USBiological 4 - Products
Worldwide
Our biochemicals, antibodies, recombinant proteins, cell culture media and molecular biology kits are used in virtually all scientific applications.From affordable research quantities to larger bulk amounts.
| Product | Description | |
|---|---|---|
| Epoxomicin (BU-4061T, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N- [ (1S) -3-methyl-1 [ [ (2R) -2-methyloxiranyl] carbonyl] butyl] -L-threoninamide) | Originally isolated from Actinomycetes strain based on its potent in vivo antitumor activity, Epoxomicin is a potent, cell-permeable, selective and irreversible proteasome inhibitor. More potent inhibitor of the chymotrypsin-like activity of the proteasome than Lactacystin. Blocks also trypsin-like and PGPH activities of the proteasome. Group: Biochemicals. Grades: Highly Purified. CAS No. 134381-21-8. Pack Sizes: 50ug, 250ug. US Biological Life Sciences. |  Worldwide |
| ε-1,2,3,4,5,6-Hexachlorocyclohexane | ε-1,2,3,4,5,6-Hexachlorocyclohexane. Group: Biochemicals. Alternative Names: ε-BHC; ε-Benzene Hexachloride; ε-HCH; ε-Hexachlorocyclohexane; ε-Lindane (1α, 2α, 3α, 4 β,5 β,6 β)-1,2,3,4,5,6-Hexachlorocyclohexane. Grades: Highly Purified. CAS No. 6108-10-7. Pack Sizes: 1mg. Molecular Formula: C6H6Cl6, Molecular Weight: 290.83. US Biological Life Sciences. | Worldwide |
| ε-(γ-L-Glutamyl)lysine | ε-(γ-L-Glutamyl)lysine. Group: Biochemicals. Alternative Names: Nε(γ-Glutamyl)lysine; Nε-(γ-Glutamyl)-L-lysine; γ-Glutamyl-ε-lysine; ε-(L-γ-Glutamyl)-L-lysine; ε-(γ-Glutamyl)lysine; ε-(γ-L-Glutamyl)-L-lysine; εN-(γ-L-Glutamyl)lysine; L-N6-L-γ-Glutamyllysine. Grades: Highly Purified. CAS No. 17105-15-6. Pack Sizes: 100mg. Molecular Formula: C11H21N3O5, Molecular Weight: 275.3. US Biological Life Sciences. | Worldwide |
| ε-(γ-L-Glutamyl)lysine-d4 | ε-(γ-L-Glutamyl)lysine-d4. Group: Biochemicals. Alternative Names: Nε(γ-Glutamyl)lysine-d4; Nε-(γ-Glutamyl)-L-lysine-d4; γ-Glutamyl-ε-lysine-d4; ε-(L-γ-Glutamyl)-L-lysine-d4; ε-(γ-Glutamyl)lysine-d4; ε-(γ-L-Glutamyl)-L-lysine-d4; εN-(γ-L-Glutamyl)lysine-d4; L-N6-L-γ-Glutamyllysine-d4. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C11H17D4N3O5, Molecular Weight: 279.33. US Biological Life Sciences. | Worldwide |
| Equilin 3-Sulfate Sodium Salt (Stabilized with Tris, 50% w/w) | Metabolite of Equilin. Equilin 3-Sulfate Sodium Salt (Stabilized with TRIS, 50% w/w). Group: Biochemicals. Alternative Names: 3-(Sulfooxy)estra-1,3,5(10),7-tetraen-17-one Sodium Salt; 3-Hydroxyestra-1,3,5(10),7-tetraen-17-one Hydrogen Sulfate Sodium Salt; Sodium Equilin 3-Monosulfate; Sodium Equilin Sulfate. Grades: Highly Purified. CAS No. 16680-47-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| ERK Inhibitor VIII ((S)-4-(2-(2-Chloro-4-fluorophenylamino)-5-methylpyrimidin-4-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide) | A cell-permeable pyrimidylpyrrole compound that acts as an active site-targeting, highly potent and selective ERK1/2 inhibitor (KI <2nM against Erk2; [ATP] = 65uM), while inhibiting GSK-3, Aurora A, Cdk2 only at much higher concentrations (KI = 395, 540, and 852nM, respectively) and exhibiting much reduced or little potency toward a panel of more than 130 other kinases (KI ≥1.4uM; IC50 ≥1uM). Shown to effectively inhibit human colon carcinoma HT-29 proliferation (IC50 = 48nM) and restore EGFR inhibitor WZ4002 antiproliferation activity in WZR10 cultures (84% and no inhibition, respectively, by 100nM WZ4002 with or without 1uM Erk Inhibitor VIII co-treatment). Orally available in both mice and rats in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 896720-20-0. Pack Sizes: 10mg. Molecular Formula: C??H??Cl?FN?O?. US Biological Life Sciences. | Worldwide |
| ERO1 Inhibitor I, Erodoxin (Endoplasmic Reticulum Oxidase 1 Inhibitor, 1-Bromo-5-methoxy-2,4-dinitrobenzene) | A cell-permeable dinitrobromobenzene compound that acts as a selective inhibitor of yeast Endoplasmic Reticulum Oxidase 1 (ERO1), but has somewhat weaker activity against mouse ERO1a (IC50=400uM). Predicted to form thiol adducts and inhibits ERO1-dependent oxidation of thioredoxin-1 (Trx1) activity in vitro. Shown to cluster with genes involved in protein folding, glycosylation and cell wall biosynthesis, and delay carboxypeptidase Y (CPY) processing to the vacuolar form in wt-yeast cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C?H?BrN?O?, Molecular Weight: 277. US Biological Life Sciences. | Worldwide |
| ERO1 Inhibitor II, EN460 | A cell-permeable thiol reactive enone (EN) compound that selectively interacts with the active-site cysteine of reduced, active form of ERO1alpha and inhibits its activity (IC50 = 1.9uM). Also prevents ERO1 re-oxidation both in vitro and in mouse embryonic fibroblasts. Activates the unfolded protein response and protects ER-stressed 293T cells. Can inhibit ERO1alpha even in the presence of an excess amount of competing thiols. Can inhibit ERO1alpha even in the presence of an excess amount of competing thiols. EN460 binding to ERO1alpha is shown to promote the loss of flavin adenine dinucleotide (FAD) from the holoenzyme. Its inhibitory action appears to be irreversible, however addition of FAD and tris (hydroxypropyl) phosphine can restore some enzyme activity. Group: Biochemicals. Alternative Names: (Z)-2-Chloro-5-(4,5-dihydro-5-oxo-4-((5-phenyl-2-furanyl)methylene)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzoic Acid, (Z)-2-Chloro-5-(5-oxo-4-((5-phenylfuran-2-yl)methylene)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)benzoic Acid. Grades: Highly Purified. CAS No. 496807-64-8. Pack Sizes: 25mg. Molecular Formula: C??H??ClF?N?O?, Molecular Weight: 460.8. US Biological Life Sciences. | Worldwide |
| Erucic Acid Methyl-d3 Ester | Erucic Acid Methyl-d3 Ester is labelled Erucic Acid Methyl Ester (E649915), the methyl ester of Erucic acid (E649900) which is a long-chain alcohol that acts as an inhibitor of fatty acid oxidation in the heart. Erucic acid originates in rapeseed plants, and is the major fatty acid constituent of rapeseed plant oil extracts and canola oil. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg, 250mg. Molecular Formula: C23H41D3O2, Molecular Weight: 355.61. US Biological Life Sciences. | Worldwide |
| Estriol 16-O- β-D-Glucuronide | Estriol 16-O- β-D-Glucuronide is a glucuronide derivative of Estriol (E888960); a metabolite of Estradiol that is considerably less potent than Estradiol itself. Group: Biochemicals. Grades: Highly Purified. CAS No. 1852-50-2. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C24H32O9, Molecular Weight: 464.51. US Biological Life Sciences. | Worldwide |
| Ethyl 2-Bromobenzoate | Ethyl 2-bromobenzoate is an intermediate of 7H-Benzo[c]fluorene, which is a polycyclic aomatic hydrocarbon (PAH) with mutagenic activity. 7H-Benzo[c]fluorene is a major DNA adduct-forming component of coal tar. Recent studies suggest that 7H-Benzo[c]fluorene may be capable of inducing lung tumors. Group: Biochemicals. Grades: Highly Purified. CAS No. 6091-64-1. Pack Sizes: 10g, 25g. Molecular Formula: C9H9BrO2. US Biological Life Sciences. | Worldwide |
| Ethyl 5- (4-chlorophenyl) nicotinate | Ethyl 5- (4-chlorophenyl) nicotinate. Group: Biochemicals. Grades: Highly Purified. CAS No. 1258269-08-7. Pack Sizes: 100mg, 250mg. Molecular Formula: C14H12ClNO2, Molecular Weight: 261.7. US Biological Life Sciences. | Worldwide |
| Ethyl Butyrate | Ethyl Butyrate, is used in the preparation of novel 2-cyanopyrimidines as cathespin K inhibitors. Also used in the synthesis of pyridobenzimidazole derivatives exhibiting antifungal activity by the inhibition of β-1,6-glucan. Group: Biochemicals. Grades: Highly Purified. CAS No. 105-54-4. Pack Sizes: 5g, 25 g. Molecular Formula: C6H12O2. US Biological Life Sciences. | Worldwide |
| Ethylene Terephthalate Cyclic Hexamer-d24 | Isotope labelled Ethylene Terephthalate Cyclic Hexamer is an impurity in the synthesis of Ethylene Terephthalate Cyclic Trimer (E917715). Ethylene Terephthalate Cyclic Trimer can be used as migration indicators into foods and simulants, for microwave-active materials. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C60H24D24O24, Molecular Weight: 1177.16. US Biological Life Sciences. | Worldwide |
| Ethylhydrocupreine Hydrochloride | Ethylhydrocupreine Hydrochloride is a reagent used in the alteration in bacterial morphology. Also, it inhibits methylene blue (MB) reductase activity; Anti-pneumococcal analog of quinine-HC1 which stimulated the diaphorase activity of pig heart muscle and Escherichia coli lipoyl dehydrogenase. Group: Biochemicals. Grades: Highly Purified. CAS No. 3413-58-9. Pack Sizes: 50mg, 100mg. Molecular Formula: C21H28N2O2 HCl, Molecular Weight: 340.46. US Biological Life Sciences. | Worldwide |
| Ethyl Maltol-d5 | Isotope labelled Ethyl Maltol is an extract from medicinal plants such as P. Incarnata and can be used as an anticonvulsant, acting as a depressant, and on motor activity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C7H3D5O3, Molecular Weight: 145.169999999999. US Biological Life Sciences. | Worldwide |
| EUK-118 ((acetato- kO)[[2, 2'- [1, 2- ethanediylbis[(nitrilo- κ N)methylidyne]]bis[3, 5- dimethoxyphenolato- κO]](2- )]- manganese) | A structural analog of EUK 8 and EUK 134 with significantly reduced activity. Acts as a synthetic catalytic scavenger of reactive oxygen species with superoxide dismutase (SOD) and catalase mimetic activity. Superoxide-mediated reduction of an electron acceptor (i.e., SOD mimetic activity) was inhibited by EUK 118 with an IC50 value of 2.0um. Group: Biochemicals. Grades: Highly Purified. CAS No. 186299-34-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| EUK-124 (chloro[[2, 2- [1, 2- ethanediylbis[(nitrilo- κN)methylidyne) | A structural analog of EUK 8 and EUK 134 with significantly reduced activity. Acts as a synthetic catalytic scavenger of reactive oxygen species with superoxide dismutase (SOD) and catalase mimetic activity. EUK 124 inhibits superoxide-mediated reduction of an electron acceptor (i.e., SOD mimetic activity), with an IC?? value of 5.0um. Group: Biochemicals. Grades: Highly Purified. CAS No. 186299-35-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| EUK-134 (chloro[[2, 2'- [1, 2- ethanediylbis[(nitrilo- κ N)methylidyne]]bis[6- methoxyphenolato- κO]]]- manganese) | A synthetic superoxide dismutase (SOD)/catalase mimetic. EUK 134 is a salen-manganese complex that has been modified to increase its catalase activity while retaining SOD activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 81065-76-1. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Ezh2 Inhibitor II, EI1(Enhancer of Zested Homolog 2 Inhibitor II, HMTase Inhibitor XI, 6-Cyano-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-(pentan-3-yl)-1H-indole-4-carboxamide) | A cell-permeable indolocarboxamide compound that acts as a potent and selective inhibitor against Ezh2/PRC2 (Polycomb repressive complex 2; Ezh2 / SUZ12 / EED / AEBP2 / RbAP48) HMTase activity (IC50/substrate = 15nM/H3K27me021-44 and 13nM/H3K27me221-44, respectively, against human wt or Y641F Ezh2-containing PRC2; [SAM] = 1uM) in a cofactor SAM-competitive manner, while inhibiting Ezh1/PRC2 only at much higher concentrations (IC50 = 1.34uM) and exhibiting no potency toward CARM 1, Dot1L, G9a, MLL, NSD3, Set7/9, SETD2, SETD8, SmyD2, or Suv39H2 (IC50 >100uM). Shown to suppress cellular H3K27 dimethylation and trimethylation (1 to 10uM) in DLBCL cultures and exhibit antiproliferation activity against DLBCL cell lines with wt or mutant Ezh2 (3.3uM to 10uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?, Primary Target: Ezh2/PRC2. US Biological Life Sciences. | Worldwide |
| Ezrin Inhibitor, NSC668394 (7- (3, 5-dibromo-4-hydroxyphenethylamino) quinoline-5, 8-dione) | A cell-permeable, quinoline that binds directly to ezrin (=12.6uM) in a reversible manner, and inhibits PKC?-mediated ezrin phosphorylation at Thr567 (IC50=8.1uM) and ezrin-actin binding, in vitro. It also inhibits murine osteosarcoma K7M2 cell invasion in a monolayer of HUVEC cells, dose-dependently, from 1 to 10uM. At 10uM, it causes a unique developmental defect in zebrafish, characterized by reduced motility of eye progenitor cells. Furthermore, this small molecule prevents metastatic growth in an ex vivo mouse lung organ culture assay at 10uM and attenuates ezrin-dependent OS metastatic growth in mouse lung model in vitro at 2.26mg/kg/day. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| FAAH Inhibitor III, URB937 (Cyclohexylcarbamic acid-(3-carbamoyl-6-hydroxybiphenyl-3-yl)ester, Fatty Acid Amide Hydrolase Inhibitor III, URB937, Cyclohexylcarbamic acid-carbamoyl hydroxybiphenyl-3-yl) ester) | A blood-brain-barrier impermeable p-hydroxyphenylcarbamate compound that acts as a potent and irreversible inhibitor of FAAH activity (IC50 = 26.8nM rat brain) with excellent selectivity over monoacylglycerol lipases (IC50 > 100uM). Shown to rapidly block mouse liver FAAH activity over brain (ED50 = 0.2mg/kg vs. 40mg/kg, s.c.), elevate anandamide and palmitoylethanolamide levels in peripheral tissues (1mg/kg, i.p.) and exert antinociceptive action. The CNS-penetrant FAAH Inhibitor II, URB597 is also available. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| FATP2 Inhibitor, CB-2 | A cell permeable thioxothiazolindine compound that reversibly inhibits FATP2-mediated long chain fatty acid uptake in Caco-2 and HepG2, but not non-FATP2-expressing 3T3-L1 adipocytes, cultures (IC50 = 3.99, 7.55, and 231.1uM, respectively), while exhibiting much reduced potency toward cellular Acsl (acyl-CoA synthetase) activity (IC50 = 50uM). Shown not to affect Caco-2 viability, membrane permeability, or glucose transport. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??BrClNO?S?, Primary Target IC50: 8u. US Biological Life Sciences. | Worldwide |
| Fbxo3 Inhibitor, BC-1215 (N1,N2-bis(4-(Pyridin-2-yl)benzyl)ethane-1,2-diamine, F Box Only Protein 3 Inhibitor, F Box Protein 3 Inhibitor, BC1215, F Box and Leucine-rich Repeat Protein 2 Activator, Fbxl2 Activator) | A cell-permeable, bis-pyridinyl benzyl ethanamine that disrupts Fbxo3-Fbxl2 interaction and effectively prevents SCF-Fbxo3-catalyzed Fbxl2 ubiquitination, resulting in cellular Fbxl2 upregulation and thereby SCF-Fbxl2-catalyzed TRAFs (TNF Receptor-Associated Factors) ubiquitination. Effectively reduces cellular TRAFs (5 to 127uM) and prevents TRAF-mediated cytokines production from LPS-stimulated human PBMC (25uM). Shown to greatly prevent Cecal Ligation & Puncture-induced plasma cytokine elevation and substantially reduce the severity of lung inflammation post intratracheal P. aeruginosa infection in mice (100ug/mouse; i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?, Primary Target: Fbox3. US Biological Life Sciences. | Worldwide |
| Fenbendazole-Amine Sulfoxide | Fenbendazole-Amine Sulfoxide is a highly effective inhibitor of the helminth-specific enzyme, fumarate reductas in Ascaris suum. Also, it inhibits the polymerization of tubulin into microtubules in vitro. Group: Biochemicals. Grades: Highly Purified. CAS No. 69489-26-5. Pack Sizes: 10mg, 25mg. Molecular Formula: C13H11N3OS, Molecular Weight: 257.31. US Biological Life Sciences. | Worldwide |
| Fenbendazole (Methyl 5- (phenyl thio) -2-benzimidazolecarbamate , FZ) | An anthelmintic drug belonging to the benzimidazole group mainly used for the treatment of pinworm in animals. Recently, fenbendazole has been shown to selectively induce cytotoxicity in cancer cells via impairment of proteasomal function and induction of unfolded protein response. Group: Biochemicals. Grades: Highly Purified. CAS No. 43210-67-9. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Fenobam (N-(3-Chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea) | A potent negative allosteric modulator highly selective for mGluR5 (IC50 = 87nM; Kd = 54nM and 31nM at recombinant mGlu5 receptors of rat and human, respectively). Biologically active admitted orally or systematically. Frequently used for assessing the functional roles of mGlu5 receptors in a variety of brain functions (i.e. learning and memory, circadian rhythms, reward and decision making, and locomotion) and disorders (i.e. addition, depression, seizures, anxiety disorder, Parkinsons disease, Alzheimers disease, and Down syndrome). A leading therapeutic candidate for treatment of fragile X syndrome. Group: Biochemicals. Grades: Highly Purified. CAS No. 57653-26-6. Pack Sizes: 5mg. Molecular Formula: C??H??ClN?O?, Primary Target: mGlu5 receptors. US Biological Life Sciences. | Worldwide |
| Ferrostatin-1 | Cell-permeable. A potent ferroptosis (an iron-dependent form of non-apoptotic cell death) inhibitor. Inhibits erastin-induced ferroptosis in HT-1080 cells with an EC50 of 60nm. Ferrostatin-1 inhibits ferroptosis in cancer cells as well as blocks glutamate-induced cell death in organotypic rat brain slices. Group: Biochemicals. Alternative Names: Fer-1, Ethyl 3-amino-4- (cyclohexylamino) benzoate. Grades: Highly Purified. CAS No. 347174-05-4. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Ferrostatin-1 (Ferrostatin1, Ethyl-3-amino-4- (cyclohexylamino) benzoate) | A cell-permeable 3,4-diaminoethylbenzoate-based antioxidant that effectively prevents Glutamate- (5mM; 3h) induced neurotoxicity in cultured rat OHSC (by 56%, 65%, and 71%, respectively, in CA1, CA3, and Dentrate gyrus; [Fer-1] = 2uM, added 0.5h prior to Glutamate) and Erastin- (50uM; 24h) induced HT-1080 death (EC50 = 60nM) by blocking cytosolic and lipid ROS accumulation (by >80% at 0.5uM in 10uM Erastin-treated HT-1080 cells). Fer-1 does not prevent H2O2- induced necrosis, STS-induced apoptosis, or Iron-independent oxidative death by Rotenone. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| FeTPPS | A peroxynitrite decomposition catalyst. An iron porphyrin complex that catalytically isomerizes peroxynitrite to nitrate both in vivo and in vitro thus serving as a decomposition catalyst and a selective peroxynitrite scavenger. Does not complex with nitric oxide and exhibits little SOD mimetic activity. Group: Biochemicals. Alternative Names: 5, 10, 15, 20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron (III), Chloride. Grades: Highly Purified. CAS No. 90384-82-0. Pack Sizes: 25mg, 100mg. US Biological Life Sciences. | Worldwide |
| FFN511 (Fluorescent False Neurotransmitter 511, Vesicle Monoamine Transporter (VMAT2) Substrate, FFN511) | A fluorescent false neurotransmitter that acts as an optical tracer that inhibits serotonin binding to VMAT2-containing membranes (IC50 = 1uM). Compound has been used to assess the functional status of TH positive neurons by fluorescent measurement of uptatke and release. Group: Biochemicals. Grades: Highly Purified. CAS No. 1004548-96-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Fidaxomicin (Lipiarmycin) | Fidaxomicin is a non-absorbed macrocyclic antibiotic, and is the first antimicrobial to be approved by the FDA for the treatment of Clostridium difficile infection (CDI) in 20 years. Fidaxomicin works by inhibiting sporulation by CDI, sustaining clinical response and reducing recurrences of this pathogen. Group: Biochemicals. Alternative Names: 3E, 5E, 8S, 9E, 11S, 12R, 13E, 15E, 18S)-3-[[[6-Deoxy-4-O-(3, 5-dichloro-2-ethyl-4, 6-dihydroxybenzoyl)-2-O-methyl- β -D-mannopyranosyl] oxy] methyl] -12- [ [6-deoxy-5-C-methyl-4-O- (2-methyl-1-oxopropyl) - β-D-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-oxacyclooctadeca-3,5,9,13,15-pentaen-2-one; Clostomicin B1; Dificid; Dificlir; Fidaxomicin; Fidaxomycin; Lipiarmicin; Lipiarmycin; Lipiarmycin A 3; OPT 80; PAR 01; PAR 101; R-Tiacumicin B; Tiacumicin. Grades: Highly Purified. CAS No. 873857-62-6. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C??H??Cl?O??, Molecular Weight: 1058.04. US Biological Life Sciences. | Worldwide |
| Finasteride (MK 906, L-652,931, BRN 4269024 ) | Potent, specific and competitive inhibitor of type II 5alpha-reductase (enzyme which converts testosterone to the more potent 5alpha-dihydrotestosterone). Anticancer compound. Apoptosis modulator. Enhances the action of GABA at GABA(A) receptors, which leads to neurological implications. Inhibit testosterone-induced type I procollagen and TGF-b1 expression in human scalp dermal fibroblasts in a model of androgenic alopecia. Drug for the treatment of male androgenetic alopecia. Potential role in neuropsychiatric disorders. Group: Biochemicals. Grades: Highly Purified. CAS No. 98319-26-7. Pack Sizes: 100mg, 500mg. Molecular Formula: C23H36N2O2, Form: Supplied as a white to off-white. US Biological Life Sciences. | Worldwide |
| Flumazenil (GABAA Receptor Antagonist, Flumazenil, Ro 15-1788) | A competitive blocker of benzodiazepine activation of inhibitory GABAergic synpases (ID50 = 200ug/kg/i.p). Binds to the benzodiazepine site of GABAA receptors. Enhances GABAA-receptor mediated currents and antagonizes the enhancing effects of benzodiapine agonist flurazepam. Exhibits fast association and dissociation from the benzodiazepine binding site. Permeates the blood brain barrier, however, the level of uptake may depend on efflux effects of p-glycogprotein transporter. Group: Biochemicals. Grades: Highly Purified. CAS No. 78755-81-4. Pack Sizes: 10mg. Molecular Formula: C??H??FN?O?. US Biological Life Sciences. | Worldwide |
| Fluorescein-O'-acetic Acid | Fluorescein-O'-acetic acid is a fluorescent label which reacts with amines after activation to give isomerically homogeneous derivatives. It is a fluorescent label. Group: Biochemicals. Grades: Highly Purified. CAS No. 233759-98-3. Pack Sizes: 5mg, 10mg. Molecular Formula: C22H14O7, Molecular Weight: 390.34. US Biological Life Sciences. | Worldwide |
| Fmoc- (3S) -3-amino-1-carboxy methyl caprolactame | Fmoc- (3S) -3-amino-1-carboxy methyl caprolactame is used in the synthesis of unsubstituted piperazinone-based transition state factor Xa inhibitors. It is also used to prepare peptidomimetics containing Freidinger lactams as STAT3 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 142855-79-6. Pack Sizes: 250mg, 500mg. Molecular Formula: C23H24N2O5. US Biological Life Sciences. | Worldwide |
| Fmoc-hLeu-OH | Fmoc-hLeu-OH. Group: Biochemicals. Grades: Highly Purified. CAS No. 180414-94-2. Pack Sizes: 1g, 5g. Molecular Formula: C??H??NO?, Molecular Weight: 367.44g/mol. US Biological Life Sciences. | Worldwide |
| Fmoc-homoArg(Pbf)-OH | Fmoc-homoArg(Pbf)-OH is a useful tool for the introduction of homoarginine during Fmoc SPPS. It can be used in exactly the same manner as Fmoc-Arg(Pbf)-OH. Group: Biochemicals. Grades: Highly Purified. CAS No. 401915-53-5. Pack Sizes: 1g, 5g. Molecular Formula: C??H??N?O?S, Molecular Weight: 662.80g/mol. US Biological Life Sciences. | Worldwide |
| Fmoc-N-Me-Asp(OtBu)-OH | Fmoc protected N-methyl amino acid suitable for solid phase peptide synthesis. N-methyl amino acids have been shown to improve proteolytic stability of peptides. Group: Biochemicals. Alternative Names: N-α-Fmoc-N-α-methyl-L-aspartic acid β-tert butyl ester. Grades: Purified. CAS No. 152548-66-8. Pack Sizes: 250mg, 1g. US Biological Life Sciences. | Worldwide |
| Fmoc-N-Me-Cys(Trt)-OH | Molecular Weight: Group: Biochemicals. Grades: Highly Purified. CAS No. 944797-51-7. Pack Sizes: 250mg, 1g. US Biological Life Sciences. | Worldwide |
| Fmoc-Tyr(S03nP)-OH | A novel derivative for the synthesis of sulfotyrosine-containing peptides by Fmoc SPPS. The sulfate neopentyl group is stable to TFA, and thus protects the sulfotyrosine residue from degradation during the cleavage reaction, but is easily cleaved post-cleavage by treatment of the peptide with aqueous ammonium acetate. Group: Biochemicals. Grades: Highly Purified. CAS No. 878408-63-0. Pack Sizes: 1g. Molecular Formula: C??H??NO?S, Enantiomeric. US Biological Life Sciences. | Worldwide |
| Focal Adhesion Kinase Inhibitor III (FAK Inhibitor III, N-(4-tert-Butylbenzyl)-1,5-dimethyl-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazin-8-amine-4,4-dioxide) | A cell-permeable pyrazolobenzothiazined ioxide compound that targets and locks FAK in its inactive conformation, resulting in preincubation time-dependent inhibition in kinase assays and FAK autophosphorylation in human prostate cancer PC3M-luc cells (IC50 = 7.1uM with 30 min inhibitor preincubation), while exhibiting little activity toward Akt1, Aurora B, HER2, MEK1, p38alpha, Pyk2, or Src even at concentrations as high as 10uM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
| Formamide-13C | Isotope labelled Formamide is a compound that is used in biochemistry to prevent RNA samples from degradation due to RNAses. Formamide is also used as a plasticizer to prepare thermoplastic starch (TPS), a special type of starch that can be mixed with other synthetic polymers because of its unique ability to ÂflowÂ. Group: Biochemicals. Grades: Highly Purified. CAS No. 51284-91-4. Pack Sizes: 50mg, 100mg. Molecular Formula: 13CH3NO. US Biological Life Sciences. | Worldwide |
| Forskolin (Boforsin, Colforsin, Coleonol, NSC 357088, NSC 375489) | Potent, cell permeable adenylyl cyclase activator. Increases intracellular cAMP levels. Widely used tool to investigate cAMP as a second messenger. Inotropic and antihypertensive. Smooth muscle relaxant/vasodilator. Glucose transporter inhibitor. Platelet aggregation inhibitor. Stimulates lipolysis in fat cells. Non-competitive nicotinic acetylcholine receptors inhibitor. MAP kinase inhibitor. Upregulates mitochondrial uncoupling protein (UCP) mRNA levels in brown adipose tissue. Autophagy inhibitor. Hedgehog signaling inhibitor. Has antiglaucoma potential. Promotes neuronal differentiation of NSCs. Group: Biochemicals. Grades: Highly Purified. CAS No. 66575-29-9. Pack Sizes: 1mg, 5mg, 25mg, 50mg. US Biological Life Sciences. | Worldwide |
| Forskolin (Coleus forskohlii) | The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC50 = 4uM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na+ permeability that results in indirect augmentation of Ca2+ release. Inhibits MAP kinase in rat renal mesangial cells (IC50 = 25uM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes. Group: Biochemicals. Grades: Highly Purified. CAS No. 66575-29-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Forskolin, Coleus forskohlii (7b-Acetoxy-8,13-epoxy-1α,6 β,9α-trihydroxy-labd-14-en-11-one, Colforsin) | The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC50=4uM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na+ permeability that results in indirect augmentation of Ca2+ release. Inhibits MAP kinase in rat renal mesangial cells (IC50= 25uM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes. Group: Biochemicals. Grades: Highly Purified. CAS No. 66575-29-9. Pack Sizes: 10mg, 25mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
| Foxo1 Inhibitor, AS1842856 (5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid) | A cell-permeable oxodihydroquinoline that preferentially inhibits the transcription activity of Forkhead box O family member Foxo1 (IC503nM) over that of the functionally related Foxo3a and Foxo4 (70%, 20%, and 3% inhibition, respectively, in HepG2-based reporter assays; [AS184256]0nM) via direct binding of the active Foxo1, but not the Ser256-phosphorylated / inactive form of Foxo1. Shown to inhibit gluconeogenesis in rat heptoma Fao cultures (IC50CnM against glucose production) in vitro and in liver of both non-diabetic and diabetic mice during a 26-hour fasting period (100mg/kg/8h p.o.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??FN?O?, Molecular Weight: 347.4. US Biological Life Sciences. | Worldwide |
| FTY720 Hydrochloride (Gilenya, 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol. HCl, Fingolimod) | Cell permeable immunosuppressor displaying lymphocyte sequestration properties and used for treatment in multiple sclerosis. Potent sphingosine 1-phosphate (S1P) receptor (S1P1, S1P3, S1P4, and S1P5) agonist when phosphorylated by sphingosine kinase. Sphingosine transporter Abcb1 and leukotriene C4 transporter Abcc1 activity enhancer. Cytosolic phospholipase A2 inhibitor, independent of sphingosine 1-phosphate receptors. Autophagy inducer. Apoptosis inducer. Group: Biochemicals. Grades: Highly Purified. CAS No. 162359-56-0. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Fucoidan | Fucoidan is a polysaccharide composed predominantly of sulfated fucose. Group: Biochemicals. Grades: Highly Purified. CAS No. 9072-19-9. Pack Sizes: 500mg, 1000mg. Molecular Formula: N/A, Molecular Weight: US Biological Life Sciences. | Worldwide |
| Fulvic Acid | Free radical scavenger and antioxidant. Potential compound to neutralize radioactive and toxic wastes and "heal" soils. Chelates and binds scores of minerals into a bioavailable form used by cells. Shown to incorporate into bone and cartilage of rats. Antibacterial. Antifungal. beta-Hexosaminidase release inhibitor. Anti-inflammatory. Tau fibrils aggregation inhibitor (Alzheimers Disease). Antiseptic. Interrupts the dimer formation of Abeta (17-42) peptides. Group: Biochemicals. Alternative Names: 4,10-dihydro-3,7,8-trihydroxy-3-methyl-10-oxo-1H,3H-pyrano[4,3-b][1]benzopyran-9-carboxylic acid. Grades: Highly Purified. CAS No. 479-66-3. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
| Fumigaclavine A | Ergot alkaloid. Mycotoxin.CAS Number:6879-59-0. Group: Biochemicals. Alternative Names: (6aR,9R,10S,10aR)-7,9-Dimethyl-4,6,6a,7,8,9,10,-10a-octahydroindolo[4,3-fg]quinolin-10-yl acetate. Grades: Highly Purified. CAS No. 6879-59-0. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| Fumitremorgin C (Tryptoquivaline) | Mycotoxin. Tremorgenic. Potent and specific inhibitor of the breast cancer resistance protein (BCRP; ABCG2). Reverses multidrug resistance mediated by BCRP and increases cytotoxicity of several anticancer agents in vitro. Group: Biochemicals. Grades: Highly Purified. CAS No. 118974-02-0. Pack Sizes: 250ug, 1mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| Funalenone (3,4,7,9-Tetrahydroxy-6-methyl-1H-phenalen-1-one) | Matrix metalloproteinase-1 (MMP-1; Type I collagenase) inhibitor. HIV-1 integrase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 259728-61-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Fuscin | Mycotoxin. Antibacterial agent. ADP transport inhibitor. Human CCR5 receptor antagonist. Anti-HIV compound. Mitochondrial respiration and oxidative phosphorylation inhibitor. Group: Biochemicals. Alternative Names: 3,4,7,9-Tetrahydroxy-6-methyl-1H-phenalen-1-one, 9,10-Dihydro-5-hydroxy-4,8,8-trimethyl-2H,4H-benzo[1,2-b:4,3-c]dipyran-2,6(8H)-dione. Grades: Highly Purified. CAS No. 83-85-2. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
| GALC, Positive Control (Galactocerebrosidase, GALCERase, Galactocerebroside beta-galactosidase, Galactosylceramidase, Galactosylceramide beta-galactosidase) | GALC, Positive Control (Galactocerebrosidase, GALCERase, Galactocerebroside beta-galactosidase, Galactosylceramidase, Galactosylceramide beta-galactosidase). Group: Molecular Biology. Pack Sizes: 15ul. US Biological Life Sciences. | Worldwide |
| Galectin-1 Antagonist, DB21 (SVQNvaKL-[DBF]-IIVKLNA) | A dibenzofuran conjugated peptidomimetic (13-mer) that acts as an allosteric inhibitor of galectin-1 binding to cell surface glycans (IC50 = 3uM). Shown to reduce the proliferation of endothelial cells and reduce vessel density in murine tumor models. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C??H???N??O??, Sequence: SVQMKNva-[DBF]-IIVKLNA. US Biological Life Sciences. | Worldwide |
| Gallic Acid-d2 | Gallic Acid-d2 is the labelled analogue of Gallic acid (G188978) which is a phenolic acid with antioxidant activity. Gallic acid was found to protect human cells against oxidative damage and showed cytotoxicity against cancer cells. Gallic Acid and its esters also show antiviral and antifungal activities. Group: Biochemicals. Grades: Highly Purified. CAS No. 294660-92-7. Pack Sizes: 2.5mg, 10mg. Molecular Formula: C7H4D2O5, Molecular Weight: 172.13. US Biological Life Sciences. | Worldwide |
| γ-Amino-2-methylbenzenepropanol | γ-Amino-2-methylbenzenepropanol. Group: Biochemicals. Alternative Names: 3-Amino-3-o-tolyl-1-propanol; 3-Amino-3-(2-methylphenyl)-1-propanol. Grades: Highly Purified. CAS No. 21464-52-8. Pack Sizes: 250mg. Molecular Formula: C10H15NO, Molecular Weight: 165.23. US Biological Life Sciences. | Worldwide |
| γ-Amino-benzenepentanoic Acid | γ-Amino-benzenepentanoic Acid. Group: Biochemicals. Alternative Names: (γS)-Amino-benzenepentanoic Acid. Grades: Highly Purified. CAS No. 916198-97-5. Pack Sizes: 5mg. Molecular Formula: C11H15NO2, Molecular Weight: 193.24. US Biological Life Sciences. | Worldwide |
| γ-Butyrolactone-13C4 | γ-Butyrolactone-13C4. Group: Biochemicals. Alternative Names: Dihydro-2(3H)-Furanone-2,3,4,5-13C4. Grades: Highly Purified. CAS No. 848486-92-0. Pack Sizes: 500ug. Molecular Formula: 13C4H6O2, Molecular Weight: 90.06. US Biological Life Sciences. | Worldwide |
| γ-Chlordane | γ-Chlordane. Group: Biochemicals. Alternative Names: (1R,2R,3aS,4S,7R,7aS)-rel-1,2,4,5,6,7,8,8-Octachloro-2,3,3a,4,7,7a-hexahydro-,4,7-methano-1H-indene; (1α,2 β,3aα,4 β,7 β,7aα)-1,2,4,5,6,7,8,8-Octachloro-2,3,3a,4,7,7a-hexahydro-4,7-methano-1H-indene; 1 β, 2α, 4α, 5, 6, 7α, 8, 8-Octachloro-3a β,4,7,7a β-tetrahydro4,7-methanoindan; (±)-trans-Chlordane; trans-Chlordan; trans-1,2,4,5,6,7,8,8-Octachloro-3a,4,7,7a-tetrahydro-4,7-endo-methanoindan; trans-Chlordan; trans-Chlordane; β-Chlordan; β-Chlordane. Grades: Highly Purified. CAS No. 5103-74-2. Pack Sizes: 5mg. Molecular Formula: C10H6Cl8, Molecular Weight: 409.78. US Biological Life Sciences. | Worldwide |
| γ-L-Glutamyl-L-glutamic Acid 1-Benzyl 21,25-Dimethyl Triester Chloride | Protected γ-L-Glutamyl-L-glutamic Acid. A short peptide found in Lentinus edodes, asparagus shoot and tabacco cells. γ-L-Glutamyl-L-glutamic Acid is a partial agonist at the N-methyl-D-aspartate receptors in cultured cerebellar granule cells. A substrate for γ-glutamyl transpeptidase (γ-GTP). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| γ-Lindane-13C6 | γ-Lindane-13C6. Group: Biochemicals. Alternative Names: (1α,2α,3 β, 4α, 5α, 6 β)-1,2,3,4,5,6-Hexachlorocyclohexane-13C6; 1,2,3,4,5,6-Hexachlorocyclohexane-13C6; 666-13C6; Aalindan-13C6; Aficide-13C6; Agrocide-13C6; Agrocide III-13C6; Agrocide WP-13C6; Ameisenmittel Merck-13C6; Aparasin-13C6; Aphtiria-13C6; Aplidal-13C6; Arbitex-13C6; Arcotal S-13C6; BBH-13C6; BHC-13C6; BHC (insecticide)-13C6; Ben-Hex-13C6; Benhexol-13C6; Bentox 10-13C6; Benzene Hexachloride-13C6; Bercema-Spritz-Lindan 50-13C6; Bexol-13C6; Celanex-13C6; Chloresene-13C6; Codechine-13C6; DBH-13C6; Detmol Extract-13C6; Devoran; Dol Granule-13C6; Drilltox-Spezial Aglukon-13C6; ENT 7,796-13C6; Entomoxan-13C6; Esoderm-13C6; Fenoform Forte-13C6; Forst-Nexen-13C6; Gamacid-13C6; Gamacide-13C6; Gamacide 20-13C6; Gamene-13C6; Gamma Benzene Hexachloride-13C6; Gamma-HCH-13C6; Gammalin-13C6; Gammalin 20; Gammaterr-13C6; Gammaxene-13C6; Gammexane-13C6; Gamoline-13C6; Geobilan-13C6; Geolin G 3-13C6; Gexane-13C6; HCC-13C6; HCCH-13C6; HCH-13C6; HGI-13C6; Heclotox-13C6; Hexa-13C6; Hexachloran-13C6; Hexachlorane-13C6; Hexachlorocyclohexane-13C6; Hexatin-13C6; Hexaverm-13C6; Hexicide-13C6; Hexyclan-13C6; Hilbeech-13C6; Hortex-1. Grades: Highly Purified. CAS No. 201417-04-1. Pack Sizes: 1mg. Molecular Formula: 13C6H6Cl6, Molecular Weight: 296.79. US Biological Life Sciences. | Worldwide |
| γ-Lipoic Acid | γ-Lipoic Acid. Group: Biochemicals. Alternative Names: 6,8-Dimercaptooctanoic Acid; (±)-Dihydro-α-lipoic Acid; (±)-Dihydrolipoic Acid; DL-Dihydro-α-lipoic Acid; Dihydrolipoic Acid; Dihydrothioctic Acid; Reduced Lipoic Acid; Reduced Thioctic Acid; Dihydrothioctic Acid; dl-Dihydrolipoic Acid. Grades: Highly Purified. CAS No. 462-20-4. Pack Sizes: 500mg. Molecular Formula: C8H16O2S2, Molecular Weight: 208.34. US Biological Life Sciences. | Worldwide |
| γ - (Methylamino) benzenepropanol | γ - (Methylamino) benzenepropanol. Group: Biochemicals. Alternative Names: 3-Methylamino-3-phenyl-1-propanol. Grades: Highly Purified. CAS No. 69888-75-1. Pack Sizes: 250mg. Molecular Formula: C10H15NO, Molecular Weight: 165.23. US Biological Life Sciences. | Worldwide |
| (γR)-γ-Aminobenzenebutanoic Acid-d5 Hydrochloride | (γR)-γ-Aminobenzenebutanoic Acid-d5 Hydrochloride. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg. Molecular Formula: C10H9D5ClNO2, Molecular Weight: 220.71. US Biological Life Sciences. | Worldwide |
| (γR)-γ-Aminobenzenebutanoic Acid Hydrochloride | (γR)-γ-Aminobenzenebutanoic Acid Hydrochloride. Group: Biochemicals. Grades: Highly Purified. CAS No. 1010129-08-4. Pack Sizes: 25mg. Molecular Formula: C10H14lNO2, Molecular Weight: 215.68. US Biological Life Sciences. | Worldwide |
| ( γ R) - γ -Aminocyclohexane propanol | ( γ R) - γ -Aminocyclohexane propanol. Group: Biochemicals. Grades: Highly Purified. CAS No. 1269942-21-3. Pack Sizes: 10mg. Molecular Formula: C9H9NO, Molecular Weight: 157.25. US Biological Life Sciences. | Worldwide |
| gamma-Secretase Inhibitor XXV, FT-9 (2-[3- (3, 5-dichlorophenoxy) phenyl]propanoic Acid) | FT-9, a cell-permeable NSAID-like compound, is a partially selective gamma-Secretase Inhibitor in both microsomes and whole cells. Displays dose-dependent inhibition of the gamma-secretase cleavage of beta-Amyloid Precursor Protein (APP) and APLP2 with IC50 values against APP ICD (intracellular domain) and APLP2 ICD of 260uM, but there is a less potent effect on gamma-secretase processing of APLP1. The concentration of FT-9 required to cause a 2-fold increase in APP CTFs, 3.4 +/- 0.4uM, is significantly lower than that for APLP1 (25.7 +/- 8.9uM) (P = 0.001). For comparison, the concentration of another gamma-Secretase inhibitor compound E needed for a 2-fold increase in the magnitude of the CTF band signal is not significantly different, being 0.27nM for APP versus 0.24nM for APLP1. This is the first example that a GSI can preferentially target APP processing while sparing other gamma-substrates. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??Cl?O?. US Biological Life Sciences. | Worldwide |
| ( γ S) - γ -Aminocyclohexane propanol | ( γ S) - γ -Aminocyclohexane propanol. Group: Biochemicals. Grades: Highly Purified. CAS No. 1270271-76-5. Pack Sizes: 25mg. Molecular Formula: C9H9NO, Molecular Weight: 157.25. US Biological Life Sciences. | Worldwide |
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