MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| ATPCA hydrochloride | ATPCA hydrochloride is a selective radioactive substrate for BGT1 over GAT1/GAT3 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 185444-92-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124285. |  |
| ATP disodium salt | ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Adenosine 5'-triphosphate disodium salt; Disodium adenosine triphosphate. CAS No. 987-65-5. Pack Sizes: 500 mg; 1 g; 5 g. Product ID: HY-B0345A. | |
| ATP disodium salt hydrate | ATP disodium salt hydrate (Adenosine 5'-triphosphatedisodium salt hydrate) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt hydrate is an important endogenous signaling molecule in immunity and inflammation [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Adenosine 5'-triphosphate disodium salt hydrate. CAS No. 34369-07-8. Pack Sizes: 500 mg; 1 g; 5 g. Product ID: HY-W010735. | |
| ATP disodium trihydrate | ATP disodium trihydrate (Adenosine 5'-triphosphate disodium trihydrate) is a central component of energy storage and metabolism in vivo. ATP disodium trihydrate provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium trihydrate is an important endogenous signaling molecule in immunity and inflammation [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Adenosine-5'-triphosphate disodium trihydrate. CAS No. 51963-61-2. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B2176A. | |
| Atpenin A5 | Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM), and is an effective mKATP channel agonist and cardioprotective agent[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 119509-24-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-126653. | |
| ATP-Red 1 | ATP-Red 1 is a multisite-binding switchable fluorescent probe, and can selectively and rapidly responds to intracellular concentrations of ATP in living cells (Ex/Em = 510/590 nm). Uses: Scientific research. Group: Fluorescent dye. CAS No. 1847485-97-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-U00451. | |
| ATP (Standard) | ATP (Standard) is the analytical standard of ATP. This product is intended for research and analytical applications. ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation [1] [2]. In Vitro: ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs [3]. ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner [4]. ATP promotes neutrophil chemotaxis in vitro [4]. In Vivo: ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo [4]. ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo [4]. Uses: Scientific research. Group: Natural products. CAS No. 56-65-5. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B2176R. | |
| ATP synthase inhibitor 1 | ATP synthase inhibitor 1 is a potent inhibitor of c subunit of the F 1 /F O -ATP synthase complex, inhibits mitochondrial permeability transition pore (mPTP) opening, does not affect ATP levels [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1023043-30-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112715. | |
| Atractylenolide I | Atractylenolide I is a sesquiterpene derived from the rhizome of Atractylodes macrocephala, possesses diverse bioactivities, such as neuroprotective, anti-allergic, anti-inflammatory and anticancer properties. Atractylenolide I reduces protein levels of phosphorylated JAK2 and STAT3 in A375 cells, and acts as a TLR4 -antagonizing agent. Uses: Scientific research. Group: Natural products. CAS No. 73069-13-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-N0201. | |
| Atractylenolide II | Atractylenolide II (Asterolide) is a sesquiterpenoid compound. Atractylenolide II can induce G1 phase cell cycle arrest and apoptosis in B16 melanoma cells. Atractylenolide II is an orally effective anticancer agent that can exert anti-melanoma effects by inhibiting the STAT3 signaling pathway. In addition, Atractylenolide II has been shown to ameliorate myocardial fibrosis, oxidative stress, and neuroprotective activity [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Asterolide. CAS No. 73069-14-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-N0202. | |
| Atractylenolide III (Standard) | Atractylenolide III (Standard) is the analytical standard of Atractylenolide III. This product is intended for research and analytical applications. Atractylenolide III (ICodonolactone) is the main component of Atractylodes rhizome and has the activity of inducing apoptosis in lung cancer cells. Atractylenolide III is an orally active gastroprotective agent [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 73030-71-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0203R. | |
| Atractylodin | Atractylodin (Atractydin) is an orally active active ingredient obtained from the rhizome of Atractylodes lancea and A. chinensis. Atractylodin is a natural insecticide. Atractylodin has anti-inflammatory activity[1][2][3]. Uses: Scientific research. Group: Natural products. Alternative Names: Atractydin. CAS No. 55290-63-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0238. | |
| Atractyloside A | Atractyloside A is a natural TCM reference compound. Uses: Scientific research. Group: Natural products. CAS No. 126054-77-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0237. | |
| Atracurium besylate | Atracurium (BW-33A) besylate is a potent, competitive and non-depolarizing neuromuscular blocking agent. Atracurium besylate also is an AChR receptor antagonist. Atracurium besylate induces bronchoconstriction and neuromuscular blockade. Atracurium besylate promotes astroglial differentiation [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BW-33A. CAS No. 64228-81-5. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 500 mg. Product ID: HY-B0292A. | |
| Atranorin | Atranorin is a lichen secondary metabolite. Atranorin inhibits lung cancer cell motility and tumorigenesis by affecting AP-1, Wnt, and STAT signaling and suppressing RhoGTPase activity [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 479-20-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N2907. | |
| Atrasentan | Atrasentan (ABT-627) is an endothelin receptor antagonist with IC 50 of 0.0551 nM for ET A [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABT-627; (+)-A 127722; A-147627. CAS No. 173937-91-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15403. | |
| Atrasentan hydrochloride | Atrasentan hydrochloride (ABT-627 hydrochloride) is a selective endothelin A receptor antagonist with an IC 50 of 0.0551 nM for ET A [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABT-627 hydrochloride; (+)-A 127722 hydrochloride; A-147627 hydrochloride. CAS No. 195733-43-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15403A. | |
| Atrazine | Atrazine, a triazine herbicide, is principally used for control of certain annual broadleaf and grass weeds. Atrazine inhibits photophosphorylation but typically does not result in lethality or permanent cell damage in the short term [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1912-24-9. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-N7091. | |
| Atrazine-d5 | Atrazine-d 5 is deuterium labeled Atrazine. Atrazine is principally used for control of certain annual broadleaf and grass weeds. Atrazine inhibits photophosphorylation but typically does not result in lethality or permanent cell damage in the short term[1]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 163165-75-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N7091S2. | |
| Atrazine (Standard) | Atrazine (Standard) is the analytical standard of Atrazine. This product is intended for research and analytical applications. Atrazine is principally used for control of certain annual broadleaf and grass weeds. Atrazine inhibits photophosphorylation but typically does not result in lethality or permanent cell damage in the short term [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1912-24-9. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-N7091R. | |
| Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse | Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner. Uses: Scientific research. Group: Peptides. Alternative Names: Atrial natriuretic factor (1-28) (rat, mouse). CAS No. 88898-17-3. Pack Sizes: 500 ?g; 1 mg; 5 mg. Product ID: HY-P1236. | |
| Atrimustine | Atrimustine is a conjugate of chlorambucil and β-estradiol benzoate with the antitumor activity. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Bestrabucil; KM2210. CAS No. 75219-46-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101604. | |
| Atropine | Atropine (Tropine tropate) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine inhibits ACh-induced relaxations in human pulmonary veins. Atropine can be used for research of anti-myopia and bradycardia[1][2][3][4]. Uses: Scientific research. Group: Natural products. Alternative Names: Tropine tropate; DL-Hyoscyamine. CAS No. 51-55-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-B1205. | |
| Atropine methyl bromide | Atropine methyl bromide, a muscarinic receptor (mAChR) antagonist, is a quaternary ammonium salt of atropine and a mydriatic for dilation of the pupil during ophthalmic examination. It is introduced for relieving pyloric spasm in infants for its highly polar nature. It penetrates less readily into the central nervous system than atropine [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Methylatropine bromide. CAS No. 2870-71-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112076. | |
| Atropine sulfate | Atropine (Tropine tropate) sulfate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC 50 values of 0.39 and 0.71 nM for Human mAChR M 4 and Chicken mAChR M 4 , respectively. Atropine sulfate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate can be used for research of anti-myopia and bradycardia [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Tropine tropate sulfate; DL-Hyoscyamine sulfate; Sulfatropinol. CAS No. 55-48-1. Pack Sizes: 100 mg. Product ID: HY-B1205A. | |
| Atropine sulfate monohydrate | Atropine (Tropine tropate) sulfate monohydrate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC 50 values of 0.39 and 0.71 nM for Human mAChR M 4 and Chicken mAChR M 4 , respectively. Atropine sulfate monohydrate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate monohydrate can be used for research of anti-myopia and bradycardia [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Tropine tropate sulfate monohydrate; DL-Hyoscyamine sulfate monohydrate. CAS No. 5908-99-6. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-B0394. | |
| Atrosab | Atrosab is a humanized IgG1 antagonistic anti-TNFR1 antibody. Atrosab inhibits TNF-mediated Apoptosis induction and IL-6 and IL-8 production. Atrosab reduces neurological deficits. Atrosab can be used for research of inflammatory disease. The recommend isotype control is Human IgG1 kappa, Isotype Control (HY-P99001)[1][2][3]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 1365659-05-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990008. | |
| ATTO 488 | ATTO 488 is a new type of fluorescent dye with high fluorescence yield, which can be used for most labeling applications, maximum excitation/emission wavelength: 500/520 nm. Uses: Scientific research. Group: Fluorescent dye. CAS No. 923585-42-6. Pack Sizes: 1 mg. Product ID: HY-D2000. | |
| Atumelnant | CRN04894 (compound 17h) is an orally active MC2R antagonist that demonstrates in vivo efficacy in rat model of adrenocorticotropic hormone (ACTH)-stimulated corticosterone secretion[1]. CRN04894 binds to human or rat MC2R with K B values of 0.34 nM and 0.23 nM, respsectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CRN04894. CAS No. 2392970-97-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158081. | |
| Atuveciclib | Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor. Atuveciclib (BAY-1143572) inhibits CDK9 / CycT1 with an IC 50 of 13 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY-1143572. CAS No. 2923012-24-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12871B. | |
| Atuveciclib Racemate | Atuveciclib Racemate (BAY-1143572 Racemate) is the racemate mixture of Atuveciclib. Atuveciclib is a potent and highly selective, oral P-TEFb / CDK9 inhibitor which supresses CDK9 / CycT1 with an IC 50 of 13 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY-1143572 Racemate. CAS No. 1414943-88-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12871. | |
| ATX-0126 | ATX-0126 (ATX 100) is an ionizable lipid based on thiocarbamate. ATX-0126 can be involved in the formation of lipid nanoparticles and is used in research such as nucleic acid delivery[1][2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: ATX 100. CAS No. 2230647-37-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149167. | |
| ATX968 | ATX968 (example 31) is an orally active, potent and selective inhibitor of ATP-dependent RNA helicase A (DHX9), with the EC50 of 0.054 ?M in circBRIP1. ATX968 results in robust and durable tumor growth inhibition or regression in mouse xenograft studies with MSI-H/dMMR colorectal cancer cell lines[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DHX9-IN-2. CAS No. 2973395-71-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156784. | |
| AU-15330 | AU-15330 is a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, SMARCA2 and SMARCA4. AU-15330 induces potent inhibition of tumour growth in xenograft models of prostate cancer and synergizes with the AR antagonist enzalutamide. AU-15330 induces disease remission in castration-resistant prostate cancer (CRPC) models without toxicity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2380274-50-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145388. | |
| AU-24118 | AU-24118 is a selective and orally bioavailable PROTAC degrader of mSWI-SNF ATPases (SMARCA2 and SMARCA4) and PBRM1. AU-24118 integrates a bait moiety binding to the bromodomains of SMARCA2 and SMARCA4, along with a ligand moiety for CRBN ligase. AU-24118 demonstrates tumor regression in prostate cancer model. AU-24118 can be studied to combat prostate cancer. (Pink: PBRM1/SMARCA2,4 ligand (HY-171774); Blue: CRBN ligand (HY-171775))[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3084244-26-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-163410. | |
| Aucubin | Aucubin, an iridoid glucoside, is isolated from Plantago asiatica , Eucommia ulmoides , the leaves of Aucuba japonica and more recently from butterfly larva. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 479-98-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-N0664. | |
| Aucubin (Standard) | Aucubin (Standard) is the analytical standard of Aucubin. This product is intended for research and analytical applications. Aucubin, an iridoid glucoside, is isolated from Plantago asiatica, Eucommia ulmoides, the leaves of Aucuba japonica and more recently from butterfly larva. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 479-98-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0664R. | |
| AUDA | AUDA (compound 43) is a potent soluble epoxide hydrolase (sEH) inhibitor with IC 50 s of 18 and 69 nM for the mouse and human sEH, respectively [1]. AUDA has anti-inflammatory activity [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 479413-70-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-108570. | |
| Augpenin | Augpenin (Ticarcillin-clavulanic acid mixt.) is a mixture of Ticarcillin (HY-139805) and Clavulanic acid (HY-A0256) in a ratio of 15:1 [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Ticarcillin-clavulanic acid mixt. CAS No. 86482-18-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg. Product ID: HY-156264. | |
| Aumitin | Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC 50 s of 0.12 μM and 0.24 μM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 946293-78-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124726. | |
| AUNP-12 | AUNP-12 (NP-12) is a peptide antagonist of the PD-1 signaling pathway , displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. AUNP-12 exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs) [1]. Uses: Scientific research. Group: Peptides. Alternative Names: NP-12. CAS No. 1353563-85-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1812. | |
| Aurachin D | Aurachin D is an antibiotic. Aurachin D inhibits Gram-positive bacteria and a few funguses. Aurachin D blocks NADH oxidation in beef heart submitochondrial particles[1]. Uses: Scientific research. Group: Natural products. CAS No. 108354-13-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-N7151. | |
| Auramine O | Auramine O is a yellow fluorescent dye. Auramine O is used to detect amyloid fibrils. Auramine O promotes lung malignancy. Auramine O is also used to determine algal cell viability and stain acid-fast bacteria [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 2465-27-2. Pack Sizes: 50 g; 100 g. Product ID: HY-D0933. | |
| Auranofin | Auranofin (SKF-39162) is a thioredoxin reductase ( TrxR ) inhibitor with an IC 50 of 0.2 μM. Auranofin exhibits antiviral activity against SARS-CoV21 , with a CC 50 of 4.2?μM for monkey kidney Vero E6 cells. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SKF-39162. CAS No. 34031-32-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1123. | |
| Aurantiamide | Aurantiamide is an orally active constituent of Portulaca oleracea L and has various biological activities, including antioxidant, antiplatelet, anti-inflammatory, and antitumor activities [1]. Uses: Scientific research. Group: Natural products. CAS No. 58115-31-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N2909. | |
| Aurantiamide acetate | Aurantiamide acetate (TMC-58A) is a selective and orally active cathepsin inhibitor isolated from Portulaca oleracea L. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Asperglaucide. CAS No. 56121-42-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N2905. | |
| Auraptene | Auraptene is an orally active geranyloxycoumarin that can be isolated from plants in the Brassicaceae family, antibacterial, anti-pathogen, antioxidant, anti-tumor, and neuroprotective effects. Auraptene plays an important role in the treatment of various chronic diseases such as hypertension and cystic fibrosis [1][2]. Uses: Scientific research. Group: Natural products. CAS No. 495-02-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N2388. | |
| Aureobasidin A | Aureobasidin A (Basifungin) is a cyclic peptide antibiotic with oral activity. Aureobasidin A is an inhibitor of inositol phosphorylated ceramide synthetase AUR1. Aureobasidin A has antifungal and antiparasitic activity [1] [2] [3]. Uses: Scientific research. Group: Peptides. Alternative Names: Basifungin. CAS No. 127785-64-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1975. | |
| Aurintricarboxylic acid | Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs , with IC 50 s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively [1]. Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase [2]. Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis [3]. Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway [4]. Aurintricarboxylic acid also acts as a cystathionine-lyase (CSE) inhibitor with an IC 50 of 0.6 μM [5]. Aurintricarboxylic acid is a modifier of miRNAs that regulate miRNA function, with an IC 50 of 0.47 μM [6]. Uses: Scientific research. Group: Signaling pathways. CAS No. 4431-00-9. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-122575. | |
| Aurkin A | Aurkin A is an allosteric inhibitor for the interaction between Aurora A Kinase (also known also Aurka) and TPX2, through targeting the TPX2 binding sites with Kd of 3.77 ?M. Aurkin A can disrupt polyploidy induced by Alisertib (HY-10971) and increase apoptosis of tumor cells. Aurkin A can be used in research on mitosis and cancer[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1534060-58-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125956. | |
| Aurora kinase inhibitor-2 | Aurora kinase inhibitor-2 is a selective and ATP-competitive Aurora kinase inhibitor with IC 50 s of 310 nM and 240 nM for Aurora A and Aurora B , respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 331770-21-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112355. | |
| Aurothioglucose | Aurothioglucose (Gold thioglucose), containing monovalent gold ion, is a potent active-site inhibitor of TrxR1 (thioredoxin reductase 1), with an IC 50 of 65 nM. Aurothioglucose inhibits the DNA binding of NF-κB in vitro. Aurothioglucose shows anti-HIV and anti-rheumatic activities [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Gold thioglucose. CAS No. 12192-57-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-A0068. | |
| Aurothiomalate sodium | Aurothiomalate sodium is a potent and selective oncogenic PKC Ι signaling inhibitor. Aurothiomalate sodium inhibits tumor cell proliferation and not cell apoptosis. Aurothiomalate sodium is a potent thioredoxin reductase (TrxR) inhibitor. Aurothiomalate sodium, an anti-rheumatoid agent, exhibits potent anti-tumor activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 12244-57-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106381. | |
| AUT1 | AUT1 is a recombinant human Kv3 channel modulator. AUT1 modulates Kv3.1b and Kv3.2a channels in human recombinant with pEC50 values of 5.33 and 5.31 ?M, respectively. AUT1 can be used for the research of disorders associated with dysfunction of inhibitory feedback in corticolimbic circuits, such as schizophrenia[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1311136-84-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-117639. | |
| Autocamtide 2 | Autocamtide 2 is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II ( CaMKII ). It can be used in the CaMKII activity assay. Uses: Scientific research. Group: Peptides. Alternative Names: Autocamtide II. CAS No. 129198-88-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P0225. | |
| Autophagy inducer 7 | Autophagy inducer 7 (Compound SSA) is an Autophagy and Apoptosis inducer. Autophagy inducer 7 activates autophagy by inhibiting Akt/mTOR signaling and the expression of downstream proteins. Autophagy inducer 7 suppresses DNA synthesis and causes a G0-G1 cell-cycle arrest. Autophagy inducer 7 inhibits tumor cell growth [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 944159-20-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-171047. | |
| Auxinole | Auxinole is a potent auxin antagonist of TIR1/AFB receptors, binding TIR1 to block the formation of the TIR1-IAA-Aux/IAA complex and so inhibits auxin-responsive gene expression. Uses: Scientific research. Group: Signaling pathways. CAS No. 86445-22-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-111444. | |
| AUZ 454 | AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd of 8.2 nM. AUZ 454 (K03861) inhibits CDK2 activity by competing with binding of activating cyclins. Uses: Scientific research. Group: Signaling pathways. Alternative Names: K03861. CAS No. 853299-07-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15004. | |
| AV023 | AV023 is a potent inhibitor of ANKRD22. AV023 promotes the expansion of gastrointestinal mucosal epithelial stem cells and indirectly activates the Wnt classical pathway, which helps the recovery of damaged gastrointestinal mucosal tissues in the body (extracted from patent CN111205231B) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1107710-62-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145686. | |
| AV123 | AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor ( IC 50 =12.12 μM). AV123 blocks the TNF-α-induced necroptotic ( EC 50 =1.7 μM) but not the apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart and kidney, inflammatory diseases, neurodegenerative diseases and infectious diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 233605-81-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151369. | |
| AV5124 | AV5124, a prodrug of AV5116, is an orally active influenza virus cap-dependent endonuclease (CEN) endonuclease inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2417851-93-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-164927. | |
| Avacopan | Avacopan (CCX168) is a potent, selective and orally available complement 5a receptor ( C5aR ) inhibitor with an IC 50 of 0.1 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CCX168. CAS No. 1346623-17-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17627. | |
| Avadomide | Avadomide is an orally active cereblon modulator. Avadomide modulates cereblon E3 ligase activity, inhibits NF-κB pathway, arrests the cell cycle at G1 phase, and thus induces apoptosis in cancer cell PDAC. Avadomide exhibits potent antitumor and immunomodulatory activities [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CC 122. CAS No. 1015474-32-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100507. | |
| Avagacestat | Avagacestat (BMS-708163) is a potent inhibitor of γ-secretase , with IC 50 s of 0.27 nM and 0.30 nM for Aβ42 and Aβ40 inhibition; Avagacestat (BMS-708163) also inhibits NICD (Notch IntraCellular Domain) with IC 50 of 0.84 nM and shows weak inhibition of CYP2C19, with IC 50 of 20 μM. Avagacestat can be used for Alzheimer disease research. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-708163. CAS No. 1146699-66-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50845. | |
| Avanafil | Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC 50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: TA1790. CAS No. 330784-47-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-18252. | |
| Avapritinib | Avapritinib (BLU-285) is a highly potent, selective, and orally active KIT and PDGFRA activation loop mutant kinases inhibitor with IC 50 s of 0.27 and 0.24 nM for KIT D816V and PDGFRA D842V , respectively. Avapritinib (BLU-285) binds the active conformation of the kinase and shows antitumor activity. Avapritinib (BLU-285) attenuates the transport function of both ABCB1 and ABCG2 [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BLU-285. CAS No. 1703793-34-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101561. | |
| Avasimibe | Avasimibe (CI-1011; PD-148515) is an orally active acyl coenzyme A-cholesterol acyltransferase (ACAT; also called SOAT)) inhibitor with IC50s of 24 and 9.2 μM for ACAT1 and ACAT2, respectively[1]. Avasimibe can be used for the research of prostate cancer[2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CI-1011; PD-148515. CAS No. 166518-60-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13215. | |
| Avasopasem manganese | Avasopasem manganese (GC4419; M-40419) is a potent superoxide dismutase mimetic that rapidly and specifically converts O 2 *- to hydrogen peroxide (H 2 O 2 ), arresting the initiation of this cascade. Avasopasem manganese can be used for the research of severe oral mucositis (SOM) and cancer [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GC-4419; M-40419. CAS No. 435327-40-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109110. | |
| Avatrombopag | Avatrombopag (AKR-501) is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist ( EC 50 =3.3 nM). Avatrombopag mimics the biological activities of TPO. Avatrombopag increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AKR-501; E5501; YM477. CAS No. 570406-98-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13463. | |
| Avatrombopag hydrochloride | Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist ( EC 50 =3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AKR-501 hydrochloride; E5501 hydrochloride; YM477 hydrochloride. CAS No. 570403-17-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13463B. | |
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