USBiological 4 - Products
Worldwide
Our biochemicals, antibodies, recombinant proteins, cell culture media and molecular biology kits are used in virtually all scientific applications.From affordable research quantities to larger bulk amounts.
| Product | Description | |
|---|---|---|
| PIP3 Antagonist, PITenin-7 | A cell-permeable benzoylthiourea compound that acts as a PIP3 (phosphatidylinositol-3, 4, 5-triphosphate) mimic and inhibits PI 3-K/PIP3/Akt signaling. Shown to efficiently disrupt PIP3/Akt1 PH (pleckstrin-homology) domain interaction over PIP3/PDK1 PH (IC50=13.4 and 52.3uM) in a reversible manner, and remain inactive toward PIP3/Btk, PIP3/ARNO, PIP3/GRP1 and PIP2/PLC-d/TAPP1/TAPP2 PH domains. Blocks phosphorylation of Akt-Ser473 and -Thr308 and its downstream targets, GSK-3B-Ser9 and S6-Ser235/236 and induces metabolic stress and cell death (IC50=6.6uM) in PTEN-deficient U87MG cells. Further, synergizes with Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 and Akt Inhibitor X. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Piperlongumine (Piplartine, (E) -1- (3- (3, 4, 5-Trimethoxyphenyl) acryloyl) -5, 6-dihydropyridin-2 (1H) -one) | A cell-permeable, orally bioavailable natural product isolated from the plant species, Piper longum L, which selectively induces cell death in cancer cells that express both wild-type and mutant p53, dose-dependently from 1-15uM, but not in primary normal cells and non-transformed immortalized cells. It significantly enhances wild-type p53 and PUMA expression, and inhibits the expression of several pro-survival proteins, including BCL2, surviving, and XIAP, in various types of cancer cells, but not in normal cells. It elicits ROS and apoptosis in several human cancer cells (EJ, MDA-MB-231, U2OS and MDA-MB-435), possibly through interaction with oxidative stress responders such as GSTP1 and CBR1, and can be reversed by NAC (3mM) in EJ cells. Additionally, it exhibits anti-tumor effects and inhibits the formation of blood vessels in xenograft-tumor mice without obvious toxicity, and inhibits tumor growth and their associated metastases in a MMTV-PyVT breast cancer transgenic mouse model Group: Biochemicals. Grades: Highly Purified. CAS No. 20069-09-4. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Pirenzepine Dihydrochloride | An antagonist selective for mAChR subtype M1. Used for studying the functional roles of M1 receptors in both central and peripheral nervous systems. Group: Biochemicals. Grades: Highly Purified. CAS No. 28797-61-7. Pack Sizes: 100mg. Molecular Formula: C??H??N?O? 2HCl. US Biological Life Sciences. | Worldwide |
| Pirimiphos-methyl-d6 | Pirimiphos-methyl-d6 is an isotope labelled analog of Pirimiphos-methyl. Pirimiphos-methyl is a phosphorothioate used as an insecticide. Pirimiphos-methyl is commonly used for mosquito control as well as control of greenhouse crop pests and stored-product insects. Group: Biochemicals. Grades: Highly Purified. CAS No. 1793055-06-7. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C11H14D6N3O3PS, Molecular Weight: 311.37. US Biological Life Sciences. | Worldwide |
| PJ-34 Hydrochloride | A potent, water-soluble poly(ADP-ribose) polymerase (PARP) inhibitor (EC50 = 20nM). Inhibits peroxynitrite-induced cell necrosis and displays significant, dose-dependent anti-inflammatory effects in a variety of local inflammation models. Provides cardioprotection by decreasing myocardial infarct size. Suppresses cell growth in liver cancer cells. Group: Biochemicals. Alternative Names: N-(6-Oxo-5,6-dihydro-phenanthridin-2-yl)-N,N-dimethylacetamide Hydrochloride. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| PK11195 | An isoquinoline carboxamide that acts as a potent ligand for peripheral bezodiazepine receptor (Kd = 20nM). Exhibits anti-inflammatory properties. Binds to monocytes and following lesioning its binding up-regulated in brain macrophages and activated microglia. Shown to enhance the susceptibility of cells to apoptosis induction by DNA damaging agents and can reverse the suppression of apoptosis by Bcl-2. Serves as a ligand of the outer membrane translocator protein and reduces mitochondrial transmembrane potential within 30 minutes of exposure (100uM).CAS Number:85532-75-8. Group: Biochemicals. Grades: Highly Purified. CAS No. 85532-75-8. Pack Sizes: 10mg. Molecular Formula: C??H??ClN?O. US Biological Life Sciences. | Worldwide |
| PK 11195 | Cell-permeable. A Selective peripheral benzodiazepine antagonist. Enhances apoptosis and induces mitochondria cytochrome c release. Inhibits insulin secretion induced by glucose. Also displays anticancer activity. Group: Biochemicals. Alternative Names: 1- (2-Chloro phenyl ) -N- methyl -N- (1- methyl propyl ) -3-isoquinolinecarboxamid e . Grades: Highly Purified. CAS No. 85532-75-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| PKA Inhibitor 14-22 Amide, Cell-Permeable, Myristoylated | Heat-stable protein kinase inhibitor (PKI) peptide sequence (14-22) that has been myristoylated at the N-terminus, enhancing its cell-permeability. The non-myristoylated version of this peptide is a highly specific inhibitor (Ki=6nM) of cAMP-dependent protein kinase. Group: Biochemicals. Alternative Names: Myr-N-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH?. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| PKC Activator VII, CGK062 (Protein Kinase C Activator VII) | A cell permeable coumarin-containing compound that is shown to activate PKCalpha activity and induce cellular PKCalpha membrane translocation (Effective conc. 12.5 to 50uM) as well as PKCalpha-mediated signaling events. Effectively affects the viability of CRT-dependent cancer cells (IC50 = 1.62 to 18.6uM; 48h) in vitro and suppresses PC3-derived tumor expansion in mice (50 & 100mg/kg/day; i.p) in vivo, while exhibiting little cytotoxicity toward WI38 normal fibroblasts. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C??H??O?, Primary Target IC50: 12.2uM. US Biological Life Sciences. | Worldwide |
| PKM2 Activator III (N- (4- (4- (2-Methoxyphenyl) piperazine-1-carbonyl) phenyl) quinoline-8-sulfonamide, Pyruvate Kinase M2 Activator III) | A cell-permeable quinoline-sulfonamide that acts as a potent allosteric PKM2 activator both in cell-free enzymatic assays (AC50 = 17nM with 40ng PKM2/200ul) and in cultures (AC50 = 45nM in A549 cells) via a high affinity, 2:1 stoichiometric binding, effectively locking PKM2 in an active tetrameric state resistant to known intracellular negative regulators of FBP-activated PKM2 tetramer. PKM2 stimulation by compound treatment is shown to result in decreased serine biosynthesis (by 56%; 500nM for 24h) with concomitant increase in serine influx as a compensating mechanism for maintaining cellular serine level necessary for supporting A549 proliferation. Simultaneous PKM2 activation and culture serine withdrawal results in cytostatic A549 growth arrest, but not apoptosis. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PKR Inhibitor III, 7DG (Double-stranded RNA-activated Protein Kinase Inhibitor III, EIF2AK2 Inhibitor III, 7-Desacetoxy-6,7-dehydrogedunin, Double-stranded RNA-dependent Protein Kinase Inhibitor III) | A cell-permeable gedunin analog that directly targets PKR via reversible interaction inhibits PKR-mediated cellular events by disrupting PKR signaling complexes assembly, such as IkK complex and inflammasome / pyroptosome, resulting in effective blockage of LPS-induced IkBbeta degradaion (20uM) and protection against anthrax toxin LT-induced caspase-1 activation as well as subsequent pyroptosis (10uM) in murine macrophage J774 cultures. PKR is also known to mediate LT-induced apoptosis via its kinase activity in LPS-primed Macrophages derived from C57BL/6 with a resistent NLRP1 allele, inhibitable by C16, but not by 7DG, while LT-induced pyroptosis in J774 cultures is insensitive to C16 treatment. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
| Plasma, Cynomolgus Monkey | ELISA Testing: Group: Biologicals. Grades: Plasma. Pack Sizes: 10ml. US Biological Life Sciences. | Worldwide |
| PLD Inhibitor, FIPI | A cell-permeable, PLD1/2 inhibitor (IC50=1nM and 10nM for PLD1 and PLD2, respectively, in a CHO cell based assay, and IC50=20nM for PLD2 in a biochemical assay), that displays no activity toward MitoPLD, and is selective for PLD1 and PLD2 over other PLD superfamily enzymes. It is also shown to block PLD2-dependent effects on cytoskeletal reorganization and cell trafficking in CHO cells, and diminish fMLP-directed neutrophil chemotaxis in HL60 cells at 750nM. Unlike 1-butanol, this compound does not affect glucose-stimulated insulin secretion in Min6 pancreatic b-cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??FN?O?, Molecular Weight: 421.2. US Biological Life Sciences. | Worldwide |
| PluriSln 1 (4-Pyridinecarboxylic acid 2-phenylhydrazide) | PluriSln 1 (4-Pyridinecarboxylic acid 2-phenylhydrazide). Group: Biochemicals. Grades: Highly Purified. CAS No. 91396-88-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| PLX4720 | Potent and selective cell permeable B-Raf (V600E) and c-Raf-1 (Y340D/Y341D) inhibitor. Antitumor compound. ERK phosphorylation is potently inhibited exclusive in B-Raf(V600E)-bearing tumor cell lines. Group: Biochemicals. Alternative Names: N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide, Raf Kinase Inhibitor V. Grades: Highly Purified. CAS No. 918505-84-7. Pack Sizes: 5mg, 25mg. Molecular Formula: C??H??ClF?N?O?S. US Biological Life Sciences. | Worldwide |
| PME-1 Inhibitor, AMZ-30 | A cell-permeable sulfonyl acrylonitrile compound that acts as a potent and irreversible inhibitor of protein phosphatase methylesterase-1 (PME-1; IC50=600nM and 2.5uM in human cell lysates and in HEK 293T cells, (respectively) with 100-fold greater selectivity over other serine hydrolases; does not function as a general thiol-reactive probe. Shown to lower demethylated PP2A levels by ~80% at 20uM with elevated methylated PP2A (protein phosphatase 2A) form in PME-1 overexpressing HEK 293T cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??FN?O?S?, Molecular Weight: 462.6. US Biological Life Sciences. | Worldwide |
| PNU-120596 (a7 nAChR Agonist, 1-(5-chloro-2,4-dimethoxy-phenyl)-3-(5-methyl-isoxazol-3-yl)-urea, α7 Neuronal Nicotinic Acetylcholine Receptor Agonist) | A urea derivative that acts as a potent, selective, and reversible positive allosteric modulator for the a7 subtype of neural nicotinic acetylcholine receptors (EC50 = 216nM), with no significant effect on a4B2, a3B4 and a9a10 receptors. Specifically increase a-7 nAChR-mediated channel currents and channel mean open time in cultured neurons (~1mM). However, it does neither affect ion selectivity nor unitary conductance. Shown to cross the blood-brain barrier. Causes conformational changes in the ligand binding domain of a7 nicotinic receptors that partially overlap with those caused by acetylcholine. Causes changes in cysteine accessibility at the inner beta sheet, transition zone, and agonist binding site. Also reported to potentiate agonist-evoked GABAergic postsynaptic inward currents in somatodendritic membrane of hippocampal interneurons. Group: Biochemicals. Grades: Highly Purified. CAS No. 501925-31-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PNU 282987 (PNU-282987, N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide Hydrochloride, alpha7 nAChR Agonist, PNU 282987, alpha 7 Nicotinic Acetylcholine Receptor Agonist, PNU 282987, PNU282987) | A potent agonist highly selective for alpha7 nAChRs (Ki = 26nM). Used in investigating the roles of alpha7 nAChRs in sensory gating, learning and memory, cognitive functions, and treatment of Schizophrenia. Group: Biochemicals. Grades: Highly Purified. CAS No. 123464-89-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Polo-like Kinase Inhibitor V, Poloxin (2-isopropyl-5-methyl-4- (2-methylbenzoyloxyimino) cyclohexa-2, 5-dienone) | A thymoquinone derivative, non-ATP competitive Polo-like Kinase 1 (Plk1) inhibitor specifically targeting the polo-box domain (PBD) of Plk1 (IC50)=4.8uM. Reduces both chromosome and kinetochoral localization of Plk1, induces chromosome congression defects , mitotic arrest in prometaphase, and apoptosis in HeLa cells at 25uM. Exhibits anti-proliferative effects in a range of cancer cell lines, and in a mouse Xenograft model involving HeLa and MDA-MB-231 cells at 40mg/kg. Group: Biochemicals. Grades: Highly Purified. CAS No. 321688-88-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Polyethylene Glycol 600 (PEG 600) | Poly(ethylene Glycol) molecules of an average molecular mass of 600. Poly(ethylene Glycol) is used in various applications from industrial chemistry to biological chemistry. Recent research has shown PEG maintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals. In rats, it has been shown to aid in the repair of severed sciatic axons, helping with nerve damage recovery. It is industrially produced as a lubricating substance for various surfaces to reduce friction. PEG is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods. Group: Biochemicals. Alternative Names: Polyglycol; Polyethylene oxide; Polyoxyethylene. Grades: Highly Purified. CAS No. 25322-68-3. Pack Sizes: 5g, 25g. Molecular Formula: (C?H?O)nH?O, Molecular Weight: 600. US Biological Life Sciences. | Worldwide |
| Polyketomycin (Antibiotic K99-5147) | Tetracyclic quinone glycoside. Antibacterial and antimalarial. Antitumor compound. Group: Biochemicals. Grades: Highly Purified. CAS No. 200625-47-4. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Polyquaternium 11 (20% in H2O) | Polyquaternium 11 is found to suppress melanin elution in shampoo thus may prevent hair from dulling after repeated shampoo use. Group: Biochemicals. Grades: Highly Purified. CAS No. 53633-54-8. Pack Sizes: 1g, 5g, 10g. Molecular Formula: C18H35N2O3+ C2H5O4S- (C2H4)x (C3H6)y. US Biological Life Sciences. | Worldwide |
| Polyquaternium 39 | Polyquaternium-39 is used in a emulsifier-free foundation with a positive zeta potential and is used in the flocculation treatment of oilfield sewage. Group: Biochemicals. Grades: Highly Purified. CAS No. 25136-75-8. Pack Sizes: 100mg, 500mg, 1g. Molecular Formula: (C14H25ClN2O3)x, Molecular Weight: 304.81. US Biological Life Sciences. | Worldwide |
| PON1 Activator (ZNPA, (Z)-2,3-bis (4-nitrophenyl)-acrylonitrile) | A cell-permeable stilbene derivative that serves as an aryl hydrocarbon receptor (AhR) and acts as a highly specific and potent inducer of paraoxonase 1 (PON1). Shown to be a better activator of PON1 mRNA (EC50=1uM) and inducer of PON1 enzymatic activity (>3-fold at 5um) when compared to resveratrol. However, it is devoid of any activity against estrogen receptors and is not shown to inhibit activity of tyrosine kinases. Also shown to antagonize the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cytochrome P4501A1 (CYP1A1). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Porcn Inhibitor II, C59 (Wnt-C59, Wnt Pathway Inhibitor XVI, 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide) | A cell-permeable pyridinylphenyl-acetamide that is much more potent than IWP-2 in inhibiting MBOAT family member Porcupine-mediated Wnt palmitoylation (IC50 = 74 pM in STF reporter assays using Wnt3a-transfected HEK293). Shown to be effective against Porcn of murine and human, but not xenopus, species and potently inhibit the processing of both canonical and non-canonical Wnt subtypes. C59 is demonstrated to be orally active and effectively suppress MMTV-WNT1 tumor expansion in mice (5mg/kg & 10mg/kg p.o.) in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 1243243-89-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Porcn Inhibitor III, IWP-L6 (IWPL6, Wnt Pathway Inhibitor XIX) | A cell-permeable pyridinyl-phenylacetamide that is reported to be 60-times more potent than IWP-2 in suppressing autonomous Wnt signaling in murine L-Wnt-STF fibroblasts (IC50 = 0.5nM) and 100-times more potent in blocking branching morphogenesis in cultured murine embryonic kidney (complete blockage at 50nM). Also shown to be at least twice as potent as TNKS inhibitor IWR-1 in preventing the regeneration of severed zebrafish tailfin and in inhibiting zebrafish embryo prosterior axis formation (Effective conc = 5uM). Its susceptibility to metabolization by serum carboxylesterase limits its in vivo use in rats and mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 1427782-89-6. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S?. US Biological Life Sciences. | Worldwide |
| Potassium Bromate | Potassium Bromate is used in the catalytic and non-catalytic roles of DNA polymerase K in protection of human precursor leukemia cells against genotoxic stresses. Also used in the study of related molecular mechanism of carcinogen participating in tumor metastasis. Group: Biochemicals. Grades: Highly Purified. CAS No. 7758-1-2. Pack Sizes: 5g, 100g. Molecular Formula: BrHO3; K. US Biological Life Sciences. | Worldwide |
| Potassium Nitrate | Potassium Nitrate is used in fertilizers as a source for nitrogen and potassium. It is also used widely in food preservation and also as a treatment for pulpitis. Group: Biochemicals. Grades: Highly Purified. CAS No. 7757-79-1. Pack Sizes: 5g, 25g. Molecular Formula: KNO3. US Biological Life Sciences. | Worldwide |
| Potassium Trifluoro(2,2,2-trifluoroethyl)borate | Potassium Trifluoro(2,2,2-trifluoroethyl)borate is used as a reactant in the preparation of functionalized borazaronaphthalenes from reaction with aminostyrenes. Also used in the preparation of azaborines via palladium-catalyzed Suzuki-Miyaura cross-coupling. Group: Biochemicals. Grades: Highly Purified. CAS No. 1510778-85-4. Pack Sizes: 50mg, 100mg. Molecular Formula: C2H2BF6K, Molecular Weight: 189.94. US Biological Life Sciences. | Worldwide |
| PP1 Analog IV, 3-IB-PP1 (3-Iodobenzyl PP1 Analog) | A cell-permeable enlarged PP1 analog that acts as a potent, ATP-competitive and reversible inhibitor of asAkt1/2/3 (IC50=28, 240 and 120nM, respectively) over wtAkt1/2/3 (IC50= >10uM). Shown to hyperphosphorylate Akt-Ser473 and -Thr308 in HEK293 cells coexpressed with myr-HA-asAkt1 or myr-HA-asAkt1/2/3 with no effect on pGSK-3bSer9 levels and wtAkt expressing cells. Also, specifically blocks the inhibitory function of membrane asCsk with diminished activity towards wtCsk, induces phosphorylation of Lck-Tyr394 and ERK1/2 in primary mouse T cells (EC50 ~0.5uM) and rapidly activates T cell receptor signaling. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C16H18IN5, Molecular Weight: 407.3. US Biological Life Sciences. | Worldwide |
| PP1 Analog V, 2,3-DMB-PP1 (4-Amino-1-tert-butyl-3- (2, 3-dimethylbenzyl) pyrazolo[3, 4-d]pyrimidine, 1-tert-Butyl-3-(2,3-dimethylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Syk ASKA Inhibitor II, PDK1 ASKA Inhibitor) | A cell-permeable 3-MB-PP1 analog that is more effective than 3-MB-PP1 in inhibiting SykM442A S505A ASKA- (analog-sensitive kinase alleles) mediated cellular calcium flux (98% vs. 20% inhibition, respectively, by 1uM 2,3-DMB-PP1 or 3-MB-PP1) in Syk MASA-expressing DT40 cells. Also shown to selectively inhibit L159G ASKA, but not wt, PDK1-dependent GSK3&alpha Ser21 and S6 Ser235/236 phosphorylation upon IGF1 stimulation in mES cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 956026-24-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PP2A Activating Ligand, ITH12246 | A cell-permeable, relatively non-toxic, 1,8-naphthyridine derived compound that blocks the inhibitory effect of protein phosphatase inhibitors, such as okadaic acid, on protein phosphatase 2A (PP2A). Exhibits blood-brain barrier permeability. Protects neurons against beta-amyloid peptides (Ab1-42) toxicity and okadaic acid-induced tau hyperphosphorylation. Also protects against rotenone and oligomycin A induced neurotoxicity in SH-SY5Y neuroblastoma cells (at ~300nM). Prevents the development of glutamate-induced neuronal lesions in rat hippocampal slices by up-regulating PP2A (~3uM). Shown to reverse the scopolamine-induced memory loss in mice (~10mg/kg i.p) and significantly reduces the infarct volume in an animal model of stroke (~2.5mg/kg). Also acts as an inhibitor of acetylcholinesterase activity in Electrophorus electricus (IC50 = 60nM) and human erythrocytes (IC50 = 780nM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?·HCl. US Biological Life Sciences. | Worldwide |
| PPAR Agonist IX, GQ-16 ((Z)-5-(5-Bromo-2-methoxybenzylidene)-3-(4-methyl-benzyl)-thiazolidine-2,4-dione) | A cell-permeable thiazolidinedione that acts as a PPARg-selective agonist (Ki=160nM) and blocks Cdk-5-mediated Ser273 phosphorylation by stabilizing PPARg b-sheet structure, exhibiting no detectable activity towards PPARa, PPARd, or RXRa. Although a weaker PPAPg agonist than Thiazolidinediones (TZDs) family rosiglitazone (Max. fold of transactivation induction =8.57 and 24.8 with 10uM respective compound in U-937 reporter assays), GQ-16 can be safely administered at a higher dosage (20mg/kg/day; oral gavage) in mice to achieve similar in vivo efficacy as rosiglitazone (4mg/kg/day; o.g.) without adverse side effects commonly seen with TZDs. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| PPAR-beta/delta Antagonist II, GSK3787 (4-Chloro-N-(2-((5-trifluoromethyl)-2-pyridyl) sulfonyl) ethyl) benzamide, PPARb Antagonist I, PPARd Antagonist I) | A cell-permeable pyridylsulfone that acts as a selective, high affinity PPARb (PPARd) ligand (IC50 in PPAR ligand displacement assays=200nM against human PPARb and >10uM against PPARa or PPARg) and effectively antagonizes agonist-induced, but not basal, PPARb transcription activity both in cultures in vitro (IC50=126nM in CV-1 cells) and in mice in vivo (82% and 71% inhibition of 10mg/kg GW0742-induced Adr and Angptl4 mRNA upregulation, respectively, in colon epithelium; 10mg/kg GSK3787; p.o.) by covalently modifying PPARb at Cys249. GSK3787 is also shown to exhibit weak agonistic activity toward PPARg (1.2-fold increase above basal level by 1uM GSK3787), and effectively block the more potent agonist GW1929 from further stimulation (1.5 and 3.5-fold above basal by 0.3uM GW1929 in the presence or absence of 1uM GSK3787, respectively). Group: Biochemicals. Grades: Highly Purified. CAS No. 188591-46-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PPARbeta/delta Antagonist, PT-S58 (PPARb Antagonist II, Methyl 3- (N- (4- (tert-butylamino) -2-methoxyphenyl) sulfamoyl) thiophene-2-carboxylate, PPARd Antagonist II) | A cell-permeable, diaryl sulfonamide PPARb/d subtype-specific pure competitive antagonist with an IC50 of 98nM. Antagonizes ligand binding without enabling coregulator interactions. Inhibits the PPARb/d specific agonist-induced transcriptional activity in cell cultures. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PPAR-beta/delta Inverse Agonist (Methyl 3- (N- (4- (hexylamino) -2-methoxyphenyl) sulfamoyl) thiophene-2-carboxylate, ST247) | A cell-permeable, diaryl sulfonamide inverse agonist that demonstrates selectivity for the ligand-binding domain of the PPAR beta/delta receptor (IC50=93nM). Enhances the interaction of the PPARb/d ligand-binding domain with the co-repressor, SMRT-ID2 (EC50=10nM). Down-regulates the peroxisome proliferator response elements (PPREs)-driven target gene, ANGPTL4. Inhibits PPARb/d- specific agonist-induced transcriptional activity in human myofibroblasts and mouse thioglycollate-elicited peritoneal macrophages. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PPAR gamma Modulator, SR1664 ( (S) -4'- ( (2, 3-dimethyl-5- (1- (4-nitrophenyl) ethylcarbamoyl) -1H-indol-1-yl) methyl) biphenyl-2-carboxylic Acid) | A cell-permeable non-thiazolidinediones derivative that binds tightly to peroxisome proliferator-activated gamma (PPAR-g) receptor (Ki=29nM; IC50=80nM), but does not exhibit any transcriptional agonism. Unlike TZD compounds, it does not induce weight gain or diminish hematocrit. Shown to effectively block CDK-5-mediated phosphorylation of Ser273 of PPAR-gamma in adipose tissue. Supresses hepatic glucose production, reduces plasma free fatty acid levels, and improves insulin sensitivity of adipose tissue. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C??H??N?O?, Molecular Weight: 547.6. US Biological Life Sciences. | Worldwide |
| Pramipexole Dihydrochloride (Pramipexole, Dopamine D2-like Receptor Agonist, Pramipexole, Dopamine D3 Receptor Agonist, Pramipexole, (S) -N-propyl -4, 5, 6, 7-tetra hydrobenzothiazole-2, 6-diamine Dihydrochloride) | Non-ergot Dopamine receptor agonist with selectivity for the D3 receptor (Ki values are 0.5, 3.3, 3.9 and 3.9nM for D3, D2S, D2L and D4 receptors respectively). Exhibits very low affinity for serotoninergic 5-HT2A and 5-HT2B receptors, as well as D1-type receptors. Shows good solubility in aqueous media (100mM water and 100mM DMSO). Immediate-release (IR) pramipexole dihydrochloride is indicated for the treatment of signs and symptoms of idiopathic Parkinsons disease (PD). It is administered alone (without levodopa) or in combination with levodopa, during the entire progress of the disease, up to an advanced stage. Currently, it is also indicated for the treatment of moderate-to-severe primary restless legs syndrome (RLS). Group: Biochemicals. Grades: Highly Purified. CAS No. 104632-25-9. Pack Sizes: 10mg. Molecular Formula: C??H??N?S 2HCl. US Biological Life Sciences. | Worldwide |
| Prazosin Hydrochloride | Prazosin Hydrochloride (Terazosin EP Impurity K) is an antihypertensive. α1-Adrenergic blocker. Prazosin hydrochloride, a quinazole derivative, is a very potent and highly selective antagonist for apha-1-adrenoceptors (affinity for alpha-1 is about 1000-fold greater than for alpha-2 receptors). Mainly used as a clinic vasodilator for blood pressure control without increasing the heart rate or significantly impairing sympathetic functions. Has also been used clinically to treat anxiety, PTSD, and panic disorder. An excellent candidate for research studying brain functions mediated through alpha-1-adrenergic receptors, such as reward, pleasure, aggression, fear, anxiety, and addiction. Group: Biochemicals. Alternative Names: [4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-furanylmethanone Hydrochloride; 1- (4-Amino-6, 7-dimethoxy-2-quinazolinyl) -4- (2-furanylcarbonxyl) piperazine Hydrochloride; Adversuten; Adverszuten; Alpress LP; Furazosin; Lentopres; NSC 292810; Peripress; Terazosin EP Impurity K. Grades: Highly Purified. CAS No. 19237-84-4. Pack Sizes: 100mg, 250mg, 500mg. Molecular Formula: C??H??ClN?O?, Molecular Weight: 419.86r. US Biological Life Sciences. | Worldwide |
| Pre-mRNA Splicing Inhibitor, Isoginkgetin | A cell-permeable, naturally isolated Ginkgo biloba biflavanoid that acts as a general pre-mRNA splicing inhibitor (ICmax=50uM in splicing assays using HeLa nuclear extract) by blocking the spliceosome-meidated splicing process at the prespliceosome/A complex stage. Isoginkgetin treatment is shown to result in growth arrest in HEK293-derived cultures in a reversible manner without affecting cell viability (33uM for 24h).217696 is a cell-permeable inhibitor of pre-mRNA splicing. Blocks spliceosome-mediated splicing process at the pre-spliceosome/A complex stage. Group: Biochemicals. Alternative Names: 8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one. Grades: Highly Purified. CAS No. 548-19-6. Pack Sizes: 10mg. Molecular Formula: C??H??O??, Molecular Weight: 566.5. US Biological Life Sciences. | Worldwide |
| PRMT Inhibitor VI (1- (Benzo[d][1, 2, 3]thiadiazol-6-yl) -3- (2-cyclohexenylethyl) urea, 1-(1,2,3-Benzothiadiazol-6-yl)-3-[2-(1-cyclohexen-1-yl)ethyl]urea, Protein Arginine Methyltransferase Inhibitor VI) | A benzothiadiazolyl-cyclohexenylethylurea compound that binds to protein arginine methyltransferase 3 at the dimer interface and selectively inhibits PRMT3 activity in an allosteric manner (IC50 = 1.6uM), while being non-competitive with respect to AdoMet (S-adenosyl-L-methionine; SAM) or peptide substrates (Ki = 2.9 and 4.2 mM, respectively). Exhibits little or no inhibitory activity against PRMT1/4/5/8 or protein lysine methyltransferases, EHMT1, SUV39H2, SETD7, and SETD8, even at concentrations above 100uM. Although cell-permeable, it is metabolically unstable and therefore not recommended for cell cultures or in vivo applications. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?OS, Primary Target: PRMT3. US Biological Life Sciences. | Worldwide |
| Prochloraz-d7 | Prochloraz-d7 is the labeled version of Prochloraz (P755280), which is used as a fungicide. Prochloraz (P755280) showed efficacy against cereal powdery mildew. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C15H9D7Cl3N3O2, Molecular Weight: 383.71. US Biological Life Sciences. | Worldwide |
| Prodigiosin, Serratia marcescens (NSC 47147, Casein Kinase I Inhibitor IV, 2-Methyl-3-pentyl-6-methoxyprodigiosene) | A cell-permeable tripyrrole alkaloid compound that displays immunosuppressive and anti-tumor properties irrespective of p53 status and multidrug resistance. Shown to selectively upregulate p21WAF/CIP1 and NAG-1 (nonsteroidal anti-inflammatory drug-activated gene 1) and downregulate survivin expression levels, induce mitochondria-mediated apoptosis and cell cycle arrest in tumor cells. Prevents FADD phosphorylation (IC50=2.0uM in A549-FKR cells) through inhibition of FADD-kinase CK1a (IC50 ~6.0uM in SW620-BGCR cells) and augments cisplatin -induced apoptosis. Blocks NF-kB activation by decreasing plkBa (by 63% at 3uM) and lkBa levels in A549 cells, and shrinks tumor growth in A549-FKR tumor xenograft mouse model (3mg/kg, i.p., o.d.). Group: Biochemicals. Grades: Highly Purified. CAS No. 82-89-3. Pack Sizes: 200ug. US Biological Life Sciences. | Worldwide |
| Prolyl Endopeptidase Inhibitor III, KYP-2047 ((S)-1-((S)-1-(4-phenylbutanoyl)-pyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile, 4-phenylbutanoyl-Lprolyl-2(S)-cyanopyrrolidine, PREP Inhibitor III, KYP-2047) | A cell-permeable, potent, fast-acting, and selective inhibitor of prolyl oligopeptidase (PREP) (Ki = 23 pM). Reported to cross the blood-brain barrier. Inhibits about 85% PREP activity within 10 minutes of administration and exhibits a half-life of about 4.8h. Exhibits higher lipophilicity that increases its penetration across biological membranes in vivo. Maximum plasma and brain levels are achieved within 10 minutes following its i.p. administration. Shown to block oxidative-stress induced alpha-synuclein aggregation and clearance in cellular and animal models of Parkinson's disease. Also shown to improve cognitive performance in young rats (1-5mg/kg) in a dose-dependent manner. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| Propionaldehyde | Propionaldehyde is a reagent combined with formaldehyde to produce trimethylolethane, a compound important in the production of alkyd resins. Propionaldehyde is also a strong inducer of aneuploidy in cultured Chinese hamster cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 123-38-6. Pack Sizes: 5g, 10g. Molecular Formula: C3H6O. US Biological Life Sciences. | Worldwide |
| Propiophenone 99.5+% (GC) | Propiophenone is an aryl ketone used in the preparation of pharmaceutical and organic compounds. Propiophenone is used in perfumes as well as in the preparation of neurochemical compounds such as ephedrines. Group: Biochemicals. Alternative Names: 1-Phenyl-1-propanone; 3-Phenyl-3-propanone; Ethyl Phenyl Ketone; NSC 16937; Phenyl Ethyl Ketone; Propionylbenzene. Grades: GC. CAS No. 93-55-0. Pack Sizes: 50g, 100g, 250g, 500g, 1Kg. Molecular Formula: C9H10O, Molecular Weight: 134.18. US Biological Life Sciences. | Worldwide |
| Propylene Glycol 2-α-Glucopyranosiduronic Acid Benzyl Ester 2,3,4-Triacetate | Propylene Glycol 2-α-Glucopyranosiduronic Acid Benzyl Ester 2,3,4-Triacetate is an impurity in the synthesis of Propylene Glycol 2-Glucuronide Sodium Salt, which is a metabolite of propylene glycol, used in the synthesis of N-terminal kinase inhibitors with cellular activity. Acts as a solvent for various pharmaceutical compounds. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C23H30O11, Molecular Weight: 482.48. US Biological Life Sciences. | Worldwide |
| Prostaglandin EP2 Receptor Antagonist, TG6-10-1 ( (E) -N- (2- (2- (trifluoromethyl) -1H-indol-1-yl) ethyl) -3- (3, 4, 5-trimethoxyphenyl) acrylamide, EP2 Antagonist, TG6-10-1) | A cell-permeable, 3-acryl-acrylamide derivative that acts as a highly potent, selective, and competitive antagonist of prostaglandin E2 receptor (EP2, Kb = 17.8nM). Exhibits about 300-fold selectivity for the EP2 receptor over human EP3, EP4, and IP receptors, about 100- fold selectivity over human EP1, 25-fold selectivity against human FP and TP, and 10-fold selectivity against human DP1 receptors. Does not affect the activity of about 40 enzymes, ion channels, receptors, and neurotransmitters even at higher concentrations (10uM). Shown to significantly reduce the induction of several inflammatory cytokines and chemokines and reduces the opening of blood-brain barrier during neuronal inflammation. Displays good pharmacokinetic properties with a half-life of 1.6 h and brain to plasma ratio of 1.6 in a murine model (5mg/kg i.p.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O?. US Biological Life Sciences. | Worldwide |
| Prostaglandin I2, Sodium Salt (PGI2, Prostacyclin) | Potent vasodilatory prostaglandin produced by the endothelium. Induces vasodilation, stimulates cAMP formation. Exhibits cytoprotective and fibrinolytic properties. Group: Biochemicals. Grades: Highly Purified. CAS No. 61849-14-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Pro-survival Compound, DDD00033325 | A cell-permeable, pyrrolidine small molecule that promotes single human embryonic stem cell survival up to 20-fold over background (EC50=3.9uM), with equal or higher potency than Y-27632 in 5 cell lines (SA461, SA181, SA167, SA121 and SA002) tested at 10uM. An in vitro high-content screening assay, which profiles a panel of more than 70 protein kinases, indicates that this small molecule is more selective than Y-27632 and only displays an inhibitory effect toward ROCK2 (> 83% inhibition, ROCK1 was not included in the panel) and PRK2 (76% inhibition) at 10uM. Furthermore, it exhibits less cytotoxicity at a greater concentration of 30uM than Y-27632 without marked adverse effects for up to 120 hours. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?, Molecular Weight: 293.37. US Biological Life Sciences. | Worldwide |
| Proteasome Inhibitor XXI, Z-LLLL-SF (Cbz-Leu-Leu-Leu-Leu-Psi-[CH2SO2]-F, Cbz-Leu4-SF, Cbz-LLLL-SF, Z-Leu4-SF, Z-L4-SF) | A cell-permeable tetrapeptidyl sulfonyl fluoride -based irreversible proteasome inhibitor that selectively inhibits the hydrolysis of Suc-LLVY-AMC by the beta5 chymotrypsin-like activity (IC50 = 7nM using yeast 20S proteasome), while exhibiting much reduced potency against Z-LLE-AMC hydrolysis by the beta1 caspase-like activity or Z-LLR-AMC hydrolysis by the beta2 trypsin-like activity (29% and 75% inhibition, respectively, with 200uM inhibitor). One hour inhibitor treatment at 5uM in HEK cultures is shown to completely abolish beta5 labeling by the proteasome probe MV151, while only partial MV151 blockage is seen with beta1 and beta2 at an inhibitor concentration of 50uM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??FN?O?S. US Biological Life Sciences. | Worldwide |
| Protein MW Marker, Unstained, 10-70kD | Protein Molecular Weight Marker, Unstained. Group: Molecular Biology. Pack Sizes: 15ul. US Biological Life Sciences. | Worldwide |
| Prucalopride Succinate-13CD3 | Prucalopride Succinate-13CD3 is the labeled analogue of Prucalopride Succinate (P838950). Prucalopride is a selective 5-HT4 receptor agonist used effective for chronic constipation, but is not currently approved in the U.S. Prucalopride is approved for the treatment of chronic constipation in Europe. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C2113CH29D3ClN3O7, Molecular Weight: 489.97. US Biological Life Sciences. | Worldwide |
| Psammaplin A | Antibiotic. Caffeine-like Ca2+ releaser in heavy sarcoplasmic reticulum (HSR). Antifungal. Chitinase inhibitor. DNA methyltransferase inhibitor. Histone deacetylase (HDAC) inhibitor. Anticancer compound. Angiogenesis suppressor. Group: Biochemicals. Alternative Names: (α E, α 'E) -N, N'- (Dithiodi-2, 1-ethanediyl) bis[3-bromo-4-hydroxy-α - (hydroxyimino) benzenepropanamide]; (E,E)-Psammaplin A; Bisprasin; Psammaplin A; UVI 5000; (E,E)-N,N'-(Dithiodi-2,1-ethanediyl)bis[3-bromo-4-hydroxy-α-(hydroxyimino)-benzenepropanamide]. Grades: Highly Purified. CAS No. 110659-91-1. Pack Sizes: 100ug, 500ug. Molecular Formula: C??H??Br?N?O?S?. US Biological Life Sciences. | Worldwide |
| Pseudoanguillosporin A | Antifungal. Respiration inhibitor. Inhibits mitochondrial respiration in fungi. Binds at the Q0-center on cytochrome b and blocks the electron transfer between cytochrome b and cytochrome c1. Group: Biochemicals. Alternative Names: (R)-3-Heptyl-5-methylisochroman-6,8-diol. Grades: Highly Purified. CAS No. 1159392-22-9. Pack Sizes: 500ug, 1mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
| Pseudolaric Acid B | Antifungal and antifertility compound. Antitumor compound. PPARalpha signaling agonist. Angiogenesis inhibitor. Apoptosis and autophagy inducer. Microtubule-destabilizing agent. Anti-inflammatory. Inhibits NF-kappaB and p38 signaling. Immunosuppressive. Group: Biochemicals. Alternative Names: NSC 615488; O-Acetylpseudolaric Acid C; Pseudolaric Acid B; Pseudolarix Acid B; [3R- [3α (1E, 3E) , 4α , 4aα , 9aα ]]-4a- (Acetyloxy) -3- (4-carboxy-1, 3-pentadienyl) -3, 4, 4a, 5, 6, 9-hexahydro-3-methyl-1-oxo-1H-4, 9a-Ethanocyclohepta [c]pyran-7-carboxylic Acid 7-Methyl Ester; (3R, 4S, 4aS, 9aR) -4a- (Acetyloxy) -3- [ (1E, 3E) -4-carboxy-1, 3-pentadienyl]-3, 4, 4a, 5, 6, 9-hexahydro-3-methyl-1-oxo-1H-4, 9a-Ethanocyclohepta [c]pyran-7-carboxylic Acid 7-Methyl Ester. Grades: Highly Purified. CAS No. 82508-31-4. Pack Sizes: 100ug, 1mg. US Biological Life Sciences. | Worldwide |
| Pseurotin D | Isomeric to pseurotin A. Anticancer and antiparasitic compound. Apomorphine antagonist. Neuroleptic agent. Inhibitor of IgE production. Group: Biochemicals. Grades: Highly Purified. CAS No. 77409-68-8. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??NO?. US Biological Life Sciences. | Worldwide |
| Psicofuranine | Nucleoside antibiotic. Antitumor compound. Xanthosine monophosphate (XMP) aminase inhibitor. Antimetabolite of the purine biosynthesis. Group: Biochemicals. Alternative Names: 1'-C- (Hydroxymethyl) adenosine; 1'- (Hydroxymethyl) adenosine; 9- β-D-Psicofuranosyl-6-aminopurine; 9- β-D-Psicofuranosyladenine; Angustmycin C; NSC 53104; Psicofuranine; 9- β-D-psicofuranosyl-adenine; 9- β-D-Psicofuranosyl-9H-purin-6-amine. Grades: Highly Purified. CAS No. 1874-54-0. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| Pterostilbene | A natural stilbenoid related to Resveratrol. Displays anti-oxidative, anti-cancer, anti-hypercholesterolemia, and anti-hypertriglyceridemia properties. Pterostilbene alters gene expression in pancreatic cancer and increases the antiproliferative markers cytochrome C, Smac/DIABLO, and MnSOD/antioxidant activity. It was also shown to inhibit phosphorylated STAT3, a marker of accelerated tumorigenesis, and decrease pancreatic tumor growth in vivo. Group: Biochemicals. Alternative Names: 4-[ (E) -2- (3, 5-Dimethoxyphenyl) ethenyl]phenol; 3',5'-Dimethoxy-4-stilbenol. Grades: Highly Purified. CAS No. 537-42-8. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| (-)-Pyrenophorol | Phytotoxic, antifungal and antihelmintic. Prolylendopeptidase inhibitor. Group: Biochemicals. Alternative Names: Helmidiol, Pyrenophorol, (3E,5S,8R,11E,13S,16R)-5,13-Dihydroxy-8,16-dimethyl-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione. Grades: Highly Purified. CAS No. 155326-45-7 and 22248-41-5. Pack Sizes: 500ug, 1mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
| Pyrethrum Extract (Technical Grade) | Pyrethrum Extract is used as a component in pesticides and insecticides. Pyrethrum Extract is a sum of a mixture of six various pyrethrine compounds, which are derived from Chrysanthemum cinerariifolium plants. Group: Biochemicals. Grades: Purified. CAS No. 8003-34-7. Pack Sizes: 5mg, 10mg. Molecular Formula: N/A. US Biological Life Sciences. | Worldwide |
| Pyroxamide (N1-hydroxy-N8-3-pyridinyl-octanediamide) | Pyroxamide is a potent inhibitor of histone deacetylase 1 (HDAC1) (IC50=100nm). It induces growth suppression and cell death of certain types of cancer cells in culture. Group: Biochemicals. Grades: Highly Purified. CAS No. 382180-17-8. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Pyrrolcarbonyltaloside (1-O-(Pyrrolylcarbonyl)-6-desoxy-alpha-L-talopyranoside) | Antibiotic that shows weak cytotoxic activity against different tumor cell lines and shows antiparasitic activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 912539-02-7. Pack Sizes: 1mg. Molecular Formula: C??H??NO?. US Biological Life Sciences. | Worldwide |
| Pyruvate Kinase Activator (N-(4-Chloro-3-fluorophenyl)-7-fluoro-2-oxo-1,2,3,4-tetrahydroquinoline-6-sulfonamide, PKM2 Activator I) | A cell-permeable and biologically stable (t1/2 = 277.2 and 117.5 min., respectively, in human and mouse liver microsome preparation) tetrahydroquinoline-sulfonamide that enhances the donor PEP, but not the acceptor ADP, substrate affinity toward pyruvate kinase isoform PKM2 (Km = 0.4 vs. 1.9 mM with or without 10uM activator) and acts as a potent PKM2-selective activator (AC50 = 90nM using rhPKM2; ACmax = 88%), displaying much reduced activity toward PKL (<25% at 57uM) and no effect toward PKM1 or PKR. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??ClF?N?O?S, Molecular Weight: 372.8. US Biological Life Sciences. | Worldwide |
| Quercetin 3-O-α-L-Arabinopyranoside | Quercetin 3-O-α-L-Arabinopyranoside is a derivative of Quercetin (Q509500), a flavonoid with anticancer activity. It is a mitochondrial ATPase and phosphodiesterase inhibitor. It Inhibits PI3-kinase activity and slightly inhibits PIP kinase activity. Quercetin has antiproliferative effects on cancer cell lines, reduces cancer cell growth via type II estrogen receptors, and arrests human leukemic T cells in late G1 phase of the cell cycle. Group: Biochemicals. Grades: Highly Purified. CAS No. 22255-13-6. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C20H20O11, Molecular Weight: 436.37. US Biological Life Sciences. | Worldwide |
| Quinacrine Dihydrochloride Dihydrate | Quinacrine Dihydrochloride Dihydrate is a phophoslipase A2 inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 6151-30-0. Pack Sizes: 10g, 25g. Molecular Formula: C23H36Cl3N3O3, Molecular Weight: 508.91. US Biological Life Sciences. | Worldwide |
| Quinolactacin A | Antibiotic. Acetylcholinesterase (AChE) inhibitor. Anti-inflammatory compound. Tumor necrosis factor (TNF) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 386211-68-3, 386211-69-4. Pack Sizes: 1mg, 5mg. Molecular Formula: C16H18N2O2, Molecular Weight: 270.3. US Biological Life Sciences. | Worldwide |
| (-)-Quinpirole Hydrochloride (Dopamine D2 Receptor Agonist, Quinpirole, Quinpirole, LY-171,555, LY 171555) | A potent, selective dopamine D2 receptor agonist with a Ki value of 4.8nM. Some D3(Ki = 24nM) and D4 (Ki = 30nM) receptor agonistic action has also been reported. In rat striatum studies in vitro, application of quinpriole inhibited single pulse dopamine overflow in a concentration-dependent manner (IC50 = 32.5nM). Group: Biochemicals. Grades: Highly Purified. CAS No. 85798-08-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Quisqualic Acid (beta-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine, 3-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine) | A potent agonist highly selective for group I (EC50 ≤3uM) over group II and III mGlu receptors (EC50 >40uM) and a potent agonist of AMPA receptors. Often used for inducing excitotoxic lesions of basal forebrain cholinergic neurons and spinal neurons.CAS Number:52809-07-1. Group: Biochemicals. Grades: Highly Purified. CAS No. 52809-07-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Q-VD-OPh (Anhydrous) | Cell permeable, irreversible and non-toxic non-FMK pan-caspase inhibitor with improved potency, stability and toxicity over Z-VAD-FMK. Does not cross-react with cathepsins nor calpains. Non-toxic due to the 2,6- difluorophenoxy methyl (OPh) group. The peptide is not O-methylated to reduce hydrophobicity and to facilitate use in aqueous media. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Used in apoptosis and inflammasome studies. CAS Number:1135695-98-5 (anhydrous). Group: Biochemicals. Alternative Names: Q-Val-Asp-OPh; pan-Caspase Inhibitor; N-(2-Quinolyl)-L-valyl-L-aspartyl-(2,6-difluorophenoxy) methylketone, (3S) -5- (2, 6-Difluorophenoxy) -3-[[ (2S) -3-methyl-1-oxo-2-[ (2-quinolinylcarbonyl) amino]butyl]amino]-4-oxo-pentanoic Acid. Grades: Highly Purified. CAS No. 1135695-98-5. Pack Sizes: 1mg, 3x1mg, 5mg. Molecular Formula: C??H??F?N?O?. US Biological Life Sciences. | Worldwide |
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