MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| CPS2 | CPS2 is a first-in-class, highly potent, selective and irreversible PROTAC CDK2 degrader ( IC 50 = 24 nM). CPS2 can be used for the research of acute myeloid leukemia [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2756741-90-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141680. |  |
| (±)-CPSI-1306 | (±)-CPSI-1306 is an orally available antagonist of macrophage migration inhibitory factor (MIF). Uses: Scientific research. Group: Signaling pathways. CAS No. 1309793-47-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110095. | |
| CPTH2 | CPTH2 is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B)[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 357649-93-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-W013274. | |
| CPUY192018 | CPUY192018 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, with an IC50 of 0.63 μM. CPUY192018 exhibits anti-inflammatory and antioxidant activities. CPUY192018 can activate the Nrf2-dependent antioxidant pathway and inhibit the NF-?B-related inflammatory response. CPUY192018 can be used in the research of inflammation-related diseases[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1567836-15-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120371. | |
| CPYPP | CPYPP is a DOCK2-Rac1 interaction inhibitor. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1 in a dose-dependent manner with an IC50 of 22.8 μM. CPYPP also inhibits DOCK180 and DOCK5 and less inhibits DOCK9[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 310460-39-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110100. | |
| CR-1-31-B | CR-1-31-B is a synthetic rocaglate and a potent eIF4A inhibitor. CR-1-31-B exhibits powerful inhibitory effects over eIF4A by perturbing the interaction between eIF4A and RNA, sequentially impeding initiation during protein synthesis. CR-1-31-B perturbs association of Plasmodium falciparum eIF4A (PfeIF4A) with RNA. CR-1-31-B induces apoptosis of neuroblastoma and gallbladder cancer cells[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1352914-52-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-136453. | |
| CRAMP (mouse) | CRAMP (mouse) is an antimicrobial peptide. CRAMP (mouse) can be used for the research of biofilm-associated infections [1]. Uses: Scientific research. Group: Peptides. CAS No. 376364-36-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P4855. | |
| CRANAD-2 | CRANAD-2 is a near-infrared (NIR) Aβ plaque-specific fluorescent probe. CRANAD 2 penetrates the blood brain barrier and has a high affinity for Aβ aggregates with a K d of 38 nM [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1193447-34-5. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-103242. | |
| Creatinase, microorganism | Creatine amidinohydrolase, microorganism is a hydrolytic enzyme that catalyzes the hydrolysis of creatine into creatinine and urea, playing a crucial role in the measurement of creatinine concentration. Creatine amidinohydrolase, microorganism can be used in the development of biosensors for measuring serum creatinine levels [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Creatine amidinohydrolase, microorganism. CAS No. 37340-58-2. Pack Sizes: 1 KU; 5 KU. Product ID: HY-P2893B. | |
| Creatine | Creatine, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain. Uses: Scientific research. Group: Natural products. CAS No. 57-00-1. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g. Product ID: HY-W010388. | |
| Creatine-d3 | Creatine-d3 is the deuterium labeled Creatine (HY-W010388)[1]. Creatine, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain[2]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 143827-19-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-W010388S1. | |
| Creatine-d5 monohydrate | Creatine-d5 (monohydrate) is the deuterium labeled Creatine monohydrate. Creatine monohydrate, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain[1]. Uses: Scientific research. Group: Isotope-labeled compounds. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-W017462S. | |
| Creatine monohydrate | Creatine monohydrate, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain [1]. Uses: Scientific research. Group: Natural products. CAS No. 6020-87-7. Pack Sizes: 100 mg. Product ID: HY-W017462. | |
| Creatininase, Microorganism | Creatininase, Microorganism (Creatinine amidohydrolase; CAH), namely creatinine amidohydrolase, from Pseudomonas putida , is a homohexameric enzyme commonly used in biochemical research. Creatininase acts on carbon-nitrogen bonds other than peptide bonds, and can catalyze the hydrolysis of creatinine to creatine, which can then be metabolized by creatinase to urea and sarcosine [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Creatinine amidohydrolase; CAH. CAS No. 9025-13-2. Pack Sizes: 1 KU. Product ID: HY-P2838. | |
| Creatinine | Creatinine (NSC13123) is a breakdown product of creatine phosphate in muscles. Uses: Scientific research. Group: Natural products. Alternative Names: NSC13123. CAS No. 60-27-5. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-B0504. | |
| Creatinine-d3 | Creatinine-d 3 is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle [1]. Uses: Scientific research. Group: Natural products. Alternative Names: NSC13123-d3. CAS No. 143827-20-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0504S. | |
| Creatinine-d5 | Creatinine-d5 is the deuterium labeled Creatinine. Creatinine (NSC13123) is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body[1][2][3]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: NSC13123-d5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0504S2. | |
| Creatinine (Standard) | Creatinine (Standard) is the analytical standard of Creatinine. This product is intended for research and analytical applications. Creatinine (NSC13123) is a breakdown product of creatine phosphate in muscles. Uses: Scientific research. Group: Natural products. CAS No. 60-27-5. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0504R. | |
| Crebanine | Crebanine, an alkaloid from Stephania venosa , induces G1 arrest and apoptosis in human cancer cells. Crebanine exhibits anti-inflammatory activity via suppressing MAPKs and Akt signaling. Crebanine also possesses antiarrhythmic effect [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 25127-29-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N2255. | |
| CREBtide | CREBtide is a CREB (cAMP response element binding protein)-like peptide. CREBtide, a synthetic 13 amino acid peptide, has been reported as a PKA and PKC substrate. Uses: Scientific research. Group: Peptides. CAS No. 149155-45-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1595. | |
| Crelosidenib | Mutant IDH1-IN-6 is a potent, selective and orally active mutant isocitrate dehydrogenase (IDH) inhibitor with IC 50 s of 6.27 nM, 3.71 nM, 36.9 nM and 11.5 nM for IDH1 R132H , IDH1 R132C , IDH2 R140Q and IDH2 R172K mutant enzymes , respectively. Mutant IDH1-IN-6 is less active at inhibiting the IDH wild-type enzymes [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY3410738; Mutant IDH1-IN-6. CAS No. 2230263-60-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-131312. | |
| Cremophor EL-36 | Cremophor EL-36 is a nonionic surfactant, mainly used as a solubilizing carrier for poorly soluble Paclitaxel (HY-B0015). The functions of Cremophor EL-36 include: 1) affecting pharmacokinetics by encapsulating drugs in micelles, changing drug distribution and clearance; 2) activating the complement system and inducing allergic reactions; 3) binding to lipoproteins and interfering with lipid metabolism. Cremophor EL-36 increases drug solubility through micellization, while mediating toxicity through complement activation and lipoprotein interactions[1][2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Polyoxyethylene(36) Castor Oil; PEG-36 Castor Oil. CAS No. 61791-12-6. Pack Sizes: 50 g; 100 g. Product ID: HY-401424. | |
| Cremophor EL-40 | Cremophor EL-40, a polyoxyethylene castor oil derivative, is a nonionic surfactant. Cremophor EL-40 is widely employed to improve dissolution and delivery of agents[1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Polyoxyethylene(40) Castor Oil; PEG-40 Castor Oil. CAS No. 61791-12-6. Pack Sizes: 100 mL. Product ID: HY-Y1890. | |
| Crenezumab | Crenezumab (MABT 5102A; RG 7412) is a fully humanized anti-Aβ monoclonal antibody that binds multiple forms of Aβ, such as soluble, oligomeric and fibrillar, for use in Alzheimer's disease research [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MABT 5102A; RG 7412. CAS No. 1095207-05-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99835. | |
| Crenigacestat | Crenigacestat (LY3039478) is an orally active Notch and γ-secretase inhibitor, with an IC 50 of 1 nM in most of the tumor cell lines tested [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY3039478. CAS No. 1421438-81-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12449. | |
| Crenolanib | Crenolanib is a potent and selective inhibitor of wild-type and mutant isoforms of the class III receptor tyrosine kinases FLT3 and PDGFRα/β with K d s of 0.74 nM and 2.1 nM/3.2 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CP-868596. CAS No. 670220-88-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13223. | |
| Creosol | Creosol (2-Methoxy-4-methylphenol) is an endogenous metabolite that acts as an important chemical intermediate and potential biofuel mainly derived from lignocellulosic biomass. Creosol is blood brain barrier penetrable [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: 2-Methoxy-4-methylphenol. CAS No. 93-51-6. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-W040971. | |
| Cresyl Violet acetate | Cresyl Violet acetate is a dye, which can be used to stain neurons. Uses: Scientific research. Group: Fluorescent dye. CAS No. 10510-54-0. Pack Sizes: 100 mg. Product ID: HY-101888. | |
| Crinecerfont hydrochloride | Crinecerfont (SSR-125543) hydrochloride is a potent, orally active, non-peptide CRF1 receptor antagonist. Crinecerfont can be used for Classic congenital adrenal hyperplasia (CAH) research [1]. Crinecerfont (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SSR-125543 hydrochloride. CAS No. 321839-75-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-106203A. | |
| Crisaborole | Crisaborole (AN-2728) is a potent inhibitor of PDE4 and cytokine release; inhibit PDE4 with an IC 50 of 0.49 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AN-2728; PF-06930164. CAS No. 906673-24-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10978. | |
| Crisaborole (Standard) | Crisaborole (Standard) is the analytical standard of Crisaborole. This product is intended for research and analytical applications. Crisaborole (AN-2728) is a potent inhibitor of PDE4 and cytokine release; inhibit PDE4 with an IC 50 of 0.49 μM. Uses: Scientific research. Group: Signaling pathways. CAS No. 906673-24-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10978R. | |
| Crisdesalazine | Crisdesalazine (AAD-2004) is an anti-inflammatory agent that simultaneously blocks inflammation mediated by free radicals and prostaglandin E2 (PGE2). Crisdesalazine (AAD-2004) can be used to study neurodegeneration in amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AAD-2004. CAS No. 927685-43-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-105005. | |
| Crizanlizumab | Crizanlizumab is an anti- P-selectin monoclonal antibody. Crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand 1 (PSGL-1). Crizanlizumab prevents vaso-occlusive crises (VOCs) and can be used for research of sickle cell disease [1] [2] [3]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 1690318-25-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9987. | |
| Crizotinib | Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC 50 s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC 50 s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-02341066. CAS No. 877399-52-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-50878. | |
| Crizotinib hydrochloride | Crizotinib hydrochloride (PF-02341066 hydrochloride) is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor with IC 50 s of 20 and 8 nM, respectively. Crizotinib hydrochloride (PF-02341066 hydrochloride) inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC 50 s of 24 and 11 nM in cell-based assays, respectively. It is also a ROS proto-oncogene 1 (ROS1) inhibitor. Crizotinib hydrochloride (PF-02341066 hydrochloride) has effective tumor growth inhibition [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-02341066 hydrochloride. CAS No. 1415560-69-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-50878A. | |
| Crocetin | Crocetin (Transcrocetin), extracted from saffron ( Crocus sativus L. ), acts as an NMDA receptor antagonist with high affinity [1]. Crocetin is capable of crossing the blood-brain barrier and reach the central nervous system (CNS) [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Transcrocetin; trans-Crocetin. CAS No. 27876-94-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N2072. | |
| Crocetin dialdehyde | Crocetin dialdehyde is a natural product that can be found in Saffron[1]. Uses: Scientific research. Group: Natural products. CAS No. 502-70-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N10991. | |
| Crocin | Crocin (Crocin I) is an orally active natural product that can be isolated from the stigma of Crocus sativus. Crocin inhibits tumor cell proliferation and promotes apoptosis through JAK pathway. Crocin has anti-inflammatory, antioxidant and antitumor activities [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Crocin I. CAS No. 42553-65-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0697. | |
| Crocin II | Crocin II is isolated from the fruit of Gardenia jasminoides with antioxidant, anticancer, and antidepressant activity. Crocin II inhibits NO production with an IC 50 value of 31.1 μM. Crocin II suppresses the expressions of protein and m-RNA of iNOS and COX-2 [1]. Uses: Scientific research. Group: Natural products. CAS No. 55750-84-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N0698. | |
| Croconic acid disodium | Croconic acid (disodium) (Nacr) can promote cell growth and proliferation by enhancing the expression of genes associated with lysine crotonylation (Kcr) modification. Croconic acid holds potential for improving somatic cell nuclear transfer (SCNT) efficiency and optimizing cell culture conditions research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Nacr. CAS No. 14379-00-1. Pack Sizes: 50 mg. Product ID: HY-W105310A. | |
| Cromakalim | Cromakalim is a potassium channel opener. Cromakalim can be used as a bronchodilator in asthma. Cromakalim inhibits the spontaneous tone of human isolated bronchi in a concentration-related manner being nearly as effective as isoprenaline or theophylline [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BRL 34915. CAS No. 94470-67-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110011. | |
| Cromolyn | Cromolyn is a mast cell stabilizer. Cromolyn has the potential for the research of bronchial asthma, allergic rhinitis, and certain allergic eye conditions such as vernal conjunctivitis, keratitis, and keratoconjunctivitis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cromoglicic acid. CAS No. 16110-51-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1619. | |
| Cromolyn sodium | Cromolyn sodium (Disodium Cromoglycate; FPL-670) is an antiallergic agent. Cromolyn sodium is a GSK-3β inhibitor with an IC 50 of 2.0 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Disodium Cromoglycate; FPL-670. CAS No. 15826-37-6. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-B0320A. | |
| Cross-linked dextran G 25 | Cross-linked dextran G 25 is a dextran chromatography medium. Cross-linked dextran G 25 separates from 1 to 5 kD (spherical proteins) and can be used for the separation of peptides as well as for the desalting and buffer replacement of large molecule proteins [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9041-35-4. Pack Sizes: 100 mg; 500 mg. Product ID: HY-148140. | |
| Crosstide | Crosstide is a peptide analog of glycogen synthase kinase α/β fusion protein sequence which is a substrate for Akt. Uses: Scientific research. Group: Peptides. CAS No. 171783-05-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P0315. | |
| Crotamiton | Crotamiton is a drug that is used both as a scabicidal (for treating scabies) and as a general antipruritic. Uses: Scientific research. Group: Signaling pathways. CAS No. 483-63-6. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-B1177. | |
| Crotonaldehyde 2,4-dinitrophenylhydrazone-d3 | Crotonaldehyde 2,4-dinitrophenylhydrazone-d 3 is the deuterium labeled Crotonaldehyde 2,4-dinitrophenylhydrazone[1]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 259824-64-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-W013388S. | |
| Crovalimab | Crovalimab (SKY59; RO7112689) is a novel humanized antibody against C5 in a pH-dependent manner with KDs of 15.2?nM and 16.8 μM at pH 7.4 and 5.8, respectively. Crovalimab binds human FcRn with great affinity (KD: 17 μM at pH 6.0). Crovalimab can block cleavage of C5 by the C5 convertase and inhibite the activity of a C5 variant (p.Arg885His). Crovalimab inhibits C5b-9 formation significantly in all three complement pathways, the classical pathway (CP), lectin pathway (LP), and alternative pathway (AP). Crovalimab has the potential for paroxysmal nocturnal hemoglobinuria (PNH) and complement-mediated diseases research [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: SKY59; RO7112689. CAS No. 1917321-26-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99965. | |
| Crozbaciclib | Crozbaciclib (CDK4/6/1 Inhibitor) is a CDK4/6 inhibitor with IC 50 s of 3 and 1 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CDK4/6/1 Inhibitor. CAS No. 2099128-41-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-112280. | |
| Crozbaciclib fumarate | Crozbaciclib fumarate is a CDK4/6 inhibitor with IC 50 s of 3 and 1 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 2567494-39-5. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-112280A. | |
| CRT | CRT, an iron peptide mimic, can bind to apo-transferrin ( apo-Tf ). CRT can be used to modify nanoparticles, and enhances drug delivery efficiency [1]. Uses: Scientific research. Group: Peptides. CAS No. 2414254-70-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5533. | |
| CRT0044876 | CRT0044876 is a potent and selective apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor (IC50=~3 ?M). CRT0044876 inhibits the AP endonuclease, 3?-phosphodiesterase and 3?-phosphatase activities of APE1, and is a specific inhibitor of the exonuclease III family of enzymes to which APE1 belongs. CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 6960-45-8. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W014622. | |
| CRT0066101 | CRT0066101 is a potent and orally active PKD inhibitor with IC 50 values of 1 nM, 2.5 nM and 2 nM for PKD1 , PKD2 , and PKD3 , respectively [1]. CRT0066101 is also a potent PIM2 inhibitor with an IC 50 of ~135.7?nM. CRT0066101 exhibits anti-inflammatory activity in mice LPS (HY-D1056)-induced lung injury models, and has anticancer effects [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 956123-34-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-15698. | |
| CRT0066101 dihydrochloride | CRT0066101 dihydrochloride is a potent and orally active PKD inhibitor with IC 50 values of 1 nM, 2.5 nM and 2 nM for PKD1 , PKD2 , and PKD3 , respectively [1]. CRT0066101 dihydrochloride is also a potent PIM2 inhibitor with an IC 50 of ~135.7?nM. CRT0066101 dihydrochloride exhibits anti-inflammatory activity in mice LPS (HY-D1056)-induced lung injury models, and has anticancer effects [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1883545-60-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15698A. | |
| CRT0066854 | CRT0066854 is a potent and selective atypical PKC isoenzymes inhibitor. CRT0066854 is against full-length (FL) PKCΙ , PKCζ , and ROCK-II kinases with IC 50 values of 132 nM, 639 nM, and 620 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1438881-19-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18713. | |
| CRT0066854 hydrochloride | CRT0066854 hydrochloride is a potent and selective atypical PKC s inhibitor. CRT0066854 is against full-length (FL) PKCΙ , PKCζ , and ROCK-II kinases with IC 50 values of 132 nM, 639 nM, and 620 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2250019-91-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-18713A. | |
| Crustecdysone | Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP[1]. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system[2]. Crustecdysone is an active metabolite of Ecdysone (HY-N0179)[3]. Uses: Scientific research. Group: Natural products. Alternative Names: 20-Hydroxyecdysone. CAS No. 5289-74-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N6979. | |
| Cryptochlorogenic acid | Cryptochlorogenic acid (4-Caffeoylquinic acid) is a naturally occurring phenolic acid compound with oral effectiveness, anti-inflammatory, antioxidant and anti-cardiac hypertrophy effects. Alleviating LPS (HY-D1056) and ISO (HY-B0468) by regulating proinflammatory factor expression, inhibiting NF-?B activity, promoting Nrf2 nuclear transfer, and regulating PI3K?/Akt/ mTOR / HIF-1? signaling pathway Induced physiological stress response[1][2][3]. Uses: Scientific research. Group: Natural products. Alternative Names: 4-Caffeoylquinic acid; 4-O-Caffeoylquinic acid. CAS No. 905-99-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0787. | |
| (-)-Cryptopleurine | ( - )-Cryptopleurine is an alkaloid that has been found in Lauraceae and has diverse biological activities. It inhibits the growth of human A375 melanoma, A431 epidermoid carcinoma, A549 lung, MES-SA uterine sarcoma, and MCF-7 breast cancer cells ( IC 50 =3 nM for all).2 ( - )-Cryptopleurine inhibits hypoxia-induced gene expression in a hypoxia response element (HRE) reporter assay ( IC 50 =8.7 nM).3 ( - )-Cryptopleurine (500 μg/mL) prevents lesion formation in tobacco (N. tabacum) plants infected with tobacco mosaic virus (TMV). It also inhibits protein synthesis by yeast and mammalian ribosomes. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (R)-Cryptopleurine; NSC 19912. CAS No. 482-22-4. Pack Sizes: 1 mg. Product ID: HY-121255. | |
| Cryptotanshinone | Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC 50 of 4.6 μM. Uses: Scientific research. Group: Natural products. Alternative Names: Cryptotanshinon; Tanshinone c. CAS No. 35825-57-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-N0174. | |
| Crystal Ponceau 6R | Crystal Ponceau 6R is a red azo dye. Crystal Ponceau 6R used in histology, for staining fibrin with the martius, scarlet and blue (MSB) Trichrome stain [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 2766-77-0. Pack Sizes: 500 mg; 1 g; 5 g. Product ID: HY-D1480. | |
| Crystal Violet | Crystal Violet, also known as Gentian violet, methyl violet 10B, is a triphenyl-methane, an alkaline dye that binds to DNA in the nucleus of a cell, staining it a deep purple. It is often used for Gram staining to classify bacteria, or for cell or histological staining[1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Basic Violet 3; Gentian Violet; Methyl Violet 10B. CAS No. 548-62-9. Pack Sizes: 500 mg; 5 g; 10 g. Product ID: HY-B0324A. | |
| CS-2100 | CS-2100 (Compound 10b) is a potent, selective, orally active and S1P 3 -sparing S1P 1 agonist with an EC 50 of 4.0 nM for human S1P 1. CS-2100 shows in vivo immunosuppressive efficacy in rats with an ID 50 (infective dose) of 0.407 mg/kg for HvGR [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 913827-99-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108493. | |
| CS-6253 | CS-6253 is an agonist of ABCA1. CS-6253 can regulate lipoprotein metabolism, promote high-density lipoprotein biogenesis, and cellular cholesterol efflux. CS-6253 also has certain neuroprotective effects and can clear A? from the brain. CS-6253 can be used for research on cholesterol metabolism and diseases such as Alzheimers disease[1][2][3]. Uses: Scientific research. Group: Peptides. CAS No. 1627911-44-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P6306. | |
| CS640 | CS640 is a selective inhibitor of calmodulin-dependent kinases. CS640 inhibits CaMK1D, CaMK1B, CaMK1A, CaMK1G, PIP5K1C, MEK5, RIPK4 and MLK3 with IC50 values of 0.08, 0.03, 0.001, 0.001, 11.2, 0.025, 5.69 and 2.75 ?M, respectively. CS640 also shows inhibitory effects to CYP450 2C9 and CYP450 2C19 with IC50 values of 6 and 10 ?M, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2388506-83-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148907. | |
| CSF1R-IN-24 | CSF1R-IN-24 (Example 134) is an orally active CSF1R inhibitor. CSF1R-IN-24 significantly inhibits the survival of human ipSC-derived microglia (hiPSC-MG) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3024322-57-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-160842. | |
| CSF1R-IN-3 | CSF1R-IN-3 (compound 21) is a potent and orally active CSF-1R inhibitor ( IC 50 =2.1 nM). CSF1R-IN-3 is a potent antiproliferative activity against colorectal cancer cells. CSF1R-IN-3 inhibits the progression of colorectal cancer by suppressing the migration of macrophages, reprograming M2-like macrophages to the M1 phenotype, and enhancing the antitumor immunity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2760584-90-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139990. | |
| CSK-IN-1 | CSK-IN-1 (compound 13) is a potent, orally active c-terminal Src kinase (CSK) with IC50 values below 3 nM and 4 nM in CSK HTRF and Caliper assay, respectively. CSK-IN-1 shows the ability to increase T cell proliferation induced by T cell receptor signaling[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2380027-49-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130254. | |
| CSN5i-3 | CSN5i-3 is a potent, selective and orally available inhibitor of CSN5/Jab1, and inhibits CSN-catalysed Cul1 deneddylation with an IC50 value of 5.8 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2375740-98-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112134. | |
| CSP1 | CSP1 is a potent and selective ComD1 receptor agonist, with an IC 50 of 10.3 nM. CSP1 is a major variants of competence-stimulating peptide (CSP), and it can regulate genetic transformation of S. pneumonia by modulating quorum sensing (QS). CSP1 can act as an antibacterial agent [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 172889-49-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2454. | |
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