MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Closantel | Closantel is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel is a potent and highly specific Onchocerca volvulus chitinase ( OvCHT1 ) inhibitor with an IC 50 of 1.6 μM and a K i of 468 nM. Closantel inhibits the O. volvulus L3 to L4 molt of developing [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 57808-65-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-17596. |  |
| Closantel sodium | Closantel sodium is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel sodium is a potent and highly specific Onchocerca volvulus chitinase ( OvCHT1 ) inhibitor with an IC 50 of 1.6 μM and a K i of 468 nM. Closantel sodium inhibits the O. volvulus L3 to L4 molt of developing [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 61438-64-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-17596A. | |
| Clostripain | Clostripain (Clostridiopeptidase B) is a proteolytic enzyme isolated from Clostridium histolyticum with esterase, amidase and protease activities and is a highly specific carboxypeptide targeting arginine key protease [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Clostridiopeptidase B. CAS No. 9028-00-6. Pack Sizes: 1 mg. Product ID: HY-P2895. | |
| Clothianidin | Clothianidin is a neonicotinoid insecticide. Clothianidin shows excellent long-term control effect in small doses against various insect pests such as Coleoptera, Thysanoptera, Lepidoptera, Diptera, Homoptera, Heteroptera, Orthoptera and Isoptera families. Clothianidin has various application methods and high safety for crops [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 210880-92-5. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-133167. | |
| Clothiapine | Clothiapine, an atypical antipsychotic agent, shares with clozapine its strong antiserotonergic properties [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2058-52-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-117083. | |
| Clothixamide | Clothixamide is a thiazide derivative. It is used to treat psychiatric disorders. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Clotixamide. CAS No. 4177-58-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00021. | |
| Clotrimazole | Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor. Clotrimazole has antibacterial activity. Uses: Scientific research. Group: Signaling pathways. CAS No. 23593-75-1. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-10882. | |
| Clove oil | Clove oil is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Clove leaf oil,rectified. CAS No. 8000-34-8. Pack Sizes: 5 mL; 10 mL. Product ID: HY-N1953. | |
| Cloxacillin sodium | Cloxacillin sodium is an orally active antibacterial agent and β-lactamase inhibitor with an IC 50 of 0.04 μM. Cloxacillin sodium can suppress the S. aureus -induced inflammatory response by inhibiting the activation of MAPKs , NF-?B and NLRP3 -related proteins [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 642-78-4. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B0466B. | |
| Cloxacillin sodium monohydrate | Cloxacillin sodium monohydrate is an orally active antibacterial agent and β-lactamase inhibitor with an IC 50 of 0.04 μM. Cloxacillin sodium monohydrate can suppress the S. aureus -induced inflammatory response by inhibiting the activation of MAPKs , NF-?B and NLRP3 -related proteins [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 7081-44-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0466. | |
| Clozapine | Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a K i of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with K i s of 9.5 nM and 4 nM, respectively [1] [2] [3]. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor ( EC 50 =11 nM) [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HF 1854. CAS No. 5786-21-0. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 250 mg. Product ID: HY-14539. | |
| Clozapine-d4 | Clozapine-d 4 is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors[1][2][3][4][5]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: HF 1854-d4. CAS No. 204395-52-8. Pack Sizes: 1 mg. Product ID: HY-14539S2. | |
| Clozapine N-oxide | Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can cross the blood-brain barrier [1] [2] [3] [4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor ( EC 50 =11 nM) agonist [5] [6]. Uses: Scientific research. Group: Signaling pathways. CAS No. 34233-69-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17366. | |
| Clozapine N-oxide dihydrochloride | Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride can cross the blood-brain barrier [1] [2] [3] [4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor ( EC 50 =11 nM) agonist [5] [6]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2250025-93-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17366A. | |
| Clozapine (Standard) | Clozapine (Standard) is the analytical standard of Clozapine. This product is intended for research and analytical applications. Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a K i of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with K i s of 9.5 nM and 4 nM, respectively [1] [2] [3]. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor ( EC 50 =11 nM) [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HF 1854 (Standard). CAS No. 5786-21-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14539R. | |
| CLP257 | CLP257 is a selective K+-Cl cotransporter KCC2 activator with an EC50 of 616 nM. CLP257 is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 restores impaired Cl transport in neurons with diminished KCC2 activity. CLP257 alleviates hypersensitivity in rats with neuropathic pain. CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1181081-71-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110143. | |
| CLP290 | CLP290 is an orally available activator of the neuron-specific K+-Cl- cotransporter KCC2, displays potential for treatment of a wide range of neurological and psychiatric indications. CLP290 can significantly lower blood arginine-vasopressin (AVP) and glucose levels in STZ (HY-13753) rats[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1181083-81-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103023. | |
| Cl-PEG4-acid | Cl-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 158553-98-1. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-W096129. | |
| CLZ-8 | CLZ-8 (Compound 8) is an orally active Mcl-1-PUMA interface inhibitor, with a K i of 0.3 μM. CLZ-8 exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 678158-55-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122627. | |
| CM03 | CM03 is a potent DNA G-quadruplexes (G4s) ligand. CM03 can stabilise G4s, downregulating more G4-containing genes as well as increasing incidence of double-strand break events (DSBs) due to torsional strain on DNA and chromatin structure. CM03 has selective potency for pancreatic cancer cells [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2101208-44-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121862. | |
| CM-24 | CM-24 is a humanized antibody expressed in CHO cells, targeting CEACAM1/CD66a. The predicted molecular weight (MW) of CM-24 is 145 kDa. The isotype control for CM-24 can refer to Human IgG1 kappa, Isotype Control (HY-P99001). Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 1783801-93-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990569. | |
| CM-272 | CM-272 is a first-in-class, potent, selective, substrate-competitive and reversible dual G9a/DNA methyltransferases (DNMTs) inhibitor with antitumor activities. CM-272 inhibits G9a, DNMT1, DNMT3A, DNMT3B and GLP with IC50s of 8 nM, 382 nM, 85 nM, 1200 nM and 2 nM, respectively. CM-272 inhibits cell proliferation and promotes apoptosis, inducing IFN-stimulated genes and immunogenic cell death[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1846570-31-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101925. | |
| CM398 | CM398 is a highly selective, orally active sigma-2 receptor ligand ( K i =0.43 nM), with high sigma-1/sigma-2 selectivity rato (1000-fold). CM398 shows notable affinity for dopamine (K i =32.90 nM) and serotonin transporters (K i =244.2 nM). CM398 shows promising anti-inflammatory analgesic effects in the formalin model of inflammatory pain in mice [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1121931-70-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145628. | |
| CMF019 | CMF019 is an orally active, potent and small molecule agonist at Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ with pKi values of 8.58, 8.49 and 8.71 for human, rat, and mouse, respectively. CMF019 mimics the beneficial cardiovascular actions of apelin in rodents[1]. Apelin receptor (APJ) is a G protein-coupled receptor (GPCR) activated by the endogenous peptide apelin. CMF019 is promising for research of chronic diseases, such as, pulmonary arterial hypertension[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1586787-08-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103080. | |
| CM-H2DCFDA | CM-H2DCFDA is a derivative of H2DCFDA (HY-D0940). CM-H2DCFDA can be used to determine cellular oxidant levels (Ex/Em: 495/530 nm). CM-H2DCFDA is light-sensitive[1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 850013-49-9. Pack Sizes: 50 ?g. Product ID: HY-D1713. | |
| CMK | CMK is a RSK2 kinase inhibitor which exhibits similar potency but less chemical stability compared with FMK. Uses: Scientific research. Group: Signaling pathways. CAS No. 821794-90-5. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-52101. | |
| CMLD-2 | CMLD-2, an inhibitor of HuR-ARE interaction, competitively binds HuR protein disrupting its interaction with adenine-uridine rich elements (ARE)-containing mRNAs (Ki=350 nM). CMLD-2 induces apoptosis exhibits antitumor activity in different cancer cells as colon, pancreatic, thyroid and lung cancer cell lines. Hu antigen R (HuR) is an RNA binding protein, can regulate target mRNAs stability and translation[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 958843-91-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-124828. | |
| CMP-5 | CMP-5 is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 prevents Epstein-Barr virus (EBV)-driven B-lymphocyte transformation but leaving normal B cells unaffected [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 880813-42-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120137. | |
| CMPD101 | CMPD101 is a potent, highly selective and membrane-permeable small-molecule inhibitor of GRK2/3 with IC50 of 18 nM and 5.4 nM, respectively. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKC? with IC50s of 3.1 ?M , 2.3 ?M, 1.4 ?M and 8.1 ?M, respectively. CMPD101 can be used for the study of heart failure[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 865608-11-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103045. | |
| CMPD-39 | CMPD-39 is a selective non-covalent inhibitor of the ubiquitin-specific protease USP30 (IC50=~20 nM), with high selectivity over other DUB family members (1-100 ?M). CMPD-39 inhibits the deubiquitinating activity of USP30, enhances the ubiquitination of mitochondrial proteins TOMM20 and SYNJ2BP; thus, CMPD-39 promotes phosphoubuitin accumulation, thereby accelerating mitochondrial autophagy (mitophagy) and peroxisomal autophagy (pexophagy). CMPD-39 significantly restores impaired mitochondrial function in dopaminergic neurons derived from Parkinson's disease patients[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2242582-40-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141659. | |
| CMPF | CMPF can be found in trace constituent of urine and blood. CMPF is a biomarker of type 2 diabetes. CMPF can act on the β cell and induces impaired mitochondrial function. CMPF decreases glucose-induced ATP accumulation, and induces oxidative stress. CMPF reverses hepatic lipid accumulation and improves insulin sensitivity in obese mice [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 86879-39-2. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-129297. | |
| CMP-Sialic acid sodium salt | CMP-Sialic acid (CMP-Neu5Ac) sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases. CMP-Sialic acid sodium salt is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates [1]. Uses: Scientific research. Group: Natural products. Alternative Names: CMP-Neu5Ac sodium salt. CAS No. 1007117-62-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-112942A. | |
| c-Myc Peptide TFA | c-Myc Peptide (TFA) is a synthetic peptide corresponding to the C-terminal amino acids (410-419) of human c-myc protein, and participates in regulation of growth-related gene transcription. Uses: Scientific research. Group: Peptides. CAS No. 2918768-02-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P0312. | |
| CNQX | CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 ?M and 1.5 ?M, respectively. CNQX is a competitive non-NMDA receptor antagonist[1]. CNQX blocks the expression of fear-potentiated startle in rats[5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FG9065. CAS No. 115066-14-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15066. | |
| CNQX disodium | CNQX disodium (FG9065 disodium) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 ?M and 1.5 ?M, respectively. CNQX disodium is a competitive non-NMDA receptor antagonist[1]. CNQX disodium blocks the expression of fear-potentiated startle in rats[5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FG9065 disodium. CAS No. 479347-85-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15066A. | |
| CNX-500 | CNX-500 is a probe consisting of a covalent Btk inhibitor (CC-292) chemically linked to biotin. CNX-500 retains inhibitory activity against Btk ( IC 50 of 0.5 nM) and the ability to form a covalent bond with Btk. CNX-500 has low inhibitory effects on kinase epidermal growth factor receptor, and upstream Src-family kinases including Syk and Lyn [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1202758-21-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-100338. | |
| Co 101244 hydrochloride | Co 101244 (PD 174494) hydrochloride is a NR2B-containing NMDA receptor antagonist [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PD 174494 hydrochloride. CAS No. 193356-17-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107706. | |
| COB-187 | COB-187 is a potent, ATP-competitive and selective inhibitor of GSK-3&beta. COB-187 inhibits GSK-3 through a reversible and Cysteine (Cys)-199-dependent mechanism. COB-187 inhibits LPS induced cytokine production and SARS-CoV-2 spike protein-induced CXCL10 production [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1862177-86-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162675. | |
| Cobalt(II) TPP | 5,10,15,20-Tetraphenyl-21H,23H-porphine cobalt(II), commonly known as CoTPP or cobalt porphyrin, is a coordination compound. 5,10,15,20-Tetraphenyl-21H,23H-porphine cobalt(II) is widely used in various fields such as catalysis, sensing, and organic electronics because of its unique electronic and optical properties. An efficient catalyst for reactions including oxidation, reduction, and CH bond activation, moreover, it has been used as a fluorescent probe for detecting oxygen content in biological systems and as an active material in organic solar cells. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 14172-90-8. Pack Sizes: 100 mg; 500 mg; 1 g. Product ID: HY-W073013. | |
| Cobalt phthalocyanine | Cobalt phthalocyanine is a catalyst of redox reaction, catalyzes aerobic regenerations of aldehydes and ketones from aldoximes and ketoximes. Cobalt phthalocyanine can be used in the development of electrocatalysts [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cobalt(II) phthalocyanine; Cobaltous phthalocyanine; Phthalocyanine cobalt complex. CAS No. 3317-67-7. Pack Sizes: 500 mg; 1 g. Product ID: HY-18761. | |
| Cobicistat | Cobicistat is a potent and selective inhibitor of cytochrome P450 3A (CYP3A) enzymes with IC 50 s of 30-285 nM. Cobicistat is a pharmacokinetic enhancer which increases the overall absorption of several HIV medications. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GS-9350. CAS No. 1004316-88-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10493. | |
| Cobimetinib | Cobimetinib (GDC-0973, RG7420) is a potent, selective and oral MEK1 inhibitor with an IC 50 of 4.2 nM for MEK1. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GDC-0973; XL518. CAS No. 934660-93-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13064. | |
| Cobimetinib hemifumarate | Cobimetinib hemifumarate is a novel selective MEK1 inhibitor, and the IC 50 value against MEK1 is 4.2 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GDC-0973 hemifumarate; XL-518 hemifumarate. CAS No. 1369665-02-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13064A. | |
| Cobimetinib racemate | Cobimetinib racemate (GDC-0973 racemate; XL518 racemate) is the racemate of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GDC-0973 racemate; XL518 racemate. CAS No. 934662-91-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13078. | |
| Coblopasvir dihydrochloride | Coblopasvir (KW-136) dihydrochloride is a pangenotypic non-structural protein 5A (NS5A) inhibitor. Coblopasvir dihydrochloride can be used for research of chronic hepatitis C virus infection [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KW-136 dihydrochloride. CAS No. 1966138-53-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117411A. | |
| Cobolimab | Cobolimab (TSR-022) is an anti- TIM-3 monoclonal antibody. Cobolimab mediates the internalization of TIM3 with an IC 50 value of 0.4464 nM. Cobolimab has potential application in solid tumors and non-small cell lung cancer (NSCLC) [1] [2] [3]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: TSR-022; GSK4069889. CAS No. 2022215-65-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99827. | |
| Cobra Venom Factor | Cobra venom factor (CVF) is the complement-activating protein from cobra venom. CVF is a three-chain protein that functionally resembles C3b, the activated form of complement component C3. Cobra Venom Factor can be used for the research of the functions of complement in host defense and immune response as well as in the pathogenesis of diseases[1][2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: CVF. Pack Sizes: 500 ?g; 1 mg. Product ID: HY-NP004. | |
| (+)-Coclaurine hydrochloride | (+)-Coclaurine ((+)-(R)-Coclaurine) hydrochloride, benzyltetrahydroisoquinoline alkaloid isolated from a variety of plant sources. (+)-Coclaurine hydrochloride has anti-aging activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (+)-(R)-Coclaurine hydrochloride; (R)-Coclaurine hydrochloride; d-Coclaurine hydrochloride. CAS No. 19894-19-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N2550A. | |
| Codrituzumab | Codrituzumab (GC33) is a humanized monoclonal antibody targeting human GPC3 (glypican-3), with high affinity (Kd of 0.673 nM). GPC3 is an oncofetal protein expressed on the cell surface of hepatocellular carcinoma (HCC). Codrituzumab induces antibody-dependent cellular cytotoxicity (ADCC) and inhibits tumor growth[1][2][3][4]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: GC33; RO5137382. CAS No. 1365267-33-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99013. | |
| Coelenteramine 400a | Coelenteramine 400a (Coelenterazine 400a), a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a, RLuc can emit blue light at 395 nm[1][2]. Coelenterazine 400a will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenterazine 400a provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET)[3]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Coelenterazine 400a; Bisdeoxycoelenterazine. CAS No. 70217-82-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-118462. | |
| Coelenterazine | Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate coelenterazine has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite [1] [2] [3]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 55779-48-1. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18743. | |
| Coelenterazine h | Coelenterazine h (2-Deoxycoelenterazine), a coelenterazine derivative, is a luminescent substrate for RLuc8. Coelenterazine h is more sensitive to Ca 2+ , thus providing a valuable tool for measuring small changes in Ca 2+ concentrations [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2-Deoxycoelenterazine; CLZN-h. CAS No. 50909-86-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-D1024. | |
| Coenzyme A | Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids [1]. Uses: Scientific research. Group: Natural products. CAS No. 85-61-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-128851. | |
| Coenzyme A sodium | Coenzyme A (CoASH) sodium is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 55672-92-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-128851B. | |
| Coenzyme A trilithium | Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 18439-24-2. Pack Sizes: 10 mg. Product ID: HY-128851A. | |
| Coenzyme FO | Coenzyme FO, a deazaflavin chromophore, acts as an important hydride acceptor/donor in the central methanogenic pathway [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 37333-48-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136497. | |
| Coenzyme Q0 | Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy , suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling [1] [2] [3]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: CoQ0. CAS No. 605-94-7. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W016412. | |
| Coenzyme Q10 | Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent. Uses: Scientific research. Group: Natural products. Alternative Names: CoQ10; Ubiquinone-10; Ubidecarenone. CAS No. 303-98-0. Pack Sizes: 100 mg; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-N0111. | |
| Coenzyme Q10 (Standard) | Coenzyme Q10 (Standard) is the analytical standard of Coenzyme Q10. This product is intended for research and analytical applications. Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent. Uses: Scientific research. Group: Natural products. CAS No. 303-98-0. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0111R. | |
| Coenzyme Q9 | Coenzyme Q9 (Ubiquinone Q9), the major form of ubiquinone in rodents, is an amphipathic molecular component of the electron transport chain that functions as an endogenous antioxidant. Coenzyme Q9 attenuates the diabetes-induced decreases in antioxidant defense mechanisms. Coenzyme Q9 improves left ventricular performance and reduces myocardial infarct size and cardiomyocyte apoptosis[1][2]. Uses: Scientific research. Group: Natural products. Alternative Names: Ubiquinone Q9; CoQ9; Ubiquinone 9. CAS No. 303-97-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-101415. | |
| Cofetuzumab | Cofetuzumab (PF-06523435) is a humanized IgG1-κ monoclonal antibody targeting PTK7. The expression system of Cofetuzumab is usually CHO (Chinese Hamster Ovary) cells [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: PF-06523435; hu24. CAS No. 1869928-62-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99828. | |
| Cofetuzumab pelidotin | Cofetuzumab pelidotin (PF-06647020) is a PTK7 -targeting ADC comprising a humanized anti-PTK7 mAb (hu6M024, IgG1) joined to an auristatin microtubule inhibitor payload, auristatin-0101 (Aur0101; HY-12522), by a cleavable valine-citrulline (vc)-based linker. Cofetuzumab pelidotin has a DAR of 4. Cofetuzumab pelidotin binds to cell-surface PTK7 with an EC 50 of 1153 pM by flow cytometry. Cofetuzumab pelidotin has the potential for solid tumors research [1] [2] [3]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: PF-06647020; ABBV-647; h6M24-vc0101. CAS No. 1869937-48-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99829. | |
| COG1410 | COG1410 is an apolipoprotein E-derived peptide and an apoptosis inhibitor. COG1410 exerts neuroprotective and antiinflammatory effects in a murine model of traumatic brain injury (TBI). COG1410 can be used for the research of neurological disease[1][2]. Uses: Scientific research. Group: Peptides. CAS No. 878009-24-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2136. | |
| COH1 | COH1 is a ribonucleotide reductase ( RR ) inhibitor. COH1 can be used in research into cancer, mitochondrial diseases, and neurodegenerative diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 20217-22-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149439. | |
| COH29 | COH29 (RNR Inhibitor COH29) is a potent ribonucleotide reductase (RNR) inhibitor with anticancer activity. COH29 inhibits ? and ? subunit of RNR with IC50s of 16 ?M. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RNR Inhibitor COH29. CAS No. 1190932-38-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19931. | |
| COH34 | COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 ?M), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 906439-72-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-128760. | |
| Co(III) protoporphyrin IX chloride | Co(III) Protoporphyrin IX chloride (CoPP) is an effective HO-1inducer. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Protoporphyrin IX cobaltic chloride. CAS No. 102601-60-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W250116. | |
| Col003 | Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen binding site on Hsp47 (IC50=1.8 ?M). Col003 discourages the interaction of Hsp47 with collagen and inhibits collagen secretion by destabilizing the collagen triple helix. Col003 can be used for the investigation of fibrosis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 328565-16-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124817. | |
| Colchicine | Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC 50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 64-86-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-16569. | |
| Colchicoside | Colchicoside is a bioactive tropolone alkaloid with anti-leishmanial and anti-leishmanial activities [1]. Uses: Scientific research. Group: Natural products. CAS No. 477-29-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-131300. | |
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