MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Dalotuzumab | Dalotuzumab (MK-0646) is a recombinant humanized monoclonal antibody (IgG1 type) targeting IGF-1R. Dalotuzumab acts by inhibiting IGF-1 - and IGF-2 -mediated tumor cell proliferation, IGF-1R autophosphorylation, and Akt phosphorylation. Dalotuzumab also induces apoptosis and cycle arrest. Dalotuzumab in combination with other anticancer agents such as statins can enhance the antitumor activity of Dalotuzumab in vitro and in vivo [1] [2] [3]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MK-0646; h7C10. CAS No. 1005389-60-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99284. |  |
| D-α-Tocopherol acetate | D-α-Tocopherol acetate (D-Vitamin E acetate) can be hydrolyzed to d-alpha-tocopherol (VE) and absorbed in the small intestine [1]. Uses: Scientific research. Group: Natural products. Alternative Names: D-Vitamin E acetate. CAS No. 58-95-7. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g; 10 g; 25 g; 50 g. Product ID: HY-B1278. | |
| D-α-Tocopherol Succinate | D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Vitamin E succinate. CAS No. 4345-3-3. Pack Sizes: 100 mg; 250 mg; 500 mg. Product ID: HY-131553. | |
| D-α-Tocopherylquinone | D-α-Tocopherylquinone (α-Tocopherylquinone) is a quinone, can be isolated from Phaeodactylum tricornutum. D-α-Tocopherylquinone is a oxidation product of α-Tocopherol (vitamin E). D-α-Tocopherylquinone can act as an anticoagulant and as an antioxidant [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: α-Tocopherylquinone. CAS No. 7559-4-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-N2853. | |
| Dalpiciclib | Dalpiciclib (SHR-6390) is an orally active and highly selective inhibitor of CDK4 and 6 with IC 50 values of 12.4 nM and 9.9 nM, respectively [1] [2]. Dalpiciclib shows antitumor activity against breast cancer and esophageal squamous cell carcinoma [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SHR-6390. CAS No. 1637781-04-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-114338. | |
| Dalpiciclib hydrochloride | Dalpiciclib (SHR-6390) hydrochloride is an orally active and highly selective inhibitor of CDK4 and 6 with IC 50 values of 12.4?nM and 9.9?nM, respectively [1] [2]. Dalpiciclib hydrochloride shows antitumor activity against breast cancer and esophageal squamous cell carcinoma [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SHR-6390 hydrochloride. CAS No. 2891598-76-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114338A. | |
| Dalutrafusp alfa | Dalutrafusp alfa (AGEN-1423; GS-1423) is a specific bifunctional antibody against CD73 and TGF-β , which is involved in the immunosuppressive pathway [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: AGEN-1423; GS-1423. CAS No. 2419918-89-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99841. | |
| Damascenone | Damascenone ((E/Z)-Damascenone) is an active compound of Epipremnum pinnatum with anti-inflammatory activity [1]. Damascenone is a mixture complex of E-isomer-Damascenone and Z-isomer Damascenone. Uses: Scientific research. Group: Natural products. Alternative Names: (E/Z)-Damascenone. CAS No. 23696-85-7. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-N2543. | |
| DAMGO | DAMGO is a μ-opioid receptor ( μ-OPR ) selective agonist with a K d of 3.46 nM for native μ-OPR [1]. Uses: Scientific research. Group: Peptides. CAS No. 78123-71-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0210. | |
| DAMGO TFA | DAMGO TFA is a μ-opioid receptor ( μ-OPR ) selective agonist with a K d of 3.46 nM for native μ-OPR [1]. Uses: Scientific research. Group: Peptides. CAS No. 950492-85-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-P0210B. | |
| D-Amino acid oxidase (Immobilized) | D-Amino acid oxidase is an enzyme to metabolize exogenous D-amino acids in animals for detoxifying action. D-Amino acid oxidase also modulates the level of D-serine in brain [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9000-88-8. Pack Sizes: 25 U. Product ID: HY-P2986. | |
| Daminozide | Daminozide, a plant growth regulator, is a selective inhibitor of the human KDM2/7 histone demethylases , with IC 50 s of 0.55, 1.5 and 2.1 μM for PHF8 , KDM2A , and KIAA1718 , respectively. Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 1596-84-5. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-13643. | |
| Damnacanthal | Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56 lck tyrosine kinase activity. Natural Damnacanthal inhibits p56 lck autophosphorylation and phosphorylation of exogenous substrates with IC 50 s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti-inflammatory effects in mice and anti-fungal activity against Candida albicans [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 477-84-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-108485. | |
| Danavorexton | Danavorexton (TAK-925) is an orexin receptor agonist with brain permeability. Danavorexton induces a physiological pattern of OX2R activation in vitro to wake up sleepy mice and improve sleepiness symptoms [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TAK-925. CAS No. 2114324-48-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133898. | |
| Danazol | Danazol inhibits the proliferation of cancer cell MDA-MB-231 and MCF-7 with IC 50 of 65 μg/mL and 31 μg/mL. Danazol arrests the cell cycle at G1 phase, induces apoptosis in MDA-MB-231 through PKCα signaling pathway [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 17230-88-5. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg. Product ID: HY-B1029. | |
| Danegaptide Hydrochloride | Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effect[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GAP-134 Hydrochloride; ZP 1609 Hydrochloride. CAS No. 943133-81-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10913A. | |
| Danicamtiv | Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MYK-491. CAS No. 1970972-74-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109128. | |
| Danicopan | Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with K d value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ACH-4471. CAS No. 1903768-17-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117930. | |
| Danofloxacin | Danofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent. Danofloxacin shows a broad spectrum of activity against most Gram-negative and Gram-positive bacteria , mycoplasma and chlamydia species , and plays an antimicrobial role by inhibition of bacterial DNA-gyrase. Danofloxacinh has the potential for respiratory diseases in cattle, swine, and chickens treatment [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 112398-08-0. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-W011117. | |
| Danofloxacin mesylate | Danofloxacin mesylate (CP 76136-27) is a fluoroquinolone used as a veterinary drug. Danofloxacin mesylate has a broad spectrum of bactericidal activity, mainly inhibiting the DNA cycloenzyme of the bacteria. In addition, Danofloxacin mesylate is a substrate for ATP-dependent efflux transporters ( P-gp and MRP2 ) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CP 76136-27. CAS No. 119478-55-6. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B0501. | |
| Danoprevir | Danoprevir (ITMN-191) is an orally active NS3/4A protease inhibitor for hepatitis C virus (HCV) with an IC 50 of 0.29 nM and is selective for NS3/4A over a panel of 53 proteases ( IC 50 higher than 10 μM). Danoprevir (ITMN-191) inhibits HCV genotypes 1a, 1b, 4, 5, and 6 ( IC 50 s=0.2-0.4 nM) as well as 2b and 3a ( IC 50 s=1.6, 3.5 nM) [1] [2]. Danoprevir is also a SARS-CoV 3CL pro inhibitor with an IC 50 of 0.05 μM [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ITMN-191; R7227; RO5190591; RG7227. CAS No. 850876-88-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10238. | |
| Danshensu | Danshensu (Dan shen suan A), an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu reduces reactive oxygen species ( ROS ) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu displays a potent antiviral activity against SARS-CoV-2 with EC 50 of 0.97?μM. Danshensu has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Dan shen suan A; Salvianic acid A. CAS No. 76822-21-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N1913. | |
| Danshensu sodium | Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu sodium reduces reactive oxygen species ( ROS ) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu sodium displays a potent antiviral activity against SARS-CoV-2 with EC 50 of 0.97?μM. Danshensu sodium has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Dan shen suan A sodium; Salvianic acid A sodium. CAS No. 81075-52-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N1913A. | |
| Dansylcadaverine | Dansylcadaverine (Monodansyl cadaverine) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine, a high affinity substrate of transglutaminases, can block the receptor-mediated endocytosis of many ligands[1][2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Monodansyl cadaverine. CAS No. 10121-91-2. Pack Sizes: 50 mg; 100 mg. Product ID: HY-D1027. | |
| Dansyl chloride | Dansyl chloride is a reagent that produces stable blue or blue-green fluorescent sulfonamide adducts in the reaction of aliphatic and aromatic amines with primary amino groups, and is widely used for modified amino acids, protein sequencing and amino acid analysis [1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: DNSCl. CAS No. 605-65-2. Pack Sizes: 1 g; 5 g; 10 g. Product ID: HY-D0017. | |
| Dansyl hydrazine | 5-(Dimethylamino)naphthalene-1-sulfonohydrazide is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 33008-06-9. Pack Sizes: 1 g; 5 g. Product ID: HY-W009411. | |
| Danthron | Danthron is a natural product extracted from the traditional Chinese medicine Salvia miltiorrhiza Bunge. Danthron functions in regulating glucose and lipid metabolism by activating AMPK. Uses: Scientific research. Group: Natural products. Alternative Names: Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone. CAS No. 117-10-2. Pack Sizes: 10 mM * 1 mL; 100 mg; 1 g; 5 g. Product ID: HY-B0923. | |
| Dantrolene | Dantrolene is an orally active, non-competitive glutathione reductase inhibitor with a K i of 111.6 μM and an IC 50 of 52.3 μM. Dantrolene is also a calcium channel protein inhibitor. Dantrolene inhibits the release of Ca 2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: F 368. CAS No. 7261-97-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12542. | |
| Dantrolene sodium | Dantrolene sodium is an orally active, non-competitive glutathione reductase inhibitor with a K i of 111.6 μM and an IC 50 of 52.3 μM. Dantrolene sodium is also a calcium channel protein inhibitor. Dantrolene sodium inhibits the release of Ca 2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene sodium offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: F 440. CAS No. 14663-23-1. Pack Sizes: 100 mg; 500 mg. Product ID: HY-14657. | |
| Dantrolene sodium hemiheptahydrate | Dantrolene sodium hemiheptahydrate is an orally active, non-competitive glutathione reductase inhibitor with a K i of 111.6 μM and an IC 50 of 52.3 μM. Dantrolene sodium hemiheptahydrate is also a calcium channel protein inhibitor. Dantrolene sodium hemiheptahydrate inhibits the release of Ca 2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene sodium hemiheptahydrate offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Dantrolene sodium hydrate. CAS No. 24868-20-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-12542A. | |
| Danuglipron | Danuglipron (PF-06882961) is an orally active glucagon-like peptide-1 receptor (GLP-1R) agonist. Danuglipron has the potential for type 2 diabetes research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-06882961. CAS No. 2230198-02-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125824. | |
| Danusertib | Danusertib is a pyrrolo-pyrazole and aurora kinase inhibitor with IC50 of 13, 79, and 61 nM for Aurora A, B, and C, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PHA-739358. CAS No. 827318-97-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10179. | |
| DAOS | DAOS, a Trinder's reagent, is a novel highly water-soluble aniline derivative; are widely used in diagnostic tests and biochemical tests. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 83777-30-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg. Product ID: HY-15913. | |
| D-AP5 | D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a K d of 1.4 μM. D-AP5 (D-APV) inhibits the glutamate binding site of NMDA receptors [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: D-APV; D-2-Amino-5-phosphonovaleric acid. CAS No. 79055-68-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100714A. | |
| Dapagliflozin | Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 ( SGLT2 ) inhibitor, which results in excretion of glucose into the urine [1]. Dapagliflozin induces HIF1 expression and attenuates renal IR injury [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-512148. CAS No. 461432-26-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10450. | |
| Dapagliflozin ((2S)-1,2-propanediol, hydrate) | Dapagliflozin ((2S)-1,2-propanediol, hydrate) is the S-enantiomer of Dapagliflozin 1,2-propanediol, hydrate. Dapagliflozin ((2S)-1,2-propanediol, hydrate), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine[1]. Dapagliflozin ((2S)-1,2-propanediol, hydrate) induces HIF1 expression and attenuates renal IR injury[2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-512148 (2S)-1,2-propanediol, hydrate. CAS No. 960404-48-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10450A. | |
| Dapagliflozin-3-O-β-D-glucuronide | Dapagliflozin-3-O-β-D-glucuronide (BMS-801576) is the metabolite of Dapagliflozin (HY-10450), and is formed in the liver and kidney by uridine diphosphate glucuronosyltransferase-1A9 (UGT1A9). Dapagliflozin is a selective inhibitor for SGLT2 , that can be used to improve glycemic control and attenuate type 2 diabetes [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-801576. CAS No. 1351438-75-9. Pack Sizes: 500 μg; 1 mg. Product ID: HY-125156. | |
| Dapagliflozin impurity | Dapagliflozin impurity is an enantiomer of Dapagliflozin which is a sodium-glucose transporter 2 inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 960404-86-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-128723. | |
| Dapansutrile | Dapansutrile is a potent, orally active and selective NLRP3 inflammasome inhibitor. Dapansutrile has anti-inflammatory activity and decreases immune factor levels. Dapansutrile can be used for research of inflammatory diseases [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: OLT1177. CAS No. 54863-37-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17629. | |
| Daphnetin | Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne , is a potent, oral active protein kinase inhibitor, with IC 50 s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1 , ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: 7,8-Dihydroxycoumarin. CAS No. 486-35-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0281. | |
| DAPI dihydrochloride | DAPI dihydrochloride is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. In addition, because DAPI can pass through intact cell membranes, it can be used to stain both live and fixed cells [1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: 4',6-Diamidino-2-phenylindole dihydrochloride. CAS No. 28718-90-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-D0814. | |
| DAPI (dihydrochloride) (solution) | DAPI dihydrochloride (4',6-Diamidino-2-phenylindole dihydrochloride) (solution) is a DAPI dye. DAPI is a fluorescent dye that can bind strongly to DNA. DAPI binds to the A/T base pairs in the minor groove of double-stranded DNA (1 DAPI molecule can occupy 3 base pairs), which amplifies the fluorescence intensity by about 20 times. By observing the fluorescence intensity, DNA can be quantified. DAPI can also penetrate intact cell membranes and is often used to stain living and fixed cells [1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: 4',6-Diamidino-2-phenylindole dihydrochloride (solution). CAS No. 28718-90-3. Pack Sizes: 500 μg (28.55 μM * 50 mL in DDH2O); 5 mg (28.55 μM * 500 mL in DDH2O). Product ID: HY-D0814A. | |
| DAPI dilactate | DAPI (dilactate) is a blue fluorescent dye that preferentially binds dsDNA and binds to minor groove AT clusters. DAPI (dilactate) is combined with dsDNA, and the fluorescence was enhanced about 20-fold. DAPI (dilactate) can be used to identify the cell cycle and specifically stains the nucleus but not the cytoplasm. DAPI (dilactate) form is more soluble in water than DAPI (dihydrochloride) form. [1] [2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: 4',6-Diamidino-2-phenylindole dilactate. CAS No. 28718-91-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D1738. | |
| Dapiglutide | Dapiglutide (ZP7570) is a long-acting glucagon-like peptide-1 receptor 1R (GLP-1R)/Glucagon-like peptide-2 receptor (GLP-2R) dual agonist. Dapiglutide alleviates intestinal dysfunction in a mouse short bowel model and has anti-obesity effects [1] [2] [3]. Uses: Scientific research. Group: Peptides. Alternative Names: ZP7570. CAS No. 2296814-85-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3291. | |
| Dapiprazole hydrochloride | Dapiprazole hydrochloride is a potent, selective and orally active alpha-1 adrenoceptor antagonist. Dapiprazole hydrochloride suppresses the opioid withdrawal symptoms. Dapiprazole hydrochloride is also used as eye drops for reversing mydriasis [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 72822-13-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0142A. | |
| Dapirolizumab | Dapirolizumab is a monoclonal antibodi against CD40 ligand. Dapirolizumab targets CD40L, blocks its interaction with CD40 receptors, and inhibits adaptive immune activation. Dapirolizumab attenuates systemic lupus erythematosus [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 1416147-64-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99842A. | |
| Dapivirine | Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TMC120; R147681. CAS No. 244767-67-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14266. | |
| Dap-NE hydrochloride | Dap-NE hydrochloride is a dipeptide hydrochloride and a cleavable ADC Linker.Dap-NE hydrochloride can be used to connect Antibody and toxin molecules (Cytotoxin) to synthesize Antibody-Drug Conjugates (ADCs) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2019182-02-4. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-78932A. | |
| Daporinad | Daporinad (FK866) is an effective inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with an IC50 of 0.09 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FK866; APO866. CAS No. 658084-64-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50876. | |
| Dapoxetine hydrochloride | Dapoxetine (LY-210448) hydrochloride is an orally active and selective serotonin reuptake inhibitor ( SSRI ). Dapoxetine hydrochloride can be used for the research of premature ejaculation (PE) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY-210448 hydrochloride. CAS No. 129938-20-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0304A. | |
| Daprodustat | Daprodustat (GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor being developed for the treatment of anemia associated with chronic kidney disease. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK1278863. CAS No. 960539-70-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17608. | |
| Dapsone | Dapsone (4,4-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities [1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4,4-Diaminodiphenyl sulfone; DDS. CAS No. 80-08-0. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-B0688. | |
| Dapsone hydroxylamine | Dapsone hydroxylamine (DDS-NOH) induces methemoglobinemia. Dapsone hydroxylamine inhibits catalase (CAT) activity and reactive oxygen species generation. Dapsone hydroxylamine also has anti-inflammatory activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DDS-NOH. CAS No. 32695-27-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-137155. | |
| DAPT | DAPT (GSI-IX) is a potent and orally active γ-secretase inhibitor with IC 50 s of 115 nM and 200 nM for total amyloid-β (Aβ) and Aβ 42 , respectively. DAPT inhibits the activation of Notch 1 signaling and induces cell differentiation. DAPT also induces autophagy and apoptosis. DAPT has neuroprotection activity and has the potential for autoimmune and lymphoproliferative diseases, degenerative disease and cancers treatment [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSI-IX. CAS No. 208255-80-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13027. | |
| DAPTA | DAPTA is a synthetic peptide, functions as a viral entry inhibitor by targeting selectively CCR5 , and shows potent anti-HIV activities. Uses: Scientific research. Group: Peptides. Alternative Names: D-Ala-peptide T-amide; Adaptavir. CAS No. 106362-34-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P1034. | |
| Daptomycin | Daptomycin is a lipopeptide antibiotic with rapid in vitro bactericidal activity against gram-positive organisms. Uses: Scientific research. Group: Peptides. Alternative Names: LY146032. CAS No. 103060-53-3. Pack Sizes: 50 mg; 100 mg. Product ID: HY-B0108. | |
| D-arabinose | D-arabinose is an endogenous metabolite. Uses: Scientific research. Group: Natural products. CAS No. 10323-20-3. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g. Product ID: HY-N0059. | |
| D-?Arabinose | D-Arabinose, a monosaccharide, shows strong growth inhibition against the Caenorhabditis elegans with an IC 50 of 7.5 mM [1]. Uses: Scientific research. Group: Natural products. CAS No. 28697-53-2. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g. Product ID: HY-N7082. | |
| D-Arabitol | D-Arabitol is a polyol and its accumulation may cause a neurotoxic effect in human. Uses: Scientific research. Group: Natural products. CAS No. 488-82-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 1 g. Product ID: HY-N3686. | |
| Darapladib | Darapladib (SB-480848) is an orally active, selective and reversible Lp-PLA2 inhibitor ( IC 50 =0.25 nM). Darapladib can trigger irreversible actions on glioma cell apoptosis and induce cycle arrest. Darapladib can be used in the study of atherosclerosis and cancer [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB-480848. CAS No. 356057-34-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10521. | |
| Daratumumab | Daratumumab (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Anti-Human CD38, Human Antibody. CAS No. 945721-28-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9915. | |
| Daratumumab (PBS) | Daratumumab (PBS) (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab (PBS) has anti-multiple myeloma (MM) effect. Daratumumab (PBS) impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition[1][2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Anti-Human CD38, Human Antibody (PBS). CAS No. 945721-28-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9915A. | |
| Darbufelone mesylate | Darbufelone mesylate (CI-1004 mesylate) is a dual inhibitor of cellular PGF 2α and LTB 4 production. Darbufelone potently inhibits PGHS-2 ( IC 50 = 0.19 μM) but is much less potent with PGHS-1 ( IC 50 = 20 μM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: CI-1004 mesylate. CAS No. 139340-56-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101438A. | |
| Darexaban | Darexaban (YM150) is a potent, selective and orally active factor Xa (FXa) inhibitor with an IC 50 of 54.6 nM. Darexaban shows high selectivity against other related serine proteases, such as trypsin, thrombin, and kallikrein. Darexaban has anticoagulant and antithrombotic effects [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: YM150. CAS No. 365462-23-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14853. | |
| Darifenacin | Darifenacin (UK-88525) is a selective and orally active M3 muscarinic receptor ( M3R ) antagonist with a pKi of 8.9. Darifenacin binds >20-fold more specifically to M3R than to other muscarinic receptors. Darifenacin can be used in the study of urinary incontinence and other symptoms of overactive bladder. Darifenacin inhibits tumor growth in colorectal cancer cells and has anti-tumor effects [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: UK-88525. CAS No. 133099-04-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0033. | |
| (±)-Darifenacin | (±)-Darifenacin is the racemate of Darifenacin. Darifenacin is a selective M3 muscarinic receptor antagonist [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (±)-UK-88525. CAS No. 133033-93-9. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-22437. | |
| Darifenacin hydrobromide | Darifenacin (UK-88525) hydrobromide is a selective and orally active M3 muscarinic receptor ( M3R ) antagonist with a pKi of 8.9. Darifenacin hydrobromide binds >20-fold more specifically to M3R than to other muscarinic receptors. Darifenacin hydrobromide can be used in the study of urinary incontinence and other symptoms of overactive bladder. Darifenacin hydrobromide inhibits tumor growth in colorectal cancer cells and has anti-tumor effects [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: UK-88525 hydrobromide. CAS No. 133099-07-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-A0012. | |
| Darinaparsin | Darinaparsin (ZIO-101), an organic arsenical, is a mitochondrial-targeted agent. Darinaparsin induces apoptosis in ancer cells, and has anticancer effects [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ZIO-101; S-Dimethylarsino-glutathione. CAS No. 69819-86-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-14943. | |
| Darizmetinib | Darizmetinib (HRX-0215) is an orally active, potent and selective inhibitor of mitogen-activated protein kinase kinase 4 (MKK4). Darizmetinib leads to enhancement of the MKK7 and JNK1 signaling pathways, thereby activating the transcription factors ATF2 and ELK1, promoting cell proliferation and liver regeneration. Darizmetinib is promising for research of preventing liver failure after extensive oncological liver resections or transplantation of small liver grafts[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HRX-0215. CAS No. 2369583-33-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-152860. | |
| Darolutamide | Darolutamide (ODM-201;BAY-1841788) is a potent androgen receptor ( AR ) antagonist with an IC 50 of 26 nM in in vitro assay. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ODM-201; BAY-1841788. CAS No. 1297538-32-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16985. | |
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