban. Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively[1]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: BMS-562247-01- 13 C,d3. CAS No. 1261393-15-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-50667S. | |
| Aplaviroc hydrochloride | Aplaviroc (AK 602) hydrochloride, a SDP derivative, is a CCR5 antagonist, with IC 50 s of 0.1-0.4 nM for HIV-1 Ba-L , HIV-1 JRFL and HIV-1 MOKW. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AK602 hydrochloride; GSK-873140 hydrochloride; GW-873140 hydrochloride. CAS No. 461023-63-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17450A. | |
| APNEA | APNEA (N6-[2-(4-Aminophenyl)ethyl]adenosine) is a potent, non-selective A3 adenosine receptor agonist. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N6-[2-(4-Aminophenyl)ethyl]adenosine. CAS No. 89705-21-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18687. | |
| ApoA-I mimetic peptide | ApoA-I mimetic peptide (PVLDLFRELLNELLEALKQKLK) has good lecithin:cholesterol acyl transferase ( LCAT ) activation potency. ApoA-I mimetic peptide can be used for synthesis of peptide/lipid complex [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 221882-20-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5282. | |
| Apoatropine hydrochloride | Apoatropine hydrochloride a tropane alkaloid isolated from Atropa belladonna [1]. Uses: Scientific research. Group: Natural products. CAS No. 5978-81-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-105797A. | |
| APOBEC3G-IN-1 | APOBEC3G-IN-1 (MN136.0185) is a potent HIV inhibitor, targeting APOBEC3G [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 14261-92-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W279260. | |
| Apo-Bovine Transferrin | Apo-Bovine Transferrin refers to iron free Transferrin (HY-P3267), serves as Transferrin receptor ligand and mediates iron release from endothelial cells. Apo-Transferrin can directly bind to hephaestin, which can convert Fe 2+ to Fe 3+. Apo-Transferrin mediates iron efflux most likely in cooperation with ferroportin 1. Apo-Bovine Transferrin can be used in neuroretinal research [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 11096-37-0. Pack Sizes: 100 mg. Product ID: HY-P3267A. | |
| Apocynin | Apocynin is a selective NADPH-oxidase inhibitor with an IC 50 of 10 μM [1] [2]. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model [3]. Apocynin can also be used for cancer research [4]. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass [5]. Uses: Scientific research. Group: Natural products. Alternative Names: Acetovanillone. CAS No. 498-02-2. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-N0088. | |
| APOL1-IN-1 | APOL1-IN-1 is a apolipoprotein L1 (APOL1) inhibitor extracted from patent WO2020131807A1 compound 87. APOL1-IN-1 can be used for the research of focal segmental glomerulosclerosis (FSGS) and non-diabetic kidney disease (NDKD) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2446817-72-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141885. | |
| Apomine | Apomine (SR-45023A) is an antineoplastic agent that inhibits the mevalonate/isoprenoid pathway in cholesterol synthesis. Apomine can accelerate the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR). Apomine can also inhibit the growth of various types of cancer cells, including lung cancer, colon cancer, breast cancer, and skin cancer. In addition, Apomine is able to induce apoptosis in tumor cell lines derived from leukemia, colon cancer, liver cancer, ovarian cancer, and breast cancer [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SR-45023A; SR 9223i; SK&F-99085. CAS No. 126411-13-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-19671. | |
| Apomorphine | Apomorphine is an orally active agonist of Dopamine receptor. Apomorphine can be used in study Parkinson, biphasic dyskinesias, urinary dysfunction,,dystonia, dyspnoea, anismus and belching [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (-)-Apomorphine. CAS No. 58-00-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-12723. | |
| Apoptozole | Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 ?M, respectively, and can induce apoptosis. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Apoptosis Activator VII. CAS No. 1054543-47-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15098. | |
| Apraclonidine hydrochloride | Apraclonidine hydrochloride (ALO 2145), a selective α2 and weak α1 receptor agonist activity, effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution and has the ability to elevate the eye lid [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ALO 2145. CAS No. 73218-79-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-12720A. | |
| Apraglutide | Apraglutide (FE 203799), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum [1]. Uses: Scientific research. Group: Peptides. Alternative Names: FE 203799. CAS No. 1295353-98-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1714. | |
| Apramycin sulfate | Apramycin (EBL 1003) sulfate is an orally active, acidic pH tolerant and aminoglycoside-modifying-enzymes-tolerant aminoglycoside antibiotic which inhibits protein biosynthesis by targeting the bacterial ribosome. Apramycin sulfate is a potential anti-drug-resistance antibiotic [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Nebramycin II sulfate. CAS No. 65710-07-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-B1329. | |
| Apratastat | Apratastat (TMI-005) is an orally active, non-selective and reversible TACE/MMPs inhibitor, can inhibit inhibit the release of TNF-?. Apratastat has the potential to overcome radiotherapy-resistance in non-small cell lung cancer (NSCLC)[1][2]. Apratastat is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TMI-005. CAS No. 287405-51-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-119307. | |
| Apremilast | Apremilast (CC-10004) is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase ( PDE-4 ) with an IC 50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC 50 of 104 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CC-10004. CAS No. 608141-41-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12085. | |
| Aprepitant | Aprepitant (MK-0869) is a selective and high-affinity neurokinin 1 receptor antagonist with a K d of 86 pM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-0869; MK-869; L-754030. CAS No. 170729-80-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10052. | |
| Aprepitant-d4 | Aprepitant-d 4 is the deuterium labeled Aprepitant[1]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 1133387-60-6. Pack Sizes: 1 mg. Product ID: HY-115397. | |
| Aprindine | Aprindine is an arrhythmia inhibitor that stabilizes the cell membranes of heart muscle cells, thereby preventing abnormal electrical impulses from causing irregular heartbeats. In hematological toxicity studies, aprindine showed potential inhibitory effects on the replicative capacity of mouse and human blood cells at certain concentrations [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 37640-71-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-A0236. | |
| Aprindine hydrochloride | Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC50 of 0.23 μM. Aprindine hydrochloride has inhibitory effects on Na+/Ca2+ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias research research. Uses: Scientific research. Group: Signaling pathways. CAS No. 33237-74-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-A0236A. | |
| Aprocitentan | Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is an orally active dual ETA/ETB antagonist with IC 50 s of 3.4 nM and 987 nM, and pA 2 valus of 6.7 and 5.5, respectively. Aprocitentan is an antihypertensive agent [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ACT-132577. CAS No. 1103522-45-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15895. | |
| Apronal | Apronal (Allylisopropylacetylurea, Apronalide) can bu used for the research of neuropsychiatry disorders. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Allylisopropylacetylurea; Apronalide. CAS No. 528-92-7. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B2177. | |
| Aprotinin | Aprotinin is a bovine pancreatic trypsin inhibitor (BPTI) inhibitor which inhibits trypsin and chymotrypsin with K i s of 0.06 pM and 9 nM, respectively. Uses: Scientific research. Group: Peptides. CAS No. 9087-70-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0017. | |
| Aptiganel hydrochloride | Aptiganel hydrochloride (Cerestat) is a non-competitive NMDA receptor antagonist with neuroprotective effect. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CNS 1102. CAS No. 137160-11-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110097. | |
| APTO-253 | APTO-253 (LOR-253) is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates anticancer activity through induction of the Krüppel-like factor 4 (KLF4) tumor suppressor[1][2]. APTO-253 has antiarthritic activity[3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LOR-253; LT-253. CAS No. 916151-99-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16291. | |
| APX-115 | APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 ?M, 0.57 ?M, and 0.63 ?M for Nox1, Nox2 and Nox4, respectively. APX-115 effectively prevents kidney injury[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ewha-18278. CAS No. 1395946-75-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120801. | |
| APY0201 | APY0201 is a potent PIKfyve inhibitor, which inhibits the conversion of PtdIns3P to PtdIns(3,5)P2 in the presence of in the presence of [33P]ATP with an IC50 of 5.2 nM. APY0201 also inhibits IL-12/IL-23 production. Uses: Scientific research. Group: Signaling pathways. CAS No. 1232221-74-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15982. | |
| APY29 | APY29, an ATP-competitive inhibitor, is an allosteric modulator of IRE1? which inhibits IRE1? autophosphorylation by binding to the ATP-binding pocket with IC50 of 280 nM. APY29 acts as a ligand that allosterically activates IRE1? adjacent RNase domain[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1216665-49-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17537. | |
| Apyrase | Apyrase is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Signaling pathways. CAS No. 9000-95-7. Pack Sizes: 10 U; 100 U. Product ID: HY-P2764. | |
| AQ-13 dihydrochloride | AQ-13 dihydrochloride is an aminoquinoline antimalarial agent that is effective against drug-resistant strains of Plasmodium falciparum. Uses: Scientific research. Group: Signaling pathways. CAS No. 169815-40-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100358. | |
| AQC | AQC (6-Aminoquinolyl-N-hydroxysccinimidyl carbamate) is a reagent used for amino acid or protein sequence analysis by HPLC with fluorescence detection. AQC reacts with primary and secondary amino acids to yield fluorescent derivates, allowing amino acid detection at under-picomolar levels [1] [2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: 6-Aminoquinolyl-N-hydroxysccinimidyl carbamate. CAS No. 148757-94-2. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-117695. | |
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