USBiological 4 - Products
Worldwide
Our biochemicals, antibodies, recombinant proteins, cell culture media and molecular biology kits are used in virtually all scientific applications.From affordable research quantities to larger bulk amounts.
| Product | Description | |
|---|---|---|
| Gap Junction Enhancer, PQ7 | A cell-permeable quinoline derived compound with low toxicity that enhances gap junctional activity by about 16-fold (at ~500nM) in T47D breast cancer cells and thereby potentiates the effect of chemotherapeutic agents. Blocks T47D cell colony formation (IC50 = 100nM) and reduce the growth of T47D xenograft tumors by 100% in Nu/Nu mice. Increases caspase-3, - 8, and -9 expression by 1.6, 2.8, and 3.8-fold, respectively to induce apoptotic cell death. Can work synergistically with cisplatin to reduce or totally eliminate tumor growth. Increases the expression of connexins 26, 32, and 43 to allow more efficient trafficking of cisplatin. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N2O?, Primary Target IC50: 100nM. US Biological Life Sciences. |  Worldwide |
| Gardiquimod | Immune response modifier. Antiviral and antitumor compound. Selective ligand for human or mouse Toll-like receptor 7 (TLR7). Induces the activation of NF-kappaB in HEK 293 cells expressing TLR7 at 0.1ug/ml. 10 times more active than Imiquimod. At high concentrations (3ug/ml) slightly activates TLR8. Shows adjuvant activity to increase the effectiveness of vaccines. Group: Biochemicals. Alternative Names: 1- (4-Amino-2-ethylamino methyl imidazo [4, 5-c] quinolin-1-yl) -2- methyl propan-2-ol, 4-Amino-2-[(ethylamino)methyl]-?,?-dimethyl-1H-Imidazo[4,5-c]quinoline-1-ethanol. Grades: Highly Purified. CAS No. 1020412-43-4. Pack Sizes: 5mg, 25mg. Molecular Formula: C??H??N?O. US Biological Life Sciences. | Worldwide |
| GBR 12909 Dihydrochloride | A potent inhibitor of dopamine active transporter (DAT, Ki=1nM, IC50=40 and 51nM) with >100 fold selectivity over noradrenalin and 5-HT re-uptake transporter. Shown to produce behavioral profile in mice for bipolar mania disease model and ADHD disease models. Group: Biochemicals. Alternative Names: 1-[2-[Bis (4-fluorophenyl) methoxy]ethyl]-4- (3-phenylpropyl) -piperazine Dihydrochloride (9CI); GBR 12909; I 893; Vanoxerine Dihydrochloride; 1-[2-[Bis (4-fluorophenyl) methoxy]ethyl]-4- (3-phenylpropyl) -piperazine Hydrochloride (1:2). Grades: Highly Purified. CAS No. 67469-78-7. Pack Sizes: 10mg, 25mg, 50mg. Molecular Formula: C??H??F?N?O 2HCl, Molecular Weight: 450.56 (anhydrous). US Biological Life Sciences. | Worldwide |
| Genistein | Cell-permeable, reversible, substrate competitive tyrosine kinase inhibitor (including EGFR phosphorylation), implicated in almost all cell growth and proliferation signal cascades. Inhibitor of mammalian DNA topoisomerase II. Anticancer agent, inducing cell cycle arrest and apoptosis. Antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis. Binds estrogen receptor beta. Can increase the rate of growth of some ER expressing breast cancers. Potent alpha-glucosidase inhibitor. Anthelmintic. Anti-diabetic. Activates nuclear receptors, oestrogen receptors and peroxisome proliferator-activated receptors (all PPAR isoforms) and it inhibits various enzyme activities. Inhibitor of GLUT4-mediated glucose uptake in 3T3-L1 adipocytes. Stimulator of autophagy vacuolization. Antioxidant. TRAIL sensitizer. Acts as an agonist at the GPR30 receptor. DNA methyltransferase inhibitor. Genistein exhibits synergistic antibacterial effects on MRSA. Group: Biochemicals. Alternative Names: NSC 36586; Baichanin A; Differenol A; 4',5,7-Trihydroxyisoflavone; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. Grades: Highly Purified. CAS No. 446-72-0. Pack Sizes: 10mg, 50mg, 250mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
| Genomic DNA Control, Human, Methylated BioGenomics | Methylated human jurkat cell genomic DNA was generated by treating genomic DNA with. Group: Biologicals. Pack Sizes: 5ug. US Biological Life Sciences. | Worldwide |
| Genomic DNA, Human Adult Normal, Tissue, Adipose, Single donor BioGenomics | DNA is isolated by proprietary modified guanidine thiocyanate techniques. The DNA is dissolved in 1xTE (10mM Tris pH 8.0, 1mM EDTA) buffer. Group: Biologicals. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Genomic DNA, Human Adult Normal, Tissue, Colon, FFPE BioGenomics | FFPE DNAs are isolated from Formalin Fixed Paraffin Embedded materials. Group: Biologicals. Pack Sizes: 2ug. US Biological Life Sciences. | Worldwide |
| Genomic DNA, Human Adult Normal, Tissue, Colon, Single donor BioGenomics | DNA is isolated by proprietary modified guanidine thiocyanate techniques. The DNA is dissolved in 1xTE (10mM Tris pH 8.0, 1mM EDTA) buffer. Group: Biologicals. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Genomic DNA, Human Adult Normal, Tissue, Heart, Pericardium, Single donor BioGenomics | DNA is isolated by proprietary modified guanidine thiocyanate techniques. The DNA is dissolved in 1xTE (10mM Tris pH 8.0, 1mM EDTA) buffer. Group: Biologicals. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Genomic DNA, Human Adult Normal, Tissue, Kidney, Single donor BioGenomics | DNA is isolated by proprietary modified guanidine thiocyanate techniques. The DNA is dissolved in 1xTE (10mM Tris pH 8.0, 1mM EDTA) buffer. Group: Biologicals. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Genomic DNA, Human Adult Normal, Tissue, Liver, FFPE BioGenomics | FFPE DNAs are isolated from Formalin Fixed Paraffin Embedded materials. Group: Biologicals. Pack Sizes: 2ug. US Biological Life Sciences. | Worldwide |
| Genomic DNA, Human Adult Normal, Tissue, Lung, FFPE BioGenomics | FFPE DNAs are isolated from Formalin Fixed Paraffin Embedded materials. Group: Biologicals. Pack Sizes: 2ug. US Biological Life Sciences. | Worldwide |
| Genomic DNA, Human Adult Normal, Tissue, Pancreas, Single donor BioGenomics | DNA is isolated by proprietary modified guanidine thiocyanate techniques. The DNA is dissolved in 1xTE (10mM Tris pH 8.0, 1mM EDTA) buffer. Group: Biologicals. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Genomic DNA, Human Adult Normal, Tissue, Stomach, Single donor BioGenomics | DNA is isolated by proprietary modified guanidine thiocyanate techniques. The DNA is dissolved in 1xTE (10mM Tris pH 8.0, 1mM EDTA) buffer. Group: Biologicals. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Genomic DNA, Human Tumor, Tissue, Breast, FFPE BioGenomics | FFPE DNAs are isolated from Formalin Fixed Paraffin Embedded materials. Group: Biologicals. Pack Sizes: 2ug. US Biological Life Sciences. | Worldwide |
| Genomic DNA, Human Tumor, Tissue, Colon, FFPE BioGenomics | FFPE DNAs are isolated from Formalin Fixed Paraffin Embedded materials. Group: Biologicals. Pack Sizes: 2ug. US Biological Life Sciences. | Worldwide |
| Genomic DNA, Human Tumor, Tissue, Lung, FFPE BioGenomics | FFPE DNAs are isolated from Formalin Fixed Paraffin Embedded materials. Group: Biologicals. Pack Sizes: 2ug. US Biological Life Sciences. | Worldwide |
| Genomic DNA, Human Tumor, Tissue, Pancreas, FFPE BioGenomics | FFPE DNAs are isolated from Formalin Fixed Paraffin Embedded materials. Group: Biologicals. Pack Sizes: 2ug. US Biological Life Sciences. | Worldwide |
| Genomic DNA, Human Tumor, Tissue, Stomach, FFPE BioGenomics | FFPE DNAs are isolated from Formalin Fixed Paraffin Embedded materials. Group: Biologicals. Pack Sizes: 2ug. US Biological Life Sciences. | Worldwide |
| Genomic DNA, Human Tumor, Tissue, Uterus, FFPE BioGenomics | FFPE DNAs are isolated from Formalin Fixed Paraffin Embedded materials. Group: Biologicals. Pack Sizes: 2ug. US Biological Life Sciences. | Worldwide |
| Genomic DNA, Plant Normal, Tissue, Arabidopsis BioGenomics | DNA is isolated by proprietary modified guanidine thiocyanate techniques. Group: Biologicals. Pack Sizes: 5ug. US Biological Life Sciences. | Worldwide |
| Geodin | Plasminogen activator inhibitor (PAI-1). Glucose uptake stimulator. Group: Biochemicals. Alternative Names: (1'R)-5,7-dichloro-4-hydroxy-6'-methoxy-6-methyl-3,4'-dioxo-spiro[benzofuran-2(3H),1'-[2,5]cyclohexadiene]-2'-carboxylic acid, methyl ester, Erdin (+)-form methyl ester; Estin. Grades: Highly Purified. CAS No. 427-63-4. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??Cl?O?. US Biological Life Sciences. | Worldwide |
| Geranylgeranyl Pyrophosphate | Geranylgeranyl Pyrophosphate is a non-peptide antigens recognized by human γδ T cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 6699-20-3. Pack Sizes: 1mg, 10mg. Molecular Formula: C20H36O7P2, Molecular Weight: 450.44. US Biological Life Sciences. | Worldwide |
| Ghrelin Receptor Antagonist, JMV 2959 | A 1, 2, 4-triazole derived compound that acts as a potent ghrelin receptor (GHS-R1a) antagonist (IC50 = 32nM in a binding assay, dissociation constant Kb = 19nM). Shown to reduce hexarelin-induced food intake [hexarelin (80ug/kg, cumulative food intake (g of food/100g of body weight) at 6h by acute administration (sc) of JMV 2959 (160ug/kg)] in rats without affecting the basal food intake. Also suppresses ghrelin and fasting-induced food intake at the level of the central nervous system. Reported to suppress genes up-regulated by ghrelin. Does not affect intracellular Ca2+ mobilization. Group: Biochemicals. Alternative Names: (R)-N-(2-(1H-indol-3-yl)-1-(4-(4-methoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)ethyl)-2-aminoacetamide Hydrochloride, GHSR1a Antagonist, GH Secretagogue Receptor Antagonist, JMV2959, Growth Hormone Secretagogue Receptor Antagonist. Grades: Highly Purified. CAS No. 925238-89-7. Pack Sizes: 10mg. Molecular Formula: C??H??N?O, Molecular Weight: 254.29. US Biological Life Sciences. | Worldwide |
| Gilvocarcin V | Antibiotic. Antitumor compound. Weakly active against Gram-positive bacteria and fungi. Mediates a unique cross-linking reaction between DNA and histone H3 by light. Single strand scission and covalent binding to DNA after photoactivation. Source:Streptomyces sp. Gö 3592. Group: Biochemicals. Alternative Names: 4-(6-Deoxy-α-D-galactofuranosyl)-8-ethenyl-1-hydroxy-10,12-dimethoxy-6H-benzo[d]naphtho[1,2-b]pyran-6-one; Antibiotic 1072B; NSC 338943; NSC 348115. Grades: Highly Purified. CAS No. 77879-90-4. Pack Sizes: 100ug, 250ug, 1mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
| GIRK Activator, ML297 (1-(3,4-Difluorophenyl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea, N-(3,4-Difluorophenyl)-N?-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea, CID 56642816, VU0456810) | A blood-brain barrier-permeable, non-toxic phenyl-pyrazolylurea compound that acts as a direct, potent, fast, and reversible activator of GIRK1 (G-protein activated inward-rectifying K+ channel containing subunit 1) containing channels (EC50 = 162, 914, and 887nM in Thallium influx assay for GIRK1/2, GIRK1/3, and GIRK1/4 expressed in HEK-293 cell lines). Its action does not require the presence of an activated Gi GPCR. Shown to be inactive towards GIRK2, GIRK2/3, Kir2.1, KV7.4 and GABAA, and weakly active against a panel of 61 other receptors, ion channels, enzymes, transporters, and proteins even at higher concentration (~10uM). Exhibits desirable pharmacokinetic properties with good solubility (17.5uM), predicted hepatic clearance (88 ml/min/kg), and Tmax of 640nM and 130nM in plasma and brain, respectively. Shown to reduce locomotor function and seizure frequency in electroshock- and chemically-induced murine epilepsy models (60mg/kg, i.p). Group: Biochemicals. Grades: Highly Purified. CAS No. 1443246-62-5. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O. US Biological Life Sciences. | Worldwide |
| Glucagon-Like Peptide 1 Receptor Agonist | A nonpeptidic quinoxaline compound that acts as a GLP-1R agonist and an allosteric modulator of GLP-1 binding. Shown to induce GLP-1R-mediated cAMP production in BHK plasma membrane preparations (EC50=101nM) and potentiate glucose-dependent insulin release in pancreatic islets derived from wild-type, but not GLP-1R -/-, mice. Unlike GLP-1, its biological activity is not inhibited by orthosteric antagonists such as Exendin. Group: Biochemicals. Alternative Names: 6,7-dichloro-N-(1,1-dimethylethyl)-3-(methylsulfonyl)-, 6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline (DMB); Compound 2; GLP-1R Agonist. Grades: Highly Purified. CAS No. 281209-71-0. Pack Sizes: 5mg. Molecular Formula: C??H??Cl?N?O?S, Molecular Weight: 348.3. US Biological Life Sciences. | Worldwide |
| Glucagon-Like Peptide 1 Receptor Agonist II (4- (3- (benzyloxy) phenyl) -2- (ethylsulfinyl) -6- (trifluoromethyl) pyrimidine, Glucagon-Like Peptide 1 Receptor Agonist II, Compound B) | A pyrimidine small molecule that acts as a GLP-1 allosteric agonist that induces cAMP signaling in HEK293 cells expressing the GLP-1 receptor with EC50 = 0.66uM and 99% efficacy (similar data with rat GLP-1 receptor), does not compete with radiolabelled GLP-1 in receptor binding assays, and is not active in cells expressing the GLP-2, GIP, PTH, or glucagon receptors. In rodent islets, insulin secretion increases in a dose-dependent and glucose-dependent manner, either alone or in an additive fashion when combined with the endogenous GLP-1 peptide. In vivo, this molecule exhibits insulinotropic effects when dosed at 10mg/kg in SD rats undergoing an IVGTT and a hyperglycemic clamp. It is also shown to increase insulin secretion in perifusion assays involving normal and diabetic human islets ex vivo, at concentrations between 1 and 10uM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Gluconic Acid(contains Gluconolactone)(45-50% in Water) | Gluconic Acid(contains Gluconolactone)(45-50% in Water). Group: Molecular Biology. CAS No. 526-95-4. Pack Sizes: 25g, 500g. Molecular Formula: C6H12O7. US Biological Life Sciences. | Worldwide |
| Glucose Transporter Inhibitor III (STF-31) | A cell-permeable sulfonamide that selectively inhibits the growth of VHL-deficient renal cell carcinomas (RCCs) dose-dependently (0-5uM) by directly targeting glucose transporter 1 (GLUT1), which is up-regulated by HIF (hypoxia-inducible factor) transcription factor in VHL-deficient cells. It elicits decreased oxidative phosphorylation associated with aerobic glycolysis and leads to necrosis, which is consistent with the effect induced by GLUT1 RNA interference. It does not bind to other glucose transporters, and does not inhibit a broad range of 50 tested kinases. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Glutaminase Inhibitor, Compound 968 (5- (3-Bromo-4- (dimethylamino) phenyl) -2, 2-dimethyl-2, 3, 5, 6-tetrahydrobenzo [a]phenanthridin-4 (1H) -one, GAC Inhibitor, GLS1 Inhibitor I, KGA Inhibitor I, Kidney-Type Glutaminase Inhibitor I) | A cell-permeable benzophenanthridinone compound that acts as an allosteric and reversible inhibitor of mitochondrial glutaminase activity and represses the growth and invasive activity in glutaminase upregulated fibroblasts and in tumor cells (IC50 <10uM in NIH3T3 cells stably expressing Dbl, Cdc42-F28L, Rac-F28L or RhoC-F30L mutants and in SKBR3 and MDA-MB231 cancer cells). Shown to effectively shrink tumor size in P-493 B xenografted mouse model (200 µg per inj. i.p., 12 days). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Glutaminyl-Methionyl-Glutamyl-Glutamyl-Glutamyl-Alanyl-Valyl-Arginine Trifluoroacetate | Glutaminyl-Methionyl-Glutamyl-Glutamyl-Glutamyl-Alanyl-Valyl-Arginine Trifluoroacetate is a metabolite from Exenatide trypsin (Exenatide Acetate, E957300) digestion. Exenatide acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. Group: Biochemicals. Grades: Highly Purified. CAS No. 868249-03-0. Pack Sizes: 5mg, 25mg. Molecular Formula: C41H66F3N12O17S, Molecular Weight: 1088.08999999999. US Biological Life Sciences. | Worldwide |
| Glycerol 2-Methyl Ether | Glycerol 2-Methyl Ether is an derivative of Glycerol (G598400), used both in sample preparation and gel formation for polyacrylamide gel electrophoresis. Group: Biochemicals. Grades: Highly Purified. CAS No. 761-06-8. Pack Sizes: 100mg, 250mg. Molecular Formula: C4H10O3. US Biological Life Sciences. | Worldwide |
| Glyceryl Behenate | Glyceryl Behenate is a fat used in emulsification in the preparation of oral pharmaceutical formulations. Group: Biochemicals. Grades: Highly Purified. CAS No. 18641-57-1. Pack Sizes: 100mg, 250mg. Molecular Formula: C69H134O6, Molecular Weight: 1059.8. US Biological Life Sciences. | Worldwide |
| Glycine-13C2,15N Methyl Ester Hydrochloride | Glycine-13C2,15N Methyl Ester Hydrochloride is an intermediate in synthesizing Tiglyl Glycine-13C2,15N (T440102), which is a labelled derivative of Tiglyl Glycine (T440100), a metabolite a Isoleucine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C13C2H715NO2 HCl. US Biological Life Sciences. | Worldwide |
| Glycyrrhizic Acid-d3 | Isotope labelled Glycyrrhizic Acid (G735150) is a triterpene saponin used in the traditional Chinese medicinal preparation for its anti-inflammatory , antiulcerous and antiallergic effects. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C42H59D3O16, Molecular Weight: 825.95. US Biological Life Sciences. | Worldwide |
| Glyphosine (2- (bis (Phosphonomethyl) amino) acetic Acid, N, N-bis (Phosphonomethyl) glycine, Cp41845, Polaris) | A plant growth regulator that also enhances anti-B:9-23 (aa 9 to 23 of insulin B chain) TCR-dependent T cell activation (EC50 = 70.6nM; ECmax = 500nM) by modulating murine class II MHC I-Ag7-mediated B:9-23 presentation on APCs. Reported to augment B:9-23 in stimulating IL-10 production from splenocytes of diabetic NOD mice and PBMCs of type 1 diabetic individuals with HLA-DQ8, and effectively prevent the onset of diabetes in NOD mice (80mg/kg via daily i.p.). Group: Biochemicals. Grades: Highly Purified. CAS No. 2439-99-8. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| Gonadorelin Acetate | Gonadorelin Acetate is a gonadotropin-releasing hormone. Affects follicle stimulating hormones and leutinizing hormones. Group: Biochemicals. Grades: Highly Purified. CAS No. 71447-49-9. Pack Sizes: 10mg, 50mg. Molecular Formula: C55H75N17O13 (CH3COOH). US Biological Life Sciences. | Worldwide |
| GPCR-Helix 8 Signaling Inhibitor, JF5 (GPCR-H8 Signaling Inhibitor, JF5, 4-Pentyl-2,3-dihydro-1H-cyclopenta[b]quinolin-9-imine, HI, 4-Pentyl-1,2,3,4-tetrahydro-9H-cyclopenta[b]quinolin-9-imine, HI) | A cell-permeable quinolinimine compound that acts as a selective, potent blocker of G-protein coupled receptors (GPCR) that contain a constrained eighth helix (H8). The inhibition is selective and blocks G-protein signaling mediated via Gaq, but not Ga12. A non-orthosteric antagonist of PAR1 (IC50=4uM) that is shown to inhibit PAR1 and CCR-4 induced platelet aggregation without affecting PAR4 mediated aggregation. Shown to inhibit thrombus formation following vascular injury (IC50 ~1mg/kg). Also acts as a potent, non-competitive blocker of a2A-adrenergic receptors (IC50=2.5uM as shown by a decrease in 3H-yohimbine binding). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| GPR109b Agonist (1-(iso-Propyl)-1H-benzotriazole-5-carboxylic Acid) | A cell-permeable Niacin triazolo derivative that acts as a potent and selective agonist toward the human orphan G-protein-coupled receptor GPR109b/HM74, but not GPR109a/HM74A or b-adrenergic receptor. Effectively inhibits cAMP elevation induced by forskolin (5uM) and isoproterenol (1uM), respectively, in GPR109b-expressing CHO cells (EC50=400nM) and freshly isolated human adipocytes (EC50 about 1uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 306935-41-1. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| GPR119 Agonist, AS1269574 (G-Protein Coupled Receptor 119 Agonist, 2-((2-(4-Bromophenyl)-6-methylpyrimidin-4-yl)amino)ethanol, GPCR2 Agonist, MGC119957 Agonist, SNORF25 Agonist) | A pyrimidine compound that acts as an effective GPR119 agonist (EC50=2.5uM in stimulating cAMP in hGPR119-expressing HEK293 cells) and reportedly exhibits no activity toward B-adrenergic or GLP-1 receptors. Shown to enhance 16.8mM glucose-induced insulin secretion from murine MIN-6 B-cells (mU/20 min=0.44 and 0.22, respectively, with or without 10uM AS1269574) in vitro and improve glucose tolerance in normal mice (100mg/kg; p.o.) without any significant hypoglycemic effect in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 330981-72-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| GPR40 Agonist II (FFA1 Agonist II, Free Fatty Acid Receptor 1 Agonist II, 3- (4- ( (2, 6-Dichloropyridin-4-yl) ethynyl) phenyl) propanoic Acid) | A cell-permeable alkynedihydrocinnamic acid that acts as a potent GPR40/FFA1 agonist (EC50=40.7nM in inducing Ca2+ mobilization in hFFA1-expressing 1321N1 cells) with >100-fold selectivity over GPR43/FFA2, GPR41/FFA3, and a panel of 56 other receptors, ion channels, and transporters. Reported to enhance 12mM glucose-induced insulin secretion from rat INS-1E B-cells (by 34% at 10uM) and exhibit good aqueous solubility (199uM in PBS at pH 7.4), as well as chemical and metabolic stability. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| GPR43 (FFA2) Agonist ((S)-2-(4-chlorophenyl)-3,3-dimethyl-N-(5-phenylthiazol-2-yl)butanamide) | A phenylacetamide compound that acts as an allosteric agonist of FFA2 (GPR43), demonstrating a left-shifted acetate dose response (IC50=0.7uM) and 111% efficacy relative to acetate in hFFA2 forskolin-induced cAMP assays. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| GPR55 Receptor Antagonist, CID16020046 (4-[4-(3-Hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H-pyrrolo[3,4-c]pyrazol-5-yl]benzoic Acid) | A selective antagonist of G protein-coupled receptor 55 (GPR55) that blocks lipid L-a-lysophosphatidyl inositol (LPI)-induced GPR55 activation (IC50 = 1uM) and downstream effects in HEK293 cells. Also shown to block the agonistic effect of LPI on GPR55- expressing yeast cells (~10uM). Inhibits LPI-induced Ca2+ mobilization and ERK1/2 phosphorylation in HEK-GPR55 and HEK-CB1 cells. However, it does not affect basal Ca2+ mobilization and ERK1/2 activity. Blocks the GPR55-mediated NFAT and NF-kB activation and their nuclear translocation in HEK-GPR55 cells. Diminishes LPI-induced wound healing in GPR55-expressing primary human lung microvascular endothelial cells and reverses LPI-inhibited platelet aggregation (~10uM). Also reported to inhibit the activity of phosphodiesterases PDE3A and PDE4B (pIC50 = 5 and 4.8, respectively). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| GPR81 Agonist, 3Cl-5OH-BA (3-Chloro-5-hydroxybenzoic Acid, Hydroxycarboxylic Acid Receptor 1 Agonist) | A hydroxybenzoic acid compound that acts as a GPR81/HCA1-selective agonist (EC50 ~7, 16, 17, 22, and 67uM toward rat, human, monkey, mouse, and dog species, respectively) with little activity towards the homologous GPR109A/HCA2/HM74A GPCR. Orally active in mice and exhibits NEFAc cholesterol-lowering efficacy in overnight fasted C57B16/J mice (ED50 ~100mg/kg, p.o.) in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 53984-36-4. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| GR113808 (5-HT4 Serotonin Receptor Antagonist, GR113808, GR 113808, GR-113808) | A potent and selective antagonist of the serotonin 5-HT4 receptor (pki = 9.3-10.3). GR113808 is commonly used in brain and peripheral in vitro and in vivo in striatum studies (Guinea pig IC50 = 113nM, rat brain membrane Kd = 0.4-1nM) and in cAMP response in CHO and C6 glial cells (EC50 = 79-81nM). Group: Biochemicals. Grades: Highly Purified. CAS No. 144625-51-4. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
| GR 127935 Hydrochloride (5-HT1B/1D Serotonin Receptor Antagonist, GR 127935 Hydrochloride, GR-127935 Hydrochloride, GR127935 Hydrochloride) | A selective 5-HT1B/1D receptor antagonist. Selectivity was found to be similar for B (pki = 9.2-9.8) and D (pki = 8.6-9.1) receptor types. GR 127935 works well in vivo and was shown to block (+)-MDMA-induced hyperactivity in rats. It alters release of serotonin in the brain, as well as reducing drug-seeking behavior in cocaine addicted rats. In transformed rat C5 glioma cells, this inhibitor blocked 5HT with an IC50 = 97pM. Group: Biochemicals. Grades: Highly Purified. CAS No. 148642-42-6. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?·HCl. US Biological Life Sciences. | Worldwide |
| Granzyme A Positive Control (GZMA, Granzyme-1, CTL Tryptase, Cytotoxic T-lymphocyte-associated Serine Esterase 3, CTLA3, Cytotoxic T-lymphocyte Proteinase 1, Fragmentin-1, Hanukkah Factor, H Factor, HF, HFSP) | Granzyme A Positive Control (GZMA, Granzyme-1, CTL Tryptase, Cytotoxic T-lymphocyte-associated Serine Esterase 3, CTLA3, Cytotoxic T-lymphocyte Proteinase 1, Fragmentin-1, Hanukkah Factor, H Factor, HF, HFSP). Group: Molecular Biology. US Biological Life Sciences. | Worldwide |
| g-Secretase Inhibitor XX ( (S, S) -2-[2- (3, 5-Difluorophenyl) acetylamino]-N- (5-methyl-6-oxo-6, 7-dihydro-5H-dibenzo[b, d]azepin-7-yl) propionamide, DBZ, Dibenzazepine) | A cell-permeable dibenzazepine (dbz) compound that acts as a potent y-secretase inhibitor and significantly lowers both brain and plasma AB40 levels by ~72% in Tg2576 mutant APP transgenic mouse model (100umol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC50=1.7nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 and ApcMin mouse models (10umol/kg, i.p). CAS Number:209984-56-5. Group: Biochemicals. Grades: Highly Purified. CAS No. 209984-56-5. Pack Sizes: 500ug, 1mg. US Biological Life Sciences. | Worldwide |
| GSK-3beta Inhibitor XXIV (2-Methyl-5- (3-[4- (methylsulfinyl) phenyl) -1-benzofuran-5-yl) -1, 3, 4-oxadiazole, Racemic) | An orally bioavailable and blood-brain-barrier permeable oxadiazolo-benzofuranyl phenyl sulfoxide compound that acts as a potent, reversible and ATP-competitive inhibitor of GSK-3b (IC50=35nM, 34 and 140nM for racemic, (S)-9b eutomer and (R)-9b distomer). The (S)-9b eutomer displays excellent selectivity (IC50 > 10uM) over Cdk1/2/5, Chk1, p38a, JNK1, MEKK1, IKKb, PKCth, CK1d, EGFR, ErbB2, Src, Lck, IR, Tie2, c-Kit, c-Met, VEGFR2, FGFR3 and PDGFRa/b, and lowers tau phosphorylation at GSK-3b-Thr205 in a CWS (cold water stress) mouse model (3mg/kg, p.o.). Group: Biochemicals. Grades: Highly Purified. CAS No. 1005201-24-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| GSK-3beta Inhibitor XXV (GSK-3beta, N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine, 5-(4-Nitrophenyl)-N-(3-chloro-4-methyl)phenyl-1,3,4-oxadiazol-2-amine) | A blood brain barrier permeable oxadiazole compound that acts as a potent, reversible and ATP-competitive inhibitor of GSK-3b activity (IC50=17.1nM) with excellent selectivity over Cdk2 (22% inhibition at 10uM). Shown to elevate liver glycogen levels by ~3.5- and ~4.3-fold in C57BL/6N mice when dosed at 5 and 15mg/kg (i.p.) amounts. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??ClN?O?. US Biological Life Sciences. | Worldwide |
| GSK-3 beta Inhibitor XXVII (3-Amino-6-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide, HCl) | A cell-permeable pyridinyl pyrazinecarboxamide compound that acts as a highly potent, reversible, and ATP-competitive inhibitor of GSK-3b (Ki=4.9nM) with ~110-fold greater selectivity over Cdk2 (Ki=540nM). Shows only a trivial effect on the activities of 26-related kinases at much higher doses. Blocks GSK-3b-mediated phosphorylation of Ser396 in stably transfected 3T3 fibroblasts expressing four-repeat tau protein (IC50=76nM). Readily crosses blood-brain barrier and exhibits desirable bioavailability and aqueous solubility. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| GSK-3beta Inhibitor XXVII, CESI (2-(3-chloro-4-hydroxyphenyl)-8-(1,1-dioxidoisothiazolidin-2-yl)-3-hydroxy-6-methyl-4H-chromen-4-one) | A cell-permeable, 3-hydroxychromone derived compound that acts as a selective and reversible inhibitor of GSK-3beta (IC50 < 100nM). Shown to increase phosphorylation at Ser9. Does not show any inhibitory effect on a panel of 15 other protein kinases, including AMPK and Akt. By blocking GSK-3beta activity, it acts as a positive regulator of b-catenin signaling. Does not affect the viability or the growth rate of 3T3-L1 preadipocytes, however, it significantly reduces their differentiation into adipocytes ( 50 to 100nM). Exerts anti-adipogenic activity by down-regulating C/EBPa and PPARg. Shown to reduce adipocyte size and diminish weight gain in diet-induced obese mice without affecting their daily food intake. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??ClNO?S, Primary Target: GSK3b. US Biological Life Sciences. | Worldwide |
| GSK-3 Inhibitor, AR-A014418, (N-[(4-Methoxyphenyl)methyl]-N-(5-nitro-2-thiazolyl)urea) | Cell-permeable. A selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104nm). Inhibition is competitive with respect to ATP (Ki = 38nm). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 =um) and over 26 other kinases. Inhibits b-amyloid-mediated neurodegeneration in hippocampal slices. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
| GSK-3 Inhibitor IX ((2Z,3E)-6-Bromoindirubin-3-oxime) | A cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3a/b (IC50=5nM). Its specificity has been tested against various Cdk's (IC50=83, 300, 320, and 10,000nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively) as well as many other commonly studied kinases (IC50≥10uM), including MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK. Inhibition of GSK by BIO has been shown to result in the activation of Wnt-signaling pathway and sustained pluripotency in human and murine ESCs (embryonic stem cells). Reported to maintain self-renewal in human and mouse embryonic stem cells. Also induces the differentiation of neonatal cardiomyocytes. Group: Biochemicals. Grades: Highly Purified. CAS No. 667463-62-9. Pack Sizes: 1mg, 10mg. US Biological Life Sciences. | Worldwide |
| GTS-21 Dihydrochloride (DMBX-A, (E)-3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine, DMBX-A, alpha7 nAChR Agonist, GTS-21, Alpha 7 Nicotinic Acetylcholine Receptor Agonist, GTS-21) | A partial agonist selective for alpha7 nAChRs (EC50 = 10uM). Used in neuroimmunology studies, cardiovascular disease research, and Alzheimer's disease studies. Group: Biochemicals. Grades: Highly Purified. CAS No. 156223-05-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Guanfacine-13C, 15N3 Hydrochloride | Guanfacine-13C, 15N3 Hydrochloride is the labeled analogue of Guanfacine Hydrochloride (G816001), a Guanfacine centrally acting α-adrenoceptor agonist. Guanfacine is an antihypertensive. Group: Biochemicals. Grades: Highly Purified. CAS No. 1261393-21-8. Pack Sizes: 1mg. Molecular Formula: C813CH10Cl315N3O. US Biological Life Sciences. | Worldwide |
| GW 1100, GPR40 Antagonist (SB376752, 1-(4-Ethoxycarbonylphenyl)-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone) | A cell-permeable pyrimidinylmethyl-pyrimidinone compound that acts as potent, reversible and non-competitive GPR40 antagonist. Selectively blocks GPR40-mediated intracellular Ca2+ release stimulated by GPR40 Agonist GW9508 and linoleic acid (pIC50 of 5.99 in GPR40 expressing HEK293 cells) with no effect on GPR120-mediated activation. Shown to significantly reverse glucose-induced insulin secretion potentiated by GW9508 and only partially reduce linoleic acid effect in MIN6 cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 306974-70-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| GYKI 52466 Hydrochloride (1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine Hydrochloride, GYKI-52,466, GYK I52466) | A potent negative allosteric modulator selective for AMPA glutamate receptors (IC50 = 10-20uM) over kainate (IC50 ~450uM) and nMDA (IC50 >> 50uM) receptors. Commonly used as neuroprotectant, anticonvulsant, and skeletal muscle relaxant. Biologically viable admitted orally or systematically. Group: Biochemicals. Grades: Highly Purified. CAS No. 102771-26-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| GYKI 53655 Hydrochloride | A potent negative allosteric modulator selective for AMPA glutamate receptors (IC50 = 6 and 5uM for GluA1 and GluA4, respectively) over kainate receptors (IC50 = 63 and 32uM for GluK3 and GluK2b/GluK3 receptors. Used as neuroprotectant and anticonvulsant, and a valuable tool for the study of AMPA receptor-mediated processes in vivo. Group: Biochemicals. Alternative Names: LY 300168, GYKI-53655 Hydrochloride, AMPA Glutamate Receptor Antagonist, GYKI 53655 Hydrochloride, 1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine Hydrochloride. Grades: Highly Purified. CAS No. 143692-48-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| H-89 Dihydrochloride (PKA Inhibitor III, N- [2- ( (p-Bromocinnamyl ) amino) ethyl ]-5-isoquinolinesulfonamid e , 2HCl) | A cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase A (Ki = 48nM). Inhibits other kinases only at much higher concentrations: CaM kinase II (Ki = 29.7uM), casein kinase I (Ki = 38.3uM), myosin light chain kinase (Ki = 28.3uM), protein kinase C (Ki = 31.7uM), and ROCK-II (IC50 = 270nM). May be used to discriminate between the effects of PKA and cAMP-regulated guanine-nucleotide-exchange factors (GEFs) such as GEFI, GEFII, or Epac (exchange protein directly activated by cAMP). Enhances radiation-induced apoptosis in the human cell line BM 13674. Group: Biochemicals. Grades: Highly Purified. CAS No. 127243-85-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Haloxyfop-methyl-d4 | Haloxyfop-methyl-d4 is the isotope labelled analog of Haloxyfop-methyl; a herbicide used for selective post-emergence control of annual and perennial grasses in broadleaf crops. Group: Biochemicals. Alternative Names: 2-[4-[[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]oxy]phenoxy]-propanoic Acid Methyl Ester; Dowco 453; Dowco 453ME; Haloxyfop methyl ester; Haloxyfop-Me; Verdict; Verdict R. Grades: Highly Purified. CAS No. Unlabeled: 69806-40-2. Pack Sizes: 5mg, 50mg. Molecular Formula: C??H?D?ClF?NO?, Molecular Weight: 379.75. US Biological Life Sciences. | Worldwide |
| Haspin Kinase Inhibitor, CHR-6494 (3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine, Haploid Germ Cell-Specific Nuclear Protein Kinase Inhibitor, CHR-6494, Indazolyl-propylimidazopyridazin-amine) | A cell-permeable indazolyl imidazopyridazinamine compound that acts as a potent and reversible inhibitor of histone kinase haspin activity (IC50 = 2nM) with moderate selectivity over TrkA, GSK-3beta, PIM1, Cdk1/B and Cdk2/A (% inhibition at 100nM = 58, 48, 36, 34 and 33, respectively) among a panel of 27-kinases. Shown to block pH3-Thr3, with no effect on pH3-Ser10 and pH3-Ser28, cause mitotic catastrophe, upregulate BUB1 and cyclin B1 levels, and potently induce apoptosis (IC50 = 473, 500 and 752nM in HeLa, HCT-116 and MDA-MB-231 cells, respectively). Further, efficiently blocks bFGF-induced sprouting vessel by 70% at 1uM (chicken embryo aortic arch ring assay) and suppresses tumor growth in HCT-116 xenografted mouse model (50mg/kg, i.p.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| HDAC Inhibitor XVII ((E)-N-Hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamide, Histone Deacetylase Inhibitor XVII) | A cell-permeable N-hydroxycinnamide derivative that acts a highly potent and HDAC8-selective histone deacetylase inhibitor (IC50 = 27nM), displaying much reduced or little potency against HDAC1/3 (IC50 = 3.0uM), HDAC2/4/6/10/11 (IC50 >20uM), or total HDAC activity in HeLa nuclear extract (IC50 >10uM). Reported to preferentially inhibit the proliferation of human lung cancer cells CL1-5, H1299, and A549 (IC50 from 7 to 8uM), while being much less toxic to normal human lung IMR-90 cells (73% inhibition at 40uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??NO?, Primary Target IC50: 27nM. US Biological Life Sciences. | Worldwide |
| HDAC Inhibitor XXIII, Tubastatin A (N-Hydroxy-4-(2-methyl-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-ylmethyl)benzamide, HCl) | A cell-permeable carbazolohydroxamate compound that acts as a highly potent, reversible and active-site zinc-binding HDAC6 inhibitor with excellent selectivity among other HDAC isozymes (IC50=0.015, 0.854, 16.4uM for HDAC6, HDAC8 and HDAC1, respectively) with no activity towards HDAC2, 3, 4, 7, 9, 10 and 11 (IC50>30uM). Shown to induce a-tubulin hyperacetylation at 2.5uM, and offer complete neuroprotection in primary cortical rat neuronal cells against homocysteic acid (HCA)-induced oxidative stress at 10uM with no noticeable neurotoxicity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Hdm2 E3 Ligase Inhibitor II, HLI373 (5- (3-Dimethylaminopropyl amino) -3, 10-dimethyl-10H-pyrimido [4, 5-b] quinoline-2, 4-dione, 2HCl, MDM2 Inhibitor VI, MDM2 E3 Ligase Inhibitor II) | A cell-permeable pyrimidoquinoline-dione compound that acts as an efficient Hdm2 E3 ligase inhibitor, prevents Hdm2-mediated p53 ubiquitination and increases the cellular levels of both p53 and Hdm2 (IC50 ~3uM in RPE cells). Shown to selectively arrest the growth of several tumor cells in a p53-dependent manner and display desirable aqueous solubility. Group: Biochemicals. Grades: Highly Purified. CAS No. 502137-98-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Heat Shock Factor 1 Inhibitor, KRIBB11 (N2-(1H-Indazol-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine , HSF1 Inhibitor, KRIBB11, Heat Shock Protein Inhibitor III, p-TEFb hsp70 Promoter Recruitment Inhibitor, Hsp70 Induction Inhibitor II) | A cell-permeable 2,6-diaminopyridine compound that directly binds HSF1 and reversibly inhibits its transcriptional activity (IC50=1.2uM in heat shocked p[HSE]4-Ta-Luc transfected HCT-116 cells), and suppresses both the transcription and expression of hsp70, hsp47 and hsp27. Shown to block heat shock-induced p-TEFb (positive transcription elongation factor b) recruitment to the hsp70 promoter and inhibit the phosphorylation of RNA Pol II CTD-Ser2 with no effect on TNF-a-stimulated NF-kB activity in HeLa cells. Induces G2/M growth arrest and apoptosis (IC50 ~5uM in HCT-116 cells), and further decreases tumor growth in mouse xenograft regression model (50mg/kg, i.p.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Heliquinomycin (Rubymycin, NSC 702208) | Antibiotic. DNA helicase inhibitor. Inhibits the DNA helicase activity of the human minichromosome maintenance (MCM) 4/6/7 complex. Topoisomerase I and II inhibitor (weaker than DNA helicase). DNA and RNA synthesis inhibitor in cell culture. Does not inhibit protein synthesis. Induces cell cycle arrest. Anticancer compound. Antibacterial against Gram-positive bacteria. Group: Biochemicals. Grades: Purified. CAS No. 178182-49-5. Pack Sizes: 250ug, 500ug. Molecular Formula: C33H30O17. US Biological Life Sciences. | Worldwide |
| Hepatic Differentiation Inducer, SJA710-6 (2-(4-Bromophenyl)-N-(4-fluorophenyl)-3-propyl-3H-imidazo[4,5-b]pyridin-5-amine) | A cell-permeable imidazopyridinamine compound that selectively and potently induces differentiation of mesenchymal stem cells (MSCs) into hepatocyte-like cells (~47% at 5uM). Within 14 days of treatment with SJA710-6, the differentiated cells exhibit typical morphological characteristics of hepatocytes and are able to store glycogen, secret albumin, produce urea, and uptake LDL. Also, shown to increase the mRNA levels of hepatocyte-specific genes, such as albumin, AFP, CK18, c-Met, CYP1A1, CYP2B1, HNF3beta and FoxH1. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??BrFN?. US Biological Life Sciences. | Worldwide |
| Heptelidic Acid (Koningic acid, Avocettin, FO-4443, BRN 5091359) | A sesquiterpene antibiotic, isolated from Trichoderma sp. A potent and selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor. Binds to the essential Cys149 residue in the catalytic site of GAPDH. Selectively kills high-glycolytic cancer cells through glucose-dependent active ATP deprivation. Selective and competitive inhibitor of mammalian DNA polymerases beta, lambda and terminal deoxynucleotidyl transferase (TdT) in family X of pols. Group: Biochemicals. Grades: Highly Purified. CAS No. 74310-84-2. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
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