USBiological 4 - Products
Worldwide
Our biochemicals, antibodies, recombinant proteins, cell culture media and molecular biology kits are used in virtually all scientific applications.From affordable research quantities to larger bulk amounts.
| Product | Description | |
|---|---|---|
| Jasmolin II+ Cinerin II + Pyrethrin II (Mixture) | Jasmolin II+ Cinerin II + Pyrethrin II is a by-product from the purification of Pyrethrin 2 (~30%, Technical Grade) (P991240). Pyrethrin is a pesticide most commonly used around homes. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1g, 2.5g. Molecular Formula: C21H28O5; C22H30O5; C22H28O5. US Biological Life Sciences. |  Worldwide |
| JMJD Histone Demethylase Inhibitor III ( (E) -4- (Hydroxy (4- (4- ( (naphthalen-1-ylcarbamoyloxy) methyl) benzylamino) butyl) amino) -4-oxobut-2-enoic Acid) | A substrate (methyl lysine) and cofactor (a-ketoglutarate) mimicking bivalent benzylamino-butylamino-N-hydroxybutenoic acid compound that acts as a selective in vitro inhibitor of Jumonji domain-containing histone demethylases (JHDMs; IC50=4.3, 3.4, 5.9, 10 and 43uM for JMJD2A, JMJD2C, JMJD2E, PHF8 and JMJD3, respectively) over LSD1, asparaginyl and prolyl hydroxylases, and histone deacetylases (IC50=54, 83, 31, 22, 620, 680 and >800uM for PHD1, PHD2, PHD3, FIH, LSD1 and HDACs, respectively). The cellular active JHDM Inhibitor, Methylstat is also available. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| JMJD Histone Demethylase Inhibitor IV, Methylstat ( (E) -Methyl-4- (hydroxy (4- ( (4- ( ( (naphthalen-1-ylcarbamoyl) oxy) methyl) benzyl) amino) butyl) amino) -4-oxobut-2-enoate, Histone Lysine Demethylase Inhibitor VII, Methylstat) | A methyl ester prodrug of in vitro active N-hydroxybutenoic acid compound that is shown to preferentially induce hypermethylation of histone proteins (EC50 for H3K4me3 and H3K9me3=10.3 and 8.6uM in KYSE150 cells, and 6.7 and 6.3uM in MCF7 cells, respectively), and arrests cell growth. Acts as a selective inhibitor of Jumonji domain-containing histone demethylases (JHDMs) over prolyl hydroxylases (PHDs), and prevents myogenesis through inhibition of H3K27 demethylase UTX in C2C12 cells at 2uM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| JNK Inhibitor XVI, JNK-IN-8 ( (E) -3- (4- (dimethylamino) but-2-enamido) -N- (3-methyl-4- ( (4- (pyridin-3-yl) pyrimidin-2-yl) amino) phenyl) benzamide) | A cell-permeable, selective, and irreversible type 2 inhibitor of c-Jun N-terminal kinases (JNK) (IC50=4.67nM, 18.7nM, 980pM for JNK1, JNK2, and JNK3, respectively). Forms a covalent adduct with the conserved cysteine residue (Cys116 in JNK1) and binds to JNK in an extended type 2 conformation. Blocks the phosphorylation of c-Jun in cells (EC50=486nM in HeLa cells; 338nM in A375 cells). Exhibits greater cellular specificity for JNK when compared to 40 other kinases screened using a cell-based assay. Shows weaker binding to KIT mutants (IC50=92nM for V559D and 56nM for T670I) and RIOK2 (120nM). Does not show any significant inhibitory activity against various other kinases, including ERK, p38, Akt, MSK, and RSK. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| JNK Inhibitor XV, IQ-1S (11H-Indeno[1,2-b]quinoxalin-11-one oxime, sodium salt) | A cell-permeable indenoquinoxalinone-oxime (IQ) compound that acts as a potent, non-toxic, reversible, ATP-competitive, high-affinity inhibitor of JNK (=390, 360 and 87nM for JNK1, JNK2 and JNK3, respectively) with moderate selectivity over CK1d, PI 3-Ky, and MKNK2 (IC50=1.4, 1.2, and 1.8uM, respectively). Shown to reduce c-Jun-Ser63 phosphorylation, and block the production of LPS-induced TNF-a (IC50 = 250nM) and IL-6 (IC50=610nM) in MonoMac-6 monocytic cells and in human hPBMCs, respectively. Also shown to inhibit NF-kB/AP-1 reporter activity (IC50=1.8uM) in human THP1-Blue monocytic cells and diminish nitric oxide production in murine J774-A.1 macrophages (IC50=12.5uM). Exhibits favorable pharmacokinetics properties and efficiently reduces ovalbumin-induced CD+ T-cell immune inflammation in a murine delayed-type hypersensitivity model (12.5mg/kg, two per day dosage, i.p.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H?N?Ona, Primary Target: JNK1,2,3. US Biological Life Sciences. | Worldwide |
| JQ1 Enantiomers Set ((S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate, SGCBD01, BRD2 Inhibitor III, BRD3 Inhibitor II, BRD4 Inhibitor III, BRD6 Inhibitor I, BRDT Inhibitor I) | A cell-permeable I-BET class of thienodiazepine derivative whose (S)-(+), but not (R)-(-), enantiomer is shown to target both bromodomains (BD1 & BD2) of BET family members BRD2, BRD3, BRD4, and BRD6/BRDT in a Kac- (epsilon-N-acetylated lysine) competitive manner, exhibiting little affinity toward 23 other BD-containing proteins, BRD1 and BRD9, and little or no activity against a panel of more than 50 receptors, ion channels, and transporters. Effectively inhibits the oncogenic BRD4-NUT fusion-dependent NUT midline carcinoma and c-Myc oncoprotein-dependent multiple myeloma proliferation both in cultures (IC50 <1uM) in vitro and in mice (50mg/kg/day i.p.) in vivo. Also reported to cross the blood-testis boundary in male mice and effectively block BRDT-mediated spermatogenesis without affecting hormone levels. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1set. US Biological Life Sciences. | Worldwide |
| Kartogenin, CBF-beta Activator (2-(Biphenyl-4-ylcarbamoyl)benzoic Acid) | A cell-permeable biphenyl carbamoyl benzoate compound that potently induces the differentiation of human mesenchymal stem cells (hMSCs) into chondrocytes (EC500nM). Reversibly binds to the FC-1 fragment of filamin A and disrupts its association with CBFB leading to nuclear localization of CBFB and binding to runt-related transcription factor (RUNX) to regulate chondrogenesis. Also reported to inhibit cytokine-induced release of nitric oxide (NO) and glycosaminoglycan (GAG). Exhibits chondroprotective properties and promotes cartilage repair in murine osteoarthritis models. Shown to up-regulate the levels of TIMP1, collagen, and aggrecan thereby blocking further matrix breaown without affecting the activities of MMP-3, MMP-13, and aggrecanase in primary chondrocytes or hMSCs. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??NO?, Molecular Weight: 317.3. US Biological Life Sciences. | Worldwide |
| Kendomycin ((-)-TAN 2162) | Antibiotic. Potent endothelin receptor antagonist. Anti-osteoporotic. Antibacterial. Cytotoxic. Mediates its cytotoxic effects, at least in part, through proteasome inhibition. Group: Biochemicals. Grades: Highly Purified. CAS No. 183202-73-5. Pack Sizes: 100ug, 500ug. US Biological Life Sciences. | Worldwide |
| Ketamine-d6 Hydrochloride. Replaces K165302. | Ketamine-d6 is labelled Ketamine (K165300, HCl salt). It is an anesthetic (intravenous). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 5mg. Molecular Formula: C13H11D6Cl2NO, Molecular Weight: 280.22. US Biological Life Sciences. | Worldwide |
| Ketanserin Tartrate (5-HT2A Serotonin Receptor Antagonist, Ketanserin, R 41 468) | A selective 5-HT2A serotonin receptor antagonist with weak adrenergic receptor blocking properties. Strong affinity for 5-HT2AR (Ki = 1.49nM) relative to other family members like 5-HT2BR (Ki = 740nM) and 5-HT2CR (Ki = 59nM). Often used in conjunction with SB 206553 to distinguish 5-HT2AR and 5-HT2CR activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 83846-83-7. Pack Sizes: 50mg. Molecular Formula: C??H??FN?O?·C?H?O?. US Biological Life Sciences. | Worldwide |
| Ketohexokinase Inhibitor (N8-(Cyclopropylmethyl)-N4-(2-(methylthio)phenyl)-2-(1-piperazinyl)-pyrimido[5,4-d]pyrimidine-4,8-diamine, KHK Inhibitor) | An orally bioavailable pyrimidinopyrimidine compound that acts as a potent, reversible and ATP-competitive inhibitor of human hepatic KHK activity (KHK-C isoform; IC50=12nM in a transcreener ADP assay) and efficiently blocks fructose-1-phosphate secretion (IC50 ≤ 400nM in HepG2 cells). Displays ~50-fold lower potency towards metabolic kinases, namely, ribokinase, hexokinase and adenosine kinase, and minimal binding affinities to diverse receptors and ion-channels, and excellent selectivity among a panel of 31-kinases including Akt1, AMPK, CaMKI/II, InsR, IRAK4, PKA and PKCtheta (IC50 >> 10uM). Shown to minimally affect the activities of human cytochrome p450 isozymes (1A2, 2C19, 2D6, 2C9 and 3A4), and exhibit high volume of distribution and high rate of clearance in rats. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?S 2HCl. US Biological Life Sciences. | Worldwide |
| Kir1.1 Inhibitor, VU591 (Inward Rectifier Potassium Channel Kir1.1 Blocker, VU591) | A cell-permeable, benzoimidazole, renal outer medullary potassium channel (ROMK) blocker that selectively inhibits inward rectifier potassium channel, Kir1K.1 (IC50=240nM), in HEK-293 cells. At 10uM, it displays no effect on Kir2.1, Kir2.3, Kir4.1, and Kir7.1, with 150-fold selectivity over Kir6.2. In addition, it exhibits a modest off-target effect on the GABAA receptor (IC50=6.2uM) among a panel of cardiac and central nervous system ion channels and receptors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Kir2.1 Inhibitor, ML133 (Inward Rectifier Potassium Channel Blocker, ML133) | A cell-permeable, renal outer medullary potassium (ROMK) blocker that is shown to inhibit inward rectifier potassium channel, Kir2.1 (IC50=1.8uM and 290nM, at pH 7.4 and pH 8.5, respectively). It exhibits little selectivity against other members of the Kir2.x family, but has no effect on Kir1.1 (IC50 >300uM) and displays weak activity for Kir4.1 and Kir7.1 (IC50=76uM and 33uM, respectively). It is reported to be assayed in 218 MLPCN HTS campaigns, demonstrating activity in only two assays that are not based on Kir2.1. Furthermore, it displays a relatively clean profile in a radioligand binding panel of 68 GPCRs, ion channels and transporters. Group: Biochemicals. Grades: Highly Purified. CAS No. 185669-79-8. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Kirromycin (Mocimycin, Delvomycin, MYC 8003, NSC 316094) | Antibiotic. Member of the elfermycin group. Antibacterial. Protein biosynthesis inhibitor. Specifically interacts with the bacterial elongation factor EF-Tu and prevents the release of EF-Tu from the bacterial ribosome after GTP hydrolysis. In the absence of ribosomes it induces EF-Tu-dependent hydrolysis of GTP. Animal growth promoter used in poultry breeding. Group: Biochemicals. Grades: Highly Purified. CAS No. 50935-71-2. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| KLF5 Inhibitor, CID 5951923 (2- ( (1, 1-Dioxidotetra hydrothiophen-3-yl, methyl)amino)-2-oxoethyl-(2E)-3-(3-nitrophenyl)prop-2-enoate) | A cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC50=1.6uM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr1068 and ERK1/2-Thr202/Tyr204. Also, up-regulates the phosphorylation of p38 MAPK-Thr180/Tyr182. Group: Biochemicals. Grades: Highly Purified. CAS No. 749872-43-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| KMO Inhibitor I, Ro 61-8048 (Kynurenine-3-Monooxygenase Inhibitor I, Ro 61-8048 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide Dimethoxy-nitrophenyl-thiazolyl-benzenesulfonamide, Kynurenine-3-Hydroxylase Inhibitor I, Ro 61-8048) | A cell-permeable thiazolyl Benzene sulfonamide compound that acts as a potent, competitive and reversible inhibitor of kynurenine-3-monooxygenase activity (Ki=4.8nM; IC50=37nM). Reported to increase the circulating levels of kynurenic acid (KYNA), an excitatory amino acid receptors antagonist, lower reactive oxygen species [ROS], reduce neuronal loss and enhance the survival rate in several neuronal disease models. An orally bioavilable KMO Inhibitor II, JM6, a prodrug of Ro 61-8048 is also available. Group: Biochemicals. Grades: Highly Purified. CAS No. 199666-03-0. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S?, Molecular Weight: 421.5. US Biological Life Sciences. | Worldwide |
| KPT 330 Hydrochloride | KPT 330 Hydrochloride, is a chromosome maintenance protein 1 (CRM1) inhibitor. KPT 330 suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C17H11F6N7O; HCl, Molecular Weight: 443.313646. US Biological Life Sciences. | Worldwide |
| KT5823 (2, 3, 9, 10, 11, 12- hexahydro- 10R- methoxy- 2, 9- dimethyl- 1- oxo- 9S, 12R- epoxy- 1H- diindolo[1, 2, 3- fg:3, 2, 1- kl]pyrrolo[3, 4- i][1, ]benzodiazocine- 10- carboxylic acid, methyl ester) | Cell-permeable. KT5823 is a derivative of K-252a that acts as a selective inhibitor of Protein kinase G (PKG) (Ki = 0.234um). Inhibits other kinases at much higher concentrations (Kis for PKA=4um and for MLCK=>10um). Group: Biochemicals. Grades: Highly Purified. CAS No. 126643-37-6. Pack Sizes: 50ug. US Biological Life Sciences. | Worldwide |
| L-2',6'-Dimethyltyrosine | L-2',6'-Dimethyltyrosine (Dmt) enhances receptor affinity, functional bioactivity and in vivo analgesia of opioid peptides. Group: Biochemicals. Grades: Highly Purified. CAS No. 123715-02-6. Pack Sizes: 100mg, 500mg. Molecular Formula: C11H15NO3, Molecular Weight: 209.24. US Biological Life Sciences. | Worldwide |
| L-(+)-2-Amino-4-phosphonobutyric Acid (L-AP4) | Phosphonic acid analog of L-glutamic acid. A selective group III metabotropic glutamate receptor agonist. Also a potent, pathway-specific synaptic depressant. Group: Biochemicals. Grades: Highly Purified. CAS No. 23052-81-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| L3MBTL3 MBT Domain Blocker, UNC1215 (Lethal(3)malignant Brain Tumor-like Protein 3 MBT Domain Blocker, 2-Phenylamino-1, 4-bis (4- (pyrrolidinyl) piperidinyl) benzamide, TFA, 2-(Phenylamino)-1,4-phenylene-bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone, TFA) | A cell-permeable pyrrolidinyl-piperidinyl-benzamide that effectively competes against H4K20Me2 peptide for L3MBTL3 binding by targeting the first two L3MBTL3 MBT domains (Kd = 120nM in binding studies using recombinant 3MBT fragment), while exhibiting much reduced potency against L3MBTL1-H4K20Me1, 53BP1-H4K20Me2, MBTD1-H4K20Me1, or L3MBTL4-H2AK36Me1 interaction (IC50 ≥2uM; [peptide] = 150nM). Shown to increase GFP-L3MBTL fusion nucleus mobility (10nM to 1uM) in HEK293 transfectants. X-ray structural analysis reveals two 3MBT are bridged together by two UNC1215 molecules in a reciprocal fashion. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| L-701,324 (7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone) | A highly potent and selective antagonist for thenMDA receptor glycine site (IC50 = 2.0nM; Kd = 28nM; ED50 = 0.9nM either intraperitoneal (ip) or oral (po) adminited). The first such compounds with significant activity in the central nervous system following oral dosing and a potent, active anticonvulsant with a reduced propensity to activate mesolimbic dopaminergic systems in rodents. Group: Biochemicals. Grades: Highly Purified. CAS No. 142326-59-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| L-741,626 (Dopamine D2 Receptor Antagonist, L-741,626, L-741626, L741626) | Selective dopamine D2 receptor antagonist that is shown to reversibly block agonist-induced activation of GIRK currents. Reported to have a 15-fold selectivity for D2R over D3R in vitro. Inhibition of 3H-spirperone binding to cloned rat Dopamine receptors show the following Ki values: D2R (7.1nM), D3R (155nM), D4R (596nM). Commonly used D2 inhibitor in addiction research. Group: Biochemicals. Grades: Highly Purified. CAS No. 81226-60-0. Pack Sizes: 10mg. Molecular Formula: C??H??ClN?O. US Biological Life Sciences. | Worldwide |
| L-745,870 Trihydrochloride (Dopamine D4 Receptor Antagonist, L-745,870 Trihydrochloride, L-745870, L745870) | Selective D4 receptor antagonist with excellent brain penetration. Displays an affinity (Ki) of 0.4nM for human D4 receptors with >1000-fold binding selectivity over D2 and D3 receptors. Does not block agonist-induced activation of GIRK currents. It is used frequently in retinal and CNS studies of D4 modulation. Group: Biochemicals. Grades: Highly Purified. CAS No. 158985-00-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Lactate Dehydrogenase A Inhibitor, FX11 (LDHA Inhibitor I, LDH-A Inhibitor I, LDH-M Inhibitor I, LDHM Inhibitor I) | A cell permeable, gossypol analog that acts as a selective, reversible, and NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8uM for human liver LDHA). Does not affect the activities of LDHB and glyceraldehyde-3-phosphate dehydrogenase even at higher concentrations. Shown to increase oxygen consumption, reactive oxygen species production, and cell death in P493 human lymphoma B cells. Also shown to reduce mitochondrial transmembrane potential and ATP levels and increase AMP kinase activity. Exhibits synergistic toxicity in P493 cells when combined with FK866. Blocks the progression of human lymphoma and pancreatic cancer xenografts and when used in combination with FK866 it induces lymphoma regression. Group: Biochemicals. Grades: Highly Purified. CAS No. 213971-34-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Lactosamine | Lactosamine forms the backbone of several cell surface glycans such as sialylated glycans or keratin sulfates. Also, it is a basic structural element of Lewis type, and human milk oligosaccharides. Group: Biochemicals. Grades: Highly Purified. CAS No. 13000-25-4. Pack Sizes: 5mg, 10mg. Molecular Formula: C12H23NO10, Molecular Weight: 341.31. US Biological Life Sciences. | Worldwide |
| L-Alanyl-L-Glutamine, Liquid (Glutamax) | Cell Culture substitute for Glutamine, offering greater thermal stability with lowered ammonia build-up. L-Alanyl-L-glutamine is a stable synthetic glutamine dipeptide. This dipeptide is used as an alternative source of amino acids in cell culture medium. Group: Biochemicals. Alternative Names: N2-L-Alanyl-glutamine; N2-L-Alanyl-L-glutamine; 72: PN: US20070066537 PAGE: 17 claimed protein; 96: PN: WO2011146121 PAGE: 115 claimed sequence; Alanyl-glutamine; Dipeptamin; Dipeptiven; GlutaMAX; Glutamax I; L-Ala-L-Gln; Sustamine. Grades: Cell Culture Grade. CAS No. 39537-23-0. Pack Sizes: 100ml, 250ml, 500ml. Molecular Formula: C8H15N3O4, Molecular Weight: 217.22. US Biological Life Sciences. | Worldwide |
| L-a-lysophosphatidyl inositol Sodium Salt, Soy (L-a-lysophosphatidyl inositol LPI, Lyso PI, Soy Lyso PI) | A potent agonist and assumed endogenous ligand of GPR55, shown to induce rapid phosphorylation of p38 mitogen-activated protein kinase (MAPK) and its downstream activating transcription factor 2 (ATF2) in both GPR55-transfected HEK293 cells, and in IM-9 lymphoblastoid cells naturally expressing GPR55 at 1uM, while having no effect on vector-transfected cells. In addition, shown to enhance serum induced cell migration in MCF-7 cells over expressing GPR55. Group: Biochemicals. Grades: Highly Purified. CAS No. 796963-91-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| lambda-Carrageenan(Low-viscosity) | lambda-Carrageenan(Low-viscosity). Group: Molecular Biology. CAS No. 9064-57-7. Pack Sizes: 1g, 5g. US Biological Life Sciences. | Worldwide |
| Laquinimod | A potent immunomodulator. Also displays anti-inflammatory properties. Group: Biochemicals. Alternative Names: 5-chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide. Grades: Highly Purified. CAS No. 248282-07-7. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| L-Ascorbic Acid, 2-Phosphate Magnesium Salt | L-Ascorbic acid is essential for the synthesis of collagen, with deficiency resulting in scurvy.1 Notably, humans and other primates, guinea pigs, and certain other animals lack an enzyme necessary for vitamin C synthesis.1 L-Ascorbic acid 2-phosphate (AA2P) is a long-acting ascorbic acid derivative that stimulates collagen expression and formation and is used in human cell culture.2,3 It may be included in media to enhance the survival of human embryonic stem cells or increase the growth and replicative lifespan of human corneal endothelial cells.4,5 AA2P is also used to drive osteogenic differentiation in human adipose stem cells and in human mesenchymal stromal/stem cells.6,7,8. Group: Biochemicals. Alternative Names: Ascorbic acid phosphate dimagnesium salt; Ascorbyl PM; Magnesium ascorbyl phosphate; Phospitan C. Grades: Cell Culture Grade. CAS No. 113170-55-1. Pack Sizes: 5g, 10g. Molecular Formula: C?H?O?P 1.5Mg, Molecular Weight: 289.5. US Biological Life Sciences. | Worldwide |
| Lauric Acid-d3 | Lauric Acid-d3, is the labeled analogue of Lauric Acid (L178550), a common saturated fatty acid found in nutmeg, palm kernel oil, coconut oil and butter fat. Group: Biochemicals. Grades: Highly Purified. CAS No. 79050-22-9. Pack Sizes: 10mg, 50mg. Molecular Formula: C12H21D3O2, Molecular Weight: 203.34. US Biological Life Sciences. | Worldwide |
| L- Buthionine Sulfoximine | A cell-permeable, sulfoximine based compound that acts a potent, fast acting, irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. Closely resembles the structure of g-glutamylphosphate cysteine adduct. The inhibition follows the first order kinetics with t1/2 = ~11 sec at saturating inhibitor concentration. Does not affect the activity of glutamine synthetase. Shown to improve the outcome of chemotherapy by lowering the levels of glutathione in cancer cells (IC50 = 1.9, 8.6, and 29uM in melanoma, breast, and ovarian tumor cells, respectively). Group: Biochemicals. Grades: Highly Purified. CAS No. 83730-53-4. Pack Sizes: 100mg. Molecular Formula: C?H??N?O?S. US Biological Life Sciences. | Worldwide |
| L-CCG-I | A potent agonist for group II metabotropic glutamate receptors (EC50 = 0.49uM and 0.44uM for mGlu2 and mGlu3, respectively). Higher level of activity than glutamate or (±)-trans-ACPD. Widely used in studies related to neurotransmissions mediated via group II mGlu receptors. Group: Biochemicals. Grades: Highly Purified. CAS No. 117857-93-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| L-Dierucoyl Lecithin | L-Dierucoyl Lecithin is a phospholipid that is used in the formation of netural lipid bilayer membranes for the purposes of research and experimentation in the fields of biology and biochemistry. L-Dierucoyl Lecithin is a derivative of Lecithin, a phospholipid that is an important component of naturally occurring, biological membranes. Group: Biochemicals. Grades: Highly Purified. CAS No. 51779-95-4. Pack Sizes: 250mg, 2.5g. Molecular Formula: C52H100NO8P, Molecular Weight: 898.33. US Biological Life Sciences. | Worldwide |
| LDN-211904 (N-(2-chlorophenyl)-6-(piperidin-4-yl)imidazo[1,2-a]pyridine-3-carboxamide Ooxalate, EphB3 Inhibitor) | A pyrazolo[1,5-a]pyridine derivative that acts as an potent and reversible EphB3 receptor tyrosine kinase inhibitor with an IC50 of 79nM with good mouse liver microsomal stability and aqueous solubility. Shown to suppress EphB3-induced autophosphorylation of EphB3 receptor at 10uM in cells. When profiled against a panel of 288 kinases at 5uM, found to also inhibit most of the Eph (Erythropoietin-producing hepatocellular carcinoma) receptor kinases including EphA1, EphA2, EphA3, EphA4, EphA5, EphA8, EphB1, EphB2, EphB3, EphB4 and other tyrosine kinases, but not EphA6 and EphA7, and is non-inhibitory towards non-RTK kinases screened except for p38α, p38b, and Qik. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??ClN?O?, Molecular Weight: 444.9. US Biological Life Sciences. | Worldwide |
| Lead(II) Oxide | Lead(II) Oxide is used as the starting material in the synthesis of Dibasic Lead Phthalate Hydrate (D417070); a compound that is used in vinyl wire insulation as a flame retardant. Group: Biochemicals. Grades: Highly Purified. CAS No. 1317-36-8. Pack Sizes: 1g, 5g. Molecular Formula: OPb, Molecular Weight: 223.2. US Biological Life Sciences. | Worldwide |
| L-(-)-Epinephrine-(+)-bitartrate (1-(3,4-Dihydroxyphenyl)-2-(methylamino)ethanol) | a,b-Adrenergic receptor agonist. Has positive chronotropic and inotropic effects on heart muscle. Activates adenylate cyclase to generate cAMP from ATP. Group: Biochemicals. Grades: Highly Purified. CAS No. 51-42-3. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Leucettine L41 ((5Z)-5-(1,3-Benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4one) | Potent inhibitor of DYRKs and CLKs. Interacts also with GSK-3alpha/beta, CK2 and PIM1. Interacts with the complex PIKfyve/Vac14/Fig4. Modulates alternative splicing of pre-mRNA in various cellular systems. Neuroprotective against APP-induced cell death. Tools to study and modulate pre-RNA splicing. Potential compound for Alzheimer's disease and diseases involving abnormal pre-mRNA splicing. Potential compound to study Down syndrome (inhibition of DYRK1A). Neuroprotective against glutamate-induced cell death. Group: Biochemicals. Grades: Highly Purified. CAS No. 1112978-84-3. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Leukadherin-1 (aMb2 Agonist II, CD11b Agonist II, LA1, Mac-1 Agonist II, CR3 Agonist II, CD11b/CD18 Agonist, 4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic Acid) | A furanyl thiazolidinone compound that binds CD11b aA/aI domain in a reversible manner and stabilizes aA in a high-affinity binding conformation toward known CD11b/CD18 (aMB2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B. Reported to be superior to IMB-10 in enhancing Mac-1-mediated cell adhesion (EC50=4 vs. >50uM on fibrinogen surface). Effectively suppresses leukocyte recruitment in various inflammatory disease models involving mice, rats, and zebrafish embryos in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Levomethorphan Hydrobromide | Levomethorphan Hydrobromide is an enantiomer of Dextromethorphan; an antitussive medicine and narcotic. Group: Biochemicals. Grades: Highly Purified. CAS No. 125-68-8. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C18H26BrNO. US Biological Life Sciences. | Worldwide |
| LIM Kinase Inhibitor I, LIMKi 3 (N-(5-(1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyramide) | A cell-permeable pyrazolylthiazolo-isobutyramide compound that acts as a potent LIM kinase inhibitor (IC50 = 7 and 8nM against LIMK1 and LIMK2, respectively) and effectively suppresses cellular cofilin phosphorylation (IC50 ~1uM in A549 and MDA-MB-231 cultures) without affecting tubulin polymerization or inducing cytotoxicity (EC50 >10uM in A549 proliferation & colony formation assays). Shown to effectively destabilize F-actin structure in MDA-MB-231 breast cancer cells (3 to 10uM) with concomitant blockage of invasion (by 93% at 10uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 1338247-35-0. Pack Sizes: 10mg. Molecular Formula: C??H??Cl?F?N?OS. US Biological Life Sciences. | Worldwide |
| Linolenic Acid | Linolenic Acid. Group: Molecular Biology. Grades: Purified. CAS No. 463-40-1. Pack Sizes: 25ml. Molecular Formula: C18H30O2. US Biological Life Sciences. | Worldwide |
| Lithium (3-fluoro-6-methylpyridin-2-yl)trihydroxyborate | Lithium (3-fluoro-6-methylpyridin-2-yl)trihydroxyborate. Group: Biochemicals. Grades: Highly Purified. CAS No. 1393822-97-3. Pack Sizes: 25mg, 50mg. Molecular Formula: C6H8BFLiNO3, Molecular Weight: 178.88. US Biological Life Sciences. | Worldwide |
| Lithocholic acid (3alpha-Hydroxy-5beta-cholan-24-oic acid, 3alpha-Hydroxy-5beta-cholanic acid, 5beta-Cholan-24-oic acid-3alpha-ol, LCA) | Lithocholic acid (LCA) is a hydrophobic secondary bile acid that acts as a detergent to solubilize fats for absorption. Known to display both carcinogenic and apoptotic activities. Also binds to the p53 binding sites of both MDM2 and MDM4 with a five-fold preference for MDM4. Group: Biochemicals. Grades: Highly Purified. CAS No. 434-13-9. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| L+Lactic Acid, Calcium Salt, Pentahydrate | Lactic acid (2-hydroxypropanoic acid), also known as milk acid, is a chemical compound that plays a role in several biochemical processes. It was first isolated in 1780 by a Swedish chemist, Carl Wilhelm Scheele, and is a carboxylic acid with a chemical formula of C3H6O3. It has a hydroxyl group adjacent to the carboxyl group, making it an alpha hydroxy acid (AHA). In solution, it can lose a proton from the acidic group, producing the lactate ion CH3CH(OH)COO?. It is miscible with water or ethanol, and is hygroscopic. Lactic acid is chiral and has two optical isomers. One is known as L-(+)-lactic acid or (S)-lactic acid and the other, its mirror image, is D-(-)-lactic ac...or Hartmann's Solution in the UK). This intravenous fluid consists of sodium and potassium cations, with lactate and chloride anions, in solution with distilled water in concentration so as to be isotonic compared to human blood. It is most commonly used for fluid resuscitation after blood loss due to trauma, surgery, or a burn injury. Group: Biochemicals. Alternative Names: Lactic Acid Calcium Salt (2:1) Pentahydrate; Propanoic Acid 2-Hydroxycalcium Salt Pentahydrate; Calcium Lactate Pentahydrate; Puracal DC. Grades: USP. CAS No. 5743-47-5. Pack Sizes: 100g, 250g, 500g, 1Kg, 2.5Kg. Molecular Formula: C6H10O6 Ca 5H2O, Molecular Weight: 308.29. US Biological Life Sciences. | Worldwide |
| L-Lysine-L-Amphetamine Dihydrochloride | L-Lysine-L-Amphetamine Dihydrochloride is an analogue of Lisdexamphetamine Dihydrochloride (L468880), a new, novel amphetamine product, has been shown to provide efficacy upwards of 12 h in children and adults with a side effect profile similar to those of other longer-acting amphetamine products. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg, 1g. Molecular Formula: C15H27Cl2N3O, Molecular Weight: 336.3. US Biological Life Sciences. | Worldwide |
| Longdaysin (Casein Kinase I Inhibitor VII, 9-Isopropyl-N- (3- (trifluoromethyl) benzyl) -9H-purin-6-amine) | A cell-permeable purine compound that acts as a reversible and ATP-competitive dual inhibitor of CKIa and CKId activities (IC50 = 5.6 and 8.8uM) with moderate selectivity over Cdk7 and Erk2 (IC50 = 29 and 52uM). Shown to block CKIa/d-mediated phosphorylation of PER1, a clock protein, (IC50 ~9uM) and repress PER1 proteasomal degradation, and lengthen the circadian period in U2OS cells (by ~13hrs at 10uM) much more effectively than Casein Kinase I Inhibitor, D4476 and IC261 and in larval zebra fish. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Loperamide Hydrochloride (mu-Opioid Receptor Agonist, Loperamide Hydrochloride, Imodium) | A very potent and highly selective peripheral resctricted u-opioid receptor agonist (Ki = 2nM). Often used as an antidiarrheal, antipruritic, and antihyperalgesic agent. In addition, shown to improve defective post-receptor insulin signaling in skeletal muscle cells and enhance insulin sensitivity in rats. Group: Biochemicals. Grades: Highly Purified. CAS No. 34552-83-5. Pack Sizes: 1g. Molecular Formula: C??H??ClN?O?·HCl. US Biological Life Sciences. | Worldwide |
| Lorazepam Acetate | Lorazepam Acetate has been commonly used in the study of its stereoselective binding to human serum albumin (HSA). Group: Biochemicals. Grades: Highly Purified. CAS No. 2848-96-6. Pack Sizes: 10mg, 100mg. Molecular Formula: C17H12Cl2N2O3, Molecular Weight: 363.19. US Biological Life Sciences. | Worldwide |
| Loxoribine | Guanosine analog derivatized at position N7 and C8. Very potent immunostimulatory compound that increases cytokine production. Antitumor and antiviral activity compound. Potent and selective synthetic ligand for Toll-like receptor 7 (TLR7). Co-incubation with thymidine homopolymer oligodeoxynucleotides (ODN) redirected the stimulatory effect of loxoribine away from TLR7 toward TLR8. Induces autophagy and autophagy-induced cell death in Caco-2 cells. Shows adjuvant activity to increase the effectiveness of vaccines. Group: Biochemicals. Alternative Names: 7-Allyl-8-oxoguanosine; RWJ 21757, 7-Allyl-2-amino-9-(3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-7,9-dihydro-1H-purine-6,8-dione. Grades: Highly Purified. CAS No. 121288-39-9. Pack Sizes: 5mg, 25mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| LP-44 Hydrochloride | A potent agonist of the 5-HT7 serotonin receptor (Ki= 0.22nM) with good selectivity against other 5-HT receptors (5-HT1A Ki = 52.7nM, 5-HT1B Ki = 60nM). Often used in conjuction with the selective 5-HT7 receptor antagonist, SB-269970. Group: Biochemicals. Grades: Highly Purified. CAS No. 824958-12-5. Pack Sizes: 10mg. Molecular Formula: C??H??ClN?OS. US Biological Life Sciences. | Worldwide |
| LRRK2 Inhibitor II, CZC-25146 (N- (2- (5-Fluoro-2- (2-methoxy-4-morpholinophenylamino) pyrimidin-4-ylamino) phenyl) methanesulfonamide, HCl, N- (2- (2- (2-Methoxy-4-morpholinophenylamino) -5-fluoropyrimidin-4-ylamino) phenyl) methanesulfonamide, HCl) | An orally bioavailable fluoro-diaminopyrimidine compound that acts as a potent, reversible and ATP-competitive inhibitor of LRRK2 activity (IC50=4.76 and 6.87nM for hr-wt-LRRK2 and G2019S-LRRK2 mutant, respectively) with selectivity over PLK4, GAK, TNK1, CAMKK2, and PIP4K2C (IC50 <300nM) in a 185-kinase panel. Does neither exert cytotoxicity nor block neuronal development of human or rat cortical neurons at 1uM. Shown to prevent GS-LRRK2-induced neuronal injury (EC50 ~4nM) and G2019S- or R1441C-LRRK2-mediated neuronal death in both rat and human cortical neurons (EC50 ~100nM). Even though exhibits favorable pharmacokinetic profile and metabolic stability, and yet suffers from limited blood brain barrier penetration (~4%). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| LRRK2 Inhibitor III, HG-10-102-01 (Leucine-Rich Repeat Kinase 2 Inhibitor III, Mixed-Lineage Kinase 1 Inhibitor I, MLK1 Inhibitor I, MNK Inhibitor III, (4- (5-Chloro-4- (methylamino)pyrimidin-2-ylamino)-3-methoxyphenyl) (morpholino)methanone) | A cell-permeable 2,4-diaminopyrimidinyl compound that acts as a potent, ATP-competitive LRRK2-selective inhibitor (IC5050 = 20.3, 3.2, 153.7 and 95.9nM, respectively,against human wt LRRK2 and G2019S, A2016T, G2019S/A2016T LRRK2 mutant; [ATP] = 100uM), displaying much reduced potency against MNK2 and MLK1 (IC50 = 0.6 and 2.1uM, respectively; [ATP] = 100uM) and little activity toward a panel of 136 other kinases. Although both HG-10-102-01 and LRRK2-In-1 inhibit cellular wt and G20195 LRRK2 phosphorylation (Optimal conc. 1 to 3uM), only HG-10-102-01 is effective against cellular A2016T and G2019S/A2016T LRRK2 phosphorylations (IC50 <3uM). And only HG-10-102-01, but not LRRK2-In-1 or CZC-25146, can cross blood-brain-barrier for LRRK2 phosphorylation inhibition in mice (30mg/kg to 50mg/kg i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??ClN?O?. US Biological Life Sciences. | Worldwide |
| LSD1 Inhibitor IV, RN-1,HCl (2- (1R, 2S) -2- (4- (Benzyloxy) phenyl) cyclopropylamino) -1- (4-methylpiperazin-1-yl) ethanone, HCl, Lysine (K)-Specific Demethylase Inhibitor IV,RN-1,HCl, BHC110 Inhibitor IV, KDM1 Inhibitor IV, MOA Inhibitor III) | A cell-permeable tranylcypromine (parnate) analog that acts as a potent, irreversible inhibitor of lysine specific demethylase 1 (LSD1; IC50=70nM in a HRP-coupled assay using H3K4Me2 peptide substrate). Forms a covalent adduct with flavin adenine dinucleotide (FAD). Shown to cross the blood brain barrier. Exhibits moderate selectivity over amine oxidases MAO-A and MAO-B (IC50=0.51 and 2.785uM, respectively). Displays desirable pharmacokinetic properties (brain/plasma exposure ratio of 88.9), and impairs long-term memory without affecting short-term memory in mice (10mg/kg, i.p.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| LSF Inhibitor, FQI1 ((±, 8-(2-Ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6(5H)-one Factor Quinolinone Inhibitor 1, Racemic) | A cell-permeable dihydroquinolinone compound that acts as a potent, specific, and reversible inhibitor of DNA-binding activity of Late SV40 Factor (LSF) and blocks LSF transactivation (IC50=2.1uM in NIH 3T3 cells). Exhibits anti-proliferative activity and growth arrest in multiple cell lines (GI50=3.8, 0.79, and 6.3uM in NIH 3T3, HeLa S3 and A549 cells, respectively). Shown to induce apoptotic cell death in liver cancer cell lines over-expressing LSF without affecting primary or immortalized hepatocytes. Also shown to inhibit hepatocellular carcinoma s.c. growth in mouse xenograft model without any toxic effects (1mg/kg, i.p., once every 3 days). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Luisol A | Shows weak cytotoxic activity against different tumor cell lines, also has antiparasitic activity. Group: Biochemicals. Alternative Names: (4R, 6S, 6aR, 7S, 12R, 12aS)-6a, 7, 8, 12-Tetrahydroxy-6-methyl-3, 4, 6, 6a, 7, 12-hexahydro-2H-4, 12a-methano-naphtho[2, 3-b][1, 5]dioxocin-2-one. Grades: Highly Purified. CAS No. 225110-59-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Luteolin (3',4',5,7-Tetrahydroxyflavone, Luteolol, BRN 0292084, C.I. Natural Yellow 2, Digitoflavone, Flacitran, Flavopurpol, Daphneflavonol, Argemexitin) | Anticancer and antimetastatic. alpha-Glucosidase inhibitor. Topoisomerase I Inhibitor. Apoptosis inducer. Anti-inflammatory. 15-Lipoxygenase (15-LOX) inhibitor. IL-6 production inhibitor. Fatty acid synthase (FAS) inhibitor. Antioxidant. Free radical scavenger. Antiadipogenic. PPAR-y. inhibitor. Neuroprotective. Monoamine transporter activator. Inhibitor of phosphodiesterases 1-5 (PDE1-5). PKC(e) and Src kinase inhibitor. HDAC inhibitor. Autophagy modulator. Phosphatidylinositol 3-kinase (PI3K) / Akt signaling inhibitor. p90 ribosomal S6 kinase (RSK1/RSK2) kinase activity inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 491-70-3. Pack Sizes: 5mg, 25mg. Molecular Formula: C15H10O6. US Biological Life Sciences. | Worldwide |
| LY-333,531 hydrochloride (Ruboxistaurin) | An isozyme-selective inhibitor of protein kinase Cb (PKCb). Inhibits both the PKCbI (IC??=4.7 nM) and PKCbII (IC??=5.9nm) isozymes. LY-333,531 is 76- and 61-fold more selective for inhibition of PKCbI and PKCbII over PKCa. Group: Biochemicals. Grades: Highly Purified. CAS No. 169939-93-9. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| LY 344864 Hydrochloride (5-HT1F Serotonin Receptor Agonist, LY 344864, LY344864, LY-344864) | A selective, brain penetrant, full agonist for the 5-HT1F receptor (pKi = 8.2). It possesses little affinity for the 56 other serotonergic and non-serotonergic neuronal binding sites examined. When examined for its ability to inhibit forskolin-induced cyclic AMP accumulation in cells stably transfected with human 5-HT1F receptors, LY344864 was shown to be a full agonist producing an effect similar in magnitude to serotonin itself. Suitable for both in vitro and in vivo applications and its effects are often reversed with the 5-HT1B/1D antagonist GR 127935. Group: Biochemicals. Grades: Highly Purified. CAS No. 186544-26-3. Pack Sizes: 10mg. Molecular Formula: C??H??FN?O·HCl. US Biological Life Sciences. | Worldwide |
| LY 354740 ((1S, 2S, 5R, 6S)-2-Aminobicyclo[3. 1. 0]hexane-2, 6-dicarboxy lic Acid, Eglumegad, Eglumetad) | A highly potent agonist selective for group II (mGluR2/3) receptors (EC50 = 5.1 and 24.3nM at mGlu2 and mGlu3 receptors respectively), No effect at other mGlu subtype receptors (mGlu1a, mGlu5a, mGlu4 or mGlu7) at concentration less than 100uM. Biologically viable admitted orally or systematically. Widely used in studies of addiction, epilepsy, schizophrenia, hyperactivity, and sleep. Group: Biochemicals. Grades: Highly Purified. CAS No. 176199-48-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| LY 367385 Hydrochloride ((S)-(+)-alpha-Amino-4-carboxy-2-methylbenzeneacetic Acid) | A potent antagonist selective for mGlu1a receptors (IC50 = 8.8uM and >100uM for mGlu1a and mGlu5a, respectively). Negligible effect on group II and III mGlu receptors. Frequently used in studies assessing the functional roles of mGlu1a in various brain functions and disorders in which neural transmissions via mGlu1a receptors are involved. Group: Biochemicals. Grades: Highly Purified. CAS No. 98419-91-9(FR. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| LY-404,039 ((1R, 4S, 5S, 6S)-4-[[(2S)-2-Amino-4-(methylthio)-1-oxobutyl]amino]-2-thiabicyclo[3. 1. 0]hexane-4, 6-dicarboxylic Acid 2,2-dioxide) | A highly selective and potent agonist for recombinant human mGlu2 and mGlu3 receptors (Ki = 149nM and 92nM, respectively) and for rat neurons mGlu2/3 receptors (Ki = 88nM). Negligible interactions with other mGlu receptors and ionotropic glutamate receptors, glutamate transporter subtypes, monoamine and other receptors. Widely used for investigating neuropsychiatric disorders in animal models and developing potential treatment for human mental disorders, such as schizophrenia. Group: Biochemicals. Grades: Highly Purified. CAS No. 635318-55-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| LY 83583 (LY83583, 6-Anilino-5,8-quinolinequinone) | A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC50=2uM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca2+ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells. Also inhibits neutrophil chemotaxis induced by NO donors. Group: Biochemicals. Grades: Highly Purified. CAS No. 91300-60-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| LYP Inhibitor II, LTV-1 (Lymphoid Tyrosine Phosphatase Inhibitor II, LTV-1, (E) -3- ( (4- ( (4, 6-Dioxo-2-thioxo-1-o-tolyltetra hydropyrimidin-5 (6H) -ylide ne ) methyl ) phenoxy) methyl ) benzoic Acid) | A cell-permeable thiobarbituryl-benzoate compound that acts as a highly potent and reversible inhibitor of lymphoid tyrosine phosphatase (LYP) (IC50=508nM) and thereby enhances TCR signaling in intact cells. Exhibits competitive to mixed mode of inhibition (Ki=384nM). Also shown to inhibit the mutant, disease associated LYP-Trp620 activity. Binds to the phosphate-binding loop and mimicks the phosphotyrosine moiety of substrates. Displays acceptable selectivity over a wide range of protein phosphatases (TCPTP, PTP1B, PEP (mouse LYP), SHP1, CD45 and PTP-PEST: IC50=1.52, 1.59, 7.56, 23.2, 30.1, and 100uM, respectively). Does not exhibit any toxicity at pharmacological doses when tested in primary human cell lines. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Lysolipin I | Antibiotic. Glycopeptide synthesis inhibitor. Antibacterial, antifungal and anticoccidial. Cytotoxic. Group: Biochemicals. Grades: Highly Purified. CAS No. 59113-57-4. Pack Sizes: 500ug, 1mg. US Biological Life Sciences. | Worldwide |
| Lysozyme, Positive Control (LZM, LYZ, Renal Amyloidosis, N-Acetylmuramide Glycanhydrolase, Muramidase) | Lysozyme, Positive Control (LZM, LYZ, Renal Amyloidosis, N-Acetylmuramide Glycanhydrolase, Muramidase). Group: Molecular Biology. Pack Sizes: 15ul. US Biological Life Sciences. | Worldwide |
| Magnesium Phosphate Hydrate | Magnesium Phosphate Hydrate is used in the synthesis of phosphate-calcium coated magnesium alloys for application towards implants. Group: Biochemicals. Grades: Highly Purified. CAS No. 53408-95-0. Pack Sizes: 250mg, 500mg. Molecular Formula: Mg3O8P2. US Biological Life Sciences. | Worldwide |
| Malformin A1 | Peptide antibiotic. Antibcaterial. Plant growth stimulator. Induces root curvature and malformation in plants. Mycotoxin. Prevents interleukin-1 (IL-1) induced endothelial changes by inhibition of protein synthesis. Inhibitor of interleukin-1 beta (IL1 beta) binding to its receptor. Enhancer of cellular fibrinolytic activity. Disrupts the cell cycle at the G2 checkpoint of cancer cells, leading to sensitization of the cancer cells to anti-cancer reagents. Anticancer compound. Cytotoxic against several cancer cell lines. Antimalarial and antitrypanosomal. Inhibitor of BRAF-mutated melanoma cell lines. Group: Biochemicals. Grades: Highly Purified. CAS No. 3022-92-2. Pack Sizes: 250ug, 1mg. Molecular Formula: C??H??N?O?S?. US Biological Life Sciences. | Worldwide |
| MALT1 Inhibitor I, MI-2 (ALB-H03200218, 2-Chloro-N-(4-(5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl)phenyl)acetamide) | A cell-permeable chloromethyl amide that inhibits MALT1 proteolytic activity (IC50 = 5.84uM against MALT1 paracaspase domain dimer-catalyzed Ac-LRSR-AMC hydrolysis) in an irreversible manner via covalent interaction, displaying little or no activity against caspase-3, -8, or -9. Due to irreversible binding and effective intracellular accumulation (HBL-1 intracellular [MI-2]t = 2h = 5uM; Medium [MI-2]t = 0 = 0.2uM), MI-2 is at least 250-times more effective than Z-VRPR-FMK in blocking constitutive NF-kappaB activity and c-Rel nuclear translocation in HBL-1 cultures (equal or better blockage by 200nM MI-2 than by 50uM Z-VRPR-FMK). Shown to selectively inhibit MALT1-dependent ABC-DLBCL proliferation, but not the MALT1-independent growths of ABC- (HLY-1 and U2932) or GCB-DLBCL (OCI-Ly1 and OCI-Ly7) cells, both in cultures in vitro (GI50 in 48h = 200, 400, 400, and 500nM, respectively, against HBL-1, OCI-Ly3, OCI-Ly10, and TMD8) and in mice in vivo (65%,, 61%, and 0% suppression, respective Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
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