MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Darovasertib | Darovasertib (LXS196) is a potent, selective and orally active protein kinase C ( PKC ) inhibitor, with IC 50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. Darovasertib has the potential for uveal melanoma research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LXS196; IDE196. CAS No. 1874276-76-2. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101569. |  |
| Darunavir | Darunavir (TMC114), an orally active next generation HIV protease inhibitor, has a similar antiviral activity against the mutant and the wild-type viruses. Darunavir (TMC114) is potent against laboratory HIV-1 strains and primary clinical isolates (IC 50 = 0.003 μM; IC 90 = 0.009 μM) with minimal cytotoxicity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TMC114; UIC-94017. CAS No. 206361-99-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-17040. | |
| Darunavir Ethanolate | Darunavir ethanolate (TMC114 Ethanolate) is a potent HIV protease inhibitor used to treat and prevent HIV/AIDS. Darunavir has a K i of 1 nM for wild type HIV-1 protease. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TMC114 Ethanolate. CAS No. 635728-49-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-17041. | |
| Darusentan | Darusentan (Lu-135252) is a selective endothelin receptor A ( ET-A ) receptor antagonist, which binds with a K i of 1.4 nM to the ET-A receptor and a K i of 184 nM to ET-B receptor, respectively with a 100-fold selectivity for ETA rather than ETB receptors [1]. Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a K i of 13 nM [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Lu-135252. CAS No. 171714-84-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15404. | |
| Darutoside | Darutoside is a diterpenoid isolated from Siegesbeckia [1]. Uses: Scientific research. Group: Natural products. CAS No. 59219-65-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N6028. | |
| DAS-5-oCRBN | DAS-5-oCRBN is a selective and potent PROTAC degrader of c-Src kinase. DAS-5-oCRBN has antiproliferative activity in both c-Src-dependent cell lines[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-163144. | |
| DASA-58 | DASA-58 is a potential pyruvate kinase isozyme (PKM2) allosteric activator. DASA-58 can be used for the research of metabolism and kinds of cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1203494-49-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19330. | |
| Dasabuvir | Dasabuvir (ABT-333) is a nonnucleoside hepatitis C virus (HCV) polymerase inhibitor. Dasabuvir inhibits RNA-dependent RNA polymerase encoded by the HCV NS5B gene. Dasabuvir inhibits genotype 1a (strain H77) and 1b (strain Con1) replicons, with EC 50 values of 7.7 and 1.8 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABT-333. CAS No. 1132935-63-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13998. | |
| Dasatinib | Dasatinib (BMS-354825) is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The K i s are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib inhibits Bcr-Abl and Src with IC 50 s of <1.0 nM and 0.5 nM, respectively [1]. Dasatinib also induces apoptosis and autophagy. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-354825. CAS No. 302962-49-8. Pack Sizes: 10 mM * 1 mL; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10181. | |
| Dasatinib analog-1 | Dasatinib analog-1 (compound 5826) inhibits CYP3A4 viability with a K i value of 5.4 μM. Dasatinib analog-1 blocks the formation of glutathione adducts [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1174416-41-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156883. | |
| Dasatinib-d8 | Dasatinib-d 8 is a deuterium labeled Dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: BMS-354825-d8. CAS No. 1132093-70-9. Pack Sizes: 500 μg; 1 mg. Product ID: HY-10181S. | |
| Dasatinib hydrochloride | Dasatinib (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The K i s are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib hydrochloride inhibits Bcr-Abl and Src with IC 50 s of <1.0 nM and 0.5 nM, respectively [1]. Dasatinib hydrochloride also induces apoptosis and autophagy. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-354825 hydrochloride. CAS No. 854001-07-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-10181A. | |
| Dasatinib metabolite M6 | Dasatinib metabolite M6 (Dasatinib carboxylic acid) is an oxidative metabolite of Dasatinib (HY-10181). Dasatinib is a potent and orally active dual Bcr-Abl and Src family tyrosine kinase inhibitor[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Dasatinib carboxylic acid. CAS No. 910297-53-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131669. | |
| Dasatinib monohydrate | Dasatinib (BMS-354825) monohydrate is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The K i s are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib monohydrate inhibits Bcr-Abl and Src with IC 50 s of <1.0 nM and 0.5 nM, respectively [1]. Dasatinib monohydrate also induces apoptosis and autophagy. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-354825 monohydrate. CAS No. 863127-77-9. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-10181B. | |
| Dasatinib N-oxide | Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 910297-52-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-133794. | |
| Dasminapant | Dasminapant (APG-1387), a bivalent SMAC mimetic and an IAP antagonist, blocks the activity of IAPs family proteins (XIAP, cIAP-1, cIAP-2, and ML-IAP). Dasminapant induces degradation of cIAP-1 and XIAP proteins, as well as caspase-3 activation and PARP cleavage, which leads to apoptosis. Dasminapant can be used for the research of hepatocellular carcinoma, ovarian cancer, and nasopharyngeal carcinoma[1][2][3][4][5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: APG-1387. CAS No. 1570231-89-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-125593. | |
| Dasotraline hydrochloride | Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine , norepinephrine , and serotonin transporters with IC 50 values of 4, 6, and 11 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SEP-225289 hydrochloride. CAS No. 675126-08-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12850A. | |
| D-Asparagine | D-Asparagine (H-D-Asn-OH) is a competitive inhibitor of L-Asparagine hydrolysis with a K i value of 0.24 mM. D-Asparagine is a source of nitrogen for yeast strains. D-Asparagine is a good substrate for the external yeast asparaginase but is a poor substrate for the internal enzyme [1]. Uses: Scientific research. Group: Natural products. Alternative Names: H-D-Asn-OH. CAS No. 2058-58-4. Pack Sizes: 10 mM * 1 mL; 1 g. Product ID: HY-W010378. | |
| Datelliptium chloride | Datelliptium chloride is a DNA-intercalating agent derived from ellipticine, with anti-tumor activities. Uses: Scientific research. Group: Signaling pathways. CAS No. 105118-14-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00337. | |
| Datopotamab | Datopotamab (CDP7657) is a humanized anti trophoblast cell surface antigen 2 ( TROP2 ) antibody. Datopotamab can generate antibody drug conjugates (ADC) (HY-141598) with DNA topoisomerase I inhibitor Deruxtecan (HY-13631E). Datopotamab can be used in the study of triple negative breast cancer and non-small cell lung cancer [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2267989-53-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99843. | |
| Datopotamab deruxtecan | Datopotamab deruxtecan (DS-1062; Dato-DXd) is a trophoblast cell surface antigen 2 (TROP2)-directed antibody-drug conjugate (ADC). Datopotamab deruxtecan has a potent antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DS-1062; Dato-DXd. CAS No. 2238831-60-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-141598. | |
| Daucosterol | Daucosterol is an orally active natural sterol compound, which has anti-inflammatory, anticancer and immunomodulatory activities. Daucosterol inhibits cancer cell proliferation by inducing autophagy through ROS-dependent manner. Daucosterol also inhibits colon cancer growth by inducing apoptosis, inhibiting cell migration and invasion and targeting caspase signalling pathway [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Eleutheroside A; β-Sitosterol β-D-glucoside. CAS No. 474-58-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-N0410. | |
| DAUDA | DAUDA (11-(dansylamino) undecanoic acid) is an environment-sensitive fluorescent fatty acid analogue. DAUDA alters its intensities and fluorescent emission spectra on entry into binding proteins. DAUDA is used to determine the relative affinity of natural fatty acids for polymorphs of the Schistosoma mansoni Sm14 fatty acid-binding protein[1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 73025-02-2. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-120959. | |
| Daunomycinone | Daunomycinone (NSC-109351) is a metabolite of daunomycin. Daunomycin is an antibiotic with antitumor activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC-109351. CAS No. 21794-55-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114658. | |
| Daunorubicin hydrochloride | Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor [1] [2] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride. CAS No. 23541-50-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13062. | |
| Dauricine | Dauricine, a bisbenzylisoquinoline alkaloid in Menispermum dauricum , possesses anti-inflammatory activity. Dauricine inhibits cell proliferation and invasion, and induces apoptosis by suppressing NF-κB activation in a dose- and time-dependent manner in colon cancer [1]. Uses: Scientific research. Group: Natural products. CAS No. 524-17-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N0220. | |
| DavePhos | DavePhos is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 213697-53-1. Pack Sizes: 1 g; 5 g; 10 g. Product ID: HY-W002925. | |
| Davunetide | Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity [1] [2] [3]. Uses: Scientific research. Group: Peptides. CAS No. 211439-12-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-105066. | |
| Davutamig | Davutamig (REGN-5093) is a humanIgG4-kappa, anti-MET bispecific antibody targeting two different nonoverlapping epitopes on MET. Davutamig is an antineoplastic agent [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: REGN-5093. CAS No. 2648058-48-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990073. | |
| Daxdilimab | Daxdilimab is an anti-ILT7 monoclonal antibody, ILT7 is a cell surface molecule specific to the pDC type of dendritic cells. Daxdilimab can be used in acute lung injury (ALI) in patients with COVID-19 infection research [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MEDI7734; VIB7734. CAS No. 2245966-28-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99226. | |
| Dazodalibep | Dazodalibep (MEDI 4920; VIB 4920) is a fusion protein targeting CD40LG/TNFSF5 fused to human serum albumin ALB/HSA [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MEDI 4920; VIB 4920. CAS No. 2245953-10-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99845. | |
| Dazostinag disodium | Dazostinag disodium (TAK-676) is an agonist of STING, triggering the activation of STING signaling pathway and type I interferons. Dazostinag disodium is also a modulator of immune system, resulting complete regressions and durable memory T-cell immunity. Dazostinag disodium promotes durable IFN-dependent antitumor immunity[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TAK-676. CAS No. 2553413-93-5. Pack Sizes: 100 ?g; 500 ?g; 1 mg; 5 mg; 10 mg. Product ID: HY-148029. | |
| Dazoxiben hydrochloride | Dazoxiben hydrochloride is a potent and orally active thromboxane (TX) synthase inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: UK 37248. CAS No. 74226-22-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106067A. | |
| Dazucorilant | Dazucorilant (CORT113176) is a selective and high affinity non-steroidal glucocorticoid receptor ( GR ) modulator with a K i value ?1 nM in vitro. Dazucorilant can be used for the research of neurological disorders [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CORT113176. CAS No. 1496508-34-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-132811. | |
| Dazukibart | Dazukibart is a mouse-derived, humanized IgG1κ antibody targeting interferon beta 1 ( IFNB1 ) [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2639474-65-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990036. | |
| DB18 | DB18 is a potent and selective inhibitor of CDC2-like kinases (CLKs) , with IC 50 values in the range of 10-30 nM for CLK1, CLK2 and CLK4. DB18 has anti-tumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2587177-94-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-131978. | |
| DB1976 dihydrochloride | DB1976 dihydrochloride is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 dihydrochloride potently inhibits PU.1 binding (IC50 of 10 nM) and strongly inhibits the PU.1/DNA complex (with high DB1976-?B affinity, KD of 12 nM) in vitro. DB1976 dihydrochloride has apoptosis-inducing effect[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2369663-93-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-135797A. | |
| DB2115 tertahydrochloride | DB2115 (tertahydrochloride) is a potent inhibitor of myeloid master regulator PU.1. DB2115 (tertahydrochloride) has the potential for researching cancers, including hematologic cancers such as leukemia, as well as other conditions associated with PU. 1 dysfunction (extracted from patent WO2017223260A1, compound DB2115) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1366126-19-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124676A. | |
| DB2313 | DB2313 is a potent inhibitor of transcription factor PU.1. DB2313 inhibits PU.1-dependent reporter gene transactivation with an IC50 of 5 ?M. DB2313 disrupts the interaction of PU.1 with target gene promoters. DB2313 induces apoptosis in acute myeloid leukemia (AML) cells and has anticancer effects[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2170606-74-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-124629. | |
| DB28 | DB28 is a novel MR1 ligand. DB28 decreases cell surface expression of MR1 and competitively inhibits activation of MAIT cells by agonist ligands [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 16296-42-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W168754. | |
| DB775 | DB775 is a metabolite of DB289 (HY-14932) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 475976-08-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-164025. | |
| DB818 dihydrochloride | DB818 dihydrochloride is the dihydrochloride salt form of DB818 (HY-122623). DB818 dihydrochloride is an inhibitor for Homeobox A9 (HOXA9). DB818 dihydrochloride reduces the formation of HOXA9-DNA complexes, inhibits the growth and induces apoptosis in AML cell lines OCI/AML3, MV4-11, and THP-1[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 1 mg; 5 mg. Product ID: HY-122623A. | |
| DBCO-acid | DBCO-acid is a click chemistry reagent used in the synthesis of ADC linker DBCO-NHS ester (HY-115524 and HY-115545), and agent-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690). DBCO-acid contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1353016-70-2. Pack Sizes: 10 mg; 50 mg; 100 mg. Product ID: HY-42972. | |
| DBCO-amine | DBCO-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. DBCO-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1255942-06-3. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-W000423. | |
| DBCO-Biotin | DBCO-Biotin is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs [1]. DBCO-Biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1418217-95-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123916. | |
| DBCO-Cy3 | DBCO-Cy3 (DBCO-Sulfo-Cy3) is the derivative of Cyanine3 fluorophore, a pH insensitive from pH (4-10) orange fluorescent dye with excitation maximum 555 nm and emission maximum of 580nm. DBCO-Cy3 has fast reaction kinetics and good stability, and is productive to use in many standard fluorescent instrumentations. DBCO-Cy3 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: DBCO-Sulfo-Cy3. CAS No. 1782950-79-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-D1069. | |
| DBCO-Maleimide | DBCO-Maleimide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. DBCO-Maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1395786-30-7. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-116270. | |
| DBCO-NHS ester | DBCO-NHS ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. DBCO-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1353016-71-3. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-42973. | |
| DBCO-NHS ester 2 | DBCO-NHS ester 2 is a cleavable linker that is used for making antibody-drug conjugate (ADC). DBCO-NHS ester 2 is a derivative of Dibenzylcyclooctyne (DBCO) used in copper-free click chemistry[1]. DBCO-NHS ester 2 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1384870-47-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115524. | |
| DBCO-PEG12-NHS ester | DBCO-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG12-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2093934-94-0. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-140274. | |
| DBCO-PEG2-NHS ester | DBCO-PEG2-NHS ester is a click chemistry reagent containing an azide group. DBCO-PEG2-NHS ester is a click chemistry PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research use only [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2585653-12-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-151827. | |
| DBCO-PEG3-NHS ester | DBCO-PEG3-NHS ester (cpmpd 45) is a ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2163772-16-3. Pack Sizes: 25 mg; 50 mg. Product ID: HY-156507. | |
| DBCO-PEG3-VC-Exatecan | DBCO-PEG3-VC-Exatecan (compound 25) is a Drug-Linker Conjugate for ADC. DBCO-PEG3-VC-Exatecan contains the ADC linker (DBCO-PEG3-VC) and a DNA topoisomerase I inhibitor Exatecan (HY-13631)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2754384-70-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-164792. | |
| DBCO-PEG4-Biotin | DBCO-PEG4-Biotin is an azadibenzocyclooctyne-biotin derivative containing a biotin group and 4 PEGs. DBCO-PEG4-Biotin is a versatile biotinylation reagent used for the introduction of a biotin moiety to azide-labeled biomolecules via copper-free strain-promoted alkyne-azide click chemistry (SPAAC) reaction [1]. DBCO-PEG4-Biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1255942-07-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-130809. | |
| DBCO-PEG4-DBCO | DBCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. DBCO-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2182601-68-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-130346. | |
| DBCO-PEG4-Desthiobiotin | DBCO-PEG4-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. DBCO-PEG4-Desthiobiotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2032788-37-5. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-140301. | |
| DBCO-PEG4-Eosin 5-isothiocyanate | DBCO-PEG4-Eosin 5-isothiocyanate is a fluorescent probe. DBCO-PEG4-Eosin 5-isothiocyanate contains a clickable functional group, DBCO, and four PEG units. DBCO-PEG4-Eosin 5-isothiocyanate can be used for various imaging detections[1]. Uses: Scientific research. Group: Fluorescent dye. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-159529. | |
| DBCO-PEG4-GGFG-Dxd | DBCO-PEG4-GGFG-Dxd is a agent-linker conjugate for ADC with potent antitumor activity by using Dxd (a DNA topoisomerase I inhibitor), linked via the cleavable ADC linker DBCO-PEG4-GGFG[1]. DBCO-PEG4-GGFG-Dxd is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2694856-51-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134723. | |
| DBCO-PEG4-Maleimide | DBCO-PEG4-Maleimide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. DBCO-PEG4-Maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1480516-75-3. Pack Sizes: 25 mg. Product ID: HY-120770. | |
| DBCO-PEG4-NHS ester | DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG4-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1427004-19-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-140272. | |
| DBCO-PEG4-Val-Cit-PAB-MMAF | DBCO-PEG4-Val-Cit-PAB-MMAF consists a cleavable 4 unit PEG ADC linker (DBCO-PEG4-Val-Cit-PAB) and a potent tubulin polymerization inhibitor (MMAF). DBCO-PEG4-Val-Cit-PAB-MMAF can be used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-PEG4-Val-Cit-PAB-MMAF is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2244602-23-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-130990. | |
| DBCO-PEG4-VA-PBD | DBCO-PEG4-VA-PBD is a agent-linker conjugate for ADC by using the antitumor antibiotic, Pyrrolobenzodiazepine (PBD), linked via DBCO-PEG4-VA[1]. DBCO-PEG4-VA-PBD is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2241644-09-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-133433. | |
| DBCO-PEG4-VC-PAB-MMAE | DBCO-PEG4-VC-PAB-MMAE consists a ADC linker (DBCO-PEG4-VC-PAB) and a tubulin polymerization inhibitor MMAE (HY-15162). DBCO-PEG4-VC-PAB-MMAE can be used in the synthesis of antibody-agent conjugates (ADCs). MMAE is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. DBCO-PEG4-VC-PAB-MMAE is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2129164-91-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136314. | |
| DBCO-PEG5-NHS ester | DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1] [2]. DBCO-PEG5-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2144395-59-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126885. | |
| DBCO-Sulfo-Link-biotin | DBCO-Sulfo-Link-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. DBCO-Sulfo-Link-biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1363444-70-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-130810. | |
| DBCO-Sulfo-Link-biotin TEA | DBCO-Sulfo-Link-biotin TEA is a click chemistry intermediate containing a DBCO group, which can undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group. Uses: Scientific research. Group: Signaling pathways. CAS No. 1485489-28-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-W123019. | |
| DBCO-Sulfo-NHS ester sodium | DBCO-Sulfo-NHS ester sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. DBCO-Sulfo-NHS ester (sodium) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Group: Fluorescent dye. CAS No. 1400191-52-7. Pack Sizes: 5 mg. Product ID: HY-123687. | |
| DBCO-Val-Cit-PAB-MMAE | DBCO-Val-Cit-PAB-MMAE is a drug-linker conjugate, which can be used for the synthesis of ADC molecules. MMAE (HY-15162) is a tubulin inhibitor, which can be used as an ADC toxin. DBCO-Val-Cit-PAB is the linker with the electrophilic group [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2768446-73-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-W591408. | |
| DBeQ | DBeQ is a selective, potent, reversible, and ATP-competitive p97 inhibitor, with an IC 50 value of 1.5 μM and 1.6 μM for p97(wt) and p97(C522A), respectively; DBeQ also inhibits Vps4 with an IC 50 of 11.5 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: JRF 12. CAS No. 177355-84-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15945. | |
| dBET1 | dBET1 is a PROTAC connected by ligands for Cereblon and BRD4 with an EC50 of 430 nM. dBET1 is a PROTAC that composes of (+)-JQ1 (HY-13030) linked to NSC 527179 (HY-14658) with a linker[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1799711-21-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101838. | |
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