USBiological 4 - Products
Worldwide
Our biochemicals, antibodies, recombinant proteins, cell culture media and molecular biology kits are used in virtually all scientific applications.From affordable research quantities to larger bulk amounts.
| Product | Description | |
|---|---|---|
| Mandelic Acid-13C6 | Mandelic Acid-13C6 is the labeled version of M162525 which is used as an antiseptic (urinary). It is also used as a short-term exposure biomarker in urine from styrene exposed workers. Group: Biochemicals. Grades: Highly Purified. CAS No. 153489-15-7. Pack Sizes: 1mg, 5mg. Molecular Formula: C213C6H8O3, Molecular Weight: 158.1. US Biological Life Sciences. |  Worldwide |
| Mannosylceramide, alpha | Natural killer T cells (NKT cells) are important regulators of the immune system. They share properties of both innate as well as adaptive immunity. They express T cell receptors (TCR) on their surface consisting of an invariable α-chain and a somewhat variable β-chain. The majority of NKT cells express the invariable α-chain Vα14-Jα18 (Vα14) in mouse or its homolog in humans Vα24-Jα18 (Vα24). Vα14 NKT cells recognize α-GalCer presented by CD1d. NKT cells expressing the invariant Vα19-Jα26 TCR α-chain (Vα19 NKT cells) have been found in peripheral blood lymphocytes and in the liver. They recognize α-ManCer presented by MR1 (Major histocompatibility complex, class I-related) and respond with production of large amounts of immunoregulatory cytokines. Group: Biochemicals. Alternative Names: α-ManCer; α-Mannosyl Ceramide; (2S,3S,4R)-2-Amino-N-hexacosanoyl-1-O-(α-D-mannopyranosyl)-1,3,4-octadecanetriol; α-D-Galactopyranoside. Grades: Highly Purified. CAS No. 320610-63-7. Pack Sizes: 250ug, 1mg. Molecular Formula: C50H99NO9. US Biological Life Sciences. | Worldwide |
| Manumycin A | Antibiotic. Potent, selective and competitive cell permeable rasfarnesyltransferase inhibitor (IC50= 30nM). Does not affect geranyl geranyl transferase (IC50=180uM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras. Neutral sphingomyelinase inhibitor. Blocks insulin-induced MAP kinase activation in rat cardiac myocytes (19uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 52665-74-4. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Manumycin A (NSC-622141, UFC 1C) | An antibiotic Isolated from Streptomyces parvulus. A Potent, selective and competitive cell permeable rasfarnesyltransferase (FTase) inhibitor (IC50 = 30nM). Does not affect geranyl geranyl transferase (GGTase) (IC50 = 180uM). Blocks insulin-induced MAP kinase activation in rat cardiac myocytes (19uM).uM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras. Group: Biochemicals. Grades: Highly Purified. CAS No. 52665-74-4. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Manumycin B | Antibiotic and antibacterial. Active against Gram-positive bacteria. Rasfarnesyltransferase and apoptosis (Caspase-1) inhibitor. AChE inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 139023-58-8. Pack Sizes: 1mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| MARK/Par-1 Activity Inhibitor, 39621 (N-(2,5-Dimethylphenyl)-2-(4-(4-methoxyphenyl)-3-oxo-3,4-dihydropyrazin-2-ylthio)acetamide, Microtubule Affinity Regulating Kinase Inhibitor, MAP Affinity Regulating Kinase Inhibitor, PAR1 Inhibitor) | A cell-permeable dihydropyrazinyl-thioacetamide that acts as an ATP-competitive MARK-selective inhibitor (IC50=3.6uM; [ATP]=100uM). Shown to effectively block primary rat cortical neuron axon growth (5.7um/hr vs 32.5um/hr with or without 20uM inhibitor) and prevent MARK2 overexpression-induced Tau Ser262 phosphorylation and cytotoxicity in CHO cells (10uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MAT2A Inhibitor II, FIDAS-5 | A cell-permeable fluorinated N,N-dialkylaminostilbene (FIDAS) analogue of FIDAS-3 that competes against SAM for MAT2A binding and is >2-fold more potent than FIDAS-3 in inhibiting MAT2A-catalyzed SAM synthesis both in cell-free assays (IC50 = 2.1uM) and in LS174T colorectal cancer (CRC) cultures (3uM). FIDAS-5 at 3uM is shown to completely inhibit the proliferation of LS174T for up to 7 d in vitro and effectively suppress HT29 CRC tumor expansion in mice in vivo (20mg/kg/day p.o.). Group: Biochemicals. Alternative Names: FIDAS5; Methionine S-Adenosyltransferase 2A Inhibitor II; (E)-4-(2-Chloro-6-fluorostyryl)-N-methylaniline. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C15H13CIFN, Molecular Weight: 261.73. US Biological Life Sciences. | Worldwide |
| Maytansinoid DM4 | Maytansinoid DM4 is a cytotoxic agent. It is used as a antibody-drug conjugate that has a potential to treat cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 799840-96-3. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C39H56ClN3O10S, Molecular Weight: 794.39. US Biological Life Sciences. | Worldwide |
| Mcl-1 Inhibitor, MIM1 (4-((E)-((Z)-2-(cyclohexylimino)-4-methylthiazol-3(2H)-ylimino)methyl)benzene-1,2,3-triol, Mcl-1 Inhibitor Molecule 1) | A cell-permeable thiazolyl iminopyrogallol that selectively neutralizes Mcl-1, but not Bcl-XL, antiapoptotic activity by directly targeting Mcl-1 BH3-binding site, effectively competing against Bid BH3 sequence for Mcl-1 binding (IC50 = 4.8uM). Shown to induce caspase 3/7 activation and cell death in Mcl-1-, but not Bcl-XL-, dependent B-ALL cultures (6% vs. 82% survival, respectively; 10uM). In comparison, ABT-737 affects only Bcl-XL-, but not Mcl-1-, dependent B-ALL cells. Neither MIM1 nor ABT-737 significantly affects the survival of wild-type or Bax-/-Bak-/- MEF. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
| MDL 28170, Z-Val-Phe-CHO, (Carbobenzoxy-valinyl-phenylalaninal, Calpain Inhibitor III) | A potent, cell-permeable, and selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25nm respectively). MDL 28170 does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo. Modulates the formation of Ab formation by inhibiting the formation of intermediate Ab46 and protecting Ab from degradation. Group: Biochemicals. Grades: Highly Purified. CAS No. 88191-84-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MDM2 Antagonist IV, Nutlin-3a ((-)-4-(4,5-bis-(4-Chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazole-1-carbonyl)piperazine-2-one) | A cell-permeable and highly potent active enantiomer of Nutlin-3 that binds to the p53-binding pocket and blocks the interaction of p53 and MDM2 (IC50=90nM). Exhibits over 150-fold greater affinity for MDM2 than its less active enantiomer, Nutlin-3b. Induces p53 mediated apoptosis by both transcription-dependent and independent mechanisms. Shown to greatly potentiate the cytotoxic effects of chemotherapeutic agents and reduce tumor burden in vivo. Also shown to overcome ATM-mediated resistance to fludarabine in chronic lymphocyte leukemia. Cells treated with Nutlin-3a permanently lose their ability to proliferate and enter into a pattern of permanent senescence. Mouse embryonic fibroblasts with p53+/+ MEFs show significantly reduced reprogramming capabilities following Nutlin-3a treatment. Group: Biochemicals. Grades: Highly Purified. CAS No. 675576-98-4. Pack Sizes: 5mg. Molecular Formula: C??H??Cl?N?O?. US Biological Life Sciences. | Worldwide |
| MDM2 Inhibitor VII, MEL23 (3-Butyl-6-hydroxy-5-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)pyrimidine-2,4(1H,3H)-dione, MDM2-MDMX E3 Ligase Inhibitor) | A cell-permeable tetrahydro-b-carbolinylbarbiturate compound that selectively inhibits the E3 ligase activity of Mdm2-MdmX hetero-complex over that of Mdm2-Mdm2 homo-complex (70.6% vs. 17.6% inhibition, respectively, at 100uM), without affecting Mdm2-MdmX complex formation or the activity of two other UbcH5C-utilizing ligase complexes Roc1-Cul1 and BRCA1-BARD1. Effectively inhibits ubiquitination and proteasomal degradation of cellular Mdm2 and p53 (effective conc.=14uM in U2OS, RKO, and HCT116 cultures) and induce RKO and MEF cell death in a p53- and Mdm2-dependent manner. Unlike Nutlin-3, MEL23 does not interfere with Mdm2-p53 interaction. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MDM2/MDMX Dual Inhibitor, RO-5963 ((Z)-2-(4-((6-Chloro-7-methyl-1H-indol-3-yl)methylene)-2,5-dioxoimidazolidin-1-yl)-2-(3,4-difluorophenyl)-N-(1,3-dihydroxypropan-2-yl)acetamide, MDM2 Inhibitor VII, MDMX Inhibitor III) | A cell-permeable indolyl-hydantoin compound that simultaneously inhibits the interaction of both, MDM2 and MDMX with p53 (IC50 = 17.3 and 24.7nM, respectively, in vitro). Releases p53 from MDMX inhibition, stabilizes it, and fully restores its function. Shown to be far more superior to Nutlin-3a in blocking p53 interaction with MDMX. Binds to Phe, Trp, and Leu sub-pockets on the surface of MDMX and MDM2, and promotes MDMX and MDM2 dimer formation. Shown to induce cell cycle arrest in G1 and G2 phases. Also reported to induce apoptosis in several tumor cell lines expressing wild-type p53/MDMX (~10-20uM). Its actions are not believed to be due to any genotoxic stress. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MDMA (Methylenedioxy-N-methylamphetamine (MDMA) (Ecstacy) (BSA) | Methylenedioxy-N-methylamphetamine (MDMA). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Mecamylamine Hydrochloride (N, 2, 3, 3-Tetramethylbicyclo[2. 2. 1]he-ptan-2-amine hydrochloride, TC-5214, Inversine, nAChR Antagonist, Mecamylamine Hydrochloride) | A potent, nonselective, and noncompetitive antagonist of nAChRs (IC50 = 640nM, 2.5uM, 3.6uM and 6.9uM for alpha3beta4, alpha4beta2, alpha3beta2 and alpha7 subtype nAChRs, respectively). Biologically viable admitted orally or systematically. Widely used in investigating the roles of central nAChRs in the brain functions (learning and memory, decision making, cognition) and disorders (addiction, Autisms, Tourette's syndrome, Schizophrenia and various cognitive and mood disorders). Group: Biochemicals. Grades: Highly Purified. CAS No. 826-39-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Menin-MLL Interaction Inhibitor, MI-2-2 (MI22, 4- (4- (5, 5-Dimethyl-4, 5-dihydrothiazol-2-yl) piperazin-1-yl) -6- (2, 2, 2-trifluoroethyl) thieno[2, 3-d]pyrimidine, HCl) | A cell-permeable thienopyrimidine compound that competes against MLL (Mixed Lineage Leukemia) for menin binding (IC50 = 46 and 520nM, respectively, against MBM1 sequence MLL4-15 and MLL4-43 containing both MBM1 & MBM2) by targeting menin MLL-binding pocket with high affinity (KD = 22nM), effectively disrupting cellular menin and MLL-AF9 fusion interaction (by >90% at 12uM in MLL-AF9-expressing HEK293 cells). Shown to inhibit the oncogenic proliferation of four MLL translocation-harboring human leukemia cell lines (by >95% in 12 d at 6uM), but not non-MLL leukemia Kasumi-1 and HAL-01 lines (≤16% inhibition at 12uM), by downregulating MLL target genes expression via simultaneous hematopoietic differentiation induction and killing of non-differentiated population. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Mensacarcin | Antibiotic. Antitumor compound. Cytotoxic. Group: Biochemicals. Grades: Highly Purified. CAS No. 808750-39-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C21H24O9. US Biological Life Sciences. | Worldwide |
| Menthol-D4 | Deuterium labelled analog of Menthol, which is used as: refreshing agent, food flavor, cool and antipruritic drug, carminative drug. Menthol crystals is used for personal care and cosmetics. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C10H16D4O, Molecular Weight: 160.29. US Biological Life Sciences. | Worldwide |
| Mer RTK Inhibitor, UNC569 (1- ( (trans-4-Aminocyclohexyl) methyl) -N-butyl-3- (4-fluorophenyl) -1H-pyrazolo[3, 4-d]pyrimidin-6-amine, MERTK Inhibitor I, RP38 Inhibitor I, TAM Family RTK Inhibitor I) | An orally bioavailable pyrazolopyrimidine compound that acts as a potent, reversible and ATP-competitive inhibitor of Mer receptor tyrosine kinase (IC50=2.9nM; Ki=4.3nM) with ~10-fold greater selectivity over other TAM family kinases (IC50=37 and 48nM for Axl and Tyro3, respectively). Also shown to affect the activities of Flt3, MAPKAPK2, RET and Ret-Y791F at 30nM by 82%, 92%, 59% and 56% in a 72 kinase panel, and block Mer auto-phosphorylation in human Pre-B leukemia 697 cells with an IC50 of 141nM. Exhibits desirable pharmacokinetic profile and efficacy in mice. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Mesitylene-13C3 | Mesitylene-13C3 is labelled Mesitylene (M258390) which is a precursor to diverse fine chemicals. It is also commonly used as a solvent in the laboratory. Group: Biochemicals. Grades: Highly Purified. CAS No. 112274-95-0. Pack Sizes: 1mg, 5mg. Molecular Formula: C613C3H12, Molecular Weight: 123.17. US Biological Life Sciences. | Worldwide |
| Mesothelin, Positive Control (MSLN, SMR, MPF, CAK1) | Mesothelin, Positive Control (MSLN, SMR, MPF, CAK1). Group: Molecular Biology. Pack Sizes: 15ul. US Biological Life Sciences. | Worldwide |
| Methamphetamine (Methamphetamine-BSA Hapten) (BSA) | Methamphetamine is a psychostimulant of the phenethylamine and amphetamine class of drugs. It increases alertness, concentration, energy, and in high doses, can induce euphoria, enhance self-esteem, and increase libido. Methamphetamine has high potential for abuse and addiction by activating the psychological reward system via triggering a cascading release of dopamine, norepinephrine and serotonin in the brain. Group: Biochemicals. Grades: Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Methamphetamine-S (HRP) | Methamphetamine (METH) is closely related chemically to amphetamine (AMPH). METH is a potent central nervous system stimulant with additional peripheral sympathomimetic effects. METH and AMPH have been used clinically in the treatment of obesity, minimal brain dysfunction, narcolepsy, depression and to counter fatigue. They are also subjected to widespread abuse. METH is an indirect agonists. It causes the release of newly synthesized norepinephrine and dopamine and it blocks the re uptake of these transmitters from the synapse. This can lead to an increase in the concentration of catecholamines in the synapse as well as an overall increase in catecholaminergic activity in the brain. The mechanism of METH induced neurotoxicity for all monoaminergic cell types may lie primarily with the dopaminergic system in the striatum. It may also lie with the interaction between METH induced release of dopamine and its ability to inhibit monoamine oxidase. Group: Biochemicals. Grades: Purified. Pack Sizes: 1ml. US Biological Life Sciences. | Worldwide |
| Methanol-13C | Assignments of far-IR (FIR) laser lines have been found for optically pumped Methanol-13C. Group: Biochemicals. Grades: Highly Purified. CAS No. 14742-26-8. Pack Sizes: 1g, 5g. Molecular Formula: 13CH4O. US Biological Life Sciences. | Worldwide |
| Methyl 1-Testosterone | Methyl-1-Testosterone is a derivative of dihydrotestosterone. Methyl-1-Testosterone is a designer anabolic steroid that is on the world anti-doping agencyÂs (WADA) prohibited list. Group: Biochemicals. Grades: Highly Purified. CAS No. 65-04-3. Pack Sizes: 25mg, 100mg. Molecular Formula: C20H30O2. US Biological Life Sciences. | Worldwide |
| Methyl-(2R)-2-hydroxy-3-phenylpropanoate | Methyl-(2R)-2-hydroxy-3-phenylpropanoate. Group: Biochemicals. Grades: Highly Purified. CAS No. 27000-00-6. Pack Sizes: 100mg, 250mg. Molecular Formula: C10H12O3, Molecular Weight: 180.2. US Biological Life Sciences. | Worldwide |
| Methyl 4-(Methylamino)benzoate | Methyl 4-(Methylamino)benzoate is used as a reagent in the synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5. Also used in the preparation of hyaluronic acid-methotrexate conjugates as antiarthritic and antiinflammatory agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 18358-63-9. Pack Sizes: 250mg, 500mg. Molecular Formula: C9H11NO2, Molecular Weight: 165.19. US Biological Life Sciences. | Worldwide |
| Methyl 9-Oxononanoate (90%) | Methyl 9-Oxononanoate is a linseed oil-based coating. It is solventless polymeric protective. Group: Biochemicals. Grades: Highly Purified. CAS No. 1931-63-1. Pack Sizes: 100mg, 250mg. Molecular Formula: C10H18O3. US Biological Life Sciences. | Worldwide |
| Methyl Cellulose(350-550mPa.s, 2% in Water at 20deg C) | Methyl Cellulose(350-550mPa.s, 2% in Water at 20deg C). Group: Molecular Biology. CAS No. 9004-67-5. Pack Sizes: 25g, 500g. US Biological Life Sciences. | Worldwide |
| Methylene blue | Methylene blue is a polyaromatic stain. Group: Biochemicals. Grades: Highly Purified. CAS No. 61-73-4. Pack Sizes: 10g, 25g. Molecular Formula: C16H18N3S Cl, Molecular Weight: 284.403545. US Biological Life Sciences. | Worldwide |
| Methyl Heptadecanoate | Methyl heptadecanoate is used in biological studies for the formation of beef flavor precursors and its correlation with chemical parameters during the controlled thermal oxidation of tallow. Group: Biochemicals. Grades: Highly Purified. CAS No. 1731-92-6. Pack Sizes: 1g, 10 g. Molecular Formula: C18H36O2. US Biological Life Sciences. | Worldwide |
| Methyl Linoleate-d3 | Methyl Linoleate-d3 is labelled Methyl Linoleate (M265190) which is a common methyl ester produced from soybean or canola oil and methanol. Methyl Linoleate is classified as a biodiesel due to its long methyl ester chain and is used as a fuel in standard diesel engines. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 100mg. Molecular Formula: C19H31D3O2, Molecular Weight: 297.49. US Biological Life Sciences. | Worldwide |
| Methylphosphonic Dichloride | Methylphosphonic Dichloride is an intermediate in synthesizing O,S-Diethyl Methylphosphonothioate (D444460), an inhibitor of cholinesterase. Group: Biochemicals. Grades: Highly Purified. CAS No. 676-97-1. Pack Sizes: 5g, 25g. Molecular Formula: CH3Cl2OP. US Biological Life Sciences. | Worldwide |
| Methysergide Maleate (5-HT Serotonin Receptor Antagonsit, Methysergide Maleate, UML-491) | An antagonist of the 5-HT2B (pki = 8.0-9.4) and 5-HT2C (pki = 8.6-9.1) receptor. At the 5-HT1A and some other 5-HT receptors it serves as a partial agonist. It is known to have partial agonist effects on other 5-HT receptors as well. In neuronal and platelet culture, Methysergide blocks serotonin action with an IC50 = 18uM. Originally developed in the 1960?s as a migraine/cluster headache treatment, but discontinued due to significant physiological and pyschotropic side effects. Methysergide is still actively used in research as a 5-HT2 receptor antagonist in both in vivo and in vitro experiments. Group: Biochemicals. Grades: Highly Purified. CAS No. 129-49-7. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?·C?H?O?. US Biological Life Sciences. | Worldwide |
| Mexiletine Dimer | Mexiletine Dimer is an impurity compound of Mexiletine (M340800), an antiarrhythmic (class IB). Group: Biochemicals. Grades: Highly Purified. CAS No. 2059988-38-2. Pack Sizes: 25mg, 100mg. Molecular Formula: C22H32N2O2, Molecular Weight: 356.5. US Biological Life Sciences. | Worldwide |
| Midkine Inhibitor, iMDK (MDK Expression Inhibitor, 3- (2- (4-Fluorobenzyl) imidazo[2, 1-b]thiazol-6-yl) -2H-chromen-2-one, 3- (2- (4-Fluorobenzyl) imidazo[2, 1-b][1, 3]thiazol-6-yl) -2H-chromen-2-one) | A cell-permeable imidazothiazolyl-chromenone compound that reduces cellular midkine/MDK protein level in H441 lung adenocarcinoma cells in a dose-dependent manner (by >90% in 48h at 25nM) via a yet unidentified mechanism. Shown to inhibit the viability of MDK-positive HEK293, H441, and H520 cells (by ≥60% at 500nM in 48h), but not MDK-negative NHLF or HEK293 (by <15% at 500nM in 48h), via apoptosis induction as a result of PI 3-K/AKT signaling inhibition. Intraperitoneal injection is reported to be efficacious in retarding H441 tumor expansion in mice (9mg/kg; 3X to 5X per wk) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??FN?O?S. US Biological Life Sciences. | Worldwide |
| MIF Antagonist IV, RDR 03785 (Macrophage Migration Inhibitory Factor Antagonist IV, 6- (Morpholino (4- (trifluoromethyl) phenyl) methyl) -1, 3-benzodioxol-5-ol) | A cell-permeable morpholino-benzodioxol compound that inhibits MIF tautomerase activity (Ki and IC50 = 0.57 and 2.4uM, respectively) via direct non-covalent MIF interaction ( = 24.5uM). RDR 03758 at 10uM is shown to completely neutralize the overriding effect of 100ng/ml MIF on the inhibition of LPS-stimulated TNF production by dexamethasone in RAW 264.7 marcophage cultures. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MIF antagonist, p425 (Chicago Sky blue 6B, 6,6'-[(3,3-Dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxy-1,3-napthalenedisulphonic acid] tetrasodium salt) | A counterstain for background autofluorescence in fluorescence and immunofluorescence histochemistry. Acts as an allosteric MIF (macrophage migration inhibitory factor) inhibitor. It occupies an interface of MIF trimers, leading to the loss of its tautomerase, receptor binding, and pro-inflammatory activities. An excellent tool to design MIF-directed therapeutics for inflammatory diseases. Group: Biochemicals. Grades: Purified. CAS No. 2610-5-1. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| MIF Antagonist V, p425 (Sodium 6,6-(1E,1E)-(3,3-dimethoxybiphenyl-4,4-diyl)bis(diazene-2,1-diyl)bis(4-amino-5-hydroxynaphthalene-1,3-disulfonate)) | A symmetrical bis-(amino, hydroxynaphthalene disulfonate) compound that antagonizes macrophage migration inhibitory factor against receptor binding (IC50=810nM against hMIF and CD74 interaction) and is more potent than ISO-1 in suppressing MIF-induced cytokines and MMP-3 productions in human fibroblasts cultures (IC50= <0.7uM vs>5uM). Unlike MIF Antagonists I-IV, p425 targets an area at the interface of two MIF trimers, distal to the active site. Group: Biochemicals. Grades: Highly Purified. CAS No. 2610-5-1. Pack Sizes: 2g. US Biological Life Sciences. | Worldwide |
| Miglitol (BAY-1099) | An a-glucosidase inhibitor which induces an enhanced and prolonged release of glucagon-like peptide-1, regulating appetite and stabilizing body weight in humans. Displays anti-atherothrombotic effect by reducing platelet activation and raising circulating adiponectin levels in patients with type 2 diabetes. Clinically useful antidiabetic agent. Group: Biochemicals. Alternative Names: (2R, 3R, 4R, 5S) -1- (2-Hydroxyethyl) -2- (- (hydroxymethyl) piperidine-3, 4, 5-triol, N-(2-Hydroxyethyl)-1-deoxynojirimycin. Grades: Highly Purified. CAS No. 72432-03-2. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Milrinone (1, 6- dihydro- 2- methyl- 6- oxo- [3, 4'- bipyridine]- 5- carbonitrile, WIN 47, 203) | Cell-permeable. A potent, cAMP-specific phosphodiesterase (PDEIII ) inhibitor (IC?? = 0.45 and 1.0um for PDEIIIA and PDEIIIB, respectively). It inhibits other PDE isoforms at much higher concentrations. Milrinone has positive inotropic (stimulates cardiac muscle contractions) and vasodilatory effects when administered in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 78415-72-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| MIM1 (4-(E)-[[(2Z)-2-cyclohexylimino)-4-m ethyl-1, 3-thiazol-3 (2H) -yl] imino] methyl] benzene-1, 2,3-triol) | MIM1 (4-(E)-[[(2Z)-2-cyclohexylimino)-4-m ethyl-1, 3-thiazol-3 (2H) -yl] imino] methyl] benzene-1, 2,3-triol). Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. Molecular Formula: C17H21N3O3S, Biological Activity: Inhibitor of Mcl-1; selectively targets the BH3-binding pocket. Induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells. Also blocks Mcl-1-mediated suppression of tBID-induced Bax activation in vitro. US Biological Life Sciences. | Worldwide |
| Minoxidil β-D-Glucuronide Methyl Ester | Minoxidil β-D-Glucuronide Methyl Ester is an glucuronide intermediate in the synthesis of Minoxidil (M345000) metabolites. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C16H25N5O7. US Biological Life Sciences. | Worldwide |
| Mirk/Dyrk1B Inhibitor, Compound A (N- (2-Chloro-5- (3-chlorobenzylcarbamoyl) phenyl) -2-methoxy-7-oxo-7, 8-dihydropyrido[2, 3-d]pyrimidine-6-carboxamide, N- (2-Chloro-5- ( (3-chlorobenzyl) carbamoyl) phenyl) -7-hydroxy-2-methoxypyrido[2, 3-d]pyrimidine-6-carboxamide) | A cell-permeable di hydropyridopyrimidine-carboxamide compound that acts as a potent and reversible inhibitor of Mirk/Dyrk1B and Dyrk1A kinases (IC50 = 68 and 22nM). Exhibits very high selectivity for Mirk/Dyrk1B compared to Abl, Flt3, and MARK1 (64, 56 and 73% inhibition at 10uM, respectively) and a panel of 46 other kinases. Shown to induce activation of caspase-3 and sensitize tumor cells to the action of gemcitabine and cisplatin, possibly by de-stabilizing p27. Preferentially increases cycling in Mirk-elevated quiescent pancreatic cancer cells (SU86.86, Panc1, AsPc1, and SW620 at ~1uM). Also, shown to increase level of superoxides in quiescent pancreatic tumor cells (Panc1, SU86.86, and AsPc1) by blocking SOD2 and SOD3 activities. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MitoBloCK-6 (2- ( ( (4-Anilinophenyl) imino) methyl) -4, 6-dichlorophenol, 2, 4-Dichloro-6- ( ( ( ( (phenylamino) phenyl) imino) methyl) phenol) , Mitochondrial Protein Import Blocker from the Carla Koehler Laboratory, MB6, MB-6) | A cell-permeable, stable dichlorosalicylalde hyde Schiff's base that acts as a potent, selective inhibitor of Mia40/Erv1 redox-mediated import pathway (IC50 = 700nM, 900nM, and 1.4uM for ALR, Erv1, and Erv2, respectively). Significantly reduces the import of CX9 proteins, Erv1, Tim23, and ADP/ATP carrier (AAC). However, it does not affect mitochondrial membrane integrity as evidenced by the lack of aconitase, AAC, Tim54, Mia40, and cytochrome c release. Has no effect on protein disulfide isomerase, flavin adenine dinucleotide, and succinate dehydrogenase activities and does not disrupt mitochondrial net work or reduce viability of cells even at high concentrations (~100uM in HeLa and HEK293 cells). Reported to specifically cause cytochrome c release, activate caspase-3, and induce apoptosis in human embryonic stem cells (~20uM), but not in differentiated cells. Reversibly impairs cardiac development and reduces heart rate in zebra fish that is attributed to mitochondrial dysfunction. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??Cl?N?O, Primary Target: Erv1. US Biological Life Sciences. | Worldwide |
| Mitochondrial ATF Translocator, SBI-0087702 (N- ( (4-methoxynaphthalen-1-yl) methyl) -2- (4-methoxyphenyl) ethanamine, SBI0087702, SBI 0087702) | A cell permeable naphthalene derivative that promotes the translocation of ATF2 from nucleus to mitochondria via PKCe that results in mitochondrial membrane leakage and cell death in melanoma cells (WM793 and UACC903). Diminishes cell motility and anchorage-free growth in melanoma cells (<90% at 10uM) and reduces their migration in an ATF2-dependent manner. Shown to reduce ATF2 phosphorylation on Thr52, 69, and 71. However, it does not affect the activity of Erk1/2, Akt, pan-PKC. Cells expressing ATF2T52E do not exhibit any loss of mitochondrial membrane potential. Does not induce apoptosis in normal melanocytes even at high concentrations (~20 mM) and has no effect on the localization or translocation of p53, STAT3, or b-catenin. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Mitochondrial Fusion Promoter, M1 ( (E) -4-Chloro-2- (1- (2- (2, 4, 6-trichlorophenyl) hydrazono) ethyl) phenol) | A cell-permeable phenylhydrazone that restores mitochondrial tubular network formation in MEF lacking either of the two outer mitochondrial membrane (OMM) mitofusins (EC50=5.3 and 4.42 mM, respectively, in Mfn1 or Mfn2 knockout MEF cells) or in MPP+-treated SH-SY5Y cells (5uM 24h), but not in MEF lacking both Mfn1/2 or the inner mitochondrial membrane (IMM) fusion mediator Opa1 (optic atrophy1). M1 (5uM 24h) is reported to boost the downregulated ATP5A & ATP5B protein level in Mfn1 or Mfn2 knockout MEF to the wild-type MEF level and ATPase inhibitor oligomycin at 5uM is shown to completely offset the mitochondrial fusion effect by 5uM M1 in Mfn1 knockout MEF. Comparing to mdivi-1, M1 exerts its effect via promoting fusion rather than inhibiting fission or division. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Mitochondrial Pyruvate Carrier Inhibitor, UK5099 ((E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)acrylic acid, (E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid, MPC Inhibitor, PF-1005023) | A cell-permeable alpha-cyanocinnamate compound that acts as a rapid, active site thiol modifying, time-dependent and non-competitive inhibitor of bi-directional pyruvate transport across plasma membranes in yeast, bacteria, Drosophila, and humans (IC50 = 50nM in rat heart mitochondria; Ki ≤1uM) with excellent selectivity over monocarboxylates and anions. Shown to significantly decrease pyruvate-driven respiration, enhance glucose uptake and activate AMPK (2uM in human myocytes and skeletal muscle myotubes). Group: Biochemicals. Grades: Highly Purified. CAS No. 56396-35-1. Pack Sizes: 5mg, 25mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| mitoNEET Inhibitor NL-1, Thiazolidinedione (5-(3,5-di-tert-butyl-4-hydroxybenzyl)-4-hydroxythiazol-2(5H)-one) | A cell-permeable, thiazolidinedione (TZD) that acts as an inhibitor of MitoNEET (IC50=0.9uM) in competition with rosiglitazone and pioglitazone, in liver mitochondrial suspensions. In pharmacological studies, it was found to alter isolated mitochondrial complex I respiration with an IC50 of 2.4uM and inhibited State III respiration up to 45%. Furthermore, this compound (6-25uM) is shown to dose-dependently reduce lactate-dehydrogenase release in SH-SY5Y cultures, leading to a 40% decrease in rotenone-induced cell-death. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MK-2 Inhibitor IV, MK-25 (MAPKAP-K2 Inhibitor IV, MK-25, 5-(4-Chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamide, HCl) | A cell-permeable furanylcarboxamide compound that acts as a potent, reversible and non-ATP-competitive inhibitor of MK-2/MAPKAP-K2 activity (IC50=110nM; EC50=350nM for pHSP27 in IL-1b-stimulated SW1353 cells) with excellent selectivity over 150 kinases (% activity inhibition at 10uM against human CK2, Haspin, Arg and CK1y3=40, 40, 42 and >70, respectively). Shown to efficiently suppress the secretions of TNFa, IL6 (IC50=4.4 and 5.2uM in LPS-stimulated THP1 cell, respectively) and MMP-13 (IC50=5.7 and 2.2uM in IL1b-stimulated SW1353 and in primary osteoarthritis-derived chondrocytes, respectively). Exhibits desirable bioavailability and weakly inhibits a panel of cytochrome P450 isozymes (IC50>20uM for 3A4, 2D6 and 2C9). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ML243 (Cancer Stem Cell Inhibitor, ML243, (E) -N- (4, 5-Dihydrothiazol-2-yl) -3- (4-ethylphenyl) acrylamide, (2E)-N-(4,5-Dihydro-1,3-thiazol-2-yl)-3-(4-ethylphenyl)prop-2-enamide) | A cell-permeable, biologically stable, 4-ethyl substituted cinnamide analog that selectively exerts an inhibitory effect on breast cancer stem-like cells (EC50 = 2uM for epithelial-to-mesenchymal transition; HMLE_shEcad). Exhibits ~32-fold greater selectivity over isogenic control cells (EC50 = 64uM; HMLE cell line expressing shRNA against eGFPcells; HMLE_sh_eGFP). Displays desirable aqueous solubility (~11.5uM in PBS, pH 7.4) and excellent stability in human plasma and in glutathione solution. Shown to block the binding to a radio-labeled ligand to the Adenosine A2A Receptor (IC50 = 10uM), but does not affect 68 other targets studied. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| MLKL Inhibitor, Necrosulfonamide ((E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide, Mixed Lineage Kinase Domain-like Protein Inhibitor, Necrosome Inhibitor II, Necrosulfonamide) | A cell-permeable acrylamide compound that inhibits human, but not murine, MLKL adaptor function via covalent modification of Cys86 and is more potent than Nec-1 in preventing necrotic/necroptotic death in human HT-29 (IC50 = 124nM and 2uM, respectively), being ineffective against necrosis/necroptosis in murine L929 or apoptosis in human RIP3-null Panc-1 cells. Unlike Nec-1, which prevents necrosome formation by blocking RIP1-RIP3 interaction, MLKL prevents the MLKL-RIP1-RIP3 necrosome complex from interacting with further downstream effectors. Group: Biochemicals. Grades: Highly Purified. CAS No. 432531-71-0. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?S?, Primary Target: human MLKL. US Biological Life Sciences. | Worldwide |
| MM 47755 (6-Desoxy-8-O-methylrabelomycin; (R)-3-Hydroxy-8-methoxy-3-methyl-3,4-dihydro-tetraphene-1,7,12(2H)-trione) | Antibiotic. Angucyclinone. Antibacterial and antifungal. Group: Biochemicals. Grades: Highly Purified. CAS No. 117620-87-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| MMP-2 Inhibitor IV (Bone Resorption Inhibitor, (4'-chlorobiphenyl-4ylsulfonamido) methylenediphosphonic Acid) | A cell-permeable, bisphosphonate derivative that displays nanomolar activity against MMP-2 (IC50=37nM), with good selectivity over MMP-8 (320nM), MMP-9 (>1uM), and MMP-14 (> 1uM). It is shown to inhibit osteoclast activity in a macrophage cell line, J774 (IC50=1.7uM), which is more potent compared with other bisphosphonates such as Alendronate, (IC50=30uM), and Zolendronate (7.8uM), without observable cytotoxicity in HepG2 cells. At 25uM, it abolishes the formation of actin rings, which are functional structures that are typical of resorbing osteoclasts, at activity levels comparable with those of zolendronic acid, inhibits bone resportion in vitro, and demonstrates cytotoxic properties in murine osteoclasts. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MMP-9 Inhibitor II (MMP-9 PEX Inhibitor) | This compound is a cell-permeable, selective, and reversible thiopyrimidone MMP-9 allosteric inhibitor that binds specifically to the non-catalytic site of MMP-9 at the PEX domain with a =2.1uM and thereby disrupts MMP-9 homodimerization and its cross-talk with CD44 and the EGFR-MAPK signaling pathway. It does not bind to the PEX domain of MMP-2 or MT1-MMP and it is shown to decrease MMP-9 mediated cell migration in COS-1 cells at 100uM. Also, it inhibits cell migration and invasion of HT-1080 and MDA-MB-435 human cancer cells in a dose-dependent manner from 0.1 to 100M, without altering MMP-9 expression or proteolytic activity in HT-1080 cells. In addition, it attenuates both primary tumor growth and metastasis in vivo in a mouse model without obvious toxicity (20mg/kg, 6 days/week, i.v. and i.t.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MMPIP (6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[ 4,5-c]pyridin-4(5H)-one) | A potent negative allosteric modulator highly selective for mGlu7 receptors (IC50 = 15nM). No effect on other subtype mGlu receptors. Frequently used in studies of alcohol and cocaine addition, depression, anxiety and stress related disorders. Group: Biochemicals. Grades: Highly Purified. CAS No. 479077-02-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| MNK1/2 Inhibitor II, ETP-45835 (ETP45835?MNK Inhibitor II, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor II) (4-(3-(Piperidin-4-yl)-1H-pyrazol-5-yl)pyridine, diHCl) | A cell-permeable 3,5-disubstituted pyrazolo compound that acts as a selective MNK inhibitor (IC50=646 and 575nM, respectively, against MNK1 and MNK2) with much reduced or little activity against 24 other kinases (<15% inhibition at 5uM). Reported to exhibit good aqueous solubility (>100uM at pH 7.4) and inhibit the proliferation (IC50=17uM) and cellular eIF4E Ser209 phosphorylation (IC50=4.7uM) of MV4:11 cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N? 2HCl. US Biological Life Sciences. | Worldwide |
| Moclobemide N-Oxide | Moclobemide N-Oxide is a metabolite of Moclobemide (M481000), a reversible monoamine oxidase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 64544-24-7. Pack Sizes: 10mg, 100mg. Molecular Formula: C13H17ClN2O3. US Biological Life Sciences. | Worldwide |
| Mor-DalPhos | Mor-DalPhos is a versatile and efficient green catalytic system for Buchwald-Hartwig cross-coupling reaction of aryl bromides or chlorides with a large set amines, amides, ureas, and carbamates. Group: Biochemicals. Grades: Highly Purified. CAS No. 1237588-12-3. Pack Sizes: 50mg, 100mg. Molecular Formula: C30H42NOP, Molecular Weight: 463.63. US Biological Life Sciences. | Worldwide |
| MPEP Hydrochloride (6-Methyl-2- (phenylethynyl) pyridine Hydrochloride) | A non-competitive, highly potent antagonist selective for mGlu5 receptors (IC50 = 36nM). Also a positive allosteric modulator of mGlu4 and weak anatagonist of nMDA receptors. Biologically active admitted systematically. Widely used in assessing the functional roles of mGlu5 receptors in a variety of research areas, such as learning and memory, sleep, neuroprotection, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson's disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 96206-92-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MPLA (Synthetic) Sterile Solution (Monophosphoryl Lipid A, Phosphorylated Hexaacyl Disaccharide, Glycopyranoside Lipid A, Glucopyranosyl Lipid Adjuvant, GLA) | Toll-like receptor 4 (TLR4) activator. Activates TLR4 but does not activate TLR2 even at high concentrations. Defined structure of MPLA. Synthetic lipid A is structurally very similar to natural MPLA but does not exist in nature. Group: Biochemicals. Grades: Cell Culture Grade. CAS No. 1246298-63-4. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| MPS1 Inhibitor, NMS-P715 ( (N- (2, 6-diethylphenyl) -1-methyl-8- ({4-[ (1-methylpiperidin-4-yl) carbamoyl]-2- (trifluoromethoxy) phenyl}amino) -4, 5-dihydro-1H-pyrazolo[4, 3-h]quinazoline-3-carboxamide) ) | An orally bioavailable, ATP-competitive, pyrazolo-quinazoline, MPS1 inhibitor (IC50=182nM, Ki=0.99nM) that is shown to act in a reversible and time-dependent manner. It demonstrates selectivity for MPS1 against a panel of 60 kinases, displaying activity against only three kinases, CK2, MELK, and NEK6 (<10uM), but not against other mitotic kinases including PLK1, CDK1, Aurora A, Aurora B, or the SAC kinase BUB1, in an in vitro kinase assay. It promotes massive SAC (spindle assembly checkpoint) override (EC50=65nM) in nocodazole-arrested U20S cells and elicits a reduction in the G1 and G2/M phase of the cell cycle in A2780 ovarian cancer cells, similar to RNAi-mediated MPS1 silencing. In addition, it is shown to inactivate SAC, delocalize kinetochore components, and inhibit the proliferation of select cancer cell lines (IC50 ~1uM), without marked activity among a panel of 127 normal cell lines. Also, it inhibits A2780 tumor xenograft growth in mice (90mg/kg/day, o.s., in vivo) by 53% wit Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| MPTP Hydrochloride (Dopaminergic Neurotoxin, MPTP) | A neurotoxin that is a precusor of MPP+ which is toxic to dopaminergic neurons and causes Parkinsonism. Widely used in research to induce Parkinson's disease models in primates. Group: Biochemicals. Grades: Highly Purified. CAS No. 23007-85-4. Pack Sizes: 10mg. Molecular Formula: C??H??N·HCl. US Biological Life Sciences. | Worldwide |
| MRS 2211 (2-[(2-Chloro-5-nitrophenyl)azo]-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde Sodium Salt, P2Y13 Purinergic Receptor Antagonist, MRS2211, MRS 2211, MRS-2211) | A highly selective and competitive antagonist of P2Y13 purinergic receptor (pIC50 = 5.97). Exhibits about 20-fold greater selectivity over P2Y1 and P2Y12 receptors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MT1-MMP Inhibitor, NSC405020 (3,4-Dichloro-N-(1-methylbutyl)benzamide, 3,4-Dichloro-N-(pentan-2-yl)benzamide) | A cell-permeable pentanylbenzamide compound that acts as an allosteric, reversible, and selective inhibitor of the collgenolytic activity of MT1-MMP. Does not affect the catalytic activity of cellular MT-1-MMP thus allows it to retain its ability to activate MMP-2. Selectively targets the hemopexin (PEX) domain of MT1-MMP, thereby repressing its pro-tumorigenic activity. Its binding to the PEX domain is dependent on Met-328, Arg-330, Asp-376, Met-422, and Ser-470 in the druggable pocket of the enzyme. Shown to block 184B5-MT cell migration on collagen-1 and repress MCF7-b3/MT tumor growth in xenografted mice (0.5mg/kg, intratumoral). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| MTEP Hydrochloride (3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine Hydrochloride) | A non-competitive, potent antagonist highly selective for mGlu5 receptors (IC50 = 5nM). Biologically active admitted orally or systematically. Widely used in assessing the functional roles of mGlu5 receptors in a variety of research areas, such as neuroprotection, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson's disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 1186195-60-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| mTOR Activator, MHY1485 (4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine, Autophagy Inhibitor III) | A cell-permeable triazine derivative that is shown to increase cellular mTOR Ser2448 and downstream substrate 4E-BP Thr37/46 phosphorylation level in rat liver Ac2F cells (1 to 2uM for 1h), affecting culture viability only at much higher concentrations (by 20% after 24h 20uM treatment). MHY1485 induced cellular LC3-II accumulation in Ac2F is reported to be a result of autophagy inhibition due to reduced fusion between autophagosomes and lysosomes. The mechanism of mTOR activation by MHY1485 is currently unknown. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| mTOR Inhibitor XII, Torin2 (9- (6-aminopyridin-3-yl) -1- (3- (trifluoromethyl) phenyl) benzo[h][1, 6]naphthyridin-2 (1H) -one, DNA-PK Inhibitor VII, PI 3-K Inhibitor XIX, PI 4-K Inhibitor) | A Torin1 structural analog that acts as a cell-permeable, potent, ATP-competitive inhibitor against DNA-PK and mTOR (IC50 = 0.5 and 2.81nM, respectively). Comparing to Torin1, Torin2 displays enhanced inhibitory potency against PI 4-Kbeta (IC50 = 18.3nM) and PI 3-K (IC50 =4.68, 5.67, 8.58, 17.5, 24.5, and 28.1nM, respectively, against P110alpha/P85alpha, P110-gamma, hVPS34, P110delta/P85alpha, C2beta, C2alpha, respectively), while being more effective in inhibiting S6K1 Thr389 phosphorylation in MEF cultures (IC50 = 0.25nM vs 2nM, respectively, for Torin2 and Torin1) in vitro and displaying much improved oral bioavailability in mice (Cmax (ng/mL) /T1/2 (h) = 3968/0.72 and 223/0.79, respectively, for Torin2 and Torin1; 10/mg/kg p.o.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O, Primary Target: MTOR. US Biological Life Sciences. | Worldwide |
| mTOR Inhibitor XI, Torin1 (1- (4- (4-propionylpiperazin-1-yl) -3- (trifluoromethyl) phenyl) -9- (quinolin-3-yl) benzo[h][1, 6]naphthyridin-2 (1H) -one, DNA-PK Inhibitor VI, PI 3-K Inhibitor XVIII) | A cell-permeable pyridinonequinoline derivative that acts as a highly potent, ATP-competitive inhibibitor against mTOR and DNA-PK (IC50 = 4.32 and 6.34nM, respectively), while inhibiting PI 3-K only at much higher concentrations (IC50 =171 to 533nM). Effectively inhibits mTORC1-mediated S6K1 phosphorylation in MEF (IC50 = 2nM) in vitro, as well as mTORC2-mediated Akt and mTORC1-dependent S6 phosphorylations in murine lung and liver in vivo (up to 6h post single 20mg/kg i.p. dose). Despite its poor in vivo stability (T1/2 = 4.52h in mice; 10mg/kg i.p.), Torin1 is reported to completely suppress U87MG-derived tumor expansion in mice when administered via daily i.p. at a high dosage of 200mg/kg. Also reported to effectively inhibit cellular mTORC1 functionalities known to be rapamycin-resistant. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Muscimol (GABAA Receptor Agonist, Muscimol) | A constituent and psychoactive ingredient of the mushroom Amanita muscariathat acts as a potent agonist of GABAA receptors (EC50 = 28uM and 33uM in neonatal and adult rats, respectively), with preferential efficacy and selectivity to high-affinity receptor subtypes. Shown to be permeate the blood-brain barrier. Impairs associate and memory functions. Group: Biochemicals. Grades: Highly Purified. CAS No. 2763-96-4. Pack Sizes: 1mg. Molecular Formula: C?H?N?O?. US Biological Life Sciences. | Worldwide |
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