USBiological 4 - Products
Worldwide
Our biochemicals, antibodies, recombinant proteins, cell culture media and molecular biology kits are used in virtually all scientific applications.From affordable research quantities to larger bulk amounts.
| Product | Description | |
|---|---|---|
| Okadaic acid, Ammonium Salt (Halochondrine A, Ammonium, OA) | An ammonium salt form of the protein phosphatase inhibitor Okadaic acid with somewhat greater stability than the free acid when stored in organic solvents. Group: Biochemicals. Grades: Highly Purified. CAS No. 155716-06-6. Pack Sizes: 100ug. US Biological Life Sciences. |  Worldwide |
| Okadaic acid, Potassium Salt (Halochondrine A, Potassium, OA) | Potassium salt form of the protein phosphatase inhibitor Okadaic acid with somewhat greater stability than the free acid when stored in organic solvents. Group: Biochemicals. Grades: Highly Purified. CAS No. 155751-72-7. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Okadaic Acid, Prorocentrum sp. (OA) | An ionophore-like polyether derivative of a C38 fatty acid compound that has tumor promoting properties. Potent inhibitor of protein phosphatase 1 (IC50=10-15nM) and protein phosphatase 2A (IC50=0.1nM). Does not affect the activity of tyrosine phosphatases, alkaline phosphatases, or acid phosphatases. Useful for the study of protein phosphatases in cell extracts as well as in intact cells. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF7) and in myeloid cells but inhibits glucocorticoid-induced apoptosis in T cell hybridomas. Has marked contractile effects on smooth muscle and heart muscle. Implicated as causative agent of diarrhetic shellfish poisoning. Group: Biochemicals. Grades: Highly Purified. CAS No. 78111-17-8. Pack Sizes: 25ug, 100ug. US Biological Life Sciences. | Worldwide |
| Okadaic acid, Sodium Salt (OA, Halochondrine A, Sodium Salt) | Sodium salt form of the protein phosphatase inhibitor Okadaic acid with somewhat greater stability than the free acid when stored in organic solvents. Group: Biochemicals. Grades: Highly Purified. CAS No. 209266-80-8. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Oleyl Oleate | Oleyl Oleate is a synthetic analog of jojoba oil. Used as a wax ester for various applications. Group: Biochemicals. Grades: Highly Purified. CAS No. 3687-45-4. Pack Sizes: 500mg, 5g. Molecular Formula: C36H68O2, Molecular Weight: 532.919999999999. US Biological Life Sciences. | Worldwide |
| Ophiobolin A (Cochliobolin A, Ophiobalin, NSC 114340) | Cell permeable, irreversible calmodulin antagonist. Acts by covalently binding to a lysine-rich inhibitory site. Inhibits by blocking the activation of the Ca2+/calmodulin-dependent phosphodiesterase. Herbicidal mycotoxin. Phytotoxic, antifungal, antibacterial and nematocidal compound. Anticancer compound. Shown to induce paraptosis-like cell death. Shown to inhibit P-glycoprotein-mediated transport. Group: Biochemicals. Grades: Highly Purified. CAS No. 4611-5-6. Pack Sizes: 100ug, 1mg. US Biological Life Sciences. | Worldwide |
| o-Toluidine Chloride | o-Toluidine Chloride is a carcinogenic and toxic aromatic amine contained in hair dye, henna and dyed hair samples. Prilocaine USP Related Compound A. Group: Biochemicals. Grades: Highly Purified. CAS No. 636-21-5. Pack Sizes: 50mg, 1g. Molecular Formula: C7H10ClN. US Biological Life Sciences. | Worldwide |
| Oxandrolone | A synthetic, anabolic steroid. Used to promote muscle growth and combat involuntary weight loss. It has also been used to treat cases of osteoporosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 53-39-4. Pack Sizes: 1mg, 5mg. Molecular Formula: C19H30O3. US Biological Life Sciences. | Worldwide |
| Oxazolidine Cabazitaxel | Oxazolidine Cabazitaxel is an impurity of Cabazitaxel (C046500) which is a novel semi-synthetic taxane with antitumor activity used for the treatment of castration-resistant prostate cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 1373171-12-0. Pack Sizes: 50mg, 500mg. Molecular Formula: C48H61NO14, Molecular Weight: 876. US Biological Life Sciences. | Worldwide |
| OXE-R-Gbg Coupling Modulator, Gue1654 (7- (Methylthio) -2- ( (2, 2-diphenylacetyl) amino) benzo[1, 2-d: 4, 3-d]bisthiazole, N-(7-(Methylsulfanyl)[1, 3]thiazolo[4, 5-g][1, 3]benzothiazol-2-yl)-2, 2-diphenylacetamide) | A membrane-permeant amidobenzobisthiazolo compound that modulates OXE-R-G-beta-gamma coupling upon receptor stimulation via direct OXE-R interaction, without affecting preexisting OXE-R-Galpha-beta interaction. Selectively inhibits OXE-R-G-beta-gamma coupling-mediated, but not OXE-R-G-alpha-mediated, downstream cellular signalings (Effective Conc. 1 to 30uM), displaying no inhibitory activity against cellular functions mediated by G-alpha or G-beta-gamma when coupled to other GPCRs. Comparing to Gallein, Gue1654 does not exert its activity via direct G-beta-gamma interaction. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??N?OS?. US Biological Life Sciences. | Worldwide |
| Oxidized ATP (oATP, Purinergic Receptor Antagonist, Oxidized ATP, Purinergic Receptor P2X7 Antagonist, Oxidized ATP, Purinergic Receptor Inhibitor, Oxidized ATP, O-ATP) | A 2,3-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X7 purinergic receptors in J774 mouse macrophages. Does not affect P2g receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X7 receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca2+ influx in lymphocytes (100uM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts. Group: Biochemicals. Grades: Highly Purified. CAS No. 71997-40-5. Pack Sizes: 25mg. Molecular Formula: C??H??N?O??P?. US Biological Life Sciences. | Worldwide |
| Oxymetazoline Hydrochloride | Vasoconstrictor, used as a nasal decongestant. An ingredient of Drixin. Oxymetazoline is an agonist of α1- and α2-adrenergic receptors (α1- and α2-ARs; Kds = 6, 320, and 390 nM for α1A-, α1B-, and α1D-ARs, respectively, Ki = 15 nM for α2-AR).1,2 It is also an agonist of the serotonin (5-HT) receptor subtype 5-HT1 (Kds = 4.68, 25.7, and 5.01 nM for 5-HT1A, 5-HT1B, and 5-HT1D, respectively).3 Oxymetazoline increases intracellular calcium levels in CHO cells transfected with the α1A-AR (EC50 = 40.7 nM), but does not increase it measurably in cells transfected with the α1B- or α1D-AR (EC50s = 79.4 and 240 nM, respectively).1 It acts as a partial agonist of the α2-AR in isolated perfused rat heart (IC50 = 63 nM and EC50 = 13.5 nM for norepinephrine release).4,5 Oxymetazoline also acts as an agonist and antagonist of the 5-HT1C receptor in the presence of methiothepin (Kd = 110 nM; Item No. 23138) and clonidine (Kd = 257 Group: Biochemicals. Alternative Names: 3-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol Hydrochloride; 2-(4-tert-Butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoline Hydrochloride; 6-tert-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol Hydrochloride; Hazol; Navasin; Navisin; Nezeril; Oxylazine; Rhinofrenol; Rhinolitan; Sinerol. Grades: Highly Purified. CAS No. 2315-2-8. Pack Sizes: 100mg, 500mg, 1g, 5g. Molecular Formula: C??H??ClN?O, Molecular Weight: 296.84. US Biological Life Sciences. | Worldwide |
| Oxymorphinone | Oxymorphinone is a major metabolite of Morphine (M652290). Group: Biochemicals. Grades: Highly Purified. CAS No. 41135-98-2. Pack Sizes: 10mg, 100mg. Molecular Formula: C17H17NO4. US Biological Life Sciences. | Worldwide |
| Oxytocin Receptor Antagonist, MSC1630296 (OT-R Antagonist, 3- (4- (N- (4-chlorophenyl) -N- (2-oxo-2- (2- (2-oxoindolin-3-ylidene) hydrazinyl) ethyl) sulfamoyl) phenyl) -N- (3- (dimethylamino) propyl) propanamide, Fumarate Salt) | A tertiary sulfonamide-based compound that acts as a high-affinity oxytocin (OT) receptor-selective antagonist (Ki = 650 and 670pM in 125I-OVTA-competitive binding assays using human and rat OT-R, respectively), while displaying 65-, 245-, and 23,000-fold reduced affinity, respectively, toward human vassopressin receptors V1a, V2, and V1b. Shown to effectively inhibit OT- (10nM) induced Ca2+ mobilization in hOT-R-expressing HEK293-EBNA cells (IC50 = 14nM) in vitro and OT-stimulated uterine contractions in rats (1.4 -10mg/kg p.o. or 30mg/kg p.o.) in vivo. Product is supplied as a fumarate salt for enhanced aqueous solubility (20 and 10mg/ml, respectively, in water and HBSS). Group: Biochemicals. Grades: Purified. Pack Sizes: 2mg. Molecular Formula: C??H??ClN?O?S.C?H?O?. US Biological Life Sciences. | Worldwide |
| p21-Activated Kinase Inhibitor II, PF-3758309 (PAK Inhibitor II, PF3758309, (S)-N-(2-(Dimethylamino)-1-phenylethyl)-6,6-dimethyl-3-(2-methylthieno[3,2-d]pyrimidin-4-ylamino)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide) | A cell-permeable pyrrolopyrazole that acts as a potent inhibitor against p21-activated kinases (Ki innM/[ATP] inuM = 13.7/200, 18.7/40, 18.1/80. 17.1/72, respectively, in PAK1, PAK4, PAK5, PAK6 kinase assays; IC50 = 190 and 99nM against PAK1 and PAK3, respectively) by directly targeting the kinase ATP-binding site in a reversible manner (Kd = 4.5nM using rhPAK4300-591 kinase domain). Inhibits PAK4-dependent cellular signaling (IC50 = 24.2nM against TNFalpha-stimulated NF-kappa-B activity in HEK293T) and proliferation (IC50 = 0.24 and 27nM, respectively, against HCT116 and A549 colonies formation) in vitro and the growth of human tumors in nude mice in vivo (10 to 25mg/kg; b.i.d. p.o). Group: Biochemicals. Grades: Highly Purified. CAS No. 898044-15-0. Pack Sizes: 5mg. Molecular Formula: C??H??N?OS. US Biological Life Sciences. | Worldwide |
| P2X Antagonist III (Purinergic Receptor P2X Antagonist III, N- ( (4- (4-Phenylpiperazin-1-yl) tetrahydro-2H-pyran-4-yl) methyl) -2- (phenylthio) nicotinamide) | A phenylthio-nicotinamide that acts as a high affinity P2X7 antagonist (pKi = 8.7 and 7.9, respectively, against 30nM A-804598 for rat and human P2X7 binding) and potently inhibits P2X7-dependent cellular Ca2+ mobilization (pIC50 = 8.3, 7.5, and 7.2, respectively, using 1321N1 expressing human, mouse, or rat P2X7; drug added 0.5 h prior to 3 min 0.25 mM BzATP stimulation), while exhibiting much reduced or little potency toward a panel of 50 ion channels, transporters, and receptors. Although not suitable for oral dosing due to high hepatic extraction ratios, effective delivery and brain P2X7 occupancy can be achieved via s.c. dosing in rats (30mg/kg) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| P2Y Antagonist II (1- (2- (2-tert-Butylphenoxy) pyridin-3-yl) -3- (4- (trifluoromethoxy) phenyl) urea, Purinergic Receptor P2Y Antagonist II) | A phenoxypyridinyl-phenylurea that acts as a highly selective P2Y1 antagonist (Ki = 6nM against 0.5nM 2-MeS-ADP for human P2Y1 binding), while displaying much reduced or no affinity toward other P2Y family GPCRs (Ki = ≥2.5uM toward hP2Y14; Ki >15uM toward human P2Y2, P2Y6, P2Y11, and P2Y12). Effectively inhibits 2.5uM ADP-induced platelet aggregation in vitro (IC50 = 2.1uM) and reduces FeCl2-induced carotid artery blood clot formation in anesthetized rats in vivo (10mg/kg/h i.v. infusion) with much less effect toward prolonging cuticle and mesenteric bleeding time when compared to another P2Y12 antagonist Clopidogrel. Pharmackinetic studies reveal only moderate oral bioavailability in rat. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O?. US Biological Life Sciences. | Worldwide |
| p300/CBP Inhibitor VI, L002 (4- (4-Methoxyphenyl sulfonyl oxyimino) -2, 6-di methyl -2, 5-cyclohexadien-1-one, GCN5 Inhibitor III, Histone Acetyltransferase Inhibitor IX, PCAF Inhibitor IV) | A cell-permeable phenyl sulfonyl oxyimi nocyclohexadienone compound that acts as a potent, selective, and reversible inhibitor of p300 histone acetyl transferase (IC50 = 1.98uM). Shown to occupy Ac-CoA binding pocket of p300, and less potent to CBP, PCAF, GCN5 and GNAT. Suppresses Histone H3 and H4 acetylation in triple negative breast cancer cell line MDAMB-468 as well as in HCT116 cell line and blocks p300-mediated STAT3 phosphorylation in pancreatic cancer cell line MIA Paca-2. Does neither inhibit the activities of histone deacetylases 1, 6, and 11 nor 8-diverse histone methyltransferases tested (DOT1, EZH1, G9a, PRMT1, SETD2, SET7-9, SMYD2, and SUV39H2). Reported to suppress tumor growth in mice bearing tumor xenografts of MDAMB-468 cell line (at 500ug/100ul, i.p. twice a week). Group: Biochemicals. Grades: Highly Purified. CAS No. 321695-57-2. Pack Sizes: 10mg. Molecular Formula: C??H??NO?S. US Biological Life Sciences. | Worldwide |
| p38 MAP Kinase Inhibitor XI (4-(2,4-Difluorophenyl)-8-(2-methylphenyl)-1,7-naphthyridine-7-oxide, 4-(2,4-Difluorophenyl)-8-o-tolyl-1,7-naphthyridine-7-oxide) | A cell-permeable naphthyridine N-oxide compound that acts as a potent, reversible p38alpha MAP kinase inhibitor (IC50 = 68nM) and exhibits excellent selectivity among 54-kinases. It acts on the ATP-binding site plus an adjacent hydrophobic pocket. Exhibits desirable ADME (Absorption, Distribution, Metabolism, and Excretion) profile with good microsomal stability, low toxicity, and low reactivity towards cytochrome P450 isozymes. Shown to inhibit lipopolysaccharide-induced TNF-alpha production in a dose-dependent manner (ED50 of 0.5mg/kg). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| p38 MAP Kinase Inhibitor XIX, Skepinone-L ((2-(2,4-Difluorophenylamino)-7-[2R-,3-dihydroxypropoxy]-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one)) | A cell-permeable phenylamino-dibenzosuberone-diol with a rigid molecular structure specifically designed to target hydrophobic region I in p38alpha & p38beta, but not in other kinases with bulky entrance-blocking gatekeeper residues. Shown to selectively inhibit p38alpha (IC50 = 5nM; [ATP] = 100uM) and p38beta (97% inhibition at 1uM), while exhibiting little affinity toward 400 other kinase constructs, including p38delta, p38upsilon, Erk1/2/3/4/5/8, JNK1/2/3, and MEK1/2/3/4/6. Shown to prevent cellular HSP27 Ser82 phosphorylation upon p38 activation by Anisomycin in HeLa (IC50 = 25nM) or by TNF-alpha in THP-1 cultures. Unlike the ATP-binding site-targeting BIRB 796 and SB 203580, Skepinone-L does not inhibit JNK-mediated c-Jun or ERK-dependent CREB phosphorylation in THP-1 cultures. Oral administration to D-Gal-sensitized mice is reported to greatly reduce plasma TNF-alpha production upon LPS challenge (by 77%; 3mg/kg p.o.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| PACAP-27, Amide, Sheep (Pituitary Adenylate Cyclase Activating Polypeptide, HSDGIFTDSYSRYRKQMAVKKy l AAVL-NH2) | Increases cAMP levels in a dose-dependent manner (EC50=4.7nM). Increases tyrosine hydroxylase expression in chromaffin cells.CAS No:127317-03-7. Group: Biochemicals. Grades: Highly Purified. CAS No. 127317-03-7. Pack Sizes: 0.5mg. Molecular Formula: C???H???N??O??S, Molecular Weight: 3147.7. US Biological Life Sciences. | Worldwide |
| Palitantin (NSC 246119) | Antiprotozoal (Leishmania). Antifungal. Group: Biochemicals. Grades: Highly Purified. CAS No. 15265-28-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Palladium (10% on Activated Carbon) (~50% water by weight) | Palladium is a transition metal element used in catalytic reactions involving processes such as hydrogenation. Group: Biochemicals. Grades: Highly Purified. CAS No. 7440-5-3. Pack Sizes: 100mg, 500mg. Molecular Formula: Pd, Molecular Weight: 106.42. US Biological Life Sciences. | Worldwide |
| Palmarumycin C3 | Rasfarnesyltransferase inhibitor. Antifungal, antibacterial and herbicidal. Structurally unique natural products. The basic structure of palmarumycin C1 can be modified by a number of hydroxylation, oxygenation, dehydrogenation and chlorination steps. Antioxidant. Group: Biochemicals. Alternative Names: (1aR, 7aS) -1a, 7a-Dihydro-3, 6-dihydroxyspiro [naphth [2, 3-b]oxirene-2 (7H) , 2-naphtho [1, 8-de] [1, 3]dioxin]-7-one; (1aR,7aS)-1a,7a-Dihydro-3,6-dihydroxy-spiro[naphtho[1,8-de]-1,3-dioxin-2,2(7H)-naphth[2,3-b]oxiren]-7-one. Grades: Highly Purified. CAS No. 159934-11-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
| Palmarumycin C3-5,8-quinone | Spirobisnaphthalene derivative (unpublished). Oxidation product of palmarumycin C3. This compound has not yet been thoroughly tested for its biological activity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Palmitoylethanolamide | An endogenous lipid that acts as a selective agonist for GPR55 receptors (EC50 = 4, 19 800 and > 30 000nM at GPR55, CB2 and CB1 receptors respectively). Producing robust anti-inflammatory actions by activating PPAR-alpha (EC50 = 3uM).Primary Target:GPR55 receptor. Group: Biochemicals. Alternative Names: N- (2-Hydroxyethyl) hexadecanamide, PEA, Palmidrol. Grades: Highly Purified. CAS No. 544-31-0. Pack Sizes: 100mg, 250mg, 500mg, 1g. Molecular Formula: C??H??NO?, Molecular Weight: 299.49. US Biological Life Sciences. | Worldwide |
| Pancuronium Dibromide (1,1'-(3alpha,17beta-Dihydroxy-2alpha,5beta-androstan-2-beta,16beta-ylene) bis[1-methylpiperidinium] Diacetate Dibromide, Nicotinic Acetylchorine Receptor Antagonist, Pancuronium Dibromide, nAChR Antagonist, Pancuronium Dibromide) | A highly potent competitive antagonist selective for nAChRs (IC50 = 5.5nM). A very potent non-depolarizing skeletal muscle relaxant but no sedative or analgesic effects. Group: Biochemicals. Grades: Highly Purified. CAS No. 15500-66-0. Pack Sizes: 10mg. Molecular Formula: C??H??N?O? Br?. US Biological Life Sciences. | Worldwide |
| Panobinostat (LBH-589, LBH589, LBN-589, NVP-LBH589) | Panobinostat (LBH589) is a highly potent inhibitor of both histone deacetylase 1 (HDAC1) activity and tumor cell proliferation in vitro. The IC50 values of HDAC isozymes HDAC1-IP Ac-H4, HDAC8, MALunselective, B61HDAC1 and B12HDAC6 are 0.23±0.06, 283±29, 75±4, 47±5 and 89±12nm, respectively. And to A2780 proliferation, IC50 value is 4.6±1.8nm. Group: Biochemicals. Grades: Highly Purified. CAS No. 404950-80-7. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Pantothenic Acid (Technical Grade, Contains Lactone) | Pantothenic Acid is a member of the B complex vitamins; essential vitamin for the biosynthesis of coenzyme A in mammalian cells. Occurs ubiquitously in all animal and plant tissue. The richest common source is liver, but jelly of the queen bee contains 6 times as much as liver. Rice bran and molasses are other good sources. Group: Biochemicals. Grades: Purified. CAS No. 79-83-4. Pack Sizes: 1g, 10g. Molecular Formula: C9H17NO5. US Biological Life Sciences. | Worldwide |
| Paprotrain ((Z) a-(3-Pyridinylmethylene)-1H-indo le-3-acetonitrile) | Paprotrain ((Z) a-(3-Pyridinylmethylene)-1H-indo le-3-acetonitrile). Group: Biochemicals. Grades: Highly Purified. CAS No. 57046-73-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Papyracillic Acid A | Antibiotic. Exists in an equilibrium of diastereomers. Group: Biochemicals. Alternative Names: (5S,7R,8S)-7-Hydroxy-4-methoxy-7,8-dimethyl-9-methylene-1,6-dioxaspiro[4.4]non-3-en-2-one. Grades: Highly Purified. CAS No. 960148-59-8. Pack Sizes: 500ug, 1mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
| Paroxetine Hydrochloride (5-HT transporter, Paroxetine, Paxil) | A very potent uptake inhibitor highly selective for 5-HT transporter (Ki = 0.065nM and 0.05nM for human and rat 5-HT transporters, respectively). A popular antidepressant drug of the SSRI type. Used to treat major depression, obsessive-compulsive disorder, panic disorder, social anxiety, posttraumatic stress disorder, generalized anxiety disorder and vasomotor symptoms. Group: Biochemicals. Grades: Highly Purified. CAS No. 110429-35-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| (±)-PD 128907 Hydrochloride (Dopamine D3 Receptor Agonist, PD 128,907, PD 128907, PD128907) | Selective dopamine D3 receptor agonist (Ki = 2.3nM) with an 18-fold selectivity over long dopamine receptors (D2L) and exhibited only weak affinity for D4.2 receptors (Ki = 169nM). Commonly used to reproduce cocaine's discriminative stimulus effects and also in peripheral systemic studies of hypertension. Group: Biochemicals. Grades: Highly Purified. CAS No. 112960-16-4. Pack Sizes: 5mg. Molecular Formula: C??H??NO? HCl. US Biological Life Sciences. | Worldwide |
| PD 168077 Maleate (D4 Dopamine Receptor Agonist, PD 168077 Maleate, PD168077, PD-168077) | A selective D4 dopamine receptor agonist (Ki = 8.7nM, EC50 = 8.3nM). Suitable for central and peripheral delivery. Used in studies of penile erection, learning and memory. Exibits some binding affinity towards human D2 and D3 Receptors (Ki = 2.8uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 630117-19-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PDE10A Inhibitor, Cpd15 (Phosphodiesterase 10A Inhibitor, (6-chloro-3,8-dimethyl-1H-pyrazolo[3,4-b]quinolin-4-yl)(2-methylpyrimidin-5-yl)methanol) | A cell-permeable pyrazoloquinoline compound that acts as a potent phosphodiesterase 10A inhibitor (Ki≤5nM against human PDE10A), while exhibiting >500-fold selectivity over other human PDEs 1-11 and little activity against CYP3A4 (IC50 >20uM) or a panel of 23 kinases (IC50 >30uM). Reported to be orally available in monkey and rat species and be efficacious in reversing nMDAR antagonist (+)-MK-801-induced hyperactivity in a ratsl (MED = 10mg/kg p.o.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??ClN?O. US Biological Life Sciences. | Worldwide |
| PDE4D Inhibitor, GEBR-7b ((E)-3-(cyclopentyloxy)-4-methoxybenzaldehyde, O-2-(2,6-dimethylmorpholino)-2-oxoethyl oxime, GEBR-7b) | A cell permeable, potent, and selective oxime PDE4D inhibitor (IC50=0.67uM) which displays much reduced activities toward other PDE4 isoforms. It is shown to cause a significant 40% increase in extracellular cAMP in the hippocampus of freely moving rats in vivo at 100uM, but has no effect on Ab levels. This compound elicits cognitive enhancement in vivo at the optimum dose of 0.003mg/kg in both mice and rat models, and unlike rolipram, does not cause emesis-like behavior in rodents. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| PDGFRb/RAF Kinase Inhibitor | An orally bioavailable amino-triazole compound that is shown to bind to the inactive conformations of both PDGFRb and Raf kinases (allosteric, Type II inh), and acts as a potent inhibitor of Flt3, Kit, PDGFRa and PDGFRb (=52, 170, 300 and 520nM, respectively) with selectivity over B-Raf, p38a, FGFR2 and VEGFR2 (>10uM) in a multi-kinase panel. Completely blocks the phosphorylations of MEK-1/2 S217/S221, ERK-1/2 T202/Y204 in FGF-stimulated HUVECs, PDGFRb in PDGF-BB-stimulated VSMCs, ERK-1/2 T202/Y204 in 1205Lu-B Raf V600E cells, and C-Raf S338 at 10uM. Reduces FGF-induced angiogenesis in mouse Matrigel model (50mg/kg, i.p., bid) and selectively induces apoptosis in the endothelium; further, suppresses orthotopic renal cell carcinoma growth in mice (100mg/kg, p.o., qd). Group: Biochemicals. Alternative Names: 6- (4- (5- (3- (Trifluoromethyl) phenylamino) -4 H-1,2,4-triazol-3-yl)phenoxy)-2-(methylthio)pyrimidin-4-amine, PDGFR Tyrosine Kinase Inhibitor XXII. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?OS, Molecular Weight: 459.6. US Biological Life Sciences. | Worldwide |
| PDTC (Pyrrolidinedithiocar bamate Ammonium, PDC, APDC) | An antioxidant and an inhibitor of NF-kB; prevents induction of nitric oxide synthase (NOS) by inhibiting translation of NOS mRNA; induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells. Also inhibits breast cancer stem-like cells by blocking the NF-kB activity in MCF7 sphere and MCF7 cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 5108-96-3. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Penicillin DF | Penicillin DF is used to characterize phenylacetate-CoA ligase from Penicillium chrysogenum. Group: Biochemicals. Grades: Highly Purified. CAS No. 4493-18-9. Pack Sizes: 10mg, 50mg. Molecular Formula: C14H22N2O4S, Molecular Weight: 314.399999999999. US Biological Life Sciences. | Worldwide |
| Pentanoic Acid Oxybis(methylene) Ester | Pentanoic Acid Oxybis(methylene) Ester is an polyglycol Ester derived from Valeric Acid (V091420). Group: Biochemicals. Grades: Highly Purified. CAS No. 40657-33-8. Pack Sizes: 100mg, 1g. Molecular Formula: C12H22O5. US Biological Life Sciences. | Worldwide |
| Pentostatin, Adenosine Deaminase Inhibitor, DCF (2-Deoxycoformycin, Pentostatin, S. antibioticus, (8R)-3-(2-deoxy-b-D-erythro- pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol) | A cell-permeable purine nucleoside compound that acts as a highly potent, tight binding transition state analog inhibitor of adenosine deaminase (ADA; Ki=2.5pM against partially purified human erythrocytes, and 0.48 to 9.1nM against rat liver, rat intestine, rat hepatoma and human B cells). Reported to be an immunomodulator and exert selective toxicity towards lymphocytes. Group: Biochemicals. Grades: Highly Purified. CAS No. 53910-25-1. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?, Molecular Weight: 268.3. US Biological Life Sciences. | Worldwide |
| Peptidylprolyl Isomerase F (PPIF) Recombinant, Mouse, Unstained Protein Molecular Weight Marker | Peptidylprolyl Isomerase F (PPIF) Recombinant, Mouse, Unstained Protein Molecular Weight Marker. Group: Molecular Biology. Grades: Highly Purified. Pack Sizes: 15ul. US Biological Life Sciences. | Worldwide |
| (-)-Perillyl Alcohol | (-)-Perillyl Alcohol is a monoterpene that induces apoptosis in colon tumor cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 18457-55-1. Pack Sizes: 10g, 25g. Molecular Formula: C10H16O, Molecular Weight: 152.229999999999. US Biological Life Sciences. | Worldwide |
| Petasol | Eremophilane sesquiterpenoid. Inhibitor of HIV-1 Tat transduction. Phytotoxin. Mycotoxin. Group: Biochemicals. Alternative Names: (+)-Petasol; Sencathenone; 3-Hydroxy-9,11-eremophiladien-8-one, (3S,4aR,5R,6R)-6-hydroxy-4a,5-dimethyl-3-prop-1-en-2-yl-3,4,5,6,7,8-hexahydronaphthalen-2-one. Grades: Highly Purified. CAS No. 64236-38-0. Pack Sizes: 1mg, 5mg. Molecular Formula: C15H22O2. US Biological Life Sciences. | Worldwide |
| PF-562271 | Potent ATP-competitive reversible inhibitor of FAK and Pyk2. PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nm, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nm. PF-562,271 was evaluated against multiple kinases and displays >100X selectivity against a long list of non target kinases. In tests, PF-562,271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion with a calculated EC50 of 93ng/ml using injections. Group: Biochemicals. Grades: Highly Purified. CAS No. 717907-75-0. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C21H20F3N7O3S, Target: FGFR. US Biological Life Sciences. | Worldwide |
| PFKFB3 Inhibitor, 3PO (6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 Inhibitor, 3PO, 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one, (2E)-3-Pyridin-3-yl-1-pyridin-4-ylprop-2-en-1-one) | A cell-permeable dipyridinyl-propenone compound that selectively blocks PFK-2 (6-phosphofructo-2-kinase) activity of PFKFB3 isozyme over PFK-1 (6-phosphofructo-1-kinase) in a mixed-mode manner. Rapidly decreases fructose-2,6-bisphosphate (F-2,6-P2) and 2-deoxyglucose uptake, and lactate secretion; efficiently arrests proliferation of transformed cells (IC50 ~1.4uM in NHBE-ht/LT/ras) and suppresses tumor growth in several xenograft mouse models (70mg/kg, i.p.). The cytostatic and cytotoxic effects of 3PO is shown to be highly sensitive to the intracellular levels of F-6-P (fructose-6-phosphate) and F-2,6-P2. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| PHA-543,613 (N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, Alpha 7 Nicotinic Acetylcholine Receptor (alpha7 nAChR) Agonist, PHA-543613) | A potent agonist highly selective for alpha7 nicotinic acetylcholine receptor (alpha7 nAChR). Bioavaible admitted orally. Widely used in studies of the functional roles of alpha7 nAChR in learning and memory, sensory gating, and cognitive functions as well as Schizophrenia and Alzheimer's disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 478149-53-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| PHCCC ( (E) -1, 1a, 7, 7a-Tetrahydro-7- (hydroxyimino) -N-phenylcyclopropa [b]chromene-1a-carboxamide) | A potent positive allosteric modulator selective for mGlu4 receptors (EC50 = 3uM). Also, a less potent agonist of mGlu6 receptors (EC50 = 15uM). Biologically active admitted systematically. Often used in assessing the functional roles of mGlu4 receptors or group III mGlu receptors in a variety of research areas, such as epileptic seizures, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson's disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 1161205-27-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Phenelzine | Phenelzine is an anti-depressant monoamine oxidase inhibitor (MAOI). Also, it is the free base of Phenelzine Sulfate (P295900), which is a hydrazine derivative that is a non-selective and irreversible monamine oxidase inhibitor (MAOI) and also inhibits GABA-transaminase (GABA-T), markedly increasing brain levels. It is an antidepressant and anxiolytic used in the treatment of major depressive disorder (MDD) as well as other neural disorders. Group: Biochemicals. Grades: Highly Purified. CAS No. 51-71-8. Pack Sizes: 250mg, 500mg. Molecular Formula: C8H12N2, Molecular Weight: 136.19. US Biological Life Sciences. | Worldwide |
| Phenolphthalein Glucuronide, Sodium Salt | Phenolphthalein Glucuronide, Sodium Salt is a substrate for β-glucuronidase. Group: Biochemicals. Grades: Highly Purified. CAS No. 6820-54-8. Pack Sizes: 10mg, 25mg. Molecular Formula: C26H22O10; Na, Molecular Weight: 494.452298999999. US Biological Life Sciences. | Worldwide |
| Phenylacetone | A metabolite of Lisdexamfetamine dimesylate. Group: Biochemicals. Grades: Highly Purified. CAS No. 103-79-7. Pack Sizes: 10mg, 50mg. Molecular Formula: C9H10O. US Biological Life Sciences. | Worldwide |
| Philanthotoxin-7,4 ( (S) -N- (1- ( (7- ( (4-aminobutyl) amino) heptyl) amino) -3- (4-hydroxyphenyl) -1-oxopropan-2-yl) butyramide, Philanthotoxin-74, PhTx-74, AMPA Glutamate Antagonist, Philanthotoxin-7,4) | A potent competitive antagonist highly selective for GluA1, GluA3, and GluA1/A2 subtype AMPA receptors (Ki = 0.168 and 1.6uM for GluA1 and GluA1/A2, respectively). Negligible effect at GluA2 and GluA2/A3 subtype AMPA receptors. Used in studies of circadian rhythm, addition, and sleep. Group: Biochemicals. Grades: Highly Purified. CAS No. 401601-12-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Phloxine B | Phloxine B is a fluorescein photoactive dye. Group: Biochemicals. Grades: Highly Purified. CAS No. 18472-87-2. Pack Sizes: 5g, 10g. Molecular Formula: C20H4Br4Cl4O5 + 2Na, Molecular Weight: 785.6722299. US Biological Life Sciences. | Worldwide |
| Phosphoric Acid Diethyl Ester | Phosphoric acid diethyl ester is an organophosphate that is usually found in pesticides and is known to induce changes in male hormone profile by decreasing serum testosterone and inhibin B levels. Phosphoric acid diethyl ester is also known to negatively affect the health of women and newborns living in agricultural communities. Group: Biochemicals. Grades: Highly Purified. CAS No. 598-02-7. Pack Sizes: 100mg, 500mg. Molecular Formula: C4H11O4P. US Biological Life Sciences. | Worldwide |
| Phosphoric Acid Tributyl Ester-d27 | Isotope labelled Phosphoric Acid Tributyl Ester is used as a solvent in the solvent-detergent method for production of immunoglobulin for inactivation of viruses with lipid envelope on the model of duck hepatitis B virus. It is also used as a ligand in the extraction of lanthanide ions from solid and liquid materials by supercritical CO2. Group: Biochemicals. Grades: Highly Purified. CAS No. 61196-26-7. Pack Sizes: 25mg, 100mg. Molecular Formula: C12D27O4P. US Biological Life Sciences. | Worldwide |
| Phosphorus(V) Oxychloride | High purity Phosphorus(V) Oxychloride is used as an n-type dopant in the semiconductor industry for applications such as solar cell fabrication. Group: Biochemicals. Grades: Highly Purified. CAS No. 10025-87-3. Pack Sizes: 5g, 25g. Molecular Formula: Cl3OP, Molecular Weight: 153.33. US Biological Life Sciences. | Worldwide |
| Photochromic Ion Channel Blocker, QAQ (2, 2- ( (diazene-1, 2-diylbis (4, 1-phenylene))bis (azanediyl))bis (N, N, N-triethyl-2-oxoethanaminium) formate, Quaternary Ammonium-Azobenzene-Quaternary Ammonium) | A membrane-impermeant Na+, K+, and Ca2+ channel blocker that is structurally composed of two azo-linked QX-314 type quaternary amines. Both QX-314 and QAQ are shown to selectively target excitability of nociceptor neurons via TRPV1-dependent cellular uptake. Unlike QX-314, the channel blocking activity of QAQ can be quickly switched on and off via optical cis-to-trans (500nM) and trans-to-cis (320nM) isomerization. Its efficacy as a pain-selective, photochromic anesthetic has been demonstrated in rats in vivo. QAQ cellular uptake can also be achieved by ATP-activated P2X7 receptor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Phthalocyanine | Phthalocyanine is a common macrocylic blue-green dye able to form coordination complexes with many elements on the periodic table. Group: Biochemicals. Grades: Highly Purified. CAS No. 574-93-6. Pack Sizes: 1g, 2.5g. Molecular Formula: C32H18N8, Molecular Weight: 514.54. US Biological Life Sciences. | Worldwide |
| PI 3,4-K Inhibitor, PIK-93 (N- (5- (4-Chloro-3- ( ( (2-hydroxyethyl) amino) sulfonyl) phenyl) -4-methyl-2-thiazolyl) -acetamide) | A cell-permeable phenylthiazole compound that acts as a potent, reversible and ATP-competitive PI 3,4-K family selective inhibitor (IC50=16, 19, 39 and 64nM for p110y, PI 4-KIIb, p110a and DNA-PK, respectively). Moderately inhibits p110d, PI 3-KC2b, hsVPS34, ATM, p110b and PI 4-KIIIa (IC50=0.120, 0.140, 0.320, 0.490, 0.590 and 1.1uM, respectively) with minimal inhibition towards a panel of 36-kinases (IC50>10uM). Shown to block ceramide transfer protein-mediated ceramide traffic between endoplasmic reticulum and Golgi in transfected COS-7 cells at 250nM. Group: Biochemicals. Grades: Highly Purified. CAS No. 593960-11-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| PI 3-K Inhibitor XVIII (p110 beta-G beta gamma Interaction Inhibitor peptide, Cell-permeable, Myr-N-KAAEIASSDSANVSSRGGKKFL PV-NH2) | An N-myristoylated cell-permeable PI 3-K p110 beta-derived G beta-gamma-binding peptide (aa514-537 in p110 beta C2-helical linker region) that prevents G beta-gamma-, but not RTK-, mediated p100 beta activation both in cell-free assays (1uM) and in cultures (30uM in p110 beta/p85/Akt/G beta-gamma-transfected HEK 293E cells) without affecting basal p100 beta activity, p110 beta-Rab5 interaction, nor G beta-gamma-dependent activation of adenylyl cyclase or p101-p110-gamma dimer. The ATP-competitive p110 beta inhibitior TGX-221 can be used in conjunction for studying G beta-gamma dependency of p110 beta-mediated cellular functions. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Piceatannol | Wide range of tyrosine and serine/threonine protein kinase inhibitor, including Syk, p56lck, PKA, PKC, MLCK, CDPK, JNK and PI3K. Inhibits the tyrosine phosphorylation of STAT3 and STAT5. Potent apoptosis inducer. Potent anticancer compound. Suppresses NF-kB activation through IkBalpha kinase inhibition. Activator of human deacetylase SIRT1 (sirtuin 1). Potent antioxidant with anti-proliferative, anti-inflammatory and cardioprotective properties. Neuoprotective. Adipogenesis inhibitor. Promotes glucose uptake, AMPK phosphorylation and GLUT4 translocation. Group: Biochemicals. Grades: Highly Purified. CAS No. 10083-24-6. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
| Piceatannol (trans-Picetannol, Astringenin) | Cell-permeable. Kartogenin promotes the differentiation of multipotent mesenchymal stem cells into chondrocytes (EC50 = 100nM). Displays chondroprotective effects in vitro and is efficacious in two animal models of osteoarthritis. Group: Biochemicals. Alternative Names: trans-3,3',4,5'-Tetrahydroxystilbene. Grades: Highly Purified. CAS No. 10083-24-6. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| PICK1 PDZ Domain Inhibitor, FSC231 ( (E) -Ethyl-2-cyano-3- (3, 4-dichlorophenyl) acryloylcarbamate) | A cell-permeable acryloylcarbamate compound that selectively targets the PDZ (PSD-95/Discs-large/ZO-1 homology) domain of PICK1 (protein interacting with C kinase 1), but not those of PSD-95 (postsynaptic density protein 95) and GRIP1 (glutamate receptor interacting protein 1), effectively competing against dopamine transporter/DAT (Ki ~10uM), GluR2 (Ki ~10uM), and mRluR7a, c-terminus binding to PICK1 PDZ. Shown to accelerate internalized GluR2 surface recycling and suppress both long-term depression and potentiation in rat and murine hippocampal neurons. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Picrocrocin | Picrocrocin is a secondary metabolite of Saffron and has been found to be the taste component of saffron. Group: Biochemicals. Grades: Highly Purified. CAS No. 138-55-6. Pack Sizes: 1mg, 10mg. Molecular Formula: C16H26O7, Molecular Weight: 330.37. US Biological Life Sciences. | Worldwide |
| Pikromycin | Antibiotic. 14-Membered macrolide. Active against Gram-positive bacteria including mycobacteria. Prolyl endopeptidase (PREP) inhibitor.CAS Number:19721-56-3. Group: Biochemicals. Alternative Names: (3R, 5R, 6S, 7S, 9R, 11E, 13S, 14R)-14-Ethyl-13-hydroxy-3, 5, 7, 9, 13-pentamethyl-6-[[3, 4, 6-trideoxy-3-(dimethylamino)- β -D-xylo-hexopyranosyl] oxy] oxacyclotetradec-11-ene-2, 4, 10-trione; Oxacyclotetradecane, picromycin deriv.; Albomycetin; Amaromycin; Antibiotic B 62169A; Pikromycin; [3R-(3R*, 5R*, 6S*, 7S*, 9R*, 11E, 13S*, 14R*)]-14-Ethyl-13-hydroxy-3, 5, 7, 9, 13-pentamethyl-6-[[3, 4, 6-trideoxy-3-(dimethylamino)- β -D-xylo-hexopyranosyl] oxy] oxacyclotetradec-11-ene-2, 4, 10-trione. Grades: Highly Purified. CAS No. 19721-56-3. Pack Sizes: 1mg, 5mg. Molecular Formula: C28H47NO8 , Molecular Weight: 525.7. US Biological Life Sciences. | Worldwide |
| PIM3 Kinase Inhibitor VII, M-110 (N- (1- (4-Chloro-2-hydroxyphenyl) propylidene) -2- ( (3-morpholinopropyl) amino) isonicotinohydrazide) | A cell-permeable hydroxyphenyl-propylidene-benzohydrazide compound that acts as a potent, ATP-competitive (Ki = 0.3uM), and highly isoform-selective PIM inhibitor (IC50 = 2.5, 2.5, and 0.047uM against PIM1, PIM2, and PIM3, respectively; [ATP] = 10uM), while affecting CK2alpha2 only at much higher concentrations (IC50 = 5uM, [ATP] = 10uM) and exhibiting little or no activity against a panel of 258 other kinases (<40% inhibition at 5uM). Shown to inhibit PIM3-dependent STAT3 Tyr705 phosphorylation in DU-145 prostate cancer and MiaPaCa2 pancreatic cancer cells (by 73% and 83%, respectively; 10uM for 18h), while displaying little effect toward STAT3 Tyr694 phosphoylation in 22RV1 cultures. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PIM-Kinase Inhibitor IX, SGI-1776 (N- ( (1-Methylpiperidin-4-yl) methyl) -3- (3- (trifluoromethoxy) phenyl) imidazo[1, 2-b]pyridazin-6-amine, 2H2SO4) | A cell-permeable imidazopyridazine compound that acts as a potent, reversible and ATP-competitive inhibitor of Pim-1,2,3, Flt-3 and haspin kinase activities (IC50=7, 363, 69, 44 and 34nM, respectively) with moderate (40% inhibition at 1uM for c-kit) to excellent selectivity over CDKs, Aurora, Chk1, IKK, JNK, Abl, Raf, PKA, PKC and PI 3-K among 300-kinases. Shown to inhibit RNA synthesis, block phosphorylation of c-Myc-Ser62 and STAT3-Tyr705, and decrease c-Myc and Mcl-1 protein levels; cause cell cycle arrest and induce apoptosis in CLL lymphocytes and in AML cells, and efficiently arrest the growth of several prostate cancer cells (IC50 <10uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O; 2H?SO?, Molecular Weight: 601.6. US Biological Life Sciences. | Worldwide |
| PIM Kinase Inhibitor VIII, R8-T198wt (NH2-GGGRRRRRRRRGC ~KKPGLRRRQT-CO2H, cpm-P27Kip1189-198) | The human p27Kip1 C-terminus PIM-1 phosphorylation site- (Thr198) containing sequence is synthesized with an N-terminal Arg octamer/R8-containing sequence to facilitate its use as a cell-permeable, substrate-competitive PIM-1 inhibitor. Reported to completely prevents human prostate carcinoma DU145-derived tumor expansion for up to 17 days (0.5umol/animal on days 0 & 5; intratumoral injection) in mice in vivo when combined with a single Taxol dosage on day zero (60mg/kg; i.p.). Studies using FITC-conjugated R8-T198wt demonstrate that R8-T198wt-induced cell cycle arrest and apoptosis in PIM-1-expressing DU145 cells are direct consequences of inhibition of PIM-1-mediated p27Kip1 Thr198 and Bad Ser112 phosphorylation, respectively. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Pimprinine (3-(2-Methyl-5-oxazolyl)-1H-indole, Antibiotic WS-30581C, NSC80793, 5-(3-Indoyl)-2-methyloxazole) | Indole alkaloid. Monoamine oxidase inhibitor (MAOI). Antiepileptic (anticonvulsant) compound. Inhibitor of platelet aggregation and thromboxane A2 synthesis. Weak antifungal and antituberculosis activity. Useful as lead structure for potent antifungal substances. Group: Biochemicals. Grades: Highly Purified. CAS No. 13640-26-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C12H10N2O, Molecular Weight: 198.2. US Biological Life Sciences. | Worldwide |
| PIP3 Antagonist II, DM-PIT-1, N- ( (2-Hydroxy-5-nitrophenyl) carbamothioyl) -3, 5-dimethylbenzamide, N- ( ( (2-Hydroxy-5-nitrophenyl) amino) thioxomethyl) -3, 5-dimethyl-benzamide, Akt Inhibitor XXII, PDK1 Inhibitor VI) | A cell-permeable benzoylthiourea compound that is shown to compete against PIP3 for binding PH domains of Akt1 (IC50 >31uM), ARNO, GRP1, and P1. Effectively blocks PIP3-dependent cellular PI3K-PDK1-Akt signaling pathway activation in U87MG (25 to 100uM for 3d) and PDGF-induced Akt and GRP membrane translocation in serum-starved SUM159 cells (1h 100uM pretreatment), while being inactive against PDGF-induced Btk translocation or PMA-induced PLC-delta and TAPP1/2 translocations. Although DM-PIT-1 can be administered as a DMSO stock for effective culture treatments, incorporating DM-PIT-1 into PEG-PE mixed micelles enhances its solubility (up to 1mM) and i.v. dosing limit for more effective in vivo administrations (5% vs. 41% of control 4T1 tumor size in mice via 1mg/kg micelles-formulated or 0.4mg/kg free drug daily i.v., respectively). Group: Biochemicals. Grades: Highly Purified. CAS No. 701947-53-7. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?S, Molecular Weight: 345.4. US Biological Life Sciences. | Worldwide |
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