MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| CSRM617 hydrochloride | CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 hydrochloride induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 hydrochloride is well tolerated in the prostate cancer mouse model[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1353749-74-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122611A. |  |
| CST626 | CST626 (Compound 9) is a pan- IAP degrader PROTAC. CST626 degrades XIAP, cIAP1 and cIAP2 with DC 50 s of 0.7, 2.4, and 6.2 nM in MM.1S cells, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3033993-13-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-149924. | |
| CT1812 | CT1812 (Sigma-2 receptor antagonist 1) is an orally active and brain penetrant sigma-2 receptor antagonist with a K i of 8.5 nM. CT1812 can be used for the research of Alzheimers disease [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Sigma-2 receptor antagonist 1. CAS No. 1802632-22-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-111669. | |
| CTB | CTB is a potent p300 histone acetyltransferase activator [1]. CTB can effectively induce apoptosis in MCF-7 cells [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 451491-47-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134964. | |
| CTCE-9908 | CTCE-9908 is a potent and selective CXCR4 antagonist. CTCE-9908 induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovarian cancer cells [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 1030384-98-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P1103. | |
| CTEP | CTEP (RO 4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC 50 of 2.2 nM, and shows > 1000-fold selectivity over other mGlu receptors. CTEP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RO 4956371; mGluR5 inhibitor. CAS No. 871362-31-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15445. | |
| CTP | CTP is a cardiac targeting peptide. CTP transduces cardiomyocytes in vitro. CTP leads to efficient and specific transduction of heart tissue in mice model. CTP can be used to deliver therapeutic peptides, proteins and nucleic acid specifically to the heart [1]. Uses: Scientific research. Group: Peptides. CAS No. 1052692-86-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P4094. | |
| CTPB | CTPB is a good activator of p300 histone acetyl transferase ( HAT ) enzyme [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 586976-24-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124960. | |
| CTPI-2 | CTPI-2 is a third-generation mitochondrial citrate carrier SLC25A1 inhibitor with a KD of 3.5 ?M. CTPI-2 inhibits glycolysis, PPAR?, and its downstream target the glucose transporter GLUT4. CTPI-2 halts salient alterations of NASH reverting steatosis, preventing the evolution to steatohepatitis, reducing inflammatory macrophage infiltration in the liver and adipose tissue, and starkly mitigating obesity induced by a high-fat diet. Antitumor activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 68003-38-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg. Product ID: HY-123986. | |
| CTS-1027 | CTS-1027 is a potent small molecule inhibitor of MMPs, with IC50s of 0.3 nM, 0.5 nM for MMP2, MMP13, respectively, and has > 1,000 fold selectivity over MMP1. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ro 1130830; RS 130830. CAS No. 193022-04-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10398. | |
| CTX-0294885 | CTX-0294885 is a broad spectrum kinase inhibitor that can capture 235 kinases from MDA-MB-231 cells, and can capture all members of the AKT family. CTX-0294885 is a powerful reagent for analysis of kinome signaling networks that can be used for the research of diseases like inflammation, diabetes, and cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1439934-41-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15985. | |
| CTX1 | CTX1 is a p53 activator that overcomes HdmX-mediated p53 repression. CTX1 exhibits potent anti-cancer activity in a mouse acute myeloid leukemia (AML) model system [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 501935-96-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-U00442. | |
| CTX-471 | CTX-471 is a fully human monoclonal antibody of CD137. CTX-471 has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with K d values of 50 nM, 61 nM and 748 nM, respectively. CTX-471 can be used for the research of immunomodulation and cancer [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2377152-49-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99178. | |
| CTX-712 | CTX-712 is an orally effective CLK 2 inhibitor, with an IC 50 of 1.4 nM, showing anti-tumor activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2144751-78-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144875. | |
| C-Type Natriuretic Peptide (CNP) (1-22), human | C-Type Natriuretic Peptide (CNP) (1-22), human, a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor[1][2][3]. Uses: Scientific research. Group: Peptides. CAS No. 127869-51-6. Pack Sizes: 500 ?g; 1 mg; 5 mg; 10 mg. Product ID: HY-P1237. | |
| CU-32 | CU-32 is a potent cGAS inhibitor with an IC 50 of 0.45 μM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2400954-16-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-132221. | |
| CuATSM | CuATSM is a copper complex that scavenges free radicals, inhibits lipid peroxidation and ferroptosis. CuATSM exhibits antioxidant, anti-inflammatory and neuroprotective activities [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 68341-09-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139827. | |
| CU-CPT22 | CU-CPT22 is a potent protein complex of toll-like receptor 1 and 2 (TLR1/2) inhibitor, and competes with the synthetic triacylated lipoprotein (Pam3CSK4) binding to TLR1/2 with a Ki of 0.41 μM. CU-CPT22 blocks Pam3CSK4-induced TLR1/2 activation with an IC50 of 0.58 μM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1416324-85-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108471. | |
| CU-CPT 4a | CU-CPT 4a (TLR3-IN-1) is a potent, highly selective TLR3 signaling inhibitor. CU-CPT 4a represses the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TLR3-IN-1. CAS No. 1279713-77-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108473. | |
| Cucurbit[7]uril | Cucurbit[7]uril is a cyclic organic molecule consisting of seven glycoluril units linked by methylene bridges. It has a rigid barrel-like structure with two identical inlets at both ends to selectively encapsulate guest molecules of appropriate size, shape, and polarity. Cucurbit[7]uril is known for its high binding affinity for a variety of organic and inorganic guests, including drugs, amino acids, peptides, and metal ions. This property makes them promising candidates for various applications in areas such as drug delivery, catalysis, and sensing. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: CB7; Carrier CB7. CAS No. 259886-50-5. Pack Sizes: 25 mg; 50 mg. Product ID: HY-104086. | |
| Cucurbit[8]uril | Cucurbit[8]uril is a potent, low toxicity and orally active supramolecular inducer of protein heterodimerization. Cucurbit[8]uril induces heterodimerization of methylviologen and naphthalene functionalized proteins. Cucurbit[8]uril can induce energy transfer [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 259886-51-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103689. | |
| Cucurbitacin B | Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 6199-67-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0416. | |
| Cucurbitacin D | Cucurbitacin D is the active ingredient in Trichosanthes kirilowii and can disrupt the interaction between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D is an inflammasome activator. Cucurbitacin D induces cell cycle arrest and cell apoptosis , exhibiting anti-tumor and anti-inflammatory effects [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 3877-86-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N1986. | |
| Cucurbitacin I | Cucurbitacin I is a natural selective inhibitor of JAK2/STAT3, with potent anti-cancer activity. Uses: Scientific research. Group: Natural products. Alternative Names: Elatericin B; JSI-124; NSC-521777. CAS No. 2222-7-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N1405. | |
| Cucurbitacin IIa | Cucurbitacin IIa is a triterpene isolated from Hemsleya amalils Diels, induces apoptosis of cancer cells, reduces expression of survivin , reduces phospho-Histone H3 and increases cleaved PARP in cancer cells [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Hemslecin A. CAS No. 58546-34-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N1988. | |
| Cucurbituril | Cucurbituril is a container molecule resembling a hollow pumpkin, with two identical inlets at each end and a hydrophobic cavity in the middle. Cucurbiturils have unique chemical properties that allow them to selectively encapsulate guest molecules such as drugs or catalysts within their cavities, shielding them from the surrounding environment. Cucurbituril has important potential applications in various fields such as drug delivery, catalysis and materials science. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 80262-44-8. Pack Sizes: 100 mg; 250 mg; 1 g. Product ID: HY-W130354. | |
| CUDA | CUDA is a potent inhibitor of soluble epoxide hydrolase (sEH) , with IC 50 s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively [1]. CUDA selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity. CUDA may be valuable for the research of cardiovascular disease [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 479413-68-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121538. | |
| CUDC-101 | CUDC-101 is a potent inhibitor of HDAC , EGFR , and HER2 with IC 50 s of 4.4, 2.4, and 15.7 nM, respectively. CUDC-101 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1012054-59-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10223. | |
| Cudetaxestat | Cudetaxestat (BLD-0409) is a potent and orally active autotaxin (ATX) inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BLD-0409. CAS No. 1782070-21-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145561. | |
| Cue-lure | Cue-lure (Q-lure) is a melon fly attractant [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Q-lure. CAS No. 3572-6-3. Pack Sizes: 10 mM * 1 mL; 25 mg. Product ID: HY-N7099. | |
| CUG | CUG (3-Carboxyumbelliferyl-β-D-galactopyranoside) is a fluorogenic substrate (λ ex =386, λ em =445 nm, ε=32K). Uses: Scientific research. Group: Fluorescent dye. Alternative Names: 3-Carboxyumbelliferyl-β-D-galactopyranoside. CAS No. 64664-99-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-D1026. | |
| Cu(II)-Elesclomol | Cu(II)-Elesclomol is a complex formed by Elesclomol (HY-12040) and Cu2+ (copper ions). Cu(II)-Elesclomol is also a weak inhibitor of DNA topoisomerase I. Cu(II)-Elesclomol exerts anticancer effects by inducing oxidative stress and DNA damage through copper chelation. Cu(II)-Elesclomol can inhibit tumor cell proliferation and induce cell cycle arrest and apoptosis. Cu(II)-Elesclomol can be used in the study of cancer[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1224195-72-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156376. | |
| Cu(II)GTSM | Cu(II)GTSM, a cell-permeable Cu-complex, significantly inhibits GSK3?. Cu(II)GTSM inhibits Amyloid-? oligomers (A?Os) and decreases tau phosphorylation. Cu(II)GTSM also decreases the abundance of Amyloid-? trimers. Cu(II)GTSM is a potential anticancer and antimicrobial agent[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 68341-14-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139324. | |
| Cu(II) protoporphyrin IX | Cu (II) Protoporphyrin IX is used as a negative control for Zn (II) Protoporphyrin (an inihibitor of heme oxygenase). Heme oxygenase has been implicated in tumor cell resistance to chemotherapy, reduction of free radical formation and inflammation, and associated with vascular repair [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 14494-37-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-136476B. | |
| Cuminaldehyde | Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase ( IC 50 = 0.00085 mg/mL), α-glucosidase ( IC 50 =0.5 mg/mL) and lipoxygenase ( IC 50 =1370 μM). Cuminaldehyde also inhibits the fibrillation of α-synuclein and prevents its aggregation. Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Natural products. Alternative Names: p-Isopropylbenzaldehyde. CAS No. 122-03-2. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-Y0790. | |
| Cuprizone | Cuprizone is a copper chelating agent that forms a deep blue copper ketone complex with copper (II). The copper ketone reaction can be used in colorimetric tests for the presence of trace copper. Cuprizone can be used to induce some schizophrenia-like behavior in mice. Cuprizone acts on copper enzymes, including SOD1, cytochrome oxidase, and DβH, thereby causing oxidative stress and increasing DA levels in certain brain regions such as the medial prefrontal cortex (PFC) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 370-81-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-W115718. | |
| Cuprous iodide | Cuprous iodide (Copper(I) iodide) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Copper(I) iodide. CAS No. 7681-65-4. Pack Sizes: 25 g. Product ID: HY-Y0961. | |
| Curcumenol | Curcumenol ((+)-Curcumenol) is a potent CYP3A4 inhibitor with an IC 50 of 12.6 μM, which is one of constituents in the plants of medicinally important genus of Curcuma zedoaria , with neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. Curcumenol ((+)-Curcumenol) suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (+)-Curcumenol. CAS No. 19431-84-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-N2259. | |
| Curcumin | Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs , and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification. Uses: Scientific research. Group: Natural products. Alternative Names: Diferuloylmethane; Natural Yellow 3; Turmeric yellow. CAS No. 458-37-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-N0005. | |
| Curcumin-β-D-glucuronide | Curcumin-β-D-glucuronide is a major metabolite after oral intake of Curcumin in hepatic tissue and portal blood. Curcumin-β-D-glucuronide can be used for the research of colon cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 227466-72-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138795. | |
| Curcumin (Standard) | Curcumin (Standard) is the analytical standard of Curcumin. This product is intended for research and analytical applications. Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification. Uses: Scientific research. Group: Natural products. CAS No. 458-37-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0005R. | |
| Curdlan | Curdlan is a polysaccharide found in bacteria, consisting of a glucose homopolymer with β-1,3-glycosidic linkages [1]. Curdlan can be recognized by Dectin-1 (a C-type lectin receptor), inducing immune responses in tissue mast cells and enhancing dendritic cell effects in tumor immunity. Curdlan holds potential for research in cancer and immune-inflammatory diseases [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 54724-00-4. Pack Sizes: 500 mg. Product ID: HY-131166. | |
| Curvulin | Curvulin is a phytotoxin [1]. Curvularin inhibits microtubule assembly and inhibits iNOS expression. Uses: Scientific research. Group: Signaling pathways. CAS No. 19054-27-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-119692. | |
| Curzerene | Curzerene is a sesquiterpene is isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity. Curzerene inhibits glutathione S-transferase A1 ( GSTA1 ) mRNA and protein expression. Curzerene induces cell apoptosis [1]. Uses: Scientific research. Group: Natural products. CAS No. 17910-09-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N1963. | |
| Curzerenone | Curzerenone is one of constituents of leaf essential oil extracted from L. pulcherrima. Shows slight inhibitory effective against E. coli [1]. Uses: Scientific research. Group: Natural products. CAS No. 20493-56-5. Pack Sizes: 5 mg. Product ID: HY-N3651. | |
| Cusatuzumab | Cusatuzumab (ARGX-110) is a human αCD70 monoclonal antibody. Cusatuzumab has the activity of enhancied antibody-dependent cellular cytotoxicity (ADCC). Cusatuzumab blocks the CD70/CD27 signaling pathway, reduces leukemia stem cells (LSCs) and triggers gene signatures related to myeloid differentiation and apoptosis. Cusatuzumab can be used to study leukemia [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: ARGX-110. CAS No. 1864871-20-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99014. | |
| CVN293 | CVN293 is a selective and brain permeable potassium ion (K+) channel KCNK13 inhibtor with IC50s of 41 nM and 28 nM for hKCNK13 and mKCNK13, respectively. CVN293 potently inhibits the NLRP3-inflammasome mediated production of the proinflammatory cytokine IL-1? in microglia[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2815296-08-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158155. | |
| CVN424 | CVN424 is an orally active and selective GPR6 inverse agonist with a K i of 9.4 nM and an EC 50 of 38 nM. CVN424 is brain-penetrant and has the potential for Parkinson disease research [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2254706-21-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134661A. | |
| CVT-10216 | CVT-10216 is a highly selective, reversible aldehyde dehydrogenase-2 (ALDH-2) inhibitor with an IC50 of 29 nM. CVT-10216 also has inhibitory effect of ALDH-1 with an IC50 of 1.3 ?M. CVT-10216 can reduce excessive alcohol drinking in alcohol-preferring rats and exhibit anxiolytic effects[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1005334-57-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19801. | |
| CVT-313 | CVT-313 (Cdk2 Inhibitor III) is a potent, selective, reversible, and ATP-competitive inhibitor of CDK2 with IC 50 of 0.5 μM. CVT-313 inhibits CDC5L phosphorylation [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cdk2 Inhibitor III. CAS No. 199986-75-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15339. | |
| CW-069 | CW-069 is an allosteric inhibitor of microtubule motor protein HSET with an IC50 of 75 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 1594094-64-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15857. | |
| CWHM-1008 | CWHM-1008 is a potent and orally active antimalarial agent, with EC 50 values of 46 and 21 nM against agent-sensitive Plasmodium falciparum 3D7 and drug-resistant Dd2 strains, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2362539-97-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-111746. | |
| CWHM-12 | CWHM-12 is a potent inhibitor of ?V integrins with IC50s of 0.2, 0.8, 1.5, and 1.8 nM for ?v?8, ?v?3, ?v?6, and ?v?1. Uses: Scientific research. Group: Signaling pathways. CAS No. 1564286-55-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18644. | |
| CWI1-2 | CWI1-2 is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2408590-36-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153274. | |
| CX516 | CX516 (BDP 12) is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BDP 12. CAS No. 154235-83-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10933. | |
| CX546 | CX546 is a first-generation and selective benzamide-type positive AMPAR modulator. CX546 is a prototypical ampakine agent and has antipsychotic effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 215923-54-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12505. | |
| CX-5461 | CX-5461 is a potent and oral rRNA synthesis inhibitor. It inhibits RNA polymerase I-driven transcription of rRNA with IC50s of 142, 113, and 54 nM in HCT-116, A375, and MIA PaCa-2 cells, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1138549-36-6. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13323. | |
| CX-5461 dihydrochloride | CX-5461 dihydrochloride is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC50s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC50 ?25 ?M). Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13323A. | |
| CX-6258 | CX-6258 is a potent and kinase selective pan-Pim kinases inhibitor, with IC50s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1202916-90-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18095. | |
| CX-6258 hydrochloride hydrate | CX-6258 hydrochloride hydrate is a potent and kinase selective pan-Pim kinases inhibitor, with IC 50 s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1353858-99-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18095A. | |
| CX 717 | CX 717 is a positive allosteric modulator of AMPA receptor. Antidepressant-like effect. CX 717 can be used for the research of adult attention deficit hyperactivity disorder (ADHD) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 867276-98-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139897. | |
| CXCR2 antagonist 2 | CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunoresearch with an IC 50 value of 95 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 2647464-91-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139873. | |
| CXCR7 antagonist-1 | CXCR7 antagonist-1 is a CXCR7 antagonist that inhibits the binding of the SDF-1 chemokine (also known as the CXCL12 chemokine) or I-TAC (also known as CXCL11) to the chemokine receptor CXCR7. CXCR7 antagonist-1 is useful in preventing tumor cell proliferation, tumor formation, inflammatory diseases, and many other diseases[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1613021-99-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139643. | |
| CY-09 | CY-09 is a selective and direct NLRP3 inhibitor. CY-09 directly binds to the ATP-binding motif of NLRP3 NACHT domain and inhibits NLRP3 ATPase activity, resulting in the suppression of NLRP3 inflammasome assembly and activation[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1073612-91-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103666. | |
| Cy2-SE (iodine) | Cy2-SE iodine is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis[1]. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance[2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Cyanine2 Succinimidyl Ester (iodine). CAS No. 186205-33-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-D0826. | |
| CY3 | Cy3 (Sulfo-Cyanine3) is an orange-fluorescent label for protein and nucleic acid (?ex=554, ?em=568). Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Sulfo-Cyanine3. CAS No. 146368-13-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D0822. | |
| Cy3B NHS ester | Cy3B NHS ester is a fluorescent dye compound that is commonly used in biomarking and fluorescent labeling experiments, especially for labeling biomolecules containing amino functional groups (amine groups), such as proteins, antibodies or peptides. Uses: Scientific research. Group: Fluorescent dye. CAS No. 228272-52-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D1849. | |
| Cy3 maleimide chloride | Cy3 maleimide chloride is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing maleimide functional groups. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The alkyne functional group of Cy3 maleimide chloride can undergo a "thiol-acrylamide" reaction with molecules containing sulfur-oxygen functional groups to form covalent bonds. Cy3 maleimide chloride can bind to biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples. Uses: Scientific research. Group: Fluorescent dye. CAS No. 1838643-41-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D1871. | |
| Cy3 NHS ester | Cy3 NHS ester is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis[1]. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance[2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Cyanine3 NHS ester. CAS No. 1393363-07-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112498. | |
| CY3-SE | Cy3-SE (Sulfo-Cy3 NHS ester; Sulfo Cyanine3 NHS ester) is a sulfonated cyanine dye-derived fluorescent labeling reagent with ?ex of about 515 nm and ?em of about 568 nm. Cy3-SE can interact with the ?-? stacking of biomolecules (e.g., nucleoside monophosphates, proteins), inhibiting the photoisomerization process and increasing the fluorescence quantum yield and lifetime[1][2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Sulfo-Cy3 NHS ester; Sulfo Cyanine3 NHS ester. CAS No. 146368-16-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-D0823. | |
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