USBiological 4 - Products
Worldwide
Our biochemicals, antibodies, recombinant proteins, cell culture media and molecular biology kits are used in virtually all scientific applications.From affordable research quantities to larger bulk amounts.
| Product | Description | |
|---|---|---|
| Mutolide | Antibiotic. Antibacterial. Phytotoxic. Group: Biochemicals. Alternative Names: (3E,5S,6E,8S,9E,14R)-5,8-Dihydroxy-14-methyloxa-cyclotetradeca-3,6,9-trien-2-one. Grades: Highly Purified. CAS No. 277749-34-5. Pack Sizes: 1mg. Molecular Formula: C??H??O?. US Biological Life Sciences. |  Worldwide |
| m-Vinylaniline | The formation of m-Vinylaniline from the reduction of m-Nitrostyrene containing an easily reducible vinyl-group using hydrazine hydrate as the reducing agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 15411-43-5. Pack Sizes: 50mg, 100mg. Molecular Formula: C8H9N, Molecular Weight: 119.16. US Biological Life Sciences. | Worldwide |
| Myeloperoxidase Inhibitor-II (4-(5-Fluoro-1H-indol-3-yl)butanamide, MPO Inhibitor II) | A 5-fluorotryptamine derivative that inhibits myeloperoxidase/MPO activity (IC50 = 18nM) via direct affinity interaction with enzyme active site heme pyrrole ring D, while exhibiting much reduced affinity toward serotonin reuptake transporter/SERT (Ki = 631nM). Kinetic studies reveal that the inhibitor acts as a good one-electron donor for the intermediate Compound I "Fe(IV)=O.Por +", facilitating the formation of Compound II (Fe(IV)-OH.Por) and thereby preventing the reduction of Compound I directly to the resting state "Fe(IV).Por" via the "halogenation cycle", while, on the other hand, behaves as a poor electron donor for Compound II, thereby preventing the completion of the "peroxidase cycle" by stalling the further reduction of Compound II to the resting state. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??FN?O, Primary Target: Myeloperoxidase. US Biological Life Sciences. | Worldwide |
| Myristoleic Acid | Myristoleic Acid induces apoptosis and necrosis in human prostrate cancer cell LNCaP, and is of a potential for developing an attractive new tool for the treatment of prostrate cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 544-64-9. Pack Sizes: 50mg, 100mg. Molecular Formula: C14H26O2, Molecular Weight: 226.36. US Biological Life Sciences. | Worldwide |
| N1-[2-(1-Piperazinyl)ethyl]-1,2-ethanediamine | N1-[2-(1-Piperazinyl)ethyl]-1,2-ethanediamine is an impurity of Diethylenetriamine (D444255); a compound that is used in biological studies for polyamines inhibition to carbonic anhydrases by anchoring to the zinc-coordinated water molecule. Group: Biochemicals. Grades: Highly Purified. CAS No. 24028-46-4. Pack Sizes: 10mg, 100mg. Molecular Formula: C8H20N4, Molecular Weight: 172.27. US Biological Life Sciences. | Worldwide |
| N(1-(3-Methylbutanamido) N(1-Des(boric Acid)) Bortezomib | N(1-(3-Methylbutanamido) N(1-Des(boric Acid)) Bortezomib is an impurity of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 862894-96-0. Pack Sizes: 10mg, 100mg. Molecular Formula: C19H22N4O3, Molecular Weight: 354.4. US Biological Life Sciences. | Worldwide |
| [N- [ (1S, 2S) -2- (Amino- κ N) -1, 2-diphenylethyl] -4-methyl Benzene sulfonamidato- κ N] chloro [ (1, 2, 3, 4, 5, 6- η ) -1, 3, 5-trimethyl Benzene ] -ruthenium | [N- [ (1S, 2S) -2- (Amino- κ N) -1, 2-diphenylethyl] -4-methyl Benzene sulfonamidato- κ N] chloro [ (1, 2, 3, 4, 5, 6- η ) -1, 3, 5-trimethyl Benzene ] -ruthenium is a chiral catalyst used for transfer hydrogenation of ketones and imines. Group: Biochemicals. Grades: Highly Purified. CAS No. 174813-81-1. Pack Sizes: 250mg, 1g. Molecular Formula: C30H33ClN2O2RuS, Molecular Weight: 622.179999999999. US Biological Life Sciences. | Worldwide |
| N-(2-Indol-3-ylethyl)-succinamic Acid Methyl Ester | N-(2-Indol-3-ylethyl)-succinamic Acid Methyl Ester is an intermediate in the synthesis of Canthin-6-one (C175635), which is used as an anticancer agent compromising cancer cells showing multi-drug resistance. Also used in the synthesis of β-carbolinium compounds as antimalarial agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 92870-51-4. Pack Sizes: 5mg, 10mg. Molecular Formula: C15H18N2O3. US Biological Life Sciences. | Worldwide |
| N- [4- [ [3- (4-Hydroxy-3-methoxyphenyl) -1-oxo-2-propen-1-yl] amino] butyl] carbamic Acid 1,1-Dimethylethyl Ester | N- [4- [ [3- (4-Hydroxy-3-methoxyphenyl) -1-oxo-2-propen-1-yl] amino] butyl] carbamic Acid 1,1-Dimethylethyl Ester is an intermediate in the synthesis of Feruloylputrescine (F308950), an effector of plant root systems, influencing development of nutrient gathering root systems. Group: Biochemicals. Grades: Highly Purified. CAS No. 1208876-43-0. Pack Sizes: 100mg, 250mg. Molecular Formula: C19H28N2O5. US Biological Life Sciences. | Worldwide |
| N-(4-Fluorophenyl)-2-methyl-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide | N-(4-Fluorophenyl)-2-methyl-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide is an impurity of Furanylfentanyl (F864085), which is an opiod analgesic agent and an analog of Fentanyl (F275000). In addition, N-(4-Fluorophenyl)-2-methyl-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide may be a useful compound for developing fentanyl-conjugated vaccines by utilizing a protein-drug conjugate that generates an in vivo immunoantagonist, which can minimize the concentration of a specific drug at the sites of action. Group: Biochemicals. Grades: Highly Purified. CAS No. 244195-32-2. Pack Sizes: 10mg, 50mg. Molecular Formula: C23H29FN2O. US Biological Life Sciences. | Worldwide |
| N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-imino-2-phenazinamine | N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-imino-2-phenazinamine is an analog of Clofazimine (C324300) which is antibacterial. Group: Biochemicals. Grades: Highly Purified. CAS No. 102262-55-5. Pack Sizes: 25mg, 250mg. Molecular Formula: C24H16Cl2N4, Molecular Weight: 431.32. US Biological Life Sciences. | Worldwide |
| N-[(9Z)-1-Oxo-9-octadecenyl]-L-valine | N-[(9Z)-1-Oxo-9-octadecenyl]-L-valine is a transient receptor potential vanilloid type 3 (TRPV3) receptor antagonist. TRPV3 is expressed in skin and involved in skin physiology and pathophysiology, thermo-sensing and nociception. TRPV3 antagonists can be used to develop treatments for inflammatory skin conditions. Group: Biochemicals. Grades: Highly Purified. CAS No. 60374-41-6. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C23H43NO3, Molecular Weight: 381.59. US Biological Life Sciences. | Worldwide |
| NAAG (N-acetyl aspartyl glutamate, Spaglumic Acid, N-Acetyl-Asp-Glu) | NAAG is a neuropeptide and a neurotransmitter that is abundant in the mammalian nervous system. It remains uncertain whether this compound activatesnMDA receptors; however, it is clearly demonstrated to act as a selective agonist of mGluR3, both in vitro and in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 3106-85-2. Pack Sizes: 50mg, 100mg, 250mg, 500mg. Molecular Formula: C11H16N2O8, Molecular Weight: 304.3. US Biological Life Sciences. | Worldwide |
| N-Acetyl-L-cystine | N-Acetyl-L-cystine is an antioxidant, used in the treatment of influenza A virus pandemic (1). N-Acetyl-L-cystine promotes fertilization by reducing disulfide bonds in zona pellucida of mouse (2). Group: Biochemicals. Grades: Highly Purified. CAS No. 25779-79-7. Pack Sizes: 10mg, 25mg. Molecular Formula: C8H14N2O5S2, Molecular Weight: 282.339999999999. US Biological Life Sciences. | Worldwide |
| NAE Inhibitor, MLN4924 | A cell-permeable AMP mimetic that targets the NEDD8-activating E1 enzyme NAE nucleotide-binding site and undergoes a NAE-catalyzed covalent NEDD8 adduct formation, the adduct in turn acts as a tight-binding, ATP-competitive NAE inhibitor (IC50 = 4.7nM), exhibiting much reduced or little potency against UAE/UBA1, UBA6/UBE1L2, SAE, ATG7, adenosine receptors A1/A2A/A2B/A3, or a panel of 12 cellular kinases. Selectively reduces cellular Ubc12-NEDD8, but not Ubc9-SUMO or Ubc10-Ub, thioester formation (ICmax = 90nM in HCT-116 cultures in 24h), resulting in cullin-RING ligases substrates elevation. Shown to inhibit the growth of various cancer cells both in cultures (IC50 from 50nM to 1.03uM) in vitro and in murine xenograft models (30 to 60mg/kg via s.c.) in vivo via apoptosis induction. CAS Number:951950-33-7. Group: Biochemicals. Alternative Names: NEDD8-Activating Enzyme Inhibitor; ( (1S, 2S, 4R) -4- (4- ( (1S) -2, 3-Dihydro-1H-inden-1-ylamino) -7H-pyrrolo[2, 3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl) methyl sulfamate. Grades: Highly Purified. CAS No. 951950-33-7. Pack Sizes: 5mg. Molecular Formula: C21H25N5O4S. US Biological Life Sciences. | Worldwide |
| Nα-Benzoyl-L-arginine-7-amido-4-methylcoumarin Hydrochloride | Nα-Benzoyl-L-arginine-7-amido-4-methylcoumarin Hydrochloride is a sensitive fluorogenic substrate for papain and trypsin. Group: Biochemicals. Grades: Highly Purified. CAS No. 83701-04-6. Pack Sizes: 5mg, 10mg. Molecular Formula: C23H25N5O4 HCl, Molecular Weight: 435.483646. US Biological Life Sciences. | Worldwide |
| Nandrolone 17 β-Undecanoate | Anabolic steroid. Group: Biochemicals. Grades: Highly Purified. CAS No. 862-89-5. Pack Sizes: 25mg, 250mg. Molecular Formula: C29H46O3. US Biological Life Sciences. | Worldwide |
| Naphthomycin B (2-Demethylnaphthomycin A) | Ansamycin antibiotic. Antibacterial and antifungal. Group: Biochemicals. Grades: Highly Purified. CAS No. 86825-88-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Nargenicin A1 | Antibiotic against Gram-positive bacteria, particularly Staphylococcus and Clostridia. More effective against multi-resistant strains (MRSA) than erythromycin and vancomycin. Inhibits cell proliferation and induces HL-60 cell differentiation in combination with 1,25-Dihydroxyvitamin-D3 and ATRA. Displays low cytotoxicity compared to erythromycin and spiramycin. Group: Biochemicals. Alternative Names: Antibiotic 47444; CP 47444; NSC 355066; Nargenicin; Nargenicin A1; Stereoisomer of 3, 4, 6, 7, 8, 8a, 10a, 11, 12, 13, 14, 14a-dodecahydro-14-hydroxy-4-(1-hydroxyethyl)-7-methoxy-1, 3, 13-trimethyl-6-oxo-11, 14b-epoxy-14bH-naphth[2, 1-e]oxecin-12-yl 1H-pyrrole-2-carboxylate; [3R-[1E, 3R*, 4S*(R*), 7S*, 8aS*, 10aR*, 11R*, 12R*, 13R*, 14R*, 14aS*, 14bS*]]-1H-Pyrrole-2-carboxylic acid 3, 4, 6, 7, 8, 8a, 10a, 11, 12, 13, 14, 14a-Decahydro-14-hydroxy-4-(1-hydroxyethyl)-7-methoxy-1, 3, 13-trimethyl-6-oxo-11, 14b-epoxy-14bH-naphth[2, 1-e]oxecin-12-yl Ester; 9-(1H-Pyrrole-2-carboxylate) Nodusmicin. Grades: Highly Purified. CAS No. 70695-02-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??NO?. US Biological Life Sciences. | Worldwide |
| NBD-Binding Peptide II, Cell Permeable (CTP-NBD, NEMO-Binding Domain Binding Peptide II, Cell-Permeable, CTP-NBD) | A cell-permeable cytoplasmic transduction peptide (CTP; YGRRARRRARR) fused to the NEMO binding domain peptide (NBD; TALDWSWLQTE) that acts as a potent inhibitor of TNFa-stimulated NF-kB activity (IC50~50uM in HCT116 cells). Acts by interfering with the formation of active IKK complex and thereby prevents lkBa phosphorylation and its subsequent proteasomal degradation. Also blocks LPS-mediated increase in inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) activities. Colon-targeted capsules containing CTP-NBD are shown to reduce 2, 4, 6-trinitro Benzene sulfonic acid (TNBS)-induced colitis in rodent models (4.5mg/kg/,p.o.) in vivo and diminish activities of myeloperoxidase and several inflammatory mediators. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| N-Boc-beta-alanine-beta-4'-fluorophenyl-n-carboxyanhydride | N-Boc-beta-alanine-beta-4'-fluorophenyl-n-carboxyanhydride. Group: Biochemicals. Grades: Highly Purified. CAS No. 886362-60-3. Pack Sizes: 25mg, 50mg. Molecular Formula: C15H16FNO5, Molecular Weight: 309.29. US Biological Life Sciences. | Worldwide |
| N-Crotonylglycine | N-Crotonylglycine can be synthesized from Glycine Methyl Ester Hydrochloride (G625235), a non-essential amino acid for human development. Group: Biochemicals. Grades: Highly Purified. CAS No. 1026721-15-2. Pack Sizes: 25mg, 50mg. Molecular Formula: C6H9NO3. US Biological Life Sciences. | Worldwide |
| N-Deethoxymethyl Chlorfenapyr | N-Deethoxymethyl Chlorfenapyr is a primary metabolite of Chlorfenapyr (C428500). Chlorfenapyr is a halogenated pyrrole based pro-insecticide. Chlorfenapyr functions by metabolizing into an active insecticide after entering the host. Chlorfenapyr is used primarily as a means of pest control on cotton. Group: Biochemicals. Grades: Highly Purified. CAS No. 122454-29-9. Pack Sizes: 5mg, 10mg. Molecular Formula: C12H5BrClF3N2, Molecular Weight: 349.53. US Biological Life Sciences. | Worldwide |
| N-Despropionyl N-Acetyl Carfentanil Methyl Ester | N-Despropionyl N-Acetyl Carfentanil Methyl Ester is derived from 1-Phenethyl-4-piperidone (P321300), which is an intermediate of Fentanyl (F275000) and Fenspiride (F265000). Group: Biochemicals. Grades: Highly Purified. CAS No. 131821-81-3. Pack Sizes: 5mg, 10mg. Molecular Formula: C23H28N2O3, Molecular Weight: 380.48. US Biological Life Sciences. | Worldwide |
| n-Dodecyl-alpha-D-maltoside (Ultrapure) | Non-ionic detergent. For functional solubilization, purification and crystallography of membrane proteins. For the stabilization and activation of enzymes. Group: Biochemicals. Alternative Names: DDM, n-Dodecyl-alpha-maltoside, Lauryl-alpha-maltoside. Grades: Highly Purified. CAS No. 116183-64-3. Pack Sizes: 1g, 5g. Molecular Formula: C??H??O??. US Biological Life Sciences. | Worldwide |
| n-Dodecyl-beta-D-maltoside (DDM) | Non-ionic detergent. For functional solubilization, purification and crystallography of membrane proteins. For the stabilization and activation of enzymes. Group: Biochemicals. Alternative Names: 1-Dodecyl- β-D-maltoside; DDM; DDM (Detergent); Dodecyl O- β-D-Maltoside; Dodecyl β-D-Maltopyranoside; Dodecyl β-D-Maltoside; Dodecyl β-Maltopyranoside; Dodecyl β-Maltoside; Lauryl Maltoside; Lauryl β-D-Maltopyranoside; Lauryl β-D-Maltoside; Lauryl β-Maltopyranoside; Lauryl β-Maltoside; n-Dodecyl β-D-Maltopyranoside; β-1-n-Dodecyl-D-Maltoside; (2R, 3R, 4S, 5S, 6R) -2- ( ( (2R, 3S, 4R, 5R, 6S) -6- (Dodecyloxy) -4, 5-dihydroxy-2- (hydroxymethyl) tetrahydro-2H-pyran-3-yl) oxy) -6- (hydroxymethyl) tetrahydro-2H-pyran-3, 4, 5-triol. Grades: Highly Purified. CAS No. 69227-93-6. Pack Sizes: 1g, 5g, 10g. Molecular Formula: C24H46O11, Molecular Weight: 510.62. US Biological Life Sciences. | Worldwide |
| Nebivolol Hydrochloride (rel- (aR, aR, 2R, 2S)-a, a-[iminobis (methylene)]bis[6-fluoro-3, 4-dihydro-2H-1-benzopyran-2-methanol] Hydrochloride, b1-Adrenoceptor Antagonist, Nebivolol Hydrochloride, Nebilet, R-65824, Narbivolol) | A competitive, highly selective beta-1-adrenoceptor antagonist (more than 40-fold selective for beta-1 than beta-2; Ki1 and beta-2, respectively). The most beta-1-selective chemical of the beta-blockers tested so far. Used for treatment of essential hypertension and highly cardioselective. Induces mild vasodialation via a nitric oxide- and cGMP-depedent pathways (EC50 = 11.36uM in renal arteries). Group: Biochemicals. Grades: Highly Purified. CAS No. 152520-56-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Nebularine (High Purity) | Nucleoside analog. Cytotoxic. DNA, RNA and protein synthesis inhibitor. Shows anticancer activity. Anti-mycobacterial. Has tuberculostatic activity. Antifungal activity. Antiviral (anti-Herpes). Adenosine deaminase inhibitor. Can be used to analyze structure determinants of DNA that are recognized by DNA repair enzymes, to locate triple helices at G-C sequences or as an universal base, which can bind to all four of the nucleosides of DNA. Group: Biochemicals. Alternative Names: Purine-9-ß-D-ribofuranoside; 9- β-D-Ribofuranosyl-9H-purine; Ribosyl-isopurine; Purinosine; NSC 65423. Grades: Highly Purified. CAS No. 550-33-4. Pack Sizes: 500ug, 1mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| Necrosis Inhibitor, Necrox-2 ([5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(1-methanesulfonyl-piperidin-4-yl)-amine) | A cell-permeable necrosis inhibitor that displays antioxidant property. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1uM NecroX-2 prevented ~50% cell death in H9C2 cells exposed to 400uM t-BuOOH for 2 hours). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Necrosis Inhibitor, Necrox-5 ([5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(tetrahydro-pyran-4-ylmethyl)-amine, Dihydrochloride) | A cell-permeable necrosis inhibitor that displays antioxidant property. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1uM NecroX-5 prevented ~50% cell death in H9C2 cells exposed to 400uM t-BuOOH for 2 hours). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as CCl4 -induced acute liver injury and chronic liver fibrosis in rodent models. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Necrostatin-1 | Competitive indoleamine 2,3-dioxygenase (IDO) inhibitor. Cell permeable, potent and selective necroptosis (a non-apoptotic form of programmed cell death) inhibitor. Showed neuroprotection in a murine model of ischemic brain injury in vivo. Selective and ATP-competitive receptor-interacting protein kinase 1 (RIPK1) inhibitor. Used in inflammatory and degenerative disease models to target RIPK1. Suppresses autophagy and apoptosis in murine brain injury models. Group: Biochemicals. Alternative Names: Nec-1, MTH-Trp, MTH-DL-Tryptophan, Methyl-thiohydantoin DL-tryptophan, 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone. Grades: Highly Purified. CAS No. 4311-88-0. Pack Sizes: 5mg, 25mg. Molecular Formula: C??H??N?OS. US Biological Life Sciences. | Worldwide |
| Nefazodone Hydrochloride (5-HT2A Serotonin Receptor Antagonist, Nefazodone, BMY-13754, MJ-13754-1, Serzone) | A potent 5-HT2A receptor antagonist (Kd = 26nM), with moderate affinity for the alpha1-adrenergic receptor (Kd = 48nM) and 5-HT1A receptor (Kd = 80nM). Originally developed as a clinical antidepressant but discontinued in 2004, nefazodone (Serzone) still remains a specific inhibitor of certain serotonergic pathways. Nefazodone also has been reported to induce mitochondrial dysfunction. Group: Biochemicals. Grades: Highly Purified. CAS No. 82752-99-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Nef Hck Activation Inhibitor, B9 (Nef Dimerization Blocker, (E)-4-((3-Chlorophenyl)diazenyl)-5-hydroxy-3-(4-nitrophenyl)-1H-pyrazole-1-carbothioamide) | A cell-permeable diphenylpyrazolo compound that disrupts HIV accessary protein Nef dimerization (IC50 = 3uM in HEK293T cells) and prevents Nef-mediated Src family kinase Hck activation (IC50 = 2.8uM) without directly affecting the catalytic activity of c-Src, Hck, Lck, or Lyn. Shown to suppress HIV and SIV viral replication (IC50/strain/culture = 1uM/SIV deltaB670/CEM-174 and <0.3uM/HIV-1 NL4-3/CEM-T4) and infectivity, being ineffective against the replication of Nef-defective HIV-1 mutant. Molecular docking and in vitro binding studies reveal a high-affinity B9-targeting site formed at the Nef dimerization interface and a low-affinity binding site on each Nef monomer at the dimer interface periphery. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??ClN?O?S, Primary Target: Nef. US Biological Life Sciences. | Worldwide |
| Neoabietic Acid | Neoabietic Acid is a derivative of Gum Rosin (G855500). It is an abietane-type of diterpene resin acid and reduces the consumption rate, feeding efficiency, and growth rate of the larch sawfly (Pristiphora erichsonii) when applied to their natural food. Group: Biochemicals. Grades: Highly Purified. CAS No. 471-77-2. Pack Sizes: 5mg, 50mg. Molecular Formula: C20H30O2, Molecular Weight: 302.45. US Biological Life Sciences. | Worldwide |
| N-Ethyl-N-(3-sulfobenzyl)sulfanilic Acid | N-Ethyl-N-(3-sulfobenzyl)sulfanilic Acid can be obtained from 3-Sulfobenzaldehyde Sodium Salt (S689165) which can be used for the preparation of a series of novel sulfonamide derivatives, as inhibitors of the enzyme histone deacetylase (HDAC) as a novel approach to the treatment of cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 5363-53-1. Pack Sizes: 5mg, 10mg. Molecular Formula: C15H17NO6S2, Molecular Weight: 371.43. US Biological Life Sciences. | Worldwide |
| Neuronal Differentiation Inducer (Isobavachin, 7-hydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one) | A cell-permeable, 8-prenyl flavone that is shown to induce differentiation of mouse embryonic stem (ES) cells into neuronal cells and astrocytes, at 100nM. It is shown to elicit the down-regulation of p38 and JNK phosphorylation, and the up-regulation of ERK phosphorylation. Co-treatment with GGTI-298 (1000nM), a Geranyl geranyl transferase I Inhibitor selectively abolishes the IBA- but not Retinoic Acid-induced neuronal differentiation, which suggests that the differentiation inducing effect may involve protein prenylation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Neuronal Differentiation Inducer IV (N-Hydroxy-2-oxo-3-(3-phenylpropyl)-1,2-dihydroquinoxaline-6-carboxamide, 2-Oxo-3-(3-phenyl-propyl)-1,2-dihydro-quinoxaline-6-carboxylic Acid Hydroxyamide) | A cell-permeable quinoxaline compound that is shown to induce neuronal differentiation in PC12 and rat MSC (mesenchymal stem cell) cultures with high efficiency (>95%; 20uM for 48h) as determined by Nissl staining, expressions of neuronal markers and genes (B-III tubulin, NSE, Chrna2, Chrnb2, Chrm4, Foxo2, Sizn 1), as well as by whole-cell electrophysiology measurements, without any concomitant astroglial differentiation induction as indicated by the absence of GFAP (glial fibrillary acidic protein) expression. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Neuroprotectant, OBA-09 (2- (2-Oxopropanoyloxy) Benzoic Acid) | A brain-permeable ester of pyruvate and salicylic acid that exhibits anti-oxidative and anti-excitotoxic properties. Following its uptake by the brain tissue, it releases pyruvate and salicylic acid via ester hydrolysis (t1/2 of 43 min in serum). Exerts strong neuroprotective effects in the post-ischemic brain and significantly reduces infarct volume (27% and 65% reduction in 6 and 12 hours following i.v. administration of 10mg/kg in a rat model). Also, blocks Zn2+-induced neuronal cell death. Its neuroprotective effects are attributed to its ability to prevent NAD- and ATP-depletion in post-ischemic brain and suppression of NF-kB activity by reducing IkB-a degradation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Nexturastat A (4-((1-butyl-3-phenylureido)methyl)-N-hydroxybenzamide) | Nexturastat A is an aryl urea derivative that acts as a potent and highly selective inhibitor of histone deacetylase 6 (HDAC6) (IC50 = 5.02 ± 0.60nm). Displays 600-, 1380-, 1330-, 1870-, -2330, -888, -190, -1340, -1510, and -1020-fold selectivities over HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC7, HDAC8, HDAC9, HDAC10, and HDAC11, respectively. Nexturastat A also displays antiproliferative effects against melanoma cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| NFAT Inhibitor, MCV1 (MPB-HPVIVIT, Maleimido-conjugated HPVIVIT, Maleimido-conjugated VIVIT 1) | A cell-permeable, synthetic maleimido-conjugated VIVIT motif peptide (HPVIVIT) that acts as a potent bipartite inhibitor of Nuclear factor of activated T-cells (NFAT) (IC50=62nM). Blocks NFAT-calcineurin interaction by targeting two separate calcineurin docking motifs. Completely blocks NFAT dephosphorylation at 1mM. Determined to be more potent that Cyclosporine A and VIVIT peptide (MAGPHPVIVITGPHEE) in blocking NFAT activity. Also shown to blocks NFAT-mediated T-cell activation and vascular smooth muscle cell proliferation, thereby reducing neoimtima (new thickening of arterial wall) formation in mouse models of restenosis (repeat blocking of blood vessels). The biological half life of MCV1 has been estimated to be about 36 hours in COS-1 cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C??H??N??O??. US Biological Life Sciences. | Worldwide |
| NF-kB Activation Inhibitor VIII, EVP4593 (SOC Inhibitor, Neuronal Store-Operated Calcium Entry Inhibitor, N4- (4-phenoxyphenethyl) quinazoline-4, 6-diamine, TRPC1 Inhibitor) | A cell-permeable quinazoline derivative that blocks PMA/PHA-induced NF-kB activation in Jurkat cells (IC50=11nM), but has no effect on PKC kinase, and exhibits an anti-inflammatory effect on carrageenin-induced paw edema in rats (1mg/kg, i.p.). In addition, it is shown to inhibit the store-operated calcium entry (SOC) pathway possibly by targeting TRPC1 containing heteromeric channels in Huntington Disease (HD) neurons (SK-N-SH cells transfected with mutant Huntingtin Htt-138Q) at 300nM. It displays neuroprotective effects in YAC128 MSN mice neurons from glutamate toxicity dose-dependently from 30nM to 3uM, which is consistent with TRPC1 knocown effects, and attenuates the progressive decline in the climbing speed of the HD Drosophila, dose-dependently from 100uM to 400uM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| NG 012 (BK223A, 15G256 alpha, 32-Hydroxy-orbuticin) | Antibiotic. Antifungal. Nerve growth factor (NGF) potentiator. Group: Biochemicals. Grades: Highly Purified. CAS No. 141731-76-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C32H38O15, Molecular Weight: 662.7. US Biological Life Sciences. | Worldwide |
| Niclosamide-13C6 | Isotope labelled Niclosamide is used as an anthelmintic drug (Cestodes). Group: Biochemicals. Grades: Highly Purified. CAS No. 1325559-12-3. Pack Sizes: 500ug, 5mg. Molecular Formula: C713C6H8Cl2N2O4, Molecular Weight: 333.08. US Biological Life Sciences. | Worldwide |
| Nitric Acid (65%) | Nitric Acid is a highly corrosive mineral acid used in organic nitration reactions. Also used in fertilizers. Group: Biochemicals. Grades: Highly Purified. CAS No. 7697-37-2. Pack Sizes: 25ml, 100ml. Molecular Formula: HNO3, Molecular Weight: 63.01. US Biological Life Sciences. | Worldwide |
| Nitrotyrosine, Positive Control (NT, 3-Nitro-L-Tyrosine, 3-Nitrotyrosine) | Nitrotyrosine, Positive Control (NT, 3-Nitro-L-Tyrosine, 3-Nitrotyrosine). Group: Molecular Biology. Pack Sizes: 15ul. US Biological Life Sciences. | Worldwide |
| NMDA Antagonist XI, N1-dansyl-spermine (NMDA Channel Blocker, N1-dansyl-spermine, N1-DnsSpm) | An N-sulfonyl-polyamine that acts as a potent and more specific antagonist ofnMDA receptors expressed in Xenopus oocytes (IC50 = 310, 340nM in NR1/NR2A and NR1/NR2B, respectively). The inhibition appears to be voltage-dependent and is non-competitive with respect to glutamate and glycine. Exhibits about 50-fold greater selectivity over NR1/NR2C and NR1/NR2D receptors (IC50 = 16 and 13uM, respectively). Also shown to block c-AMP-dependent, calmodulin-activated phosphodiesterase (IC50 = 58uM) and diminishes the induction of ornithine decarboxylase. At higher concentration (100uM) it is shown to reduce spontaneous epileptiform activity in mouse cortical slices. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| NMDAR2C/2D Inhibitor, DQP-1105 (DQP-1105, NMDA Antagonist IV) | A dihydroquinilone-pyrazoline NMDA antagonist, which is selective for NMDA receptors that are comprised of recombinant subunits GluN1/GluN2C (IC50 = 5.4uM) and GluN1/GluN2D (2.2uM) over GluN1/GluN2B (206uM) and GluN1/ClucN2A (undetectable) in Xenopus oocytes. Similar selectivity is observed in whole-cell HEK patch-clamp assays with IC50 values for GluN2C and GluN2D that are at least 50-fold lower than those for recombinant GluN2A, GluN2B, GluA1, or GluK2-containing receptors. It inhibits NMDA by blocking a conformational change necessary for channel opening and is non-competitive with co-agonists, glutamate and glycine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| NMDA Receptor NR2BCT(1292-1304)-TAT (Tat-NR2BCT, H-KKNRNKLRRQHSY-Ahx-YGRKKRRQRRR-NH2) | A 13-mer NMDA receptor 2B (NR2B) subunit carboxy terminal (1292-1304) derived peptide that specifically binds DAPK1 (death-associated protein kinase 1) in a reversible manner and antagonizes the activated DAPK1-NR2B interaction and the potentiation of nMDAR function with no effect on either the catalytic activity of DAPK1 or the nMDA receptor physiology. Blocks Ca2+ influx through extrasynaptic nMDA receptors (at 50uM) and the blood-brain-barrier permeable version, namely NR2BCT(1292-1304) attached to TAT(47-57) via a spacer (6-aminohexanoic acid) protects cortical neurons from nMDA receptor-mediated insults and reduces brain infarction and improve neurological functions in mice (10mg/kg, i.v.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C???H???N??O??, Molecular Weight: 3382. US Biological Life Sciences. | Worldwide |
| N-Methylurea | N-Methylurea is used as a reagent in the synthesis of bis (aryl) (hydroxyalkyl) (methyl)glycoluril derivatives and is a potential byproduct of caffeine. Group: Biochemicals. Grades: Highly Purified. CAS No. 598-50-5. Pack Sizes: 5g, 25 g. Molecular Formula: C2H6N2O. US Biological Life Sciences. | Worldwide |
| N,N-Dimethyl-o-toluidine | N,N-Dimethyl-o-toluidine is a building block that has been used as an epoxy catalyst for curing Epon 828. (CAS 25068-38-6). Group: Biochemicals. Grades: Highly Purified. CAS No. 609-72-3. Pack Sizes: 25g, 50 g. Molecular Formula: C9H13N. US Biological Life Sciences. | Worldwide |
| N,N-Dipropyl-1H-indole-3-ethanamine | N,N-Dipropyl-1H-indole-3-ethanamine is a tryptamine designer drug used in toxicology studies which was one of the findings in an analysis of street drugs in seized material without primary reference standards. Group: Biochemicals. Grades: Highly Purified. CAS No. 61-52-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C16H24N2, Molecular Weight: 244.38. US Biological Life Sciences. | Worldwide |
| nNOS - PSD-95 Interaction Inhibitor, ZL006 (5-(3,5-dichloro-2-hydroxybenzylamino)-2-hydroxybenzoic Acid) | A cell-permeable and blood-brain barrier-permeant aminosalicylic acid compound that selectively disrupts nNOS and PSD-95 interaction uponnMDAR activation both in primary murine cortical neurons (0.8- and 2.8-fold increase from basal level with or without 30min 10uM ZL006 pretreatment) in vitro and in mice (0.4- and 1.9-fold increase from basal level with or without inhibitor pretreatment 15min before ischemia; 1.5mg/kg i.v.) in vivo without affecting nNOS activity or non-nNOS-mediated nMDAR EPSCs (excitatory postsynaptic currents). Effectively reduce ischemia-caused brain tissue damage in both mice and rats when applied 1h after blood reperfusion following ishemia (60% and 50% reduction of infarction, respectively; 1.5mg/kg i.v.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Nodularin (in ethanol) | Nodularin is a hepatotoxic monocylic pentapeptide produced by cyanobacterium Nodularia spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026nm, respectively. It inhibits PP2B only at higher concentrations (IC50=1.8uM). Group: Biochemicals. Alternative Names: Cyclo[(2S, 3S, 4E, 6E, 8S, 9S)-3-amino-9-methoxy-2, 6, 8-trimethyl-10-phenyl-4, 6-decadienoyl-D-γ-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D- β-aspartyl-L-arginyl]; Cyclo[(Z)-2,3-didehydro-N-methyl-2-aminobutanoyl-erythro-3-methyl-D- β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyl-3-aminodecanoyl-D-γ-glutamyl]; 1, 4, 8, 11, 15-Pentaazacyclononadecan e Cyclic Peptide Deriv.; Nodularin R. Grades: Highly Purified. CAS No. 118399-22-7. Pack Sizes: 100ug. Molecular Formula: C??H??N?O??, Molecular Weight: 824.96. US Biological Life Sciences. | Worldwide |
| Nootkatone | Nootkatone is an effective repellent/insecticide against mosquitos, and may repel bed bugs, head lice and other insects. Nootkatone in spray form has been shown as an effective repellent/insecticide against deer ticks and lone star ticks. Group: Biochemicals. Grades: Highly Purified. CAS No. 4674-50-4. Pack Sizes: 250mg, 1 g. Molecular Formula: C15H22O. US Biological Life Sciences. | Worldwide |
| nor-Binaltorphimine Dihydrochloride (Norbinaltorphimine, nor-BNI, kappa Opioid Receptor Antagonist, nor-Binaltorphimine) | A potent antagonist highly selective for kappa opioid receptor with no effect on mu- or delta- opioid receptors. Widely used in studies related to pain, addition, anxiety, depression, and sleep. Group: Biochemicals. Grades: Highly Purified. CAS No. 105618-26-6. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?·2HCl. US Biological Life Sciences. | Worldwide |
| Norfentanyl | Norfentanyl (Fentanyl EP Impurity B(USP Impurity C)) is a metabolite of fentanyl. Feentanyl is a μ-opioid agonist used in the treatment of acute, severe, or chronic pain. it can be used as an adjunct to general anesthetics and it is also a potent or narcotic analgesic. Group: Biochemicals. Grades: Highly Purified. CAS No. 1609-66-1. Pack Sizes: 5mg, 50mg. Molecular Formula: C14H20N2O. US Biological Life Sciences. | Worldwide |
| Nourseothricin, Sterile Solution, 100mg/ml (NTC, Nurseotricin, Nourseotricin, clonNAT, Streptothricin Sulfate) | A group of antibiotic substances produced by Streptomyces variants. They are composed of an aminosugar and different polypeptide chains and may have broad spectrum antimicrobial and some antiviral properties. Streptothricin antibiotic Nourseothricin (NTC) is used for a broad spectrum of viruses, bacteria and other unicellular or complex organisms. Preferred selection antibiotic for genetically modified Gram-positive and Gram-negative bacteria, yeast, filamentous fungi, protozoa, plants and many more. Selection of recombinant strains is based on inactivation of NTC by monoacetylation of ß-amino group of the ß-lysine by Nouresothricin N-acetyltransferase the product of the sat1 gene. Group: Biochemicals. Alternative Names: Nourseothricin Sulfate. Grades: Purified. CAS No. 96736-11-7. Pack Sizes: 1ml, 5ml, 10ml. US Biological Life Sciences. | Worldwide |
| Novel Inducer of Death-1, NID-1 ((E)-N-(2-ethylphenyl)-3-(5-nitrothiophen-2-yl)acrylamide) | A cell-permeable, nitrothiophenyl propenamide compound that induces active, energy-dependent, and rapid non-apoptotic cell death (EC50 = 1.65uM) in several transformed (DRD, RKO, H1299) and non-transformed (BJeH) human cells, in a variety of cancer cell lines, and in mouse embryonic fibroblasts. The cell death appears to be non-necrotic, non-oxidative and is independent of DNA damage or cell proliferation. NID-1 induced cell death, although distinct from macroautophagy, does show PI 3-kinase suppression, ATG5-dependence, p62 degradation, and higher LC3 levels. Also, NID-1-induced death is independent of caspases, Bax and Bak and requires lysosomal activity and cytosolic vacuolization. Rescues mutant-huntingtin-induced cell death in a cell-based model of Huntingtons disease. Shown to increase cathepsin L levels, but does not affect cathepsins B, C, and H. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
| NOX Inhibitor VII, Thr101 (NADPH Oxidase Inhibitor VII, 6-Fluoro-2-o-tolylbenzo [d]isothiazol-3 (2H) -one, 6-Fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3(2H)-one) | A cell-permeable, selenium-to-sulfur substituted Ebselen derivative that exhibits similar NOX2 inhibitory activity as Ebselen by blocking p22phox c-terminal PRD (proline-rich domain) and p47phoxbis-SH3 interaction. Although less potent than Ebselen in cell-free p22phox PRD-p47phoxbis-SH3 binding (IC50 = 4 vs. 0.3uM) and NOX2 activity (IC50 = 4 vs. 0.6uM) assays, Thr101 is more potent and NOX2-selective than Ebselen in cell-based assays (Thr101 IC50 /Ebselen IC50 = 0.3/0.5, 3/0.15, 8/no inhibition, 8/0.7uM, respectively, against NOX2, NOX1, NOX4, and NOX5) and exhibits no glutathione peroxidase activity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??FNOS, Primary Target: Blocks p22phox c-terminal PRD (proline-rich domain) and p47phox bis-SH3 interaction. US Biological Life Sciences. | Worldwide |
| Nrf2 Activator II, AI-1 (Ethyl-4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate) | A cell-permeable chloro-quinolinone compound that selectively and covalently modifies Kelch-like ECH-associated protein 1 (Keap1)-Cys151 and represses Keap1 function and reduces Nrf2 (Nuclear factor E2-related factor 2)-Keap1 interaction. Shown to stabilize Nrf2 by inhibiting the Keap1-driven ubiquitination of Nrf2 and thereby activating the Nrf2-ARE (antioxidant response element) pathway (EC50 = 2.7uM in neuroblastoma IMR-32 cells). Offers protection against H2O2 induced oxidative stress, but unlike tert-butylhydroquinone AI-1 does not act as a free radical scavenger. Its anti-oxidant effects are mediated via Nrf2 induced antioxidant response. Does not affect mutant ARE where GC are substituted with AT within the core ARE sequence. Group: Biochemicals. Grades: Highly Purified. CAS No. 75483-04-4. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Nrf2 Activator III, TAT-14 Peptide, H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH | A 14-mer peptide (LQLDEETGEFLPIQ) conjugated to cell-penetrating trans-activating transcriptional activator (TAT) sequence (YGRKKRRQRRRLQ) that targets the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) binding site on Kelch-like ECH-associated protein 1 (Keap1). Competitively disrupts Nrf2-Keap1 interaction and stabilizes cytosolic Nrf2, and promotes its nuclear translocation and binding to the antioxidant response element (ARE). Exhibits anti-inflammatory properties and increases heme-oxygenase-1 gene expression (~75uM). Also shown to suppress LPS-induced TNF-a secretion in THP-1 monocytes (~ 37.5uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 1362661-34-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| NS1738 (1- (5-chloro-2-hydroxyphenyl) -3- (2-chloro-5- (trifluoromethyl) phenyl) urea, a7 nAChR Positive Allosteric Modulator, NS1738, NS 1738, NS-1738) | A biarylurea derivative that acts as a selective positive allosteric modulator selective for alpha7 nicotinic acetylcholine receptors (alpha7 nAChR) without substantial activity for alpha4beta2, alpha3beta3 and alpha1-containing receptors. Exhibits cognitive enhancing effects in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 501684-93-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| NS8593 ((R)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine) | An aminobenzimidazole derivative that selectively and reversibly blocks small conductance Ca2+-activated K+ channels (SK1-3; =420nM, 600nM, and 730nM for SK1, SK2, SK3, respectively) in a Ca2+-dependent manner. It mediates channel gating by interacting with gating structures deep within the inner pore vestibule where Ser507 and Ala532 are deemed to be important for inhibition. Interacts at a site that is distinct from the apamin binding site in SK channels. Can access high-affinity binding sites from both the inside and outside of the cell membrane. Does not affect QT intervals, but prolongs the atrial effective refractive period and prevents acetylcholine-induced atrial fibrillations in ex vivo and in vivo models. Also shown to reversibly block TRPM7 channel (IC50=1.6mM) in smooth muscle cells, primary podocytes, HEK293 cells expressing TRPM7, and ventricular myocytes in a Mg2+-dependent manner and blocks the motility of cells in culture. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Nullscript (4-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-N-hydroxybutanamide) | A negative control compound for the histone deacetylase (HDAC) inhibitor Scriptaid. Group: Biochemicals. Grades: Highly Purified. CAS No. 300816-11-9. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Nur77 LBD Antagonist, TMPA (AMPK Signaling Activator XII, Liver Kinase B Activator, LKB1 Activator, MARK Signaling Activator, STK11 Activator, TR3 LBD Antagonist, Ethyl-2- (2, 3, 4-trimethoxy-6- (1-octanoyl) phenyl) acetate) | A cell-permeable phenylacetate compound that blocks Nur77 (TR3) LKB1 nuclear-sequestering function by antagonizing against Nur77-LKB1 interaction via direct binding at the LKB1 LBD/ligand binding domain (Kd = 0.14 against 5uM LKB1 binding to 5uM full-length Nur77). Shown to induce LKB1 Ser428 phosphorylation (10 & 20uM for 6h) and LKB1 nuclear-to-cytosol translocation in hepatic LO2 cells, resulting in enhanced phosphorylations of LKB1 cytosolic effectors AMPKalpha and MARK1/2/3 without affecting Nur77 transactivation activity. Daily i.p. dosing (50mg/kg) is shown to increase liver LKB1 Ser428/AMPKalpha Thr172 phosphorylations in diabetic db/db mice in vivo, effectively improving animal glucose tolerance. Also reported to lower fasting blood glucose level in STZ-treated, high fat diet-fed type II diabetic mice. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| NVP-AAM077 Tetrasodium Hydrate (NVP-AAM077, [[[ (1S) -1- (4-Bromophenyl) ethyl]amino] (1, 2, 3, 4-tetrahydro-2, 3-dioxo-5-quinoxalinyl) methyl] Phosphonic Acid Tetrasodium Hydrate, PEAQX Tetrasodium Hydrate, NMDA Antagonist VII) | A potent antagonist for NMDA receptors. Modestly higher selectivity for the NR2A than for the NR2B containing NMDA receptors (IC50 = 0.015 and 0.078uM) but insufficient to discriminate between NR2A and NR2B-containing NMDA receptors. Widely used for researches in synaptic plastic, learning and memory, and epilepsy. Group: Biochemicals. Grades: Highly Purified. CAS No. 459836-30-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Obscurolide A1 | Weak phosphodiesterase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 144397-99-9. Pack Sizes: 1mg. Molecular Formula: C15H17NO5. US Biological Life Sciences. | Worldwide |
| Octadecylamine | Octadecylamine is used in biological studies for the formation of ion pairing as alternative to improve encapsulation and stability and to reduce skin irritation of retinoic acid loaded in solid lipid nanoparticles. Group: Biochemicals. Grades: Highly Purified. CAS No. 124-30-1. Pack Sizes: 5g, 25g. Molecular Formula: C18H39N, Molecular Weight: 269.51. US Biological Life Sciences. | Worldwide |
| Octyl Salicylate | Octyl salicylate is a fragrance ingredient that blocks UVB rays. Group: Biochemicals. Grades: Highly Purified. CAS No. 6969-49-9. Pack Sizes: 1g, 2.5g. Molecular Formula: C15H22O3, Molecular Weight: 250.33. US Biological Life Sciences. | Worldwide |
| O-Desmethyl Thebainone | O-Desmethyl Thebainone is an analogue of Thebainone (T342500). Thebainone is a metabolite of Thebaine (T342450) which is an opiate. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 50mg. Molecular Formula: C17H20BrNO3. US Biological Life Sciences. | Worldwide |
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