USBiological 4 - Products
Worldwide
Our biochemicals, antibodies, recombinant proteins, cell culture media and molecular biology kits are used in virtually all scientific applications.From affordable research quantities to larger bulk amounts.
| Product | Description | |
|---|---|---|
| Sarcosine-13C3 | Sarcosine-13C3 is a labelled analogue of Sarcosine (S140500), a type 1 glycine transporter inhibitor and a glycine agonist that may be useful for treating schizophrenia (1). Sarcosine is also a marker for prostate cancer bioagression (2). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: 13C3H7NO2. US Biological Life Sciences. |  Worldwide |
| (S)-(+)-Ascochin ((S)-6,8-Dihydroxy-4-methyl-3-methylene-1-oxoiso-chroman-5-carbaldehyde) | Antibiotic. Antifungal and phytotoxic. Group: Biochemicals. Grades: Highly Purified. CAS No. 935699-58-4. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Sauchinone (1?-Epimer dihydrocarpanone) | Hepatoprotective antioxidant. Anti-inflammatory. Suppresses NF-kB p65 activity. Neuroprotective. Apoptosis inhibitor. Bone resorption / osteoclastogenesis inhibitor. Reduces ROS formation. Antiseptic. AMP-activated kinase (AMPK) activator. Akt phosphorylation inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 177931-17-8. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| SB 206553 Hydrochloride (5-HT2C Serotonin Receptor Antagonist, SB 206553, 5-HT2B Serotonin Receptor Antagonist, SB 206553, SB206553, SB-206553) | A selective 5-HT2C serotonin receptor inhibitor with lesser affinity for 5-HT2BR. Often used in conjunction with ketanserin to distinguish 5-HT2AR and 5-HT2CR activity. SB206553 has highest affinity for 5-HT2CR (Ki = 3.2nM) and less for 5-HT2BR (Ki = 5.5nM) and 5-HT2AR (Ki = 2,300nM). Group: Biochemicals. Grades: Highly Purified. CAS No. 158942-04-2. Pack Sizes: 10mg. Molecular Formula: C??H??N?O·HCl. US Biological Life Sciences. | Worldwide |
| SB 242084 Hydrochloride (5-HT2C Receptor Antagonist, SB 242084 Hydrochloride, SB-242084 Hydrochloride, SB242084 Hydrochloride) | A selective, brain-penetrant 5-HT2C receptor antagonist (pKi 8.2-9.0 ), with some effects on the 5-HT2B receptor (pKi 6.8-7.0) and 5-HT2A receptor (pKi 6.1-6.8). SB 242084 has been shown to increase the effectiveness of the selective serotonin reuptake inhibitor (SSRI) class of antidepressants, and may also reduce their side effects. In animal studies, SB-242,084 produced stimulant-type activity and reinforcing effects, somewhat similar to but much weaker than cocaine or amphetamines. In vivo (ocular) IC50 values reported at 2.08uM. Group: Biochemicals. Grades: Highly Purified. CAS No. 181632-25-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SB-269970 Hydrochloride (5-HT7 Serotonin Receptor Antagonist, SB-269970, SB 26,970, SB 26,970) | A selective 5-HT7 receptor antagonist. Extremely potent in vivo and in vitro. Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT7 receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT7 antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B). Group: Biochemicals. Grades: Highly Purified. CAS No. 261901-57-9. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S·HCl. US Biological Life Sciences. | Worldwide |
| SB-277011-A Dihydrochloride (SB277011A, SB 277011A, Dopamine D3 Receptor Antagonist, SB-277011-A, SB-277011A) | A brain-penetrant, high-affinity, and selective dopamine D3 receptor antagonist. High affinity for the hD3 receptor (pKi = 7.95) with 100-fold selectivity over the hD2 receptor and over 66 other receptors, enzymes, and ion channels. Rat data shows that the compound is selective for the D3 receptor over certain serotonergic and cholinergic receptors at doses up to 56mg/kg and strong physiological response at 32mg/kg. Group: Biochemicals. Grades: Highly Purified. CAS No. 1226917-67-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| SB 399885 Hydrochloride (5-HT6 Receptor Antagonist, SB 399885) | A high affinity 5-HT6 Receptor antagonist (pKi = 9.0). Good solubility (to 100mM in water or DMSO), oral availability, and penetrant to blood brain barrier. Over 200-fold selective for 5-HT6 receptors vs all receptors, ion channels and enzymes tested in Hirst et al. 2006 publication. Shows nootropic, antidepressant and axiolytic effects comparable to well-described drugs such as diazepam, and therefore has been proposed as novel treatment for schizoprenia and Alzheimers disease. Group: Biochemicals. Alternative Names: N- (3, 5-Dichloro-2-methoxyphenyl) -4-methoxy-3- (1-piperazinyl) benzenesulfonamide Hydrochloride; SB 399885 Monohydrochloride. Grades: Highly Purified. CAS No. 402713-80-8. Pack Sizes: 10mg, 25mg, 50mg. US Biological Life Sciences. | Worldwide |
| SB 699551 Dihydrochloride (5-HT5A Serotonin Receptor Antagonist, SB 699551, SB 699551, SB699551, SB-699551) | A selective, brain penetrant, 5-HT5A receptor antagonis (pKi = 8.2). Competitively antagonised 5-HT-stimulated [35S]GTP-gamma-S binding to membranes from human embryonic kidney (HEK293) cells transiently expressing the guinea pig 5-HT5A receptor (pA2 8.1 ± 0.1) and displayed 100-fold selectivity versus the serotonin transporter and those 5-HT receptor subtypes (5-HT1A/B/D, 5-HT2A/C and 5-5-HT7). Group: Biochemicals. Grades: Highly Purified. CAS No. 791789-61-2. Pack Sizes: 10mg. Molecular Formula: C??H??N?O·2HCl. US Biological Life Sciences. | Worldwide |
| SBHA (Suberohydroxamic acid, Suberic bis-hydroxamic acid, N, N'-dihydroxyoctane diamide) | SBHA is a competitive histone deacetylase (HDAC) inhibitor that has been shown to inhibit HDAC1 (IC50=0.25uM) and HDAC3 (IC50=0.30uM). SBHA causes cell differentiation, cell cycle arrest, or apoptosis. SBHA also enhances cytotoxicity induced by Oxaliplatin in the colorectal cancer cell lines. Group: Biochemicals. Grades: Highly Purified. CAS No. 38937-66-5. Pack Sizes: 50mg, 250mg. US Biological Life Sciences. | Worldwide |
| SC66, Akt Inhibitor XVIII ( (2E, 6E) -2, 6-bis (4-Pyridylmethylene) cyclohexanone) | A cell-permeable pyridine compound that selectively targets Akt, but not PLCd, PH domain, preventing Akt membrane localization / activation and rendering Akt in a conformation susceptible to ubiquitination and subsequent proteasomal degradation. Akti-1/2 competes for Akt PH domain binding and blocks SC66-induced Akt ubiquitination and proteasomal degradation. Effectively inhibits HEK293T growth both in vitro (>99 inhibition at 0.4uM) and in mice in vivo (84% of control tumor size with twice weekly i.p. dose of 30mg/kg), Synergizes with LY294002 in cell death induction in HeLa and HS-Sultan cultures in vitro. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??N?O, Molecular Weight: 276.3. US Biological Life Sciences. | Worldwide |
| SCH 23390 Hydrochloride (Dopamine Receptor D1/D5 Antagonist, SCH 23390, (R)-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine Hydrochloride, SCH23390, SCH-23390) | A highly potent and selective dopamine D1-like receptor antagonist with a Ki of 0.2 and 0.3nM for the D1 and D5 dopamine receptor subtypes, respectively. Also an agonist at 5-HT1C and 5-HT2C receptors in vitro (Ki values are 6.3nM and 9.3nM respectively). Group: Biochemicals. Grades: Highly Purified. CAS No. 125941-87-9. Pack Sizes: 10mg. Molecular Formula: C??H??ClNO HCl. US Biological Life Sciences. | Worldwide |
| Scriptaid | A relatively non-toxic Inhibitor of histone deacetylase (HDAC). Facilitates transcriptional activation (TGF-b/Smad4) in both stable and transient receptor assays in a concentration-dependent manner. At ~2ug/ml (6-8uM) concentrations, results in a greater than 100-fold increase in histone acetylation in PANC-1 cells. Group: Biochemicals. Alternative Names: N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide. Grades: Highly Purified. CAS No. 287383-59-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Selenium Shot | Selenium Shot is used in selenium-derived drugs like selenate, selenite, selenomethionine, methyl-selenocysteine (MSC), and methaneselenic acid (MSA), that exhibits anticancer properties clinically by sensitizing p-glycoprotein (p-gp)-overexpressing resistant KBV20C cancer cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 7782-49-2. Pack Sizes: 5g, 25g. Molecular Formula: Se, Molecular Weight: 78.9599999999999. US Biological Life Sciences. | Worldwide |
| Serum Amyloid P Component, Control (SAP) | Serum Amyloid P Component, Control (SAP). Group: Molecular Biology. Pack Sizes: 15ul. US Biological Life Sciences. | Worldwide |
| Setomimycin | 9,9`-Bianthryl polyketide derivative. Antibiotic. Active against Gram-positive bacteria including mycobacteria. Bacterial cell wall synthesis inhibitor. Antitumor compound. Group: Biochemicals. Alternative Names: Setomimicin, AM-2947, Antibiotic A 39183B, BRN 5202658, 1, ?1-?Diacetyl-?2, ?3-?dihydro-?2, ?5, ?5, ?10, ?10-?pentahydroxy-?2, ?2-?dimethyl-[9, ?9-?bianthracene]?-?4, ?4(1H, ?1H)?-?dione. Grades: Highly Purified. CAS No. 69431-87-4. Pack Sizes: 1mg. Molecular Formula: C??H??O? , Molecular Weight: 580.6. US Biological Life Sciences. | Worldwide |
| SHIP1 Inhibitor, 3AC (SH2-domain-containing inositol 5-phosphatase 1 (SHIP1) Inhibitor, 3AC, 3a-Aminocholestane) | A cell-permeable steroidal compound that acts as a highly selective SHIP1 activity inhibitor (IC50=10uM) over SHIP2 and PTEN (IC50>1mM in a phosphate release assay). Shown to boost the number of myeloid immunoregulatory cells and circulating granulocytes, and facilitate blood cell recovery in myelosuppressed hosts (60uM, i.p. in mice). Also, promotes apoptosis and reduces SHIP1-expressing KG1 and C1498 cell growth. SHIP2 Inhibitor, AS1938909 is also available. Group: Biochemicals. Grades: Highly Purified. CAS No. 2206-20-4. Pack Sizes: 10mg. Molecular Formula: C??H??N. US Biological Life Sciences. | Worldwide |
| SHIP2 Inhibitor, AS1938909 (3- (2, 4-Dichlorobenzyl) oxy]-N- (2, 6-difluorobenzyl) thiophene-2-carboxamide, SH2 Domain-containing Inositol 5-phosphatase 2 (SHIP2) Inhibitor) | A cell-permeable thiophenecarboxamide compound that is shown to increase glucose metabolism and activate intracellular insulin signaling. Acts as a potent, competitive and reversible inhibitor of SHIP2 activity (Ki=0.44uM for hSHIP2) with moderate to excellent selectivity over SHIP1 and other related phosphatases (IC50=0.18, 0.57, 21, >50, >50 and >50uM for mSHIP2, hSHIP2, hSHIP1, hPTEN, h-synaptojanin and h-myotubularin, respectively). Elevates insulin-induced pAkt-Ser473 levels and enhances glucose transporter GLUT1 mRNA expression in L6 myotubes. SHIP1 Inhibitor, 3AC is also available. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SHIP2 Inhibitor II, CPDA | A cell-permeable aminopyridine acetamide based compound that acts as an inhibitor of SH2 domain-containing inositol 5-phosphatase 2 (SHIP2) that can overcome insulin resistance in 3T3-L1 adipocytes. Enhances insulin-stimulated Akt phosphorylation (Thr308) in TNFa-treated 3T3-L1 adipocytes (~10uM) and in primary cultured neurons from rat cerebral cortex. Improves glucose tolerance in db/db mice (~300mg/kg b.i.d) without affecting their fasting glucose levels. Also reduces the expression levels of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??ClF?N?O?, Primary Target: SHIP2. US Biological Life Sciences. | Worldwide |
| Simocyclinone D8 | Antibiotic. Bacterial DNA gyrase inhibitor: Staphylococcus aureus (IC50=1.45uM), E. coli (IC50=0.41uM). Human topoisomerase II (Topo II) inhibitor (IC50=100uM). Antibacterial (Gram-positive). Antitumor compound. Group: Biochemicals. Grades: Highly Purified. CAS No. 301845-97-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| SIRT1/2/3 pan Inhibitor (pan SIRT1/2/3 Inhibitor, 4- (4- (2-Pivalamidoethyl) piperidin-1-yl) thieno[3, 2-d]pyrimidine-6-carboxamide) | A thienopyrimidinyl carboxamide that acts as a highly potent, reversible pan sirtuin (SIRT) inhibitor (IC50 = 15, 10, and 33nM for SIRT1, 2, and 3, respectively). Shown to bind to the SIRT catalytic site and occupy both the nicotinamide C-pocket and acetyl lysine substrate channel. Exhibits high selectivity over a panel of protein kinases, nuclelar receptors, GPCRs, and ion-channels (IC50 > 10uM). Poorly affects hERG and cytochrome P450s (> 50uM). Exhibits desirable stability in microsomal preparations (human CLint = 15.8 uL/min/mg, mouse CLint = 12.7uL/min/mg) and high solubility (297uM), and low LogD (2.73). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
| SIRT1 Activator II (3- (Benzenesulfonyl) -1- (4-fluorophenyl) pyrrolo[4, 5-b]quinoxalin-2-amine) | A cell-permeable pyrroloquinoxaline compound that acts as a reversible SIRT1 activator (10uM causes ~2.3-fold fluorescent enhancement in a fluorescent assay using hrSIRT1) and enhances fat mobilization in fully differentiated 3T3L1 fibroblasts. Shown to inhibit LPS-induced TNF-a release in THP-1 cells by ~10-fold more potent than resveratrol. Group: Biochemicals. Grades: Highly Purified. CAS No. 374922-43-7. Pack Sizes: 10mg. Molecular Formula: C??H??FN?O?S, Molecular Weight: 418.4. US Biological Life Sciences. | Worldwide |
| Sirtinol (SIRT2 Inhibitor Naphthol) | Cell-permeable. A selective sirtuin deacetylase inhibitor with IC50 values of 38, 68 and 131uM for SIRT2, Sir2p and SIRT1 respectively. Sirtinol has no effect on HDAC1 activity. Sirtinol inhibits the growth of cancer cells and suppresses inflammatory signaling in human dermal microvascular endothelial cells. Group: Biochemicals. Alternative Names: 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide. Grades: Highly Purified. CAS No. 410536-97-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Sirtuin-3 Inhibitor, SRT1720 (SIRT3 Inhibitor II, N- (2- (3- (1-Piperazinylmethyl) imidazo[2, 1-b]thiazol-6-yl) phenyl) -2-quinolinecarboxamide) | A cell-permeable quinolinecarboxamide compound that is shown to inhibit the mitochondrial SIRT3 in a substrate AceCS2-competitive (Ki = 0.56uM; Km = 2.44uM), but NAD+-uncompetitive (Ki = 0.34uM; Km = 280uM), manner. Also reported to decrease cellular p53 Lys382 acetylation (Effective conc. = 10uM in U2OS and MEF cultures) and inhibit p300 HAT activity (IC50 = 9uM) in vitro, as well as offer therapeutic benefits in several murine and rodent type 2 diabetes models (100mg/kg/dayl p.o.) in vivo. Whether and how SRT1720 activates SIRT1 activity remains uncertain. Group: Biochemicals. Grades: Highly Purified. CAS No. 925434-55-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Sitagliptin Phosphate Monohydrate (7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate, MK-0431) | An anti-diabetic (antihyperglycemic) drug of the dipeptidyl peptidase-4 (DPP-4) class. Inhibition of the enzyme DPP-4 is thought to increase Glucagon-like peptide-1 (GLP-1) which inhibits glucagon release, stimulates the insulin release and lowers blood glucose. Group: Biochemicals. Grades: Highly Purified. CAS No. 654671-77-9. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| (S)-Ketamine-d6 Hydrochloride | (S)-Ketamine-d6 Hydrochloride is labelled (S)-Ketamine (K165310, HCl salt) which is the more active enantiomer of the NMDA receptor antagonist and anesthetic agent Ketamine (K165300). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C13H11D6Cl2NO. US Biological Life Sciences. | Worldwide |
| Skullcapflavone II | Skullcapflavone II is derived from Scutellaria baicalensis, inhibitis ovalbumin-induced airway inflammation in a mouse model of asthma. Group: Biochemicals. Grades: Highly Purified. CAS No. 55084-08-7. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C19H18O8, Molecular Weight: 374.34. US Biological Life Sciences. | Worldwide |
| (S)-MCPG ((S)-alpha-Methyl-4-carboxyphenylglycine, Group I/II mGlu Antagonist, (S)-MCPG) | A non-selective antagonist for group I/II mGlu receptors (minimal values of IC50 reported = 40 and 15uM for mGlu1 and mGlu2, respectively). Often used as an agent to differentiate excitatory neurotransmissions mediated by glutamate from other neurotransmitters (i.e. dopamine, acetylcholine, and GABA in early brain development). A common component of cocktails for blocking glutamate transmission in brain slice preparation. Group: Biochemicals. Grades: Highly Purified. CAS No. 150145-89-4. Pack Sizes: 10mg. Molecular Formula: C??H??NO?. US Biological Life Sciences. | Worldwide |
| SMI-4a (5E/Z) -[[3- (Trifluoromethyl) phenyl]methylene]-2, 4-thiazolidinedione) | A selective, ATP-competitive inhibitor Pim-1 (IC50=21nm) and Pim-2 (IC50=100nm) protein kinases. Blocks mTORC1 activity via activation of AMPK. SMI-4a has been found to inhibit prostate cancer cell growth and induce G1 phase cell-cycle arrest in precursor T-cell lymphoblastic leukemia/lymphoma cell lines. Group: Biochemicals. Grades: Highly Purified. CAS No. 327033-36-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Smo Antagonist, SA10 (4- ( (Benzo [c] [1, 2, 5] thiadiazole-4-sulfonamido) methyl -N- (3-phenylpropyl ) cyclohexane carboxamide) | SA10 inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC50 = 5uM). However, unlike SA1 and SA9, Smo antagonist SA10 does not directly bind to Smo. Inhibits the localization o Smo to cilia. Also treatment of Ptch1-/- MEFs with SA10 suppresses the beta-galactosidase activity (IC50 = 11.0uM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg, 5mg. US Biological Life Sciences. | Worldwide |
| Smo Antagonist, SA1 (3-(3-(4-Fluorophenyl)-2, 5, 7-trimethylpyrazolo[1, 5a]pyrimidin-6-yl)-N-(4-(furan-2-yl)butan-2-yl)propanamide) | A Smoothened (Smo) antagonist. SA1 inhibits Hh pathway by interacting directly with Smo. Inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC50 = 3.1uM). Also inhibits the localization of Smo to cilia. Treatment of Ptch1-/- MEFs with SA1 suppresses the b-galactosidase activity (IC50 = 3.8uM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg, 5mg. US Biological Life Sciences. | Worldwide |
| Smo Antagonist, SA9 (3- (3- (4-Fluorophenyl) -5-oxo-4, 5-dihydro-[1, 2, 4]triazolo[4, 3-a]quinazolin-1-yl-N- (3-methylphenethyl) propanamide) | SA9 inhibits Hh pathway by interacting directly with Smo. It inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC50 =19um). Induces the localization of Smo to cilia in ASZ1 cells, but not in IMCD3 cells. Also treatment of Ptch1-/- MEFs with SA9 suppresses the b-galactosidase activity (IC50 =1.0um) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg, 5mg. US Biological Life Sciences. | Worldwide |
| Smoothened Agonist, SAG (N-Methyl-N- (3-pyridinylbenzyl) -N- (3-chlorobenzo [b]thiophene-2-carbonyl) -1, 4-diaminocyclohexane, SAG1.3 ) | A cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (=59nM). Shown to induce Smo internalization. Shown to induce Hedgehog pathway activation (EC50= ?3nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations. Group: Biochemicals. Grades: Highly Purified. CAS No. 364590-63-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| SNC80 (Delta Opioid Receptor Agonist, SNC80) | A very potent and selective delta opioid receptor agonist (IC50 = 0.32uM). Shown to induce dose- and time-dependent antinociception after i.c.v., i.th. and i.p. administration in mice. Widely used in studies of depression and inflammatory injuries. It is also reported to be acted upon heteromeric u-d receptors. Group: Biochemicals. Grades: Highly Purified. CAS No. 156727-74-1. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| SOD1 Inhibitor, LCS-1 (4,5-dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone, 4,5-dichloro-2-m-tolylpyridazin-3(2H)-one, Superoxide Dismutase 1 Inhibitor, Lung Cancer Screen 1) | A 2-phenylpyridazin-3(2H)-one based non-copper chelater that selectively inhibits the activity of Superoxide dismutase 1 (Cu/Zn-SOD) (IC50=1.07uM). Cells over-expressing SOD1 show reduced sensitivity to LCS-1. Shown to preferably inhibit the growth of a variety of human lung adenocarinoma cell lines with EGFR and KRAS mutations (IC50=200nM). Prevents serum-induced activation of the ERK and PI 3-kinase/AKT signaling thereby affecting cell growth and survival. Apparent half-life of this compound is reported to be 6.6min in human liver microsomes. Group: Biochemicals. Grades: Highly Purified. CAS No. 41931-13-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Sodium Acetate-1,2-13C2 | Sodium Acetate-1,2-13C2 is an intermediate in synthesizing is an intermediate in synthesizing Diethylamine-13C4 Hydrochloride (D443486), a labelled salt of Diethylamine (D443485). Sodium Acetate-1,2-13C2 is also a labelled analogue of Sodium Acetate (S610970) is used in the textile industry to neutralize sulfuric acid waste streams, and as a photoresist while using aniline dyes. Sodium Acetate may be added to foods as a seasoning. Group: Biochemicals. Grades: Highly Purified. CAS No. 56374-56-2. Pack Sizes: 50mg, 250mg. Molecular Formula: 13C2H3NaO2, Molecular Weight: 84.02. US Biological Life Sciences. | Worldwide |
| Sodium Butyrate, 0.5M (Histone Deacetylase Inhibitor) | A short chain fatty acid shown to be an inhibitor of histone deacetylase (HDAC). Induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and inteferes with signal transduction processes, including the release of Ca2+ from intracellular stores. Downregulates the activity of serine/threonine protease kinase casein kinase II in HT29 cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 156-54-7. Pack Sizes: 10ml, 25ml, 50ml. Molecular Formula: C?H?NaO?, Molecular Weight: 110.09. US Biological Life Sciences. | Worldwide |
| Sodium Chlorate | Sodium Chlorate is used in the preparation of chlorine dioxide solution use in water treatment, as a food preservative agent, an antiseptic and also as a deodorant. Group: Biochemicals. Grades: Highly Purified. CAS No. 7775-9-9. Pack Sizes: 5g, 25g. Molecular Formula: ClNaO3. US Biological Life Sciences. | Worldwide |
| Sodium Cyanide | Sodium Cyanide is used in the synthesis of antihypertensive agents, such as 2-amino-4-aryl-2-imidazolines. Also used in the synthesis of nonpeptidic cyanamides as potent reversible inhibitors of human cathespins K and L. Group: Biochemicals. Grades: Highly Purified. CAS No. 143-33-9. Pack Sizes: 10g, 25g. Molecular Formula: CNNa. US Biological Life Sciences. | Worldwide |
| Sodium Hexafluoroaluminate | Cryolite is an insecticide and a pesticide. Group: Biochemicals. Grades: Highly Purified. CAS No. 15096-52-3. Pack Sizes: 2.5kg, 5kg. Molecular Formula: AlF6Na3, Molecular Weight: 209.94. US Biological Life Sciences. | Worldwide |
| Sodium L-(+)-Tartaric Acid Dihydrate | Sodium salt of L-(+)-Tartaric Acid (T007630), a naturally occurring chemical compound found in berries, grapes and various wines. It provides antioxidant properties and contributes to the sour taste within these products. Group: Biochemicals. Grades: Highly Purified. CAS No. 6106-24-7. Pack Sizes: 10g, 50g. Molecular Formula: C4H4Na2O6. US Biological Life Sciences. | Worldwide |
| Sodium Peroxide | Sodium Peroxide is a strong oxidizing agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 1313-60-6. Pack Sizes: 5g, 25g. Molecular Formula: Na2O2, Molecular Weight: 77.98. US Biological Life Sciences. | Worldwide |
| Sodium Selenite Pentahydrate | Sodium Selenite Pentahydrate, can be used in porcine serum in order to biofotify it with selenium to inhibit proliferation of three types of human cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 26970-82-1. Pack Sizes: 10g, 50g. Molecular Formula: H10Na2O8Se. US Biological Life Sciences. | Worldwide |
| Sorbitan | Sorbitan is a surfactants used for the preparation in α-Tocopherol-loaded niosome. A separation improvers for the separation of fatty acid methyl ester (FAME) mixtures. Group: Biochemicals. Grades: Highly Purified. CAS No. 1338-41-6. Pack Sizes: 5g, 25g. Molecular Formula: C18H36O2 C6H14O6, Molecular Weight: 284.4818217. US Biological Life Sciences. | Worldwide |
| SP-2509 | LSD1 is a promising target for cancer therapy. Epigenetic control of histone methylation isfrequently associated with oncogenesis and LSD1 is overexpressed in many types of cancer. siRNAknockdown of LSD1 has been shown to suppress growth of cancer cells. SP2509 is a selectiveand reversible LSD1 inhibitor with an IC50 of 10nM. SP2509 demonstrates a high specificity forLSD1, with no effect on MAOi. Group: Biochemicals. Grades: Highly Purified. CAS No. 1423715-09-6. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C19H20ClN3O5S. US Biological Life Sciences. | Worldwide |
| Spautin-1 (6-fluoro-N- [4-fluorobenzyl] quinazolin-4-amine, Specific and Potent AUtophagy Inhibitor 1, C43, Autophagy Inhibitor II) | A quinazolin compound that acts as a specific and potent inhibitor of autophagy and promotes Vps34 PI 3-kinase complex degradation by blocking the activity of USP 10 (IC50 = 580nM) and USP 13 (IC50 = 690nM) deubiquitinating enzymes. However, it does not affect the lipid kinase activity of Vps34. Also shown to reduce the level of cytoplasmic and nuclear p53. Sensitizes breast cancer cell lines (BCAP37, MCF-7, and BT549) to apoptosis under conditions of nutritional deprivation. Also shown to inhibit etoposide-induced cell death in Bax/Bak double knockout (DKO) cells. Normal cell lines (e.g., MDCK cells) do not undergo autophagy in the presence of Spautin-1. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SPDP Crosslinker | SPDP contains a dithiopyridyl group which is reactive towards cysteines (-SH groups) and an NHS group, which is useful when targeting primary amines (-NH2 groups). SPDP releases a byproduct, pyridine-2-thione after reacting with free sulfhydryl groups. By measuring the release of this byproduct at 343nm, the reaction can be easily followed. Contains a disulfide linkage in its spacer arm with a length of 6.8. Group: Biochemicals. Alternative Names: N-succinimidyl-3- (2-pyridyldithio) propionate; 3- (2-Pyridyldithio) propionic acid N-hydroxysuccinimide ester; 3- (2-Pyridyldithio) propionic acid NHS ester. Grades: Highly Purified. CAS No. 68181-17-9. Pack Sizes: 50mg, 250mg. US Biological Life Sciences. | Worldwide |
| (S)-Perharidine 1 | Potent and selective inhibitor of cyclin dependent kinases CDK1, CDK2, CDK5 and CDK9. Apoptosis inducer. Inhibits the proliferation of various cancer cell lines. Casein kinase 1 (CK1delta/epsilon) and DYRK1A inhibitor. Potential anti-inflammatory compound. Potential antidiabetic compound. Group: Biochemicals. Grades: Highly Purified. CAS No. 1133437-81-6. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Sphingosine Kinase 1 Inhibitor, SKI-178 (N'- (1E) -1- (3, 4-Dimethoxyphenyl) ethylidene) -3- (4-methoxyphenyl) -1H-pyrazole-5-carbohydrazide, Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide) | A cell-permeable pyrazolocarbohydrazide compound that acts as a potent, reversible, sphingosine competitive and ATP-non-competitive inhibitor of sphingosine kinase 1 (SphK1) activity with excellent selectivity over SphK2 (Ki = 1.33 and >> 25uM, respectively). Shown to suppress sphingosine-1-phosphate (S1P) production in A549 cells and efficiently induce apoptosis in several tumor cells (IC50 in the range of 0.1-1.8uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| Sphingosine Kinase Inhibitor IV, CB5468139 (N-(3-chloro-1,4-dioxo-1,4-dihydro-2-naphthalenyl)-N-cyclohexylacetamide, SK Inhibitor IV, Sphingosine Kinase Inhibitor IV) | A cell-permeable naphthoquinone derivative that acts as an ATP-competitive inhibitior against sphingosine kinase 1 (IC50 = 2uM; [sphingosine] = 10uM & [ATP] = 100uM) and several protein kinases, including, but not limited to, TNK2, AURKB, Met, Syk, AURKC, Fyn, Flt2, PIM2, MST2, CLK1, Tie1, and Fak (IC50 <2uM), while exhibiting much reduced potency toward DAG Kinase and sphingosine kinase 2 (37% and no inhibition, respectively, at 100uM). Shown to be more potent than SK1/2 dual inhibitor against kidney adenocarcinoma A498 proliferation (GI50 = 10 and 20uM, respectively; 48h) and the two inhibitors are also reported to induce differential modulations of A498 cellular ceramides and S1P levels when applied at their respective GI50. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Spinosad (A&D) | Spinosad is a broad spectrum insecticide and used as a reference standard. This compound is a mixture of Spinosyn A and Spinosyn D. Group: Biochemicals. Alternative Names: (5aR, 5bS, 14R, 16bR)-13-{[5-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl]oxy}-9-ethyl-14-methyl-7, 15-dioxo-2, 3, 3a, 5a, 5b, 6, 7, 9, 10, 11, 12, 13, 14, 15, 16a, 16b-hexadecahydro-1H-as-indaceno[3, 2-d]oxacyclododecin-2-yl 6-deoxy-2,3,4-tri-O-methylhexopyranoside; Blackhawk; Comfortis; Conserve; Entrust; Entrust WP; Extinosad; GF 120; GF 120 Fruit Fly Bait; GF 120 NF Naturalyte; GF 120 Naturalyte Fruit Fly Bait; GF 1587; Gardens Alive Bulls-Eye; LY 232105; Laser; Laser (insecticide); Naturalure; Naturalure Fruit Fly Bait; Naturalyte; PP 105; SpinTor; Spinoace; Spinosad 45% SC; Spinosad 45SC; Spinosad NT; Spinosyn A-spinosyn D mixt.; Success; Success 4; Success Naturalyte; Tracer; Tracer Naturalyte; Tracer Naturalyte Insect Control; XDE 105. Grades: Highly Purified. CAS No. 168316-95-8. Pack Sizes: 5mg, 10mg, 25mg, 50mg. US Biological Life Sciences. | Worldwide |
| sPLA2-IIA Inhibitor II, KH064 ( (S) -5- (4- (benzyloxy) phenyl) -4- (7-phenylheptanamido) pentanoic Acid, Phospholipase A2 Group IIA Inhibitor II, PLA2g2a Inhibitor II) | A reversible, potent, and selective sPLA2-IIA/PLA2g2a (phospholipase A2 group IIA) inhibitor (IC50 = 29nM) that displays much reduced potency against sPLA2-V/PLA2g5 (PLA2 group V; IC50 = 2uM) and is reported not to affect the activity of cytosolic cPLA2, Ca2+-independent iPLA2, 30 human GPCRs, and 25 other enzymes. In addition to being useful in studying PLA2g2a-mediated cellular responses in cultures in vitro (100% inhibition of LPS-induced PGE2 production in HMC-1 cells; 15 min 10uM pretreatment), KH064 is orally available in rats and efficacious in various rat disease models in vivo (5mg/kg p.o.), including adjuvant-induced arthritis, spontaneous hypertension, high fat diet-induced metabolic disorders. Comparing to the substrate-competitive inhibitor c(2NapA)LS(2NapA)R, KH064 also effectively chelates sPLA2-IIA active site Ca2+ in addition to targeting the enzyme's N-terminal lipid substrate binding site. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SR95531 (Gabazine, GABAA Receptor Antagonist, SR-95531, Gabazine, SR95531, SR 95531) | A selective, competitive antagonist of GABAA receptor (IC50 = 440nM) that does not affect pentobarbitone or etomidate- induced currents even at high concentrations (~100uM). Also shown to block glycine receptors, but with low affinity (Kb = 190uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 104104-50-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| (S)-(-)-Raclopride (Dopamine Receptor D2 Antagonist, (S)-Raclopride, Raclopride) | D2-like dopamine receptor antagonist targeting D2R (pKi =8.0), D3R (pKi = 7.9), and 5-HT1A R (pKi=5.2). Used to explore D2 like receptor mediated effects in neuropathic pain, and in antagonism studies of DA receptors during heroin usage and cocaine. D2 Receptor selectivity in various preps shows IC50 values around 32nM. Group: Biochemicals. Grades: Highly Purified. CAS No. 84225-95-6. Pack Sizes: 10mg. Molecular Formula: C??H??Cl?N?O?. US Biological Life Sciences. | Worldwide |
| SRPK Inhibitor, SRPIN340 (N- (2-Piperidin-1-yl-5- (trifluoromethyl) phenyl) isonicotinamide, Serine-Arginine-Rich Protein Kinase Inhibitor, SR Protein Kinase Inhibitor, SR Protein Phosphorylation Inhibitor 340, (SRPIN)340) | A cell-permeable isonicotinamide that acts as an ATP-competitive SRPK1-selective inhibitor (IC50 = 0.14 and 1.8uM, respectively, against mSRPK1 and mSRPK2) with much reduced activity against 143 other kinases. Shown to effectively counteract IGF-1-induced anti-angiogenic to pro-angiogenic VEGF isoforms switch both in cultures in vitro (1h 10uM SRPIN340 prior to 12h IGF-1 stimulation of PCIPs) and in a murine hypoxia-induced retinal neovascularization model in vivo (10pmol/uL/eye intraocular SRPIN340 injection) by inhibiting PKC/SRPK signaling-dependent, alternate splicing factor ASF- (SF2; splicing factor 2) mediated VEGF pro-mRNA PSS (proximal splice site) selection. Suppresses RNA virus Sindbis propagation (IC50 = 60uM in Vero cultures) and HCV-JFH1 replication (1 & 10uM SRPIN340 in Huh7.5.1 cultures). Exhibits no toxicity toward rats (2g/kg p.o. for 2 wks), CHO (5mg/ml for 24h), or Huh7 (30uM for 48h). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| (S)-Sulpiride ((S)-(-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide, D2-like Dopamine Antagonist, (s)-Sulpiride, Sulpiride) | Dopamine D2 receptor antagonist with good aqueous solubility. S-sulpiride (200nM) was used to confirm that dopamine currents were mediated through the D2 receptor in whole animal rat brain preps. IC50 of 0.01012uM Antagonist activity at human dopamine D2 receptor expressed in CHOp cells assessed as inhibition of quinopirole-induced mitogenisis. Group: Biochemicals. Grades: Highly Purified. CAS No. 23672-07-3. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| STAT3 Inhibitor XIII, C188-9 (N- (1, 2-Dihydroxy-1, 2-binaphthalen-4-yl) -4-methoxy Benzene sulfonamide, F1113-0789) | A cell-permeable binaphthol-sulfonamide compound that competitively disrupts Stat3 SH2 domain-pY peptide interaction and acts as a reversible inhibitor of Stat3 activation and Stat3-dependent gene transcription. Shown to block G-CSF stimulated pStat3 (IC50=4.1, 4.5 and 8.3uM in KG-1, Kasumi-1 and NB-4 cells, respectively), with no effect on ligand-induced pStat1 and selectively induce apoptosis of Stat3-dependent AML cells ((EC50 of 6-8uM) and growth arrest. Moderately affects Tie2 kinase activity (<50%) with minimal effect on JAK1, JAK2, Src family kinases and pERK1/2 and pAKT at 10uM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| STAT3 Inhibitor XI, STX-0119 (N-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-2-phenylquinoline-4-carboxamide) | A cell-permeable oxadiazolyl-quinolinecarboxamide that is shown to selectively suppress STAT3, but not STAT1, STAT5a, or STAT5b, DNA binding activity and prevent IL-6-stimulated STAT3 dimerization in HEK293 cells (by 99% at 100uM), as well as inhibit the expression of STAT3 target genes both in cultures in vitro (effective conc. 50uM) and in SCC3-derived tumors in mice in vivo (160mg/kg/day; p.o.). Group: Biochemicals. Grades: Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| STAT3 Inhibitor XVI (IL-6 Inhibitor) | A cell-permeable, arylsulphonamidyl thiophene amide that is shown to reduce IL-6-induced STAT3 transcriptional activity (EC50=15uM) in a luciferase reporter assay, in HeLa cells. It selectively inhibits STAT3, but not STAT1, phosphorylation following IL-6 stimulation in both HeLa and MDA-MB-231 breast cancer cells at concentrations of 10-30uM and 30-100uM, respectively. Following IL-6 stimulation, it suppresses the cell viability of STAT3-dependent cancer cells by 40% compared with that of STAT3-null cancer cells at the low micromolar level. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Stearoyl-CoA Desaturase 1 Inhibitor, MF-438 (2-methyl-5- (6- (4- (2- (trifluoromethyl) phenoxy) piperidin-1-yl) pyridazin-3-yl) -1, 3, 4-thiadiazole) | A cell-permeable, thiadiazole-pyridazine compound that acts as an inhibitor of Stearoyl-CoA Desaturase 1 (SCD1) with an IC50 of 2.3nM. In vivo, it exhibits an ED50 of 1-3mg/kg, p.o., in mouse liver PD assays. Group: Biochemicals. Grades: Highly Purified. CAS No. 921605-87-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Sterigmatocystin (NSC 201423, NSC 204985) | Intermediate of the biosynthetic pathway to aflatoxin B1. Mycotoxin. DNA synthesis inhibitor. Anticancer compound. Cytotoxic, carcinogenic and mutagenic. Acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitor. Shown to induce apoptosis in human peripheral lymphocytes and necrosis in rat liver. Induces sister chromatid exchanges in murine bone marrow cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 10048-13-2. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Stevioside-d2 (90%) | Isotope labelled Stevioside (S686730) is a glycoside from the stevia plant. Stevioside is a natural sweetening agent with sweetness about 250 times that of sugar with negligible effect on blood glucose. Stevioside, much like other steviol glycoside is known for its application in treatment of many diseases like diabetes and high blood pressure. It is also used as a food additive and in dietary supplements. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C3713CH58D2O18, Molecular Weight: 807.88. US Biological Life Sciences. | Worldwide |
| Streptochlorin (SF 2583A, 12815A, 4-Chloro-5-(3-indolyl)oxazole, 3-(4-Chloro-5-oxazolyl)-1H-indole) | Antibiotic. TNF-alpha-induced NF-kappaB activation inhibitor. Antiangiogenic. Apoptosis inducer. Anticancer compound. Selective cytotoxic against several cancer cell lines. Tyrosinase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 120191-51-7. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
| Strobilurin B ((2E,3Z,5E)-Methyl-6-(4-chloro-3-methoxyphenyl)-2-(methoxy-methylene)-3-methylhexa-3,5-dienoate) | Antifungal. Respiration inhibitor. Blocks the electron transfer between cytochrome b and cytochrome c1. Group: Biochemicals. Grades: Highly Purified. CAS No. 65105-52-4. Pack Sizes: 500ug, 1mg. US Biological Life Sciences. | Worldwide |
| Sulfinpyrazone | Sulfinpyrazone is used in the treatment of gout acting as a uricosuric medication. Group: Biochemicals. Grades: Highly Purified. CAS No. 57-96-5. Pack Sizes: 2.5g, 10g. Molecular Formula: C23H20N2O3S. US Biological Life Sciences. | Worldwide |
| Sulfosuccinimidyl Stearate Sodium | Sulfosuccinimidyl Stearate Sodium is an analog of Sulfosuccinimidyl Oleate Sodium (S689200). Group: Biochemicals. Grades: Highly Purified. CAS No. 163451-87-4. Pack Sizes: 25mg, 250mg. Molecular Formula: C22H38NNaO7S, Molecular Weight: 483.59. US Biological Life Sciences. | Worldwide |
| Sulfur-(32-S) | Sulfur-(32-S). Group: Biochemicals. Grades: Highly Purified. CAS No. 13981-57-2. Pack Sizes: 100mg, 250mg. Molecular Formula: H232S, Molecular Weight: 33.99. US Biological Life Sciences. | Worldwide |
| Surfactin | Surfactin is a lipopeptide antibiotic and biosurfactant. Group: Biochemicals. Grades: Highly Purified. CAS No. 24730-31-2. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C53H93N7O13. US Biological Life Sciences. | Worldwide |
| Survivin Antagonist, S12 (Survivin Inhibitor II, 3-(2-(benzo[d][1,3]dioxol-5-yl)-2-oxoethyl)-5-bromo-3-hydroxyindolin-2-one) | A cell-permeable hydroxyindolinone compound that acts as a selective antagonist of survivin. Induces mitotic arrest and blocks cell cycle at G2/M phase (~40uM in HeLA cells) leading to apoptotic cell death. Shown to bind to a specific cavity adjacent to the interface involved in the dimerization of survivin. Binding is specific only to native survivin and does not affect any mutant forms. Inhibits HCT116 cell proliferation independently of their p53 status and reduces tumor volume in xenograft models in a dose-dependent manner (5-15mg/kg). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Survivin Inhibitor III, LLP-3 (Survivin-Ran Interaction Blocker, LLP3, 4-(3,5-bis(Benzyloxy)phenyl)-6-(5-chloro-2-hydroxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile) | A cell-permeable, dihydropyridinone compound that selectively disrupts survivin-Ran interaction in cell-free binding assays (IC50 <0.3uM) and in U87 glioma cells (by 55% in 24h; 20uM) via direct binding at survivin protein-protein interaction interface, while exhibiting much reduced or little potency against survivin-Smac/DIABLO, survivin-survivin, or XIAP-Smac/DIABLO interaction. LLP-3 treatment abrogates neurosphere formation in GMB cultures (IC50 ≤35uM) by selectively depleting CD133+ GSC population via apoptosis induction. TMZ, in comparison, enriches GMB GSC population by preferentially eradicating non-GSC population. LLP-3 is also efficacious in treating human GMB xenograft in mice in vivo (25mg/kg/day via i.p.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
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